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Ramanujan Hegde

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Publications

TOP 3
Monica C Rodrigo-Brenni; Ramanujan S Hegde
Design principles of protein biosynthesis-coupled quality control.
Agnes Basseville; Ramanujan S Hegde; Caterina Ierano; Robert W Robey; Akina Tamaki; Shana Trostel; Yvona Ward; Susan E Bates
Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter.
Ramanujan S Hegde; Robert J Keenan
Tail-anchored membrane protein insertion into the endoplasmic reticulum.

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All Publications

2012: Monica C Rodrigo-Brenni; Ramanujan S Hegde
Design principles of protein biosynthesis-coupled quality control.
Developmental cell 2012;23(5):896-907.
2012: Agnes Basseville; Ramanujan S Hegde; Caterina Ierano; Robert W Robey; Akina Tamaki; Shana Trostel; Yvona Ward; Susan E Bates
Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter.
Cancer research 2012;72(14):3642-51.
2011: Ramanujan S Hegde; Robert J Keenan
Tail-anchored membrane protein insertion into the endoplasmic reticulum.
Nature reviews. Molecular cell biology 2011;12(12):787-98.
2011: Sarah V Maifeld; Ajay Sharma; Jennifer L Garrison; Ramanujan S Hegde; Eric J Kunkel; Andrew L MacKinnon; Jack Taunton
Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.
Chemistry & biology 2011;18(9):1082-8.
2011: Malaiyalam Mariappan; Agnieszka Mateja; Elia Bove; Malgorzata Dobosz; Ramanujan S Hegde; Robert J Keenan
The mechanism of membrane-associated steps in tail-anchored protein insertion.
Nature 2011;477(7362):61-6.
2011: John Sherrill; Malaiyalam Mariappan; Pawel Dominik; Ramanujan S Hegde; Robert J Keenan
A conserved archaeal pathway for tail-anchored membrane protein insertion.
Traffic (Copenhagen, Denmark) 2011;12(9):1119-23.
2011: Tara Hessa; Malaiyalam Mariappan; Ajay Sharma; Heather D Eshleman; Erik Gutierrez; Ramanujan S Hegde
Protein targeting and degradation are coupled for elimination of mislocalized proteins.
Nature 2011;475(7356):394-7.
2011: Sichen Shao; Ramanujan S Hegde
A flip turn for membrane protein insertion.
Cell 2011;146(1):13-5.
2011: Oishee Chakrabarti; Neena S Rane; Ramanujan S Hegde
Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins.
Molecular biology of the cell 2011;22(10):1625-37.
2011: Sichen Shao; Ramanujan S Hegde
Membrane protein insertion at the endoplasmic reticulum.
Annual review of cell and developmental biology 2011;27():25-56.
2011: Richard I Morimoto; Arnold J M Driessen; Ramanujan S Hegde; Thomas Langer
The life of proteins: the good, the mostly good and the ugly.
Nature structural & molecular biology 2011;18(1):1-4.
2010: Amy B Emerman; Zai-Rong Zhang; Oishee Chakrabarti; Ramanujan S Hegde
Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.
Molecular biology of the cell 2010;21(24):4325-37.
2010: Malaiyalam Mariappan; Xingzhe Li; Sandra Stefanovic; Ajay Sharma; Agnieszka Mateja; Robert J Keenan; Ramanujan S Hegde
A ribosome-associating factor chaperones tail-anchored membrane proteins.
Nature 2010;466(7310):1120-4.
2010: Ramanujan S Hegde; Hidde L Ploegh
Quality and quantity control at the endoplasmic reticulum.
Current opinion in cell biology 2010;22(4):437-46.
2010: D Thomas Rutkowski; Ramanujan S Hegde
Regulation of basal cellular physiology by the homeostatic unfolded protein response.
The Journal of cell biology 2010;189(5):783-94.
2010: Neena S Rane; Oishee Chakrabarti; Lionel Feigenbaum; Ramanujan S Hegde
Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.
The Journal of cell biology 2010;188(4):515-26.
2010: Ajay Sharma; Malaiyalam Mariappan; Suhila Appathurai; Ramanujan S Hegde
In vitro dissection of protein translocation into the mammalian endoplasmic reticulum.
Methods in molecular biology (Clifton, N.J.) 2010;619():339-63.
2009: Agnieszka Mateja; Anna Szlachcic; Maureen E Downing; Malgorzata Dobosz; Malaiyalam Mariappan; Ramanujan S Hegde; Robert J Keenan
The structural basis of tail-anchored membrane protein recognition by Get3.
Nature 2009;461(7262):361-6.
2009: Orsolya Polgar; Lilangi S Ediriwickrema; Robert W Robey; Ajay Sharma; Ramanujan S Hegde; Yongfu Li; Di Xia; Yvona Ward; Michael Dean; Csilla Ozvegy-Laczka; Balázs Sarkadi; Susan E Bates
Arginine 383 is a crucial residue in ABCG2 biogenesis.
Biochimica et biophysica acta 2009;1788(7):1434-43.
2009: Oishee Chakrabarti; Ramanujan S Hegde
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.
