Robert Heflich

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Miura Daishiro; Dobrovolsky Vasily N; Kimoto Takafumi; Kasahara Yoshinori; Heflich Robert H
Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.
Elespuru Rosalie K; Agarwal Rajiv; Atrakchi Aisar H; Bigger C Anita H; Heflich Robert H; Jagannath Devaraya R; Levy Dan D; Moore Martha M; Ouyang Yanli; Robison Timothy W; Sotomayor Rene E; Cimino Michael C; Dearfield Kerry L
Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays.
Von Tungeln Linda S; Churchwell Mona I; Doerge Daniel R; Shaddock Joseph G; McGarrity Lynda J; Heflich Robert H; da Costa Gonçalo Gamboa; Marques M Matilde; Beland Frederick A
DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.

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All Publications

2009: Miura Daishiro; Dobrovolsky Vasily N; Kimoto Takafumi; Kasahara Yoshinori; Heflich Robert H
Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.
Mutation research 2009;677(1-2):86-92.
2009: Elespuru Rosalie K; Agarwal Rajiv; Atrakchi Aisar H; Bigger C Anita H; Heflich Robert H; Jagannath Devaraya R; Levy Dan D; Moore Martha M; Ouyang Yanli; Robison Timothy W; Sotomayor Rene E; Cimino Michael C; Dearfield Kerry L
Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(2):172-9.
2009: Von Tungeln Linda S; Churchwell Mona I; Doerge Daniel R; Shaddock Joseph G; McGarrity Lynda J; Heflich Robert H; da Costa Gonçalo Gamboa; Marques M Matilde; Beland Frederick A
DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.
International journal of cancer. Journal international du cancer 2009;124(9):2006-15.
2008: Miura Daishiro; Dobrovolsky Vasily N; Kasahara Yoshinori; Katsuura Yasuhiro; Heflich Robert H
Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat.
Environmental and molecular mutagenesis 2008;49(8):614-21.
2008: Miura Daishiro; Dobrovolsky Vasily N; Mittelstaedt Roberta A; Kasahara Yoshinori; Katsuura Yasuhiro; Heflich Robert H
Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants.
Environmental and molecular mutagenesis 2008;49(8):622-30.
2008: Moore Martha M; Heflich Robert H; Haber Lynne T; Allen Bruce C; Shipp Annette M; Kodell Ralph L
Analysis of in vivo mutation data can inform cancer risk assessment.
Regulatory toxicology and pharmacology : RTP 2008;51(2):151-61.
2007: Bendre Sachin V; Shaddock Joseph G; Dobrovolsky Vasily N; Albertini Richard J; Heflich Robert H
Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice.
Environmental and molecular mutagenesis 2007;48(9):744-53.
2007: Dobrovolsky Vasily N; Heflich Robert H
On the use of the T-REx tetracycline-inducible gene expression system in vivo.
Biotechnology and bioengineering 2007;98(3):719-23.
2007: Dobrovolsky Vasily N; Shaddock Joseph G; Mittelstaedt Roberta A; Bishop Michelle E; Lewis Sherry M; Lee Fei W; Aidoo Anane; Leakey Julian E A; Dunnick June K; Heflich Robert H
Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC.
Environmental and molecular mutagenesis 2007;48(3-4):270-82.
2007: Von Tungeln Linda S; Williams Lee D; Doerge Daniel R; Shaddock Joseph G; McGarrity Lynda J; Morris Suzanne M; Mittelstaedt Roberta A; Heflich Robert H; Beland Frederick A
Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine.
Environmental and molecular mutagenesis 2007;48(3-4):258-69.
2007: Wang Jianyong; Heflich Robert H; Moore Martha M
A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay.
Mutation research 2007;626(1-2):185-90.
2006: Mei Nan; Arlt Volker M; Phillips David H; Heflich Robert H; Chen Tao
DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.
Mutation research 2006;602(1-2):83-91.
