Michael Aschner

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Jiang George C-T; Hughes Sam; Stürzenbaum Stephen R; Evje Lars; Syversen Tore; Aschner Michael
Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium.
Zaja-Milatovic Snjezana; Gupta Ramesh C; Aschner Michael; Milatovic Dejan
Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist.
Milatovic Dejan; Zaja-Milatovic Snjezana; Gupta Ramesh C; Yu Yingchun; Aschner Michael
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity.

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All Publications

2009: Jiang George C-T; Hughes Sam; Stürzenbaum Stephen R; Evje Lars; Syversen Tore; Aschner Michael
Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):345-54.
2009: Zaja-Milatovic Snjezana; Gupta Ramesh C; Aschner Michael; Milatovic Dejan
Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist.
Toxicology and applied pharmacology 2009;240(2):124-31.
2009: Milatovic Dejan; Zaja-Milatovic Snjezana; Gupta Ramesh C; Yu Yingchun; Aschner Michael
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity.
Toxicology and applied pharmacology 2009;240(2):219-25.
2009: Benedetto Alexandre; Au Catherine; Aschner Michael
Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease.
Chemical reviews 2009;109(10):4862-84.
2009: Helmcke Kirsten J; Syversen Tore; Miller David M; Aschner Michael
Characterization of the effects of methylmercury on Caenorhabditis elegans.
Toxicology and applied pharmacology 2009;240(2):265-72.
2009: Levin Edward D; Aschner Michael; Heberlein Ulrike; Ruden Douglas; Welsh-Bohmer Kathleen A; Bartlett Selena; Berger Karen; Chen Lang; Corl Ammon B; Eddins Donnie; French Rachael; Hayden Kathleen M; Helmcke Kirsten; Hirsch Helmut V B; Linney Elwood; Lnenicka Greg; Page Grier P; Possidente Debra; Possidente Bernard; Kirshner Annette
Genetic aspects of behavioral neurotoxicology.
Neurotoxicology 2009;30(5):741-53.
2009: Santos D B; Schiar V P P; Paixão M W; Meinerz D F; Nogueira C W; Aschner M; Rocha J B T; Barbosa N B V
Hemolytic and genotoxic evaluation of organochalcogens in human blood cells in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 2009;23(6):1195-204.
2009: Sidoryk-Wegrzynowicz Marta; Lee Eunsook; Albrecht Jan; Aschner Michael
Manganese disrupts astrocyte glutamine transporter expression and function.
Journal of neurochemistry 2009;110(3):822-30.
2009: Stanwood Gregg D; Leitch Duncan B; Savchenko Valentina; Wu Jane; Fitsanakis Vanessa A; Anderson Douglas J; Stankowski Jeannette N; Aschner Michael; McLaughlin BethAnn
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia.
Journal of neurochemistry 2009;110(1):378-89.
2009: Lee Eun-Sook Y; Sidoryk Marta; Jiang Haiyan; Yin Zhaobao; Aschner Michael
Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes.
Journal of neurochemistry 2009;110(2):530-44.
2009: Lee Eun-Sook Y; Yin Zhaobao; Milatovic Dejan; Jiang Haiyan; Aschner Michael
Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):156-67.
2009: Santos D B; Schiar V P P; Ribeiro M C P; Schwab R S; Meinerz D F; Allebrandt J; Rocha J B T; Nogueira C W; Aschner M; Barbosa N B V
Genotoxicity of organoselenium compounds in human leukocytes in vitro.
Mutation research 2009;676(1-2):21-6.
2009: Zhang Na; Fitsanakis Vanessa A; Erikson Keith M; Aschner Michael; Avison Malcolm J; Gore John C
A model for the analysis of competitive relaxation effects of manganese and iron in vivo.
NMR in biomedicine 2009;22(4):391-404.
2009: Kaur Parvinder; Evje Lars; Aschner Michael; Syversen Tore
The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity.
Toxicology in vitro : an international journal published in association with BIBRA 2009;23(3):378-85.
2009: de Freitas Andressa Sausen; Funck Vinícius Rafael; Rotta Mariana dos Santos; Bohrer Denise; Mörschbächer Vanessa; Puntel Robson Luís; Nogueira Cristina Wayne; Farina Marcelo; Aschner Michael; Rocha João Batista Teixeira
Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice.
Brain research bulletin 2009;79(1):77-84.
2009: Roos Daniel H; Puntel Robson L; Santos Matheus M; Souza Diogo O G; Farina Marcelo; Nogueira Cristina W; Aschner Michael; Burger Marilise Escobar; Barbosa Nilda B V; Rocha João B T
Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system.