Cell 2009;137(6):1136-47.
2009: Aarthi Ashok; Ramanujan S Hegde
Selective processing and metabolism of disease-causing mutant prion proteins.
PLoS pathogens 2009;5(6):e1000479.
2009: Oishee Chakrabarti; Aarthi Ashok; Ramanujan S Hegde
Prion protein biosynthesis and its emerging role in neurodegeneration.
Trends in biochemical sciences 2009;34(6):287-95.
2008: Sang-Wook Kang; Ramanujan S Hegde
Lighting up the stressed ER.
Cell 2008;135(5):787-9.
2008: Neena S Rane; Sang-Wook Kang; Oishee Chakrabarti; Lionel Feigenbaum; Ramanujan S Hegde
Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.
Developmental cell 2008;15(3):359-70.
2008: Aarthi Ashok; Ramanujan S Hegde
Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation.
Molecular biology of the cell 2008;19(8):3463-76.
2008: Ramanujan S Hegde; Sang-Wook Kang
The concept of translocational regulation.
The Journal of cell biology 2008;182(2):225-32.
2008: Jean-François Ménétret; Ramanujan S Hegde; Mike Aguiar; Steven P Gygi; Eunyong Park; Tom A Rapoport; Christopher W Akey
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.
Structure (London, England : 1993) 2008;16(7):1126-37.
2007: Andrew L MacKinnon; Jennifer L Garrison; Ramanujan S Hegde; Jack Taunton
Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation.
Journal of the American Chemical Society 2007;129(47):14560-1.
2007: D Thomas Rutkowski; Sang-Wook Kang; Alan G Goodman; Jennifer L Garrison; Jack Taunton; Michael G Katze; Randal J Kaufman; Ramanujan S Hegde
The role of p58IPK in protecting the stressed endoplasmic reticulum.
Molecular biology of the cell 2007;18(9):3681-91.
2007: Hwei Ling Ong; Xibao Liu; Krasimira Tsaneva-Atanasova; Brij B Singh; Bidhan Bandyopadhyay; William D Swaim; James T Russell; Ramanujan S Hegde; Arthur Sherman; Indu S Ambudkar
Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store.
The Journal of biological chemistry 2007;282(16):12176-85.
2007: Sandra Stefanovic; Ramanujan S Hegde
Identification of a targeting factor for posttranslational membrane protein insertion into the ER.
Cell 2007;128(6):1147-59.
2007: Hwei Ling Ong; Xibao Liu; Ajay Sharma; Ramanujan S Hegde; Indu S Ambudkar
Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry.
Pflügers Archiv : European journal of physiology 2007;453(6):797-808.
2006: Sang-Wook Kang; Neena S Rane; Soo Jung Kim; Jennifer L Garrison; Jack Taunton; Ramanujan S Hegde
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.
Cell 2006;127(5):999-1013.
2006: Erik L Snapp; Ramanujan S Hegde
Rational design and evaluation of FRET experiments to measure protein proximities in cells.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2006;Chapter 17():Unit 17.9.
2006: Ramanujan S Hegde; Harris D Bernstein
The surprising complexity of signal sequences.
Trends in biochemical sciences 2006;31(10):563-71.
2006: Aarthi Ashok; Ramanujan S Hegde
Prions and retroviruses: an endosomal rendezvous?
EMBO reports 2006;7(7):685-7.
2006: Erik L Snapp; Ajay Sharma; Jennifer Lippincott-Schwartz; Ramanujan S Hegde
Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6536-41.
2005: Kelly L Shaffer; Ajay Sharma; Erik L Snapp; Ramanujan S Hegde
Regulation of protein compartmentalization expands the diversity of protein function.
Developmental cell 2005;9(4):545-54.
2005: Silvia Brambillasca; Monica Yabal; Paolo Soffientini; Sandra Stefanovic; Marja Makarow; Ramanujan S Hegde; Nica Borgese
Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition.
The EMBO journal 2005;24(14):2533-42.
2005: Jennifer L Garrison; Eric J Kunkel; Ramanujan S Hegde; Jack Taunton
A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.
Nature 2005;436(7048):285-9.
2005: Jean-François Ménétret; Ramanujan S Hegde; Sven U Heinrich; Preethi Chandramouli; Steven J Ludtke; Tom A Rapoport; Christopher W Akey
Architecture of the ribosome-channel complex derived from native membranes.
Journal of molecular biology 2005;348(2):445-57.
2005: Corinna G Levine; Devarati Mitra; Ajay Sharma; Carolyn L Smith; Ramanujan S Hegde
The efficiency of protein compartmentalization into the secretory pathway.
Molecular biology of the cell 2005;16(1):279-91.
2004: Neena S Rane; Jesse L Yonkovich; Ramanujan S Hegde
Protection from cytosolic prion protein toxicity by modulation of protein translocation.
The EMBO journal 2004;23(23):4550-9.
2004: Verena Karsten; Ramanujan S Hegde; Anthony P Sinai; Mei Yang; Keith A Joiner
Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii.
