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William Heath

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Gayle M Davey; Brooke Davies; Michelle Gigowski; Scott N Mueller; Catherine van Vliet; Ali Zaid; Francis R Carbone; William R Heath
Identification of a MHC I-restricted epitope of DsRed in C57BL/6 mice.
Scott N Mueller; Francis R Carbone; Thomas Gebhardt; William R Heath
Memory T cell subsets, migration patterns, and tissue residence.
Thomas Gebhardt; William R Heath; Scott N Mueller; Francis R Carbone
Peripheral tissue surveillance and residency by memory T cells.

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2013: Gayle M Davey; Brooke Davies; Michelle Gigowski; Scott N Mueller; Catherine van Vliet; Ali Zaid; Francis R Carbone; William R Heath
Identification of a MHC I-restricted epitope of DsRed in C57BL/6 mice.
Molecular immunology 2013;53(4):450-2.
2013: Scott N Mueller; Francis R Carbone; Thomas Gebhardt; William R Heath
Memory T cell subsets, migration patterns, and tissue residence.
Annual review of immunology 2013;31():137-61.
2013: Thomas Gebhardt; William R Heath; Scott N Mueller; Francis R Carbone
Peripheral tissue surveillance and residency by memory T cells.
Trends in immunology 2013;34(1):27-32.
2012: William R Heath; Scott N Mueller
Hair follicles: gatekeepers to the epidermis.
Nature immunology 2012;13(8):715-7.
2012: Laura K Mackay; Scott N Mueller; Angus T Stock; Francis R Carbone; William R Heath; Claerwen M Jones; Stephen J Kent; Joel Z Ma; Thomas Gebhardt
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):7037-42.
2012: liv eidsmo; William R Heath; Angus T Stock; Sammy Bedoui; Francis R Carbone
Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.
The Journal of pathology 2012;226(5):806-13.
2012: Laura K Mackay; Scott N Mueller; Catherine J van Vliet; Linda Wakim; Oliver Bannard; Douglas T Fearon; William R Heath; Claerwen M Jones; Francis R Carbone
Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(5):2173-8.
2012: Andreas Kupz; Leif E Sander; Kirsty R Short; Richard A Strugnell; Jürg Tschopp; Jason C Waithman; Paul G Whitney; Odilia L C Wijburg; Hanwei Cao; Weisan Chen; Roy Curtiss; Dimitri A Diavatopoulos; Daniel Fernandez-Ruiz; Thomas Gebhardt; Greta Guarda; William R Heath; Sammy Bedoui
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.
Nature immunology 2012;13(2):162-9.
2012: Irina Caminschi; William R Heath; Mireille Lahoud; Kenneth M Murphy; Jose A Villadangos; David Vremec; eta ahmet; Ken Shortman
Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice.
Molecular immunology 2012;50(1-2):9-17.
2011: Lei Shong Lau; Anthony T Papenfuss; Andrew G Brooks; Francis R Carbone; Brendan S Crabb; Gayle M Davey; Tania F de Koning-Ward; Daniel Fernandez Ruiz; William R Heath
Blood-stage Plasmodium berghei infection generates a potent, specific CD8+ T-cell response despite residence largely in cells lacking MHC I processing machinery.
The Journal of infectious diseases 2011;204(12):1989-96.
2011: Sammy Bedoui; William R Heath
A local role for CD103+ dendritic cells in atherosclerosis.
Immunity 2011;35(5):665-7.
2011: Thomas Gebhardt; William R Heath; Laura K Mackay; Andrew G Brooks; Francis R Carbone; Paul G Whitney; Ali Zaid; Scott N Mueller
Different patterns of peripheral migration by memory CD4+ and CD8+ T cells.
Nature 2011;477(7363):216-9.
2011: FX Hubert; Sarah A Kinkel; Adrian Liston; Scott N Mueller; Belinda Phipson; Anna I Proietto; Hamish Scott; Gordon K Smyth; Li Wu; Ping Z F Cannon; Francis R Carbone; Gayle M Davey; Simon Forehan; Christopher C Goodnow; William R Heath
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.
Blood 2011;118(9):2462-72.
2011: Mireille Lahoud; Chin-Nien Lee; Andrew M Lew; Scott N Mueller; Belinda Phipson; Wei Shi; Ken Shortman; Gordon K Smyth; David Vremec; Soo San Wan; Gayle M Davey; William R Heath; Yu Kato; Susie Kitsoulis; eta ahmet; Irina Caminschi
Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):842-50.
