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Fausto Hegardt

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Publications

  • TOP 3
  • Beatriz Puisac; Mónica Ramos; María Arnedo; Sebastián Menao; María Concepción Gil-Rodríguez; María Esperanza Teresa-Rodrigo; Angeles Pié; Juan Carlos de Karam; Jan-Jaap Wesselink; Ignacio Giménez; et al.
    Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.
  • Su Gao; Wendy Keung; Dolors Serra; Wei Wang; Patricia Carrasco; Nuria Casals; Fausto G Hegardt; Timothy H Moran; Gary D Lopaschuk
    Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.
  • Su Gao; Guangjing Zhu; Xuefei Gao; Donghai Wu; Patricia Carrasco; Núria Casals; Fausto G Hegardt; Timothy H Moran; Gary D Lopaschuk
    Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.
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All Publications

  • 2012: Beatriz Puisac; Mónica Ramos; María Arnedo; Sebastián Menao; María Concepción Gil-Rodríguez; María Esperanza Teresa-Rodrigo; Angeles Pié; Juan Carlos de Karam; Jan-Jaap Wesselink; Ignacio Giménez; et al.
    Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.
    Molecular biology reports 2012;39(4):4777-85.
  • 2011: Su Gao; Wendy Keung; Dolors Serra; Wei Wang; Patricia Carrasco; Nuria Casals; Fausto G Hegardt; Timothy H Moran; Gary D Lopaschuk
    Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.
    American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(1):R209-17.
  • 2011: Su Gao; Guangjing Zhu; Xuefei Gao; Donghai Wu; Patricia Carrasco; Núria Casals; Fausto G Hegardt; Timothy H Moran; Gary D Lopaschuk
    Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.
    Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9691-6.
  • 2011: Josep M Orellana-Gavaldà; Laura Herrero; Maria Ida Malandrino; Astrid Pañeda; Maria Sol Rodríguez-Peña; Harald Petry; Guillermina Asins; Sander Van Deventer; Fausto G Hegardt; Dolors Serra
    Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.
    Hepatology (Baltimore, Md.) 2011;53(3):821-32.
  • 2010: Beatriz Puisac; María Arnedo; Cesar H Casale; María Pilar Ribate; Tomás Castiella; Feliciano J Ramos; Antonia Ribes; Celia Pérez-Cerdá; Nuria Casals; Fausto G Hegardt; et al.
    Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria.
    Journal of inherited metabolic disease 2010;33(4):405-10.
  • 2010: Juan Pié; María Concepción Gil-Rodríguez; Milagros Ciero; Eduardo López-Viñas; María Pilar Ribate; María Arnedo; Matthew A Deardorff; Beatriz Puisac; Jesús Legarreta; Juan Carlos de Karam; et al.
    Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome.
    American journal of medical genetics. Part A 2010;152A(4):924-9.
  • 2009: David Sebastián; Maria Guitart; Celia García-Martínez; Caroline Mauvezin; Josep M Orellana-Gavaldà; Dolors Serra; Anna M Gómez-Foix; Fausto G Hegardt; Guillermina Asins
    Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.
    Journal of lipid research 2009;50(9):1789-99.
  • 2009: Robert C Noland; Timothy R Koves; Sarah E Seiler; Helen Lum; Robert M Lust; Olga Ilkayeva; Robert D Stevens; Fausto G Hegardt; Deborah M Muoio
    Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
    The Journal of biological chemistry 2009;284(34):22840-52.
  • 2009: Paula Mera; Assia Bentebibel; Eduardo López-Viñas; Antonio G Cordente; Chandrashekaran Gurunathan; David Sebastián; Irene Vázquez; Laura Herrero; Xavier Ariza; Paulino Gómez-Puertas; et al.
    C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
    Biochemical pharmacology 2009;77(6):1084-95.
  • 2009: Sebastián Menao; Eduardo López-Viñas; Cecilia Mir; Beatriz Puisac; Esther Gratacós; María Arnedo; Patricia Carrasco; Susana Moreno; Mónica Ramos; María Concepción Gil; et al.
    Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria.
    Human mutation 2009;30(3):E520-9.
  • 2008: Adriana Y Sierra; Esther Gratacós; Patricia Carrasco; Josep Clotet; Jesús Ureña; Dolors Serra; Guillermina Asins; Fausto G Hegardt; Núria Casals
    CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.
    The Journal of biological chemistry 2008;283(11):6878-85.
  • 2007: Juan Pié; Eduardo López-Viñas; Beatriz Puisac; Sebastián Menao; Angeles Pié; Cesar Casale; Feliciano J Ramos; Fausto G Hegardt; Paulino Gómez-Puertas; Núria Casals
    Molecular genetics of HMG-CoA lyase deficiency.
    Molecular genetics and metabolism 2007;92(3):198-209.
  • 2007: Olga Jáuregui; Adriana Y Sierra; Patricia Carrasco; Esther Gratacós; Fausto G Hegardt; Núria Casals
    A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.
    Analytica chimica acta 2007;599(1):1-6.
  • 2007: Eduardo López-Viñas; Assia Bentebibel; Chandrashekaran Gurunathan; Montserrat Morillas; Dolores de Arriaga; Dolors Serra; Guillermina Asins; Fausto G Hegardt; Paulino Gómez-Puertas
    Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.
    The Journal of biological chemistry 2007;282(25):18212-24.
  • 2007: Patricia Carrasco; Sebastian Menao; Eduardo López-Viñas; Gabriel Santpere; Josep Clotet; Adriana Y Sierra; Esther Gratacós; Beatriz Puisac; Paulino Gómez-Puertas; Fausto G Hegardt; et al.
    C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.
    Molecular genetics and metabolism 2007;91(2):120-7.
  • 2007: Wen Guo; Tamar Pirtskhalava; Tamara Tchkonia; Weisheng Xie; Thomas Thomou; Jianrong Han; Tong Wang; Siu Wong; Andrew Cartwright; Fausto G Hegardt; et al.
    Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
    American journal of physiology. Endocrinology and metabolism 2007;292(4):E1041-51.
  • 2007: David Sebastián; Laura Herrero; Dolors Serra; Guillermina Asins; Fausto G Hegardt
    CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.
    American journal of physiology. Endocrinology and metabolism 2007;292(3):E677-86.
  • 2007: Antonio G Cordente; Jan H Swiegers; Fausto G Hegardt; Isak S Pretorius
    Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae.
    FEMS microbiology letters 2007;267(2):159-66.
  • 2006: Antonio G Cordente; Eduardo López-Viñas; María Irene Vázquez; Paulino Gómez-Puertas; Guillermina Asins; Dolors Serra; Fausto G Hegardt
    Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.
    Biochemistry 2006;45(19):6133-41.
  • 2006: Assia Bentebibel; David Sebastián; Laura Herrero; Eduardo López-Viñas; Dolors Serra; Guillermina Asins; Paulino Gómez-Puertas; Fausto G Hegardt
    Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.
    Biochemistry 2006;45(14):4339-50.
  • 2006: R Aledo; C Mir; R N Dalton; C Turner; J Pié; F G Hegardt; N Casals; M P Champion
    Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
    Journal of inherited metabolic disease 2006;29(1):207-11.
  • 2006: C Mir; E Lopez-Viñas; R Aledo; B Puisac; C Rizzo; C Dionisi-Vici; F Deodato; J Pié; P Gomez-Puertas; F G Hegardt; et al.
    A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase.
    Journal of inherited metabolic disease 2006;29(1):64-70.
  • 2005: Beatriz Puisac; Eduardo López-Viñas; Susana Moreno; Cecilia Mir; Celia Pérez-Cerdá; Sebastián Menao; Dolores Lluch; Angeles Pié; Paulino Gómez-Puertas; Nuria Casals; et al.
    Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL.
    Biophysical chemistry 2005;115(2-3):241-5.
