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Matthias Hebrok

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TOP 3
Ben Z Stanger; Matthias Hebrok
Control of cell identity in pancreas development and regeneration.
Tingxia Guo; Limor Landsman; Na Li; Matthias Hebrok
Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs.
Wan-chi Lin; Chengbao Liu; John P Morris; Rene Opavsky; Nirakar Rajbhandari; Hallgeir Rui; Kazuhito Sakamoto; Aleata A Triplett; Surinder K Batra; Jonathan R Brody; Dominick J DiMaio; Dean W Felsher; Matthias Hebrok; Michael A Hollingsworth; Agnieszka K Witkiewicz; Qian Zhang; Kay-Uwe Wagner
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

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All Publications

2013: Ben Z Stanger; Matthias Hebrok
Control of cell identity in pancreas development and regeneration.
Gastroenterology 2013;144(6):1170-9.
2013: Tingxia Guo; Limor Landsman; Na Li; Matthias Hebrok
Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs.
Diabetes 2013;62(5):1581-92.
2013: Wan-chi Lin; Chengbao Liu; John P Morris; Rene Opavsky; Nirakar Rajbhandari; Hallgeir Rui; Kazuhito Sakamoto; Aleata A Triplett; Surinder K Batra; Jonathan R Brody; Dominick J DiMaio; Dean W Felsher; Matthias Hebrok; Michael A Hollingsworth; Agnieszka K Witkiewicz; Qian Zhang; Kay-Uwe Wagner
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.
Cancer research 2013;73(6):1821-30.
2013: Marina Pasca di Magliano; Pankaj J Pasricha; Ashok Saluja; Jose Serrano; Ben Z Stanger; Christopher Forsmark; Steven Freedman; Matthias Hebrok; Jane Holt; Stephen P James; Anil K Rustgi
Advances in acute and chronic pancreatitis: from development to inflammation and repair.
Gastroenterology 2013;144(1):e1-4.
2012: Janel L Kopp; Fen-Fen Liu; Erin Mayes; John P Morris; Fong Cheng Pan; Haruhiko Akiyama; Claire L Dubois; Matthias Hebrok; Kristin Jensen; Guido von Figura; Christopher V E Wright; Maike Sander
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.
Cancer cell 2012;22(6):737-50.
2012: Sapna Puri; Matthias Hebrok
Diabetic β Cells: To Be or Not To Be?
Cell 2012;150(6):1103-4.
2012: Akihisa Fukuda; John P Morris; Matthias Hebrok
Bmi1 is required for regeneration of the exocrine pancreas in mice.
Gastroenterology 2012;143(3):821-31.e1-2.
2012: Matthias Hebrok
Generating β cells from stem cells-the story so far.
Cold Spring Harbor perspectives in medicine 2012;2(6):a007674.
2012: Han Qin; Grace Wei; Ru-Fang Yeh; Jingwei Yu; Kathryn Blaschke; Laure Blouin; Matthias Hebrok; Yuki Ohi; Zhongxia Qi; Miguel Ramalho-Santos
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.
Human molecular genetics 2012;21(9):2054-67.
2011: Limor Landsman; Audrey Parent; Matthias Hebrok
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17010-5.
2011: Limor Landsman; Tippi C Mackenzie; Amar Nijagal; Renee L Vanderlaan; Theresa J Whitchurch; Warren E Zimmer; Matthias Hebrok
Pancreatic mesenchyme regulates epithelial organogenesis throughout development.
PLoS biology 2011;9(9):e1001143.
2011: Mark A Atkinson; Jeffrey A Bluestone; George S Eisenbarth; Matthias Hebrok; Kevan C Herold; Domenico Accili; Massimo Pietropaolo; Peter Arvan; Matthias Von Herrath; Dorene S Markel; Christopher J Rhodes
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.
Diabetes 2011;60(5):1370-9.
2011: Yuki Ohi; Han Qin; Chibo Hong; Laure Blouin; Jose M Polo; Tingxia Guo; Zhongxia Qi; Sara L Downey; Philip D Manos; Derrick J Rossi; Jingwei Yu; Matthias Hebrok; Konrad Hochedlinger; Joseph F Costello; Jun S Song; Miguel Ramalho-Santos
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.
Nature cell biology 2011;13(5):541-9.
2011: Akihisa Fukuda; Sam C Wang; John P Morris; Alexandra E Folias; Ally P Liou; Grace E Kim; Shizuo Akira; Kenneth M Boucher; Matthew A Firpo; Sean J Mulvihill; Matthias Hebrok
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Cancer cell 2011;19(4):441-55.
2010: John P Morris; Sam C Wang; Matthias Hebrok
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.
Nature reviews. Cancer 2010;10(10):683-95.
2010: Lutz Kockel; Kimberly S Kerr; Michael Melnick; Katja Brückner; Matthias Hebrok; Norbert Perrimon
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.
PLoS genetics 2010;6(6):e1000990.
