Stephen Hecht

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Kim Yong Y; Von Weymarn Linda; Larsson Ola; Fan Danhua; Underwood Jon M; Peterson Mark S; Hecht Stephen S; Polunovsky Vitaly A; Bitterman Peter B
Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.
Stepanov Irina; Carmella Steven G; Briggs Anna; Hertsgaard Louise; Lindgren Bruce; Hatsukami Dorothy; Hecht Stephen S
Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products.
Derby Kiersten S; Cuthrell Kristine; Caberto Christian; Carmella Steven; Murphy Sharon E; Hecht Stephen S; Le Marchand Loïc
Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.

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All Publications

2009: Kim Yong Y; Von Weymarn Linda; Larsson Ola; Fan Danhua; Underwood Jon M; Peterson Mark S; Hecht Stephen S; Polunovsky Vitaly A; Bitterman Peter B
Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.
Cancer research 2009;69(21):8455-62.
2009: Stepanov Irina; Carmella Steven G; Briggs Anna; Hertsgaard Louise; Lindgren Bruce; Hatsukami Dorothy; Hecht Stephen S
Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products.
Cancer research 2009;69(21):8236-40.
2009: Derby Kiersten S; Cuthrell Kristine; Caberto Christian; Carmella Steven; Murphy Sharon E; Hecht Stephen S; Le Marchand Loïc
Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.
International journal of cancer. Journal international du cancer 2009;125(10):2418-24.
2009: Wang Mingyao; Cheng Guang; Balbo Silvia; Carmella Steven G; Villalta Peter W; Hecht Stephen S
Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers.
Cancer research 2009;69(18):7170-4.
2009: Hecht Stephen S; Kassie Fekadu; Hatsukami Dorothy K
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers.
Nature reviews. Cancer 2009;9(7):476-88.
2009: Upadhyaya Pramod; Lindgren Bruce R; Hecht Stephen S
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1147-51.
2009: Zhang Siyi; Wang Mingyao; Villalta Peter W; Lindgren Bruce R; Lao Yanbin; Hecht Stephen S
Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine.
Chemical research in toxicology 2009;22(5):949-56.
2009: Zhang Siyi; Wang Mingyao; Villalta Peter W; Lindgren Bruce R; Upadhyaya Pramod; Lao Yanbin; Hecht Stephen S
Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Chemical research in toxicology 2009;22(5):926-36.
2009: Yuan Jian-Min; Koh Woon-Puay; Murphy Sharon E; Fan Yunhua; Wang Renwei; Carmella Steven G; Han Shaomei; Wickham Katie; Gao Yu-Tang; Yu Mimi C; Hecht Stephen S
Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers.
Cancer research 2009;69(7):2990-5.
2009: Carmella Steven G; Chen Menglan; Han Shaomei; Briggs Anna; Jensen Joni; Hatsukami Dorothy K; Hecht Stephen S
Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers.
Chemical research in toxicology 2009;22(4):734-41.
2009: Hecht Stephen S; Berg Jeannette Zinggeler; Hochalter J Bradley
Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer.
Chemical research in toxicology 2009;22(3):426-32.
2009: Stepanov Irina; Hecht Stephen S
Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Chemical research in toxicology 2009;22(2):406-14.
2009: Stepanov Irina; Carmella Steven G; Han Shaomei; Pinto Angela; Strasser Andrew A; Lerman Caryn; Hecht Stephen S
Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2009;11(1):99-105.
2009: Wang Li-Shu; Hecht Stephen S; Carmella Steven G; Yu Nanxiong; Larue Bethany; Henry Cassandra; McIntyre Colleen; Rocha Claudio; Lechner John F; Stoner Gary D
Anthocyanins in black raspberries prevent esophageal tumors in rats.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):84-93.
2009: Church Timothy R; Anderson Kristin E; Caporaso Neil E; Geisser Mindy S; Le Chap T; Zhang Yan; Benoit Adam R; Carmella Steven G; Hecht Stephen S
A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(1):260-6.
2008: Kassie Fekadu; Matise Ilze; Negia Mesfin; Upadhyaya Pramod; Hecht Stephen S
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol.
Cancer prevention research (Philadelphia, Pa.) 2008;1(7):568-76.
2008: Hertsgaard Louise A; Hanson Karen; Hecht Stephen S; Lindgren Bruce R; Luo Xianghua; Carmella Steven G; Riley William T; Zylla Emily B; Murphy Sharon E; Hatsukami Dorothy K
Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(12):3337-43.
2008: Derby Kiersten S; Cuthrell Kristine; Caberto Christian; Carmella Steven G; Franke Adrian A; Hecht Stephen S; Murphy Sharon E; Le Marchand Loïc
Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(12):3526-35.
2008: Stepanov Irina; Jensen Joni; Hatsukami Dorothy; Hecht Stephen S
New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2008;10(12):1773-82.
2008: Johnson Thomas E; Kassie Fekadu; O'Sullivan M Gerard; Negia Mesfin; Hanson Timothy E; Upadhyaya Pramod; Ruvolo Peter P; Hecht Stephen S; Xing Chengguo
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
Cancer prevention research (Philadelphia, Pa.) 2008;1(6):430-8.
2008: Le Marchand Loïc; Derby Kiersten S; Murphy Sharon E; Hecht Stephen S; Hatsukami Dorothy; Carmella Steven G; Tiirikainen Maarit; Wang Hansong
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.
Cancer research 2008;68(22):9137-40.
2008: Balbo Silvia; Hashibe Mia; Gundy Sarolta; Brennan Paul; Canova Cristina; Simonato Lorenzo; Merletti Franco; Richiardi Lorenzo; Agudo Antonio; Castellsagué Xavier; Znaor Ariana; Talamini Renato; Bencko Vladimir; Holcátová Ivana; Wang Mingyao; Hecht Stephen S; Boffetta Paolo
N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(11):3026-32.
2008: Upadhyaya Pramod; Hecht Stephen S
Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA.
Chemical research in toxicology 2008;21(11):2164-71.
2008: Kassie Fekadu; Matise Ilze; Negia Mesfin; Lahti David; Pan Yunqian; Scherber Robyn; Upadhyaya Pramod; Hecht Stephen S
Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice.
Cancer prevention research (Philadelphia, Pa.) 2008;1(4):285-97.
2008: Stepanov Irina; Upadhyaya Pramod; Carmella Steven G; Feuer Rachel; Jensen Joni; Hatsukami Dorothy K; Hecht Stephen S
Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(7):1764-73.
2008: Boffetta Paolo; Hecht Stephen; Gray Nigel; Gupta Prakash; Straif Kurt
Smokeless tobacco and cancer.
The lancet oncology 2008;9(7):667-75.
2008: Upadhyaya Pramod; Kalscheuer Stephen; Hochalter J Bradley; Villalta Peter W; Hecht Stephen S
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Chemical research in toxicology 2008;21(7):1468-76.
2008: Hecht Stephen S; Villalta Peter W; Hochalter J Bradley
Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms.
Carcinogenesis 2008;29(5):937-43.
2008: Stepanov Irina; Hecht Stephen S
Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(4):945-8.
2008: Burns D M; Dybing E; Gray N; Hecht S; Anderson C; Sanner T; O'Connor R; Djordjevic M; Dresler C; Hainaut P; Jarvis M; Opperhuizen A; Straif K
Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal.
Tobacco control 2008;17(2):132-41.
2008: Hecht S S; Carmella S G; Edmonds A; Murphy S E; Stepanov I; Luo X; Hatsukami D K
Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco.
Tobacco control 2008;17(2):128-31.
2008: Hecht Stephen S; Carmella Steven G; Stepanov Irina; Jensen Joni; Anderson Amanda; Hatsukami Dorothy K
Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(3):732-5.
2008: Joseph Anne M; Hecht Stephen S; Murphy Sharon E; Lando Harry; Carmella Steven G; Gross Myron; Bliss Robin; Le Chap T; Hatsukami Dorothy K
Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2008;10(3):471-81.
2008: Cheng Guang; Wang Mingyao; Upadhyaya Pramod; Villalta Peter W; Hecht Stephen S
Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).
Chemical research in toxicology 2008;21(3):746-51.
2008: Kassie Fekadu; Anderson Lorraine B; Higgins Leeann; Pan Yunqian; Matise Ilze; Negia Mesfin; Upadhyaya Pramod; Wang Mingyao; Hecht Stephen S
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Carcinogenesis 2008;29(3):610-9.
2008: Liu Xiaodan; Moody Emily C; Hecht Stephen S; Sturla Shana J
Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity.
Bioorganic & medicinal chemistry 2008;16(6):3419-27.
2008: Hatsukami Dorothy K; Ebbert Jon O; Edmonds Amanda; Li Casey; Lin Haiying; Le Chap; Hecht Stephen S
Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2008;10(1):77-85.
2008: Hecht Stephen S
Progress and challenges in selected areas of tobacco carcinogenesis.
Chemical research in toxicology 2008;21(1):160-71.
2007: Mendoza-Baumgart M Irene; Tulunay Ozlem E; Hecht Stephen S; Zhang Yan; Murphy Sharon; Le Chap; Jensen Joni; Hatsukami Dorothy K
Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2007;9(12):1309-23.
2007: Hatsukami Dorothy K; Ebbert Jon O; Feuer Rachel M; Stepanov Irina; Hecht Stephen S
Changing smokeless tobacco products new tobacco-delivery systems.
American journal of preventive medicine 2007;33(6 Suppl):S368-78.
2007: Hatsukami Dorothy K; Joseph Anne M; Lesage Mark; Jensen Joni; Murphy Sharon E; Pentel Paul R; Kotlyar Michael; Borgida Eugene; Le Chap; Hecht Stephen S
Developing the science base for reducing tobacco harm.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2007;9 Suppl 4():S537-53.
2007: Chen Li; Wang Mingyao; Villalta Peter W; Hecht Stephen S
Liquid chromatography-electrospray ionization tandem mass spectrometry analysis of 7-ethylguanine in human liver DNA.
Chemical research in toxicology 2007;20(10):1498-502.
2007: Stoner Gary D; Wang Li-Shu; Zikri Nancy; Chen Tong; Hecht Stephen S; Huang Chuanshu; Sardo Christine; Lechner John F
Cancer prevention with freeze-dried berries and berry components.
Seminars in cancer biology 2007;17(5):403-10.
2007: Spector Logan G; Hecht Stephen S; Ognjanovic Simona; Carmella Steven G; Ross Julie A
Detection of cotinine in newborn dried blood spots.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(9):1902-5.
2007: Lubin Jay H; Caporaso Neil; Hatsukami Dorothy K; Joseph Anne M; Hecht Stephen S
The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(9):1852-7.
2007: Hecht Stephen S; Carmella Steven G; Murphy Sharon E; Riley William T; Le Chap; Luo Xianghua; Mooney Marc; Hatsukami Dorothy K
Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(8):1567-72.
2007: Wang Mingyao; Cheng Guang; Villalta Peter W; Hecht Stephen S
Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Chemical research in toxicology 2007;20(8):1141-8.
2007: Porubin Diana; Hecht Stephen S; Li Zhong-ze; Gonta Maria; Stepanov Irina
Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract.
Journal of agricultural and food chemistry 2007;55(17):7199-204.
2007: Stark Michael J; Rohde Kristen; Maher Julie E; Pizacani Barbara A; Dent Clyde W; Bard Ronda; Carmella Steven G; Benoit Adam R; Thomson Nicole M; Hecht Stephen S
The impact of clean indoor air exemptions and preemption policies on the prevalence of a tobacco-specific lung carcinogen among nonsmoking bar and restaurant workers.
American journal of public health 2007;97(8):1457-63.
2007: Stepanov Irina; Hecht Stephen S; Lindgren Bruce; Jacob Peyton; Wilson Margaret; Benowitz Neal L
Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(7):1382-6.
2007: Kassie Fekadu; Anderson Lorraine B; Scherber Robyn; Yu Nanxiong; Lahti David; Upadhyaya Pramod; Hecht Stephen S
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.
Cancer research 2007;67(13):6502-11.
2007: Carmella Steven G; Chen Menglan; Zhang Yan; Zhang Siyi; Hatsukami Dorothy K; Hecht Stephen S
Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking.
Chemical research in toxicology 2007;20(7):986-90.
2007: McNiel Elizabeth A; Carmella Steven G; Heath Lori A; Bliss Robin L; Le Ky-Anh; Hecht Stephen S
Urinary biomarkers to assess exposure of cats to environmental tobacco smoke.
American journal of veterinary research 2007;68(4):349-53.
2007: Wang Mingyao; Lao Yanbin; Cheng Guang; Shi Yongli; Villalta Peter W; Nishikawa Akiyoshi; Hecht Stephen S
Analysis of adducts in hepatic DNA of rats treated with N-nitrosopyrrolidine.
