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Yacov Ashani

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Poisoning

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Co-Publications
Name
17
Doctor, Bhupendra
17
Raveh, Lily
7
Leader, Haim
6
Saxena, Ashima
5
Segall, Yoffi
4
Silman, Israel
4
Rothschild, N
3
Grunwald, J
2
Kadar, Tamar
2
Luo, Chunyuan
2
Maxwell, Donald
2
Dosoretz, Carlos
2
Taylor, Palmer
2
Radic, Zoran
1
Tsigelny, Igor

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Publications

TOP 3
Sharabi Oz; Peleg Yoav; Mashiach Efrat; Vardy Eyal; Ashani Yacov; Silman Israel; Sussman Joel L; Shifman Julia M
Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.
Weiner Lev; Shnyrov Valery L; Konstantinovskii Leonid; Roth Esther; Ashani Yacov; Silman Israel
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.
Groner Efrat; Ashani Yacov; Schorer-Apelbaum Donna; Sterling Jeffrey; Herzig Yaacov; Weinstock Marta
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates.

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All Publications

2009: Sharabi Oz; Peleg Yoav; Mashiach Efrat; Vardy Eyal; Ashani Yacov; Silman Israel; Sussman Joel L; Shifman Julia M
Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.
Protein engineering, design & selection : PEDS 2009;22(10):641-8.
2009: Weiner Lev; Shnyrov Valery L; Konstantinovskii Leonid; Roth Esther; Ashani Yacov; Silman Israel
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.
Biochemistry 2009;48(3):563-74.
2007: Groner Efrat; Ashani Yacov; Schorer-Apelbaum Donna; Sterling Jeffrey; Herzig Yaacov; Weinstock Marta
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates.
Molecular pharmacology 2007;71(6):1610-7.
2005: Segev Omri; Columbus Ishay; Ashani Yacov; Cohen Yoram
Probing the molecular interaction of chymotrypsin with organophosphorus compounds by 31P diffusion NMR in aqueous solutions.
The Journal of organic chemistry 2005;70(1):309-14.
2004: Waysbort D; Manisterski E; Leader H; Manisterski B; Ashani Y
Laboratory setup for long-term monitoring of the volatilization of hazardous materials: preliminary tests of O-ethyl S-2-(N,N-diisopropylamino)ethyl methylphosphonothiolate on asphalt.
Environmental science & technology 2004;38(7):2217-23.
2004: Ashani Yacov; Pistinner Shlomi
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(2):358-67.
2004: Ashani Yacov; Segev Omri; Balan Ayala
The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma.
Toxicology and applied pharmacology 2004;194(1):90-9.
2003: Ashani Yacov; Bhattacharjee Apurba K; Leader Haim; Saxena Ashima; Doctor Bhupendra P
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.
Biochemical pharmacology 2003;66(2):191-202.
2002: Rosenberg Yvonne; Luo Chunyuan; Ashani Yacov; Doctor Bhupendra P; Fischer Randy; Wolfe Gary; Saxena Ashima
Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase.
Life sciences 2002;72(2):125-34.
1999: Leader H; Vincze A; Manisterski B; Rothschild N; Dosoretz C; Ashani Y
Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases.
Biochemical pharmacology 1999;58(3):503-15.
1999: Luo C; Saxena A; Ashani Y; Leader H; Radic Z; Taylor P; Doctor B P
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.
Chemico-biological interactions 1999;119-120():129-35.
1998: Allon N; Raveh L; Gilat E; Cohen E; Grunwald J; Ashani Y
Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase.
Toxicological sciences : an official journal of the Society of Toxicology 1998;43(2):121-8.
1998: Luo C; Ashani Y; Doctor B P
Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands.
Molecular pharmacology 1998;53(4):718-26.
1998: Ashani Y; Leader H; Rothschild N; Dosoretz C
Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates.
Biochemical pharmacology 1998;55(2):159-68.
1998: Saxena A; Ashani Y; Raveh L; Stevenson D; Patel T; Doctor B P
Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases.
Molecular pharmacology 1998;53(1):112-22.
1997: Raveh L; Grauer E; Grunwald J; Cohen E; Ashani Y
The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase.
Toxicology and applied pharmacology 1997;145(1):43-53.
1997: Saxena A; Raveh L; Ashani Y; Doctor B P
Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase.
Biochemistry 1997;36(24):7481-9.
1997: Grunwald J; Marcus D; Papier Y; Raveh L; Pittel Z; Ashani Y
Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug.
Journal of biochemical and biophysical methods 1997;34(2):123-35.
1995: Ashani Y; Radic Z; Tsigelny I; Vellom D C; Pickering N A; Quinn D M; Doctor B P; Taylor P
Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.
