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Robert Hebbel

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Apurva V Shirodkar; Rosanne St Bernard; Maneesh Sud; Matthew Shu-Ching Yan; William C Aird; Anna Gavryushova; Robert P Hebbel; Britta J Knight; Anna Kop; Hon-Sum Jeffrey Man; Peter Oettgen; Philip A Marsden
A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing.
Karl A Nath; Gregory M Vercellotti; John D Belcher; Anthony J Croatt; Gianrico Farrugia; Joseph P Grande; Robert P Hebbel; Zvonimir S Katusic
Age sensitizes the kidney to heme protein-induced acute kidney injury.
Javier Martin-Ramirez; Maartje van den Biggelaar; Robert P Hebbel; Menno Hofman; Jan Voorberg
Establishment of outgrowth endothelial cells from peripheral blood.

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2013: Apurva V Shirodkar; Rosanne St Bernard; Maneesh Sud; Matthew Shu-Ching Yan; William C Aird; Anna Gavryushova; Robert P Hebbel; Britta J Knight; Anna Kop; Hon-Sum Jeffrey Man; Peter Oettgen; Philip A Marsden
A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing.
Blood 2013;121(17):3531-40.
2013: Karl A Nath; Gregory M Vercellotti; John D Belcher; Anthony J Croatt; Gianrico Farrugia; Joseph P Grande; Robert P Hebbel; Zvonimir S Katusic
Age sensitizes the kidney to heme protein-induced acute kidney injury.
American journal of physiology. Renal physiology 2013;304(3):F317-25.
2012: Javier Martin-Ramirez; Maartje van den Biggelaar; Robert P Hebbel; Menno Hofman; Jan Voorberg
Establishment of outgrowth endothelial cells from peripheral blood.
Nature protocols 2012;7(9):1709-15.
2012: Daniel A. Mulrooney; James D Neaton; Robert P Hebbel; Aaron S Kelly; Chung K K Lee; Kirsten K Ness; Bruce A Peterson; Anna Solovey; Joseph P Neglia
Pilot study of vascular health in survivors of Hodgkin lymphoma.
Pediatric blood & cancer 2012;59(2):285-9.
2012: Benjamin M Manning; Robert P Hebbel; Kalpna Gupta; Christy L Haynes
Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells.
ACS chemical biology 2012;7(3):543-51.
2012: David M Cain; Robert P Hebbel; Donald A Simone; Derek Vang; Kalpna Gupta
Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness.
British journal of haematology 2012;156(4):535-44.
2012: Marc L Weber; John T Crosson; Pankaj Gupta; Robert P Hebbel; Derek Vang; Paulo E Velho; Kalpna Gupta
Morphine promotes renal pathology in sickle mice.
International journal of nephrology and renovascular disease 2012;5():109-18.
2011: Lu Kang; Zvonimir S Katusic; Andre Terzic; Gregory M Vercellotti; Satsuki Yamada; Anthony J Croatt; Joseph P Grande; Robert P Hebbel; Melissa C Hernandez; Julio P Juncos; Karl A Nath
Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula.
American journal of physiology. Renal physiology 2011;301(4):F845-51.
2011: Katherine A Ahmann; Robert P Hebbel; Sandra L Johnson; Robert T Tranquillo
Shear stress responses of adult blood outgrowth endothelial cells seeded on bioartificial tissue.
Tissue engineering. Part A 2011;17(19-20):2511-21.
2011: Felicity N E Gavins; Janice Russell; Elena L Senchenkova; Lidiana De Almeida Paula; Amílcar S Damazo; Charles T Esmon; Daniel Kirchhofer; Robert P Hebbel; D Neil Granger
Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.
Blood 2011;117(15):4125-33.
2011: Robert P Hebbel
Reconstructing sickle cell disease: a data-based analysis of the "hyperhemolysis paradigm" for pulmonary hypertension from the perspective of evidence-based medicine.
American journal of hematology 2011;86(2):123-54.
2011: Ramiro Juncos; Luis Juncos; Robert P Hebbel; Gregory M Vercellotti; Zvonimir S Katusic; Karl A Nath
Selective enhancement of contractions to α1-adrenergic receptor activation in the aorta of mice with sickle cell disease.
Journal of cardiovascular pharmacology 2011;57(2):263-6.
2010: V Bodempudi; John R Ohlfest; K Terai; E A Zamora; R I Vogel; Kalpna Gupta; Robert P Hebbel; Arkadiusz Z Dudek
Blood outgrowth endothelial cell-based systemic delivery of antiangiogenic gene therapy for solid tumors.
