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John Heckels

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Meningococcal Infections

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Publications

TOP 3
Miao-Chiu Hung; John E Heckels; Myron Christodoulides
The adhesin complex protein (ACP) of Neisseria meningitidis is a new adhesin with vaccine potential.
Khalil Alkuwaity; Kelly S Doran; John E Heckels; Alexander Taylor; Myron Christodoulides
Group B Streptococcus interactions with human meningeal cells and astrocytes in vitro.
Luis Velasquez; Myron Christodoulides; Katherine García; John E Heckels; Francisco Morales; Pedro A Orihuela; Paula I Rodas; Hugo Cardenas
Neisseria gonorrhoeae pilus attenuates cytokine response of human fallopian tube explants.

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All Publications

2013: Miao-Chiu Hung; John E Heckels; Myron Christodoulides
The adhesin complex protein (ACP) of Neisseria meningitidis is a new adhesin with vaccine potential.
mBio 2013;4(2):.
2012: Khalil Alkuwaity; Kelly S Doran; John E Heckels; Alexander Taylor; Myron Christodoulides
Group B Streptococcus interactions with human meningeal cells and astrocytes in vitro.
PloS one 2012;7(8):e42660.
2012: Luis Velasquez; Myron Christodoulides; Katherine García; John E Heckels; Francisco Morales; Pedro A Orihuela; Paula I Rodas; Hugo Cardenas
Neisseria gonorrhoeae pilus attenuates cytokine response of human fallopian tube explants.
Journal of biomedicine & biotechnology 2012;2012():491298.
2012: Jeannette Williams; Myron Christodoulides; John E Heckels
Analysis of the immune response to Neisseria meningitidis using a proteomics approach.
Methods in molecular biology (Clifton, N.J.) 2012;799():343-60.
2011: Miao-Chiu Hung; omar Salim; Jeannette Williams; John E Heckels; Myron Christodoulides
The Neisseria meningitidis macrophage infectivity potentiator protein induces cross-strain serum bactericidal activity and is a potential serogroup B vaccine candidate.
Infection and immunity 2011;79(9):3784-91.
2010: Pawan Kumar; Jeannette Williams; Kesta L Durkin; John E Heckels; Peter S Friedmann; Eugene Healy; Myron Christodoulides
Neuropeptide alpha-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitro.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2010;59(2):105-13.
2010: Katherine P García; Paulina S Rubilar; Macarena F Vargas; Hugo Cárdenas; Miguel A Rios; Pedro A Orihuela; Renato H Vargas; Juan Fuhrer; John E Heckels; Myron Christodoulides; Luis A Velásquez
Nitric oxide is not involved in Neisseria gonorrhoeae-induced cellular damage of human Fallopian tubes in vitro.
Biological research 2010;43(1):39-50.
2010: John E Heckels; Jeannette Williams
The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection.
Genome medicine 2010;2(7):43.
2009: Jeannette Williams; Paul J Skipp; C David O'Connor; Myron Christodoulides; John E Heckels
Immunoproteomic analysis of the development of natural immunity in subjects colonized by Neisseria meningitidis reveals potential vaccine candidates.
Infection and immunity 2009;77(11):5080-9.
2008: Kim Jemmett; Annalisa Macagno; Monica Molteni; John E Heckels; Carlo Rossetti; Myron Christodoulides
A cyanobacterial lipopolysaccharide antagonist inhibits cytokine production induced by Neisseria meningitidis in a human whole-blood model of septicemia.
Infection and immunity 2008;76(7):3156-63.
2008: Delin Zhu; Jeannette Williams; Jason Rice; Freda K Stevenson; John E Heckels; Myron Christodoulides
A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidis.
Infection and immunity 2008;76(1):334-8.
2007: Jeannette Williams; Paul J Skipp; Holly E Humphries; Myron Christodoulides; C David O'Connor; John E Heckels
Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant.
Infection and immunity 2007;75(3):1364-72.
2006: Mark I Fowler; Kiave Y Ho Wang Yin; Holly E Humphries; John E Heckels; Myron Christodoulides
Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis.
Infection and immunity 2006;74(11):6467-78.