Toxicology in vitro : an international journal published in association with BIBRA 2009;23(2):302-7.
2009: Martins Roberta de P; Braga Hugo de C; da Silva Aline P; Dalmarco Juliana B; de Bem Andreza F; dos Santos Adair Roberto S; Dafre Alcir L; Pizzolatti Moacir G; Latini Alexandra; Aschner Michael; Farina Marcelo
Synergistic neurotoxicity induced by methylmercury and quercetin in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(3):645-9.
2009: Fitsanakis Vanessa A; Thompson Kimberly N; Deery Sarah E; Milatovic Dejan; Shihabi Zak K; Erikson Keith M; Brown Russell W; Aschner Michael
A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze.
Neurotoxicity research 2009;15(2):167-78.
2008: Yin Zhaobao; Jiang Haiyan; Syversen Tore; Rocha João B T; Farina Marcelo; Aschner Michael
The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter.
Journal of neurochemistry 2008;107(4):1083-90.
2008: Avila Daiana Silva; Gubert Priscila; Fachinetto Roselei; Wagner Caroline; Aschner Michael; Rocha João Batista Teixeira; Soares Félix Alexandre Antunes
Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese.
Neurotoxicology 2008;29(6):1062-8.
2008: Kaur Parvinder; Heggland Ingrid; Aschner Michael; Syversen Tore
Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures.
Neurotoxicology 2008;29(6):978-87.
2008: Leung Maxwell C K; Williams Phillip L; Benedetto Alexandre; Au Catherine; Helmcke Kirsten J; Aschner Michael; Meyer Joel N
Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):5-28.
2008: Marreilha dos Santos A P; Santos Dinamene; Au Catherine; Milatovic Dejan; Aschner Michael; Batoréu M Camila C
Antioxidants prevent the cytotoxicity of manganese in RBE4 cells.
Brain research 2008;1236():200-5.
2008: McCallister Monique M; Maguire Mark; Ramesh Aramandla; Aimin Qiao; Liu Sheng; Khoshbouei Habibeh; Aschner Michael; Ebner Ford F; Hood Darryl B
Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function.
Neurotoxicology 2008;29(5):846-54.
2008: Kaur Parvinder; Schulz Kristina; Heggland Ingrid; Aschner Michael; Syversen Tore
The use of fluorescence for detecting MeHg-induced ROS in cell cultures.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(5):1392-8.
2008: Au Catherine; Benedetto Alexandre; Aschner Michael
Manganese transport in eukaryotes: the role of DMT1.
Neurotoxicology 2008;29(4):569-76.
2008: Zaja-Milatovic Snjezana; Gupta Ramesh C; Aschner Michael; Montine Thomas J; Milatovic Dejan
Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum.
Neurotoxicology 2008;29(4):621-7.
2008: Erikson Keith M; Dorman David C; Lash Lawrence H; Aschner Michael
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
Neurotoxicology 2008;29(3):377-85.
2008: West Adrian K; Hidalgo Juan; Eddins Donnie; Levin Edward D; Aschner Michael
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.
Neurotoxicology 2008;29(3):489-503.
2008: Fitsanakis Vanessa A; Zhang Na; Anderson Joel G; Erikson Keith M; Avison Malcolm J; Gore John C; Aschner Michael
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging.
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):116-24.
2008: Aschner Michael
Re: Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set.
Journal of child neurology 2008;23(4):463; author reply 463-5.
2008: Yin Zhaoobao; Aschner Judy L; dos Santos Ana Paula; Aschner Michael
Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures.
Brain research 2008;1203():1-11.
2008: Gellein Kristin; Flaten Trond Peder; Erikson Keith M; Aschner Michael; Syversen Tore
Leaching of trace elements from biological tissue by formalin fixation.
Biological trace element research 2008;121(3):221-5.
2008: Stringari James; Nunes Adriana K C; Franco Jeferson L; Bohrer Denise; Garcia Solange C; Dafre Alcir L; Milatovic Dejan; Souza Diogo O; Rocha João B T; Aschner Michael; Farina Marcelo
Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain.
Toxicology and applied pharmacology 2008;227(1):147-54.
2008: Soldin Offie P; O'Mara Daniel M; Aschner Michael
Thyroid hormones and methylmercury toxicity.
Biological trace element research 2008;126(1-3):1-12.
2007: Jiang George C-T; Tidwell Kristen; McLaughlin Beth Ann; Cai Jiyang; Gupta Ramesh C; Milatovic Dejan; Nass Richard; Aschner Michael
Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):553-65.