2006: Shaddock Joseph G; Dobrovolsky Vasily N; Mittelstaedt Roberta A; Heflich Robert H; Parsons Barbara L
Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice.
Mutation research 2006;595(1-2):69-79.
2006: Parsons Barbara L; Delongchamp Robert R; Beland Frederick A; Heflich Robert H
Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency.
Mutagenesis 2006;21(1):29-34.
2005: Chen Tao; Mittelstaedt Roberta A; Beland Frederick A; Heflich Robert H; Moore Martha M; Parsons Barbara L
4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice.
International journal of cancer. Journal international du cancer 2005;117(2):182-7.
2005: Bendre Sachin V; Shaddock Joseph G; Patton Ralph E; Dobrovolsky Vasily N; Albertini Richard J; Heflich Robert H
Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine.
Mutation research 2005;578(1-2):1-14.
2005: Dobrovolsky Vasily N; Bowyer John F; Pabarcus Michael K; Heflich Robert H; Williams Lee D; Doerge Daniel R; Arvidsson Björn; Bergquist Jonas; Casida John E
Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.
Biochimica et biophysica acta 2005;1724(1-2):163-72.
2005: Mei Nan; Heflich Robert H; Moore Martha M; Chen Tao
Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver.
Mutation research 2005;572(1-2):14-26.
2005: Parsons Barbara L; Beland Frederick A; Von Tungeln Linda S; Delongchamp Robert R; Fu Peter P; Heflich Robert H
Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.
Molecular carcinogenesis 2005;42(4):193-201.
2005: Mei N; Guo L; Fu P P; Heflich R H; Chen T
Mutagenicity of comfrey (Symphytum Officinale) in rat liver.
British journal of cancer 2005;92(5):873-5.
2005: Dobrovolsky Vasily N; McGarrity Lynda J; VonTungeln Linda S; Mittelstaedt Roberta A; Morris Suzanne M; Beland Frederick A; Heflich Robert H
Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice.
Mutation research 2005;570(2):227-35.
2005: Parsons Barbara L; McKinzie Page B; Heflich Robert H
Allele-specific competitive blocker-PCR detection of rare base substitution.
Methods in molecular biology (Clifton, N.J.) 2005;291():235-45.
2005: Dobrovolsky Vasily N; Shaddock Joseph G; Heflich Robert H
Analysis of in vivo mutation in the hprt and tk genes of mouse lymphocytes.
Methods in molecular biology (Clifton, N.J.) 2005;291():133-44.
2004: Mei Nan; Chou Ming W; Fu Peter P; Heflich Robert H; Chen Tao
Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats.
Cancer letters 2004;215(2):151-8.
2004: Wang Jianyong; Liu Xiaoli; Heflich Robert H; Chen Tao
Time course of cII gene mutant manifestation in the liver, spleen, and bone marrow of N-ethyl-N-nitrosourea-treated Big Blue transgenic mice.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(1):124-8.
2004: Mittelstaedt Roberta A; Mei Nan; Webb Peggy J; Shaddock Joseph G; Dobrovolsky Vasily N; McGarrity Lynda J; Morris Suzanne M; Chen Tao; Beland Frederick A; Greenlees Kevin J; Heflich Robert H
Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.
Mutation research 2004;561(1-2):127-38.
2004: Von Tungeln Linda S; Dobrovolsky Vasily N; Bishop Michelle E; Shaddock Joseph G; Heflich Robert H; Beland Frederick A
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine.
Mutagenesis 2004;19(4):307-11.
2004: Mei Nan; Heflich Robert H; Chou Ming W; Chen Tao
Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats.
Chemical research in toxicology 2004;17(6):814-8.
2004: Mittelstaedt Roberta A; Von Tungeln Linda S; Shaddock Joseph G; Dobrovolsky Vasily N; Beland Frederick A; Heflich Robert H
Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).
Mutation research 2004;547(1-2):63-9.