Chemical research in toxicology 2007;20(4):634-40.
2007: Wang Mingyao; Lao Yanbin; Cheng Guang; Shi Yongli; Villalta Peter W; Hecht Stephen S
Identification of adducts formed in the reaction of alpha-acetoxy-N-nitrosopyrrolidine with deoxyribonucleosides and DNA.
Chemical research in toxicology 2007;20(4):625-33.
2007: Zhang Siyi; Villalta Peter W; Wang Mingyao; Hecht Stephen S
Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Chemical research in toxicology 2007;20(4):565-71.
2007: Hecht Stephen S; Han Shaomei; Kenney Patrick M J; Wang Mingyao; Lindgren Bruce; Wang Yong; Lao Yanbin; Hochalter J Bradley; Upadhyaya Pramod
Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats.
Chemical research in toxicology 2007;20(3):543-9.
2007: Hatsukami D K; Ebbert J O; Anderson A; Lin H; Le C; Hecht S S
Smokeless tobacco brand switching: a means to reduce toxicant exposure?
Drug and alcohol dependence 2007;87(2-3):217-24.
2007: Lao Yanbin; Yu Nanxiong; Kassie Fekadu; Villalta Peter W; Hecht Stephen S
Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine.
Chemical research in toxicology 2007;20(2):246-56.
2007: Lao Yanbin; Yu Nanxiong; Kassie Fekadu; Villalta Peter W; Hecht Stephen S
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Chemical research in toxicology 2007;20(2):235-45.
2007: Hatsukami Dorothy; Mooney Marc; Murphy Sharon; LeSage Mark; Babb David; Hecht Stephen
Effects of high dose transdermal nicotine replacement in cigarette smokers.
Pharmacology, biochemistry, and behavior 2007;86(1):132-9.
2007: Chen Li; Wang Mingyao; Villalta Peter W; Luo Xianghua; Feuer Rachel; Jensen Joni; Hatsukami Dorothy K; Hecht Stephen S
Quantitation of an acetaldehyde adduct in human leukocyte DNA and the effect of smoking cessation.
Chemical research in toxicology 2007;20(1):108-13.
2006: Stepanov Irina; Feuer Rachel; Jensen Joni; Hatsukami Dorothy; Hecht Stephen S
Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(12):2378-83.
2006: Hatsukami Dorothy K; Le Chap T; Zhang Ying; Joseph Anne M; Mooney Marc E; Carmella Steven G; Hecht Stephen S
Toxicant exposure in cigarette reducers versus light smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(12):2355-8.
2006: Hecht Stephen S
Cigarette smoking: cancer risks, carcinogens, and mechanisms.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2006;391(6):603-13.
2006: Hecht Stephen S
Smoking and lung cancer--a new role for an old toxicant?
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):15725-6.
2006: Liu Xiang; Lao Yanbin; Yang In-Young; Hecht Stephen S; Moriya Masaaki
Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity.
Biochemistry 2006;45(42):12898-905.
2006: Zhang Siyi; Villalta Peter W; Wang Mingyao; Hecht Stephen S
Analysis of crotonaldehyde- and acetaldehyde-derived 1,n(2)-propanodeoxyguanosine adducts in DNA from human tissues using liquid chromatography electrospray ionization tandem mass spectrometry.
Chemical research in toxicology 2006;19(10):1386-92.
2006: Hecht Stephen S; Carmella Steven G; Yoder Andrea; Chen Menglan; Li Zhong-ze; Le Chap; Dayton Rachel; Jensen Joni; Hatsukami Dorothy K
Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(10):1805-11.
2006: Hecht Stephen S
A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer.
Preventive medicine 2006;43(4):256-60.
2006: Upadhyaya Pramod; Rao Priyanka; Hochalter J Bradley; Li Zhong-Ze; Villalta Peter W; Hecht Stephen S
Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers.
Chemical research in toxicology 2006;19(9):1234-40.
2006: Stein Scott; Lao Yanbin; Yang In-Young; Hecht Stephen S; Moriya Masaaki
Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells.
Mutation research 2006;608(1):1-7.
2006: Hatsukami Dorothy K; Benowitz Neal L; Rennard Stephen I; Oncken Cheryl; Hecht Stephen S
Biomarkers to assess the utility of potential reduced exposure tobacco products.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2006;8(4):600-22.
2006: Carmella Steven G; Yoder Andrea; Hecht Stephen S
Combined analysis of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' plasma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(8):1490-4.
2006: Hecht Stephen S
Re: Foulds and Ramstrom: Cancer Causes and Control 17: 227-228 (2006) and Henley et al., Cancer Causes and Control 16: 347-358 (2005). How smokeless tobacco can cause lung cancer.
Cancer causes & control : CCC 2006;17(6):859-60.
2006: Hecht Stephen S; Huang Chuanshu; Stoner Gary D; Li Jingxia; Kenney Patrick M J; Sturla Shana J; Carmella Steven G
Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity.
Carcinogenesis 2006;27(8):1617-26.
2006: Hecht Stephen S; Carmella Steven G; Le Ky-Anh; Murphy Sharon E; Boettcher Angela J; Le Chap; Koopmeiners Joseph; An Larry; Hennrikus Deborah J
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(5):988-92.
2006: Lao Yanbin; Villalta Peter W; Sturla Shana J; Wang Mingyao; Hecht Stephen S
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
Chemical research in toxicology 2006;19(5):674-82.
2006: Stepanov Irina; Jensen Joni; Hatsukami Dorothy; Hecht Stephen S
Tobacco-specific nitrosamines in new tobacco products.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2006;8(2):309-13.
2006: Hatsukami Dorothy K; Benowitz Neal L; Rennard Stephen I; Oncken Cheryl; Hecht Stephen S
Biomarkers to assess the utility of potential reduced exposure tobacco products.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2006;8(2):169-91.
2006: Upadhyaya Pramod; McIntee Edward J; Villalta Peter W; Hecht Stephen S
Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA.
Chemical research in toxicology 2006;19(3):426-35.
2006: Derave Wim; Vanden Eede Els; Hespel Peter; Carmella Steven G; Hecht Stephen S
Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine.
Nutrition (Burbank, Los Angeles County, Calif.) 2006;22(3):332-3.
2006: Wang Mingyao; Yu Nanxiong; Chen Li; Villalta Peter W; Hochalter J Bradley; Hecht Stephen S
Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine.
Chemical research in toxicology 2006;19(2):319-24.
2006: Stepanov Irina; Hecht Stephen S; Duca Gheorghe; Mardari Igor
Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(1):7-11.
2005: Hecht Stephen S; Chen Menglan; Yoder Andrea; Jensen Joni; Hatsukami Dorothy; Le Chap; Carmella Steven G
Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(12):2969-74.
2005: Joseph Anne M; Hecht Stephen S; Murphy Sharon E; Carmella Steven G; Le Chap T; Zhang Yan; Han Shaomei; Hatsukami Dorothy K
Relationships between cigarette consumption and biomarkers of tobacco toxin exposure.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(12):2963-8.
2005: Hecht Stephen S
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Journal of the National Cancer Institute 2005;97(22):1634-5.
2005: Carmella Steven G; Han Shaomei; Villalta Peter W; Hecht Stephen S
Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' blood.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(11 Pt 1):2669-72.
2005: Kensler Thomas W; Chen Jian-Guo; Egner Patricia A; Fahey Jed W; Jacobson Lisa P; Stephenson Katherine K; Ye Lingxiang; Coady Jamie L; Wang Jin-Bing; Wu Yan; Sun Yan; Zhang Qi-Nan; Zhang Bao-Chu; Zhu Yuan-Rong; Qian Geng-Sun; Carmella Stephen G; Hecht Stephen S; Benning Lorie; Gange Stephen J; Groopman John D; Talalay Paul
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(11 Pt 1):2605-13.
2005: Stepanov Irina; Hecht Stephen S; Mirvish Sidney S; Gonta Maria
Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco.
Journal of agricultural and food chemistry 2005;53(20):8082-6.
2005: Conaway C Clifford; Wang Chung-Xiou; Pittman Brian; Yang Yang-Ming; Schwartz Joel E; Tian Defa; McIntee Edward J; Hecht Stephen S; Chung Fung-Lung
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Cancer research 2005;65(18):8548-57.
2005: Hecht Stephen S
Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new.
Carcinogenesis 2005;26(9):1488-92.
2005: Dietrich Marion; Block Gladys; Pogoda Janice M; Buffler Patricia; Hecht Stephen; Preston-Martin Susan
A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors.
Cancer causes & control : CCC 2005;16(6):619-35.
2005: Stepanov Irina; Hecht Stephen S; Ramakrishnan Sreevidya; Gupta Prakash C
Tobacco-specific nitrosamines in smokeless tobacco products marketed in India.
International journal of cancer. Journal international du cancer 2005;116(1):16-9.
2005: Lemmonds Charlotte A; Hecht Stephen S; Jensen Joni A; Murphy Sharon E; Carmella Steven G; Zhang Yan; Hatsukami Dorothy K
Smokeless tobacco topography and toxin exposure.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2005;7(3):469-74.
2005: Sturla Shana J; Scott Jana; Lao Yanbin; Hecht Stephen S; Villalta Peter W
Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Chemical research in toxicology 2005;18(6):1048-55.
2005: Wong Hansen L; Zhang Xiuling; Zhang Qing-Yu; Gu Jun; Ding Xinxin; Hecht Stephen S; Murphy Sharon E
Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.
Chemical research in toxicology 2005;18(6):913-8.
2005: Tulunay Ozlem E; Hecht Stephen S; Carmella Steven G; Zhang Yan; Lemmonds Charlotte; Murphy Sharon; Hatsukami Dorothy K
Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(5):1283-6.
2005: Hecht Stephen; Hatsukami Dorothy
Reducing harm caused by tobacco. Research findings from the University of Minnesota.
Minnesota medicine 2005;88(4):40-3.
2005: Lao Yanbin; Hecht Stephen S
Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link.
Chemical research in toxicology 2005;18(4):711-21.
2005: Kelley Michael J; Glaser Elizabeth M; Herndon James E; Becker Frank; Bhagat Rajesh; Zhang Yu-Jing; Santella Regina M; Carmella Steven G; Hecht Stephen S; Gallot Lilia; Schilder Lawrence; Crowell James A; Perloff Marjorie; Folz Rodney J; Bergan Raymond C
Safety and efficacy of weekly oral oltipraz in chronic smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(4):892-9.
2005: Stepanov Irina; Hecht Stephen S
Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(4):885-91.
2005: Hecht Stephen S; Murphy Sharon E; Carmella Steven G; Li Shelby; Jensen Joni; Le Chap; Joseph Anne M; Hatsukami Dorothy K
Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(3):693-8.
2005: Kim Jee Young; Hecht Stephen S; Mukherjee Sutapa; Carmella Steven G; Rodrigues Ema G; Christiani David C
A urinary metabolite of phenanthrene as a biomarker of polycyclic aromatic hydrocarbon metabolic activation in workers exposed to residual oil fly ash.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(3):687-92.
2005: Jalas John R; Hecht Stephen S; Murphy Sharon E
Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.
Chemical research in toxicology 2005;18(2):95-110.
2005: Wong Hansen L; Murphy Sharon E; Hecht Stephen S
Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.
Chemical research in toxicology 2005;18(1):61-9.
2004: Carmella Steven G; Chen Menglan; Yagi Haruhiko; Jerina Donald M; Hecht Stephen S
Analysis of phenanthrols in human urine by gas chromatography-mass spectrometry: potential use in carcinogen metabolite phenotyping.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(12):2167-74.
2004: Wogan Gerald N; Hecht Stephen S; Felton James S; Conney Allan H; Loeb Lawrence A
Environmental and chemical carcinogenesis.
Seminars in cancer biology 2004;14(6):473-86.
2004: Murphy Sharon E; Link Carrie A; Jensen Joni; Le Chap; Puumala Susan S; Hecht Stephen S; Carmella Steven G; Losey London; Hatsukami Dorothy K
A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(10):1617-23.
2004: Carmella Steven G; Le Ky-Anh; Hecht Stephen S
Improved method for determination of 1-hydroxypyrene in human urine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(7):1261-4.
2004: Zimmerman Cheryl L; Wu Zheng; Upadhyaya Pramod; Hecht Stephen S
Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Carcinogenesis 2004;25(7):1237-42.
2004: Jalas J R; Seetharaman M; Hecht S S; Murphy S E
Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(6):515-33.
2004: Hecht Stephen S; Carmella Steven G; Kenney Patrick M J; Low Siew-Hong; Arakawa Kazuko; Yu Mimi C
Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(6):997-1004.
2004: Hughes J R; Hecht S S; Carmella S G; Murphy S E; Callas P
Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni.
Tobacco control 2004;13(2):175-9.