2011: Ashraful Haque; Shannon E Best; Klara Unosson; Fiona H Amante; Fabian de Labastida; Nicholas Anstey; Gunasegaran Karupiah; Mark J Smyth; William R Heath; Christian R Engwerda
Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6148-56.
2011: Angus T Stock; Claerwen M Jones; William R Heath; Francis R Carbone
Rapid recruitment and activation of CD8+ T cells after herpes simplex virus type 1 skin infection.
Immunology and cell biology 2011;89(1):143-8.
2010: Francis R Carbone; William R Heath
Cross-priming: its beginnings.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1353-4.
2010: Rachel J Lundie; Louise J Young; Gayle M Davey; Jose A Villadangos; Francis R Carbone; William R Heath; Brendan S Crabb
Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells.
European journal of immunology 2010;40(6):1674-81.
2010: Elodie Segura; Eugene Kapp; Nishma Gupta; June Wong; Justin Lim; Hong Ji; William R Heath; Richard Simpson; Jose A Villadangos
Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis.
Molecular immunology 2010;47(9):1765-73.
2010: Ken Shortman; William R Heath
The CD8+ dendritic cell subset.
Immunological reviews 2010;234(1):18-31.
2010: Gayle M Davey; Magdalena Wojtasiak; Anna I Proietto; Francis R Carbone; William R Heath; Sammy Bedoui
Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2243-6.
2009: William R Heath; Francis R Carbone
Dendritic cell subsets in primary and secondary T cell responses at body surfaces.
Nature immunology 2009;10(12):1237-44.
2009: Mireille Lahoud; Anna I Proietto; eta ahmet; Susie Kitsoulis; liv eidsmo; Li Wu; Priyanka Sathe; Suzanne Pietersz; Hsuen-Wen Chang; Ian D Walker; Eugene Maraskovsky; Hal Braley; Andrew M Lew; Mark D Wright; William R Heath; Ken Shortman; Irina Caminschi
The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7587-94.
2009: Ian K Campbell; Sarah A Kinkel; Sarah F Drake; Annemarie van Nieuwenhuijze; FX Hubert; David M Tarlinton; William R Heath; Hamish Scott; Ian P Wicks
Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis.
Arthritis and rheumatism 2009;60(6):1683-93.
2009: Ian A Parish; Sudha Rao; Gordon K Smyth; Torsten Juelich; Gareth S Denyer; Gayle M Davey; Andreas Strasser; William R Heath
The molecular signature of CD8+ T cells undergoing deletional tolerance.
Blood 2009;113(19):4575-85.
2009: Sammy Bedoui; Paul G Whitney; Jason Waithman; liv eidsmo; Linda Wakim; Irina Caminschi; Rhys S Allan; Magdalena Wojtasiak; Ken Shortman; Francis R Carbone; Andrew G Brooks; William R Heath
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.
Nature immunology 2009;10(5):488-95.
2009: Thomas Gebhardt; Linda M Wakim; liv eidsmo; Patrick Reading; William R Heath; Francis R Carbone
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus.
Nature immunology 2009;10(5):524-30.
2009: Catherine Q Nie; Nicholas J Bernard; M Ursula Norman; Fiona H Amante; Rachel J Lundie; Brendan S Crabb; William R Heath; Christian R Engwerda; Michael J Hickey; Louis Schofield; Diana Hansen
IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection.
PLoS pathogens 2009;5(4):e1000369.
2009: Sammy Bedoui; Sandro Prato; Justine D Mintern; Thomas Gebhardt; Yifan Zhan; Andrew M Lew; William R Heath; Jose A Villadangos; Elodie Segura
Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4200-7.
2009: Ian A Parish; Jason Waithman; Gayle M Davey; Gabrielle Belz; Justine D Mintern; Christian Kurts; Robyn M Sutherland; Francis R Carbone; William R Heath
Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3901-6.
2009: liv eidsmo; Rhys Allan; Irina Caminschi; Nico van Rooijen; William R Heath; Francis R Carbone
Differential migration of epidermal and dermal dendritic cells during skin infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3165-72.
2009: Sammy Bedoui; Gayle M Davey; Andrew M Lew; William R Heath
Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process.