2004: Manjanatha M G; Shelton S D; Bishop M; Shaddock J G; Dobrovolsky V N; Heflich R H; Webb P J; Blankenship L R; Beland F A; Greenlees K J; Culp S J
Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green.
Mutation research 2004;547(1-2):5-18.
2004: Heflich Robert H
The journal celebrates an anniversary.
Environmental and molecular mutagenesis 2004;43(1):1-2.
2003: Thybaud Véronique; Dean Stephen; Nohmi Takehiko; de Boer Johan; Douglas George R; Glickman Barry W; Gorelick Nancy J; Heddle John A; Heflich Robert H; Lambert Iain; Martus Hans-Jörg; Mirsalis Jon C; Suzuki Takayoshi; Yajima Nobuhiro
In vivo transgenic mutation assays.
Mutation research 2003;540(2):141-51.
2003: Dobrovolsky Vasily N; McKinzie Page B; Shaddock Joseph G; Mittelstaedt Roberta A; Heflich Robert H; Parsons Barbara L
Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.
Mutagenesis 2003;18(4):365-70.
2003: Aidoo Anane; Mittelstaedt Roberta A; Bishop Michelle E; Lyn-Cook Lascelles E; Chen Yi-Ju; Duffy Peter; Heflich Robert H
Effect of caloric restriction on Hprt lymphocyte mutation in aging rats.
Mutation research 2003;527(1-2):57-66.
2003: Khaidakov Magomed; Heflich Robert H; Manjanatha Mugimane G; Myers Meagan B; Aidoo Anane
Accumulation of point mutations in mitochondrial DNA of aging mice.
Mutation research 2003;526(1-2):1-7.
2003: Dobrovolsky Vasily N; Bucci Thomas; Heflich Robert H; Desjardins John; Richardson Frank C
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
Molecular genetics and metabolism 2003;78(1):1-10.
2002: Culp S J; Beland F A; Heflich R H; Benson R W; Blankenship L R; Webb P J; Mellick P W; Trotter R W; Shelton S D; Greenlees K J; Manjanatha M G
Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.
Mutation research 2002;506-507():55-63.
2002: Von Tungeln Linda S; Hamilton L Patrice; Dobrovolsky Vasily N; Bishop Michelle E; Shaddock Joseph G; Heflich Robert H; Beland Frederick A
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine.
Carcinogenesis 2002;23(9):1427-32.
2002: Parsons Barbara L; Culp Sandra J; Manjanatha Mugimane G; Heflich Robert H
Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
Carcinogenesis 2002;23(6):943-8.
2002: Dobrovolsky Vasily N; McGarrity Lynda J; Morris Suzanne M; Heflich Robert H
Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter.
Mutation research 2002;518(1):55-64.
2002: Dobrovolsky Vasily N; Shaddock Joseph G; Heflich Robert H
Mutagenicity of gamma-radiation, mitomycin C, and etoposide in the Hprt and Tk genes of Tk(+/-) mice.
Environmental and molecular mutagenesis 2002;39(4):342-7.
2001: McKinzie P B; Delongchamp R R; Heflich R H; Parsons B L
Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment.
Mutation research 2001;489(1):47-78.
2001: Chen T; Mittelstaedt R A; Shelton S D; Dass S B; Manjanatha M G; Casciano D A; Heflich R H
Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.
Environmental and molecular mutagenesis 2001;37(3):203-14.
2001: Chen T; Mittelstaedt R A; Aidoo A; Hamilton L P; Beland F A; Casciano D A; Heflich R H
Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats.
Environmental and molecular mutagenesis 2001;37(3):195-202.
2000: Dobrovolsky V N; Shaddock J G; Heflich R H
7,12-dimethylbenz[a]anthracene-induced mutation in the Tk gene of Tk(+/-) mice: automated scoring of lymphocyte clones using a fluorescent viability indicator.
Environmental and molecular mutagenesis 2000;36(4):283-91.
1999: Mittelstaedt R A; Smith B A; Chen T; Beland F A; Heflich R H
Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene.
