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E Hecker

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TOP 3
Kathrin Schlatterer; Richard Gminski; Joerg C. Schlatterer; E Hecker; Prakash Chandra; B Schlatterer; G Krauter; Angelika Chandra
12-O-retinoylphorbol-13-acetate (RPA) behaves like a retinoid-derivative in binding to retinol-binding-protein: a correlation with its specific action as an incomplete tumor promoter?
S M A D Zayed; M Farghaly; S M Soliman; H Gotta; B Sorg; E Hecker
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). V. Skin irriitant and tumor-promoting diterpene ester toxins of the tigliane and ingenane type in the herbs Euphorbia nubica and Euphorbia helioscopia contaminating fodder of livestock.
M Nawito; Y F Ahmed; S I Shalaby; A Nada; S M A D Zayed; E Hecker
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Euphorbia nubica and Euphorbia helioscopia: an etiologic model for investigations on the putative risk of cancer by consumption of food p.

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All Publications

2005: Kathrin Schlatterer; Richard Gminski; Joerg C. Schlatterer; E Hecker; Prakash Chandra; B Schlatterer; G Krauter; Angelika Chandra
12-O-retinoylphorbol-13-acetate (RPA) behaves like a retinoid-derivative in binding to retinol-binding-protein: a correlation with its specific action as an incomplete tumor promoter?
Anticancer research 2005;25(5):3355-65.
2001: S M A D Zayed; M Farghaly; S M Soliman; H Gotta; B Sorg; E Hecker
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). V. Skin irriitant and tumor-promoting diterpene ester toxins of the tigliane and ingenane type in the herbs Euphorbia nubica and Euphorbia helioscopia contaminating fodder of livestock.
Journal of cancer research and clinical oncology 2001;127(1):40-7.
2001: M Nawito; Y F Ahmed; S I Shalaby; A Nada; S M A D Zayed; E Hecker
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Euphorbia nubica and Euphorbia helioscopia: an etiologic model for investigations on the putative risk of cancer by consumption of food p.
Journal of cancer research and clinical oncology 2001;127(1):34-9.
2000: Kathrin Schlatterer; B Schlatterer; G Krauter; E Hecker; Prakash Chandra
A novel polypeptide p10 expressed in tumor-promoter-treated murine epidermis and in untreated neonatal murine epidermis.
Anticancer research 2000;20(1A):289-92.
1999: Kathrin Schlatterer; G Krauter; B Schlatterer; E Hecker; Prakash Chandra
A novel protein (p10) induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and other hyperplasiogenic tumor-promoting and non-promoting agents in murine epidermis.
Anticancer research 1999;19(1A):397-402.
1999: Kathrin Schlatterer; G Krauter; B Schlatterer; E Hecker; Prakash Chandra
Mechanistically different acting tumor promoters induce consistent qualitative and quantitative changes in protein expression patterns of murine epidermis.
Anticancer research 1999;19(1A):385-95.
1998: S M A D Zayed; M Farghaly; H Taha; Richard Gminski; E Hecker
Dietary cancer risk from conditional cancerogens in produce of livestock fed on species of spurge (Euphorbiaceae). III. Milk of lactating goats fed on the skin irritant herb Euphorbia peplus is polluted by tumor promoters of the ingenane diterpene ester type.
Journal of cancer research and clinical oncology 1998;124(6):301-6.
1998: M Nawito; Y F Ahmed; S M A D Zayed; E Hecker
Dietary cancer risk from conditional cancerogens in produce of livestock fed on species of spurge (Euphorbiaceae). II. Pathophysiological investigations in lactating goats fed on the skin irritant herb Euphorbia peplus and in their milk-raised kids.
Journal of cancer research and clinical oncology 1998;124(3-4):179-85.
1998: S M A D Zayed; M Farghaly; H Taha; H Gotta; E Hecker
Dietary cancer risk conditional cancerogens in produce of livestock fed on species of spurge (Euphorbiaceae). I. Skin irritant and tumor-promoting ingenane-type diterpene esters in E. peplus, one of several herbaceous Euphorbia species contaminating fodder of livestock.
Journal of cancer research and clinical oncology 1998;124(3-4):131-40.
1996: G Krauter; Claus-W von der Lieth; R Schmidt; E Hecker
Structure/activity relationships of polyfunctional diterpenes of the tigliane type. A pharmacophore model for protein-kinase-C activators based on structure/activity studies and molecular modeling of the tumor promoters 12-O-tetradecanoylphorbol 13-acetate and 3-O-tetradecanoylingenol.
European journal of biochemistry / FEBS 1996;242(2):417-27.
1995: J Svetek; Milan Schara; Slavko Pecar; Manfred Hergenhahn; E Hecker
Spectroscopic characterization of specific phorbol ester binding to PKC-receptor sites in membranes in situ.
Carcinogenesis 1995;16(10):2589-92.