2007: Milatovic Dejan; Yin Zhaobao; Gupta Ramesh C; Sidoryk Marta; Albrecht Jan; Aschner Judy L; Aschner Michael
Manganese induces oxidative impairment in cultured rat astrocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):198-205.
2007: Aschner Michael; Guilarte Tomás R; Schneider Jay S; Zheng Wei
Manganese: recent advances in understanding its transport and neurotoxicity.
Toxicology and applied pharmacology 2007;221(2):131-47.
2007: Erikson Keith M; Dorman David C; Lash Lawrence H; Aschner Michael
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):459-66.
2007: Werdich Andreas A; Baudenbacher Franz; Dzhura Igor; Jeyakumar Loice H; Kannankeril Prince J; Fleischer Sidney; LeGrone Alison; Milatovic Dejan; Aschner Michael; Strauss Arnold W; Anderson Mark E; Exil Vernat J
Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2202-11.
2007: Fitsanakis Vanessa A; Piccola Greg; Marreilha dos Santos Ana Paula; Aschner Judy L; Aschner Michael
Putative proteins involved in manganese transport across the blood-brain barrier.
Human & experimental toxicology 2007;26(4):295-302.
2007: Yin Zhaobao; Milatovic Dejan; Aschner Judy L; Syversen Tore; Rocha Joao B T; Souza Diogo O; Sidoryk Marta; Albrecht Jan; Aschner Michael
Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes.
Brain research 2007;1131(1):1-10.
2007: Erikson Keith M; Thompson Khristy; Aschner Judy; Aschner Michael
Manganese neurotoxicity: a focus on the neonate.
Pharmacology & therapeutics 2007;113(2):369-77.
2007: Garcia Stephanie J; Gellein Kristin; Syversen Tore; Aschner Michael
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):205-14.
2007: Au Catherine; Mutkus Lysette; Dobson Allison; Riffle Judy; Lalli Jennifer; Aschner Michael
Effects of nanoparticles on the adhesion and cell viability on astrocytes.
Biological trace element research 2007;120(1-3):248-56.
2006: Aschner Michael; Syversen Tore; Souza Diogo O; Rocha Joao B T
Metallothioneins: mercury species-specific induction and their potential role in attenuating neurotoxicity.
Experimental biology and medicine (Maywood, N.J.) 2006;231(9):1468-73.
2006: Walker Stephen J; Segal Jeffrey; Aschner Michael
Cultured lymphocytes from autistic children and non-autistic siblings up-regulate heat shock protein RNA in response to thimerosal challenge.
Neurotoxicology 2006;27(5):685-92.
2006: Taylor Michael D; Erikson Keith M; Dobson Allison W; Fitsanakis Vanessa A; Dorman David C; Aschner Michael
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain.
Neurotoxicology 2006;27(5):788-97.
2006: Fitsanakis Vanessa A; Zhang Na; Avison Malcolm J; Gore John C; Aschner Judy L; Aschner Michael
The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity.
Neurotoxicology 2006;27(5):798-806.
2006: Aschner M; Lukey B; Tremblay A
The Manganese Health Research Program (MHRP): status report and future research needs and directions.
Neurotoxicology 2006;27(5):733-6.
2006: Garcia Stephanie J; Gellein Kristin; Syversen Tore; Aschner Michael
A manganese-enhanced diet alters brain metals and transporters in the developing rat.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(2):516-25.
2006: Fitsanakis Vanessa A; Au Catherine; Erikson Keith M; Aschner Michael
The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation.
Neurochemistry international 2006;48(6-7):426-33.
2006: Aschner Michael
The transport of manganese across the blood-brain barrier.
Neurotoxicology 2006;27(3):311-4.
2006: Dobson Allison W; Lack Anna K; Erikson Keith M; Aschner Michael
Depleted uranium is not toxic to rat brain endothelial (RBE4) cells.
Biological trace element research 2006;110(1):61-72.
2006: Jiang George C-T; Aschner Michael
Neurotoxicity of depleted uranium: reasons for increased concern.
Biological trace element research 2006;110(1):1-17.
2006: Mutkus Lysette; Aschner Judy L; Syversen Tore; Shanker Gouri; Sonnewald Ursula; Aschner Michael
Mercuric chloride inhibits the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.
Biological trace element research 2006;109(3):267-80.
2006: Donahue Ashley N; Aschner Michael; Lash Lawrence H; Syversen Tore; Sonntag William E
Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus.
Mechanisms of ageing and development 2006;127(1):57-63.