2004: Hatsukami Dorothy K; Lemmonds Charlotte; Zhang Yan; Murphy Sharon E; Le Chap; Carmella Steven G; Hecht Stephen S
Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products.
Journal of the National Cancer Institute 2004;96(11):844-52.
2004: Hecht Stephen S; Carmella Steven G; Le Ky-Anh; Murphy Sharon E; Li Y Shelby; Le Chap; Jensen Joni; Hatsukami Dorothy K
Effects of reduced cigarette smoking on levels of 1-hydroxypyrene in urine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(5):834-42.
2004: Hecht Stephen S; Villalta Peter W; Sturla Shana J; Cheng Guang; Yu Nanxiong; Upadhyaya Pramod; Wang Mingyao
Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA.
Chemical research in toxicology 2004;17(5):588-97.
2004: Sexton Ken; Adgate John L; Church Timothy R; Hecht Stephen S; Ramachandran Gurumurthy; Greaves Ian A; Fredrickson Ann L; Ryan Andrew D; Carmella Steven G; Geisser Mindy S
Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences.
Environmental health perspectives 2004;112(3):392-7.
2004: Hecht S S
Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke.
Tobacco control 2004;13 Suppl 1():i48-56.
2004: Hecht Stephen S; Murphy Sharon E; Carmella Steven G; Zimmerman Cheryl L; Losey London; Kramarczuk Irene; Roe Mikel R; Puumala Susan S; Li Y Shelby; Le Chap; Jensen Joni; Hatsukami Dorothy K
Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.
Journal of the National Cancer Institute 2004;96(2):107-15.
2003: Anderson Kristin E; Kliris Jen; Murphy Lois; Carmella Steven G; Han Shaomei; Link Carrie; Bliss Robin L; Puumala Susan; Murphy Sharon E; Hecht Stephen S
Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(12):1544-6.
2003: Hecht Stephen S; Chen Menglan; Yagi Haruhiko; Jerina Donald M; Carmella Steven G
r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(12):1501-8.
2003: Carmella Steven G; Han Shaomei; Fristad Anne; Yang Yiying; Hecht Stephen S
Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(11 Pt 1):1257-61.
2003: Hecht Stephen S
Tobacco carcinogens, their biomarkers and tobacco-induced cancer.
Nature reviews. Cancer 2003;3(10):733-44.
2003: Wong Hansen L; Murphy Sharon E; Hecht Stephen S
Preferential metabolic activation of N-nitrosopiperidine as compared to its structural homologue N-nitrosopyrrolidine by rat nasal mucosal microsomes.
Chemical research in toxicology 2003;16(10):1298-305.
2003: Jalas John R; McIntee Edward J; Kenney Patrick M J; Upadhyaya Pramod; Peterson Lisa A; Hecht Stephen S
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Chemical research in toxicology 2003;16(6):794-806.
2003: Jalas John R; Hecht Stephen S
Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.
Chemical research in toxicology 2003;16(6):782-93.
2003: Hatsukami D K; Hecht S S; Hennrikus D J; Joseph A M; Pentel P R
Biomarkers of tobacco exposure or harm: application to clinical and epidemiological studies. 25-26 October 2001, Minneapolis, Minnesota.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2003;5(3):387-96.
2003: Wang Mingyao; Cheng Guang; Sturla Shana J; Shi Yongli; McIntee Edward J; Villalta Peter W; Upadhyaya Pramod; Hecht Stephen S
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens.
Chemical research in toxicology 2003;16(5):616-26.
2003: Hatsukami Dorothy K; Edmonds Amanda; Schulte Susan; Jensen Joni; Le Chap T; Losey London; Carmella Steven G; Hecht Stephen S
Preliminary study on reducing oral moist snuff use.
Drug and alcohol dependence 2003;70(2):215-20.
2003: Boysen Gunnar; Kenney Patrick M J; Upadhyaya Pramod; Wang Mingyao; Hecht Stephen S
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.
Carcinogenesis 2003;24(3):517-25.
2003: Upadhyaya Pramod; Sturla Shana J; Tretyakova Natalia; Ziegel Rebecca; Villalta Peter W; Wang Mingyao; Hecht Stephen S
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA.
Chemical research in toxicology 2003;16(2):180-90.
2003: Cheng Guang; Shi Yongli; Sturla Shana J; Jalas John R; McIntee Edward J; Villalta Peter W; Wang Mingyao; Hecht Stephen S
Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links.
Chemical research in toxicology 2003;16(2):145-52.
2003: Wong Hansen L; Murphy Sharon E; Wang Mingyao; Hecht Stephen S
Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3.
Carcinogenesis 2003;24(2):291-300.
2003: Boysen Gunnar; Hecht Stephen S
Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods.
Mutation research 2003;543(1):17-30.
2002: Hecht Stephen S; Kenney Patrick M J; Wang Mingyao; Upadhyaya Pramod
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.
Cancer letters 2002;187(1-2):87-94.
2002: Carmella Steven G; Chen Menglan; Villalta Peter W; Gurney James G; Hatsukami Dorothy K; Hecht Stephen S
Ethylation and methylation of hemoglobin in smokers and non-smokers.
Carcinogenesis 2002;23(11):1903-10.
2002: Pfeifer Gerd P; Denissenko Mikhail F; Olivier Magali; Tretyakova Natalia; Hecht Stephen S; Hainaut Pierre
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers.
Oncogene 2002;21(48):7435-51.
2002: Upadhyaya Pramod; Zimmerman Cheryl L; Hecht Stephen S
Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(10):1115-22.
2002: Hecht Stephen S; Upadhyaya Pramod; Wang Mingyao; Bliss Robin L; McIntee Edward J; Kenney Patrick M J
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.
Carcinogenesis 2002;23(9):1455-61.
2002: Sticha Kristina R K; Kenney Patrick M J; Boysen Gunnar; Liang Hong; Su Xiaojing; Wang Mingyao; Upadhyaya Pramod; Hecht Stephen S
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Carcinogenesis 2002;23(9):1433-9.
2002: Hecht Stephen S
Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention.
The lancet oncology 2002;3(8):461-9.
2002: Hecht Stephen S
Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer.
Carcinogenesis 2002;23(6):907-22.
2002: Stepanov Irina; Carmella Steven G; Hecht Stephen S; Duca Gheorghe
Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco.
Journal of agricultural and food chemistry 2002;50(10):2793-7.
2002: Carmella Steven G; Le Ka Ky-anh; Upadhyaya Pramod; Hecht Stephen S
Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.
Chemical research in toxicology 2002;15(4):545-50.
2002: Gurney James G; Chen Menglan; Skluzacek Maria C; Kasum Christine M; Carmella Steven G; Villalta Peter W; Hecht Stephen S
Null association between frequency of cured meat consumption and methylvaline and ethylvaline hemoglobin adduct levels: the N-nitroso brain cancer hypothesis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(4):421-2.
2002: Matthews Sara J; Hecht Stephen S; Picton Helen M; Ye Ming; Carmella Steven G; Shires Susan; Wild Christopher P; Hay Alastair W M
No association between smoking and the presence of tobacco-specific nitrosamine metabolites in ovarian follicular fluid.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(3):321-2.
2002: Wu Ming-Tsang; Simpson Christopher D; Christiani David C; Hecht Stephen S
Relationship of exposure to coke-oven emissions and urinary metabolites of benzo(a)pyrene and pyrene in coke-oven workers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(3):311-4.
2002: Hecht Stephen S; Carmella Steven G; Ye Ming; Le Ky-anh; Jensen Joni A; Zimmerman Cheryl L; Hatsukami Dorothy K
Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use.
Cancer research 2002;62(1):129-34.
2002: Wu Zheng; Upadhyaya Pramod; Carmella Steven G; Hecht Stephen S; Zimmerman Cheryl L
Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution.
Carcinogenesis 2002;23(1):171-9.
2002: Hecht Stephen S
Tobacco smoke carcinogens and breast cancer.
Environmental and molecular mutagenesis 2002;39(2-3):119-26.
2001: Hecht S S; Ye M; Carmella S G; Fredrickson A; Adgate J L; Greaves I A; Church T R; Ryan A D; Mongin S J; Sexton K
Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(11):1109-16.
2001: Wang M; McIntee E J; Shi Y; Cheng G; Upadhyaya P; Villalta P W; Hecht S S
Reactions of alpha-acetoxy-N-nitrosopyrrolidine with deoxyguanosine and DNA.
Chemical research in toxicology 2001;14(10):1435-45.
2001: Hecht S S; McIntee E J; Wang M
New DNA adducts of crotonaldehyde and acetaldehyde.
Toxicology 2001;166(1-2):31-6.
2001: Wang M; McIntee E J; Cheng G; Shi Y; Villalta P W; Hecht S S
Reactions of 2,6-dimethyl-1,3-dioxane-4-ol (aldoxane) with deoxyguanosine and DNA.
Chemical research in toxicology 2001;14(8):1025-32.
2001: Leslie E M; Ito K; Upadhyaya P; Hecht S S; Deeley R G; Cole S P
Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog.
The Journal of biological chemistry 2001;276(30):27846-54.
2001: Baum M; Amin S; Guengerich F P; Hecht S S; Köhl W; Eisenbrand G
Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung.
Chemical research in toxicology 2001;14(6):686-93.
2001: Murphy S E; Johnson L M; Losey L M; Carmella S G; Hecht S S
Consumption of watercress fails to alter coumarin metabolism in humans.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):786-8.
2001: Hecht S S; Kenney P M; Wang M; Upadhyaya P
Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo.
Cancer letters 2001;167(1):1-6.
2001: Upadhyaya P; McIntee E J; Hecht S S
Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines.
Chemical research in toxicology 2001;14(5):555-61.
2001: Liebes L; Conaway C C; Hochster H; Mendoza S; Hecht S S; Crowell J; Chung F L
High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate.
Analytical biochemistry 2001;291(2):279-89.
2001: Wang M; McIntee E J; Cheng G; Shi Y; Villalta P W; Hecht S S
A Schiff base is a major DNA adduct of crotonaldehyde.
Chemical research in toxicology 2001;14(4):423-30.
2001: Anderson K E; Carmella S G; Ye M; Bliss R L; Le C; Murphy L; Hecht S S
Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke.
Journal of the National Cancer Institute 2001;93(5):378-81.
2001: Hecht S S; McIntee E J; Cheng G; Shi Y; Villalta P W; Wang M
New aspects of DNA adduct formation by the carcinogens crotonaldehyde and acetaldehyde.
Advances in experimental medicine and biology 2001;500():63-71.
2001: Gurney J G; Smith M A; Olshan A F; Hecht S S; Kasum C M
Clues to the etiology of childhood brain cancer: N-nitroso compounds, polyomaviruses, and other factors of interest.
Cancer investigation 2001;19(6):630-40.
2001: Hecht S S
Carcinogen biomarkers for lung or oral cancer chemoprevention trials.
IARC scientific publications 2001;154():245-55.
2000: Hecht S S; Hoffmann D
Re: Cigar smoking in men and risk of death from tobacco-related cancers.
Journal of the National Cancer Institute 2000;92(24):2040.
2000: Wang M; McIntee E J; Cheng G; Shi Y; Villalta P W; Hecht S S
Identification of DNA adducts of acetaldehyde.
Chemical research in toxicology 2000;13(11):1149-57.
2000: Hecht S S; Hochalter J B; Villalta P W; Murphy S E
2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12493-7.
2000: Wang M; McIntee E J; Cheng G; Shi Y; Villalta P W; Hecht S S
Identification of paraldol-deoxyguanosine adducts in DNA reacted with crotonaldehyde.
Chemical research in toxicology 2000;13(10):1065-74.
2000: Sticha K R; Staretz M E; Wang M; Liang H; Kenney P M; Hecht S S
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Carcinogenesis 2000;21(9):1711-9.
2000: Hecht S S
Inhibition of carcinogenesis by isothiocyanates.
Drug metabolism reviews 2000;32(3-4):395-411.
2000: Upadhyaya P; Carmella S G; Guengerich F P; Hecht S S
Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues.
Carcinogenesis 2000;21(6):1233-8.
2000: Hecht S S
Metabolically activated carcinogens and mutations in the p53 tumor suppressor gene in lung cancer.
Journal of the National Cancer Institute 2000;92(10):782-3.
2000: Simpson C D; Wu M T; Christiani D C; Santella R M; Carmella S G; Hecht S S
Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry.
Chemical research in toxicology 2000;13(4):271-80.
2000: Carmella S G; McIntee E J; Chen M; Hecht S S
Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco.
Carcinogenesis 2000;21(4):839-43.
2000: Milunsky A; Carmella S G; Ye M; Hecht S S
A tobacco-specific carcinogen in the fetus.
Prenatal diagnosis 2000;20(4):307-10.