1994: C Karalai; P Wiriyachitra; B Sorg; E Hecker
Improved access to highly unsaturated skin irritants of the daphnane type from latex of Excoecaria oppositifolia.
Planta medica 1994;60(6):566-8.
1994: C Karalai; P Wiriyachitra; H J Opferkuch; E Hecker
Cryptic and free skin irritants of the daphnane and tigliane types in latex of Excoecaria agallocha.
Planta medica 1994;60(4):351-5.
1992: J Svetek; Manfred Hergenhahn; Milan Schara; Slavko Pecar; E Hecker
Spin-labeled phorbol esters and their interactions with cellular membranes--V. Electron paramagnetic resonance of spin-labeled phorbol-12,13-diesters bound to their receptors in mouse brain particulate fraction.
Carcinogenesis 1992;13(2):211-6.
1992: Slavko Pecar; Milan Schara; M Nemec; E Hecker
Spin-labeled phorbol esters and their interactions with cellular membranes--IV. Lipophilic binding and molecular orientation of spin-labeled phorbol-12,13-diesters in human erythrocyte membrane.
Carcinogenesis 1992;13(2):205-9.
1992: S Brøgger Christensen; Manfred Hergenhahn; H Roeser; E Hecker
Toxicodynamics of tumour promoters of mouse skin. III. Specific binding of the tumour promoter thapsigargin as measured by the cold-acetone filter assay.
Journal of cancer research and clinical oncology 1992;118(5):344-8.
1991: H Roeser; T Doege; E Hecker
Toxicokinetics of tumour promoters of mouse skin. II. Metabolism of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin and biological activities of metabolites.
Carcinogenesis 1991;12(9):1563-70.
1991: L Edler; R Schmidt; E Weber; Friedrich Rippmann; E Hecker
Biological assays for irritant, tumor-initiating and -promoting activities. III. Computer-assisted management and validation of biodata generated by standardized initiation/promotion protocols in skin of mice.
Journal of cancer research and clinical oncology 1991;117(3):205-16.
1991: Manfred Hergenhahn; U Kloz; M Fellhauer; G L Tremp; E Hecker
Toxicodynamics of tumour promoters of mouse skin. II. Binding to protein kinase C of some new diterpene esters and induction of luminol-enhanced chemoluminescence in mouse peritoneal neutrophils.
Journal of cancer research and clinical oncology 1991;117(5):385-95.
1990: G Müller; Manfred Hergenhahn; H Roeser; G L Tremp; R Schmidt; E Hecker
Toxicokinetics of tumor promoters of mouse skin. I. Metabolism of phorbol and ingenol esters by mouse liver microsomes.
Carcinogenesis 1990;11(7):1127-32.
1989: U Kloz; Manfred Hergenhahn; M Fellhauer; E Hecker
Induction of Epstein-Barr virus early antigens by tumor promoters of the diterpene ester type in Raji cells and specific (receptor) binding as compared to irritant and promoting activities.
Journal of cancer research and clinical oncology 1989;115(2):148-56.
1989: R Schmidt; E Hecker
Biological assays for irritant, tumor-initiating and tumor-promoting activities. II. Standardized initiation/promotion protocol and semiquantitative estimation of promoting (or initiating) potencies in skin of NMRI mice.
Journal of cancer research and clinical oncology 1989;115(6):516-24.
1988: S Sosath; H H Ott; E Hecker
Irritant principles of the spurge family (Euphorbiaceae). XIII. Oligocyclic and macrocyclic diterpene esters from latices of some Euphorbia species utilized as source plants of honey.
Journal of natural products 1988;51(6):1062-74.
1988: B Sorg; R Schmidt; Slavko Pecar; Milan Schara; E Hecker
Spin-labeled phorbol esters and their interactions with cellular membranes. III. Skin irritant and tumor-promoting activities of spin-labeled phorbol-12,13-diesters and relationships to their particular structures.
Carcinogenesis 1988;9(10):1829-34.
1988: W Adolf; E H Seip; E Hecker; S F Dossaji
Irritant principles of the mezereon family (Thymelaeaceae), V. New skin irritants and tumor promoters of the daphnane and 1 alpha-alkyldaphnane type from Synaptolepis kirkii and Synaptolepis retusa.
Journal of natural products 1988;51(4):662-74.
1985: P Wiriyachitra; H Hajiwangoh; P Boonton; W Adolf; H J Opferkuch; E Hecker
Investigations of medicinal plants of euphorbiaceae and thymelaeaceae occurring and used in Thailand; II. Cryptic irritants of the diterpene ester type from three Excoecaria species.
Planta medica 1985;(5):368-71.
1985: G L Tremp; E Hecker
Stability of the "second stage" promoter 12-O-retinoylphorbol-13-acetate.
Cancer research 1985;45(5):2390-1.
1984: W Adolf; E Hecker; H Becker
Macrocyclic lathyrane type diterpene esters (jolkinols) from callus cultures and roots of Euphorbia lathyris.