2006: Fitsanakis Vanessa A; Piccola Greg; Aschner Judy L; Aschner Michael
Characteristics of manganese (Mn) transport in rat brain endothelial (RBE4) cells, an in vitro model of the blood-brain barrier.
Neurotoxicology 2006;27(1):60-70.
2006: Erikson Keith M; Aschner Michael
Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter.
Neurotoxicology 2006;27(1):125-30.
2006: Aschner Michael; Dorman David C
Manganese: pharmacokinetics and molecular mechanisms of brain uptake.
Toxicological reviews 2006;25(3):147-54.
2006: Erikson Keith M; Dorman David C; Fitsanakis Vanessa; Lash Lawrence H; Aschner Michael
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
Biological trace element research 2006;111(1-3):199-215.
2006: Fitsanakis Vanessa A; Erikson Keith M; Garcia Stephanie J; Evje Lars; Syversen Tore; Aschner Michael
Brain accumulation of depleted uranium in rats following 3- or 6-month treatment with implanted depleted uranium pellets.
Biological trace element research 2006;111(1-3):185-97.
2006: Aschner Michael; Fitsanakis Vanessa A; dos Santos Ana Paula Marreilha; Olivi Luisa; Bressler Joseph P
Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood-brain barrier and transport measurements.
Methods in molecular biology (Clifton, N.J.) 2006;341():1-15.
2006: Milatovic Dejan; Gupta Ramesh C; Aschner Michael
Anticholinesterase toxicity and oxidative stress.
TheScientificWorldJournal 2006;6():295-310.
2005: Mutkus Lysette; Aschner Judy L; Syversen Tore; Aschner Michael
Methylmercury alters the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.
Biological trace element research 2005;107(3):231-45.
2005: Mutkus Lysette; Aschner Judy L; Fitsanakis Vanessa; Aschner Michael
The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese.
Biological trace element research 2005;107(3):221-30.
2005: Aschner Michael; West Adrian K
The role of MT in neurological disorders.
Journal of Alzheimer's disease : JAD 2005;8(2):139-45; discussion 209-15.
2005: Aschner Michael; Wu Qi; Friedman Marvin A
Effects of acrylamide on primary neonatal rat astrocyte functions.
Annals of the New York Academy of Sciences 2005;1053():444-54.
2005: Wu Qi; Sidoryk Marta; Mutkus Lysette; Zielinska Magdalena; Albrecht Jan; Aschner Michael
Acrylamide stimulates glutamine uptake in Fischer 344 rat astrocytes by a mechanism involving upregulation of the amino acid transport system N.
Annals of the New York Academy of Sciences 2005;1053():435-43.
2005: Aschner Judy L; Aschner Michael
Nutritional aspects of manganese homeostasis.
Molecular aspects of medicine 2005;26(4-5):353-62.
2005: Fitsanakis Vanessa A; Piccola Greg; Aschner Judy L; Aschner Michael
Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned media.
Journal of neuroscience research 2005;81(2):235-43.
2005: Shanker Gouri; Syversen Tore; Aschner Judy L; Aschner Michael
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.
Brain research. Molecular brain research 2005;137(1-2):11-22.
2005: Aschner Michael; Syversen Tore
Methylmercury: recent advances in the understanding of its neurotoxicity.
Therapeutic drug monitoring 2005;27(3):278-83.
2005: Erikson Keith M; Dorman David C; Lash Lawrence H; Aschner Michael
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
Biological trace element research 2005;104(2):151-63.
2005: Fitsanakis Vanessa A; Aschner Michael
The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity.
Toxicology and applied pharmacology 2005;204(3):343-54.
2005: Aschner Michael; Erikson Keith M; Dorman David C
Manganese dosimetry: species differences and implications for neurotoxicity.
Critical reviews in toxicology 2005;35(1):1-32.
2005: Mutkus Lysette; Aschner Judy L; Syversen Tore; Shanker Gouri; Sonnewald Ursula; Aschner Michael
In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal.
Biological trace element research 2005;105(1-3):71-86.
2004: Erikson Keith M; Dobson Allison W; Dorman David C; Aschner Michael
Manganese exposure and induced oxidative stress in the rat brain.
The Science of the total environment 2004;334-335():409-16.
2004: Aschner Michael; Syversen Tore
Neurotoxicology: principles and considerations of in vitro assessment.
Alternatives to laboratory animals : ATLA 2004;32(4):323-7.
2004: Shanker Gouri; Aschner Judy L; Syversen Tore; Aschner Michael
Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury.
Brain research. Molecular brain research 2004;128(1):48-57.
2004: Erikson Keith M; Dorman David C; Lash Lawrence H; Dobson Allison W; Aschner Michael
Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner.