  • 2005: Laura Herrero; Blanca Rubí; David Sebastián; Dolors Serra; Guillermina Asins; Pierre Maechler; Marc Prentki; Fausto G Hegardt
    Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.
    Diabetes 2005;54(2):462-71.
  • 2004: Antonio G Cordente; Eduardo López-Viñas; María Irene Vázquez; Jan H Swiegers; Isak S Pretorius; Paulino Gómez-Puertas; Fausto G Hegardt; Guillermina Asins; Dolors Serra
    Redesign of carnitine acetyltransferase specificity by protein engineering.
    The Journal of biological chemistry 2004;279(32):33899-908.
  • 2004: Montserrat Morillas; Eduardo López-Viñas; Alfonso Valencia; Dolors Serra; Paulino Gómez-Puertas; Fausto G Hegardt; Guillermina Asins
    Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.
    The Biochemical journal 2004;379(Pt 3):777-84.
  • 2003: J Pie; N Casals; B Puisac; F G Hegardt
    Molecular basis of 3-hydroxy-3-methylglutaric aciduria.
    Journal of physiology and biochemistry 2003;59(4):311-21.
  • 2003: Núria Casals; Paulino Gómez-Puertas; Juan Pié; Cecilia Mir; Ramón Roca; Beatriz Puisac; Rosa Aledo; Josep Clotet; Sebastián Menao; Dolors Serra; et al.
    Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.
    The Journal of biological chemistry 2003;278(31):29016-23.
  • 2003: Montserrat Morillas; Paulino Gómez-Puertas; Assia Bentebibel; Eva Sellés; Nuria Casals; Alfonso Valencia; Fausto G Hegardt; Guillermina Asins; Dolors Serra
    Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
    The Journal of biological chemistry 2003;278(11):9058-63.
  • 2002: Corinne Lang; Simona Berardi; Markus Schäfer; Dolors Serra; Fausto G Hegardt; Lukas Krähenbühl; Stephan Krähenbühl
    Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction.
    Journal of hepatology 2002;37(5):564-71.
  • 2002: Johannes Zschocke; Johannes M Penzien; Rainer Bielen; Núria Casals; Rosa Aledo; Juan Pié; Georg F Hoffmann; Fausto G Hegardt; Ertan Mayatepek
    The diagnosis of mitochondrial HMG-CoA synthase deficiency.
    The Journal of pediatrics 2002;140(6):778-80.
  • 2002: Blanca Rubí; Peter A Antinozzi; Laura Herrero; Hisamitsu Ishihara; Guillermina Asins; Dolors Serra; Claes B Wollheim; Pierre Maechler; Fausto G Hegardt
    Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.
    The Biochemical journal 2002;364(Pt 1):219-26.
  • 2002: Montserrat Morillas; Paulino Gómez-Puertas; Blanca Rubí; Josep Clotet; Joaquín Ariño; Alfonso Valencia; Fausto G Hegardt; Dolors Serra; Guillermina Asins
    Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.
    The Journal of biological chemistry 2002;277(13):11473-80.
  • 2001: M Morillas; P Gómez-Puertas; R Roca; D Serra; G Asins; A Valencia; F G Hegardt
    Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.
    The Journal of biological chemistry 2001;276(48):45001-8.
  • 2001: B Rubi; H Ishihara; F G Hegardt; C B Wollheim; P Maechler
    GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.
    The Journal of biological chemistry 2001;276(39):36391-6.
  • 2001: C Caudevilla; C Codony; D Serra; G Plasencia; R Román; A Graessmann; G Asins; M Bach-Elias; F G Hegardt
    Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.
    Nucleic acids research 2001;29(14):3108-15.
  • 2001: R Aledo; J Zschocke; J Pié; C Mir; S Fiesel; E Mayatepek; G F Hoffmann; N Casals; F G Hegardt
    Genetic basis of mitochondrial HMG-CoA synthase deficiency.
    Human genetics 2001;109(1):19-23.
