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Yacov Ashani

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Israel Silman; Joel L Sussman; Mathilde M Triquigneaux; Yacov Ashani; Leesa J Deterding; Marilyn Ehrenshaft; Ronald P Mason; Aviv Paz; Esther Roth; Valery L Shnyrov; Yechun Xu; Lev Weiner
The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.
Aviv Paz; Esther Roth; Valery L Shnyrov; Israel Silman; Joel L Sussman; Yacov Ashani; Yechun Xu; Lev Weiner
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.
Moshe Goldsmith; Haim Leader; Israel Silman; Yair Simo; Joel L Sussman; Yacov Ashani; Moshe Ben-David; Dan S Tawfik
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.

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All Publications

2013: Israel Silman; Joel L Sussman; Mathilde M Triquigneaux; Yacov Ashani; Leesa J Deterding; Marilyn Ehrenshaft; Ronald P Mason; Aviv Paz; Esther Roth; Valery L Shnyrov; Yechun Xu; Lev Weiner
The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.
Chemico-biological interactions 2013;203(1):63-6.
2012: Aviv Paz; Esther Roth; Valery L Shnyrov; Israel Silman; Joel L Sussman; Yacov Ashani; Yechun Xu; Lev Weiner
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.
Protein science : a publication of the Protein Society 2012;21(8):1138-52.
2012: Moshe Goldsmith; Haim Leader; Israel Silman; Yair Simo; Joel L Sussman; Yacov Ashani; Moshe Ben-David; Dan S Tawfik
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.
Chemistry & biology 2012;19(4):456-66.
2012: Sagar D Khare; Yakov Kipnis; Haim Leader; Israel Silman; Yifan Song; Barry L Stoddard; Joel L Sussman; Ryo Takeuchi; Dan S Tawfik; Yacov Ashani; Jasmine L Gallaher; Moshe Goldsmith; Per Greisen; David Baker
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nature chemical biology 2012;8(3):294-300.
2011: Yacov Ashani; Moshe Goldsmith; Haim Leader; Israel Silman; Joel L Sussman; Dan S Tawfik
In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.
Toxicology letters 2011;206(1):24-8.
2011: Rinkoo Gupta; Moshe Goldsmith; Yacov Ashani; Yair Simo; Gavriel Mullokandov; Hagit Bar; Moshe Ben-David; Haim Leader; Raanan Margalit; Israel Silman; Joel L Sussman; Dan S Tawfik
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
Nature chemical biology 2011;7(2):120-5.
2010: Yacov Ashani; Rinkoo Gupta; M Goldsmith; Israel Silman; Joel Sussman; Dan S Tawfik; H Leader
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.
Chemico-biological interactions 2010;187(1-3):362-9.
2009: Oz Sharabi; Yoav Peleg; Efrat Mashiach; Eyal Vardy; Yacov Ashani; Israel Silman; Joel Sussman; Julia M Shifman
Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.
Protein engineering, design & selection : PEDS 2009;22(10):641-8.
2009: Lev Weiner; Valery L Shnyrov; Leonid Konstantinovskii; Esther Roth; Yacov Ashani; Israel Silman
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.
Biochemistry 2009;48(3):563-74.
2007: Efrat Groner; Yacov Ashani; Donna Schorer-Apelbaum; Jeffrey Sterling; Yaacov Herzig; Marta Weinstock
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates.
Molecular pharmacology 2007;71(6):1610-7.
2005: Omri Segev; Ishay Columbus; Yacov Ashani; Yoram Cohen
Probing the molecular interaction of chymotrypsin with organophosphorus compounds by 31P diffusion NMR in aqueous solutions.
The Journal of organic chemistry 2005;70(1):309-14.
2004: D Waysbort; E Manisterski; Haim Leader; B Manisterski; Yacov Ashani
Laboratory setup for long-term monitoring of the volatilization of hazardous materials: preliminary tests of O-ethyl S-2-(N,N-diisopropylamino)ethyl methylphosphonothiolate on asphalt.
