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Huaibing He

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Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Mikhail Reibarkh; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Iyassu K Sebhat; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Yusheng Xiong; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Ping Chen; Charles G Caldwell; Wallace T Ashton; Joseph K Wu; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

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All Publications

2012: Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Mikhail Reibarkh; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Bioorganic & medicinal chemistry letters 2012;22(8):2818-22.
2012: Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Iyassu K Sebhat; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Yusheng Xiong; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Bioorganic & medicinal chemistry letters 2012;22(8):2811-7.
2011: Ping Chen; Charles G Caldwell; Wallace T Ashton; Joseph K Wu; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(6):1880-6.
2009: Scott D Edmondson; Anthony Mastracchio; Jason M. Cox; George J Eiermann; Huaibing He; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ranabir Sinha Roy; Ann E Weber
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4097-101.
2008: Scott D Edmondson; Lan Wei; Jinyou Xu; Jackie Shang; Shiyao Xu; Jianmei Pang; Ashok Chaudhary; Dennis C Dean; Huaibing He; Barbara Leiting; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Giovanna Scapin; Joseph K Wu; Maria G Beconi; Nancy A Thornberry; Ann E Weber
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(7):2409-13.
2008: Dooseop Kim; Jennifer E Kowalchick; Linda L Brockunier; Emma R Parmee; George J Eiermann; Michael H Fisher; Huaibing He; Barbara Leiting; Kathryn Lyons; Giovanna Scapin; Sangita B Patel; Aleksandr Petrov; KellyAnn D Pryor; Ranabir Sinha Roy; Joseph K Wu; Xiaoping Zhang; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Journal of medicinal chemistry 2008;51(3):589-602.
2007: Ping Chen; Charles G Caldwell; Robert J Mathvink; Barbara Leiting; Frank Marsilio; Reshma A Patel; Joseph K Wu; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.
Bioorganic & medicinal chemistry letters 2007;17(21):5853-7.
2007: David E Kaelin; Abigail L Smenton; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Nancy A Thornberry; Ann E Weber; Joseph L Duffy
4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Bioorganic & medicinal chemistry letters 2007;17(21):5806-11.
2007: Jennifer E Kowalchick; Barbara Leiting; KellyAnn D Pryor; Frank Marsilio; Joseph K Wu; Huaibing He; Kathryn A Lyons; George J Eiermann; Aleksandr Petrov; Giovanna Scapin; Reshma A Patel; Nancy A Thornberry; Ann E Weber; Dooseop Kim
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(21):5934-9.
2007: Jason M. Cox; Bart Harper; Anthony Mastracchio; Barbara Leiting; Ranabir Sinha Roy; Reshma A Patel; Joseph K Wu; Kathryn A Lyons; Huaibing He; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ann E Weber; Scott D Edmondson
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(16):4579-83.
2007: Dooseop Kim; Jennifer E Kowalchick; Scott D Edmondson; Anthony Mastracchio; Jinyou Xu; George J Eiermann; Barbara Leiting; Joseph K Wu; KellyAnn D Pryor; Reshma A Patel; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).
Bioorganic & medicinal chemistry letters 2007;17(12):3373-7.
2007: Szalkowski Deborah; Giovanna Scapin; Suresh Singh; Dennis Feng; Joseph W Becker; George J Eiermann; Huaibing He; Kathryn Lyons; Sangita Patel; Aleksandr Petrov; Ranabir Sinha Roy; Bei Zhang; Joseph Wu; Xiaoping Zhang; George A Doss; Nancy A Thornberry; Ann E Weber
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
Bioorganic & medicinal chemistry letters 2007;17(12):3384-7.
2007: Joseph L Duffy; Brian A Kirk; Liping Wang; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Nancy A Thornberry; Ann E Weber
4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.
Bioorganic & medicinal chemistry letters 2007;17(10):2879-85.
2007: Gui-Bai Liang; Xiaoxia Qian; Dennis Feng; Szalkowski Deborah; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn Lyons; Aleksandr Petrov; Ranabir Sinha Roy; Bei Zhang; Joseph Wu; Xiaoping Zhang; Nancy A Thornberry; Ann E Weber
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.
Bioorganic & medicinal chemistry letters 2007;17(7):1903-7.
