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Fausto Hegardt
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42
Asins, Guillermina
41
Serra, Dolors
23
Casals, Núria
23
Haro, Diego
15
Marrero, Pedro
14
Gómez-Puertas, Paulino
13
Pié, Juan
10
López-Viñas, Eduardo
9
Buesa, Carlos
8
Morillas, Montserrat
7
Ortiz, José
7
Mascaró, Cristina
7
Caudevilla, C
7
Puisac, Beatriz
6
Vilaró, Senén
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All Publications
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2009: Noland Robert C; Koves Timothy R; Seiler Sarah E; Lum Helen; Lust Robert M; Ilkayeva Olga; Stevens Robert D; Hegardt Fausto G; Muoio Deborah M
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
The Journal of biological chemistry 2009;284(34):22840-52.
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2009: Menao Sebastián; López-Viñas Eduardo; Mir Cecilia; Puisac Beatriz; Gratacós Esther; Arnedo María; Carrasco Patricia; Moreno Susana; Ramos Mónica; Gil María Concepción; Pié Angeles; Ribes Antonia; Pérez-Cerda Celia; Ugarte Magdalena; Clayton Peter T; Korman Stanley H; Serra Dolors; Asins Guillermina; Ramos Feliciano J; Gómez-Puertas Paulino; Hegardt Fausto G; Casals Nuria; Pié Juan
Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria.
Human mutation 2009;30(3):E520-9.
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2009: Mera Paula; Bentebibel Assia; López-Viñas Eduardo; Cordente Antonio G; Gurunathan Chandrashekaran; Sebastián David; Vázquez Irene; Herrero Laura; Ariza Xavier; Gómez-Puertas Paulino; Asins Guillermina; Serra Dolors; García Jordi; Hegardt Fausto G
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
Biochemical pharmacology 2009;77(6):1084-95.
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2008: Sierra Adriana Y; Gratacós Esther; Carrasco Patricia; Clotet Josep; Ureña Jesús; Serra Dolors; Asins Guillermina; Hegardt Fausto G; Casals Núria
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.
The Journal of biological chemistry 2008;283(11):6878-85.
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2007: Pié Juan; López-Viñas Eduardo; Puisac Beatriz; Menao Sebastián; Pié Angeles; Casale Cesar; Ramos Feliciano J; Hegardt Fausto G; Gómez-Puertas Paulino; Casals Núria
Molecular genetics of HMG-CoA lyase deficiency.
Molecular genetics and metabolism 2007;92(3):198-209.
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2007: Jáuregui Olga; Sierra Adriana Y; Carrasco Patricia; Gratacós Esther; Hegardt Fausto G; Casals Núria
A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.
Analytica chimica acta 2007;599(1):1-6.
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2007: Carrasco Patricia; Menao Sebastian; López-Viñas Eduardo; Santpere Gabriel; Clotet Josep; Sierra Adriana Y; Gratacós Esther; Puisac Beatriz; Gómez-Puertas Paulino; Hegardt Fausto G; Pie Juan; Casals Núria
C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.
Molecular genetics and metabolism 2007;91(2):120-7.
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2007: López-Viñas Eduardo; Bentebibel Assia; Gurunathan Chandrashekaran; Morillas Montserrat; de Arriaga Dolores; Serra Dolors; Asins Guillermina; Hegardt Fausto G; Gómez-Puertas Paulino
Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.
The Journal of biological chemistry 2007;282(25):18212-24.
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2007: Guo Wen; Pirtskhalava Tamar; Tchkonia Tamara; Xie Weisheng; Thomou Thomas; Han Jianrong; Wang Tong; Wong Siu; Cartwright Andrew; Hegardt Fausto G; Corkey Barbara E; Kirkland James L
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
American journal of physiology. Endocrinology and metabolism 2007;292(4):E1041-51.
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2007: Sebastián David; Herrero Laura; Serra Dolors; Asins Guillermina; Hegardt Fausto G
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E677-86.
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2007: Cordente Antonio G; Swiegers Jan H; Hegardt Fausto G; Pretorius Isak S
Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae.