  • 2001: C Codony; S Guil; C Caudevilla; D Serra; G Asins; A Graessmann; F G Hegardt; M Bach-Elias
    Modulation in vitro of H-ras oncogene expression by trans-splicing.
    Oncogene 2001;20(28):3683-94.
  • 2001: F G Hegardt; M Bach; G Asins; C Caudevilla; M Morillas; C Codony; D Serra
    Post-transcriptional regulation of rat carnitine octanoyltransferase.
    Biochemical Society transactions 2001;29(Pt 2):316-20.
  • 2001: N Casals; C Buesa; P F Marrero; X Belles; F G Hegardt
    3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene.
    Insect biochemistry and molecular biology 2001;31(4-5):425-33.
  • 2001: C Nicot; F G Hegardt; G Woldegiorgis; D Haro; P F Marrero
    Pig liver carnitine palmitoyltransferase I, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes.
    Biochemistry 2001;40(7):2260-6.
  • 2001: M J Barrero; C S Alho; J A Ortiz; F G Hegardt; D Haro; P F Marrero
    Low activity of mitochondrial HMG-CoA synthase in liver of starved piglets is due to low levels of protein despite high mRNA levels.
    Archives of biochemistry and biophysics 2001;385(2):364-71.
  • 2001: A Miliar; D Serra; R Casaroli; S Vilaró; G Asins; F G Hegardt
    Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats.
    Archives of biochemistry and biophysics 2001;385(2):283-9.
  • 2001: J M Lopez; F G Hegardt; D Haro
    Differential expression of cytosolic and mitochondrial 3-hydroxy-3-methylglutaryl CoA synthases during adipocyte differentiation.
    Molecular and cellular biochemistry 2001;217(1-2):57-66.
  • 2001: C Lang; M Schäfer; D Serra; F Hegardt; L Krähenbühl; S Krähenbühl
    Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism.
    Journal of lipid research 2001;42(1):22-30.
  • 2000: M Morillas; J Clotet; B Rubí; D Serra; J Ariño; F G Hegardt; G Asins
    Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.
    The Biochemical journal 2000;351 Pt 2():495-502.
  • 2000: C Mascaró; A Nadal; F G Hegardt; P F Marrero; D Haro
    Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis.
    The Biochemical journal 2000;350 Pt 3():785-90.
  • 2000: C Mascaró; J A Ortiz; M M Ramos; D Haro; F G Hegardt
    Sterol regulatory element binding protein-mediated effect of fluvastatin on cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase transcription.
    Archives of biochemistry and biophysics 2000;374(2):286-92.
  • 2000: M Morillas; J Clotet; B Rubí; D Serra; G Asins; J Ariño; F G Hegardt
    Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver.
    FEBS letters 2000;466(1):183-6.
  • 2000: A Eggers; C Caudevilla; G Asins; F G Hegardt; D Serra
    Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells.
    The Biochemical journal 2000;345 Pt 2():201-6.
  • 1999: L Madsen; A Garras; G Asins; D Serra; F G Hegardt; R K Berge
    Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation.
    Biochemical pharmacology 1999;57(9):1011-9.
  • 1999: F G Hegardt
    Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis.
    The Biochemical journal 1999;338 ( Pt 3)():569-82.
  • 1999: J A Ortiz; J Mallolas; C Nicot; J Bofarull; J C Rodríguez; F G Hegardt; D Haro; P F Marrero
    Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element.
    The Biochemical journal 1999;337 ( Pt 2)():329-35.
  • 1999: C Caudevilla; D Serra; A Miliar; C Codony; G Asins; M Bach; F G Hegardt
    Processing of carnitine octanoyltransferase pre-mRNAs by cis and trans-splicing.
    Advances in experimental medicine and biology 1999;466():95-102.
  • 1999: C Mascaró; E Acosta; J A Ortiz; J C Rodríguez; P F Marrero; F G Hegardt; D Haro
    Characterization of a response element for peroxisomal proliferator activated receptor (PPRE) in human muscle-type carnitine palmitoyltransferase I.
