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You Ai He

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TOP 3
Ketan S Gajiwala; You Ai He; Karen Maegley; RoseAnn Ferre; Xiu Yu
Ack1: activation and regulation by allostery.
Ketan S Gajiwala; Joe C Wu; James Christensen; Gayatri D Deshmukh; Wade Diehl; Jonathan P DiNitto; Jessie M English; Michael J Greig; You Ai He; Suzanne L Jacques; Elizabeth A Lunney; Michele McTigue; David Molina; Terri Quenzer; Peter A Wells; Xiu Yu; Yan Zhang; Aihua Zou; Mark R Emmett; Alan G Marshall; Hui-Min Zhang; George D Demetri
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Ram P Gupta; You Ai He; Kennerly S Patrick; James Halpert; Norman H Bell
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.

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All Publications

2013: Ketan S Gajiwala; You Ai He; Karen Maegley; RoseAnn Ferre; Xiu Yu
Ack1: activation and regulation by allostery.
PloS one 2013;8(1):e53994.
2009: Ketan S Gajiwala; Joe C Wu; James Christensen; Gayatri D Deshmukh; Wade Diehl; Jonathan P DiNitto; Jessie M English; Michael J Greig; You Ai He; Suzanne L Jacques; Elizabeth A Lunney; Michele McTigue; David Molina; Terri Quenzer; Peter A Wells; Xiu Yu; Yan Zhang; Aihua Zou; Mark R Emmett; Alan G Marshall; Hui-Min Zhang; George D Demetri
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1542-7.
2005: Ram P Gupta; You Ai He; Kennerly S Patrick; James Halpert; Norman H Bell
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.
The Journal of clinical endocrinology and metabolism 2005;90(2):1210-9.
2004: Emily E Scott; Mark A White; You Ai He; Eric F Johnson; C David Stout; James Halpert
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.
The Journal of biological chemistry 2004;279(26):27294-301.
2004: Chong-Sheng Chen; Jack T Lin; Kendrick A Goss; You Ai He; James Halpert; David J Waxman
Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
Molecular pharmacology 2004;65(5):1278-85.
2004: Yoshitaka Yamaguchi; Kishore K Khan; You Ai He; You Qun He; James Halpert
Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):155-61.
2003: Emily E Scott; You Ai He; Michael R Wester; Mark A White; Christopher C Chin; James Halpert; Eric F Johnson; C David Stout
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13196-201.
2003: You Ai He; Fabienne Roussel; James Halpert
Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling.
Archives of biochemistry and biophysics 2003;409(1):92-101.
2002: Kishore K Khan; You Ai He; You Qun He; James Halpert
Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site.
Chemical research in toxicology 2002;15(6):843-53.
2001: Tammy L Domanski; You Ai He; Kishore K Khan; Fabienne Roussel; Qinmi Wang; James Halpert
Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.
Biochemistry 2001;40(34):10150-60.
2001: R Eiselt; Tammy L Domanski; Arne Zibat; R Mueller; E Presecan-Siedel; Elisabeth Hustert; Uli Zanger; J Brockmoller; H P Klenk; Urs A Meyer; Kishore K Khan; You Ai He; James Halpert; Leszek Wojnowski
Identification and functional characterization of eight CYP3A4 protein variants.
Pharmacogenetics 2001;11(5):447-58.
2000: Tammy L Domanski; You Ai He; GR Harlow; James Halpert
Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
The Journal of pharmacology and experimental therapeutics 2000;293(2):585-91.
1999: S C Waller; You Ai He; GR Harlow; You Qun He; Eugene A. Mash Jr.; James Halpert
2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
Chemical research in toxicology 1999;12(8):690-9.
1997: You Ai He; You Qun He; Grazyna D Szklarz; James Halpert
Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
Biochemistry 1997;36(29):8831-9.
1997: GR Harlow; You Ai He; James Halpert
Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
Biochimica et biophysica acta 1997;1338(2):259-66.
1996: K He; You Ai He; Grazyna D Szklarz; James Halpert; Maria Almira Correia
Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation.
The Journal of biological chemistry 1996;271(42):25864-72.
1996: J Liu; You Ai He; James Halpert
Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
Archives of biochemistry and biophysics 1996;327(1):167-73.
1995: Grazyna D Szklarz; You Ai He; James Halpert
Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1.
Biochemistry 1995;34(44):14312-22.
1995: You Qun He; You Ai He; James Halpert
Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
Chemical research in toxicology 1995;8(4):574-9.
1994: G H John; J A Hasler; You Ai He; James Halpert
Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
Archives of biochemistry and biophysics 1994;314(2):367-75.
1994: J A Hasler; GR Harlow; Grazyna D Szklarz; G H John; K M Kedzie; V L Burnett; You Ai He; L S Kaminsky; James Halpert
Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
Molecular pharmacology 1994;46(2):338-45.
1994: Z Luo; You Ai He; James Halpert
Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
Archives of biochemistry and biophysics 1994;309(1):52-7.
1993: James Halpert; You Ai He
Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
The Journal of biological chemistry 1993;268(6):4453-7.
1992: You Ai He; Celia A Balfour; K M Kedzie; James Halpert
Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1.
Biochemistry 1992;31(38):9220-6.
1991: K M Kedzie; Celia A Balfour; G Y Escobar; S W Grimm; You Ai He; D J Pepperl; John W Regan; JC Stevens; James Halpert
Molecular basis for a functionally unique cytochrome P450IIB1 variant.
The Journal of biological chemistry 1991;266(33):22515-21.