Cancer gene therapy 2010;17(12):855-63.
2010: Aaron S Kelly; Robert P Hebbel; Anna Solovey; Sarah Jane Schwarzenberg; Andrea M Metzig; Antoinette Moran; Alan R Sinaiko; David R Jacobs; Julia Steinberger
Circulating activated endothelial cells in pediatric obesity.
The Journal of pediatrics 2010;157(4):547-51.
2010: Masako Ueda; Ivan Alferiev; Stacey B Simons; Robert P Hebbel; Robert J Levy; Stanley J Stachelek
CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane.
Biomaterials 2010;31(25):6394-9.
2010: H Franklin Bunn; David G Nathan; George J Dover; Robert P Hebbel; Orah S Platt; Wendell F Rosse; Russell E Ware
Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
Blood 2010;116(5):687-92.
2010: Arif Somani; Marie E Steiner; Robert P Hebbel
The dynamic regulation of microcirculatory conduit function: features relevant to transfusion medicine.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2010;43(1):61-8.
2010: Divyanshoo R Kohli; Yunfang Li; Sergey G Khasabov; Pankaj Gupta; Lois J Kehl; Marna E Ericson; Julia Nguyen; Vinita Gupta; Robert P Hebbel; Donald A Simone; Kalpna Gupta
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
Blood 2010;116(3):456-65.
2010: Rahn Kollander; Anna Solovey; Liming C Milbauer; Fuad Abdulla; Robert J Kelm; Robert P Hebbel
Nuclear factor-kappa B (NFkappaB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease.
Translational research : the journal of laboratory and clinical medicine 2010;155(4):170-7.
2010: Julio P Juncos; Joseph P Grande; Anthony J Croatt; Robert P Hebbel; Gregory M Vercellotti; Zvonimir S Katusic; Karl A Nath
Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease.
American journal of physiology. Renal physiology 2010;298(4):F892-9.
2010: Robert P Hebbel; Gregory M Vercellotti; Betty S Pace; Anna Solovey; Rahn Kollander; Chine F Abanonu; Julia Nguyen; Julie V Vineyard; John D Belcher; Fuad Abdulla; Shadé Osifuye; John W Eaton; Robert J Kelm; Arne Slungaard
The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.
Blood 2010;115(12):2483-90.
2010: Anna Solovey; Rahn Kollander; Liming Chang Milbauer; Fuad Abdulla; Yingie Chen; Robert J Kelm; Robert P Hebbel
Endothelial nitric oxide synthase and nitric oxide regulate endothelial tissue factor expression in vivo in the sickle transgenic mouse.
American journal of hematology 2010;85(1):41-5.
2010: Judy Enenstein; Liming Milbauer; Evidio Domingo; Alexandra Wells; Mark Roney; Jim Kiley; Peng Wei; Robert P Hebbel
Proinflammatory phenotype with imbalance of KLF2 and RelA: risk of childhood stroke with sickle cell anemia.
American journal of hematology 2010;85(1):18-23.
2009: Robert P Hebbel; Greg Vercellotti; Karl A Nath
A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsis.
Cardiovascular & hematological disorders drug targets 2009;9(4):271-92.
2009: Sandra J Hasstedt; Irene D Bezemer; Peter W Callas; Carla Y Vossen; Winifred Trotman; Robert P Hebbel; C Demers; Frits R Rosendaal; Edwin G Bovill
Cell adhesion molecule 1: a novel risk factor for venous thrombosis.
Blood 2009;114(14):3084-91.
2009: Joan D Beckman; John D Belcher; Julie V Vineyard; Chunsheng Chen; Julia Nguyen; Michael Nwaneri; M Gerard O'Sullivan; Evin Gulbahce; Robert P Hebbel; Gregory M Vercellotti
Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease.
American journal of physiology. Heart and circulatory physiology 2009;297(4):H1243-53.
2009: Robert P Hebbel
The systems biology-based argument for taking a bold step in chemoprophylaxis of sickle vasculopathy.
American journal of hematology 2009;84(9):543-5.
2009: Gregory Kato ; Robert P Hebbel; Martin H Steinberg; Mark T Gladwin
Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions.
American journal of hematology 2009;84(9):618-25.
2009: Huan Wang; Weiyu Zhang; Rong Tang; Robert P Hebbel; M Anna Kowalska; Chunxiang Zhang; Jamey D Marth; Minoru Fukuda; Chuhong Zhu; Yuqing Huo
Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1053-9.