FEMS microbiology letters 2007;267(2):159-66.
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2006: Cordente Antonio G; López-Viñas Eduardo; Vázquez María Irene; Gómez-Puertas Paulino; Asins Guillermina; Serra Dolors; Hegardt Fausto G
Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.
Biochemistry 2006;45(19):6133-41.
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2006: Bentebibel Assia; Sebastián David; Herrero Laura; López-Viñas Eduardo; Serra Dolors; Asins Guillermina; Gómez-Puertas Paulino; Hegardt Fausto G
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.
Biochemistry 2006;45(14):4339-50.
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2006: Aledo R; Mir C; Dalton R N; Turner C; Pié J; Hegardt F G; Casals N; Champion M P
Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
Journal of inherited metabolic disease 2006;29(1):207-11.
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2006: Mir C; Lopez-Viñas E; Aledo R; Puisac B; Rizzo C; Dionisi-Vici C; Deodato F; Pié J; Gomez-Puertas P; Hegardt F G; Casals N
A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase.
Journal of inherited metabolic disease 2006;29(1):64-70.
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2005: Puisac Beatriz; López-Viñas Eduardo; Moreno Susana; Mir Cecilia; Pérez-Cerdá Celia; Menao Sebastián; Lluch Dolores; Pié Angeles; Gómez-Puertas Paulino; Casals Nuria; Ugarte Magdalena; Hegardt Faustog; Pié Juan
Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL.
Biophysical chemistry 2005;115(2-3):241-5.
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2005: Herrero Laura; Rubí Blanca; Sebastián David; Serra Dolors; Asins Guillermina; Maechler Pierre; Prentki Marc; Hegardt Fausto G
Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.
Diabetes 2005;54(2):462-71.
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2004: Cordente Antonio G; López-Viñas Eduardo; Vázquez María Irene; Swiegers Jan H; Pretorius Isak S; Gómez-Puertas Paulino; Hegardt Fausto G; Asins Guillermina; Serra Dolors
Redesign of carnitine acetyltransferase specificity by protein engineering.
The Journal of biological chemistry 2004;279(32):33899-908.
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2004: Morillas Montserrat; López-Viñas Eduardo; Valencia Alfonso; Serra Dolors; Gómez-Puertas Paulino; Hegardt Fausto G; Asins Guillermina
Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.
The Biochemical journal 2004;379(Pt 3):777-84.
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2003: Pie J; Casals N; Puisac B; Hegardt F G
Molecular basis of 3-hydroxy-3-methylglutaric aciduria.
Journal of physiology and biochemistry 2003;59(4):311-21.
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2003: Casals Núria; Gómez-Puertas Paulino; Pié Juan; Mir Cecilia; Roca Ramón; Puisac Beatriz; Aledo Rosa; Clotet Josep; Menao Sebastián; Serra Dolors; Asins Guillermina; Till Jacqueline; Elias-Jones Alun C; Cresto Juan C; Chamoles Nestor A; Abdenur Jose E; Mayatepek Ertan; Besley Guy; Valencia Alfonso; Hegardt Fausto G
Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.
The Journal of biological chemistry 2003;278(31):29016-23.
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2003: Morillas Montserrat; Gómez-Puertas Paulino; Bentebibel Assia; Sellés Eva; Casals Nuria; Valencia Alfonso; Hegardt Fausto G; Asins Guillermina; Serra Dolors
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
The Journal of biological chemistry 2003;278(11):9058-63.
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2002: Lang Corinne; Berardi Simona; Schäfer Markus; Serra Dolors; Hegardt Fausto G; Krähenbühl Lukas; Krähenbühl Stephan
Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction.
Journal of hepatology 2002;37(5):564-71.
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2002: Zschocke Johannes; Penzien Johannes M; Bielen Rainer; Casals Núria; Aledo Rosa; Pié Juan; Hoffmann Georg F; Hegardt Fausto G; Mayatepek Ertan
The diagnosis of mitochondrial HMG-CoA synthase deficiency.
The Journal of pediatrics 2002;140(6):778-80.