2010: Sara Cervantes; Janet Lau; David A Cano; Cecilia Borromeo-Austin; Matthias Hebrok
Primary cilia regulate Gli/Hedgehog activation in pancreas.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10109-14.
2010: Janet Lau; Matthias Hebrok
Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function.
Diabetes 2010;59(5):1211-21.
2010: Sapna Puri; Matthias Hebrok
Cellular plasticity within the pancreas--lessons learned from development.
Developmental cell 2010;18(3):342-56.
2010: John P Morris; David A Cano; Shigeki Sekine; Sam C Wang; Matthias Hebrok
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
The Journal of clinical investigation 2010;120(2):508-20.
2009: John P Morris; Matthias Hebrok
It's a free for all--insulin-positive cells join the group of potential progenitors for pancreatic ductal adenocarcinoma.
Cancer cell 2009;16(5):359-61.
2009: Shigeki Sekine; Reiko Ogawa; Michael McManus; Yae Kanai; Matthias Hebrok
Dicer is required for proper liver zonation.
The Journal of pathology 2009;219(3):365-72.
2009: Shigeki Sekine; Reiko Ogawa; Rie Ito; Nobuyoshi Hiraoka; Michael McManus; Yae Kanai; Matthias Hebrok
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis.
Gastroenterology 2009;136(7):2304-2315.e1-4.
2009: Tingxia Guo; Matthias Hebrok
Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy.
Endocrine reviews 2009;30(3):214-27.
2009: Sara Cervantes; Terry P Yamaguchi; Matthias Hebrok
Wnt5a is essential for intestinal elongation in mice.
Developmental biology 2009;326(2):285-94.
2009: Sapna Puri; David A Cano; Matthias Hebrok
A role for von Hippel-Lindau protein in pancreatic beta-cell function.
Diabetes 2009;58(2):433-41.
2009: Olivier Nolan-Stevaux; Janet Lau; Morgan L Truitt; Gerald Chu; Matthias Hebrok; Martin E Fernández-Zapico; Douglas Hanahan
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Genes & development 2009;23(1):24-36.
2008: Patrick W Heiser; David A Cano; Limor Landsman; Grace E Kim; James G Kench; David S Klimstra; Makoto M Taketo; Andrew V Biankin; Matthias Hebrok
Stabilization of beta-catenin induces pancreas tumor formation.
Gastroenterology 2008;135(4):1288-300.
2008: David A Cano; Matthias Hebrok
Hedgehog spikes pancreas regeneration.
Gastroenterology 2008;135(2):347-51.
2008: David A Cano; Ingrid C Rulifson; Patrick W Heiser; Lamorna Brown Swigart; Stella Pelengaris; Michael S German; Gerard I Evan; Jeffrey A Bluestone; Matthias Hebrok
Regulated beta-cell regeneration in the adult mouse pancreas.
Diabetes 2008;57(4):958-66.
2008: Jeffrey A Bluestone; Matthias Hebrok
Safer, longer-lasting regulatory T cells with beta-catenin.
Nature medicine 2008;14(2):118-9.
2007: R E Burris; Matthias Hebrok
Pancreatic innervation in mouse development and beta-cell regeneration.
Neuroscience 2007;150(3):592-602.
2007: Jean B Regard; Hiroshi Kataoka; David A Cano; Eric Camerer; Liya Yin; Yao-Wu Zheng; Thomas S Scanlan; Matthias Hebrok; Shaun R Coughlin
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.
The Journal of clinical investigation 2007;117(12):4034-43.
2007: Sapna Puri; Matthias Hebrok
Dynamics of embryonic pancreas development using real-time imaging.
Developmental biology 2007;306(1):82-93.
2007: David J. Robbins; Matthias Hebrok
Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli Signaling in Cancer and Stem Cells.
EMBO reports 2007;8(5):451-5.
2007: Ingrid C Rulifson; Satyajit K Karnik; Patrick W Heiser; Derk ten Berge; Hainan Chen; Xueying Gu; Makoto M Taketo; Roel Nusse; Matthias Hebrok; Seung K Kim
Wnt signaling regulates pancreatic beta cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6247-52.
2007: Jennifer P Morton; Michelle E Mongeau; David S Klimstra; John P Morris; Yie Chia Lee; Yoshiya Kawaguchi; Christopher V E Wright; Matthias Hebrok; Brian C Lewis
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5103-8.
2007: David A Cano; Matthias Hebrok; Martin Zenker
Pancreatic development and disease.
Gastroenterology 2007;132(2):745-62.
2007: Shigeki Sekine; Pedro J A Gutiérrez; Billy Yu-Ang Lan; Sandy Feng; Matthias Hebrok
Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.
Hepatology (Baltimore, Md.) 2007;45(2):361-8.