2009: Maartje van den Biggelaar; Eveline A M Bouwens; Neeltje Kootstra; Robert P Hebbel; Jan Voorberg; Koen Mertens
Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells.
Haematologica 2009;94(5):670-8.
2009: Liming C Milbauer; Judy A Enenstein; Mark Roney; Anna Solovey; Vidya Bodempudi; Timothy C Nichols; Robert P Hebbel
Blood outgrowth endothelial cell migration and trapping in vivo: a window into gene therapy.
Translational research : the journal of laboratory and clinical medicine 2009;153(4):179-89.
2009: Huan Wang; Rong Tang; Weiyu Zhang; Karine Amirikian; Zhen Geng; Jianguo Geng; Robert P Hebbel; Lijun Xia; Jamey D Marth; Minoru Fukuda; Shigeki Katoh; Yuqing Huo
Core2 1-6-N-glucosaminyltransferase-I is crucial for the formation of atherosclerotic lesions in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(2):180-7.
2008: Marc L Weber; Mariya Farooqui; Julia Nguyen; Michael Ansonoff; John E Pintar; Robert P Hebbel; Kalpna Gupta
Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors.
American journal of physiology. Renal physiology 2008;294(6):F1388-97.
2008: Liming Chang Milbauer; Peng Wei; Judy Enenstein; Aixiang Jiang; Cheryl A Hillery; J Paul Scott; Stephen C Nelson; Vidya Bodempudi; James N Topper; Ruey-Bing Yang; Betsy Hirsch; Wei Pan; Robert P Hebbel
Genetic endothelial systems biology of sickle stroke risk.
Blood 2008;111(7):3872-9.
2008: Robert P Hebbel
Adhesion of sickle red cells to endothelium: myths and future directions.
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2008;15(1-2):14-8.
2008: Pawel Zwolak; Arkadiusz Z Dudek; Vidya D Bodempudi; Julia Nguyen; Robert P Hebbel; Nathan J Gallus; Marna E Ericson; Michael J Goblirsch; Denis R Clohisy
Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases.
International journal of cancer. Journal international du cancer 2008;122(3):681-8.
2007: Hideto Matsui; Masaru Shibata; Brian Brown; Andrea Labelle; Carol Hegadorn; Chandler Andrews; Robert P Hebbel; Jacques Galipeau; Christine Hough; David Lillicrap
Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors.
Stem cells (Dayton, Ohio) 2007;25(10):2660-9.
2007: Arkadiusz Z Dudek; V Bodempudi; B W Welsh; P Jasinski; R J Griffin; Liming C Milbauer; Robert P Hebbel
Systemic inhibition of tumour angiogenesis by endothelial cell-based gene therapy.
British journal of cancer 2007;97(4):513-22.
2007: Aixiang Jiang; Wei Pan; Liming C Milbauer; Yu Shyr; Robert P Hebbel
A practical question based on cross-platform microarray data normalization: are BOEC more like large vessel or microvascular endothelial cells or neither of them?
Journal of bioinformatics and computational biology 2007;5(4):875-93.
2007: Arif Somani; Julia Nguyen; Liming C Milbauer; Anna Solovey; Suchitra Sajja; Robert P Hebbel
The establishment of murine blood outgrowth endothelial cells and observations relevant to gene therapy.
Translational research : the journal of laboratory and clinical medicine 2007;150(1):30-9.
2007: Mary M Lunzer; Ajay Yekkirala; Robert P Hebbel; Philip S Portoghese
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):6061-5.
2007: Betsy T Kren; Wenxan Yin; Nigel S Key; Robert P Hebbel; Clifford J Steer
Blood outgrowth endothelial cells as a vehicle for transgene expression of hepatocyte-secreted proteins via Sleeping Beauty.
Endothelium : journal of endothelial cell research 2007;14(2):97-104.
2006: Amitava Das; Martin E Fernandez Zapico; Sheng Cao; Janet Yao; Stefano Fiorucci; Robert P Hebbel; Raul Urrutia; Vijay H Shah
Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.
The Journal of biological chemistry 2006;281(51):39105-13.
2006: Trisha Dasgupta; Robert P Hebbel; Dhananjay K Kaul
Protective effect of arginine on oxidative stress in transgenic sickle mouse models.
Free radical biology & medicine 2006;41(12):1771-80.
2006: Wei Pan; Xiaotong Shen; Aixiang Jiang; Robert P Hebbel
Semi-supervised learning via penalized mixture model with application to microarray sample classification.
Bioinformatics (Oxford, England) 2006;22(19):2388-95.