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2002: Rubí Blanca; Antinozzi Peter A; Herrero Laura; Ishihara Hisamitsu; Asins Guillermina; Serra Dolors; Wollheim Claes B; Maechler Pierre; Hegardt Fausto G
Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.
The Biochemical journal 2002;364(Pt 1):219-26.
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2002: Morillas Montserrat; Gómez-Puertas Paulino; Rubí Blanca; Clotet Josep; Ariño Joaquín; Valencia Alfonso; Hegardt Fausto G; Serra Dolors; Asins Guillermina
Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.
The Journal of biological chemistry 2002;277(13):11473-80.
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2001: Morillas M; Gómez-Puertas P; Roca R; Serra D; Asins G; Valencia A; Hegardt F G
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.
The Journal of biological chemistry 2001;276(48):45001-8.
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2001: Rubi B; Ishihara H; Hegardt F G; Wollheim C B; Maechler P
GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.
The Journal of biological chemistry 2001;276(39):36391-6.
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2001: Aledo R; Zschocke J; Pié J; Mir C; Fiesel S; Mayatepek E; Hoffmann G F; Casals N; Hegardt F G
Genetic basis of mitochondrial HMG-CoA synthase deficiency.
Human genetics 2001;109(1):19-23.
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2001: Caudevilla C; Codony C; Serra D; Plasencia G; Román R; Graessmann A; Asins G; Bach-Elias M; Hegardt F G
Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.
Nucleic acids research 2001;29(14):3108-15.
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2001: Codony C; Guil S; Caudevilla C; Serra D; Asins G; Graessmann A; Hegardt F G; Bach-Elias M
Modulation in vitro of H-ras oncogene expression by trans-splicing.
Oncogene 2001;20(28):3683-94.
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2001: Hegardt F G; Bach M; Asins G; Caudevilla C; Morillas M; Codony C; Serra D
Post-transcriptional regulation of rat carnitine octanoyltransferase.
Biochemical Society transactions 2001;29(Pt 2):316-20.
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2001: Casals N; Buesa C; Marrero P F; Belles X; Hegardt F G
3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene.
Insect biochemistry and molecular biology 2001;31(4-5):425-33.
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2001: Nicot C; Hegardt F G; Woldegiorgis G; Haro D; Marrero P F
Pig liver carnitine palmitoyltransferase I, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes.
Biochemistry 2001;40(7):2260-6.
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2001: Barrero M J; Alho C S; Ortiz J A; Hegardt F G; Haro D; Marrero P F
Low activity of mitochondrial HMG-CoA synthase in liver of starved piglets is due to low levels of protein despite high mRNA levels.
Archives of biochemistry and biophysics 2001;385(2):364-71.
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2001: Miliar A; Serra D; Casaroli R; Vilaró S; Asins G; Hegardt F G
Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats.
Archives of biochemistry and biophysics 2001;385(2):283-9.
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2001: Lopez J M; Hegardt F G; Haro D
Differential expression of cytosolic and mitochondrial 3-hydroxy-3-methylglutaryl CoA synthases during adipocyte differentiation.
Molecular and cellular biochemistry 2001;217(1-2):57-66.
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2001: Lang C; Schäfer M; Serra D; Hegardt F; Krähenbühl L; Krähenbühl S
Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism.
Journal of lipid research 2001;42(1):22-30.
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2000: Morillas M; Clotet J; Rubí B; Serra D; Ariño J; Hegardt F G; Asins G
Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.
The Biochemical journal 2000;351 Pt 2():495-502.
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2000: Mascaró C; Nadal A; Hegardt F G; Marrero P F; Haro D
Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis.
The Biochemical journal 2000;350 Pt 3():785-90.
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2000: Mascaró C; Ortiz J A; Ramos M M; Haro D; Hegardt F G
Sterol regulatory element binding protein-mediated effect of fluvastatin on cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase transcription.
Archives of biochemistry and biophysics 2000;374(2):286-92.
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2000: Morillas M; Clotet J; Rubí B; Serra D; Asins G; Ariño J; Hegardt F G
Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver.
FEBS letters 2000;466(1):183-6.
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2000: Eggers A; Caudevilla C; Asins G; Hegardt F G; Serra D
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells.