Mutation research 1999;431(1):167-73.
1999: Casciano D A; Aidoo A; Chen T; Mittelstaedt R A; Manjanatha M G; Heflich R H
Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens.
Mutation research 1999;431(2):389-95.
1999: Von Tungeln L S; Xia Q; Herreno-Saenz D; Bucci T J; Heflich R H; Fu P P
Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice.
Cancer letters 1999;146(1):1-7.
1999: Beland F A; Fullerton N F; Smith B A; Mittelstaedt R A; Heflich R H
Hprt lymphocyte mutant frequency in relation to DNA adduct formation in rats fed the hepatocarcinogen 2-acetylaminofluorene.
Cancer letters 1999;143(2):249-55.
1999: Chen J B; Dobrovolsky V N; Heflich R H
Development of a mouse cell line containing the PhiX174 am3 allele as a target for detecting mutation.
Mutation research 1999;444(2):347-53.
1999: Dass S B; Bucci T J; Heflich R H; Casciano D A
Evaluation of the transgenic p53+/- mouse for detecting genotoxic liver carcinogens in a short-term bioassay.
Cancer letters 1999;143(1):81-5.
1999: Von Tungeln L S; Xia Q; Bucci T; Heflich R H; Fu P P
Tumorigenicity and liver tumor ras-protooncogene mutations in CD-1 mice treated neonatally with 1- and 3-nitrobenzo[a]pyrene and their trans-7,8-dihydrodiol and aminobenzo[a]pyrene metabolites.
Cancer letters 1999;137(2):137-43.
1999: Delongchamp R R; Malling H V; Chen J B; Heflich R H
An estimator of the mutant frequency in assays using transgenic animals.
Mutation research 1999;440(1):101-8.
1999: Chen T; Aidoo A; Mittelstaedt R A; Casciano D A; Heflich R H
Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa.
Carcinogenesis 1999;20(2):269-77.
1999: Dobrovolsky V N; Casciano D A; Heflich R H
Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene.
Mutation research 1999;423(1-2):125-36.
1999: Dobrovolsky V N; Chen T; Heflich R H
Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes.
Environmental and molecular mutagenesis 1999;34(1):30-8.
1998: Parsons B L; Heflich R H
Detection of a mouse H-ras codon 61 mutation using a modified allele-specific competitive blocker PCR genotypic selection method.
Mutagenesis 1998;13(6):581-8.
1998: Chen T; Aidoo A; Manjanatha M G; Mittelstaedt R A; Shelton S D; Lyn-Cook L E; Casciano D A; Heflich R H
Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.
Mutation research 1998;403(1-2):199-214.
1998: Chen T; Mittelstaedt R A; Heflich R H
DNA sequence flanking the protein coding regions of the rat Hprt gene.
Mutation research 1998;382(3-4):79-80.
1998: Dass S B; Hammons G J; Bucci T J; Heflich R H; Casciano D A
Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine in the neonatal bioassay.
Cancer letters 1998;124(1):105-10.
1998: Xia Q; Yi P; Zhan D J; Von Tungeln L S; Hart R W; Heflich R H; Fu P P
Liver tumors induced in B6C3F1 mice by 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene contain K-ras protooncogene mutations.
Cancer letters 1998;123(1):21-5.
1998: Chen J B; Dass S B; Burkhart J G; Heflich R H
Sensitivity of the phiX174 am3 allele in relation to the endogenous Hprt gene for detecting mutation in transgenic mice.
Environmental and molecular mutagenesis 1998;32(3):229-35.
1998: Parsons B L; Heflich R H
Detection of basepair substitution mutation at a frequency of 1 x 10(-7) by combining two genotypic selection methods, MutEx enrichment and allele-specific competitive blocker PCR.
Environmental and molecular mutagenesis 1998;32(3):200-11.
