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Xingxuan He

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Calogera M Simonaro; Hui B Sun; Victor A Deangelis; Efrat Eliyahu; Yi Ge; Mark E Haskins; Xingxuan He; Daniel J Leong; Jeffrey B Mason; Dean W Richardson; Sylvain Sachot; Edward H Schuchman
Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.
Edward H Schuchman; Gary Striker; Helen Vlassara; Yury Borisov; Efrat Eliyahu; Meghan Faillace; Yi Ge; Xingxuan He; James Iatridis; Alon Lai; Calogera M Simonaro
Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses.
Xingxuan He; Edward H Schuchman
Potential role of acid sphingomyelinase in environmental health.

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All Publications

2013: Calogera M Simonaro; Hui B Sun; Victor A Deangelis; Efrat Eliyahu; Yi Ge; Mark E Haskins; Xingxuan He; Daniel J Leong; Jeffrey B Mason; Dean W Richardson; Sylvain Sachot; Edward H Schuchman
Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.
PloS one 2013;8(4):e62715.
2013: Edward H Schuchman; Gary Striker; Helen Vlassara; Yury Borisov; Efrat Eliyahu; Meghan Faillace; Yi Ge; Xingxuan He; James Iatridis; Alon Lai; Calogera M Simonaro
Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses.
PloS one 2013;8(1):e54459.
2012: Xingxuan He; Edward H Schuchman
Potential role of acid sphingomyelinase in environmental health.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2012;37(2):109-25.
2011: Efrat Eliyahu; Xingxuan He; Ruth Shalgi; Nataly Shtraizent; Dafna Chen; Edward H Schuchman
Identification of cystatin SA as a novel inhibitor of acid ceramidase.
The Journal of biological chemistry 2011;286(41):35624-33.
2010: Jonathan P Desnick; Jungmin Kim; Xingxuan He; Melissa P Wasserstein; Calogera M Simonaro; Edward H Schuchman
Identification and characterization of eight novel SMPD1 mutations causing types A and B Niemann-Pick disease.
Molecular medicine (Cambridge, Mass.) 2010;16(7-8):316-21.
2010: Christina Tam; Vincent Idone; Cecilia Devlin; Maria Cecilia Fernandes; Andrew Flannery; Xingxuan He; Edward Schuchman; Ira Tabas; Norma W Andrews
Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair.
The Journal of cell biology 2010;189(6):1027-38.
2010: Efrat Eliyahu; Nataly Shtraizent; Kurt Martinuzzi; Jason Barritt; Xingxuan He; Hong Wei; Sanjeev Chaubal; Alan B Copperman; Edward H Schuchman
Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(4):1229-38.
2010: Xingxuan He; Yu Huang; Bin Li; Cheng-Xin Gong; Edward H Schuchman
Deregulation of sphingolipid metabolism in Alzheimer's disease.
Neurobiology of aging 2010;31(3):398-408.
2010: Calogera M Simonaro; Yi Ge; Efrat Eliyahu; Xingxuan He; Karl Jepsen; Edward H Schuchman
Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):222-7.
2010: Rajwinder Dhami; Xingxuan He; Edward H Schuchman
Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;26(4-5):749-60.
2009: Xingxuan He; Chien-Ling Huang; Edward H Schuchman
Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(10):983-90.
2008: Emyr Lloyd-Evans; Anthony J Morgan; Xingxuan He; David A Smith; Elena Elliot-Smith; Dan J Sillence; Grant C Churchill; Edward H Schuchman; Antony Galione; Frances M Platt
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
Nature medicine 2008;14(11):1247-55.
2008: Iwan Jones; Xingxuan He; Fourogh Katouzian; Peter I Darroch; Edward H Schuchman
Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models.
Molecular genetics and metabolism 2008;95(3):152-62.
2008: Nataly Shtraizent; Efrat Eliyahu; Jae-Ho Park; Xingxuan He; Ruth Shalgi; Edward H Schuchman
Autoproteolytic cleavage and activation of human acid ceramidase.
The Journal of biological chemistry 2008;283(17):11253-9.
2008: Calogera M Simonaro; Marina D'Angelo; Xingxuan He; Efrat Eliyahu; Nataly Shtraizent; Mark E Haskins; Edward H Schuchman
Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases.
The American journal of pathology 2008;172(1):112-22.
2008: Levi G Ledgerwood; Girdhari Lal; Nan Zhang; Alexandre Garin; Steven J Esses; Ginhoux Florent; Miriam Merad; Helene Peche; sergio lira; Yaozhong Ding; Yu Yang; Xingxuan He; Edward H Schuchman; Maria Allende; Jordi C Ochando; Jonathan Bromberg
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Nature immunology 2008;9(1):42-53.
2007: N Matthew Ellinwood; Marie-Anne Colle; Margaret A Weil; Margret L Casal; Charles H Vite; Staci P Wiemelt; Christopher W Hasson; Thomas M O'Malley; Xingxuan He; Ulana Prociuk; Lucie Verot; John R Melniczek; Anne Lannon; Gustavo D Aguirre; Van W Knox; Sydney Evans; marie T vanier; Edward H Schuchman; Steven U Walkley; Mark E Haskins