Immunology and cell biology 2009;87(3):255-9.
2009: Susan Johnson; Yifan Zhan; Robyn M Sutherland; Adele M Mount; Sammy Bedoui; Jamie L Brady; Emma M Carrington; Lorena E Brown; Gabrielle Belz; William R Heath; Andrew M Lew
Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells.
Immunity 2009;30(2):218-27.
2008: Linda M Wakim; Thomas Gebhardt; William R Heath; Francis R Carbone
Cutting edge: local recall responses by memory T cells newly recruited to peripheral nonlymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5837-41.
2008: Louise J Young; Nicholas S Wilson; Petra Schnorrer; Anna I Proietto; Toine ten Broeke; Yohei Matsuki; Adele M Mount; Gabrielle Belz; Meredith O'Keeffe; Mari Ohmura-Hoshino; Satoshi Ishido; Willem Stoorvogel; William R Heath; Ken Shortman; Jose A Villadangos
Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.
Nature immunology 2008;9(11):1244-52.
2008: Irina Caminschi; Anna I Proietto; eta ahmet; Susie Kitsoulis; Joo Shin Teh; Jennifer C Y Lo; alexandra rizzitelli; Li Wu; David Vremec; Serani L H van Dommelen; Ian K Campbell; Eugene Maraskovsky; Hal Braley; Gayle M Davey; Patricia Mottram; Nicholas van de Velde; Kent Jensen; Andrew M Lew; Mark D Wright; William R Heath; Ken Shortman; Mireille Lahoud
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.
Blood 2008;112(8):3264-73.
2008: Rachel J Lundie; Tania F de Koning-Ward; Gayle M Davey; Catherine Q Nie; Diana Hansen; Lei Shong Lau; Justine D Mintern; Gabrielle Belz; Louis Schofield; Francis R Carbone; Jose A Villadangos; Brendan S Crabb; William R Heath
Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14509-14.
2008: Jason Waithman; Thomas Gebhardt; Gayle M Davey; William R Heath; Francis R Carbone
Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5789-93.
2008: FX Hubert; Sarah A Kinkel; Kylie E Webster; Ping Cannon; Pauline E Crewther; Anna I Proeitto; Li Wu; William R Heath; Hamish Scott
A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3824-32.
2008: Ming Lee Lin; Yifan Zhan; Anna I Proietto; Sandro Prato; Li Wu; William R Heath; Jose A Villadangos; Andrew M Lew
Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3029-34.
2008: Nicholas S Wilson; Louise J Young; Fiona Kupresanin; Shalin Naik; David Vremec; William R Heath; Shizuo Akira; Ken Shortman; Jeff Boyle; Eugene Maraskovsky; Gabrielle Belz; Jose A Villadangos
Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.
Immunology and cell biology 2008;86(2):200-5.
2008: Linda M Wakim; Jason Waithman; Nico van Rooijen; William R Heath; Francis R Carbone
Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
Science (New York, N.Y.) 2008;319(5860):198-202.
2008: Adele M Mount; Christopher M Smith; Fiona Kupresanin; Kristina Stoermer; William R Heath; Gabrielle Belz
Multiple dendritic cell populations activate CD4+ T cells after viral stimulation.
PloS one 2008;3(2):e1691.
2007: Jason D Price; Kim R Simpfendorfer; Radhakrishnam R Mantena; James Holden; William R Heath; Nico van Rooijen; Richard A Strugnell; Odilia L C Wijburg
Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium.
Infection and immunity 2007;75(12):5753-62.
2007: Louise J Young; Nicholas S Wilson; Petra Schnorrer; Adele M Mount; Rachel J Lundie; Nicole L La Gruta; Brendan S Crabb; Gabrielle Belz; William R Heath; Jose A Villadangos
Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17753-8.
2007: Irina Caminschi; Fatma Ahmet; Klaus Heger; Jason Brady; Stephen L Nutt; David Vremec; Suzanne Pietersz; Mireille Lahoud; Louis Schofield; Diana Hansen; Meredith O'Keeffe; Mark J Smyth; Sammy Bedoui; Gayle M Davey; Jose A Villadangos; William R Heath; Ken Shortman
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells.
The Journal of experimental medicine 2007;204(11):2579-90.
2007: Philip D Hodgkin; William R Heath; Alan G Baxter
The clonal selection theory: 50 years since the revolution.