    Advances in experimental medicine and biology 1999;466():79-85.
  • 1999: R K Berge; A Garras; G Asins; D Serra; F G Hegardt; L Madsen
    Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase and carnitine palmitoyltransferase II are potential control sites of hepatic ketogenesis under conditions of peroxisome proliferation.
    Lipids 1999;34 Suppl():S163.
  • 1998: N Zapater; J Pié; J Lloberas; M O Rolland; B Leroux; M Vidailhet; P Divry; F G Hegardt; N Casals
    Two missense point mutations in different alleles in the 3-hydroxy-3-methylglutaryl coenzyme A lyase gene produce 3-hydroxy-3-methylglutaric aciduria in a French patient.
    Archives of biochemistry and biophysics 1998;358(2):197-203.
  • 1998: C Caudevilla; D Serra; A Miliar; C Codony; G Asins; M Bach; F G Hegardt
    Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver.
    Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12185-90.
  • 1998: F G Hegardt
    Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis.
    Biochimie 1998;80(10):803-6.
  • 1998: C Mascaró; E Acosta; J A Ortiz; P F Marrero; F G Hegardt; D Haro
    Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor.
    The Journal of biological chemistry 1998;273(15):8560-3.
  • 1998: J C Rodríguez; J A Ortiz; F G Hegardt; D Haro
    The hepatocyte nuclear factor 4 (HNF-4) represses the mitochondrial HMG-CoA synthase gene.
    Biochemical and biophysical research communications 1998;242(3):692-6.
  • 1998: G Arias; G Asins; F G Hegardt; D Serra
    The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
    Molecular and cellular biochemistry 1998;178(1-2):325-33.
  • 1998: C H Casale; N Casals; J Pié; N Zapater; C Pérez-Cerdá; B Merinero; M Martínez-Pardo; J J García-Peñas; J M García-Gonzalez; R Lama; et al.
    A nonsense mutation in the exon 2 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing three mature mRNAs is the main cause of 3-hydroxy-3-methylglutaric aciduria in European Mediterranean patients.
    Archives of biochemistry and biophysics 1998;349(1):129-37.
  • 1997: N Casals; J Pié; C H Casale; N Zapater; A Ribes; M Castro-Gago; S Rodriguez-Segade; R J Wanders; F G Hegardt
    A two-base deletion in exon 6 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3-hydroxy-3-methylglutaric aciduria.
    Journal of lipid research 1997;38(11):2303-13.
  • 1997: J C Rodríguez; J A Ortiz; F G Hegardt; D Haro
    Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene.
    The Biochemical journal 1997;326 ( Pt 2)():587-92.
  • 1997: J Cabañó; C Buesa; F G Hegardt; P F Marrero
    Catalytic properties of recombinant 3-hydroxy-3-methylglutaryl coenzyme A synthase-1 from Blattella germanica.
    Insect biochemistry and molecular biology 1997;27(6):499-505.
  • 1997: S H Adams; C S Alho; G Asins; F G Hegardt; P F Marrero
    Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet.
    The Biochemical journal 1997;324 ( Pt 1)():65-73.
  • 1997: J Pié; N Casals; C H Casale; C Buesa; C Mascaró; A Barceló; M O Rolland; T Zabot; D Haro; F Eyskens; et al.
    A nonsense mutation in the 3-hydroxy-3-methylglutaryl-CoA lyase gene produces exon skipping in two patients of different origin with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
    The Biochemical journal 1997;323 ( Pt 2)():329-35.
  • 1997: G Arias; G Asins; F G Hegardt; D Serra
    The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
    Archives of biochemistry and biophysics 1997;340(2):287-98.
  • 1996: C Buesa; J Pié; A Barceló; N Casals; C Mascaró; C H Casale; D Haro; M Duran; J A Smeitink; F G Hegardt
    Aberrantly spliced mRNAs of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene with a donor splice-site point mutation produce hereditary HL deficiency.
    Journal of lipid research 1996;37(11):2420-32.