2000: Hecht S S; Kenney P M; Wang M; Trushin N; Upadhyaya P
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Cancer letters 2000;150(1):49-56.
2000: McIntee E J; Hecht S S
Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats.
Chemical research in toxicology 2000;13(3):192-9.
2000: Hecht S S; Trushin N; Chhabra S K; Anderson L M; Nerurkar P V
Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured monkey lung explants.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(1):5-9.
1999: Hecht S S; Carmella S G; Murphy S E
Effects of watercress consumption on urinary metabolites of nicotine in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(10):907-13.
1999: Hecht S S
Correspondence re: C. Chen et al., CYP2D6 genotype and the incidence of anal and vulvar cancer. Cancer Epidemiol. Biomark. Prev., 8: 317-321, 1999.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(9):839-40.
1999: Carmella S G; Ye M; Upadhyaya P; Hecht S S
Stereochemistry of metabolites of a tobacco-specific lung carcinogen in smokers' urine.
Cancer research 1999;59(15):3602-5.
1999: Upadhyaya P; Kenney P M; Hochalter J B; Wang M; Hecht S S
Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.
Carcinogenesis 1999;20(8):1577-82.
1999: Hecht S S
Tobacco smoke carcinogens and lung cancer.
Journal of the National Cancer Institute 1999;91(14):1194-210.
1999: Hecht S S; Kenney P M; Wang M; Trushin N; Agarwal S; Rao A V; Upadhyaya P
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Cancer letters 1999;137(2):123-30.
1999: Lin J M; Desai D; Chung L; Hecht S S; Amin S
Synthesis of anti-7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydro-11-methylbenzo[a]pyrene and its reaction with DNA.
Chemical research in toxicology 1999;12(4):341-6.
1999: Hecht S S
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
The Journal of nutrition 1999;129(3):768S-774S.
1999: Lackmann G M; Salzberger U; Töllner U; Chen M; Carmella S G; Hecht S S
Metabolites of a tobacco-specific carcinogen in urine from newborns.
Journal of the National Cancer Institute 1999;91(5):459-65.
1999: Hecht S S
DNA adduct formation from tobacco-specific N-nitrosamines.
Mutation research 1999;424(1-2):127-42.
1999: Hecht S S; Hatsukami D K; Bonilla L E; Hochalter J B
Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism.
Chemical research in toxicology 1999;12(2):172-9.
1999: Trushin N; Hecht S S
Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.
Chemical research in toxicology 1999;12(2):164-71.
1999: Hecht S S; Carmella S G; Chen M; Dor Koch J F; Miller A T; Murphy S E; Jensen J A; Zimmerman C L; Hatsukami D K
Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation.
Cancer research 1999;59(3):590-6.
1999: Jyonouchi H; Sun S; Iijima K; Wang M; Hecht S S
Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol.
Carcinogenesis 1999;20(1):139-45.
1999: Hecht S S; Upadhyaya P; Wang M
Reactions of alpha-acetoxy-N-nitrosopyrrolidine and crotonaldehyde with DNA.
IARC scientific publications 1999;(150):147-54.
1998: Stoner G D; Adams C; Kresty L A; Amin S G; Desai D; Hecht S S; Murphy S E; Morse M A
Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate.
Carcinogenesis 1998;19(12):2139-43.
1998: Wang M; Upadhyaya P; Dinh T T; Bonilla L E; Hecht S S
Lactols in hydrolysates of DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or crotonaldehyde.
Chemical research in toxicology 1998;11(12):1567-73.
1998: Huang C; Ma W Y; Li J; Hecht S S; Dong Z
Essential role of p53 in phenethyl isothiocyanate-induced apoptosis.
Cancer research 1998;58(18):4102-6.
1998: Hecht S S; Hoffman D
N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(3):244-6.
1998: Hecht S S
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.
Chemical research in toxicology 1998;11(6):559-603.
1998: Hecht S S; Hoffmann D
N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(2):165-6.
1998: Parsons W D; Carmella S G; Akerkar S; Bonilla L E; Hecht S S
A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(3):257-60.
1998: Hecht S S; Ronai Z A; Dolan L; Desai D; Amin S
Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene.
Carcinogenesis 1998;19(1):157-60.
1997: Hecht S S
Tobacco and cancer: approaches using carcinogen biomarkers and chemoprevention.
Annals of the New York Academy of Sciences 1997;833():91-111.
1997: Cinciripini P M; Hecht S S; Henningfield J E; Manley M W; Kramer B S
Tobacco addiction: implications for treatment and cancer prevention.
Journal of the National Cancer Institute 1997;89(24):1852-67.
1997: Hecht S S
Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1997;216(2):181-91.
1997: Melikian A A; Sun P; Pierpont C; Coleman S; Hecht S S
Gas chromatographic-mass spectrometric determination of benzo[a]pyrene and chrysene diol epoxide globin adducts in humans.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(10):833-9.
1997: Richie J P; Carmella S G; Muscat J E; Scott D G; Akerkar S A; Hecht S S
Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(10):783-90.
1997: Hecht S S; Spratt T E; Trushin N
Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Carcinogenesis 1997;18(9):1851-4.
1997: Staretz M E; Koenig L A; Hecht S S
Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.
Carcinogenesis 1997;18(9):1715-22.
1997: Chen L J; Hecht S S; Peterson L A
Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan.
Chemical research in toxicology 1997;10(8):866-74.
1997: Wang M; Hecht S S
A cyclic N7,C-8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats.
Chemical research in toxicology 1997;10(7):772-8.
1997: Taioli E; Garbers S; Bradlow H L; Carmella S G; Akerkar S; Hecht S S
Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(7):517-22.
1997: Gurney J G; Pogoda J M; Holly E A; Hecht S S; Preston-Martin S
Aspartame consumption in relation to childhood brain tumor risk: results from a case-control study.
Journal of the National Cancer Institute 1997;89(14):1072-4.
1997: Huang C; Ma W Y; Hecht S S; Dong Z
Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase.
Cancer research 1997;57(14):2873-8.
1997: Hecht S S
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke.
Environmental health perspectives 1997;105 Suppl 4():955-63.
1997: Wang L; Spratt T E; Liu X K; Hecht S S; Pegg A E; Peterson L A
Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.
Chemical research in toxicology 1997;10(5):562-7.
1997: Carmella S G; Borukhova A; Desai D; Hecht S S
Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite.
Carcinogenesis 1997;18(3):587-92.
1997: Carmella S G; Borukhova A; Akerkar S A; Hecht S S
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(2):113-20.
1997: Staretz M E; Murphy S E; Patten C J; Nunes M G; Koehl W; Amin S; Koenig L A; Guengerich F P; Hecht S S
Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(2):154-62.
1997: Staretz M E; Foiles P G; Miglietta L M; Hecht S S
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.
Cancer research 1997;57(2):259-66.
1996: Hecht S S; Rivenson A; Amin S; Krzeminski J; el-Bayoumy K; Reddy B S; Kurtzke C; La Voie E J
Mammary carcinogenicity of diol epoxide metabolites of benzo[j]fluoranthene in female CD rats.
Cancer letters 1996;106(2):251-5.
1996: Hecht S S; Trushin N; Rigotty J; Carmella S G; Borukhova A; Akerkar S; Desai D; Amin S; Rivenson A
Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats.
Carcinogenesis 1996;17(9):2061-7.
1996: Hecht S S; Trushin N; Rigotty J; Carmella S G; Borukhova A; Akerkar S; Rivenson A
Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996;5(8):645-52.
1996: Kresty L A; Carmella S G; Borukhova A; Akerkar S A; Gopalakrishnan R; Harris R E; Stoner G D; Hecht S S
Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996;5(7):521-5.
1996: Ronai Z; Polotskaya A; Gradia S; Amin S; Hecht S S
Expression of a 32 kDa protein in rat mammary tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide.
International journal of cancer. Journal international du cancer 1996;67(1):124-8.
1996: Shimada T; Hayes C L; Yamazaki H; Amin S; Hecht S S; Guengerich F P; Sutter T R
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
Cancer research 1996;56(13):2979-84.
1996: Liu Z; Young-Sciame R; Hecht S S
Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.
Chemical research in toxicology 1996;9(4):774-80.
1996: Canella K A; Diwan B A; Gorelick P L; Donovan P J; Sipowicz M A; Kasprzak K S; Weghorst C M; Snyderwine E G; Davis C D; Keefer L K; Kyrtopoulos S A; Hecht S S; Wang M; Anderson L M; Rice J M
Liver tumorigenesis by Helicobacter hepaticus: considerations of mechanism.
In vivo (Athens, Greece) 1996;10(3):285-92.
1996: el-Bayoumy K; Ji B Y; Upadhyaya P; Chae Y H; Kurtzke C; Rivenson A; Reddy B S; Amin S; Hecht S S
Lack of tumorigenicity of cholesterol epoxides and estrone-3,4-quinone in the rat mammary gland.
Cancer research 1996;56(9):1970-3.
1996: Melikian A A; Sun P; Coleman S; Amin S; Hecht S S
Detection of DNA and globin adducts of polynuclear aromatic hydrocarbon diol epoxides by gas chromatography-mass spectrometry and -3H-CH3I postlabeling of released tetraols.
Chemical research in toxicology 1996;9(2):508-16.
1996: Chen W; Weisburger J H; Fiala E S; Spratt T E; Carmella S G; Chen D; Hecht S S
Gastric carcinogenesis: 2-chloro-4-methylthiobutanoic acid, a novel mutagen in salted, pickled Sanma hiraki fish, or similarly treated methionine.
Chemical research in toxicology 1996;9(1):58-66.
1996: Hecht S S
Carcinogen-derived biomarkers and lung cancer.
Preventive medicine 1996;25(1):7-9.
1996: Koehl W; Amin S; Staretz M E; Ueng Y F; Yamazaki H; Tateishi T; Guengerich F P; Hecht S S
Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.
Cancer research 1996;56(2):316-24.
1996: Hecht S S
Chemoprevention of lung cancer by isothiocyanates.
Advances in experimental medicine and biology 1996;401():1-11.
1996: Hoffmann D; Rivenson A; Hecht S S
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung.
Critical reviews in toxicology 1996;26(2):199-211.
1996: Hecht S S
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen.
Critical reviews in toxicology 1996;26(2):163-81.
1996: Amin S; Desai D; Hecht S S; Hoffmann D
Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays.
Critical reviews in toxicology 1996;26(2):139-47.
1995: Hecht S S; Chung F L; Richie J P; Akerkar S A; Borukhova A; Skowronski L; Carmella S G
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995;4(8):877-84.
1995: Staretz M E; Hecht S S
Effects of phenethyl isothiocyanate on the tissue distribution of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and metabolites in F344 rats.
Cancer research 1995;55(23):5580-8.
1995: Amin S; Desai D; Dai W; Harvey R G; Hecht S S
Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene.
Carcinogenesis 1995;16(11):2813-7.
1995: Chen L J; Hecht S S; Peterson L A
Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan.
Chemical research in toxicology 1995;8(7):903-6.
1995: Carmella S G; Akerkar S A; Richie J P; Hecht S S
Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995;4(6):635-42.
1995: Amin S; Krzeminski J; Rivenson A; Kurtzke C; Hecht S S; el-Bayoumy K
Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis 1995;16(8):1971-4.
1995: Hecht S S; Amin S; Lin J M; Rivenson A; Kurtzke C; el-Bayoumy K
Mammary carcinogenicity in female CD rats of a diol epoxide metabolite of fluoranthene, a commonly occurring environmental pollutant.
Carcinogenesis 1995;16(6):1433-5.
1995: Wang M; Young-Sciame R; Chung F L; Hecht S S
Formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts in the reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with DNA.
Chemical research in toxicology 1995;8(4):617-24.
1995: Young-Sciame R; Wang M; Chung F L; Hecht S S
Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts.
Chemical research in toxicology 1995;8(4):607-16.
1995: Chen W; Weisburger J H; Fiala E S; Carmella S G; Chen D; Spratt T E; Hecht S S
Unexpected mutagen in fish.
Nature 1995;374(6523):599.
1995: el-Bayoumy K; Chae Y H; Upadhyaya P; Rivenson A; Kurtzke C; Reddy B; Hecht S S
Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats.
Carcinogenesis 1995;16(2):431-4.
1995: Page J E; Szeliga J; Amin S; Hecht S S; Dipple A
Mutational spectra for 5,6-dimethylchrysene 1,2-dihydrodiol 3,4-epoxides in the supF gene of pSP189.
Chemical research in toxicology 1995;8(1):143-7.
1995: Hecht S S
Chemoprevention by isothiocyanates.
Journal of cellular biochemistry. Supplement 1995;22():195-209.
1994: Hecht S S; Isaacs S; Trushin N
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
Carcinogenesis 1994;15(12):2721-5.