Environmental science & technology 2004;38(7):2217-23.
2004: Yacov Ashani; Shlomi Pistinner
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(2):358-67.
2004: Yacov Ashani; Omri Segev; Ayala Balan
The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma.
Toxicology and applied pharmacology 2004;194(1):90-9.
2003: Yacov Ashani; Apurba K Bhattacharjee; Haim Leader; Ashima Saxena; Bhupendra P Doctor
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.
Biochemical pharmacology 2003;66(2):191-202.
2002: Yvonne Rosenberg; Chunyuan Luo; Yacov Ashani; Bhupendra P Doctor; Randy Fischer; Gary Wolfe; Ashima Saxena
Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase.
Life sciences 2002;72(2):125-34.
1999: Haim Leader; A Vincze; B Manisterski; N Rothschild; Carlos G Dosoretz; Yacov Ashani
Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases.
Biochemical pharmacology 1999;58(3):503-15.
1999: Chunyuan Luo; Ashima Saxena; Yacov Ashani; Haim Leader; Z Radić; Palmer Taylor; Bhupendra P Doctor
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.
Chemico-biological interactions 1999;119-120():129-35.
1998: N Allon; Lily Raveh; Eran Gilat; E Cohen; J Grunwald; Yacov Ashani
Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase.
Toxicological sciences : an official journal of the Society of Toxicology 1998;43(2):121-8.
1998: Chunyuan Luo; Yacov Ashani; Bhupendra P Doctor
Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands.
Molecular pharmacology 1998;53(4):718-26.
1998: Yacov Ashani; Haim Leader; N Rothschild; Carlos G Dosoretz
Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates.
Biochemical pharmacology 1998;55(2):159-68.
1998: Ashima Saxena; Yacov Ashani; Lily Raveh; D Stevenson; T Patel; Bhupendra P Doctor
Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases.
Molecular pharmacology 1998;53(1):112-22.
1997: Lily Raveh; Grauer Ettie; J Grunwald; E Cohen; Yacov Ashani
The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase.
Toxicology and applied pharmacology 1997;145(1):43-53.
1997: Ashima Saxena; Lily Raveh; Yacov Ashani; Bhupendra P Doctor
Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase.
Biochemistry 1997;36(24):7481-9.
1997: J Grunwald; D Marcus; Y Papier; Lily Raveh; Zipora Pittel; Yacov Ashani
Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug.
Journal of biochemical and biophysical methods 1997;34(2):123-35.
1995: Yacov Ashani; Z Radić; Igor Tsigelny; D C Vellom; N A Pickering; Daniel M Quinn; Bhupendra P Doctor; Palmer Taylor
Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.
The Journal of biological chemistry 1995;270(11):6370-80.
1995: M K Gentry; D R Moorad; R S Hur; Ashima Saxena; Yacov Ashani; Bhupendra P Doctor
Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases.
Journal of neurochemistry 1995;64(2):842-9.
1994: Yacov Ashani; J Grunwald; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Molecular pharmacology 1994;45(3):555-60.
1994: G R Caranto; K H Waibel; J M Asher; R W Larrison; K M Brecht; M B Schutz; Lily Raveh; Yacov Ashani; A D Wolfe; Donald M Maxwell
Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes.
Biochemical pharmacology 1994;47(2):347-57.
1994: J Grunwald; Lily Raveh; Bhupendra P Doctor; Yacov Ashani
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Life sciences 1994;54(14):991-7.
1993: Yoffi Segall; D Waysbort; Dov Barak; Naomi Ariel; Bhupendra P Doctor; J Grunwald; Yacov Ashani
Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy.
Biochemistry 1993;32(49):13441-50.
1993: Rachel Brandeis; Lily Raveh; J Grunwald; E Cohen; Yacov Ashani
Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats.
Pharmacology, biochemistry, and behavior 1993;46(4):889-96.
1993: Lily Raveh; J Grunwald; D Marcus; Y Papier; E Cohen; Yacov Ashani
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
Biochemical pharmacology 1993;45(12):2465-74.