  • 1996: N Casals; C Buesa; M D Piulachs; J Cabañó; P F Marrero; X Bellés; F G Hegardt
    Coordinated expression and activity of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase in the fat body of Blattella germanica (L.) during vitellogenesis.
    Insect biochemistry and molecular biology 1996;26(8-9):837-43.
  • 1996: G Asins; D Serra; A Miliar; C Caudevilla; R Matas; G Arias; F G Hegardt
    Developmental changes in the phospho(enol)pyruvate carboxykinase gene expression in small intestine and liver of suckling rats.
    Archives of biochemistry and biophysics 1996;329(1):82-6.
  • 1996: D Serra; D Bellido; G Asins; G Arias; S Vilaró; F G Hegardt
    The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control.
    European journal of biochemistry / FEBS 1996;237(1):16-24.
  • 1996: D Serra; C Fillat; R Matas; F Bosch; F G Hegardt
    Tissue-specific expression and dietary regulation of chimeric mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase/human growth hormone gene in transgenic mice.
    The Journal of biological chemistry 1996;271(13):7529-34.
  • 1995: J Martinez-Gonzalez; F G Hegardt
    Characterization of a cDNA encoding a cytosolic peptidylprolyl cis-trans-isomerase from Blattella germanica.
    European journal of biochemistry / FEBS 1995;234(1):284-92.
  • 1995: F G Hegardt; D Serra; G Asins
    Influence of etomoxir on the expression of several genes in liver, testis and heart.
    General pharmacology 1995;26(5):897-904.
  • 1995: G Arias; R Matas; G Asins; F G Hegardt; D Serra
    The effect of fasting and insulin treatment on carnitine palmitoyl transferase I and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase mRNA levels in liver from suckling rats.
    Biochemical Society transactions 1995;23(3):493S.
  • 1995: F G Hegardt
    Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in liver and intestine from the rat.
    Biochemical Society transactions 1995;23(3):486-90.
  • 1995: C Mascaró; C Buesa; J A Ortiz; D Haro; F G Hegardt
    Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
    Archives of biochemistry and biophysics 1995;317(2):385-90.
  • 1995: G Asins; D Serra; G Arias; F G Hegardt
    Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats.
    The Biochemical journal 1995;306 ( Pt 2)():379-84.
  • 1995: T Royo; M J Pedragosa; J Ayté; G Gil-Gómez; S Vilaró; F G Hegardt
    Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver.
    Journal of cellular physiology 1995;162(1):103-9.
  • 1994: J A Ortiz; G Gil-Gómez; R P Casaroli-Marano; S Vilaró; F G Hegardt; D Haro
    Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate.
    The Journal of biological chemistry 1994;269(46):28523-6.
  • 1994: J C Rodríguez; G Gil-Gómez; F G Hegardt; D Haro
    Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
    The Journal of biological chemistry 1994;269(29):18767-72.
  • 1994: J Martínez-González; F G Hegardt
    Cytochrome c oxidase subunit I from the cockroach Blattella germanica: cloning, developmental pattern and tissue expression.
    Insect biochemistry and molecular biology 1994;24(6):619-26.
  • 1994: C Buesa; J Martínez-Gonzalez; N Casals; D Haro; M D Piulachs; X Bellés; F G Hegardt
    Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle.
    The Journal of biological chemistry 1994;269(16):11707-13.
  • 1994: G Asins; D Serra; F G Hegardt
    The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver.
    Biochemical pharmacology 1994;47(8):1373-9.
  • 1994: G Asins; J L Rosa; D Serra; G Gil-Gómez; J Ayté; R Bartrons; A Tauler; F G Hegardt
    Gene expression of enzymes regulating ketogenesis and fatty acid metabolism in regenerating rat liver.
    The Biochemical journal 1994;299 ( Pt 1)():65-9.
  • 1994: A Valera; M Pelegrin; G Asins; C Fillat; J Sabater; A Pujol; F G Hegardt; F Bosch
    Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis.