Bone marrow transplantation for feline mucopolysaccharidosis I.
Molecular genetics and metabolism 2007;91(3):239-50.
2007: Efrat Eliyahu; Jae-Ho Park; Nataly Shtraizent; Xingxuan He; Edward H Schuchman
Acid ceramidase is a novel factor required for early embryo survival.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1403-9.
2005: Peter I Darroch; Arie Dagan; Tami Granot; Xingxuan He; Shimon Gatt; Edward H Schuchman
A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death.
Journal of lipid research 2005;46(11):2315-24.
2005: Xingxuan He; Arie Dagan; Shimon Gatt; Edward H Schuchman
Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase.
Analytical biochemistry 2005;340(1):113-22.
2003: Xingxuan He; Nozomu Okino; Rajwinder Dhami; Arie Dagan; Shimon Gatt; Heike Schulze; Konrad Sandhoff; Edward H Schuchman
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.
The Journal of biological chemistry 2003;278(35):32978-86.
2003: Nozomu Okino; Xingxuan He; Shimon Gatt; Konrad Sandhoff; Makoto Ito; Edward H Schuchman
The reverse activity of human acid ceramidase.
The Journal of biological chemistry 2003;278(32):29948-53.
2003: Xingxuan He; Fei Chen; Arie Dagan; Shimon Gatt; Edward H Schuchman
A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease.
Analytical biochemistry 2003;314(1):116-20.
2002: Avigdor Butler; Xingxuan He; Ronald E Gordon; Hai-Shan Wu; Shimon Gatt; Edward H Schuchman
Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient mice.
The American journal of pathology 2002;161(3):1061-75.
2002: Xingxuan He; Fei Chen; Margaret M McGovern; Edward H Schuchman
A fluorescence-based, high-throughput sphingomyelin assay for the analysis of Niemann-Pick disease and other disorders of sphingomyelin metabolism.
Analytical biochemistry 2002;306(1):115-23.
2002: Chi-Ming Li; Jae-Ho Park; Calogera M Simonaro; Xingxuan He; Ronald E Gordon; Adriana Haimovitz-Friedman; Desiree Ehleiter; François Paris; Katia Manova-Todorova; Stefan Hepbildikler; Zvi Fuks; Konrad Sandhoff; Richard Kolesnick; Edward H Schuchman; Stefan Hepbiloikler
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.
Genomics 2002;79(2):218-24.
2001: Rajwinder Dhami; Xingxuan He; Ronald E Gordon; Edward H Schuchman
Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick disease.
Laboratory investigation; a journal of technical methods and pathology 2001;81(7):987-99.
2001: Xingxuan He; Fei Chen; Shimon Gatt; Edward H Schuchman
An enzymatic assay for quantifying sphingomyelin in tissues and plasma from humans and mice with Niemann-Pick disease.
Analytical biochemistry 2001;293(2):204-11.
2001: E D Kakkis; Edward H Schuchman; Xingxuan He; Qiang Wan; S Kania; Staci P Wiemelt; Christopher W Hasson; Thomas M O'Malley; Margaret A Weil; G A Aguirre; DE Brown; Mark E Haskins
Enzyme replacement therapy in feline mucopolysaccharidosis I.
Molecular genetics and metabolism 2001;72(3):199-208.
2000: SR Miranda; Xingxuan He; Calogera M Simonaro; Shimon Gatt; Arie Dagan; Robert J Desnick; Edward H Schuchman
Infusion of recombinant human acid sphingomyelinase into niemann-pick disease mice leads to visceral, but not neurological, correction of the pathophysiology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):1988-95.
1999: S B Hong; Chi-Ming Li; H J Rhee; Jae-Ho Park; Xingxuan He; Brynn Levy; O J Yoo; Edward H Schuchman
Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein.
Genomics 1999;62(2):232-41.
1999: Chi-Ming Li; Jae-Ho Park; Xingxuan He; Brynn Levy; F Chen; K Arai; DA Adler; Christine M Disteche; J Koch; Konrad Sandhoff; Edward H Schuchman
The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression.
Genomics 1999;62(2):223-31.
1999: Xingxuan He; Chi-Ming Li; Jae-Ho Park; Arie Dagan; Shimon Gatt; Edward H Schuchman
A fluorescence-based high-performance liquid chromatographic assay to determine acid ceramidase activity.
Analytical biochemistry 1999;274(2):264-9.
1999: Xingxuan He; SR Miranda; X Xiong; Arie Dagan; Shimon Gatt; Edward H Schuchman
Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells.
Biochimica et biophysica acta 1999;1432(2):251-64.
1999: Xingxuan He; Chi-Ming Li; Calogera M Simonaro; Qiang Wan; Mark E Haskins; Robert J Desnick; Edward H Schuchman
Identification and characterization of the molecular lesion causing mucopolysaccharidosis type I in cats.
Molecular genetics and metabolism 1999;67(2):106-12.
1998: Chi-Ming Li; S B Hong; G Kopal; Xingxuan He; Thomas Linke; Wu-Shiun Hou; J Koch; Shimon Gatt; Konrad Sandhoff; Edward H Schuchman
Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase.
Genomics 1998;50(2):267-74.