Biological trace element research 2004;100(1):49-62.
2004: Stredrick Denise L; Stokes Alan H; Worst Travis J; Freeman Willard M; Johnson Elizabeth A; Lash Lawrence H; Aschner Michael; Vrana Kent E
Manganese-induced cytotoxicity in dopamine-producing cells.
Neurotoxicology 2004;25(4):543-53.
2004: Erikson Keith M; Syversen Tore; Steinnes Eiliv; Aschner Michael
Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency.
The Journal of nutritional biochemistry 2004;15(6):335-41.
2004: Dobson Allison W; Erikson Keith M; Aschner Michael
Manganese neurotoxicity.
Annals of the New York Academy of Sciences 2004;1012():115-28.
2004: Shanker Gouri; Hampson Robert E; Aschner Michael
Methylmercury stimulates arachidonic acid release and cytosolic phospholipase A2 expression in primary neuronal cultures.
Neurotoxicology 2004;25(3):399-406.
2003: Shanker Gouri; Syversen Tore; Aschner Michael
Astrocyte-mediated methylmercury neurotoxicity.
Biological trace element research 2003;95(1):1-10.
2003: Erikson Keith M; Aschner Michael
Manganese neurotoxicity and glutamate-GABA interaction.
Neurochemistry international 2003;43(4-5):475-80.
2003: Yang Jian; Aschner Michael
Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport.
Neurotoxicology 2003;24(4-5):741-5.
2003: Vrana Kent E; Freeman Willard M; Aschner Michael
Use of microarray technologies in toxicology research.
Neurotoxicology 2003;24(3):321-32.
2003: Aschner Michael; Cao Cheng-Chen; Wu Qi; Friedman Marvin A
The acute effects of acrylamide on astrocyte functions.
Annals of the New York Academy of Sciences 2003;993():296-304; discussion 345-9.
2003: Shanker Gouri; Aschner Michael
Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants.
Brain research. Molecular brain research 2003;110(1):85-91.
2003: Dobson Allison W; Weber Sarah; Dorman David C; Lash Lawrence K; Erikson Keith M; Aschner Michael
Oxidative stress is induced in the rat brain following repeated inhalation exposure to manganese sulfate.
Biological trace element research 2003;93(1-3):113-26.
2002: Allen Jeffrey W; Shanker Gouri; Tan Kim H; Aschner Michael
The consequences of methylmercury exposure on interactive functions between astrocytes and neurons.
Neurotoxicology 2002;23(6):755-9.
2002: Allen Jeffrey W; Mutkus Lysette A; Aschner Michael
Chronic ethanol produces increased taurine transport and efflux in cultured astrocytes.
Neurotoxicology 2002;23(6):693-700.
2002: Erikson Keith; Aschner Michael
Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes.
Neurotoxicology 2002;23(4-5):595-602.
2002: Aschner Michael; Sonnewald Ursula; Tan Kim H
Astrocyte modulation of neurotoxic injury.
Brain pathology (Zurich, Switzerland) 2002;12(4):475-81.
2002: Shanker Gouri; Mutkus Lysette A; Walker Stephen J; Aschner Michael
Methylmercury enhances arachidonic acid release and cytosolic phospholipase A2 expression in primary cultures of neonatal astrocytes.
Brain research. Molecular brain research 2002;106(1-2):1-11.
2002: Erikson Keith M; Suber Robert L; Aschner Michael
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate.
Neurotoxicology 2002;23(3):281-8.
2002: Weber Sarah; Dorman David C; Lash Lawrence H; Erikson Keith; Vrana Kent E; Aschner Michael
Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints.
Neurotoxicology 2002;23(2):169-75.
2002: Aschner Michael; Shanker Gouri; Erikson Keith; Yang Jian; Mutkus Lysette A
The uptake of manganese in brain endothelial cultures.
Neurotoxicology 2002;23(2):165-8.
2002: Aschner Michael
Open issues from the 15th International Conference on Manganese.
Neurotoxicology 2002;23(2):123-5.
2002: Aschner M; Walker S J
The neuropathogenesis of mercury toxicity.
Molecular psychiatry 2002;7 Suppl 2():S40-1.
2002: Erikson Keith M; Shihabi Zakariya K; Aschner Judy L; Aschner Michael
Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations.
Biological trace element research 2002;87(1-3):143-56.
2001: Aschner M; Seegal R F
Selected presentations and general discussion: session IX summary and research needs.
Neurotoxicology 2001;22(6):849-52.
2001: Shanker G; Aschner M
Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport.
