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Diane Heck

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Chemicals & Drugs

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Laurie B Joseph; Debra L Laskin; Patrick Sinko; Michael C Babin; Adrienne T Black; Robert P Casillas; Jessica A Cervelli; Donald R Gerecke; Diane E Heck; Jeffrey D Laskin
Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.
Adrienne T Black; Patrick J Hayden; Robert P Casillas; Diane E Heck; Donald R Gerecke; Patrick Sinko; Debra L Laskin; Jeffrey D Laskin
Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.
Adrienne T Black; Marion K Gordon; Diane E Heck; Michael A Gallo; Debra L Laskin; Jeffrey D Laskin
UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells.

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2011: Laurie B Joseph; Debra L Laskin; Patrick Sinko; Michael C Babin; Adrienne T Black; Robert P Casillas; Jessica A Cervelli; Donald R Gerecke; Diane E Heck; Jeffrey D Laskin
Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.
Experimental and molecular pathology 2011;91(2):515-27.
2011: Adrienne T Black; Patrick J Hayden; Robert P Casillas; Diane E Heck; Donald R Gerecke; Patrick Sinko; Debra L Laskin; Jeffrey D Laskin
Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.
Toxicology and applied pharmacology 2011;253(2):112-20.
2011: Adrienne T Black; Marion K Gordon; Diane E Heck; Michael A Gallo; Debra L Laskin; Jeffrey D Laskin
UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells.
Biochemical pharmacology 2011;81(7):873-80.
2011: Karma C Fussell; Ronald G Udasin; Joshua P Gray; Vladimir Mishin; Peter J S Smith; Diane E Heck; Jeffrey D Laskin
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.
Free radical biology & medicine 2011;50(7):874-82.
2011: Barry Weinberger; Jeffrey D Laskin; Vasanthi R Sunil; Patrick J Sinko; Diane E Heck; Debra L Laskin
Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity.
Pulmonary pharmacology & therapeutics 2011;24(1):92-9.
2010: Adrienne T Black; Patrick J Hayden; Robert P Casillas; Diane E Heck; Donald R Gerecke; Patrick Sinko; Debra L Laskin; Jeffrey D Laskin
Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.
Toxicology and applied pharmacology 2010;249(2):178-87.
2010: Diane E Heck; Michael Shakarjian; Hong Duck Kim; Jeffrey D Laskin; Anna M Vetrano
Mechanisms of oxidant generation by catalase.
Annals of the New York Academy of Sciences 2010;1203():120-5.
2010: Jeffrey D Laskin; Adrienne T Black; Yi-Hua Jan; Patrick J Sinko; Ned D Heindel; Vasanthi Sunil; Diane E Heck; Debra L Laskin
Oxidants and antioxidants in sulfur mustard-induced injury.
Annals of the New York Academy of Sciences 2010;1203():92-100.
2010: Diane E Heck
It's the plastic!: commentary on the article by Vetrano et al. on page 134.
Pediatric research 2010;68(2):99.
2010: Yi-Hua Jan; Diane E Heck; Joshua P Gray; Haiyan Zheng; Robert P Casillas; Debra L Laskin; Jeffrey D Laskin
Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells.
Chemical research in toxicology 2010;23(6):1045-53.
2010: Adrienne T Black; Laurie B Joseph; Robert P Casillas; Diane E Heck; Donald R Gerecke; Patrick Sinko; Debra L Laskin; Jeffrey D Laskin
Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide.
Toxicology and applied pharmacology 2010;245(3):352-60.
2010: Yun Wang; Joshua P Gray; Vladimir Mishin; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity.
Molecular cancer therapeutics 2010;9(6):1852-63.
2010: Vladimir Mishin; Joshua P Gray; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes.
Free radical biology & medicine 2010;48(11):1485-91.
2010: Sherri Young; Karine Fabio; Christophe Guillon; Pramod Mohanta; Timothy A Halton; Diane E Heck; Robert A Flowers; Jeffrey D Laskin; Ned D Heindel
Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction.
Bioorganic & medicinal chemistry letters 2010;20(9):2987-90.
2010: Michael P Shakarjian; Diane E Heck; Joshua P Gray; Patrick J Sinko; Marion K Gordon; Robert P Casillas; Ned D Heindel; Donald R Gerecke; Debra L Laskin; Jeffrey D Laskin
Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(1):5-19.
2008: Adrienne T Black; Joshua P Gray; Michael P Shakarjian; Vladimir Mishin; Debra L Laskin; Diane E Heck; Jeffrey D Laskin
UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes.