The Biochemical journal 2000;345 Pt 2():201-6.
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1999: Madsen L; Garras A; Asins G; Serra D; Hegardt F G; Berge R K
Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation.
Biochemical pharmacology 1999;57(9):1011-9.
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1999: Hegardt F G
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis.
The Biochemical journal 1999;338 ( Pt 3)():569-82.
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1999: Ortiz J A; Mallolas J; Nicot C; Bofarull J; Rodríguez J C; Hegardt F G; Haro D; Marrero P F
Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element.
The Biochemical journal 1999;337 ( Pt 2)():329-35.
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1999: Caudevilla C; Serra D; Miliar A; Codony C; Asins G; Bach M; Hegardt F G
Processing of carnitine octanoyltransferase pre-mRNAs by cis and trans-splicing.
Advances in experimental medicine and biology 1999;466():95-102.
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1999: Mascaró C; Acosta E; Ortiz J A; Rodríguez J C; Marrero P F; Hegardt F G; Haro D
Characterization of a response element for peroxisomal proliferator activated receptor (PPRE) in human muscle-type carnitine palmitoyltransferase I.
Advances in experimental medicine and biology 1999;466():79-85.
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1999: Berge R K; Garras A; Asins G; Serra D; Hegardt F G; Madsen L
Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase and carnitine palmitoyltransferase II are potential control sites of hepatic ketogenesis under conditions of peroxisome proliferation.
Lipids 1999;34 Suppl():S163.
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1998: Hegardt F G
Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis.
Biochimie 1998;80(10):803-6.
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1998: Zapater N; Pié J; Lloberas J; Rolland M O; Leroux B; Vidailhet M; Divry P; Hegardt F G; Casals N
Two missense point mutations in different alleles in the 3-hydroxy-3-methylglutaryl coenzyme A lyase gene produce 3-hydroxy-3-methylglutaric aciduria in a French patient.
Archives of biochemistry and biophysics 1998;358(2):197-203.
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1998: Caudevilla C; Serra D; Miliar A; Codony C; Asins G; Bach M; Hegardt F G
Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12185-90.
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1998: Mascaró C; Acosta E; Ortiz J A; Marrero P F; Hegardt F G; Haro D
Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor.
The Journal of biological chemistry 1998;273(15):8560-3.
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1998: Arias G; Asins G; Hegardt F G; Serra D
The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
Molecular and cellular biochemistry 1998;178(1-2):325-33.
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1998: Rodríguez J C; Ortiz J A; Hegardt F G; Haro D
The hepatocyte nuclear factor 4 (HNF-4) represses the mitochondrial HMG-CoA synthase gene.
Biochemical and biophysical research communications 1998;242(3):692-6.
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1998: Casale C H; Casals N; Pié J; Zapater N; Pérez-Cerdá C; Merinero B; Martínez-Pardo M; García-Peñas J J; García-Gonzalez J M; Lama R; Poll-The B T; Smeitink J A; Wanders R J; Ugarte M; Hegardt F G
A nonsense mutation in the exon 2 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing three mature mRNAs is the main cause of 3-hydroxy-3-methylglutaric aciduria in European Mediterranean patients.
Archives of biochemistry and biophysics 1998;349(1):129-37.
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1997: Casals N; Pié J; Casale C H; Zapater N; Ribes A; Castro-Gago M; Rodriguez-Segade S; Wanders R J; Hegardt F G
A two-base deletion in exon 6 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3-hydroxy-3-methylglutaric aciduria.
Journal of lipid research 1997;38(11):2303-13.
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1997: Rodríguez J C; Ortiz J A; Hegardt F G; Haro D
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene.
The Biochemical journal 1997;326 ( Pt 2)():587-92.
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1997: Cabañó J; Buesa C; Hegardt F G; Marrero P F
Catalytic properties of recombinant 3-hydroxy-3-methylglutaryl coenzyme A synthase-1 from Blattella germanica.
Insect biochemistry and molecular biology 1997;27(6):499-505.
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1997: Adams S H; Alho C S; Asins G; Hegardt F G; Marrero P F
Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet.