Journal of neuroscience research 2001;66(5):998-1002.
2001: Yang J; Mutkus L A; Sumner D; Stevens J T; Eldridge J C; Strandhoy J W; Aschner M
Transendothelial permeability of chlorpyrifos in RBE4 monolayers is modulated by astrocyte-conditioned medium.
Brain research. Molecular brain research 2001;97(1):43-50.
2001: Aschner M; Mutkus L; Allen J W
Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures.
Neurotoxicology 2001;22(5):601-5.
2001: Shanker G; Allen J W; Mutkus L A; Aschner M
Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons.
Brain research 2001;914(1-2):159-65.
2001: Allen J W; El-Oqayli H; Aschner M; Syversen T; Sonnewald U
Methylmercury has a selective effect on mitochondria in cultured astrocytes in the presence of [U-(13)C]glutamate.
Brain research 2001;908(2):149-54.
2001: Aschner M; Mutkus L A; Allen J W
Amino acid uptake and release in primary astrocyte cultures exposed to ethanol.
Annals of the New York Academy of Sciences 2001;939():23-7.
2001: Shanker G; Allen J W; Mutkus L A; Aschner M
The uptake of cysteine in cultured primary astrocytes and neurons.
Brain research 2001;902(2):156-63.
2001: Allen J W; Mutkus L A; Aschner M
Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.
Brain research 2001;902(1):92-100.
2001: Aschner M; Allen J W; Mutkus L A; Cao C
Ethanol-induced swelling in neonatal rat primary astrocyte cultures.
Brain research 2001;900(2):219-26.
2001: Allen J W; Shanker G; Aschner M
Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons.
Brain research 2001;894(1):131-40.
2001: Allen J W; Mutkus L A; Aschner M
Mercuric chloride, but not methylmercury, inhibits glutamine synthetase activity in primary cultures of cortical astrocytes.
Brain research 2001;891(1-2):148-57.
2000: Aschner M
Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels.
Neurotoxicology 2000;21(6):1101-7.
2000: Aschner M; Allen J W
Astrocytes in methylmercury, ammonia, methionine sulfoximine and alcohol-induced neurotoxicity.
Neurotoxicology 2000;21(4):573-9.
2000: Aschner M; Yao C P; Allen J W; Tan K H
Methylmercury alters glutamate transport in astrocytes.
Neurochemistry international 2000;37(2-3):199-206.
2000: Aschner M
Astrocytic swelling, phospholipase A2, glutathione and glutamate: interactions in methylmercury-induced neurotoxicity.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):843-54.
2000: Aschner M
Manganese: brain transport and emerging research needs.
Environmental health perspectives 2000;108 Suppl 3():429-32.
2000: Stokes A H; Lewis D Y; Lash L H; Jerome W G; Grant K W; Aschner M; Vrana K E
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
Brain research 2000;858(1):1-8.
2000: Aschner M
Interactions between pesticides and glia: an unexplored experimental field.
Neurotoxicology 2000;21(1-2):175-80.
2000: Yao C P; Allen J W; Mutkus L A; Xu S B; Tan K H; Aschner M
Foreign metallothionein-I expression by transient transfection in MT-I and MT-II null astrocytes confers increased protection against acute methylmercury cytotoxicity.
Brain research 2000;855(1):32-8.
1999: Aschner M; Vrana K E; Zheng W
Manganese uptake and distribution in the central nervous system (CNS).
Neurotoxicology 1999;20(2-3):173-80.
1999: Yao C P; Allen J W; Conklin D R; Aschner M
Transfection and overexpression of metallothionein-I in neonatal rat primary astrocyte cultures and in astrocytoma cells increases their resistance to methylmercury-induced cytotoxicity.
Brain research 1999;818(2):414-20.
1999: Yao C P; Allen J W; Aschner M
Metallothioneins attenuate methylmercury-induced neurotoxicity in cultured astrocytes and astrocytoma cells.
Annals of the New York Academy of Sciences 1999;890():223-6.
1999: Aschner M; Allen J W; Kimelberg H K; LoPachin R M; Streit W J
Glial cells in neurotoxicity development.
Annual review of pharmacology and toxicology 1999;39():151-73.
1998: Aschner M; Conklin D R; Yao C P; Allen J W; Tan K H
Induction of astrocyte metallothioneins (MTs) by zinc confers resistance against the acute cytotoxic effects of methylmercury on cell swelling, Na+ uptake, and K+ release.
Brain research 1998;813(2):254-61.
1998: Aschner M; Vitarella D; Allen J W; Conklin D R; Cowan K S
Methylmercury-induced inhibition of regulatory volume decrease in astrocytes: characterization of osmoregulator efflux and its reversal by amiloride.