    The Journal of biological chemistry 1994;269(9):6267-70.
  • 1993: D Serra; N Casals; G Asins; T Royo; C J Ciudad; F G Hegardt
    Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes.
    Archives of biochemistry and biophysics 1993;307(1):40-5.
  • 1993: J Ayté; G Gil-Gómez; F G Hegardt
    Methylation of the regulatory region of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene leads to its transcriptional inactivation.
    The Biochemical journal 1993;295 ( Pt 3)():807-12.
  • 1993: J Martínez-González; C Buesa; M D Piulachs; X Bellés; F G Hegardt
    3-Hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression.
    European journal of biochemistry / FEBS 1993;217(2):691-9.
  • 1993: T Royo; M J Pedragosa; J Ayté; G Gil-Gómez; S Vilaró; F G Hegardt
    Testis and ovary express the gene for the ketogenic mitochondrial 3- hydroxy-3-methylglutaryl-CoA synthase.
    Journal of lipid research 1993;34(9):1636.
  • 1993: T Royo; M J Pedragosa; J Ayté; G Gil-Gómez; S Vilaró; F G Hegardt
    Testis and ovary express the gene for the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
    Journal of lipid research 1993;34(6):867-74.
  • 1993: G Gil-Gómez; J Ayté; F G Hegardt
    The rat mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A-synthase gene contains elements that mediate its multihormonal regulation and tissue specificity.
    European journal of biochemistry / FEBS 1993;213(2):773-9.
  • 1993: J Martinez-Gonzalez; C Buesa; M D Piulachs; X Belles; F G Hegardt
    Molecular cloning, developmental pattern and tissue expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the cockroach Blattella germanica.
    European journal of biochemistry / FEBS 1993;213(1):233-41.
  • 1993: D Serra; G Asins; F G Hegardt
    Ketogenic mitochondrial 3-hydroxy 3-methylglutaryl-CoA synthase gene expression in intestine and liver of suckling rats.
    Archives of biochemistry and biophysics 1993;301(2):445-8.
  • 1993: J Ayté; G Gil-Gómez; F G Hegardt
    Structural characterization of the 3' noncoding region of the gene encoding rat mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase.
    Gene 1993;123(2):267-70.
  • 1993: T Royo; D Haro; F G Hegardt
    Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.
    The Biochemical journal 1993;289 ( Pt 2)():557-60.
  • 1992: N Casals; N Roca; M Guerrero; G Gil-Gómez; J Ayté; C J Ciudad; F G Hegardt
    Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis.
    The Biochemical journal 1992;283 ( Pt 1)():261-4.
  • 1991: T Royo; J Ayté; F Albericio; E Giralt; D Haro; F G Hegardt
    Diurnal rhythm of rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase.
    The Biochemical journal 1991;280 ( Pt 1)():61-4.
  • 1991: G Gil-Gómez; P F Marrero; D Haro; J Ayté; F G Hegardt
    Characterization of the gene encoding the 10 kDa polypeptide of photosystem II from Arabidopsis thaliana.
    Plant molecular biology 1991;17(3):517-22.
  • 1991: G Asins; D Serra; F G Hegardt
    Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.
    Journal of lipid research 1991;32(9):1391-401.
  • 1990: J Ayté; G Gil-Gómez; F G Hegardt
    Nucleotide sequence of a rat liver cDNA encoding the cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.
    Nucleic acids research 1990;18(12):3642.
  • 1990: D Serra; G Asins; F G Hegardt
    Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3-hydroxy-3-methylglutaryl CoA reductase is the substrate.
    Journal of lipid research 1990;31(5):919-26.
  • 1990: J Ayté; G Gil-Gómez; D Haro; P F Marrero; F G Hegardt
    Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.
    Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3874-8.
  • 1990: D Haro; P F Marrero; J Ayté; F G Hegardt
    Identification of a cholesterol-regulated 180-kDa microsomal protein in rat hepatocytes.
    European journal of biochemistry / FEBS 1990;188(1):123-9.
