Peter Hegemann

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Hideaki E Kato; Feng Zhang; Ofer Yizhar; Charu Ramakrishnan; Tomohiro Nishizawa; Kunio Hirata; Jumpei Ito; Yusuke Aita; Tomoya Tsukazaki; Shigehiko Hayashi; et al.
Crystal structure of the channelrhodopsin light-gated cation channel.
Sara Bruun; Hendrik Naumann; Uwe Kuhlmann; Claudia Schulz; Katja Stehfest; Peter Hegemann; Peter Hildebrandt
The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant.
Ofer Yizhar; Lief E Fenno; Matthias Prigge; Franziska Schneider; Thomas J Davidson; Daniel J O'Shea; Vikaas S Sohal; Inbal Goshen; Joel Finkelstein; Jeanne T Paz; et al.
Neocortical excitation/inhibition balance in information processing and social dysfunction.

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All Publications

2012: Hideaki E Kato; Feng Zhang; Ofer Yizhar; Charu Ramakrishnan; Tomohiro Nishizawa; Kunio Hirata; Jumpei Ito; Yusuke Aita; Tomoya Tsukazaki; Shigehiko Hayashi; et al.
Crystal structure of the channelrhodopsin light-gated cation channel.
Nature 2012;482(7385):369-74.
2011: Sara Bruun; Hendrik Naumann; Uwe Kuhlmann; Claudia Schulz; Katja Stehfest; Peter Hegemann; Peter Hildebrandt
The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant.
FEBS letters 2011;585(24):3998-4001.
2011: Ofer Yizhar; Lief E Fenno; Matthias Prigge; Franziska Schneider; Thomas J Davidson; Daniel J O'Shea; Vikaas S Sohal; Inbal Goshen; Joel Finkelstein; Jeanne T Paz; et al.
Neocortical excitation/inhibition balance in information processing and social dysfunction.
Nature 2011;477(7363):171-8.
2011: Dietrich Gradmann; André Berndt; Franziska Schneider; Peter Hegemann
Rectification of the channelrhodopsin early conductance.
Biophysical journal 2011;101(5):1057-68.
2011: André Berndt; Philipp Schoenenberger; Joanna Mattis; Kay M Tye; Karl Deisseroth; Peter Hegemann; Thomas G Oertner
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7595-600.
2011: Ofer Yizhar; Lief Fenno; Feng Zhang; Peter Hegemann; Karl Diesseroth
Microbial opsins: a family of single-component tools for optical control of neural activity.
Cold Spring Harbor protocols 2011;2011(3):top102.
2011: Manuela Stierl; Patrick Stumpf; Daniel Udwari; Ronnie Gueta; Rolf Hagedorn; Aba Losi; Wolfgang Gärtner; Linda Petereit; Marina Efetova; Martin Schwarzel; et al.
Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa.
The Journal of biological chemistry 2011;286(2):1181-8.
2011: Peter Hegemann; Andreas Möglich
Channelrhodopsin engineering and exploration of new optogenetic tools.
Nature methods 2011;8(1):39-42.
2010: A Tyagi; A Penzkofer; T Mathes; P Hegemann
Photophysical characterisation and photo-cycle dynamics of LOV1-His domain of phototropin from Chlamydomonas reinhardtii with roseoflavin monophosphate cofactor.
Journal of photochemistry and photobiology. B, Biology 2010;101(1):76-88.
2010: Katja Stehfest; Eglof Ritter; André Berndt; Franz Bartl; Peter Hegemann
The branched photocycle of the slow-cycling channelrhodopsin-2 mutant C128T.
Journal of molecular biology 2010;398(5):690-702.
2010: Matthias Prigge; Anton Rösler; Peter Hegemann
Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2.
Channels (Austin, Tex.) 2010;4(3):241-7.
2010: Katja Stehfest; Peter Hegemann
Evolution of the channelrhodopsin photocycle model.
Chemphyschem : a European journal of chemical physics and physical chemistry 2010;11(6):1120-6.
2010: André Berndt; Matthias Prigge; Dietrich Gradmann; Peter Hegemann
Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle.
Biophysical journal 2010;98(5):753-61.
2010: Lisa A Gunaydin; Ofer Yizhar; André Berndt; Vikaas S Sohal; Karl Deisseroth; Peter Hegemann
Ultrafast optogenetic control.
Nature neuroscience 2010;13(3):387-92.
2009: P Zirak; A Penzkofer; T Mathes; P Hegemann
Absorption and emission spectroscopic characterization of BLUF protein Slr1694 from Synechocystis sp. PCC6803 with roseoflavin cofactor.
Journal of photochemistry and photobiology. B, Biology 2009;97(2):61-70.
2009: Satoshi P Tsunoda; Peter Hegemann