Toxicology and applied pharmacology 2008;232(1):14-24.
2008: Adrienne T Black; Joshua P Gray; Michael P Shakarjian; Debra L Laskin; Diane E Heck; Jeffrey D Laskin
Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat.
Toxicology and applied pharmacology 2008;231(3):384-92.
2008: Yun Wang; Joshua P Gray; Vladimir Mishin; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity.
Free radical biology & medicine 2008;44(6):1169-79.
2008: Adrienne T Black; Joshua P Gray; Michael P Shakarjian; Debra L Laskin; Diane E Heck; Jeffrey D Laskin
Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes.
Carcinogenesis 2008;29(1):219-25.
2007: Vasanthi R Sunil; Kinal J Patel; Marit Nilsen-Hamilton; Diane E Heck; Jeffrey D Laskin; Debra L Laskin
Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver.
Experimental and molecular pathology 2007;83(2):177-87.
2007: Joshua P Gray; Diane E Heck; Vladimir Mishin; Peter J S Smith; Jun-Yan Hong; Mona Thiruchelvam; Deborah A Cory-Slechta; Debra L Laskin; Jeffrey D Laskin
Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase.
The Journal of biological chemistry 2007;282(11):7939-49.
2005: Christine A Martey; Anna M Vetrano; marilyn whittemore; Thomas M Mariano; Diane E Heck; Debra L Laskin; Ned D Heindel; Jeffrey D Laskin
Inhibition of interferon-gamma signaling by a mercurio-substituted dihydropsoralen in murine keratinocytes.
Biochemical pharmacology 2005;70(12):1726-34.
2005: Anna M Vetrano; Diane E Heck; Thomas M Mariano; Vladimir Mishin; Debra L Laskin; Jeffrey D Laskin
Characterization of the oxidase activity in mammalian catalase.
The Journal of biological chemistry 2005;280(42):35372-81.
2005: Barry Weinberger; Nazeeh Hanna; Jeffrey D Laskin; Diane E Heck; Carol R Gardner; Donald R Gerecke; Debra L Laskin
Mechanisms mediating the biologic activity of synthetic proline, glycine, and hydroxyproline polypeptides in human neutrophils.
Mediators of inflammation 2005;2005(1):31-8.
2005: Nazeeh Hanna; Pedro Vasquez; Petra Pham; Diane E Heck; Jeffrey D Laskin; Debra L Laskin; Barry Weinberger
Mechanisms underlying reduced apoptosis in neonatal neutrophils.
Pediatric research 2005;57(1):56-62.
2004: Diane E Heck; Donald R Gerecke; Anna M Vetrano; Jeffrey D Laskin
Solar ultraviolet radiation as a trigger of cell signal transduction.
Toxicology and applied pharmacology 2004;195(3):288-97.
2003: Diane E Heck; Anna M Vetrano; Thomas M Mariano; Jeffrey D Laskin
UVB light stimulates production of reactive oxygen species: unexpected role for catalase.
The Journal of biological chemistry 2003;278(25):22432-6.
2002: Runa Sur; Diane E Heck; Thomas M Mariano; Yang Jin; William J Murphy; Jeffrey D Laskin
UVB light suppresses nitric oxide production by murine keratinocytes and macrophages.
Biochemical pharmacology 2002;64(10):1469-81.
2002: Jeffrey D Laskin; Diane E Heck; Debra L Laskin
The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(2):289-91.
2002: Blase Billack; Diane E Heck; Thomas M Mariano; Carol R Gardner; Runa Sur; Debra L Laskin; Jeffrey D Laskin
Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells.
American journal of physiology. Cell physiology 2002;283(4):C1267-77.
2002: Christine A Martey; Anna M Vetrano; marilyn whittemore; Thomas M Mariano; Shannon L Gentile; Diane E Heck; Debra L Laskin; Ned D Heindel; Jeffrey D Laskin
Mechanisms of growth inhibition in keratinocytes by mercurio-substituted 4',5'-dihydropsoralens.
Biochemical pharmacology 2002;63(11):2001-9.
2002: Barry Weinberger; Debra L Laskin; Diane E Heck; Jeffrey D Laskin
Oxygen toxicity in premature infants.
Toxicology and applied pharmacology 2002;181(1):60-7.
2002: Debra L Laskin; Ladan Fakhrzadeh; Diane E Heck; Donald R Gerecke; Jeffrey D Laskin
Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity.
Molecular and cellular biochemistry 2002;234-235(1-2):91-8.