2006: Dhananjay K Kaul; Rahn Kollander; Hemchandra Mahaseth; Xiao-du Liu; Anna Solovey; John D Belcher; Robert J Kelm; Gregory M Vercellotti; Robert P Hebbel
Robust vascular protective effect of hydroxamic acid derivatives in a sickle mouse model of inflammation.
Microcirculation (New York, N.Y. : 1994) 2006;13(6):489-97.
2006: Julio P Juncos; Joseph P Grande; Narayana S Murali; Anthony J Croatt; Luis A Juncos; Robert P Hebbel; Zvonimir S Katusic; Karl A Nath
Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease.
The American journal of pathology 2006;169(1):21-31.
2006: Simon F De Meyer; Karen Vanhoorelbeke; Marinee K L Chuah; Inge Pareyn; Veerle Gillijns; Robert P Hebbel; Désiré Collen; Hans Deckmyn; Thierry VandenDriessche
Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor.
Blood 2006;107(12):4728-36.
2006: Katherine C Wood; Robert P Hebbel; David J Lefer; D Neil Granger
Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction.
Free radical biology & medicine 2006;40(8):1443-53.
2006: John D Belcher; Hemchandra Mahaseth; Thomas E Welch; Leo E Otterbein; Robert P Hebbel; Gregory M Vercellotti
Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice.
The Journal of clinical investigation 2006;116(3):808-16.
2006: Stanley J Stachelek; Ivan Alferiev; Jeanne M Connolly; Michael Sacks; Robert P Hebbel; Richard Bianco; Robert J Levy
Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo.
The Annals of thoracic surgery 2006;81(1):47-55.
2005: Africa Fernandez-L; Francisco Sanz-Rodriguez; Roberto Zarrabeitia; Alfonso Pérez-Molino; Robert P Hebbel; Julia Nguyen; Carmelo Bernabéu; Luisa M Botella
Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions.
Cardiovascular research 2005;68(2):235-48.
2005: Alisha L Sieminski; Robert P Hebbel; Keith J Gooch
Improved microvascular network in vitro by human blood outgrowth endothelial cells relative to vessel-derived endothelial cells.
Tissue engineering 2005;11(9-10):1332-45.
2005: Katherine C Wood; Robert P Hebbel; D Neil Granger
Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):989-91.
2005: John D Belcher; Hemchandra Mahaseth; Thomas E Welch; Asa E Vilback; Khalid M Sonbol; Venkatasubramaniam S Kalambur; Paul R Bowlin; John C Bischof; Robert P Hebbel; Gregory M Vercellotti
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice.
American journal of physiology. Heart and circulatory physiology 2005;288(6):H2715-25.
2005: Hemchandra Mahaseth; Gregory M Vercellotti; Thomas E Welch; Paul R Bowlin; Khalid M Sonbol; Carleton J C Hsia; Ma Li; John C Bischof; Robert P Hebbel; John D Belcher
Polynitroxyl albumin inhibits inflammation and vasoocclusion in transgenic sickle mice.
The Journal of laboratory and clinical medicine 2005;145(4):204-11.
2005: Karl A Nath; Joseph P Grande; Anthony J Croatt; Elena Frank; Noel M Caplice; Robert P Hebbel; Zvonimir S Katusic
Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury.
The American journal of pathology 2005;166(4):963-72.
2005: Tasneem Poonawala; Brett Levay-Young; Robert P Hebbel; Kalpna Gupta
Opioids heal ischemic wounds in the rat.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2005;13(2):165-74.
2005: Andrew D Blann; Alexander Woywodt; Francesco Bertolini; Todd M Bull; Jill P Buyon; Robert M Clancy; Marion Haubitz; Robert P Hebbel; Gregory Y H Lip; Patrizia Mancuso; Jose Sampol; Anna Solovey; Françoise Dignat-George
Circulating endothelial cells. Biomarker of vascular disease.
Thrombosis and haemostasis 2005;93(2):228-35.
2005: Stanley J Stachelek; Ivan Alferiev; Hoon Choi; Allyson Kronsteiner; Pimporn Uttayarat; Keith J Gooch; Russell J Composto; I-Wei Chen; Robert P Hebbel; Robert J Levy
Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion.
Journal of biomedical materials research. Part A 2005;72(2):200-12.
2004: Wenche Jy; Lawrence L Horstman; Joaquin J Jimenez; Yeon S Ahn; Eva Biró; Rienk Nieuwland; Augueste Sturk; Françoise Dignat-George; Florence Sabatier; Laurence Camoin-Jau; José Sampol; Bénédicte Hugel; Fatiha Zobairi; Jean-Marie Freyssinet; S Nomura; Arun Shet; Nigel S Key; Robert P Hebbel
Measuring circulating cell-derived microparticles.