Nature immunology 2007;8(10):1019-26.
2007: Jason Waithman; Rhys S Allan; Hiroshi Kosaka; Hiroaki Azukizawa; Ken Shortman; Manfred B Lutz; William R Heath; Francis R Carbone; Gabrielle Belz
Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4535-41.
2007: Gabrielle Belz; Sammy Bedoui; Fiona Kupresanin; Francis R Carbone; William R Heath
Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells.
Nature immunology 2007;8(10):1060-6.
2007: Angus T Stock; Scott N Mueller; Lauren Kleinert; William R Heath; Francis R Carbone; Claerwen M Jones
Optimization of TCR transgenic T cells for in vivo tracking of immune responses.
Immunology and cell biology 2007;85(5):394-6.
2007: Daniel Barr; Gabrielle Belz; Patrick Reading; Magdalena Wojtasiak; Paul G Whitney; William R Heath; Francis R Carbone; Andrew G Brooks
A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection.
European journal of immunology 2007;37(5):1334-42.
2007: Jose A Villadangos; William R Heath; Francis R Carbone
Outside looking in: the inner workings of the cross-presentation pathway within dendritic cells.
Trends in immunology 2007;28(2):45-7.
2006: Angus T Stock; Claerwen M Jones; William R Heath; Francis R Carbone
CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant.
Immunology and cell biology 2006;84(6):543-50.
2006: Angus T Stock; Claerwen M Jones; William R Heath; Francis R Carbone
Cutting edge: central memory T cells do not show accelerated proliferation or tissue infiltration in response to localized herpes simplex virus-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1411-5.
2006: Petra Schnorrer; Georg M N Behrens; Nicholas S Wilson; Joanne L Pooley; Christopher M Smith; Dima El-Sukkari; Gayle Davey; Fiona Kupresanin; Ming Li; Eugene Maraskovsky; Gabrielle Belz; Francis R Carbone; Ken Shortman; William R Heath; Jose A Villadangos
The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10729-34.
2006: Rhys S Allan; Jason Waithman; Sammy Bedoui; Claerwen M Jones; Jose A Villadangos; Yifan Zhan; Andrew M Lew; Ken Shortman; William R Heath; Francis R Carbone
Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming.
Immunity 2006;25(1):153-62.
2006: Scott N Mueller; Claerwen M Jones; Angus T Stock; Mark Suter; William R Heath; Francis R Carbone
CD4+ T cells can protect APC from CTL-mediated elimination.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7379-84.
2006: Nicholas S Wilson; Georg M N Behrens; Rachel J Lundie; Christopher M Smith; Jason Waithman; Louise Young; Simon P Forehan; Adele M Mount; Raymond J Steptoe; Ken Shortman; Tania F de Koning-Ward; Gabrielle Belz; Francis R Carbone; Brendan S Crabb; William R Heath; Jose A Villadangos
Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity.
Nature immunology 2006;7(2):165-72.
2006: Gabrielle Belz; Nicholas S Wilson; Christopher M Smith; Adele M Mount; Francis R Carbone; William R Heath
Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin.
European journal of immunology 2006;36(2):327-35.
2006: Gayle M Davey; William R Heath; Robyn Starr
SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
Tissue antigens 2006;67(1):1-9.
2005: Allison L van Lint; Lauren Kleinert; Sally R M Clarke; Angus T Stock; William R Heath; Francis R Carbone
Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory ganglia.
Journal of virology 2005;79(23):14843-51.
2005: Gayle M Davey; Robyn Starr; Ann L Cornish; J Theodore Burghardt; Warren S Alexander; Francis R Carbone; Charles D Surh; William R Heath
SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential.
The Journal of experimental medicine 2005;202(8):1099-108.
2004: Francis R Carbone; Gabrielle Belz; William R Heath
Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity.
Trends in immunology 2004;25(12):655-8.
2004: Christopher M Smith; Nicholas S Wilson; Jason Waithman; Jose A Villadangos; Francis R Carbone; William R Heath; Gabrielle Belz
Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity.
Nature immunology 2004;5(11):1143-8.
2004: Angus T Stock; Scott N Mueller; Allison L van Lint; William R Heath; Francis R Carbone
Cutting edge: prolonged antigen presentation after herpes simplex virus-1 skin infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2241-4.
