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You Qun He

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Dmitri Davydov; Alexandra E Botchkareva; Santosh Kumar; You Qun He; James Halpert
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
Yoshitaka Yamaguchi; Kishore K Khan; You Ai He; You Qun He; James Halpert
Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis.
Emily E Scott; You Qun He; James Halpert
Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

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2004: Dmitri Davydov; Alexandra E Botchkareva; Santosh Kumar; You Qun He; James Halpert
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
Biochemistry 2004;43(21):6475-85.
2004: Yoshitaka Yamaguchi; Kishore K Khan; You Ai He; You Qun He; James Halpert
Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):155-61.
2002: Emily E Scott; You Qun He; James Halpert
Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.
Chemical research in toxicology 2002;15(11):1407-13.
2002: Kishore K Khan; You Qun He; Maria Almira Correia; James Halpert
Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):985-90.
2002: Kishore K Khan; You Ai He; You Qun He; James Halpert
Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site.
Chemical research in toxicology 2002;15(6):843-53.
2002: Kishore K Khan; You Qun He; Tammy L Domanski; James Halpert
Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation.
Molecular pharmacology 2002;61(3):495-506.
2001: Tammy L Domanski; You Qun He; Emily E Scott; Qinmi Wang; James Halpert
The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.
Archives of biochemistry and biophysics 2001;394(1):21-8.
2001: You Qun He; Fabienne Roussel; James Halpert
Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
Archives of biochemistry and biophysics 2001;389(2):264-70.
2001: Margit Spatzenegger; Qinmi Wang; You Qun He; Michael R Wester; Eric F Johnson; James Halpert
Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles.
Molecular pharmacology 2001;59(3):475-84.
1999: S C Waller; You Ai He; GR Harlow; You Qun He; Eugene A. Mash Jr.; James Halpert
2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
Chemical research in toxicology 1999;12(8):690-9.
1999: D J Fraser; You Qun He; GR Harlow; James Halpert
Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.
Molecular pharmacology 1999;55(2):241-7.
1998: You Qun He; GR Harlow; Grazyna D Szklarz; James Halpert
Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
Archives of biochemistry and biophysics 1998;350(2):333-9.
1997: You Ai He; You Qun He; Grazyna D Szklarz; James Halpert
Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
Biochemistry 1997;36(29):8831-9.
1996: You Qun He; Grazyna D Szklarz; James Halpert
Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
Archives of biochemistry and biophysics 1996;335(1):152-60.
1996: Grazyna D Szklarz; You Qun He; K M Kedzie; James Halpert; V L Burnett
Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
Archives of biochemistry and biophysics 1996;327(2):308-18.
1995: You Qun He; You Ai He; James Halpert
Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
Chemical research in toxicology 1995;8(4):574-9.