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Donna Headlee

Research Profile

Chemicals & Drugs

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Infusions, Intravenous

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Qin C Ryan; Donna Headlee; Milin R Acharya; Alex Sparreboom; Jane Trepel; Joseph Ye; William D Figg; Kyunghwa Hwang; Eun Joo Chung; Anthony J Murgo; Giovanni Melillo; Yusri Elsayed; Manish Monga; Mikhail Kalnitskiy; James Zwiebel; Edward A Sausville
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma.
Alex Sparreboom; Huachen Chen; Milin R Acharya; Adrian M Senderowicz; Richard A Messmann; Takashi Kuwabara; David J Venzon; Anthony J Murgo; Donna Headlee; Edward A Sausville; William D Figg
Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine.
MICHELLE RUDEK-RENAUT; Kenneth S. Bauer; Richard M Lush; Sherman F Stinson; Adrian M Senderowicz; Donna Headlee; Arbuck Susan; Michael C Cox; Anthony J Murgo; Edward A Sausville; William D Figg
Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.

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All Publications

2005: Qin C Ryan; Donna Headlee; Milin R Acharya; Alex Sparreboom; Jane Trepel; Joseph Ye; William D Figg; Kyunghwa Hwang; Eun Joo Chung; Anthony J Murgo; Giovanni Melillo; Yusri Elsayed; Manish Monga; Mikhail Kalnitskiy; James Zwiebel; Edward A Sausville
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3912-22.
2004: Alex Sparreboom; Huachen Chen; Milin R Acharya; Adrian M Senderowicz; Richard A Messmann; Takashi Kuwabara; David J Venzon; Anthony J Murgo; Donna Headlee; Edward A Sausville; William D Figg
Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6840-6.
2003: MICHELLE RUDEK-RENAUT; Kenneth S. Bauer; Richard M Lush; Sherman F Stinson; Adrian M Senderowicz; Donna Headlee; Arbuck Susan; Michael C Cox; Anthony J Murgo; Edward A Sausville; William D Figg
Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
The Annals of pharmacotherapy 2003;37(10):1369-74.
2003: Richard A Messmann; Claudio Dansky Ullmann; Tyler Lahusen; Audrey Kalehua; Jason Wasfy; Giovanni Melillo; Ivan Ding; Donna Headlee; William D Figg; Edward A Sausville; Adrian M Senderowicz
Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):562-70.
2003: Suoping Zhai; Edward A Sausville; Adrian M Senderowicz; Yuichi Ando; Donna Headlee; Richard A Messmann; Arbuck Susan; Anthony J Murgo; Giovanni Melillo; Eiichi Fuse; William D Figg
Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms.
Anti-cancer drugs 2003;14(2):125-35.
2002: Antoinette R Tan; Donna Headlee; Richard A Messmann; Edward A Sausville; Arbuck Susan; Anthony J Murgo; Giovanni Melillo; Suoping Zhai; William D Figg; Sandra M Swain; Adrian M Senderowicz
Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(19):4074-82.
2001: Edward A Sausville; Arbuck Susan; Richard A Messmann; Donna Headlee; Kenneth S. Bauer; Richard M Lush; Anthony J Murgo; William D Figg; Tyler Lahusen; S Jaken; X Jing ; M Roberge; Eiichi Fuse; Takashi Kuwabara; Adrian M Senderowicz
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(8):2319-33.
2000: Richard A Messmann; Ellen S Vitetta; Donna Headlee; Adrian M Senderowicz; William D Figg; John Schindler; D F Michiel; Stephen Creekmore; Seth M Steinberg; David R Kohler; Elaine S Jaffe; Maryalice Stetler-Stevenson; H Chen; Victor Ghetie; Edward A Sausville
A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1302-13.
1999: Raymond C Bergan; Eddie Reed; Charles E Myers; Donna Headlee; Otis W Brawley; H K Cho; William D Figg; AC Tompkins; W Marston Linehan; David R Kohler; Seth M Steinberg; Mikhail V Blagosklonny