Journal of thrombosis and haemostasis : JTH 2004;2(10):1842-51.
2004: Venkatasubramaniam S Kalambur; Hemchandra Mahaseth; John C Bischof; Miroslaw C Kielbik; Thomas E Welch; Asa Vilbäck; David J Swanlund; Robert P Hebbel; John D Belcher; Gregory M Vercellotti
Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy.
American journal of hematology 2004;77(2):117-25.
2004: Yi-Feng Xia; Bu-Qing Ye; Yi-Dan Li; Jian-Guo Wang; Xiang-jiu He; Xianfeng Lin; Xinsheng Yao; Dawei Ma; Arne Slungaard; Robert P Hebbel; Nigel S Key; Jian-Guo Geng
Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):4207-17.
2004: Anna Solovey; Rahn Kollander; Arun Shet; Liming C Milbauer; Stephana Choong; Angela Panoskaltsis-Mortari; Bruce R Blazar; Robert J Kelm; Robert P Hebbel
Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin.
Blood 2004;104(3):840-6.
2004: Alisha L Sieminski; Robert P Hebbel; Keith J Gooch
The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro.
Experimental cell research 2004;297(2):574-84.
2004: Dhananjay K Kaul; Xiao-du Liu; Stephana Choong; John D Belcher; Gregory M Vercellotti; Robert P Hebbel
Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice.
American journal of physiology. Heart and circulatory physiology 2004;287(1):H293-301.
2004: Aras Omer; Arun Shet; Ronald R Bach; Jessica L Hysjulien; Arne Slungaard; Robert P Hebbel; Gines Escolar; Bernd Jilma; Nigel S Key
Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia.
Blood 2004;103(12):4545-53.
2004: Katherine Wood; Janice Russell; Robert P Hebbel; D Neil Granger
Differential expression of E- and P-selectin in the microvasculature of sickle cell transgenic mice.
Microcirculation (New York, N.Y. : 1994) 2004;11(4):377-85.
2004: Katherine C Wood; Robert P Hebbel; D Neil Granger
Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1608-14.
2004: Robert P Hebbel; Raymond Osarogiagbon; Dhananjay K Kaul
The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy.
Microcirculation (New York, N.Y. : 1994) 2004;11(2):129-51.
2004: Robert P Hebbel
Special issue of Microcirculation: examination of the vascular pathobiology of sickle cell anemia. Foreword.
Microcirculation (New York, N.Y. : 1994) 2004;11(2):99-100.
2004: Swati Nagar; Rory P Remmel; Robert P Hebbel; Cheryl L Zimmerman
Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(1):98-104.
2003: Todd M Bull; Heiko A Golpon; Robert P Hebbel; Anna Solovey; Carlyne D Cool; Rubin M Tuder; Mark W Geraci; Norbert F Voelkel
Circulating endothelial cells in pulmonary hypertension.
Thrombosis and haemostasis 2003;90(4):698-703.
2003: Arun Shet; Aras Omer; Kalpna Gupta; Mathew J Hass; Douglas Rausch; Nabil Saba; Louann Koopmeiners; Nigel S Key; Robert P Hebbel
Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes.
Blood 2003;102(7):2678-83.
2003: John D Belcher; Christopher J Bryant; Julia Nguyen; Paul R Bowlin; Miroslaw C Kielbik; John C Bischof; Robert P Hebbel; Gregory M Vercellotti
Transgenic sickle mice have vascular inflammation.
Blood 2003;101(10):3953-9.
2003: Christopher E D Lamming; Lance Augustin; Mark Blackstad; Troy Lund; Robert P Hebbel; Catherine M Verfaillie
Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis.
The Journal of clinical investigation 2003;111(6):811-9.
2003: Robert P Hebbel
Sickle hemoglobin instability: a mechanism for malarial protection.
Redox report : communications in free radical research 2003;8(5):238-40.
2002: Patricia E Burger; Sandra Coetzee; Wallace L McKeehan; Mikio Kan; Perry Cook; Yong Fan; Toshio Suda; Robert P Hebbel; Nicolas Novitzky; William A Muller; E Lynette Wilson
Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.
Blood 2002;100(10):3527-35.
2002: Kalpna Gupta; Smita Kshirsagar; Liming Chang; Robert Schwartz; Ping-Y Law; Doug Yee; Robert P Hebbel
Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth.