1998: Dass S B; Heflich R H; Casciano D A
Mutational response at the splenic T-lymphocyte hprt locus in mice treated as neonates: contrasting effects of the carcinogens N-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Environmental and molecular mutagenesis 1998;31(3):243-7.
1998: Mittelstaedt R A; Manjanatha M G; Shelton S D; Lyn-Cook L E; Chen J B; Aidoo A; Casciano D A; Heflich R H
Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats.
Environmental and molecular mutagenesis 1998;31(2):149-56.
1998: Chen T; Aidoo A; Casciano D A; Heflich R H
Expansion of rat 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester.
Environmental and molecular mutagenesis 1998;31(1):97-102.
1998: Zhan D J; Chiu L H; Heflich R H; Fu P P
Molecular characterization of hprt mutations from Chinese hamster ovary cells treated with 1-, 3-, and 6-nitrosobenzo[a]pyrene.
Environmental and molecular mutagenesis 1998;31(1):60-9.
1997: Dass S B; Ali S F; Heflich R H; Casciano D A
Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice.
Mutation research 1997;381(1):105-10.
1997: Dass S B; Heflich R H; Casciano D A
The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size.
Carcinogenesis 1997;18(11):2233-7.
1997: Parsons B L; Heflich R H
Genotypic selection methods for the direct analysis of point mutations.
Mutation research 1997;387(2):97-121.
1997: Smith B A; Manjanatha M G; Pogribny I P; Mittelstaedt R A; Chen T; Fullerton N F; Beland F A; Heflich R H
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
Mutation research 1997;379(1):61-8.
1997: Zhan D J; Chiu L H; Von Tungeln L S; Herreno-Saenz D; Cheng E; Evans F E; Heflich R H; Fu P P
Characterization of DNA adducts in Chinese hamster ovary cells treated with mutagenic doses of 1- and 3-nitrosobenzo[a]pyrene and the trans-7,8-diol-anti-9,10-epoxides of 1- and 3-nitrobenzo[a]pyrene.
Mutation research 1997;379(1):43-52.
1997: Valentine C R; Heflich R H
The association of nonsense mutation with exon-skipping in hprt mRNA of Chinese hamster ovary cells results from an artifact of RT-PCR.
RNA (New York, N.Y.) 1997;3(6):660-76.
1997: Fu P P; Qui F Y; Jung H; Von Tungeln L S; Zhan D J; Lee M J; Wu Y S; Heflich R H
Metabolism of isomeric nitrobenzo[a]pyrenes leading to DNA adducts and mutagenesis.
Mutation research 1997;376(1-2):43-51.
1997: Parsons B L; Heflich R H
Evaluation of MutS as a tool for direct measurement of point mutations in genomic DNA.
Mutation research 1997;374(2):277-85.
1996: Manjanatha M G; Lyn-Cook L E; Culp S J; Beland F A; Heflich R H; Aidoo A
Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz[a]anthracene.
Mutation research 1996;357(1-2):89-96.
1996: Delclos K B; Blaydes B; Heflich R H; Smith B A
Assessment of DNA adducts and the frequency of 6-thioguanine resistant T-lymphocytes in F344 rats fed 2,4-toluenediamine or implanted with a toluenediisocyanate-containing polyester polyurethane foam.
Mutation research 1996;367(4):210-8.
1996: Manjanatha M G; Li E E; Fu P P; Heflich R H
H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice.
Journal of toxicology and environmental health 1996;47(2):195-208.
1996: Dobrovolsky V N; Casciano D A; Heflich R H
Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies.
Environmental and molecular mutagenesis 1996;28(4):483-9.
1996: Heflich R H; Mittelstaedt R A; Manjanatha M G; Lyn-Cook L E; Aidoo A
DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene.
Environmental and molecular mutagenesis 1996;28(1):5-12.
1996: Zhan D J; Heflich R H; Fu P P
Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8- diol-anti-9,10-epoxide.
Environmental and molecular mutagenesis 1996;27(1):19-29.