A Phase II study of high-dose tamoxifen in patients with hormone-refractory prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2366-73.
1999: Edward A Sausville; Daniel W Zaharevitz; Rick Gussio; Laurent Meijer; M Louarn-Leost; Conrad Kunick; R Schultz; Tyler Lahusen; Donna Headlee; Sherman F Stinson; Arbuck Susan; Adrian M Senderowicz
Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target.
Pharmacology & therapeutics 1999;82(2-3):285-92.
1999: Adrian M Senderowicz; R Reid; Donna Headlee; T Abornathy; J Horti; Richard M Lush; Eddie Reed; William D Figg; Edward A Sausville
A phase II trial of gallium nitrate in patients with androgen-metastatic prostate cancer.
Urologia internationalis 1999;63(2):120-5.
1998: Adrian M Senderowicz; Donna Headlee; Sherman F Stinson; Richard M Lush; N Kalil; L Villalba; K Hill; Seth M Steinberg; William D Figg; AC Tompkins; Arbuck Susan; Edward A Sausville
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(9):2986-99.
1998: Eiichi Fuse; H Tanii; N Kurata; Hiroyuki Kobayashi; Y Shimada; T Tamura; Y Sasaki; Y Tanigawara; R D Lush; Donna Headlee; William D Figg; Arbuck Susan; Adrian M Senderowicz; Edward A Sausville; Shiro Akinaga; Takashi Kuwabara; S Kobayashi
Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.
Cancer research 1998;58(15):3248-53.
1998: Edward A Sausville; R D Lush; Donna Headlee; A C Smith; William D Figg; Arbuck Susan; Adrian M Senderowicz; Eiichi Fuse; H Tanii; Takashi Kuwabara; S Kobayashi
Clinical pharmacology of UCN-01: initial observations and comparison to preclinical models.
Cancer chemotherapy and pharmacology 1998;42 Suppl():S54-9.
1998: Nancy A Dawson; William D Figg; Otis W Brawley; Raymond C Bergan; MR Cooper; Adrian M Senderowicz; Donna Headlee; Seth M Steinberg; M Sutherland; Nicholas Patronas; Edward A Sausville; W Marston Linehan; Eddie Reed; Oliver Sartor
Phase II study of suramin plus aminoglutethimide in two cohorts of patients with androgen-independent prostate cancer: simultaneous antiandrogen withdrawal and prior antiandrogen withdrawal.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):37-44.
1997: Raymond C Bergan; R G Walls; William D Figg; Nancy A Dawson; Donna Headlee; AC Tompkins; Seth M Steinberg; Eddie Reed
Similar clinical outcomes in African-American and non-African-American males treated with suramin for metastatic prostate cancer.
Journal of the National Medical Association 1997;89(9):622-8.
1997: Adrian M Senderowicz; Ellen S Vitetta; Donna Headlee; Victor Ghetie; Jonathan Uhr; William D Figg; Richard M Lush; Maryalice Stetler-Stevenson; G Kershaw; Douglas W Kingma; Elaine S Jaffe; Edward A Sausville
Complete sustained response of a refractory, post-transplantation, large B-cell lymphoma to an anti-CD22 immunotoxin.
Annals of internal medicine 1997;126(11):882-5.
1996: Richard M Lush; William D Figg; James M Pluda; R Bitton; Donna Headlee; David R Kohler; Eddie Reed; Oliver Sartor; MR Cooper
A phase I study of pentosan polysulfate sodium in patients with advanced malignancies.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(9):939-44.
1996: lee stone; Edward A Sausville; Joseph W Fay; Donna Headlee; Robert H Collins; William D Figg; Maryalice Stetler-Stevenson; V Jain; E S Jaffe; D Solomon; Richard M Lush; Adrian M Senderowicz; Victor Ghetie; J Schindler; J W Uhr; Ellen S Vitetta
A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma.
Blood 1996;88(4):1188-97.