The Biochemical journal 1997;324 ( Pt 1)():65-73.
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1997: Pié J; Casals N; Casale C H; Buesa C; Mascaró C; Barceló A; Rolland M O; Zabot T; Haro D; Eyskens F; Divry P; Hegardt F G
A nonsense mutation in the 3-hydroxy-3-methylglutaryl-CoA lyase gene produces exon skipping in two patients of different origin with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
The Biochemical journal 1997;323 ( Pt 2)():329-35.
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1997: Arias G; Asins G; Hegardt F G; Serra D
The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
Archives of biochemistry and biophysics 1997;340(2):287-98.
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1996: Buesa C; Pié J; Barceló A; Casals N; Mascaró C; Casale C H; Haro D; Duran M; Smeitink J A; Hegardt F G
Aberrantly spliced mRNAs of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene with a donor splice-site point mutation produce hereditary HL deficiency.
Journal of lipid research 1996;37(11):2420-32.
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1996: Casals N; Buesa C; Piulachs M D; Cabañó J; Marrero P F; Bellés X; Hegardt F G
Coordinated expression and activity of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase in the fat body of Blattella germanica (L.) during vitellogenesis.
Insect biochemistry and molecular biology 1996;26(8-9):837-43.
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1996: Asins G; Serra D; Miliar A; Caudevilla C; Matas R; Arias G; Hegardt F G
Developmental changes in the phospho(enol)pyruvate carboxykinase gene expression in small intestine and liver of suckling rats.
Archives of biochemistry and biophysics 1996;329(1):82-6.
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1996: Serra D; Bellido D; Asins G; Arias G; Vilaró S; Hegardt F G
The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control.
European journal of biochemistry / FEBS 1996;237(1):16-24.
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1996: Serra D; Fillat C; Matas R; Bosch F; Hegardt F G
Tissue-specific expression and dietary regulation of chimeric mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase/human growth hormone gene in transgenic mice.
The Journal of biological chemistry 1996;271(13):7529-34.
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1995: Martinez-Gonzalez J; Hegardt F G
Characterization of a cDNA encoding a cytosolic peptidylprolyl cis-trans-isomerase from Blattella germanica.
European journal of biochemistry / FEBS 1995;234(1):284-92.
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1995: Hegardt F G; Serra D; Asins G
Influence of etomoxir on the expression of several genes in liver, testis and heart.
General pharmacology 1995;26(5):897-904.
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1995: Arias G; Matas R; Asins G; Hegardt F G; Serra D
The effect of fasting and insulin treatment on carnitine palmitoyl transferase I and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase mRNA levels in liver from suckling rats.
Biochemical Society transactions 1995;23(3):493S.
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1995: Hegardt F G
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in liver and intestine from the rat.
Biochemical Society transactions 1995;23(3):486-90.
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1995: Mascaró C; Buesa C; Ortiz J A; Haro D; Hegardt F G
Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
Archives of biochemistry and biophysics 1995;317(2):385-90.
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1995: Asins G; Serra D; Arias G; Hegardt F G
Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats.
The Biochemical journal 1995;306 ( Pt 2)():379-84.
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1995: Royo T; Pedragosa M J; Ayté J; Gil-Gómez G; Vilaró S; Hegardt F G
Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver.
Journal of cellular physiology 1995;162(1):103-9.
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1994: Ortiz J A; Gil-Gómez G; Casaroli-Marano R P; Vilaró S; Hegardt F G; Haro D
Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate.
The Journal of biological chemistry 1994;269(46):28523-6.
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1994: Rodríguez J C; Gil-Gómez G; Hegardt F G; Haro D
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
The Journal of biological chemistry 1994;269(29):18767-72.
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1994: Martínez-González J; Hegardt F G
Cytochrome c oxidase subunit I from the cockroach Blattella germanica: cloning, developmental pattern and tissue expression.
Insect biochemistry and molecular biology 1994;24(6):619-26.
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1994: Asins G; Serra D; Hegardt F G
The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver.
Biochemical pharmacology 1994;47(8):1373-9.