Planta medica 1984;50(3):259-61.
1984: W Adolf; E Hecker
On the active principles of the spurge family, X. Skin irritants, cocarcinogens, and cryptic cocarcinogens from the latex of the manchineel tree.
Journal of natural products 1984;47(3):482-96.
1984: S M A D Zayed; B Sorg; E Hecker
Structure activity relations of polyfunctional diterpenes of the tigliane type, VI. Irritant and tumor promoting activities of semisynthetic mono and diesters of 12-deoxyphorbol.
Planta medica 1984;50(1):65-9.
1984: Manfred Hergenhahn; S Kusumoto; E Hecker
On the active principles of the spurge family (Euphorbiaceae). V. Extremely skin-irritant and moderately tumor-promoting diterpene esters from Euphorbia resinifera Berg.
Journal of cancer research and clinical oncology 1984;108(1):98-109.
1984: Manfred Hergenhahn; E Hecker
Specific lipid components in membrane receptors of 12-O-tetradecanoylphorbol-13-acetate as revealed by direct photoaffinity labelling.
IARC scientific publications 1984;(56):165-75.
1983: E H Seip; H H Ott; E Hecker
Skin irritant and tumor promoting diterpene esters of the tigliane type from the Chinese tallow tree (Sapium sebiferum).
Planta medica 1983;49(4):199-203.
1983: A Hafez; W Adolf; E Hecker
Active principles of the thymelaeaceae. III. Skin irritant and cocarcinogenic factors from Pimelea simplex.
Planta medica 1983;49(1):3-8.
1983: R Schmidt; W Adolf; A Marston; H Roeser; B Sorg; H Fujiki; T Sugimura; R E Moore; E Hecker
Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin.
Carcinogenesis 1983;4(1):77-81.
1983: E Hecker; W Adolf; Manfred Hergenhahn; R Schmidt; B Sorg
Irritant diterpene ester promoters of mouse skin: contributions to etiologies of environmental cancer and to biochemical mechanisms of carcinogenesis.
Princess Takamatsu symposia 1983;14():3-36.
1982: E H Seip; E Hecker
Skin irritant ingenol esters from Euphorbia esula.
Planta medica 1982;46(4):215-8.
1982: W Adolf; E Hecker
On the active principles of the Thymelaeaceae. II. Skin irritant and cocarcinogenic diterpenoid factors from Daphnopsis racemosa.
Planta medica 1982;45(3):177-82.
1982: S M A D Zayed; W Adolf; E Hecker
On the active principles of the Thymelaeaceae. I. The irritants and cocarcinogens of Pimelea prostrata.
Planta medica 1982;45(2):67-77.
1982: W Adolf; B Sorg; Manfred Hergenhahn; E Hecker
Structure-activity relations of polyfunctional diterpenes of the daphnane type. I. Revised structure for resiniferatoxin and structure-activity relations of resiniferonol and some of its esters.
Journal of natural products 1982;45(3):347-54.
1982: Manfred Hergenhahn; G Fürstenberger; H J Opferkuch; W Adolf; H Mack; E Hecker
Biological assays for irritant tumor-initiating and -promoting activities. I. Kinetics of the irritant response in relation to the initiation-promoting activity of polyfunctional diterpenes representing tigliane and some daphnane types.
Journal of cancer research and clinical oncology 1982;104(1-2):31-9.
1982: H J Opferkuch; E Hecker
On the active principles of the spurge family (Euphorbiaceae). IV. Skin irritant and tumor promoting diterpene esters from Euphorbia ingens E.Mey.
Journal of cancer research and clinical oncology 1982;103(3):255-68.
1982: R Keller; R Keist; W Adolf; H J Opferkuch; R Schmidt; E Hecker
Tumor-promoting diterpene esters prevent macrophage activation and suppress macrophage tumoricidal capacity.
Experimental cell biology 1982;50(3):121-34.
1982: W Adolf; S M A D Zayed; E Hecker
New, most active 1 alpha-alkyldaphnane-type irritants and tumor promoters from species of the Thymelaeaceae.
Carcinogenesis; a comprehensive survey 1982;7():49-55.
1982: M Nakayasu; M Terada; W Adolf; H J Opferkuch; R Schmidt; E Hecker; T Sugimura
Induction of differentiation in human promyelocytic leukemia cells by tumor promoters.
Journal of cancer research and clinical oncology 1982;103(1):17-29.
1982: Slavko Pecar; Marjeta Sentjurc; Milan Schara; M Nemec; B Sorg; E Hecker
Spin-labeled phorbol esters and their interaction with cellular membranes.
Carcinogenesis; a comprehensive survey 1982;7():541-53.
1981: Manfred Hergenhahn; E Hecker
Specific binding of the tumor promoter TPA in various mouse organs as measured by a "cold acetone-filter assay'.
Carcinogenesis 1981;2(12):1277-81.