2002: Thomas M Mariano; Anna M Vetrano; Shannon L Gentile; Diane E Heck; marilyn whittemore; Christophe D Guillon; Ivan Jabin; Robert D Rapp; Ned D Heindel; Jeffrey D Laskin
Cell-impermeant pyridinium derivatives of psoralens as inhibitors of keratinocyte growth.
Biochemical pharmacology 2002;63(1):31-9.
2001: Barry Weinberger; Debra L Laskin; Thomas M Mariano; Vasanthi R Sunil; C J DeCoste; Diane E Heck; Carol R Gardner; Jeffrey D Laskin
Mechanisms underlying reduced responsiveness of neonatal neutrophils to distinct chemoattractants.
Journal of leukocyte biology 2001;70(6):969-76.
2001: Blase Billack; Diane E Heck; D M Porterfield; Robert Paul Malchow; P J Smith; Carol R Gardner; Debra L Laskin; Jeffrey D Laskin
Minimal amidine structure for inhibition of nitric oxide biosynthesis.
Biochemical pharmacology 2001;61(12):1581-6.
2001: Jeffrey D Laskin; Diane E Heck; Carol R Gardner; Debra L Laskin
Prooxidant and antioxidant functions of nitric oxide in liver toxicity.
Antioxidants & redox signaling 2001;3(2):261-71.
2001: Diane E Heck
*NO, RSNO, ONOO-, NO+, *NOO, NOx--dynamic regulation of oxidant scavenging, nitric oxide stores, and cyclic GMP-independent cell signaling.
Antioxidants & redox signaling 2001;3(2):249-60.
2001: Lisa Morio; Hawjyh Chiu; K A Sprowles; Peihong Zhou; Diane E Heck; Marion K Gordon; Debra L Laskin
Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice.
Toxicology and applied pharmacology 2001;172(1):44-51.
2001: Barry Weinberger; K Weiss; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Pharmacologic therapy of persistent pulmonary hypertension of the newborn.
Pharmacology & therapeutics 2001;89(1):67-79.
2001: Barry Weinberger; Debra L Laskin; Diane E Heck; Jeffrey D Laskin
The toxicology of inhaled nitric oxide.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(1):5-16.
1999: Barry Weinberger; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Nitric oxide in the lung: therapeutic and cellular mechanisms of action.
Pharmacology & therapeutics 1999;84(3):401-11.
1998: Debra L Laskin; Vasanthi R Sunil; Y Guo; Diane E Heck; Jeffrey D Laskin
Increased nitric oxide synthase in the lung after ozone inhalation is associated with activation of NF-kappa B.
Environmental health perspectives 1998;106 Suppl 5():1175-8.
1998: Carol R Gardner; Diane E Heck; C S Yang; P E Thomas; X J Zhang; G L DeGeorge; Jeffrey D Laskin; Debra L Laskin
Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat.
Hepatology (Baltimore, Md.) 1998;27(3):748-54.
1997: G L DeGeorge; Diane E Heck; Jeffrey D Laskin
Arginine metabolism in keratinocytes and macrophages during nitric oxide biosynthesis: multiple modes of action of nitric oxide synthase inhibitors.
Biochemical pharmacology 1997;54(1):103-12.
1996: Debra L Laskin; Diane E Heck; C J Punjabi; Jeffrey D Laskin
Role of nitric oxide in hematosuppression and benzene-induced toxicity.
Environmental health perspectives 1996;104 Suppl 6():1283-7.
1996: Y Jin; Diane E Heck; G DeGeorge; Y Tian; Jeffrey D Laskin
5-Fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells.
Cancer research 1996;56(9):1978-82.
1995: Debra L Laskin; M Rodriguez del Valle; Diane E Heck; S M Hwang; S T Ohnishi; S K Durham; N L Goller; Jeffrey D Laskin
Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression.
Hepatology (Baltimore, Md.) 1995;22(1):223-34.
1994: S M Hwang; C A Lopez; Diane E Heck; C R Gardner; Debra L Laskin; Jeffrey D Laskin; D T Denhardt
Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells.
The Journal of biological chemistry 1994;269(1):711-5.
1992: Diane E Heck; Debra L Laskin; C R Gardner; Jeffrey D Laskin
Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing.
The Journal of biological chemistry 1992;267(30):21277-80.
1992: C J Punjabi; Debra L Laskin; Diane E Heck; Jeffrey D Laskin
Production of nitric oxide by murine bone marrow cells. Inverse correlation with cellular proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2179-84.