2006: Priscilla Morales; Paz Reyes; Macarena Vargas; Miguel Rios; Mónica Imarai; Hugo Cardenas; Horacio B Croxatto; Pedro A Orihuela; Renato Vargas; Juan Fuhrer; John E Heckels; Myron Christodoulides; Luis Velasquez
Infection of human fallopian tube epithelial cells with Neisseria gonorrhoeae protects cells from tumor necrosis factor alpha-induced apoptosis.
Infection and immunity 2006;74(6):3643-50.
2006: Holly E Humphries; Jeannette Williams; Ramona Blackstone; Keith Jolley; Ho M Yuen; Myron Christodoulides; John E Heckels
Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis.
Vaccine 2006;24(1):36-44.
2005: J Zoe Jordens; John E Heckels
A novel porA-based real-time PCR for detection of meningococcal carriage.
Journal of medical microbiology 2005;54(Pt 5):463-6.
2005: Holly E Humphries; Martha Triantafilou; Benjamin L Makepeace; John E Heckels; Kathy Triantafilou; Myron Christodoulides
Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor (TLR)4 and TLR2 signalling.
Cellular microbiology 2005;7(3):415-30.
2004: J Zoe Jordens; Jeannette Williams; Graeme R Jones; Myron Christodoulides; John E Heckels
Development of immunity to serogroup B meningococci during carriage of Neisseria meningitidis in a cohort of university students.
Infection and immunity 2004;72(11):6503-10.
2004: Tamara Al-Bader; Keith Jolley; Holly E Humphries; Judith Holloway; John E Heckels; Amanda E Semper; Peter S Friedmann; Myron Christodoulides
Activation of human dendritic cells by the PorA protein of Neisseria meningitidis.
Cellular microbiology 2004;6(7):651-62.
2004: Mark I Fowler; Roy O Weller; John E Heckels; Myron Christodoulides
Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges.
Cellular microbiology 2004;6(6):555-67.
2004: Holly E Humphries; Jeannette Williams; Myron Christodoulides; John E Heckels
Recombinant meningococcal PorA protein, expressed using a vector system with potential for human vaccination, induces a bactericidal immune response.
Vaccine 2004;22(11-12):1564-9.
2003: Tamara Al-Bader; Myron Christodoulides; John E Heckels; Judith Holloway; Amanda E Semper; Peter S Friedmann
Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidis.
Infection and immunity 2003;71(10):5590-7.
2003: Jeannette Williams; Graeme R Jones; Myron Christodoulides; John E Heckels
Serological correlates of protection against meningococci in a cohort of university students, before and during an outbreak of serogroup C infection.
The Journal of infectious diseases 2003;187(9):1433-41.
2003: Kevin Maisey; Gino Nardocci; Mónica Imarai; Hugo Cardenas; Miguel Rios; Horacio B Croxatto; John E Heckels; Myron Christodoulides; Luis Velasquez
Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae.
Infection and immunity 2003;71(1):527-32.
2002: Holly E Humphries; Myron Christodoulides; John E Heckels
Expression of the class 1 outer-membrane protein of Neisseria meningitidis in Escherichia coli and purification using a self-cleavable affinity tag.
Protein expression and purification 2002;26(2):243-8.
2002: Myron Christodoulides; Benjamin L Makepeace; Kris A Partridge; Davindaur Kaur; Mark I Fowler; Roy O Weller; John E Heckels
Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines.
Infection and immunity 2002;70(8):4035-44.
2002: Claire Hoe; Jeannette Williams; Myron Christodoulides; John E Heckels
Immunization with the recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis.
Infection and immunity 2002;70(8):4028-34.
2002: J Zoe Jordens; Jeannette Williams; Graeme R Jones; John E Heckels
Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles.
Journal of clinical microbiology 2002;40(1):75-9.
2001: Keith Jolley; L Appleby; Claire Hoe; Myron Christodoulides; John E Heckels
Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococci.
Infection and immunity 2001;69(6):3809-16.
2001: Benjamin L Makepeace; PJ Watt; John E Heckels; Myron Christodoulides
Interactions of Neisseria gonorrhoeae with mature human macrophage opacity proteins influence production of proinflammatory cytokines.