1994: Ronai Z A; Gradia S; el-Bayoumy K; Amin S; Hecht S S
Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide.
Carcinogenesis 1994;15(10):2113-6.
1994: el-Bayoumy K; Johnson B; Roy A K; Upadhyaya P; Partian S; Hecht S S
Development of methods to monitor exposure to 1-nitropyrene.
Environmental health perspectives 1994;102 Suppl 6():31-7.
1994: Hecht S S
Environmental tobacco smoke and lung cancer: the emerging role of carcinogen biomarkers and molecular epidemiology.
Journal of the National Cancer Institute 1994;86(18):1369-70.
1994: Peterson L A; Ng D K; Stearns R A; Hecht S S
Formation of NADP(H) analogs of tobacco-specific nitrosamines in rat liver and pancreatic microsomes.
Chemical research in toxicology 1994;7(5):599-608.
1994: Hecht S S; Carmella S G; Foiles P G; Murphy S E
Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosamines.
Cancer research 1994;54(7 Suppl):1912s-1917s.
1994: Krzeminski J; Lin J M; Amin S; Hecht S S
Synthesis of Fjord region diol epoxides as potential ultimate carcinogens of dibenzo[a,l]pyrene.
Chemical research in toxicology 1994;7(2):125-9.
1994: Trushin N; Rivenson A; Hecht S S
Evidence supporting the role of DNA pyridyloxobutylation in rat nasal carcinogenesis by tobacco-specific nitrosamines.
Cancer research 1994;54(5):1205-11.
1994: el-Bayoumy K; Johnson B; Partian S; Upadhyaya P; Hecht S S
In vivo binding of 1-nitropyrene to albumin in the rat.
Carcinogenesis 1994;15(1):119-23.
1994: Hecht S S; el-Bayoumy K; Rivenson A; Amin S
Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene.
Cancer research 1994;54(1):21-4.
1994: Hecht S S
Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies.
Drug metabolism reviews 1994;26(1-2):373-90.
1994: Hecht S S; Carmella S G; Murphy S E
Tobacco-specific nitrosamine-hemoglobin adducts.
Methods in enzymology 1994;231():657-67.
1994: Hecht S S; Peterson L A; Spratt T E
Tobacco-specific nitrosamines.
IARC scientific publications 1994;(125):91-106.
1993: Hecht S S; Carmella S G; Murphy S E; Akerkar S; Brunnemann K D; Hoffmann D
A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke.
The New England journal of medicine 1993;329(21):1543-6.
1993: Lin J M; Amin S; Trushin N; Hecht S S
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Cancer letters 1993;74(3):151-9.
1993: Desai D; Kagan S S; Amin S; Carmella S G; Hecht S S
Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents.
Chemical research in toxicology 1993;6(6):794-9.
1993: Ronai Z A; Gradia S; Peterson L A; Hecht S S
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.
Carcinogenesis 1993;14(11):2419-22.
1993: Amin S; Desai D; Hecht S S
Tumor-initiating activity on mouse skin of bay region diol-epoxides of 5,6-dimethylchrysene and benzo[c]phenanthrene.
Carcinogenesis 1993;14(10):2033-7.
1993: Balasta L; Xu R; Geacintov N E; Swenberg C E; Amin S; Hecht S S
Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities.
Chemical research in toxicology 1993;6(5):616-24.
1993: Alworth W L; Young-Sciame R; Hecht S S
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450.
Carcinogenesis 1993;14(8):1711-3.
1993: el-Bayoumy K; Rivenson A; Upadhyaya P; Chae Y H; Hecht S S
Induction of mammary cancer by 6-nitrochrysene in female CD rats.
Cancer research 1993;53(16):3719-22.
1993: Swenson D H; el-Bayoumy K; Shuie G H; Hecht S S; Fiala E; Kadlubar F F; Freeman J P
Synthesis of N-(purin-8-yl)arylamines.
Chemical research in toxicology 1993;6(4):480-5.
1993: el-Bayoumy K; Upadhyaya P; Desai D H; Amin S; Hecht S S
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
Carcinogenesis 1993;14(6):1111-3.
1993: Peterson L A; Liu X K; Hecht S S
Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
Cancer research 1993;53(12):2780-5.
1993: Shillitoe E J; Schantz S P; Spitz M R; Hecht S S
Environmental carcinogenesis and its prevention: the head and neck cancer model.
Cancer research 1993;53(9):2189-91.
1993: Hecht S S; Carmella S G; Foiles P G; Murphy S E; Peterson L A
Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans.
Environmental health perspectives 1993;99():57-63.
1993: Carmella S G; Kagan S S; Hecht S S
Evidence that a hemoglobin adduct used for dosimetry of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a carboxylic ester.
Environmental health perspectives 1993;99():203-5.
1993: Hecht S S; Trushin N; Reid-Quinn C A; Burak E S; Jones A B; Southers J L; Gombar C T; Carmella S G; Anderson L M; Rice J M
Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites.
Carcinogenesis 1993;14(2):229-36.
1993: Carmella S G; Akerkar S; Hecht S S
Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine.
Cancer research 1993;53(4):721-4.
1993: Hecht S S; Carmella S G; Murphy S E; Foiles P G; Chung F L
Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer.
Journal of cellular biochemistry. Supplement 1993;17F():27-35.
1992: Lasker S E; Iatropoulos M J; Hecht S S; Misra B; Amin S; Zang E; Williams G M
N-ethyl-N-nitrosourea induced brain tumors in rats monitored by nuclear magnetic resonance imaging, plasma proton nuclear magnetic resonance spectroscopy and microscopy.
Cancer letters 1992;67(2-3):125-31.
1992: el-Bayoumy K; Desai D; Upadhyaya P; Amin S; Hecht S S
Comparative tumorigenicity of nitrochrysene isomers in newborn mice.
Carcinogenesis 1992;13(12):2271-5.
1992: Misra B; Lin J M; Amin S; Hecht S S
Distinct conformers of alkylchrysene diol epoxide-deoxyguanosine adducts detected by proton NMR.
Chemical research in toxicology 1992;5(6):756-9.
1992: Wang M; Chung F L; Hecht S S
Formation of 7-(4-oxobutyl)guanine in hepatic DNA of rats treated with N-nitrosopyrrolidine.
Carcinogenesis 1992;13(10):1909-11.
1992: Hecht S S; Young-Sciame R; Chung F L
Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct.
Chemical research in toxicology 1992;5(5):706-12.
1992: Lin J M; Desai D H; Morse M A; Amin S; Hecht S S
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol.
Chemical research in toxicology 1992;5(5):674-9.
1992: Foiles P G; Murphy S E; Peterson L A; Carmella S G; Hecht S S
DNA and hemoglobin adducts as markers of metabolic activation of tobacco-specific carcinogens.
Cancer research 1992;52(9 Suppl):2698s-2701s.
1992: Misra B; Amin S; Hecht S S
Dimethylchrysene diol epoxides: mutagenicity in Salmonella typhimurium, tumorigenicity in newborn mice, and reactivity with deoxyadenosine in DNA.
Chemical research in toxicology 1992;5(2):248-54.
1992: Misra B; Amin S; Hecht S S
Metabolism and DNA binding of 5,6-dimethylchrysene in mouse skin.
Chemical research in toxicology 1992;5(2):242-7.
1992: Amin S; Desai D; Hecht S S
Comparative tumorigenicity of dimethylchrysenes in mouse skin.
Chemical research in toxicology 1992;5(2):237-41.
1992: Carmella S G; Kagan S S; Hecht S S
Evidence that a hemoglobin adduct of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a 4-(3-pyridyl)-4-oxobutyl carboxylic acid ester.
Chemical research in toxicology 1992;5(1):76-80.
1991: Peterson L A; Mathew R; B1P6Murphy S E; Trushin N; Hecht S S
In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Carcinogenesis 1991;12(11):2069-72.
1991: Peterson L A; Hecht S S
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Cancer research 1991;51(20):5557-64.
1991: Peterson L A; Mathew R; Hecht S S
Quantitation of microsomal alpha-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Cancer research 1991;51(20):5495-500.
1991: Melikian A A; Prahalad K A; Amin S; Hecht S S
Comparative DNA binding of polynuclear aromatic hydrocarbons and their dihydrodiol and bay region diolepoxide metabolites in newborn mouse lung and liver.
Carcinogenesis 1991;12(9):1665-70.
1991: Anderson L M; Hecht S S; Kovatch R M; Amin S; Hoffmann D; Rice J M
Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice.
Cancer letters 1991;58(3):177-81.
1991: Amin S; Misra B; Braley J; Hecht S S
Comparative tumorigenicity in newborn mice of chrysene- and 5-alkylchrysene-1,2-diol-3,4-epoxides.
Cancer letters 1991;58(1-2):115-8.
1991: Doerr-O'Rourke K; Trushin N; Hecht S S; Stoner G D
Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue.
Carcinogenesis 1991;12(6):1029-34.
1991: Hecht S S; Carmella S G; Murphy S E
Hemoglobin adducts as biomarkers of exposure to and metabolic activation of carcinogenic tobacco-specific nitrosamines.
Biomedical and environmental sciences : BES 1991;4(1-2):93-103.
1991: Foiles P G; Akerkar S A; Carmella S G; Kagan M; Stoner G D; Resau J H; Hecht S S
Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers.
Chemical research in toxicology 1991;4(3):364-8.
1991: Morse M A; Eklind K I; Hecht S S; Jordan K G; Choi C I; Desai D H; Amin S G; Chung F L
Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice.
Cancer research 1991;51(7):1846-50.
1991: Hecht S S; Morse M A; Eklind K I; Chung F L
A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates.
Experimental lung research 1991;17(2):501-11.
1991: Hoffmann D; Rivenson A; Chung F L; Hecht S S
Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis.
Critical reviews in toxicology 1991;21(4):305-11.
1991: Rivenson A; Hecht S S; Hoffmann D
Carcinogenicity of tobacco-specific N-nitrosamines (TSNA): the role of the vascular network in the selection of target organs.
Critical reviews in toxicology 1991;21(4):255-64.
1991: Hecht S S; Hoffmann D
N-nitroso compounds and tobacco-induced cancers in man.
IARC scientific publications 1991;(105):54-61.
1991: Morse M A; Eklind K I; Hecht S S; Chung F L
Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates.
IARC scientific publications 1991;(105):529-34.
1991: Hecht S S; Kagan S S; Kagan M; Carmella S G
Quantification of 4-hydroxy-1-(3-pyridyl)-1-butanone released from human haemoglobin as a dosimeter for exposure to tobacco-specific nitrosamines.
IARC scientific publications 1991;(105):113-8.
1990: Murphy S E; Palomino A; Hecht S S; Hoffmann D
Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
Cancer research 1990;50(17):5446-52.
1990: Carmella S G; Kagan S S; Kagan M; Foiles P G; Palladino G; Quart A M; Quart E; Hecht S S
Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers, and nonsmokers.
Cancer research 1990;50(17):5438-45.
1990: Carmella S G; Kagan S S; Spratt T E; Hecht S S
Evaluation of cysteine adduct formation in rat hemoglobin by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and related compounds.
Cancer research 1990;50(17):5453-9.
1990: Peterson L A; Carmella S G; Hecht S S
Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Carcinogenesis 1990;11(8):1329-33.
1990: Spratt T E; Peterson L A; Confer W L; Hecht S S
Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles.
Chemical research in toxicology 1990;3(4):350-6.
1990: Geacintov N E; Lee M S; Ibanez V; Amin S; Hecht S S
Differences in conformations of covalent adducts derived from the binding of 5- and 6-methylchrysene diol epoxide stereoisomers to DNA.
Carcinogenesis 1990;11(6):985-9.
1990: Hecht S S; Jordan K G; Choi C I; Trushin N
Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
Carcinogenesis 1990;11(6):1017-20.
1990: Amin S; Hecht S S; Di Raddo P; Harvey R G
Comparative tumor initiating activities of cyclopentano and methyl derivatives of 5-methylchrysene and chrysene.
Cancer letters 1990;51(1):17-20.
1990: Morse M A; Reinhardt J C; Amin S G; Hecht S S; Stoner G D; Chung F L
Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice.
Cancer letters 1990;49(3):225-30.
1990: Melikian A A; Goldin B F; Prahalad A K; Hecht S S
Modulation of benzo[a]pyrene-DNA adducts in hamster cheek pouch by chronic ethanol consumption.
Chemical research in toxicology 1990;3(2):139-43.
1990: Morse M A; Hecht S S; Chung F L
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Basic life sciences 1990;52():345-50.
1989: Belinsky S A; White C M; Trushin N; Hecht S S
Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the Fischer rat.
Carcinogenesis 1989;10(12):2269-74.
1989: Wang M; Chung F L; Hecht S S
Formation of acyclic and cyclic guanine adducts in DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine.