1996: Nancy A Dawson; Richard M Lush; Seth M Steinberg; AC Tompkins; Donna Headlee; William D Figg
Suramin-induced neutropenia.
European journal of cancer (Oxford, England : 1990) 1996;32A(9):1534-9.
1996: C J Bowden; William D Figg; Nancy A Dawson; Oliver Sartor; R J Bitton; M S Weinberger; Donna Headlee; Eddie Reed; Charles E Myers; MR Cooper
A phase I/II study of continuous infusion suramin in patients with hormone-refractory prostate cancer: toxicity and response.
Cancer chemotherapy and pharmacology 1996;39(1-2):1-8.
1995: R J Bitton; William D Figg; D J Venzon; Marinos C Dalakas; C Bowden; Donna Headlee; Eddie Reed; Charles E Myers; MR Cooper
Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(9):2223-9.
1995: Nancy A Dawson; MR Cooper; William D Figg; Donna Headlee; A Thibault; Raymond C Bergan; Seth M Steinberg; Edward A Sausville; Charles E Myers; Oliver Sartor
Antitumor activity of suramin in hormone-refractory prostate cancer controlling for hydrocortisone treatment and flutamide withdrawal as potentially confounding variables.
Cancer 1995;76(3):453-62.
1995: Edward A Sausville; Donna Headlee; Maryalice Stetler-Stevenson; Elaine S Jaffe; D Solomon; William D Figg; J Herdt; William Kopp; H Rager; Seth M Steinberg
Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study.
Blood 1995;85(12):3457-65.
1995: A Thibault; D Samid; MR Cooper; William D Figg; AC Tompkins; N Patronas; Donna Headlee; David R Kohler; D J Venzon; Charles E Myers
Phase I study of phenylacetate administered twice daily to patients with cancer.
Cancer 1995;75(12):2932-8.
1995: William D Figg; A Thibault; MR Cooper; R Reid; Donna Headlee; Nancy A Dawson; David R Kohler; Eddie Reed; Oliver Sartor
A phase I study of the somatostatin analogue somatuline in patients with metastatic hormone-refractory prostate cancer.
Cancer 1995;75(8):2159-64.
1995: S C Piscitelli; A Thibault; William D Figg; AC Tompkins; Donna Headlee; R Lieberman; D Samid; Charles E Myers
Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine.
Journal of clinical pharmacology 1995;35(4):368-73.
1994: William D Figg; MR Cooper; A Thibault; Donna Headlee; J Humphrey; Raymond C Bergan; Eddie Reed; Oliver Sartor
Acute renal toxicity associated with suramin in the treatment of prostate cancer.
Cancer 1994;74(5):1612-4.
1994: William D Figg; A Thibault; A O Sartor; D Mays; Donna Headlee; K A Calis; MR Cooper
Hypothyroidism associated with aminoglutethimide in patients with prostate cancer.
Archives of internal medicine 1994;154(9):1023-5.
1994: A Thibault; MR Cooper; William D Figg; D J Venzon; A O Sartor; AC Tompkins; M S Weinberger; Donna Headlee; N A McCall; D Samid
A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.
Cancer research 1994;54(7):1690-4.
1994: Oliver Sartor; M Cooper; M Weinberger; Donna Headlee; A Thibault; AC Tompkins; S Steinberg; William D Figg; W Marston Linehan; Charles E Myers
Surprising activity of flutamide withdrawal, when combined with aminoglutethimide, in treatment of "hormone-refractory" prostate cancer.
Journal of the National Cancer Institute 1994;86(3):222-7.
1993: A Thibault; William D Figg; MR Cooper; S A Prindiville; A O Sartor; Donna Headlee; Charles E Myers
Anaphylactoid reaction with suramin.
Pharmacotherapy 1993;13(6):656-7.
1992: MR Cooper; R Lieberman; R V La Rocca; P R Gernt; M S Weinberger; Donna Headlee; David R Kohler; Barry Goldspiel; C C Peck; Charles E Myers
Adaptive control with feedback strategies for suramin dosing.
Clinical pharmacology and therapeutics 1992;52(1):11-23.