The Journal of biological chemistry 2004;279(25):26052-7.
2004: Yongli Zhang; Zhiqun Xi; Ramanujan S Hegde; Zippora Shakked; Donald M Crothers
Predicting indirect readout effects in protein-DNA interactions.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8337-41.
2004: Erik L Snapp; Gretchen A Reinhart; Brigitte A Bogert; Jennifer Lippincott-Schwartz; Ramanujan S Hegde
The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells.
The Journal of cell biology 2004;164(7):997-1007.
2004: Patrick Tremblay; Haydn L Ball; Kiyotoshi Kaneko; Darlene Groth; Ramanujan S Hegde; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Jiri G Safar
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
Journal of virology 2004;78(4):2088-99.
2003: Erik L Snapp; Ramanujan S Hegde; Maura Francolini; Francesca Lombardo; Sara Colombo; Emanuela Pedrazzini; Nica Borgese; Jennifer Lippincott-Schwartz
Formation of stacked ER cisternae by low affinity protein interactions.
The Journal of cell biology 2003;163(2):257-69.
2003: Ramanujan S Hegde; Neena S Rane
Prion protein trafficking and the development of neurodegeneration.
Trends in neurosciences 2003;26(7):337-9.
2003: Ryen D Fons; Brigitte A Bogert; Ramanujan S Hegde
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane.
The Journal of cell biology 2003;160(4):529-39.
2002: Soo Jung Kim; Ramanujan S Hegde
Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.
Molecular biology of the cell 2002;13(11):3775-86.
2002: Ramanujan S Hegde
Targeting and beyond: new roles for old signal sequences.
Molecular cell 2002;10(4):697-8.
2002: Vishwanath R Lingappa; D Thomas Rutkowski; Ramanujan S Hegde; Olaf S Andersen
Conformational control through translocational regulation: a new view of secretory and membrane protein folding.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(8):741-8.
2002: Soo Jung Kim; Devarati Mitra; Jeffrey R Salerno; Ramanujan S Hegde
Signal sequences control gating of the protein translocation channel in a substrate-specific manner.
Developmental cell 2002;2(2):207-17.
2001: Seong-Jin Kim; R Rahbar; Ramanujan S Hegde
Combinatorial control of prion protein biogenesis by the signal sequence and transmembrane domain.
The Journal of biological chemistry 2001;276(28):26132-40.
2001: D Thomas Rutkowski; Vishwanath R Lingappa; Ramanujan S Hegde
Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7823-8.
2000: James E Wilhelm; Ronald D Vale; Ramanujan S Hegde
Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13132-7.
1999: Ramanujan S Hegde; Patrick Tremblay; Darlene Groth; Stephen J DeArmond; Stanley B Prusiner; Vishwanath R Lingappa
Transmissible and genetic prion diseases share a common pathway of neurodegeneration.
Nature 1999;402(6763):822-6.
1999: Ramanujan S Hegde; Vishwanath R Lingappa
Regulation of protein biogenesis at the endoplasmic reticulum membrane.
Trends in cell biology 1999;9(4):132-7.
1998: Haim Rozenberg; Dov Rabinovich; Felix Frolow; Ramanujan S Hegde; Zippora Shakked
Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15194-9.
1998: Ramanujan S Hegde; S Voigt; Vishwanath R Lingappa
Regulation of protein topology by trans-acting factors at the endoplasmic reticulum.
Molecular cell 1998;2(1):85-91.
1998: Antonio Rusiñol; Ramanujan S Hegde; S L Chuck; Vishwanath R Lingappa; Jean E Vance
Translocational pausing of apolipoprotein B can be regulated by membrane lipid composition.
Journal of lipid research 1998;39(6):1287-94.
1998: Ramanujan S Hegde; S Voigt; T A Rapoport; Vishwanath R Lingappa
TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum.
Cell 1998;92(5):621-31.
1998: Ramanujan S Hegde; James A Mastrianni; Michael R Scott; Kathryn DeFea; Patrick Tremblay; M Torchia; Stephen J DeArmond; Stanley B Prusiner; Vishwanath R Lingappa
A transmembrane form of the prion protein in neurodegenerative disease.
Science (New York, N.Y.) 1998;279(5352):827-34.
1997: Ramanujan S Hegde; Vishwanath R Lingappa
Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum.
Cell 1997;91(5):575-82.
1997: Maryann Kivlen; C A Dorsey; Vishwanath R Lingappa; Ramanujan S Hegde
Asymmetric distribution of pause transfer sequences in apolipoprotein B-100.
Journal of lipid research 1997;38(6):1149-62.
1997: Jaisri R Lingappa; R L Hill; M L Wong; Ramanujan S Hegde
A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system.
The Journal of cell biology 1997;136(3):567-81.
1996: Ramanujan S Hegde; Vishwanath R Lingappa
Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol.
Cell 1996;85(2):217-28.
1995: Ramanujan S Hegde; J Zuo; Richard Voellmy; William J Welch
Short circuiting stress protein expression via a tyrosine kinase inhibitor, herbimycin A.
Journal of cellular physiology 1995;165(1):186-200.