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Mark Head

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Mark W Head; Nicholas A Fletcher; Richard S Knight; Jan P M Langeveld; Diane L Ritchie; Helen Yull; James W Ironside
Variably protease-sensitive prionopathy in the U.K.: a retrospective review 1991-2008.
Lynne I McGuire; Christina D Orrú; Alexander H Peden; Jason M Wilham; Robert G Will; Mary Andrews; Nigel E Appleford; Byron Caughey; Mark W Head; Richard S G Knight; Gary Mallinson; Alison J E Green
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease.
Mark W Head; James W Ironside
The contribution of different prion protein types and host polymorphisms to clinicopathological variations in Creutzfeldt-Jakob disease.

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All Publications

2013: Mark W Head; Nicholas A Fletcher; Richard S Knight; Jan P M Langeveld; Diane L Ritchie; Helen Yull; James W Ironside
Variably protease-sensitive prionopathy in the U.K.: a retrospective review 1991-2008.
Brain : a journal of neurology 2013;136(Pt 4):1102-15.
2012: Lynne I McGuire; Christina D Orrú; Alexander H Peden; Jason M Wilham; Robert G Will; Mary Andrews; Nigel E Appleford; Byron Caughey; Mark W Head; Richard S G Knight; Gary Mallinson; Alison J E Green
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease.
Annals of neurology 2012;72(2):278-85.
2012: Mark W Head; James W Ironside
The contribution of different prion protein types and host polymorphisms to clinicopathological variations in Creutzfeldt-Jakob disease.
Reviews in medical virology 2012;22(4):214-29.
2012: Mark W Head; James W Ironside
Review: Creutzfeldt-Jakob disease: prion protein type, disease phenotype and agent strain.
Neuropathology and applied neurobiology 2012;38(4):296-310.
2012: Alexander H Peden; Jason M Wilham; Robert G Will; Nigel E J Appleford; Byron Caughey; Alison J E Green; James W Ironside; Richard S Knight; Gary Mallinson; Lynne Irene McGuire; Christina D Orrú; Mark W Head
Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion.
The Journal of general virology 2012;93(Pt 2):438-49.
2011: K Sherwood; C Smith; R Walker; Mark W Head; James W Ironside; J K Fazakerley
A new index of agonal state for neurological disease.
Neuropathology and applied neurobiology 2011;37(6):672-5.
2011: K R Sherwood; C Smith; R Walker; Mark W Head; James W Ironside; J K Fazakerley
RNA integrity in post mortem human variant Creutzfeldt-Jakob disease (vCJD) and control brain tissue.
Neuropathology and applied neurobiology 2011;37(6):633-42.
2011: Young Pyo Choi; Albrecht Gröner; James W Ironside; Mark W Head
Correlation of polydispersed prion protein and characteristic pathology in the thalamus in variant Creutzfeldt-Jakob disease: implication of small oligomeric species.
Brain pathology (Zurich, Switzerland) 2011;21(3):298-307.
2011: Zuzana Krejciova; Steve Pells; Enrico Cancellotti; Paz Freile; Matthew Bishop; Kay Samuel; G Robin Barclay; James W Ironside; Jean C Manson; Marc L Turner; Paul De Sousa; Mark W Head
Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro.
The Journal of pathology 2011;223(5):635-45.
2011: Young Pyo Choi; Albrecht Gröner; James W Ironside; Mark W Head
Comparison of the level, distribution and form of disease-associated prion protein in variant and sporadic Creutzfeldt-Jakob diseased brain using conformation-dependent immunoassay and Western blot.
The Journal of general virology 2011;92(Pt 3):727-32.
2010: Mark W Head; Suzanne Lowrie; Gurjit Chohan; Richard Knight; David J Scoones; James W Ironside
Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, α synuclein and Aβ pathology.
Acta neuropathologica 2010;120(6):821-3.
2010: Young Pyo Choi; Alexander H Peden; Albrecht Gröner; James W Ironside; Mark W Head
Distinct stability states of disease-associated human prion protein identified by conformation-dependent immunoassay.
Journal of virology 2010;84(22):12030-8.
2010: Alexander H Peden; Linda McCardle; Mark W Head; S Love; H J T Ward; Simon Cousens; D M Keeling; C M Millar; F G H Hill; James W Ironside
Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia.
Haemophilia : the official journal of the World Federation of Hemophilia 2010;16(2):296-304.
2009: Michael Jones; Darren Wight; Rona Barron; Martin Jeffrey; Jean Manson; Christopher Prowse; James W Ironside; Mark W Head
Molecular model of prion transmission to humans.
Emerging infectious diseases 2009;15(12):2013-6.