Cancer research 2002;62(15):4491-8.
2002: Yi Lin; Liming Chang; Anna Solovey; John Francis Healey; Pete Lollar; Robert P Hebbel
Use of blood outgrowth endothelial cells for gene therapy for hemophilia A.
Blood 2002;99(2):457-62.
2001: Anna Solovey; L Gui; L Chang; J Enenstein; P V Browne; Robert P Hebbel
Identification and functional assessment of endothelial P1H12.
The Journal of laboratory and clinical medicine 2001;138(5):322-31.
2001: A A Solovey; Anna Solovey; J Harkness; Robert P Hebbel
Modulation of endothelial cell activation in sickle cell disease: a pilot study.
Blood 2001;97(7):1937-41.
2001: Karl A Nath; JP Grande; Jill J Haggard; Anthony J Croatt; Z S Katusic; Anna Solovey; Robert P Hebbel
Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease.
The American journal of pathology 2001;158(3):893-903.
2001: Muhit Ozcan; C T Morton; Anna Solovey; Luke Dandelet; Ronald R Bach; Robert P Hebbel; Arne Slungaard; Nigel S Key
Whole blood tissue factor procoagulant activity remains detectable during severe aplasia following bone marrow and peripheral blood stem cell transplantation.
Thrombosis and haemostasis 2001;85(2):250-5.
2000: Karl A Nath; V Shah; Jill J Haggard; Anthony J Croatt; L A Smith; Robert P Hebbel; Z S Katusic
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(6):R1949-55.
2000: Yutaka Niihara; Oded Shalev; Robert P Hebbel; H Wu; A Tu; DS Akiyama; Kouichi R Tanaka
Desferrioxamine (DFO) conjugated with starch decreases NAD redox potential of intact red blood cells (RBC): evidence for DFO as an extracellular inducer of oxidant stress in RBC.
American journal of hematology 2000;65(4):281-4.
2000: John D Belcher; Paul H Marker; J P Weber; Robert P Hebbel; Gregory M Vercellotti
Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion.
Blood 2000;96(7):2451-9.
2000: Dhananjay K Kaul; Robert P Hebbel
Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice.
The Journal of clinical investigation 2000;106(3):411-20.
2000: U R Osarogiagbon; Stephana Choong; John D Belcher; Gregory M Vercellotti; MS Paller; Robert P Hebbel
Reperfusion injury pathophysiology in sickle transgenic mice.
Blood 2000;96(1):314-20.
2000: Y Lin; D J Weisdorf; Anna Solovey; Robert P Hebbel
Origins of circulating endothelial cells and endothelial outgrowth from blood.
The Journal of clinical investigation 2000;105(1):71-7.
1999: Oded Shalev; D Hileti; P Nortey; Robert P Hebbel; V A Hoffbrand
Transport of 14C-deferiprone in normal, thalassaemic and sickle red blood cells.
British journal of haematology 1999;105(4):1081-3.
1999: John D Belcher; Paul H Marker; PG Geiger; A W Girotti; M H Steinberg; Robert P Hebbel; Gregory M Vercellotti
Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia.
The Journal of laboratory and clinical medicine 1999;133(6):605-12.
1999: Anna Solovey; L Gui; S Ramakrishnan; M H Steinberg; Robert P Hebbel
Sickle cell anemia as a possible state of enhanced anti-apoptotic tone: survival effect of vascular endothelial growth factor on circulating and unanchored endothelial cells.
Blood 1999;93(11):3824-30.
1999: K Gupta; S Kshirsagar; W Li; L Gui; S Ramakrishnan; Pankaj Gupta; P Y Law; Robert P Hebbel
VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling.
Experimental cell research 1999;247(2):495-504.
1999: K Gupta; Pankaj Gupta; Anna Solovey; Robert P Hebbel
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Biochimica et biophysica acta 1999;1453(1):63-73.
1999: Lucia De Franceschi; Oded Shalev; Antonio Piga; M Collell; Oliviero Olivieri; Roberto Corrocher; Robert P Hebbel; Carlo Brugnara
Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl cotransport activity.
The Journal of laboratory and clinical medicine 1999;133(1):64-9.
1998: L Cragg; Robert P Hebbel; Wesley J Miller; Anna Solovey; S Selby; H Enright
The iron chelator L1 potentiates oxidative DNA damage in iron-loaded liver cells.
Blood 1998;92(2):632-8.
1998: Anna Solovey; L Gui; Nigel S Key; Robert P Hebbel
Tissue factor expression by endothelial cells in sickle cell anemia.