2004: Gabrielle Belz; Christopher M Smith; Lauren Kleinert; Patrick Reading; Andrew Brooks; Ken Shortman; Francis R Carbone; William R Heath
Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8670-5.
2004: William R Heath; Gabrielle Belz; Georg M N Behrens; Christopher M Smith; Simon P Forehan; Ian A Parish; Gayle M Davey; Nicholas S Wilson; Francis R Carbone; Jose A Villadangos
Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens.
Immunological reviews 2004;199():9-26.
2004: Andreas Villunger; Vanessa S Marsden; Yifan Zhan; Miriam Erlacher; Andrew M Lew; Philippe Bouillet; Stuart P Berzins; Dale I Godfrey; William R Heath; Andreas Strasser
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7052-7.
2004: Georg M N Behrens; Ming Li; Gayle M Davey; Janette Allison; Richard A Flavell; Francis R Carbone; William R Heath
Helper requirements for generation of effector CTL to islet beta cell antigens.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5420-6.
2004: Gabrielle Belz; Christopher M Smith; Daniel Eichner; Ken Shortman; Gunasegaran Karupiah; Francis R Carbone; William R Heath
Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):1996-2000.
2004: Georg M N Behrens; Ming Li; Christopher M Smith; Gabrielle Belz; Justine D Mintern; Francis R Carbone; William R Heath
Helper T cells, dendritic cells and CTL Immunity.
Immunology and cell biology 2004;82(1):84-90.
2004: Allison L van Lint; Margaret Ayers; Andrew G Brooks; Richard M Coles; William R Heath; Francis R Carbone
Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):392-7.
2003: Rhys S Allan; Chris M Smith; Gabrielle Belz; Allison L van Lint; Linda M Wakim; William R Heath; Francis R Carbone
Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells.
Science (New York, N.Y.) 2003;301(5641):1925-8.
2003: Nicholas S Wilson; Dima El-Sukkari; Gabrielle Belz; Christopher M Smith; Raymond J Steptoe; William R Heath; Ken Shortman; Jose A Villadangos
Most lymphoid organ dendritic cell types are phenotypically and functionally immature.
Blood 2003;102(6):2187-94.
2003: Francis R Carbone; William R Heath
The role of dendritic cell subsets in immunity to viruses.
Current opinion in immunology 2003;15(4):416-20.
2003: Hiroaki Azukizawa; Hiroshi Kosaka; Shigetoshi Sano; William R Heath; Ichiro Takahashi; Xing-Hua Gao; Yasuyuki Sumikawa; Masaru Okabe; Kunihiko Yoshikawa; Satoshi Itami
Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes.
European journal of immunology 2003;33(7):1879-88.
2003: Richard M Coles; Claerwen M Jones; Andrew G Brooks; paul cameron; William R Heath; Francis R Carbone
Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes.
European journal of immunology 2003;33(6):1557-67.
2003: Christopher M Smith; Gabrielle Belz; Nicholas S Wilson; Jose A Villadangos; Ken Shortman; Francis R Carbone; William R Heath
Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4437-40.
2003: Yifan Zhan; Jared F Purton; Dale I Godfrey; Timothy J Cole; William R Heath; Andrew M Lew
Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1197-202.
2003: Scott N Mueller; Claerwen M Jones; Weisan Chen; Yoshihiro Kawaoka; Maria R Castrucci; William R Heath; Francis R Carbone
The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8+ T cells.
Journal of virology 2003;77(4):2445-51.
2003: Ann L Cornish; Gayle M Davey; Donald Metcalf; Jared F Purton; Jason E Corbin; Christopher J Greenhalgh; Rima Darwiche; Li Wu; Nicos A Nicola; Dale I Godfrey; William R Heath; Douglas J Hilton; Warren S Alexander; Robyn Starr
Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):878-86.
2002: Gabrielle Belz; Georg M N Behrens; Chris M Smith; Jacques F A P Miller; Claerwen Jones; Kristina Lejon; C Garrison Fathman; Scott N Mueller; Ken Shortman; Francis R Carbone; William R Heath
The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
The Journal of experimental medicine 2002;196(8):1099-104.
2002: Gayle M Davey; Christian Kurts; Jacques F A P Miller; Philippe Bouillet; Andreas Strasser; Andrew G Brooks; Francis R Carbone; William R Heath
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim.
The Journal of experimental medicine 2002;196(7):947-55.