Infection and immunity 2001;69(3):1909-13.
2001: John E Heckels; Myron Christodoulides
Epitope mapping.
Methods in molecular medicine 2001;66():361-70.
2001: Myron Christodoulides; Keith Jolley; John E Heckels
Recombinant proteins in vaccine development.
Methods in molecular medicine 2001;66():167-80.
2000: S J Hardy; Myron Christodoulides; Roy O Weller; John E Heckels
Interactions of Neisseria meningitidis with cells of the human meninges.
Molecular microbiology 2000;36(4):817-29.
2000: Graeme R Jones; Jeannette Williams; Myron Christodoulides; Keith Jolley; John E Heckels
Lack of immunity in university students before an outbreak of serogroup C meningococcal infection.
The Journal of infectious diseases 2000;181(3):1172-5.
2000: Myron Christodoulides; J Sylvia Everson; BL Liu; Paul R Lambden; PJ Watt; E J Thomas; John E Heckels
Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein.
Molecular microbiology 2000;35(1):32-43.
1999: Myron Christodoulides; E Rattue; John E Heckels
Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin.
Vaccine 1999;18(1-2):131-9.
1998: Myron Christodoulides; J L Brooks; E Rattue; John E Heckels
Immunization with recombinant class 1 outer-membrane protein from Neisseria meningitidis: influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci.
Microbiology (Reading, England) 1998;144 ( Pt 11)():3027-37.
1998: Graeme R Jones; Myron Christodoulides; J L Brooks; A R Miller; K A Cartwright; John E Heckels
Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization.
The Journal of infectious diseases 1998;178(2):451-9.
1998: S J Cooke; Keith Jolley; C A Ison; H Young; John E Heckels
Naturally occurring isolates of Neisseria gonorrhoeae, which display anomalous serovar properties, express PIA/PIB hybrid porins, deletions in PIB or novel PIA molecules.
FEMS microbiology letters 1998;162(1):75-82.
1997: S J Cooke; H de la Paz; C La Poh; C A Ison; John E Heckels
Variation within serovars of Neisseria gonorrhoeae detected by structural analysis of outer-membrane protein PIB and by pulsed-field gel electrophoresis.
Microbiology (Reading, England) 1997;143 ( Pt 4)():1415-22.
1997: N Johnson; Mark A Pickett; PJ Watt; Ian Clarke; John E Heckels
Construction of an epitope vector utilising the diphtheria toxin B-subunit.
FEMS microbiology letters 1997;146(1):91-6.
1996: S J Ward; D Scopes; Myron Christodoulides; Ian Clarke; John E Heckels
Expression of Neisseria meningitidis class 1 porin as a fusion protein in Escherichia coli: the influence of liposomes and adjuvants on the production of a bactericidal immune response.
Microbial pathogenesis 1996;21(6):499-512.
1995: J L Brooks; R J Fallon; John E Heckels
Sequence variation in class 1 outer membrane protein in Neisseria meningitidis isolated from patients with meningococcal infection and close household contacts.
FEMS microbiology letters 1995;128(2):145-50.
1995: H de la Paz; S J Cooke; John E Heckels
Effect of sialylation of lipopolysaccharide of Neisseria gonorrhoeae on recognition and complement-mediated killing by monoclonal antibodies directed against different outer-membrane antigens.
Microbiology (Reading, England) 1995;141 ( Pt 4)():913-20.
1994: J L Brooks; Einar Rosenqvist; G Bjune; Paul R Lambden; John E Heckels
Comparison of the class-1 outer membrane protein from B:15:P1.16 Neisseria meningitidis strains isolated from patients previously immunized with a serogroup B outer membrane protein vaccine in Norway.
Microbial pathogenesis 1994;17(6):425-30.
1994: Myron Christodoulides; John E Heckels
Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: production of bactericidal antibodies against group B Neisseria meningitidis.
Microbiology (Reading, England) 1994;140 ( Pt 11)():2951-60.
1994: Alexei von Delwig; S Jahn; Barica Kusecek; John E Heckels; Einar Rosenqvist; E Arne Høiby; Terje E Michaelsen; Mark Achtman
A comparison of human and murine monoclonal IgGs specific for the P1.7 PorA protein of Neisseria meningitidis.