Chemical research in toxicology 1989;2(6):423-8.
1989: Hecht S S; Morse M A; Amin S; Stoner G D; Jordan K G; Choi C I; Chung F L
Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet.
Carcinogenesis 1989;10(10):1901-4.
1989: Amin S; Misra B; Desai D; Huie K; Hecht S S
Chromatographic conditions for separation of 32P-labeled phosphates of major polynuclear aromatic hydrocarbon--deoxyribonucleoside adducts.
Carcinogenesis 1989;10(10):1971-4.
1989: Melikian A A; Jordan K G; Braley J; Rigotty J; Meschter C L; Hecht S S; Hoffmann D
Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes.
Carcinogenesis 1989;10(10):1897-900.
1989: Morse M A; Eklind K I; Amin S G; Hecht S S; Chung F L
Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates.
Carcinogenesis 1989;10(9):1757-9.
1989: el-Bayoumy K; Shiue G H; Amin S; Hecht S S
The effects of bay-region methyl substitution on 6-nitrochrysene mutagenicity in Salmonella typhimurium and tumorigenicity in newborn mice.
Carcinogenesis 1989;10(9):1685-9.
1989: Hecht S S; Lijinsky W; Kovatch R M; Chung F L; Saavedra J E
Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats.
Carcinogenesis 1989;10(8):1475-7.
1989: Foiles P G; Miglietta L M; Quart A M; Quart E; Kabat G C; Hecht S S
Evaluation of 32P-postlabeling analysis of DNA from exfoliated oral mucosa cells as a means of monitoring exposure of the oral cavity to genotoxic agents.
Carcinogenesis 1989;10(8):1429-34.
1989: Chung F L; Young R; Hecht S S
Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde.
Carcinogenesis 1989;10(7):1291-7.
1989: Anderson L M; Hecht S S; Dixon D E; Dove L F; Kovatch R M; Amin S; Hoffmann D; Rice J M
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
Cancer research 1989;49(14):3770-5.
1989: Delclos K B; el-Bayoumy K; Casciano D A; Walker R P; Kadlubar F F; Hecht S S; Shivapurkar N; Mandal S; Stoner G D
Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes.
Cancer research 1989;49(11):2909-13.
1989: Morse M A; Amin S G; Hecht S S; Chung F L
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Cancer research 1989;49(11):2894-7.
1989: el-Bayoumy K; Delclos K B; Heflich R H; Walker R; Shiue G H; Hecht S S
Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium.
Mutagenesis 1989;4(3):235-40.
1989: Spratt T E; Trushin N; Lin D; Hecht S S
Analysis for N2-(pyridyloxobutyl)deoxyguanosine adducts in DNA of tissues exposed to tritium-labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.
Chemical research in toxicology 1989;2(3):169-73.
1989: Chung F L; Wang M Y; Hecht S S
Detection of exocyclic guanine adducts in hydrolysates of hepatic DNA of rats treated with N-nitrosopyrrolidine and in calf thymus DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine.
Cancer research 1989;49(8):2034-41.
1989: Hecht S S; Mirvish S S; Gold B; Nagel D; Magee P N
Conference on advances in the biology and chemistry of N-nitroso and related compounds.
Cancer research 1989;49(5):1327-9.
1989: el-Bayoumy K; Shiue G H; Hecht S S
Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice.
Carcinogenesis 1989;10(2):369-72.
1989: Morse M A; Wang C X; Stoner G D; Mandal S; Conran P B; Amin S G; Hecht S S; Chung F L
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.
Cancer research 1989;49(3):549-53.
1989: Roy A K; el-Bayoumy K; Hecht S S
32P-postlabeling analysis of 1-nitropyrene-DNA adducts in female Sprague-Dawley rats.
Carcinogenesis 1989;10(1):195-8.
1989: Melikian A A; Hecht S S; Hoffmann D
Mechanistic studies of tobacco carcinogenesis in mouse epidermis and lung tissues.
Progress in clinical and biological research 1989;298():331-45.
1989: Hecht S S; Hoffmann D
The relevance of tobacco-specific nitrosamines to human cancer.
Cancer surveys 1989;8(2):273-94.
1989: Weyand E H; Amin S; Huie K; Boger E; Neuber E; Hecht S S; LaVoie E J
Effects of fluorine substitution on the DNA binding and tumorigenicity of benzo[b]fluoranthene in mouse epidermis.
Chemico-biological interactions 1989;71(2-3):279-90.
1989: Melikian A A; Bagheri K; Hecht S S; Hoffmann D
Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice.
Chemico-biological interactions 1989;69(2-3):245-57.
1988: Amin S; Huie K; Balanikas G; Hecht S S
Synthesis and mutagenicity of 5-alkyl-substituted chrysene-1,2-diol-3,4-epoxides.
Carcinogenesis 1988;9(12):2305-8.
1988: Rivenson A; Hoffmann D; Prokopczyk B; Amin S; Hecht S S
Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.
Cancer research 1988;48(23):6912-7.
1988: Amin S; Balanikas G; Huie K; Hecht S S
Synthesis and tumor-initiating activities of dimethylchrysenes.
Chemical research in toxicology 1988;1(6):349-55.
1988: Morse M A; Wang C X; Amin S G; Hecht S S; Chung F L
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.
Carcinogenesis 1988;9(10):1891-5.
1988: Delclos K B; el-Bayoumy K; Hecht S S; Walker R P; Kadlubar F F
Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite.
Carcinogenesis 1988;9(10):1875-84.
1988: Hecht S S; Trushin N
DNA and hemoglobin alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.
Carcinogenesis 1988;9(9):1665-8.
1988: Hecht S S; Abbaspour A; Hoffman D
A study of tobacco carcinogenesis. XLII. Bioassay in A/J mice of some structural analogues of tobacco-specific nitrosamines.
Cancer letters 1988;42(1-2):141-5.
1988: el-Bayoumy K; Rivenson A; Johnson B; DiBello J; Little P; Hecht S S
Comparative tumorigenicity of 1-nitropyrene, 1-nitrosopyrene, and 1-aminopyrene administered by gavage to Sprague-Dawley rats.
Cancer research 1988;48(15):4256-60.
1988: Foiles P G; Miglietta L M; Akerkar S A; Everson R B; Hecht S S
Detection of O6-methyldeoxyguanosine in human placental DNA.
Cancer research 1988;48(15):4184-8.
1988: el-Bayoumy K; Shiue G H; Hecht S S
Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice.
Chemical research in toxicology 1988;1(4):243-7.
1988: Hecht S S; Hoffmann D
Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke.
Carcinogenesis 1988;9(6):875-84.
1988: Melikian A A; Amin S; Huie K; Hecht S S; Harvey R G
Reactivity with DNA bases and mutagenicity toward Salmonella typhimurium of methylchrysene diol epoxide enantiomers.
Cancer research 1988;48(7):1781-7.
1988: Roy A K; el-Bayoumy K; Hecht S S
Metabolism of K-region derivatives of 1-nitropyrene by rat liver in vitro.
Carcinogenesis 1988;9(2):255-8.
1988: Hecht S S; Spratt T E; Trushin N
Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.
Carcinogenesis 1988;9(1):161-5.
1988: Wang M Y; Chung F L; Hecht S S
Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine.
Chemical research in toxicology 1988;1(1):28-31.
1988: Hecht S S; Carmella S G; Trushin N; Spratt T E; Foiles P G; Hoffmann D
Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA.
IARC scientific publications 1988;(89):121-8.
1987: Domellöf L; Andersson M; Tjälve H; Veals S; Trushin N; Hecht S S
Distribution and metabolism of N'-nitrosonornicotine in the miniature pig.
Carcinogenesis 1987;8(11):1741-7.
1987: Geddie J E; Amin S; Huie K; Hecht S S
Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis.
Carcinogenesis 1987;8(11):1579-84.
1987: Hecht S S; Amin S; Huie K; Melikian A A; Harvey R G
Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis.
Cancer research 1987;47(20):5310-5.
1987: Melikian A A; Bagheri K; Hecht S S
Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.
Cancer research 1987;47(20):5354-60.
1987: Shiue G H; el-Bayoumy K; Hecht S S
Comparative metabolism and DNA binding of 6-nitro-5-methylchrysene and 5-methylchrysene.
Carcinogenesis 1987;8(9):1327-31.
1987: Amin S; Huie K; Balanikas G; Hecht S S; Pataki J; Harvey R G
High stereoselectivity in mouse skin metabolic activation of methylchrysenes to tumorigenic dihydrodiols.
Cancer research 1987;47(14):3613-7.
1987: Carmella S G; Hecht S S
Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.
Cancer research 1987;47(10):2626-30.
1987: Hecht S S; Lin D; Castonguay A; Rivenson A
Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
Carcinogenesis 1987;8(2):291-4.
1987: Foiles P G; Chung F L; Hecht S S
Development of a monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde.
Cancer research 1987;47(2):360-3.
1987: Brunnemann K D; Rivenson A; Adams J D; Hecht S S; Hoffmann D
A study of snuff carcinogenesis.
IARC scientific publications 1987;(84):456-9.
1987: Hecht S S; Carmella S G; Trushin N; Foiles P G; Lin D; Rubin J M; Chung F L
Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines.
IARC scientific publications 1987;(84):423-9.
1986: Amin S; Huie K; Hecht S S; Harvey R G
Synthesis of 6-methylchrysene-1,2-diol-3,4-epoxides and comparison of their mutagenicity to 5-methylchrysene-1,2-diol-3,4-epoxides.
Carcinogenesis 1986;7(12):2067-70.
1986: el-Bayoumy K; Donahue J M; Hecht S S; Hoffmann D
Identification and quantitative determination of aniline and toluidines in human urine.
Cancer research 1986;46(12 Pt 1):6064-7.
1986: McCoy G D; Hecht S S; Furuya K
The effect of chronic ethanol consumption on the tumorigenicity of N-nitrosopyrrolidine in male Syrian golden hamsters.
Cancer letters 1986;33(2):151-9.
1986: el-Bayoumy K; Villucci P; Roy A K; Hecht S S
Synthesis of K-region derivatives of the carcinogen 1-nitropyrene.
Carcinogenesis 1986;7(9):1577-80.
1986: Hecht S S; Rivenson A; Braley J; DiBello J; Adams J D; Hoffmann D
Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff.
Cancer research 1986;46(8):4162-6.
1986: Hecht S S; Lin D
Comparative mutagenicity of 4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal and 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, model compounds for alpha-hydroxylation of N'-nitrosonornicotine.
Carcinogenesis 1986;7(4):611-4.
1986: Connolly G N; Winn D M; Hecht S S; Henningfield J E; Walker B; Hoffmann D
The reemergence of smokeless tobacco.
The New England journal of medicine 1986;314(16):1020-7.
1986: el-Bayoumy K; Hecht S S
Mutagenicity of K-region derivatives of 1-nitropyrene; remarkable activity of 1- and 3-nitro-5H-phenanthro[4,5-bcd]pyran-5-one.
Mutation research 1986;170(1-2):31-40.
1986: el-Bayoumy K; Amin S; Hecht S S
Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism.
Carcinogenesis 1986;7(4):673-6.
1986: Chung F L; Tanaka T; Hecht S S
Induction of liver tumors in F344 rats by crotonaldehyde.
Cancer research 1986;46(3):1285-9.
1986: Hecht S S; Trushin N; Castonguay A; Rivenson A
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Cancer research 1986;46(2):498-502.
1986: Chung F L; Wang M; Carmella S G; Hecht S S
Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice.
Cancer research 1986;46(1):165-8.
1986: Murphy S E; Hecht S S
Effects of chronic ethanol consumption on benzo(a)pyrene metabolism and glutathione S-transferase activities in Syrian golden hamster cheek pouch and liver.
Cancer research 1986;46(1):141-6.
1986: Melikian A A; Leszczynska J M; Hecht S S; Hoffmann D
Effects of the co-carcinogen catechol on benzo[a]pyrene metabolism and DNA adduct formation in mouse skin.
Carcinogenesis 1986;7(1):9-15.
1986: Chung F L; Hecht S S; Palladino G
Formation of cyclic nucleic acid adducts from some simple alpha, beta-unsaturated carbonyl compounds and cyclic nitrosamines.
IARC scientific publications 1986;(70):207-25.
1985: Amin S; Huie K; Melikian A A; Leszczynska J M; Hecht S S
Comparative metabolic activation in mouse skin of the weak carcinogen 6-methylchrysene and the strong carcinogen 5-methylchrysene.
Cancer research 1985;45(12 Pt 1):6406-42.
1985: Chung F L; Hecht S S
Formation of the cyclic 1,N2-glyoxal-deoxyguanosine adduct upon reaction of N-nitroso-2-hydroxymorpholine with deoxyguanosine.