2007: Marina Pasca di Magliano; Andrew V Biankin; Patrick W Heiser; David A Cano; Pedro J A Gutierrez; Therese B Deramaudt; Davendra Segara; Amanda C Dawson; James G Kench; Susan M Henshall; Robert L Sutherland; Andrzej Dlugosz; Anil K Rustgi; Matthias Hebrok
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.
PloS one 2007;2(11):e1155.
2007: Roman Nawroth; Annemieke van Zante; Sara Cervantes; Michael McManus; Matthias Hebrok; Steven D Rosen
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells.
PloS one 2007;2(4):e392.
2006: David A Cano; Shigeki Sekine; Matthias Hebrok
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.
Gastroenterology 2006;131(6):1856-69.
2006: Marina Pasca di Magliano; Shigeki Sekine; Alexandre Ermilov; Jenny Ferris; Andrzej Dlugosz; Matthias Hebrok
Hedgehog/Ras interactions regulate early stages of pancreatic cancer.
Genes & development 2006;20(22):3161-73.
2006: Patrick W Heiser; Janet Lau; Makoto M Taketo; Pedro L Herrera; Matthias Hebrok
Stabilization of beta-catenin impacts pancreas growth.
Development (Cambridge, England) 2006;133(10):2023-32.
2006: Shigeki Sekine; Billy Yu-Ang Lan; Melanie Bedolli; Sandy Feng; Matthias Hebrok
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.
Hepatology (Baltimore, Md.) 2006;43(4):817-25.
2006: J Lau; Hiroshi Kawahira; Matthias Hebrok
Hedgehog signaling in pancreas development and disease.
Cellular and molecular life sciences : CMLS 2006;63(6):642-52.
2005: Hiroshi Kawahira; David W Scheel; Stuart B Smith; Michael S German; Matthias Hebrok
Hedgehog signaling regulates expansion of pancreatic epithelial cells.
Developmental biology 2005;280(1):111-21.
2005: Sabina E Perez; David A Cano; Trang Dao-Pick; Jean-Phillipe Rougier; Zena Werb; Matthias Hebrok
Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.
Diabetes 2005;54(3):694-701.
2004: David A Cano; Noel S Murcia; Gregory Pazour; Matthias Hebrok
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.
Development (Cambridge, England) 2004;131(14):3457-67.
2004: Matthias Hebrok; Louis F Reichardt
Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration.
Trends in cell biology 2004;14(4):153-5.
2004: Patrick W Heiser; Matthias Hebrok
Development and cancer: lessons learned in the pancreas.
Cell cycle (Georgetown, Tex.) 2004;3(3):270-2.
2003: Marina Pasca di Magliano; Matthias Hebrok
Hedgehog signalling in cancer formation and maintenance.
Nature reviews. Cancer 2003;3(12):903-11.
2003: Sarah P Thayer; Marina Pasca di Magliano; Patrick W Heiser; Corinne M Nielsen; Drucilla J Roberts; Gregory Y Lauwers; Yan Ping Qi; Stephan Gysin; Carlos Fernández-del Castillo; Vijay Yajnik; Bozena Antoniu; Martin McMahon; Andrew L Warshaw; Matthias Hebrok
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Nature 2003;425(6960):851-6.
2003: Hiroshi Kawahira; Nancy H Ma; Emmanuel Tzanakakis; Andrew P McMahon; Pao-Tien Chuang; Matthias Hebrok
Combined activities of hedgehog signaling inhibitors regulate pancreas development.
Development (Cambridge, England) 2003;130(20):4871-9.
2003: Matthias Hebrok
Hedgehog signaling in pancreas development.
Mechanisms of development 2003;120(1):45-57.
2001: Stuart K Kim; Matthias Hebrok
Intercellular signals regulating pancreas development and function.
Genes & development 2001;15(2):111-27.
2000: Matthias Hebrok; S K Kim; B St Jacques; Andrew P McMahon; Douglas A Melton
Regulation of pancreas development by hedgehog signaling.
Development (Cambridge, England) 2000;127(22):4905-13.
2000: Stuart K Kim; Matthias Hebrok; En Li; S Paul Oh; Heindrich Schrewe; Erin B Harmon; J S Lee; Douglas A Melton
Activin receptor patterning of foregut organogenesis.
Genes & development 2000;14(15):1866-71.
1999: Matthias Hebrok; S K Kim; Douglas A Melton
Screening for novel pancreatic genes expressed during embryogenesis.
Diabetes 1999;48(8):1550-6.
1998: Matthias Hebrok; S K Kim; Douglas A Melton
Notochord repression of endodermal Sonic hedgehog permits pancreas development.
Genes & development 1998;12(11):1705-13.
1997: S K Kim; Matthias Hebrok; Douglas A Melton
Notochord to endoderm signaling is required for pancreas development.
Development (Cambridge, England) 1997;124(21):4243-52.
1997: S K Kim; Matthias Hebrok; Douglas A Melton
Pancreas development in the chick embryo.
Cold Spring Harbor symposia on quantitative biology 1997;62():377-83.