The Journal of biological chemistry 1995;270(11):6370-80.
1995: Gentry M K; Moorad D R; Hur R S; Saxena A; Ashani Y; Doctor B P
Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases.
Journal of neurochemistry 1995;64(2):842-9.
1994: Ashani Y; Grunwald J; Kronman C; Velan B; Shafferman A
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Molecular pharmacology 1994;45(3):555-60.
1994: Caranto G R; Waibel K H; Asher J M; Larrison R W; Brecht K M; Schutz M B; Raveh L; Ashani Y; Wolfe A D; Maxwell D M
Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes.
Biochemical pharmacology 1994;47(2):347-57.
1994: Grunwald J; Raveh L; Doctor B P; Ashani Y
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Life sciences 1994;54(14):991-7.
1993: Brandeis R; Raveh L; Grunwald J; Cohen E; Ashani Y
Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats.
Pharmacology, biochemistry, and behavior 1993;46(4):889-96.
1993: Segall Y; Waysbort D; Barak D; Ariel N; Doctor B P; Grunwald J; Ashani Y
Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy.
Biochemistry 1993;32(49):13441-50.
1993: Raveh L; Grunwald J; Marcus D; Papier Y; Cohen E; Ashani Y
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
Biochemical pharmacology 1993;45(12):2465-74.
1993: Gentry M K; Saxena A; Ashani Y; Doctor B P
Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies.
Chemico-biological interactions 1993;87(1-3):227-31.
1992: Raveh L; Segall Y; Leader H; Rothschild N; Levanon D; Henis Y; Ashani Y
Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters.
Biochemical pharmacology 1992;44(2):397-400.
1992: Ashani Y; Peggins J O; Doctor B P
Mechanism of inhibition of cholinesterases by huperzine A.
Biochemical and biophysical research communications 1992;184(2):719-26.
1991: Harel M; Su C T; Frolow F; Ashani Y; Silman I; Sussman J L
Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
Journal of molecular biology 1991;221(3):909-18.
1991: Ashani Y; Shapira S; Levy D; Wolfe A D; Doctor B P; Raveh L
Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice.
Biochemical pharmacology 1991;41(1):37-41.
1991: Doctor B P; Raveh L; Wolfe A D; Maxwell D M; Ashani Y
Enzymes as pretreatment drugs for organophosphate toxicity.
Neuroscience and biobehavioral reviews 1991;15(1):123-8.
1991: Ashani Y; Rothschild N; Segall Y; Levanon D; Raveh L
Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice.
Life sciences 1991;49(5):367-74.
1990: Ashani Y; Gentry M K; Doctor B P
Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody.
Biochemistry 1990;29(10):2456-63.
1989: Grunwald J; Segall Y; Shirin E; Waysbort D; Steinberg N; Silman I; Ashani Y
Aged and non-aged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin. Preparation and comparison by 31P-NMR spectroscopy.
Biochemical pharmacology 1989;38(19):3157-68.
1989: Raveh L; Ashani Y; Levy D; De La Hoz D; Wolfe A D; Doctor B P
Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice.
Biochemical pharmacology 1989;38(3):529-34.
1989: Steinberg N; van der Drift A C; Grunwald J; Segall Y; Shirin E; Haas E; Ashani Y; Silman I
Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy.
Biochemistry 1989;28(3):1248-53.
1989: Steinberg N; Grunwald J; Roth E; August R; Haas E; Ashani Y; Silman I
Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin.
Progress in clinical and biological research 1989;289():293-304.
1989: Doctor B P; Smyth K K; Gentry M K; Ashani Y; Christner C E; de la Hoz D M; Ogert R A; Smith S W
Structural and immunochemical properties of fetal bovine serum acetylcholinesterase.
Progress in clinical and biological research 1989;289():305-16.
1988: Balan A; Barness I; Simon G; Levy D; Ashani Y
Tritium labeling of a powerful methylphosphonate inhibitor of cholinesterase: synthesis and biological applications.
Analytical biochemistry 1988;169(1):95-103.
1986: Heldman E; Ashani Y; Raveh L; Rachaman E S
Sugar conjugates of pyridinium aldoximes as antidotes against organophosphate poisoning.
Carbohydrate research 1986;151():337-47.
1985: Kadar T; Raveh L; Cohen G; Oz N; Baranes I; Balan A; Ashani Y; Shapira S
Distribution of 3H-soman in mice.
Archives of toxicology 1985;58(1):45-9.
1985: Ashani Y; Levy D; Heyman E; Grunfeld Y; Kadar T; Spiegelstein M
A quaternary anti-cholinesterase probe for determining the integrity of the blood--brain barrier.
Life sciences 1985;36(5):493-7.
1983: Ashani Y; Leader H; Raveh L; Bruckstein R; Spiegelstein M
In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.
Journal of medicinal chemistry 1983;26(2):145-52.

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