2009: Mark W Head; R Knight; M Zeidler; Helen Yull; A Barlow; James W Ironside
A case of protease sensitive prionopathy in a patient in the UK.
Neuropathology and applied neurobiology 2009;35(6):628-32.
2009: Diane L Ritchie; Aileen Boyle; Irene McConnell; Mark W Head; James W Ironside; Moira E Bruce
Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice.
The Journal of general virology 2009;90(Pt 12):3075-82.
2009: Mark W Head; Helen Yull; Diane L Ritchie; Matthew Bishop; James W Ironside
Pathological investigation of the first blood donor and recipient pair linked by transfusion-associated variant Creutzfeldt-Jakob disease transmission.
Neuropathology and applied neurobiology 2009;35(4):433-6.
2009: Helen Yull; James W Ironside; Mark W Head
Further characterisation of the prion protein molecular types detectable in the NIBSC Creutzfeldt-Jakob disease brain reference materials.
Biologicals : journal of the International Association of Biological Standardization 2009;37(4):210-5.
2009: Michael Jones; Darren Wight; Victoria McLoughlin; Katherine Norrby; James W Ironside; John G Connolly; Christine F Farquhar; Ian MacGregor; Mark W Head
An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrP) from human brain specimens.
Brain pathology (Zurich, Switzerland) 2009;19(2):293-302.
2009: Michael Jones; Victoria McLoughlin; John G Connolly; Christine F Farquhar; Ian MacGregor; Mark W Head
Production and characterization of a panel of monoclonal antibodies against native human cellular prion protein.
Hybridoma (2005) 2009;28(1):13-20.
2009: Janice B Barr; Michael Watson; Mark W Head; James W Ironside; Nathan Harris; Caroline Hogarth; Janet R Fraser; Rona Barron
Differential protein profiling as a potential multi-marker approach for TSE diagnosis.
BMC infectious diseases 2009;9():188.
2008: Michael Jones; Alexander H Peden; Darren Wight; Chris V Prowse; Ian MacGregor; Jean Manson; Marc Turner; James W Ironside; Mark W Head
Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay.
Neuroreport 2008;19(18):1783-6.
2008: Alexander H Peden; Marc Turner; Mark W Head; Michael Jones; Ian MacGregor; James Ironside
Advances in the development of a screening test for variant Creutzfeldt-Jakob disease.
Expert opinion on medical diagnostics 2008;2(2):207-19.
2008: James W Ironside; Mark W Head
Biology and neuropathology of prion diseases.
Handbook of clinical neurology 2008;89():779-97.
2007: Glenys A Tennent; Mark W Head; Matthew Bishop; Philip N Hawkins; Robert G Will; R Knight; Alexander H Peden; Linda McCardle; James W Ironside; Mark B Pepys
Disease-associated prion protein is not detectable in human systemic amyloid deposits.
The Journal of pathology 2007;213(4):376-83.
2007: M Jones; Alexander H Peden; Chris V Prowse; A Gröner; Jean C Manson; M L Turner; James W Ironside; Ian MacGregor; Mark W Head
In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc.
The Journal of pathology 2007;213(1):21-6.
2007: Alexander H Peden; Diane L Ritchie; Hafsana P Uddin; Andrew F Dean; Kimberley A F Schiller; Mark W Head; James W Ironside
Abnormal prion protein in the pituitary in sporadic and variant Creutzfeldt-Jakob disease.
The Journal of general virology 2007;88(Pt 3):1068-72.
2007: Timothy J Fagge; G Robin Barclay; G Colin Stove; Gordon Stove; Michael J Robinson; Mark W Head; James W Ironside; Marc L Turner
Application of Atomic Dielectric Resonance Spectroscopy for the screening of blood samples from patients with clinical variant and sporadic CJD.
Journal of translational medicine 2007;5():41.
2007: Mark W Head; James W Ironside
vCJD and the gut: implications for endoscopy.
Gut 2007;56(1):9-11.
2006: Paula C Lourenco; Mary Jo Schmerr; Ian MacGregor; Robert G Will; James W Ironside; Mark W Head
Application of an immunocapillary electrophoresis assay to the detection of abnormal prion protein in brain, spleen and blood specimens from patients with variant Creutzfeldt-Jakob disease.
The Journal of general virology 2006;87(Pt 10):3119-24.
2006: CA Heath; Roger A Barker; T F G Esmonde; P Harvey; R Roberts; P Trend; Mark W Head; C Smith; Jeanne E Bell; James W Ironside; Robert G Will; R S G Knight
Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK.
Journal of neurology, neurosurgery, and psychiatry 2006;77(7):880-2.
