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James Heffron

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Catherine McDermott; Maria Hutch O'Donoghue; James J A Heffron
n-Hexane toxicity in Jurkat T-cells is mediated by reactive oxygen species.
Catherine McDermott; Ashley Allshire; F N A M van Pelt; James J A Heffron
In vitro exposure of jurkat T-cells to industrially important organic solvents in binary combination: interaction analysis.
Catherine McDermott; Ashley Allshire; F N A M van Pelt; James J A Heffron
Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro.

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All Publications

2008: Catherine McDermott; Maria Hutch O'Donoghue; James J A Heffron
n-Hexane toxicity in Jurkat T-cells is mediated by reactive oxygen species.
Archives of toxicology 2008;82(3):165-71.
2008: Catherine McDermott; Ashley Allshire; F N A M van Pelt; James J A Heffron
In vitro exposure of jurkat T-cells to industrially important organic solvents in binary combination: interaction analysis.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(2):263-74.
2007: Catherine McDermott; Ashley Allshire; F N A M van Pelt; James J A Heffron
Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro.
Toxicology and applied pharmacology 2007;219(1):85-94.
2007: Catherine McDermott; Ashley Allshire; F N A M van Pelt; James J A Heffron
Validation of a method for acute and subchronic exposure of cells in vitro to volatile organic solvents.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(1):116-24.
2005: Werner Klingler; James J A Heffron; Karin Jurkat-Rott; Grainne O'sullivan; Andreas Alt; Friedrich Schlesinger; Johannes Bufler; Frank Lehmann-Horn
3,4-Methylenedioxymethamphetamine (ecstasy) activates skeletal muscle nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1267-73.
2004: M G J Hartl; Benjamin M Coughlan; David Sheehan; Carmel Mothersill; F N A M van Pelt; S J O'Reilly; James J A Heffron; John O'Halloran; Nora M O'Brien
Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments.
Marine environmental research 2004;57(4):295-310.
2003: Frank Wappler; Martin Anetseder; Christoph Baur; K Censier; S Doetsch; P Felleiter; Marko Fiege; R Fricker; P Jane Halsall; Edmund J Hartung; James J A Heffron; Luc Heytens; Philip M Hopkins; Werner Klingler; Frank Lehmann-Horn; Yves Nivoche; Vincenzo Tegazzin; I Tzanova; Albert Urwyler; Ralf Weisshorn; Jochen Schulte am Esch
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
European journal of anaesthesiology 2003;20(7):528-36.
2001: G H O'Sullivan; J M McIntosh; James J A Heffron
Abnormal uptake and release of Ca2+ ions from human malignant hyperthermia-susceptible sarcoplasmic reticulum.
Biochemical pharmacology 2001;61(12):1479-85.
2000: J M McIntosh; James J A Heffron
Modelling alterations in the partition coefficient in in vitro biological systems using headspace gas chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(2):207-16.
2000: D O'Connell; James J A Heffron
Rapid analysis of illicit drugs by mass spectrometry: results from seizures in Ireland.
The Analyst 2000;125(1):119-21.
2000: Christoph Baur; L Bellon; P Felleiter; Marko Fiege; R Fricker; K Glahn; James J A Heffron; A Herrmann-Frank; Karin Jurkat-Rott; Werner Klingler; M Lehane; H Ording; Vincenzo Tegazzin; Frank Wappler; Michael Georgieff; Frank Lehmann-Horn
A multicenter study of 4-chloro-m-cresol for diagnosing malignant hyperthermia susceptibility.
Anesthesia and analgesia 2000;90(1):200-5.
1999: PJ Lynch; J Tong; M Lehane; A Mallet; LM Giblin; James J A Heffron; Pat Vaughan; G Zafra; David H MacLennan; Tommie V McCarthy
A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):4164-9.
1998: BM Manning; Kathleen A Quane; H Ording; Albert Urwyler; Vincenzo Tegazzin; M Lehane; John O'Halloran; Edmund J Hartung; LM Giblin; PJ Lynch; Pat Vaughan; K Censier; D Bendixen; G Comi; Luc Heytens; Koenraad G Monsieurs; TH Fagerlund; Werner Wolz; James J A Heffron; Clemens R Muller; Tommie V McCarthy
Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation.
American journal of human genetics 1998;62(3):599-609.
1998: J McIntosh; James J A Heffron
In vitro toxicological assessment of mixtures of organic solvents of industrial importance.
Biochemical Society transactions 1998;26(1):S59.
1997: H Ording; Virginia Brancadoro; Santolo Cozzolino; Francis Richard Ellis; V Glauber; E F Gonano; P Jane Halsall; Edmund J Hartung; James J A Heffron; Luc Heytens; Geneviève Kozak-Ribbens; H Kress; Renée Krivosic-Horber; Frank Lehmann-Horn; W Mortier; Yves Nivoche; E Ranklev Twetman; S Sigurdsson; M Snoeck; P Stieglitz; Vincenzo Tegazzin; Albert Urwyler; Frank Wappler
In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyperthermia Group.
Acta anaesthesiologica Scandinavica 1997;41(8):955-66.