2007: Szalkowski Deborah; Dennis Feng; Xiaoxia Qian; Gui-Bai Liang; Gerard Kieczykowski; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn Lyons; Aleksandr Petrov; Ranabir Sinha Roy; Bei Zhang; Giovanna Scapin; Sangita Patel; Ying-Duo Gao; Suresh Singh; Joseph Wu; Xiaoping Zhang; Nancy A Thornberry; Ann E Weber
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorganic & medicinal chemistry letters 2007;17(1):49-52.
2006: Jinyou Xu; Lan Wei; Robert J Mathvink; Scott D Edmondson; George J Eiermann; Huaibing He; Joseph F Leone; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5373-7.
2006: Scott D Edmondson; Anthony Mastracchio; Robert J Mathvink; Jiafang He; Bart Harper; You-Jung Park; Maria G Beconi; Jerry Di Salvo; George J Eiermann; Huaibing He; Barbara Leiting; Joseph F Leone; Dorothy A Levorse; Kathryn Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Jackie Shang; Ranabir Sinha Roy; Aaron Smith; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ann E Weber
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2006;49(12):3614-27.
2006: Jinyou Xu; Lan Wei; Robert J Mathvink; Scott D Edmondson; Anthony Mastracchio; George J Eiermann; Huaibing He; Joseph F Leone; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Aleksandr Petrov; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(5):1346-9.
2005: George R Lankas; Barbara Leiting; Ranabir Sinha Roy; George J Eiermann; Maria G Beconi; Szalkowski Deborah; Chi-Chung Chan; Scott D Edmondson; William P Feeney; Huaibing He; Dawn E Ippolito; Dooseop Kim; Kathryn A Lyons; Hyun O Ok; Reshma A Patel; Aleksandr N Petrov; Kelly Ann Pryor; Xiaoxia Qian; Leah Reigle; Andrea Woods; Joseph K Wu; Dennis Zaller; Xiaoping Zhang; Lan Zhu; Ann E Weber; Nancy A Thornberry
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Diabetes 2005;54(10):2988-94.
2005: Scott D Edmondson; Anthony Mastracchio; Joseph L Duffy; George J Eiermann; Huaibing He; Ida Ita; Barbara Leiting; Joseph F Leone; Kathryn A Lyons; Amanda M Makarewicz; Reshma A Patel; Aleksandr Petrov; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(12):3048-52.
2005: Jinyou Xu; Lan Wei; Robert J Mathvink; Jiafang He; You-Jung Park; Huaibing He; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(10):2533-6.
2005: Wallace T Ashton; Rosemary M Sisco; Hong Dong; Kathryn A Lyons; Huaibing He; George A Doss; Barbara Leiting; Reshma A Patel; Joseph K Wu; Frank Marsilio; Nancy A Thornberry; Ann E Weber
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Bioorganic & medicinal chemistry letters 2005;15(9):2253-8.
2005: Dooseop Kim; Liping Wang; Maria G Beconi; George J Eiermann; Michael H Fisher; Huaibing He; Gerard J Hickey; Jennifer E Kowalchick; Barbara Leiting; Kathryn Lyons; Frank Marsilio; Margaret E McCann; Reshma A Patel; Aleksandr Petrov; Giovanna Scapin; Sangita B Patel; Ranabir Sinha Roy; Joseph K Wu; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2005;48(1):141-51.
2004: Scott D Edmondson; Anthony Mastracchio; Maria G Beconi; Lawrence F Colwell; Bahanu Habulihaz; Huaibing He; Sanjeev Kumar; Barbara Leiting; Kathryn A Lyons; Ann Mao; Frank Marsilio; Reshma A Patel; Joseph K Wu; Lan Zhu; Nancy A Thornberry; Ann E Weber; Emma R Parmee
Potent and selective proline derived dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(20):5151-5.
2004: Linda L Brockunier; Jiafang He; Lawrence F Colwell; Bahanu Habulihaz; Huaibing He; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Yohannes Teffera; Joseph K Wu; Nancy A Thornberry; Ann E Weber; Emma R Parmee
Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(18):4763-6.
2004: Jinyou Xu; Hyun O Ok; Edward J Gonzalez; Lawrence F Colwell; Bahanu Habulihaz; Huaibing He; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Joseph K Wu; Nancy A Thornberry; Ann E Weber; Emma R Parmee
Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(18):4759-62.
2004: Charles G Caldwell; Ping Chen; Jiafang He; Emma R Parmee; Barbara Leiting; Frank Marsilio; Reshma A Patel; Joseph K Wu; George J Eiermann; Aleksandr Petrov; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(5):1265-8.
2004: Emma R Parmee; Jiafang He; Anthony Mastracchio; Scott D Edmondson; Lawrence F Colwell; George J Eiermann; William P Feeney; Bahanu Habulihaz; Huaibing He; Ruth Kilburn; Barbara Leiting; Kathryn Lyons; Frank Marsilio; Reshma A Patel; Aleksandr Petrov; Jerry Di Salvo; Joseph K Wu; Nancy A Thornberry; Ann E Weber
4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(1):43-6.