2002: Gabrielle Belz; David Vremec; Maria Febbraio; Lynn M Corcoran; Ken Shortman; Francis R Carbone; William R Heath
CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6066-70.
2002: Scott N Mueller; William R Heath; Julie D McLain; Francis R Carbone; Claerwen M Jones
Characterization of two TCR transgenic mouse lines specific for herpes simplex virus.
Immunology and cell biology 2002;80(2):156-63.
2002: Justine D Mintern; Robyn M Sutherland; Andrew M Lew; Ken Shortman; Francis R Carbone; William R Heath
Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice.
European journal of immunology 2002;32(4):1044-51.
2002: Justine D Mintern; Gabrielle Belz; Steve Gerondakis; Francis R Carbone; William R Heath
The cross-priming APC requires a Rel-dependent signal to induce CTL.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3283-7.
2002: Scott N Mueller; Claerwen M Jones; Chris M Smith; William R Heath; Francis R Carbone
Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus.
The Journal of experimental medicine 2002;195(5):651-6.
2002: Justine D Mintern; Gayle M Davey; Gabrielle Belz; Francis R Carbone; William R Heath
Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):977-80.
2002: Richard M Coles; Scott N Mueller; William R Heath; Francis R Carbone; Andrew G Brooks
Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):834-8.
2002: Gabrielle Belz; Francis R Carbone; William R Heath
Cross-presentation of antigens by dendritic cells.
Critical reviews in immunology 2002;22(5-6):439-48.
2002: Arno Hänninen; Nathan R Martinez; Gayle M Davey; William R Heath; Leonard C Harrison
Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity.
The Journal of clinical investigation 2002;109(2):261-7.
2001: William R Heath; Francis R Carbone
Cross-presentation in viral immunity and self-tolerance.
Nature reviews. Immunology 2001;1(2):126-34.
2001: Ichiro Takahashi; Hiroshi Kosaka; Kenji Oritani; William R Heath; Jun Ishikawa; Y Okajima; Minetaro Ogawa; Shoko Kawamoto; M Yamada; Hiroaki Azukizawa; Satoshi Itami; Kunihiko Yoshikawa; Yoshiaki Tomiyama; Yuji Matsuzawa
A new IFN-like cytokine, limitin, modulates the immune response without influencing thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3156-63.
2001: M Li; Gayle M Davey; Robyn M Sutherland; Christian Kurts; Andrew M Lew; C Hirst; Francis R Carbone; William R Heath
Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6099-103.
2001: Joanne L Pooley; William R Heath; Ken Shortman
Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5327-30.
2000: S R Clarke; MJ Barnden; Christian Kurts; Francis R Carbone; Jacques F A P Miller; William R Heath
Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.
Immunology and cell biology 2000;78(2):110-7.
2000: E Blanas; Gayle M Davey; Francis R Carbone; William R Heath
A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2890-6.
2000: Claerwen M Jones; SC Cose; Richard M Coles; A C Winterhalter; Andrew G Brooks; William R Heath; Francis R Carbone
Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection.
Journal of virology 2000;74(5):2414-9.
2000: Claerwen M Jones; SC Cose; JM McNally; Stephen R Jennings; William R Heath; Francis R Carbone
Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus.
The Journal of general virology 2000;81(Pt 2):407-14.
1999: Justine D Mintern; Ming Li; Gayle M Davey; E Blanas; Christian Kurts; Francis R Carbone; William R Heath
The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo.
Immunology and cell biology 1999;77(6):539-43.
1999: Christian Kurts; Robyn M Sutherland; G Davey; M Li; Andrew M Lew; E Blanas; Francis R Carbone; Jacques F A P Miller; William R Heath
CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12703-7.
1999: M F Krummel; William R Heath; J Allison
Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):2999-3006.
1999: ME Wallace; Rachael Keating; William R Heath; Francis R Carbone
The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant.
Journal of virology 1999;73(9):7619-26.
1999: C Koniaras; Francis R Carbone; William R Heath; Andrew M Lew
Inhibition of naïve class I-restricted T cells by altered peptide ligands.
Immunology and cell biology 1999;77(4):318-23.
1999: William R Heath; C Kurts; Irina Caminschi; Francis R Carbone; J F Miller
CD30 prevents T-cell responses to non-lymphoid tissues.
Immunological reviews 1999;169():23-9.