2006: Matthew Bishop; Patricia Hart; Lorraine Aitchison; Herbert N Baybutt; C Plinston; Val Thomson; Nadia L Tuzi; Mark W Head; James W Ironside; Robert G Will; Jean C Manson
Predicting susceptibility and incubation time of human-to-human transmission of vCJD.
Lancet neurology 2006;5(5):393-8.
2006: Alexander H Peden; Diane L Ritchie; Mark W Head; James W Ironside
Detection and localization of PrPSc in the skeletal muscle of patients with variant, iatrogenic, and sporadic forms of Creutzfeldt-Jakob disease.
The American journal of pathology 2006;168(3):927-35.
2006: Helen Yull; Diane L Ritchie; Jan P M Langeveld; Fred G van Zijderveld; Moira E Bruce; James W Ironside; Mark W Head
Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.
The American journal of pathology 2006;168(1):151-7.
2006: C A Goodall; Mark W Head; Dawn Everington; James W Ironside; R S G Knight; A J E Green
Raised CSF phospho-tau concentrations in variant Creutzfeldt-Jakob disease: diagnostic and pathological implications.
Journal of neurology, neurosurgery, and psychiatry 2006;77(1):89-91.
2005: James W Ironside; Diane L Ritchie; Mark W Head
Phenotypic variability in human prion diseases.
Neuropathology and applied neurobiology 2005;31(6):565-79.
2005: Michael Jones; Mark W Head; John G Connolly; Christine F Farquhar; Valerie S Hornsey; Duncan S Pepper; Ian MacGregor
Purification of normal cellular prion protein from human platelets and the formation of a high molecular weight prion protein complex following platelet activation.
Biochemical and biophysical research communications 2005;335(1):48-56.
2005: Mark W Head; Alexander H Peden; Helen Yull; Diane L Ritchie; Richard E Bonshek; Andrew B Tullo; James W Ironside
Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease.
The British journal of ophthalmology 2005;89(9):1131-3.
2005: Mark W Head; E Kouverianou; L Taylor; Alison Green; Richard Knight
Evaluation of urinary PrPSc as a diagnostic test for sporadic, variant, and familial CJD.
Neurology 2005;64(10):1794-6.
2005: Timothy J Fagge; G Robin Barclay; Ian MacGregor; Mark W Head; James Ironside; Marc Turner
Variation in concentration of prion protein in the peripheral blood of patients with variant and sporadic Creutzfeldt-Jakob disease detected by dissociation enhanced lanthanide fluoroimmunoassay and flow cytometry.
Transfusion 2005;45(4):504-13.
2005: Mark W Head; James W Ironside
Mad cows and monkey business: the end of vCJD?
Lancet 2005;365(9461):730-1.
2004: James W Ironside; Mark W Head
Variant Creutzfeldt-Jakob disease: risk of transmission by blood and blood products.
Haemophilia : the official journal of the World Federation of Hemophilia 2004;10 Suppl 4():64-9.
2004: Alexander H Peden; Mark W Head; Diane L Ritchie; Jeanne E Bell; James W Ironside
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient.
Lancet 2004;364(9433):527-9.
2004: Diane L Ritchie; Mark W Head; James W Ironside
Advances in the detection of prion protein in peripheral tissues of variant Creutzfeldt-Jakob disease patients using paraffin-embedded tissue blotting.
Neuropathology and applied neurobiology 2004;30(4):360-8.
2004: Gianluca Moroncini; Nnennaya Kanu; Laura Solforosi; Gil Abalos; Glenn C Telling; Mark W Head; James Ironside; Jeremy P Brockes; Dennis R Burton; R Anthony Williamson
Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10404-9.
2004: Neil F McLennan; Paul M Brennan; Alisdair McNeill; Ioan Davies; Andrew Fotheringham; Kathleen A Rennison; Diane Ritchie; Francis Brannan; Mark W Head; James W Ironside; Alun Williams; Jeanne E Bell
Prion protein accumulation and neuroprotection in hypoxic brain damage.
The American journal of pathology 2004;165(1):227-35.
2004: Mark W Head; Tristan J R Bunn; Matthew Bishop; Victoria McLoughlin; Suzanne Lowrie; Clive McKimmie; Michelle C Williams; Linda McCardle; Jan MacKenzie; Richard Knight; Robert G Will; James W Ironside
Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: UK cases 1991-2002.
Annals of neurology 2004;55(6):851-9.
2004: David A Hilton; J Sutak; M E F Smith; Mark Penney; Lisa Conyers; Philip Edwards; Linda McCardle; Diane Ritchie; Mark W Head; C A Wiley; James W Ironside
Specificity of lymphoreticular accumulation of prion protein for variant Creutzfeldt-Jakob disease.