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1994: Asins G; Rosa J L; Serra D; Gil-Gómez G; Ayté J; Bartrons R; Tauler A; Hegardt F G
Gene expression of enzymes regulating ketogenesis and fatty acid metabolism in regenerating rat liver.
The Biochemical journal 1994;299 ( Pt 1)():65-9.
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1994: Buesa C; Martínez-Gonzalez J; Casals N; Haro D; Piulachs M D; Bellés X; Hegardt F G
Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle.
The Journal of biological chemistry 1994;269(16):11707-13.
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1994: Valera A; Pelegrin M; Asins G; Fillat C; Sabater J; Pujol A; Hegardt F G; Bosch F
Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis.
The Journal of biological chemistry 1994;269(9):6267-70.
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1993: Serra D; Casals N; Asins G; Royo T; Ciudad C J; Hegardt F G
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes.
Archives of biochemistry and biophysics 1993;307(1):40-5.
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1993: Ayté J; Gil-Gómez G; Hegardt F G
Methylation of the regulatory region of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene leads to its transcriptional inactivation.
The Biochemical journal 1993;295 ( Pt 3)():807-12.
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1993: Martínez-González J; Buesa C; Piulachs M D; Bellés X; Hegardt F G
3-Hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression.
European journal of biochemistry / FEBS 1993;217(2):691-9.
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1993: Royo T; Pedragosa M J; Ayté J; Gil-Gómez G; Vilaró S; Hegardt F G
Testis and ovary express the gene for the ketogenic mitochondrial 3- hydroxy-3-methylglutaryl-CoA synthase.
Journal of lipid research 1993;34(9):1636.
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1993: Royo T; Pedragosa M J; Ayté J; Gil-Gómez G; Vilaró S; Hegardt F G
Testis and ovary express the gene for the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
Journal of lipid research 1993;34(6):867-74.
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1993: Martinez-Gonzalez J; Buesa C; Piulachs M D; Belles X; Hegardt F G
Molecular cloning, developmental pattern and tissue expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of the cockroach Blattella germanica.
European journal of biochemistry / FEBS 1993;213(1):233-41.
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1993: Gil-Gómez G; Ayté J; Hegardt F G
The rat mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A-synthase gene contains elements that mediate its multihormonal regulation and tissue specificity.
European journal of biochemistry / FEBS 1993;213(2):773-9.
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1993: Serra D; Asins G; Hegardt F G
Ketogenic mitochondrial 3-hydroxy 3-methylglutaryl-CoA synthase gene expression in intestine and liver of suckling rats.
Archives of biochemistry and biophysics 1993;301(2):445-8.
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1993: Ayté J; Gil-Gómez G; Hegardt F G
Structural characterization of the 3' noncoding region of the gene encoding rat mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Gene 1993;123(2):267-70.
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1993: Royo T; Haro D; Hegardt F G
Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.
The Biochemical journal 1993;289 ( Pt 2)():557-60.
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1992: Casals N; Roca N; Guerrero M; Gil-Gómez G; Ayté J; Ciudad C J; Hegardt F G
Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis.
The Biochemical journal 1992;283 ( Pt 1)():261-4.
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1991: Royo T; Ayté J; Albericio F; Giralt E; Haro D; Hegardt F G
Diurnal rhythm of rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase.
The Biochemical journal 1991;280 ( Pt 1)():61-4.
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1991: Gil-Gómez G; Marrero P F; Haro D; Ayté J; Hegardt F G
Characterization of the gene encoding the 10 kDa polypeptide of photosystem II from Arabidopsis thaliana.
Plant molecular biology 1991;17(3):517-22.
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1991: Asins G; Serra D; Hegardt F G
Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.
Journal of lipid research 1991;32(9):1391-401.
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1990: Ayté J; Gil-Gómez G; Hegardt F G
Nucleotide sequence of a rat liver cDNA encoding the cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Nucleic acids research 1990;18(12):3642.
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1990: Serra D; Asins G; Hegardt F G
Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3-hydroxy-3-methylglutaryl CoA reductase is the substrate.
Journal of lipid research 1990;31(5):919-26.