1999: E Blanas; William R Heath
Oral administration of antigen can lead to the onset of autoimmune disease.
International reviews of immunology 1999;18(3):217-28.
1998: SR Bennett; Francis R Carbone; T Toy; Jacques F A P Miller; William R Heath
B cells directly tolerize CD8(+) T cells.
The Journal of experimental medicine 1998;188(11):1977-83.
1998: J F Miller; Christian Kurts; J Allison; H Kosaka; Francis R Carbone; William R Heath
Induction of peripheral CD8+ T-cell tolerance by cross-presentation of self antigens.
Immunological reviews 1998;165():267-77.
1998: Christian Kurts; William R Heath; H Kosaka; Jacques F A P Miller; Francis R Carbone
The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1).
The Journal of experimental medicine 1998;188(2):415-20.
1998: Christian Kurts; Jacques F A P Miller; R M Subramaniam; Francis R Carbone; William R Heath
Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction.
The Journal of experimental medicine 1998;188(2):409-14.
1998: SR Bennett; Francis R Carbone; F Karamalis; R A Flavell; Jacques F A P Miller; William R Heath
Help for cytotoxic-T-cell responses is mediated by CD40 signalling.
Nature 1998;393(6684):478-80.
1998: William R Heath; Christian Kurts; Jacques F A P Miller; Francis R Carbone
Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens.
The Journal of experimental medicine 1998;187(10):1549-53.
1998: C Koniaras; William R Heath; Andrew M Lew
T cell unresponsiveness in vitro can be due to activation in vivo.
International immunology 1998;10(3):365-9.
1998: J Allison; LA Stephens; Thomas W H Kay; Christian Kurts; William R Heath; J F Miller; M F Krummel
The threshold for autoimmune T cell killing is influenced by B7-1.
European journal of immunology 1998;28(3):949-60.
1998: MJ Barnden; J Allison; William R Heath; Francis R Carbone
Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements.
Immunology and cell biology 1998;76(1):34-40.
1997: Christian Kurts; Francis R Carbone; MJ Barnden; E Blanas; J Allison; William R Heath; Jacques F A P Miller
CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity.
The Journal of experimental medicine 1997;186(12):2057-62.
1997: C Koniaras; SR Bennett; Francis R Carbone; William R Heath; Andrew M Lew
Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ.
International immunology 1997;9(10):1601-5.
1997: SC Cose; Claerwen M Jones; ME Wallace; William R Heath; Francis R Carbone
Antigen-specific CD8+ T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection.
European journal of immunology 1997;27(9):2310-6.
1997: C Kurts; H Kosaka; Francis R Carbone; Jacques F A P Miller; William R Heath
Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells.
The Journal of experimental medicine 1997;186(2):239-45.
1997: SR Bennett; Francis R Carbone; F Karamalis; Jacques F A P Miller; William R Heath
Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.
The Journal of experimental medicine 1997;186(1):65-70.
1997: MJ Barnden; William R Heath; Francis R Carbone
Down-modulation of CD8 beta-chain in response to an altered peptide ligand enables developing thymocytes to escape negative selection.
Cellular immunology 1997;175(2):111-9.
1997: J F Miller; William R Heath; J Allison; Grant Morahan; M Hoffmann; Christian Kurts; H Kosaka
T cell tolerance and autoimmunity.
Ciba Foundation symposium 1997;204():159-68; discussion 168-71.
1996: E Blanas; Francis R Carbone; J Allison; Jacques F A P Miller; William R Heath
Induction of autoimmune diabetes by oral administration of autoantigen.
Science (New York, N.Y.) 1996;274(5293):1707-9.
1996: V Kronin; Ken Winkel; G Süss; A Kelso; William R Heath; J Kirberg; Harald von Boehmer; Ken Shortman
A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3819-27.
1996: Christian Kurts; William R Heath; Francis R Carbone; J Allison; Jacques F A P Miller; H Kosaka
Constitutive class I-restricted exogenous presentation of self antigens in vivo.
The Journal of experimental medicine 1996;184(3):923-30.
1995: M W Hoffmann; William R Heath; D Ruschmeyer; Jacques F A P Miller
Deletion of high-avidity T cells by thymic epithelium.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9851-5.
1995: William R Heath; F Karamalis; J Donoghue; Jacques F A P Miller
Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2339-49.