Journal of clinical pathology 2004;57(3):300-2.
2004: James W Ironside; Mark W Head
Neuropathology and molecular biology of variant Creutzfeldt-Jakob disease.
Current topics in microbiology and immunology 2004;284():133-59.
2004: Mark W Head; Diane Ritchie; Nadine Smith; Victoria McLoughlin; William Nailon; Sazia Samad; Stephen Masson; Matthew Bishop; Linda McCardle; James W Ironside
Peripheral tissue involvement in sporadic, iatrogenic, and variant Creutzfeldt-Jakob disease: an immunohistochemical, quantitative, and biochemical study.
The American journal of pathology 2004;164(1):143-53.
2003: Mark W Head; Diane Ritchie; Victoria McLoughlin; James W Ironside
Investigation of PrPres in dental tissues in variant CJD.
British dental journal 2003;195(6):339-43; discussion 331.
2003: James W Ironside; Mark W Head
Variant Creutzfeldt-Jakob disease and its transmission by blood.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1479-86.
2003: Eustache Paramithiotis; Marc Pinard; Trebor Lawton; Sylvie LaBoissiere; Valerie L Leathers; Wen-Quan Zou; Lisa A Estey; Julie Lamontagne; Marty T Lehto; Leslie H Kondejewski; Gregory P Francoeur; Maria Papadopoulos; Ashkan Haghighat; Stephen J Spatz; Mark W Head; Robert Will; James Ironside; Katherine O'Rourke; Quentin Tonelli; Harry C Ledebur; Avijit Chakrabartty; Neil R Cashman
A prion protein epitope selective for the pathologically misfolded conformation.
Nature medicine 2003;9(7):893-9.
2003: H J T Ward; Mark W Head; Robert G Will; James W Ironside
Variant Creutzfeldt-Jakob disease.
Clinics in laboratory medicine 2003;23(1):87-108.
2003: Mark W Head; Victoria Northcott; Kathleen A Rennison; Diane Ritchie; Linda McCardle; Tristan J R Bunn; Neil F McLennan; James W Ironside; Andrew B Tullo; Richard E Bonshek
Prion protein accumulation in eyes of patients with sporadic and variant Creutzfeldt-Jakob disease.
Investigative ophthalmology & visual science 2003;44(1):342-6.
2002: John G Connolly; Rothwelle J Tate; Neil F McLennan; Debbie Brown; Glenn C Telling; Jan Fraser; Mark W Head
Properties of the cellular prion protein expressed in Xenopus oocytes.
Neuroreport 2002;13(9):1229-33.
2002: James W Ironside; Mark W Head; Linda McCardle; Richard Knight
Neuropathology of variant Creutzfeldt-Jakob disease.
Acta neurobiologiae experimentalis 2002;62(3):175-82.
2002: James W Ironside; Linda McCardle; A Horsburgh; Ziyi Lim; Mark W Head
Pathological diagnosis of variant Creutzfeldt-Jakob disease.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(1):79-87.
2002: Gabor Geza Kovacs; Mark W Head; Ivan Hegyi; Tristan J R Bunn; Helga Flicker; Johannes A Hainfellner; Linda McCardle; Lajos Laszlo; Christa Jarius; James W Ironside; Herbert Budka
Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes.
Brain pathology (Zurich, Switzerland) 2002;12(1):1-11.
2001: Mark W Head; G Tissingh; Bernard Uitdehaag; F Barkhof; Tristan J R Bunn; James W Ironside; W Kamphorst; Philip scheltens
Sporadic Creutzfeldt-Jakob disease in a young Dutch valine homozygote: atypical molecular phenotype.
Annals of neurology 2001;50(2):258-61.
2001: James W Ironside; D Seilhean; Mark W Head; JEAN-JACQUES HAUW
Investigation of prion diseases.
Current topics in pathology. Ergebnisse der Pathologie 2001;95():179-205.
2000: Gabor Geza Kovacs; Mark W Head; Tristan J R Bunn; Lajos Laszlo; Robert G Will; James W Ironside
Clinicopathological phenotype of codon 129 valine homozygote sporadic Creutzfeldt-Jakob disease.
Neuropathology and applied neurobiology 2000;26(5):463-72.
2000: Mark W Head; James E Goldman
Small heat shock proteins, the cytoskeleton, and inclusion body formation.
Neuropathology and applied neurobiology 2000;26(4):304-12.
2000: James W Ironside; Mark W Head; Jeanne E Bell; Linda McCardle; Robert G Will
Laboratory diagnosis of variant Creutzfeldt-Jakob disease.
Histopathology 2000;37(1):1-9.