The Journal of clinical investigation 1998;101(9):1899-904.
1998: K Sheng; M Shariff; Robert P Hebbel
Comparative oxidation of hemoglobins A and S.
Blood 1998;91(9):3467-70.
1998: Paul V Browne; Oded Shalev; Robert P Hebbel
The molecular pathobiology of cell membrane iron: the sickle red cell as a model.
Free radical biology & medicine 1998;24(6):1040-8.
1998: J Enenstein; K Gupta; G M Vercellotti; Robert P Hebbel
Thrombin-stimulated calcium mobilization is inhibited by thrombospondin via CD36.
Experimental cell research 1998;238(2):465-71.
1998: Karl A Nath; JP Grande; Anthony J Croatt; S Likely; Robert P Hebbel; H Enright
Intracellular targets in heme protein-induced renal injury.
Kidney international 1998;53(1):100-11.
1997: Robert P Hebbel
Adhesive interactions of sickle erythrocytes with endothelium.
The Journal of clinical investigation 1997;100(11 Suppl):S83-6.
1997: Anna Solovey; Y Lin; Paul V Browne; Stephana Choong; E Wayner; Robert P Hebbel
Circulating activated endothelial cells in sickle cell anemia.
The New England journal of medicine 1997;337(22):1584-90.
1997: Paul V Browne; Oded Shalev; Frans A Kuypers; Carlo Brugnara; Anna Solovey; Narla Mohandas; Stanley L Schrier; Robert P Hebbel
Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia.
The Journal of clinical investigation 1997;100(6):1459-64.
1997: Robert P Hebbel
Perspectives series: cell adhesion in vascular biology. Adhesive interactions of sickle erythrocytes with endothelium.
The Journal of clinical investigation 1997;99(11):2561-4.
1997: Robert P Hebbel; Gregory M Vercellotti
The endothelial biology of sickle cell disease.
The Journal of laboratory and clinical medicine 1997;129(3):288-93.
1997: K Gupta; S Ramakrishnan; Paul V Browne; Anna Solovey; Robert P Hebbel
A novel technique for culture of human dermal microvascular endothelial cells under either serum-free or serum-supplemented conditions: isolation by panning and stimulation with vascular endothelial growth factor.
Experimental cell research 1997;230(2):244-51.
1996: O Shalev; Robert P Hebbel
Extremely high avidity association of Fe(III) with the sickle red cell membrane.
Blood 1996;88(1):349-52.
1996: H Enright; Wesley J Miller; R Hays; R A Floyd; Robert P Hebbel
Preferential targeting of oxidative base damage to internucleosomal DNA.
Carcinogenesis 1996;17(5):1175-7.
1996: P V Browne; D F Mosher; M H Steinberg; Robert P Hebbel
Disturbance of plasma and platelet thrombospondin levels in sickle cell disease.
American journal of hematology 1996;51(4):296-301.
1995: O Shalev; T Repka; A Goldfarb; L Grinberg; A Abrahamov; N F Olivieri; E A Rachmilewitz; Robert P Hebbel
Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo.
Blood 1995;86(5):2008-13.
1995: Karl A Nath; EO Ngo; Robert P Hebbel; Anthony J Croatt; B Zhou; LM Nutter
alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity.
The American journal of physiology 1995;268(1 Pt 1):C227-36.
1994: H Enright; Robert P Hebbel; Karl A Nath
Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual.
The Journal of laboratory and clinical medicine 1994;124(1):63-8.
1994: H Enright; Karl A Nath; Robert P Hebbel
Internucleosomal cleavage of DNA is insufficient evidence to conclude that cell death is apoptotic.
Blood 1994;83(7):2005-7.
1994: E Marva; Robert P Hebbel
Denaturing interaction between sickle hemoglobin and phosphatidylserine liposomes.
Blood 1994;83(1):242-9.
1994: Karl A Nath; H Enright; LM Nutter; M Fischereder; J N Zou; Robert P Hebbel
Effect of pyruvate on oxidant injury to isolated and cellular DNA.
Kidney international 1994;45(1):166-76.
1993: T Repka; O Shalev; R Reddy; J Yuan; A Abrahamov; E A Rachmilewitz; P S Low; Robert P Hebbel
Nonrandom association of free iron with membranes of sickle and beta-thalassemic erythrocytes.
Blood 1993;82(10):3204-10.
1993: T Sugihara; G Rao; Robert P Hebbel
Diphenylamine: an unusual antioxidant.
Free radical biology & medicine 1993;14(4):381-7.