Molecular immunology 1994;31(16):1257-67.
1993: B J Mee; H Thomas; S J Cooke; Paul R Lambden; John E Heckels
Structural comparison and epitope analysis of outer-membrane protein PIA from strains of Neisseria gonorrhoeae with differing serovar specificities.
Journal of general microbiology 1993;139(11):2613-20.
1993: Einar Rosenqvist; E Arne Høiby; Elisabeth Wedege; Dominique A Caugant; L Oddvar Frøholm; B T McGuinness; J Brooks; Paul R Lambden; John E Heckels
A new variant of serosubtype P1.16 in Neisseria meningitidis from Norway, associated with increased resistance to bactericidal antibodies induced by a serogroup B outer membrane protein vaccine.
Microbial pathogenesis 1993;15(3):197-205.
1993: Myron Christodoulides; B T McGuinness; John E Heckels
Immunization with synthetic peptides containing epitopes of the class 1 outer-membrane protein of Neisseria meningitidis: production of bactericidal antibodies on immunization with a cyclic peptide.
Journal of general microbiology 1993;139(8):1729-38.
1993: B T McGuinness; Paul R Lambden; John E Heckels
Class 1 outer membrane protein of Neisseria meningitidis: epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology.
Molecular microbiology 1993;7(4):505-14.
1992: C R Tinsley; M Virji; John E Heckels
Antibodies recognizing a variety of different structural motifs on meningococcal Lip antigen fail to demonstrate bactericidal activity.
Journal of general microbiology 1992;138(11):2321-8.
1992: M J Ward; Paul R Lambden; John E Heckels
Sequence analysis and relationships between meningococcal class 3 serotype proteins and other porins from pathogenic and non-pathogenic Neisseria species.
FEMS microbiology letters 1992;73(3):283-9.
1991: A Munkley; C R Tinsley; M Virji; John E Heckels
Blocking of bactericidal killing of Neisseria meningitidis by antibodies directed against class 4 outer membrane protein.
Microbial pathogenesis 1991;11(6):447-52.
1991: B T McGuinness; Ian Clarke; Paul R Lambden; A K Barlow; J T Poolman; D M Jones; John E Heckels
Point mutation in meningococcal por A gene associated with increased endemic disease.
Lancet 1991;337(8740):514-7.
1990: N J Butt; M Virji; F Vayreda; Paul R Lambden; John E Heckels
Gonococcal outer-membrane protein PIB: comparative sequence analysis and localization of epitopes which are recognized by type-specific and cross-reacting monoclonal antibodies.
Journal of general microbiology 1990;136(11):2165-72.
1990: N J Butt; Paul R Lambden; John E Heckels
The nucleotide sequence of the por gene from Neisseria gonorrhoeae strain P9 encoding outer membrane protein PIB.
Nucleic acids research 1990;18(14):4258.
1990: John E Heckels; M Virji; C R Tinsley
Vaccination against gonorrhoea: the potential protective effect of immunization with a synthetic peptide containing a conserved epitope of gonococcal outer membrane protein IB.
Vaccine 1990;8(3):225-30.
1990: B McGuinness; A K Barlow; Ian Clarke; J E Farley; A Anilionis; J T Poolman; John E Heckels
Deduced amino acid sequences of class 1 protein (PorA) from three strains of Neisseria meningitidis. Synthetic peptides define the epitopes responsible for serosubtype specificity.
The Journal of experimental medicine 1990;171(6):1871-82.
1990: D A White; A K Barlow; Ian Clarke; John E Heckels
Stable expression of meningococcal class 1 protein in an antigenically reactive form in outer membranes of Escherichia coli.
Molecular microbiology 1990;4(5):769-76.
1989: M Virji; John E Heckels; W J Potts; C Anthony Hart; J R Saunders
Identification of epitopes recognized by monoclonal antibodies SM1 and SM2 which react with all pili of Neisseria gonorrhoeae but which differentiate between two structural classes of pili expressed by Neisseria meningitidis and the distribution of their encoding sequences in the genomes of Neisseria spp.