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1990: Ayté J; Gil-Gómez G; Haro D; Marrero P F; Hegardt F G
Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3874-8.
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1990: Haro D; Marrero P F; Ayté J; Hegardt F G
Identification of a cholesterol-regulated 180-kDa microsomal protein in rat hepatocytes.
European journal of biochemistry / FEBS 1990;188(1):123-9.
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1989: Caelles C; Ferrer A; Balcells L; Hegardt F G; Boronat A
Isolation and structural characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Plant molecular biology 1989;13(6):627-38.
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1989: Serra D; Asins G; Calvet V E; Hegardt F G
Purification and properties of a protein inhibitor that inhibits phosphatase 2A activity when hydroxymethylglutaryl coenzyme A reductase is the substrate.
The Journal of biological chemistry 1989;264(25):14681-5.
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1987: Ferrer A; Caelles C; Hegardt F G
Reaction of 5'-p-fluorosulfonylbenzoyladenosine with the catalytic and AMP allosteric sites of microsomal HMG-CoA reductase kinase.
Biochemical and biophysical research communications 1987;148(3):1009-16.
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1987: Ferrer A; Caelles C; Massot N; Hegardt F G
Affinity labeling of the catalytic and AMP allosteric sites of 3-hydroxy-3-methylglutaryl-coenzyme A reductase kinase by 5'-p-fluorosulfonylbenzoyladenosine.
The Journal of biological chemistry 1987;262(28):13507-12.
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1987: Ferrer A; Caelles C; Massot N; Hegardt F G
Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.
Biological chemistry Hoppe-Seyler 1987;368(3):249-57.
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1986: Marrero P F; Haro D; Hegardt F G
Phosphorylation of HMG-CoA reductase induced by mevalonate accelerates its rate of degradation in isolated rat hepatocytes.
FEBS letters 1986;197(1-2):183-6.
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1985: Ferrer A; Caelles C; Massot N; Hegardt F G
Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.
Biochemical and biophysical research communications 1985;132(2):497-504.
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1985: Haro D; Marrero P F; Hegardt F G
Rat liver HMG CoA reductase, a glycoprotein of the endoplasmic reticulum, is in equilibrium between monomeric and dimeric forms.
Biochemical and biophysical research communications 1985;132(2):598-604.
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1985: Calvet V E; Gil G; Hegardt F G
Modulation of rat liver hydroxymethylglutaryl-CoA reductase by protein phosphatases: purification of nonspecific hydroxymethylglutaryl-CoA reductase phosphatases.
Archives of biochemistry and biophysics 1985;236(2):753-65.
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1984: Sitges M; Gil G; Hegardt F G
Partial purification from rat liver microsomes of three native protein phosphatases with activity towards HMG-CoA reductase.
Journal of lipid research 1984;25(5):497-506.
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1983: Hegardt F G; Gil G; Calvet V E
Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids.
Journal of lipid research 1983;24(7):821-30.
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1982: Gil G; Calvet V E; Ferrer A; Hegardt F G
Inactivation and reactivation of rat liver 3-hydroxy-3-methylglutaryl-CoA-reductase phosphatases: effect of phosphate, pyrophosphate and divalent cations.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1982;363(10):1217-24.
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1982: Font E; Sitges M; Hegardt F G
Multiple phosphorylation of rat liver 3-hydroxy 3-methylglutaryl coenzyme A reductase.
Biochemical and biophysical research communications 1982;105(2):705-10.
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1982: Gil G; Hegardt F G
Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver.
Archives of biochemistry and biophysics 1982;214(1):192-8.
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1981: Gil G; Sitges M; Hegardt F G
Preparation of highly radioactive homogeneous 32P-labeled hydroxymethylglutaryl coenzyme A reductase from rat liver.
Archives of biochemistry and biophysics 1981;210(1):224-9.
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1980: Gil G; Sitges M; Bové J; Hegardt F G
Phosphorylation--dephosphorylation of rat liver 3-hydroxy 3-methylglutaryl coenzyme A reductase associated with changes in activity.
FEBS letters 1980;110(2):195-9.
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