Brain research 1998;811(1-2):133-42.
1998: Aschner M
Metallothionein (MT) isoforms in the central nervous system (CNS): regional and cell-specific distribution and potential functions as an antioxidant.
Neurotoxicology 1998;19(4-5):653-60.
1998: Aschner M; Vitarella D; Allen J W; Conklin D R; Cowan K S
Methylmercury-induced astrocytic swelling is associated with activation of the Na+/H+ antiporter, and is fully reversed by amiloride.
Brain research 1998;799(2):207-14.
1998: Conklin D R; Tan K H; Aschner M
Dimethyl sulfoxide, but not acidosis-induced metallothionein mRNA expression in neonatal rat primary astrocyte cultures is inhibited by the bioflavonoid, quercetin.
Brain research 1998;794(2):304-8.
1998: Aschner M
Astrocytes as mediators of immune and inflammatory responses in the CNS.
Neurotoxicology 1998;19(2):269-81.
1998: Aschner M; Stark S; Vrana K E; Conklin D R
Acidosis-induced metallothionein (MT) mRNA expression in neonatal rat primary astrocyte cultures.
Neurotoxicology 1998;19(2):227-36.
1998: Aschner M
Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction--a forum position paper.
Neurotoxicology 1998;19(1):7-17; discussion 37-8.
1997: Aschner M; Lorscheider F L; Cowan K S; Conklin D R; Vimy M J; Lash L H
Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0).
Brain research 1997;778(1):222-32.
1997: Aschner M; Conklin D R; Aschner J L
Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity and not ethanol (EtOH) per se.
Brain research 1997;770(1-2):289-93.
1997: Aschner M
Astrocyte metallothioneins (MTs) and their neuroprotective role.
Annals of the New York Academy of Sciences 1997;825():334-47.
1997: Aschner M; Cherian M G; Klaassen C D; Palmiter R D; Erickson J C; Bush A I
Metallothioneins in brain--the role in physiology and pathology.
Toxicology and applied pharmacology 1997;142(2):229-42.
1996: Vitarella D; Conklin D R; Kimelberg H K; Aschner M
Metallothionein induction protects swollen rat primary astrocyte cultures from methylmercury-induced inhibition of regulatory volume decrease.
Brain research 1996;738(2):213-21.
1996: Vitarella D; Kimelberg H K; Aschner M
Inhibition of regulatory volume decrease in swollen rat primary astrocyte cultures by methylmercury is due to increased amiloride-sensitive Na+ uptake.
Brain research 1996;732(1-2):169-78.
1996: Cowan K; Conklin D; Aschner M
Metallothionein induction by bismuth in neonatal rat primary astrocyte cultures.
Brain research 1996;732(1-2):106-12.
1996: Aschner M
The functional significance of brain metallothioneins.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(10):1129-36.
1996: Aschner M
Astrocytes as modulators of mercury-induced neurotoxicity.
Neurotoxicology 1996;17(3-4):663-9.
1996: Vitarella D; Kimelberg H K; Aschner M
Regulatory volume decrease in primary astrocyte cultures: relevance to methylmercury neurotoxicity.
Neurotoxicology 1996;17(1):117-23.
1996: Aschner M; Rising L; Mullaney K J
Differential sensitivity of neonatal rat astrocyte cultures to mercuric chloride (MC) and methylmercury (MeHg): studies on K+ and amino acid transport and metallothionein (MT) induction.
Neurotoxicology 1996;17(1):107-16.
1996: Aschner M
Methylmercury in astrocytes--what possible significance?
Neurotoxicology 1996;17(1):93-106.
1995: Rising L; Vitarella D; Kimelberg H K; Aschner M
Metallothionein induction in neonatal rat primary astrocyte cultures protects against methylmercury cytotoxicity.
Journal of neurochemistry 1995;65(4):1562-8.
1995: Aschner M; Mullaney K J; Wagoner D E; Lash L H; Kimelberg H K
Adenosine modulates methylmercuric chloride (MeHgCl)-induced D-aspartate release from neonatal rat primary astrocyte cultures.
Brain research 1995;689(1):1-8.
1995: Rising L; Vitarella D; Kimelberg H K; Aschner M
Cadmium chloride (CdCl2)-induced metallothionein (MT) expression in neonatal rat primary astrocyte cultures.
Brain research 1995;678(1-2):91-8.
1994: Aschner M; Mullaney K J; Fehm M N; Wagoner D E; Vitarella D
Astrocytes as potential modulators of mercuric chloride neurotoxicity.