1995: P Bertolino; William R Heath; C L Hardy; Grant Morahan; Jacques F A P Miller
Peripheral deletion of autoreactive CD8+ T cells in transgenic mice expressing H-2Kb in the liver.
European journal of immunology 1995;25(7):1932-42.
1995: William R Heath; Francis R Carbone; P Bertolino; J Kelly; SC Cose; J F Miller
Expression of two T cell receptor alpha chains on the surface of normal murine T cells.
European journal of immunology 1995;25(6):1617-23.
1995: K Lundberg; William R Heath; F Köntgen; Francis R Carbone; Ken Shortman
Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.
The Journal of experimental medicine 1995;181(5):1643-51.
1995: Jonathan Sprent; M Hurd; M Schaefer; William R Heath
Split tolerance in spleen chimeras.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(3):1198-206.
1994: MJ Barnden; William R Heath; S Rodda; Francis R Carbone
Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion.
European journal of immunology 1994;24(10):2452-6.
1994: Jonathan Sprent; Charles D Surh; D Agus; M Hurd; S Sutton; William R Heath
Profound atrophy of the bone marrow reflecting major histocompatibility complex class II-restricted destruction of stem cells by CD4+ cells.
The Journal of experimental medicine 1994;180(1):307-17.
1994: Kristin A Hogquist; Stephen C Jameson; William R Heath; J L Howard; Michael J Bevan; Francis R Carbone
T cell receptor antagonist peptides induce positive selection.
Cell 1994;76(1):17-27.
1993: William R Heath; L Kjer-Nielsen; M W Hoffmann
Avidity for antigen can influence the helper dependence of CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):5993-6001.
1993: Robyn M Slattery; Jacques F A P Miller; William R Heath; Brett Charlton
Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10808-10.
1993: William R Heath; Jacques F A P Miller
Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.
The Journal of experimental medicine 1993;178(5):1807-11.
1993: Jacques F A P Miller; William R Heath
Self-ignorance in the peripheral T-cell pool.
Immunological reviews 1993;133():131-50.
1993: M W Hoffmann; William R Heath; J Allison; Jacques F A P Miller
Medullary thymic epithelium induces tolerance to allogeneic major histocompatibility complex class I antigens.
Transplantation proceedings 1993;25(1 Pt 1):289-90.
1993: William R Heath; J Allison; Jacques F A P Miller
CD8+ T cell tolerance and autoimmunity to extra-thymic antigens.
Autoimmunity 1993;15(4):293-8.
1992: William R Heath; J Allison; M W Hoffmann; G Schönrich; Günter J Hämmerling; Bernd Arnold; Jacques F A P Miller
Autoimmune diabetes as a consequence of locally produced interleukin-2.
Nature 1992;359(6395):547-9.
1992: J Allison; William R Heath; Jacques F A P Miller
Does interleukin-2 abrogate peripheral immunologic self-tolerance in vivo?
Seminars in immunology 1992;4(3):181-5.
1992: Jacques F A P Miller; William R Heath
Post-thymic T-cell tolerance or indifference: that is the question.
Research in immunology 1992;143(3):313-5.
1991: Stephen C Jameson; P B Nakajima; J L Brooks; William R Heath; O Kanagawa; Nicholas R J Gascoigne
The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3185-93.
1991: William R Heath; K P Kane; matthew mescher; L A Sherman
Alloreactive T cells discriminate among a diverse set of endogenous peptides.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5101-5.
1991: William R Heath; L A Sherman
Cell-type-specific recognition of allogeneic cells by alloreactive cytotoxic T cells: a consequence of peptide-dependent allorecognition.
European journal of immunology 1991;21(1):153-9.
1990: William R Heath; M E Hurd; R Murray; Jeffrey Frelinger; L A Sherman
Analysis of novel residues of class I involved in recognition by alloreactive T cells.
Immunogenetics 1990;32(2):138-41.
1989: William R Heath; M E Hurd; F R Carbone; L A Sherman
Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes.
Nature 1989;341(6244):749-52.
1989: M J Irwin; William R Heath; L A Sherman
Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response.
The Journal of experimental medicine 1989;170(4):1091-101.
1989: A Vitiello; William R Heath; L A Sherman
Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1512-7.
1989: William R Heath; A Vitiello; L A Sherman
Mapping of epitopes recognized by alloreactive cytotoxic T lymphocytes using inhibition by MHC peptides.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1441-6.