  • 1989: C Caelles; A Ferrer; L Balcells; F G Hegardt; A Boronat
    Isolation and structural characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Plant molecular biology 1989;13(6):627-38.
  • 1989: D Serra; G Asins; V E Calvet; F G Hegardt
    Purification and properties of a protein inhibitor that inhibits phosphatase 2A activity when hydroxymethylglutaryl coenzyme A reductase is the substrate.
    The Journal of biological chemistry 1989;264(25):14681-5.
  • 1987: A Ferrer; C Caelles; F G Hegardt
    Reaction of 5'-p-fluorosulfonylbenzoyladenosine with the catalytic and AMP allosteric sites of microsomal HMG-CoA reductase kinase.
    Biochemical and biophysical research communications 1987;148(3):1009-16.
  • 1987: A Ferrer; C Caelles; N Massot; F G Hegardt
    Affinity labeling of the catalytic and AMP allosteric sites of 3-hydroxy-3-methylglutaryl-coenzyme A reductase kinase by 5'-p-fluorosulfonylbenzoyladenosine.
    The Journal of biological chemistry 1987;262(28):13507-12.
  • 1987: A Ferrer; C Caelles; N Massot; F G Hegardt
    Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.
    Biological chemistry Hoppe-Seyler 1987;368(3):249-57.
  • 1986: P F Marrero; D Haro; F G Hegardt
    Phosphorylation of HMG-CoA reductase induced by mevalonate accelerates its rate of degradation in isolated rat hepatocytes.
    FEBS letters 1986;197(1-2):183-6.
  • 1985: A Ferrer; C Caelles; N Massot; F G Hegardt
    Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.
    Biochemical and biophysical research communications 1985;132(2):497-504.
  • 1985: D Haro; P F Marrero; F G Hegardt
    Rat liver HMG CoA reductase, a glycoprotein of the endoplasmic reticulum, is in equilibrium between monomeric and dimeric forms.
    Biochemical and biophysical research communications 1985;132(2):598-604.
  • 1985: V E Calvet; G Gil; F G Hegardt
    Modulation of rat liver hydroxymethylglutaryl-CoA reductase by protein phosphatases: purification of nonspecific hydroxymethylglutaryl-CoA reductase phosphatases.
    Archives of biochemistry and biophysics 1985;236(2):753-65.
  • 1984: M Sitges; G Gil; F G Hegardt
    Partial purification from rat liver microsomes of three native protein phosphatases with activity towards HMG-CoA reductase.
    Journal of lipid research 1984;25(5):497-506.
  • 1983: F G Hegardt; G Gil; V E Calvet
    Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids.
    Journal of lipid research 1983;24(7):821-30.
  • 1982: G Gil; V E Calvet; A Ferrer; F G Hegardt
    Inactivation and reactivation of rat liver 3-hydroxy-3-methylglutaryl-CoA-reductase phosphatases: effect of phosphate, pyrophosphate and divalent cations.
    Hoppe-Seyler's Zeitschrift für physiologische Chemie 1982;363(10):1217-24.
  • 1982: E Font; M Sitges; F G Hegardt
    Multiple phosphorylation of rat liver 3-hydroxy 3-methylglutaryl coenzyme A reductase.
    Biochemical and biophysical research communications 1982;105(2):705-10.
  • 1982: G Gil; F G Hegardt
    Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver.
    Archives of biochemistry and biophysics 1982;214(1):192-8.
  • 1981: G Gil; M Sitges; F G Hegardt
    Preparation of highly radioactive homogeneous 32P-labeled hydroxymethylglutaryl coenzyme A reductase from rat liver.
    Archives of biochemistry and biophysics 1981;210(1):224-9.
  • 1980: G Gil; M Sitges; J Bové; F G Hegardt
    Phosphorylation--dephosphorylation of rat liver 3-hydroxy 3-methylglutaryl coenzyme A reductase associated with changes in activity.
    FEBS letters 1980;110(2):195-9.
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