Journal of general microbiology 1989;135(12):3239-51.
1989: John E Heckels; J N Fletcher; M Virji
The potential protective effect of immunization with outer-membrane protein I from Neisseria gonorrhoeae.
Journal of general microbiology 1989;135(8):2269-76.
1989: M Virji; John E Heckels
Location of a blocking epitope on outer-membrane protein III of Neisseria gonorrhoeae by synthetic peptide analysis.
Journal of general microbiology 1989;135(7):1895-9.
1989: John E Heckels
Structure and function of pili of pathogenic Neisseria species.
Clinical microbiology reviews 1989;2 Suppl():S66-73.
1989: A K Barlow; John E Heckels; Ian Clarke
The class 1 outer membrane protein of Neisseria meningitidis: gene sequence and structural and immunological similarities to gonococcal porins.
Molecular microbiology 1989;3(2):131-9.
1988: M Virji; John E Heckels
Nonbactericidal antibodies against Neisseria gonorrhoeae: evaluation of their blocking effect on bactericidal antibodies directed against outer membrane antigens.
Journal of general microbiology 1988;134(10):2703-11.
1988: A K Barlow; John E Heckels; Ian Clarke
Molecular cloning and expression of Neisseria meningitidis class 1 outer-membrane protein in Escherichia coli K-12.
Journal of medical microbiology 1988;26(3):180-3.
1987: M Virji; K Zak; John E Heckels
Outer membrane protein III of Neisseria gonorrhoeae: variations in biological properties of antibodies directed against different epitopes.
Journal of general microbiology 1987;133(12):3393-401.
1987: A K Barlow; John E Heckels; Ian Clarke
Molecular cloning and expression of Neisseria meningitidis class 1 outer membrane protein in Escherichia coli K-12.
Infection and immunity 1987;55(11):2734-40.
1987: M Virji; J N Fletcher; K Zak; John E Heckels
The potential protective effect of monoclonal antibodies to gonococcal outer membrane protein IA.
Journal of general microbiology 1987;133(9):2639-46.
1987: John E Heckels; M Virji; K Zak; J N Fletcher
Immunobiology of gonococcal outer membrane protein I.
Antonie van Leeuwenhoek 1987;53(6):461-4.
1986: C R Tinsley; John E Heckels
Variation in the expression of pili and outer membrane protein by Neisseria meningitidis during the course of meningococcal infection.
Journal of general microbiology 1986;132(9):2483-90.
1986: M Virji; K Zak; John E Heckels
Monoclonal antibodies to gonococcal outer membrane protein IB: use in investigation of the potential protective effect of antibodies directed against conserved and type-specific epitopes.
Journal of general microbiology 1986;132(6):1621-9.
1986: J N Fletcher; K Zak; M Virji; John E Heckels
Monoclonal antibodies to gonococcal outer membrane protein I: location of a conserved epitope on protein IB.
Journal of general microbiology 1986;132(6):1611-20.
1984: K Zak; J L Diaz; D Jackson; John E Heckels
Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea.
The Journal of infectious diseases 1984;149(2):166-74.
1983: M Virji; John E Heckels; P J Watt
Monoclonal antibodies to gonococcal pili: studies on antigenic determinants on pili from variants of strain P9.
Journal of general microbiology 1983;129(6):1965-73.
1983: M Duckworth; D Jackson; K Zak; John E Heckels
Structural variations in pili expressed during gonococcal infection.
Journal of general microbiology 1983;129(5):1593-6.
1982: Paul R Lambden; John E Heckels; P J Watt
Effect of anti-pilus antibodies on survival of gonococci within guinea pig subcutaneous chambers.
Infection and immunity 1982;38(1):27-30.
1982: J L Diaz; John E Heckels
Antigenic variation of outer membrane protein II in colonial variants of Neisseria gonorrhoeae P9.
Journal of general microbiology 1982;128(3):585-91.
1981: H M McBride; Paul R Lambden; John E Heckels; P J Watt
The role of outer membrane proteins in the survival of Neisseria gonorrhoeae P9 within guinea-pig subcutaneous chambers.
Journal of general microbiology 1981;126(1):63-7.