1995: Smith B A; Fullerton N F; Heflich R H; Beland F A
DNA adduct formation and T-lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene.
Cancer research 1995;55(11):2316-24.
1995: Mittelstaedt R A; Smith B A; Heflich R H
Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes.
Environmental and molecular mutagenesis 1995;26(4):261-9.
1995: Valentine C R; Heflich R H
Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells.
Environmental and molecular mutagenesis 1995;25(2):85-96.
1994: Mittelstaedt R A; Heflich R H
Analysis of in vivo mutation in exon 8 of the rat hprt gene.
Mutation research 1994;311(1):139-48.
1994: Beland F A; Fullerton N F; Smith B A; Heflich R H
Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1,6-dinitropyrene.
Environmental health perspectives 1994;102 Suppl 6():185-9.
1994: Heflich R H; Neft R E
Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites.
Mutation research 1994;318(2):73-114.
1994: Li E E; Heflich R H; Bucci T J; Manjanatha M G; Blaydes B S; Delclos K B
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Carcinogenesis 1994;15(7):1377-85.
1994: Manjanatha M G; Lindsey L A; Mittelstaedt R A; Heflich R H
Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations.
Mutation research 1994;308(1):65-75.
1993: Li E E; Heflich R H; Delclos K B
Trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene is metabolized to form a major adduct with deoxyguanosine and produces mutations in the hprt gene of Chinese hamster ovary cells at G:C basepairs.
Carcinogenesis 1993;14(10):2109-14.
1993: Manjanatha M G; Newton R K; Mittelstaedt R A; Villani G R; Declos K B; Heflich R H
Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells.
Carcinogenesis 1993;14(9):1863-70.
1993: Smith B A; Fullerton N F; Aidoo A; Heflich R H; Beland F A
DNA adduct formation in relation to lymphocyte mutations and lung tumor induction in F344 rats treated with the environmental pollutant 1,6-dinitropyrene.
Environmental health perspectives 1993;99():277-80.
1993: Aidoo A; Lyn-Cook L E; Heflich R H; George E O; Casciano D A
The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea.
Mutation research 1993;298(3):169-78.
1993: Delclos K B; Manjanatha M G; Li E E; Newton R K; Mittelstaedt R A; Heflich R H
32P-postlabelling in studies of arylamine and nitroaromatic hydrocarbon activation and mutagenesis.
IARC scientific publications 1993;(124):79-86.
1992: Beland F A; Smith B A; Thornton-Manning J R; Heflich R H
Metabolic activation of 1-nitropyrene to a mammalian cell mutagen and a carcinogen.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(9-10):1121-33.
1992: Delclos K B; Heflich R H
Mutation induction and DNA adduct formation in Chinese hamster ovary cells treated with 6-nitrochrysene, 6-aminochrysene and their metabolites.
Mutation research 1992;279(3):153-64.
1992: Newton R K; Mittelstaedt R A; Manjanatha M G; Heflich R H
DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells.
Carcinogenesis 1992;13(5):819-25.
1992: Pothuluri J V; Heflich R H; Fu P P; Cerniglia C E
Fungal metabolism and detoxification of fluoranthene.
Applied and environmental microbiology 1992;58(3):937-41.
1992: Newton R K; Mittelstaedt R A; Heflich R H
Analysis of solvent control and 1-nitrosopyrene-induced Chinese hamster ovary cell mutants by Southern and northern blots and the polymerase chain reaction.
Environmental and molecular mutagenesis 1992;19(2):147-55.
1991: Thornton-Manning J R; Smith B A; Beland F A; Heflich R H
S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions.
Carcinogenesis 1991;12(12):2317-23.
1991: Yu S Y; Heflich R H; Von Tungeln L S; el-Bayoumy K; Kadlubar F F; Fu P P
Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts.
Mutation research 1991;250(1-2):145-52.