Carcinogenesis 1985;6(11):1671-3.
1985: Castonguay A; Foiles P G; Trushin N; Hecht S S
Study of DNA methylation by tobacco-specific N-nitrosamines.
Environmental health perspectives 1985;62():197-202.
1985: Amin S; Huie K; Hecht S S
Mutagenicity and tumor initiating activity of methylated benzo[b]fluoranthenes.
Carcinogenesis 1985;6(7):1023-5.
1985: Murphy S E; Hecht S S
Dual-label high-performance liquid chromatographic assay for femtomole levels of benzo[a]pyrene metabolites.
Analytical biochemistry 1985;146(2):442-7.
1985: Melikian A A; Hecht S S; Hoffmann D; Pataki J; Harvey R G
Analysis of syn- and anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene -deoxyribonucleoside adducts by boronate chromatography.
Cancer letters 1985;27(1):91-7.
1985: Melikian A A; Leszczynska J M; Amin S; Hecht S S; Hoffmann D; Pataki J; Harvey R G
Rates of hydrolysis and extents of DNA binding of 5-methylchrysene dihydrodiol epoxides.
Cancer research 1985;45(5):1990-6.
1985: Amin S; Hussain N; Balanikas G; Huie K; Hecht S S
Mutagenicity and tumor initiating activity of methylated benzo[k] fluoranthenes.
Cancer letters 1985;26(3):343-7.
1985: Chung F L; Wang M Y; Hecht S S
Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver.
Carcinogenesis 1985;6(4):539-43.
1985: el-Bayoumy K; O'Donnell M; Hecht S S; Hoffmann D
On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke.
Carcinogenesis 1985;6(4):505-7.
1985: Hecht S S; Radok L; Amin S; Huie K; Melikian A A; Hoffmann D; Pataki J; Harvey R G
Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin.
Cancer research 1985;45(4):1449-52.
1985: Carmella S G; Hecht S S
High-performance liquid chromatographic analysis of metabolites of the nicotine-derived nitrosamines, N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Analytical biochemistry 1985;145(2):239-44.
1985: Hoffmann D; Hecht S S
Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.
Cancer research 1985;45(3):935-44.
1985: Hoffmann D; Lavoie E J; Hecht S S
Nicotine: a precursor for carcinogens.
Cancer letters 1985;26(1):67-75.
1985: Hecht S S
Chemical carcinogenesis: an overview.
Clinical physiology and biochemistry 1985;3(2-3):89-97.
1984: Hecht S S
N-Nitroso-2-hydroxymorpholine, a mutagenic metabolite of N-nitrosodiethanolamine.
Carcinogenesis 1984;5(12):1745-7.
1984: El-Bayoumy K; Hecht S S; Sackl T; Stoner G D
Tumorigenicity and metabolism of 1-nitropyrene in A/J mice.
Carcinogenesis 1984;5(11):1449-52.
1984: Zacharias D E; Kashino S; Glusker J P; Harvey R G; Amin S; Hecht S S
The bay-region geometry of some 5-methylchrysenes: steric effects in 5,6- and 5,12-dimethylchrysenes.
Carcinogenesis 1984;5(11):1421-30.
1984: El-Bayoumy K; Reddy B; Hecht S S
Identification of ring oxidized metabolites of 1-nitropyrene in the feces and urine of germfree F344 rats.
Carcinogenesis 1984;5(10):1371-3.
1984: El-Bayoumy K; Hecht S S
Metabolism of 1-nitro[U-4,5,9,10-14C]pyrene in the F344 rat.
Cancer research 1984;44(10):4317-22.
1984: Amin S; Camanzo J; Hecht S S
Inhibition by a peri-fluorine atom of 1,2-dihydrodiol formation as a basis for the lower tumorigenicity of 12-fluoro-5-methylchrysene than of 5-methylchrysene.
Cancer research 1984;44(9):3772-8.
1984: El-Bayoumy K; Hecht S S
Identification of trans-1,2-dihydro-1,2-dihydroxy-6-nitrochrysene as a major mutagenic metabolite of 6-nitrochrysene.
Cancer research 1984;44(8):3408-13.
1984: Hecht S S; Morrison J B; Young R
N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine.
Carcinogenesis 1984;5(7):979-81.
1984: Chung F L; Juchatz A; Vitarius J; Hecht S S
Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues.
Cancer research 1984;44(7):2924-8.
1984: Hecht S S; Morrison J B
A sensitive method for detecting in vivo formation of N-nitrosomorpholine and its application to rats given low doses of morpholine and sodium nitrite.
Cancer research 1984;44(7):2873-7.
1984: Castonguay A; Rivenson A; Trushin N; Reinhardt J; Spathopoulos S; Weiss C J; Reiss B; Hecht S S
Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N'-nitrosonornicotine in F344 rats.
Cancer research 1984;44(6):2285-90.
1984: Melikian A A; Amin S; Hecht S S; Hoffmann D; Pataki J; Harvey R G
Identification of the major adducts formed by reaction of 5-methylchrysene anti-dihydrodiol-epoxides with DNA in vitro.
Cancer research 1984;44(6):2524-9.
1984: Castonguay A; Tjälve H; Trushin N; Hecht S S
Perinatal metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in C57BL mice.
Journal of the National Cancer Institute 1984;72(5):1117-26.
1984: Chung F L; Young R; Hecht S S
Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde.
Cancer research 1984;44(3):990-5.
1984: Hoffmann D; Rivenson A; Amin S; Hecht S S
Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats.
Journal of cancer research and clinical oncology 1984;108(1):81-6.
1984: Castonguay A; Tharp R; Hecht S S
Kinetics of DNA methylation by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
IARC scientific publications 1984;(57):805-10.
1984: Chung F L; Juchatz A; Vitarius J; Reiss B; Hecht S S
Inhibition of target tissue activation of N'-nitrosonornicotine and N-nitrosopyrrolidine by dietary components.
IARC scientific publications 1984;(57):797-804.
1984: Tjälve H; Castonguay A; Hecht S S
Fate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in pregnant and newborn C57BL mice.
IARC scientific publications 1984;(57):787-96.
1984: Morrison J B; Hecht S S
A sensitive new method for the detection of N-nitrosomorpholine formation in vivo.
IARC scientific publications 1984;(57):185-92.
1984: Hecht S S; Castonguay A; Chung F L; Hoffmann D
Carcinogenicity and metabolic activation of tobacco-specific nitrosamines: current status and future prospects.
IARC scientific publications 1984;(57):763-78.
1984: Hoffmann D; Brunnemann K D; Adams J D; Hecht S S
Formation and analysis of N-nitrosamines in tobacco products and their endogenous formation in consumers.
IARC scientific publications 1984;(57):743-62.
1983: Castonguay A; Stoner G D; Schut H A; Hecht S S
Metabolism of tobacco-specific N-nitrosamines by cultured human tissues.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(21):6694-7.
1983: Hecht S S; El-Bayoumy K; Rivenson A; Fiala E S
Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.
Cancer letters 1983;20(3):349-54.
1983: Hecht S S; Young R; Maeura Y
Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N'-nitrosonornicotine and N'-nitrosonornicotine-1-N-oxide.
Cancer letters 1983;20(3):333-40.
1983: Hecht S S; Adams J D; Numoto S; Hoffmann D
Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation.
Carcinogenesis 1983;4(10):1287-90.
1983: Brittebo E B; Castonguay A; Furuya K; Hecht S S
Metabolism of tobacco-specific nitrosamines by cultured rat nasal mucosa.
Cancer research 1983;43(9):4343-8.
1983: El-Bayoumy K; Sharma C; Louis Y M; Reddy B; Hecht S S
The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans.
Cancer letters 1983;19(3):311-6.
1983: El-Bayoumy K; Hecht S S
Identification and mutagenicity of metabolites of 1-nitropyrene formed by rat liver.
Cancer research 1983;43(7):3132-7.
1983: Hoffman D; Rivenson A; Adams J D; Juchatz A; Vinchkoski N; Hecht S S
Effects of route of administration and dose on the carcinogenicity of N-nitrosodiethanolamine in the Syrian golden hamster.
Cancer research 1983;43(6):2521-4.
1983: Hoffmann D; Hecht S S; Wynder E L
Tumor promoters and cocarcinogens in tobacco carcinogenesis.
Environmental health perspectives 1983;50():247-57.
1983: Chung F L; Hecht S S
Formation of cyclic 1,N2--adducts by reaction of deoxyguanosine with alpha-acetoxy-N-nitrosopyrrolidine, 4-(carbethoxynitrosamino)butanal, or crotonaldehyde.
Cancer research 1983;43(3):1230-5.
1983: Castonguay A; Lin D; Stoner G D; Radok P; Furuya K; Hecht S S; Schut H A; Klaunig J E
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.
Cancer research 1983;43(3):1223-9.
1983: Castonguay A; Tjälve H; Hecht S S
Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats.
Cancer research 1983;43(2):630-8.
1983: Morrison J B; Hecht S S; Wenninger J A
N-nitroso-N-methyloctadecylamine in hair-care products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1983;21(1):69-73.
1983: Melikian A A; LaVoie E J; Hecht S S; Hoffmann D
5-Methylchrysene metabolism in mouse epidermis in vivo, diol epoxide--DNA adduct persistence, and diol epoxide reactivity with DNA as potential factors influencing the predominance of 5-methylchrysene-1,2-diol-3,4-epoxide--DNA adducts in mouse epidermis.
Carcinogenesis 1983;4(7):843-9.
1983: Hoffmann D; Wynder E L; Rivenson A; LaVoie E J; Hecht S S
Skin bioassays in tobacco carcinogenesis.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1983;26():43-67.
1983: Hoffmann D; Hecht S S
II.2.a General aspects.
IARC scientific publications 1983;(45):63-7.
1983: Eisenbrand G; Archer M; Brunnemann K D; Fine D H; Hecht S S; Hoffmann D; Krull J; Webb K S
I.3 Problems of contamination and artefact formation in nitrosamine sampling and analysis.
IARC scientific publications 1983;(45):25-34.
1983: Hecht S S; Adams J D; Hoffmann D
II.2.d Tobacco-specific nitrosamines in tobacco and tobacco smoke.
IARC scientific publications 1983;(45):93-101.
1983: Hecht S S; Adams J D; Hoffmann D
IV.6 HPLC-TEA of tobacco-specific nitrosamines.
IARC scientific publications 1983;(45):429-36.
1983: Hecht S S; Lin D; Castonguay A
Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Carcinogenesis 1983;4(3):305-10.
1982: Carmella S G; La Voie E J; Hecht S S
Quantitative analysis of catechol and 4-methylcatechol in human urine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1982;20(5):587-90.
1982: Morrison J B; Hecht S S
N-Nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in household dishwashing liquids.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1982;20(5):583-6.
1982: El-Bayoumy K; Hecht S S; Hoffmann D
Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons.
Cancer letters 1982;16(3):333-7.
1982: Brunnemann K D; Hecht S S; Hoffmann D
N-nitrosamines: environmental occurrence, in vivo formation and metabolism.
Journal of toxicology. Clinical toxicology 1982;19(6-7):661-88.
1982: Hecht S S; El-Bayoumy K; Rivenson A; Fiala E
Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats.
Cancer letters 1982;16(1):103-8.
1982: Hecht S S; Morrison J B; Wenninger J A
N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1982;20(2):165-9.
1982: EL-Bayoumy K; Hecht S S
Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver.
Cancer research 1982;42(4):1243-8.
1982: Melikian A A; LaVoie E J; Hecht S S; Hoffmann D
Influence of bay-region methyl group on formation of 5-methylchrysene dihydrodiol epoxide:DNA adducts in mouse skin.
Cancer research 1982;42(4):1239-42.
1982: Hecht S S; Young R
Regiospecificity in the metabolism of the homologous cyclic nitrosamines, N'-nitrosonornicotine and N'-nitrosoanabasine.
Carcinogenesis 1982;3(10):1195-9.
1982: Amin S; Camanzo J; Hecht S S
Identification of metabolites of 5,11-dimethylchrysene and 5,12-dimethylchrysene and the influence of a peri-methyl group on their formation.
Carcinogenesis 1982;3(10):1159-63.
1982: Hecht S S; Young R; Rivenson A; Hoffmann D
On the metabolic activation of N-nitrosomorpholine and N'-nitrosonornicotine: effects of deuterium substitution.
IARC scientific publications 1982;(41):499-507.
1982: Hoffmann D; Brunnemann K D; Rivenson A; Hecht S S
N-nitrosodiethanolamine: analysis, formation in tobacco products and carcinogenicity in Syrian golden hamsters.
IARC scientific publications 1982;(41):299-308.
1982: LaVoie E J; Hecht S S; Bedenko V; Hoffmann D
Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene.