Cellular and molecular neurobiology 1994;14(6):637-52.
1994: Aschner M; Mullaney K J; Wagoner D; Lash L H; Kimelberg H K
Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures.
Brain research 1994;664(1-2):133-40.
1994: Vitarella D; DiRisio D J; Kimelberg H K; Aschner M
Potassium and taurine release are highly correlated with regulatory volume decrease in neonatal primary rat astrocyte cultures.
Journal of neurochemistry 1994;63(3):1143-9.
1994: Aschner M; Mullaney K J; Fehm M N; Vitarella D; Wagoner D E; Kimelberg H K
The role of sulfhydryl groups in D-aspartate and rubidium release from neonatal rat primary astrocyte cultures.
Brain research 1994;648(1):16-23.
1994: Mullaney K J; Fehm M N; Vitarella D; Wagoner D E; Aschner M
The role of -SH groups in methylmercuric chloride-induced D-aspartate and rubidium release from rat primary astrocyte cultures.
Brain research 1994;641(1):1-9.
1994: Aschner M; Gannon M
Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms.
Brain research bulletin 1994;33(3):345-9.
1994: Dave V; Mullaney K J; Goderie S; Kimelberg H K; Aschner M
Astrocytes as mediators of methylmercury neurotoxicity: effects on D-aspartate and serotonin uptake.
Developmental neuroscience 1994;16(3-4):222-31.
1993: Mullaney K J; Vitarella D; Albrecht J; Kimelberg H K; Aschner M
Stimulation of D-aspartate efflux by mercuric chloride from rat primary astrocyte cultures.
Brain research. Developmental brain research 1993;75(2):261-8.
1993: Dave V; Vitarella D; Aschner J L; Fletcher P; Kimelberg H K; Aschner M
Lead increases inositol 1,4,5-trisphosphate levels but does not interfere with calcium transients in primary rat astrocytes.
Brain research 1993;618(1):9-18.
1993: Aschner M; LoPachin R M
Astrocytes: targets and mediators of chemical-induced CNS injury.
Journal of toxicology and environmental health 1993;38(3):329-42.
1993: LoPachin R M; Aschner M
Glial-neuronal interactions: relevance to neurotoxic mechanisms.
Toxicology and applied pharmacology 1993;118(2):141-58.
1993: Aschner M; Du Y L; Gannon M; Kimelberg H K
Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures.
Brain research 1993;602(2):181-6.
1992: Aschner M; Gannon M; Kimelberg H K
Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium, L-glutamate and D-aspartate.
Brain research 1992;582(2):181-5.
1992: Aschner M; Gannon M; Kimelberg H K
Manganese uptake and efflux in cultured rat astrocytes.
Journal of neurochemistry 1992;58(2):730-5.
1992: Aschner M; Aschner J L
Cellular and molecular effects of trimethyltin and triethyltin: relevance to organotin neurotoxicity.
Neuroscience and biobehavioral reviews 1992;16(4):427-35.
1991: Aschner M; Eberle N B; Kimelberg H K
Interactions of methylmercury with rat primary astrocyte cultures: methylmercury efflux.
Brain research 1991;554(1-2):10-4.
1991: Aschner M; Chen R; Kimelberg H K
Effects of mercury and lead on rubidium uptake and efflux in cultured rat astrocytes.
Brain research bulletin 1991;26(4):639-42.
1991: Aschner M; Aschner J L
Manganese neurotoxicity: cellular effects and blood-brain barrier transport.
Neuroscience and biobehavioral reviews 1991;15(3):333-40.
1990: Aschner M; Eberle N B; Miller K; Kimelberg H K
Interactions of methylmercury with rat primary astrocyte cultures: inhibition of rubidium and glutamate uptake and induction of swelling.
Brain research 1990;530(2):245-50.
1990: Aschner M; Aschner J L
Manganese transport across the blood-brain barrier: relationship to iron homeostasis.
Brain research bulletin 1990;24(6):857-60.
1990: Aschner M; Eberle N B; Goderie S; Kimelberg H K
Methylmercury uptake in rat primary astrocyte cultures: the role of the neutral amino acid transport system.
Brain research 1990;521(1-2):221-8.
1990: Aschner M; Aschner J L
Mercury neurotoxicity: mechanisms of blood-brain barrier transport.
Neuroscience and biobehavioral reviews 1990;14(2):169-76.
1989: Aschner M
Brain, kidney and liver 203Hg-methyl mercury uptake in the rat: relationship to the neutral amino acid carrier.
Pharmacology & toxicology 1989;65(1):17-20.

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