1991: Thornton-Manning J R; Smith B A; Beland F A; Heflich R H
Mutagenesis and DNA adduct formation by 1-nitropyrene in Chinese hamster ovary cells without exogenous metabolic activation.
Toxicology and applied pharmacology 1991;109(3):538-46.
1991: Jung H; Shaikh A U; Heflich R H; Fu P P
Nitro group orientation, reduction potential, and direct-acting mutagenicity of nitro-polycyclic aromatic hydrocarbons.
Environmental and molecular mutagenesis 1991;17(3):169-80.
1991: Aidoo A; Lyn-Cook L E; Mittelstaedt R A; Heflich R H; Casciano D A
Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats following in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide.
Environmental and molecular mutagenesis 1991;17(3):141-51.
1991: Gao N; Aidoo A; Heflich R H
Analysis of rat lymphocyte activation of benzo[a]pyrene, 2-acetylaminofluorene, and several of their metabolites to mutagenic and DNA-damaging species in vitro.
Teratogenesis, carcinogenesis, and mutagenesis 1991;11(2):65-76.
1990: Fu P P; Jung H; Von Tungeln L S; Heflich R H
Mutagenicity of mononitrodihydrobenzo[a]pyrenes.
Mutation research 1990;245(4):277-85.
1990: Heflich R H; Thornton-Manning J R; Kinouchi T; Beland F A
Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells.
Mutagenesis 1990;5(2):151-7.
1990: Aidoo A; Gao N; Neft R E; Schol H M; Hass B S; Minor T Y; Heflich R H
Evaluation of the genotoxicity of gentian violet in bacterial and mammalian cell systems.
Teratogenesis, carcinogenesis, and mutagenesis 1990;10(6):449-62.
1989: Heflich R H; Hass B S; Chen J J; Thornton-Manning J R; Fu P P
Reply to 'Comment on the Non-Additivity of the Mutagenic Response of Mixtures of Nitrobenzo[a]Pyrenes'.
Mutation research 1989;227(1):69-71.
1989: Gao N; Ni Y C; Thornton-Manning J R; Fu P P; Heflich R H
Mutagenicity of nitrofurantoin and furazolidone in Chinese hamster ovary cell strains.
Mutation research 1989;225(4):181-7.
1989: Heflich R H; Unruh L E; Thornton-Manning J R; von Tungeln L S; Fu P P
Mutagenicity of 1-, 3- and 6-nitrosobenzo[a]pyrene in Salmonella typhimurium and Chinese hamster ovary cells.
Mutation research 1989;225(4):157-63.
1989: Fu P P; Ni Y C; Zhang Y M; Heflich R H; Wang Y K; Lai J S
Effect of the orientation of nitro substituent on the bacterial mutagenicity of dinitrobenzo[e]pyrenes.
Mutation research 1989;225(3):121-5.
1989: Shaddock J G; Heflich R H; McMillan D C; Hinson J A; Casciano D A
Pretreatment with mixed-function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay.
Environmental and molecular mutagenesis 1989;13(4):281-8.
1989: Thornton-Manning J R; Campbell W L; Hass B S; Chen J J; Fu P P; Cerniglia C E; Heflich R H
Role of nitroreduction in the synergistic mutational response induced by mixtures of 1- and 3-nitrobenzo[a]pyrene in Salmonella typhimurium.
Environmental and molecular mutagenesis 1989;13(3):203-10.
1988: Fu P P; Cerniglia C E; Richardson K E; Heflich R H
Nitroreduction of 6-nitrobenzo[a]pyrene: a potential activation pathway in humans.
Mutation research 1988;209(3-4):123-9.
1988: Fu P P; Heflich R H; Unruh L E; Shaikh A U; Wu Y S; Lai C C; Lai J S
Relationships among direct-acting mutagenicity, nitro group orientation and polarographic reduction potential of 6-nitrobenzo[a]pyrene, 7-nitrobenz[a]anthracene and their derivatives.
Mutation research 1988;209(3-4):115-22.