1993: Mark D Scott; J J van den Berg; T Repka; Philippe Rouyer-Fessard; Robert P Hebbel; Y Beuzard; Bertram H Lubin
Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes.
The Journal of clinical investigation 1993;91(4):1706-12.
1992: T Sugihara; T Repka; Robert P Hebbel
Detection, characterization, and bioavailability of membrane-associated iron in the intact sickle red cell.
The Journal of clinical investigation 1992;90(6):2327-32.
1992: K Sugihara; T Sugihara; N Mohandas; Robert P Hebbel
Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells.
Blood 1992;80(10):2634-42.
1992: T Sugihara; Robert P Hebbel
Exaggerated cation leak from oxygenated sickle red blood cells during deformation: evidence for a unique leak pathway.
Blood 1992;80(9):2374-8.
1992: H U Enright; Wesley J Miller; Robert P Hebbel
Nucleosomal histone protein protects DNA from iron-mediated damage.
Nucleic acids research 1992;20(13):3341-6.
1992: T Sugihara; K Sugihara; Robert P Hebbel
Phospholipid asymmetry during erythrocyte deformation: maintenance of the unit membrane.
Biochimica et biophysica acta 1992;1103(2):303-6.
1991: T Repka; Robert P Hebbel
Hydroxyl radical formation by sickle erythrocyte membranes: role of pathologic iron deposits and cytoplasmic reducing agents.
Blood 1991;78(10):2753-8.
1991: Robert P Hebbel; N Mohandas
Reversible deformation-dependent erythrocyte cation leak. Extreme sensitivity conferred by minimal peroxidation.
Biophysical journal 1991;60(3):712-5.
1991: T Sugihara; W Rawicz; E A Evans; Robert P Hebbel
Lipid hydroperoxides permit deformation-dependent leak of monovalent cation from erythrocytes.
Blood 1991;77(12):2757-63.
1991: Robert P Hebbel
Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology.
Blood 1991;77(2):214-37.
1990: Robert P Hebbel; A Leung; N Mohandas
Oxidation-induced changes in microrheologic properties of the red blood cell membrane.
Blood 1990;76(5):1015-20.
1990: P A Ney; M M Christopher; Robert P Hebbel
Synergistic effects of oxidation and deformation on erythrocyte monovalent cation leak.
Blood 1990;75(5):1192-8.
1989: Robert P Hebbel; P A Ney; W Foker
Autoxidation, dehydration, and adhesivity may be related abnormalities of sickle erythrocytes.
The American journal of physiology 1989;256(3 Pt 1):C579-83.
1989: S A Kuross; B H Rank; Robert P Hebbel
Iron compartments associated with sickle RBC membranes: a mechanism for the targeting of oxidative damage.
Progress in clinical and biological research 1989;319():601-10; discussion 611-3.
1988: Robert P Hebbel; Wesley J Miller
Unique promotion of erythrophagocytosis by malondialdehyde.
American journal of hematology 1988;29(4):222-5.
1988: S A Kuross; Robert P Hebbel
Nonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidation.
Blood 1988;72(4):1278-85.
1988: B H Rank; N L Moyer; Robert P Hebbel
Vesiculation of sickle erythrocytes during thermal stress.
Blood 1988;72(3):1060-3.
1988: S A Kuross; B H Rank; Robert P Hebbel
Excess heme in sickle erythrocyte inside-out membranes: possible role in thiol oxidation.
Blood 1988;71(4):876-82.
1988: Robert P Hebbel; W T Morgan; J W Eaton; B E Hedlund
Accelerated autoxidation and heme loss due to instability of sickle hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(1):237-41.
1987: Robert P Hebbel; M R Visser; Jesse Goodman; H S Jacob; Gregory M Vercellotti
Potentiated adherence of sickle erythrocytes to endothelium infected by virus.
The Journal of clinical investigation 1987;80(5):1503-6.
1986: Robert P Hebbel; O Shalev; W Foker; B H Rank
Inhibition of erythrocyte Ca2+-ATPase by activated oxygen through thiol- and lipid-dependent mechanisms.
Biochimica et biophysica acta 1986;862(1):8-16.
1985: B H Rank; J Carlsson; Robert P Hebbel
Abnormal redox status of membrane-protein thiols in sickle erythrocytes.
The Journal of clinical investigation 1985;75(5):1531-7.
1984: B H Rank; Robert P Hebbel; J Carlsson
Oxidation of membrane thiols in sickle erythrocytes.
Progress in clinical and biological research 1984;165():473-7.