Carcinogenesis 1982;3(8):841-6.
1982: Hecht S S; Reiss B; Lin D; Williams G M
Metabolism of N'-nitrosonornicotine by cultured rat esophagus.
Carcinogenesis 1982;3(4):453-6.
1982: Amin S; LaVoie E J; Hecht S S
Identification of metabolites of benzo[b]fluoranthene.
Carcinogenesis 1982;3(2):171-4.
1982: LaVoie E J; Amin S; Hecht S S; Furuya K; Hoffmann D
Tumour initiating activity of dihydrodiols of benzo[b]fluoranthene, benzo[j]fluoranthene, and benzo[k]fluoranthene.
Carcinogenesis 1982;3(1):49-52.
1982: McCoy G D; Hecht S S; McCoy E C
Comparison of microsomal inducer pretreatment on the in vitro alpha-hydroxylation and mutagenicity of N-Nitrosopyrrolidine in rat and hamster liver.
Environmental mutagenesis 1982;4(3):221-30.
1982: McCoy G; Katayama S; Young R; Wyatt M; Hecht S
Influence of chronic ethanol consumption on the metabolism and carcinogenicity of tobacco-related nitrosamines.
IARC scientific publications 1982;(41):635-42.
1982: Hoffmann D; Adams J D; Brunnemann K D; Rivenson A; Hecht S S
Tobacco specific N-nitrosamines: occurrence and bioassays.
IARC scientific publications 1982;(41):309-18.
1981: Hecht S S; Young R
Metabolic alpha-hydroxylation of N-nitrosomorpholine and 3,3,5,5-tetradeutero-N-nitrosomorpholine in the F344 rat.
Cancer research 1981;41(12 Pt 1):5039-43.
1981: El-Bayoumy K; LaVoie E J; Tulley-Freiler L; Hecht S S
Effects of ortho-methyl substituents on the mutagenicity of aminobiphenyls and aminonaphthalenes.
Mutation research 1981;90(4):345-54.
1981: Hecht S S; LaVoie E J; Bedenko V; Pingaro L; Katayama S; Hoffmann D; Sardella D J; Boger E; Lehr R E
Reduction of tumorigenicity and of dihydrodiol formation by fluorine substitution in the angular rings of dibenzo(a,i)pyrene.
Cancer research 1981;41(11 Pt 1):4341-5.
1981: McCoy G D; Hecht S S; Katayama S; Wynder E L
Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters.
Cancer research 1981;41(7):2849-54.
1981: Hoffmann D; Castonguay A; Rivenson A; Hecht S S
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters.
Cancer research 1981;41(6):2386-93.
1981: El-Bayoumy K; Lavoie E J; Hecht S S; Fow E A; Hoffmann D
The influence of methyl substitution of the mutagenicity of nitronaphthalenes and nitrobiphenyls.
Mutation research 1981;81(2):143-53.
1981: McCoy G D; Chen C B; Hecht S S
Influence of mixed-function oxidase inducers on the in vitro metabolism of N'-nitrosonornicotine by rat and hamster liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1981;9(2):168-9.
1981: Hecht S S; Carmella S; Mori H; Hoffmann D
A study of tobacco carcinogenesis. XX. Role of catechol as a major cocarcinogen in the weakly acidic fraction of smoke condensate.
Journal of the National Cancer Institute 1981;66(1):163-9.
1981: Hecht S S; Lin D; Chen C B
Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine.
Carcinogenesis 1981;2(9):833-8.
1981: Amin S; Juchatz A; Furuya K; Hecht S S
Effects of fluorine substitution on the tumor initiating activity and metabolism of 5-hydroxymethylchrysene, a tumorigenic metabolite of 5-methylchrysene.
Carcinogenesis 1981;2(10):1027-32.
1981: Fiala E S; Kohl N E; Hecht S S; Yang J J; Shimada T
The formation of azoxy-2-phenylethane during the biological oxidation of phenylethylamine by rabbit liver microsomes.
Carcinogenesis 1981;2(3):165-73.
1980: LaVoie E J; Hecht S S; Amin S; Bedenko V; Hoffmann D
Identification of mutagenic dihydrodiols as metabolites of benzo(j)fluoranthene and benzo(k)fluoranthene.
Cancer research 1980;40(12):4528-32.
1980: Hecht S S; Young R; Chen C B
Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
Cancer research 1980;40(11):4144-50.
1980: Hecht S S; Chen C B; Hoffmann D
Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine.
Journal of medicinal chemistry 1980;23(11):1175-8.
1980: McCoy G D; Hecht S S; Wynder E L
The roles of tobacco, alcohol, and diet in the etiology of upper alimentary and respiratory tract cancers.
Preventive medicine 1980;9(5):622-9.
1980: Hecht S S; Rivenson A; Hoffmann D
Tumor-initiating activity of dihydrodiols formed metabolically from 5-methylchrysene.
Cancer research 1980;40(5):1396-9.
1980: Hecht S S; Chen C B; Ohmori T; Hoffmann D
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Cancer research 1980;40(2):298-302.
1980: Hecht S S; Chen C B; Young R; Lin D; Hoffmann D
Metabolism of the tobacco specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
IARC scientific publications 1980;(31):755-65.
1980: Hoffmann D; Adams J D; Piade J J; Hecht S S
Chemical studies on tobacco smoke LXVIII. Analysis of volatile and tobacco-specific nitrosamines in tobacco products.
IARC scientific publications 1980;(31):507-16.
1980: Chen C B; Hecht S S; McCoy G D; Hoffmann D
Assays for metabolic alpha-hydroxylation of N'-nitrosonornicotine and N-nitrosopyrrolidine and the influence of modifying factors.
IARC scientific publications 1980;(31):349-59.
1979: Chen C H; Fung P T; Hecht S S
Assay for microsomal alpha-hydroxylation of N'-nitrosonornicotine and determination of the deuterium isotope effect for alpha-hydroxylation.
Cancer research 1979;39(12):5057-62.
1979: Hecht S S; Amin S; Rivenson A; Hoffmann D
Tumor initiating activity of 5,11-dimethylchrysene and the structural requirements favoring carcinogenicity of methylated polynuclear aromatic hydrocarbons.
Cancer letters 1979;8(1):65-70.
1979: Hecht S S; Chen C H; McCoy G D; Hoffmann D; Domellöf L
Alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine by human liver microsomes.
Cancer letters 1979;8(1):35-41.
1979: Amin S; Hecht S S; LaVoie E; Hoffmann D
Synthesis and mutagenicity of 5,11-dimethylchrysene and some methyl-oxidized derivatives of 5-methylchrysene.
Journal of medicinal chemistry 1979;22(11):1336-40.
1979: Hecht S S; LaVole E; Mazzarese R; Hirota N; Ohmori T; Hoffmann D
Comparative mutagenicity, tumor-initiating activity, carcinogenicity, and in vitro metabolism of fluorinated 5-methylchrysenes.
Journal of the National Cancer Institute 1979;63(3):855-61.
1979: Hecht S S; El-Bayoumy K; Tulley L; LaVoie E
Structure-mutagenicity relationships of N-oxidized derivatives of aniline, o-toluidine, 2'-methyl-4-aminobiphenyl, and 3,2'-dimethyl-4-aminobiphenyl.
Journal of medicinal chemistry 1979;22(8):981-7.
1979: Hoffmann D; Adams J D; Brunnemann K D; Hecht S S
Assessment of tobacco-specific N-nitrosamines in tobacco products.
Cancer research 1979;39(7 Pt 1):2505-9.
1979: Hecht S S; Grabowski W; Groth K
Analysis of faeces for benzo[a]pyrene after consumption of charcoal-broiled beef by rats and humans.
Food and cosmetics toxicology 1979;17(3):223-7.
1979: McCoy G D; Chen C H; Hecht S S; McCoy E C
Enhanced metabolism and mutagenesis of nitrosopyrrolidine in liver fractions isolated from chronic ethanol-consuming hamsters.
Cancer research 1979;39(3):793-6.
1979: Hoffmann D; Rivenson A; Hecht S S; Hilfrich J; Kobayashi N; Wynder E L
Model studies in tobacco carcinogenesis with the Syrian golden hamster.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1979;24():370-90.
1978: Chen C B; McCoy G D; Hecht S S; Hoffmann D; Wynder E L
High pressure liquid chromatographic assay for alpha hydroxylation of N-nitrosopyrrolidine by isolated rat liver microsomes.
Cancer research 1978;38(11 Pt 1):3812-6.
1978: Chen C B; Hecht S S; Hoffmann D
Metabolic alpha-hydroxylation of the tobacco-specific carcinogen, N'-nitrosonornicotine.
Cancer research 1978;38(11 Pt 1):3639-45.
1978: Hecht S S; Hirota N; Hoffman D
Comparative tumor initiating activity of 10-methylbenzo-[a]pyrene, 7,10-dimethylbenzo[a]pyrene and benzo[a]pyrene.
Cancer letters 1978;5(3):179-83.
1978: Hecht S S; LaVoie E; Mazzarese R; Amin S; Bedenko V; Hoffmann D
1,2-dihydro-1,2-dihydroxy-5-methylchrysene, a major activated metabolite of the environmental carcinogen 5-methylchrysene.
Cancer research 1978;38(7):2191-4.
1978: Hecht S S; Hirota N; Loy M; Hoffmann D
Tumor-initiating activity of fluorinated 5-methylchrysenes.
Cancer research 1978;38(6):1694-8.
1978: Hecht S S; Chen C B; Hirota N; Ornaf R M; Tso T C; Hoffmann D
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice.
Journal of the National Cancer Institute 1978;60(4):819-24.
1978: Hecht S S; Chen C B; Ornaf R M; Jacobs E; Adams J D; Hoffmann D
Reaction of nicotine and sodium nitrite: formation of nitrosamines and fragmentation of the pyrrolidine ring.
The Journal of organic chemistry 1978;43(1):72-6.
1978: Hecht S S; Chen C B; Hoffmann D
Evidence for metabolic alpha hydroxylation of N-nitrosopyrrolidine.
Cancer research 1978;38(1):215-8.
1978: Hecht S S; Loy M; Mazzarese R; Hoffmann D
Synthesis and mutagenicity of modified chrysenes related to the carcinogen, 5-methylchrysene.
Journal of medicinal chemistry 1978;21(1):38-44.
1978: Hecht S S; Chen C B; Ornaf R M; Hoffmann D; Tso T C
Chemical studies on tobacco smoke LVI. Tobacco specific nitrosamines: origins, carcinogenicity and metabolism.
IARC scientific publications 1978;(19):395-413.
1977: Mirvish S S; Sams J; Hecht S S
Kinetics of nornicotine and anabasine nitrosation in relation to N'-nitrosonornicotine occurrence in tobacco and to tobacco-induced cancer.
Journal of the National Cancer Institute 1977;59(4):1211-3.
1977: Hoffmann D; Dong M; Hecht S S
Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen.
Journal of the National Cancer Institute 1977;58(6):1841-4.
1977: Hilfrich J; Hecht S S; Hoffmann D
A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters.
Cancer letters 1977;2(3):169-75.
1976: Hoffmann D; Hecht S S; Ornaf R M; Wynder E L; Tso T C
Chemical studies on tobacco smoke. XLII. Nitrosonornicotine: presence in tobacco, formation and carcinogenicity.
IARC scientific publications 1976;(14):307-20.
1975: Hecht S S; Thorne R L; Maronpot R R; Hoffmann D
A study of tobacco carcinogenesis. XIII. Tumor-promoting subfractions of the weakly acidic fraction.
Journal of the National Cancer Institute 1975;55(6):1329-36.
1975: Hoffmann D; Raineri R; Hecht S S; Maronpot R; Wynder E L
A study of tobacco carcinogenesis. XIV. Effects of N'-nitrosonornicotine and N'-nitrosonanabasine in rats.
Journal of the National Cancer Institute 1975;55(4):977-81.
1975: Hecht S S; Ornaf R M; Hoffmann D
Determination of N'-nitrosonornicotine in tobacco by high speed liquid chromatography.
Analytical chemistry 1975;47(12):2046-8.
1975: Hecht S S; Ornaf R M; Hoffmann D
Chemical studies on tobacco smoke. XXXIII. N' -nitrosonornicotine in tobacco: analysis of possible contributing factors and biologic implications.
Journal of the National Cancer Institute 1975;54(5):1237-44.
1974: Hecht S S; Bondinell W E; Hoffmann D
Chrysene and methylchrysenes: presence in tobacco smoke and carcinogenicity.
Journal of the National Cancer Institute 1974;53(4):1121-33.
1974: Hoffmann D; Hecht S S; Ornaf R M; Wynder E L
N'-nitrosonornicotine in tobacco.
Science (New York, N.Y.) 1974;186(4160):265-7.

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