1988: McMillan D C; Shaddock J G; Heflich R H; Casciano D A; Hinson J A
Evaluation of propanil and its N-oxidized derivatives for genotoxicity in the Salmonella typhimurium reversion, Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase, and rat hepatocyte/DNA repair assays.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1988;11(3):429-39.
1988: Fu P P; Heflich R H; Von Tungeln L S; Miranda H Z; Evans F E
Microsomal metabolism of 1-nitrobenzo[e]pyrene to a highly mutagenic K-region dihydrodiol.
Carcinogenesis 1988;9(6):951-8.
1988: Thornton-Manning J R; Chou M W; Fu P P; Heflich R H
Microsomal activation of 1- and 3-nitrobenzo[a]pyrene to mutagens in Chinese hamster ovary cells.
Mutagenesis 1988;3(3):233-7.
1988: Hansen E B; Heflich R H; Korfmacher W A; Miller D W; Cerniglia C E
Microbial transformation of the antihistaminic drug triprolidine hydrochloride.
Journal of pharmaceutical sciences 1988;77(3):259-64.
1988: Heflich R H; Djuric Z; Zhuo Z; Fullerton N F; Casciano D A; Beland F A
Metabolism of 2-acetylaminofluorene in the Chinese hamster ovary cell mutation assay.
Environmental and molecular mutagenesis 1988;11(2):167-81.
1987: Ni Y C; Heflich R H; Kadlubar F F; Fu P P
Mutagenicity of nitrofurans in Salmonella typhimurium TA98, TA98NR and TA98/1,8-DNP6.
Mutation research 1987;192(1):15-22.
1987: Hass B S; Chen J J; Chou M W; Fu P P; Heflich R H
Binary mixtures containing isomers of nitrobenzo[a]pyrene induce greater-than-additive mutational responses in Salmonella typhimurium. I. Analysis by the total concentration-proportional mixture model.
Mutation research 1987;190(4):247-52.
1987: Hansen E B; Cerniglia C E; Korfmacher W A; Miller D W; Heflich R H
Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(1):97-106.
1986: Fifer E K; Howard P C; Heflich R H; Beland F A
Synthesis and mutagenicity of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide, microsomal metabolites of 1-nitropyrene.
Mutagenesis 1986;1(6):433-8.
1986: Hass B S; Heflich R H; Chou M W; White G L; Fu P P; Casciano D A
Hepatocyte-mediated mutagenicity of mononitrobenzo[a]pyrenes in Salmonella typhimurium strains.
Mutation research 1986;171(2-3):123-9.
1986: Heflich R H; Morris S M; Beranek D T; McGarrity L J; Chen J J; Beland F A
Relationships between the DNA adducts and the mutations and sister-chromatid exchanges produced in Chinese hamster ovary cells by N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene.
Mutagenesis 1986;1(3):201-6.
1986: Hass B S; Heflich R H; Schol H M; Chou M W; Fu P P; Casciano D A
Mutagenicity of the mononitrobenzo[a]pyrenes in Chinese hamster ovary cells mediated by rat hepatocytes or liver S9.
Carcinogenesis 1986;7(4):681-4.
1986: Fifer E K; Heflich R H; Djuric Z; Howard P C; Beland F A
Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene.
Carcinogenesis 1986;7(1):65-70.
1986: Heflich R H; Djuric Z; Fifer E K; Cerniglia C E; Beland F A
Metabolism of dinitropyrenes to DNA-binding derivatives in vitro and in vivo.
Developments in toxicology and environmental science 1986;13():185-97.
1986: Heflich R H; Fifer E K; Djuric Z; Beland F A
Mutation induction and DNA adduct formation by 1,8-dinitropyrene in Chinese hamster ovary cells.
Progress in clinical and biological research 1986;209A():265-73.
1985: Heflich R H; Fifer E K; Djuric Z; Beland F A
DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.
Environmental health perspectives 1985;62():135-43.

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