1993: M K Gentry; Ashima Saxena; Yacov Ashani; Bhupendra P Doctor
Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies.
Chemico-biological interactions 1993;87(1-3):227-31.
1992: Lily Raveh; Yoffi Segall; Haim Leader; N Rothschild; D Levanon; Y Henis; Yacov Ashani
Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters.
Biochemical pharmacology 1992;44(2):397-400.
1992: Yacov Ashani; J O Peggins; Bhupendra P Doctor
Mechanism of inhibition of cholinesterases by huperzine A.
Biochemical and biophysical research communications 1992;184(2):719-26.
1991: Michal Harel; C T Su; Felix Frolow; Yacov Ashani; Israel Silman; Joel Sussman
Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
Journal of molecular biology 1991;221(3):909-18.
1991: Bhupendra P Doctor; Lily Raveh; A D Wolfe; Donald M Maxwell; Yacov Ashani
Enzymes as pretreatment drugs for organophosphate toxicity.
Neuroscience and biobehavioral reviews 1991;15(1):123-8.
1991: Yacov Ashani; S Shapira; D Levy; A D Wolfe; Bhupendra P Doctor; Lily Raveh
Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice.
Biochemical pharmacology 1991;41(1):37-41.
1991: Yacov Ashani; N Rothschild; Yoffi Segall; D Levanon; Lily Raveh
Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice.
Life sciences 1991;49(5):367-74.
1990: Yacov Ashani; M K Gentry; Bhupendra P Doctor
Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody.
Biochemistry 1990;29(10):2456-63.
1989: J Grunwald; Yoffi Segall; E Shirin; D Waysbort; N Steinberg; Israel Silman; Yacov Ashani
Aged and non-aged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin. Preparation and comparison by 31P-NMR spectroscopy.
Biochemical pharmacology 1989;38(19):3157-68.
1989: N Steinberg; A C van der Drift; J Grunwald; Yoffi Segall; E Shirin; E Haas; Yacov Ashani; Israel Silman
Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy.
Biochemistry 1989;28(3):1248-53.
1989: Lily Raveh; Yacov Ashani; D Levy; D De La Hoz; A D Wolfe; Bhupendra P Doctor
Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice.
Biochemical pharmacology 1989;38(3):529-34.
1989: N Steinberg; J Grunwald; E Roth; R August; E Haas; Yacov Ashani; Israel Silman
Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin.
Progress in clinical and biological research 1989;289():293-304.
1989: Bhupendra P Doctor; K K Smyth; M K Gentry; Yacov Ashani; C E Christner; D M de la Hoz; R A Ogert; S W Smith
Structural and immunochemical properties of fetal bovine serum acetylcholinesterase.
Progress in clinical and biological research 1989;289():305-16.
1988: A Balan; I Barness; G Simon; D Levy; Yacov Ashani
Tritium labeling of a powerful methylphosphonate inhibitor of cholinesterase: synthesis and biological applications.
Analytical biochemistry 1988;169(1):95-103.
1986: E Heldman; Yacov Ashani; Lily Raveh; E S Rachaman
Sugar conjugates of pyridinium aldoximes as antidotes against organophosphate poisoning.
Carbohydrate research 1986;151():337-47.
1985: Tamar Kadar; Lily Raveh; G Cohen; N Oz; I Baranes; A Balan; Yacov Ashani; S Shapira
Distribution of 3H-soman in mice.
Archives of toxicology 1985;58(1):45-9.
1985: Yacov Ashani; D Levy; E Heyman; Y Grunfeld; Tamar Kadar; M Spiegelstein
A quaternary anti-cholinesterase probe for determining the integrity of the blood--brain barrier.
Life sciences 1985;36(5):493-7.
1983: Yacov Ashani; Haim Leader; Lily Raveh; R Bruckstein; M Spiegelstein
In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.
Journal of medicinal chemistry 1983;26(2):145-52.
1980: G Amitai; Yacov Ashani; A Gafni; Israel Silman
New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase.
Neurochemistry international 1980;2C():199-204.