1997: K E Keating; LM Giblin; PJ Lynch; Kathleen A Quane; M Lehane; James J A Heffron; Tommie V McCarthy
Detection of a novel mutation in the ryanodine receptor gene in an Irish malignant hyperthermia pedigree: correlation of the IVCT response with the affected and unaffected haplotypes.
Journal of medical genetics 1997;34(4):291-6.
1997: KJ Baylor; James J A Heffron
Molecular modelling of glutathione-isocyanate interaction.
Biochemical Society transactions 1997;25(1):48S.
1997: KJ Baylor; C M Shine; James J A Heffron; J McIntosh
Isocyanate binding to yeast glutathione reductase measured by fluorescence spectroscopy.
Biochemical Society transactions 1997;25(1):47S.
1997: KJ Baylor; J J Horgan; James J A Heffron
The effects of phenylisocyanate on rat liver mitochondria using the oxygen electrode technique.
Biochemical Society transactions 1997;25(1):46S.
1996: K J Baylor; James J A Heffron
Isocyanate inactivation of yeast glutathione reductase & its modulation by oxidised glutathione and NADPH.
Biochemical Society transactions 1996;24(2):325S.
1996: J M Healy; Kathleen A Quane; K E Keating; M Lehane; James J A Heffron; Tommie V McCarthy
Diagnosis of malignant hyperthermia: a comparison of the in vitro contracture test with the molecular genetic diagnosis in a large pedigree.
Journal of medical genetics 1996;33(1):18-24.
1995: Kathleen A Quane; K E Keating; J M Healy; James J A Heffron; M Lehane; Renée Krivosic-Horber; Luc Heytens; Tommie V McCarthy
Haplotype analysis of the BYR1 gene in malignant hyperthermia and central core disease.
Biochemical Society transactions 1995;23(2):372S.
1995: J McIntosh; James J A Heffron
Perturbations in the cytosolic free calcium ion concentration in isolated cells exposed to certain organic atmospheric pollutants.
Biochemical Society transactions 1995;23(2):361S.
1995: G H O'Sullivan; James J A Heffron
Regulation of Ca2+ release from the ryanodine receptor of sarcoplasmic reticulum.
Biochemical Society transactions 1995;23(2):358S.
1994: K E Keating; Kathleen A Quane; B M Manning; M Lehane; Edmund J Hartung; K Censier; Albert Urwyler; M Klausnitzer; C R Muller; James J A Heffron
Detection of a novel RYR1 mutation in four malignant hyperthermia pedigrees.
Human molecular genetics 1994;3(10):1855-8.
1994: Kathleen A Quane; K E Keating; B M Manning; J M Healy; Koenraad G Monsieurs; James J A Heffron; M Lehane; Luc Heytens; Renée Krivosic-Horber; Pascal Adnet
Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies.
Human molecular genetics 1994;3(3):471-6.
1991: S J Healy; James J A Heffron; M Lehane; D G Bradley; K Johnson; Tommie V McCarthy
Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers.
BMJ (Clinical research ed.) 1991;303(6812):1225-8.
1991: J French; James J A Heffron
Kinetic analysis of halothane induced Ca2+ release from isolated heavy sarcoplasmic reticulum.
Biochemical Society transactions 1991;19(4):355S.
1991: Luc Heytens; James J A Heffron; F Camu
The caffeine contracture test for malignant hyperthermia: caffeine citrate, caffeine benzoate or caffeine free base?
Acta anaesthesiologica Scandinavica 1991;35(6):541-4.
1991: C M Gillian; James J A Heffron; M Lehane; A Marks; Tommie V McCarthy
Analysis of expression of the human ryanodine receptor gene in malignant hyperthermia skeletal muscle tissue.
Biochemical Society transactions 1991;19(1):46S.
1990: J M Healy; M Lehane; James J A Heffron; M Farrell; K Johnson; Tommie V McCarthy
Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-q13.2.
Biochemical Society transactions 1990;18(2):326.
1990: K M Barry; James J A Heffron
Halothane-induced Ca2+ release from heavy sarcoplasmic reticulum.
Biochemical Society transactions 1990;18(2):357-8.
1990: Tommie V McCarthy; J M Healy; James J A Heffron; M Lehane; T Deufel; F Lehmann-Horn; M Farrall; K Johnson
Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2.
Nature 1990;343(6258):562-4.
1990: James J A Heffron; Tommie V McCarthy
Current views of the molecular basis of the malignant hyperthermia syndrome.
Acta anaesthesiologica Belgica 1990;41(2):73-8.
1990: D M McSweeney; James J A Heffron
Uptake and release of calcium ions by heavy sarcoplasmic reticulum fraction of normal and malignant hyperthermia-susceptible human skeletal muscle.
The International journal of biochemistry 1990;22(4):329-33.
1990: Tommie V McCarthy; J M Healy; M Lehane; James J A Heffron
Recent developments in the molecular genetics of malignant hyperthermia: implications for future diagnosis at the DNA level.
Acta anaesthesiologica Belgica 1990;41(2):107-12.
1988: James J A Heffron
Monitoring and assessment of a research student's project.
Biochemical Society transactions 1988;16(2):118-20.
1988: James J A Heffron
Malignant hyperthermia: biochemical aspects of the acute episode.
British journal of anaesthesia 1988;60(3):274-8.