Glu 87 of channelrhodopsin-1 causes pH-dependent color tuning and fast photocurrent inactivation.
Photochemistry and photobiology 2009;85(2):564-9.
2009: Boris Zorin; Yinghong Lu; Irina Sizova; Peter Hegemann
Nuclear gene targeting in Chlamydomonas as exemplified by disruption of the PHOT gene.
Gene 2009;432(1-2):91-6.
2009: Tilo Mathes; Christian Vogl; Jürgen Stolz; Peter Hegemann
In vivo generation of flavoproteins with modified cofactors.
Journal of molecular biology 2009;385(5):1511-8.
2009: André Berndt; Ofer Yizhar; Lisa A Gunaydin; Peter Hegemann; Karl Deisseroth
Bi-stable neural state switches.
Nature neuroscience 2009;12(2):229-34.
2008: Eglof Ritter; Katja Stehfest; Andre Berndt; Peter Hegemann; Franz J Bartl
Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy.
The Journal of biological chemistry 2008;283(50):35033-41.
2008: Rolf Hagedorn; Dietrich Gradmann; Peter Hegemann
Dynamics of voltage profile in enzymatic ion transporters, demonstrated in electrokinetics of proton pumping rhodopsin.
Biophysical journal 2008;95(11):5005-13.
2008: Oliver P Ernst; Pedro A Sánchez Murcia; Peter Daldrop; Satoshi P Tsunoda; Suneel Kateriya; Peter Hegemann
Photoactivation of channelrhodopsin.
The Journal of biological chemistry 2008;283(3):1637-43.
2008: Peter Hegemann
Algal sensory photoreceptors.
Annual review of plant biology 2008;59():167-89.
2007: Gilbert Nöll; Günter Hauska; Peter Hegemann; Karin Lanzl; Tanja Nöll; Madlene von Sanden-Flohe; Bernhard Dick
Redox properties of LOV domains: chemical versus photochemical reduction, and influence on the photocycle.
Chembiochem : a European journal of chemical biology 2007;8(18):2256-64.
2007: S-H Song; B Dick; A Penzkofer; P Hegemann
Photo-reduction of flavin mononucleotide to semiquinone form in LOV domain mutants of blue-light receptor phot from Chlamydomonas reinhardtii.
Journal of photochemistry and photobiology. B, Biology 2007;87(1):37-48.
2007: P Zirak; A Penzkofer; C Lehmpfuhl; T Mathes; P Hegemann
Absorption and emission spectroscopic characterization of blue-light receptor Slr1694 from Synechocystis sp. PCC6803.
Journal of photochemistry and photobiology. B, Biology 2007;86(1):22-34.
2007: Saskia Schröder-Lang; Martin Schwärzel; Reinhard Seifert; Timo Strünker; Suneel Kateriya; Jens Looser; Masakatsu Watanabe; U Benjamin Kaupp; Peter Hegemann; Georg Nagel
Fast manipulation of cellular cAMP level by light in vivo.
Nature methods 2007;4(1):39-42.
2006: Satoshi P Tsunoda; David Ewers; Sabrina Gazzarrini; Anna Moroni; Dietrich Gradmann; Peter Hegemann
H+ -pumping rhodopsin from the marine alga Acetabularia.
Biophysical journal 2006;91(4):1471-9.
2006: Tilman Kottke; Peter Hegemann; Bernhard Dick; Joachim Heberle
The photochemistry of the light-, oxygen-, and voltage-sensitive domains in the algal blue light receptor phot.
Biopolymers 2006;82(4):373-8.
2006: P Zirak; A Penzkofer; T Schiereis; P Hegemann; A Jung; I Schlichting
Photodynamics of the small BLUF protein BlrB from Rhodobacter sphaeroides.
Journal of photochemistry and photobiology. B, Biology 2006;83(3):180-94.
2005: Peter Hegemann; Sabine Ehlenbeck; Dietrich Gradmann
Multiple photocycles of channelrhodopsin.
Biophysical journal 2005;89(6):3911-8.
2005: S-H Song; B Dick; P Zirak; A Penzkofer; T Schiereis; P Hegemann
Absorption and emission spectroscopic characterisation of combined wildtype LOV1-LOV2 domain of phot from Chlamydomonas reinhardtii.
Journal of photochemistry and photobiology. B, Biology 2005;81(1):55-65.
2005: G Nagel; T Szellas; S Kateriya; N Adeishvili; P Hegemann; E Bamberg
Channelrhodopsins: directly light-gated cation channels.
Biochemical Society transactions 2005;33(Pt 4):863-6.
2005: Boris Zorin; Peter Hegemann; Irina Sizova
Nuclear-gene targeting by using single-stranded DNA avoids illegitimate DNA integration in Chlamydomonas reinhardtii.
Eukaryotic cell 2005;4(7):1264-72.
2005: Huimin Guo; Tilman Kottke; Peter Hegemann; Bernhard Dick
The phot LOV2 domain and its interaction with LOV1.
Biophysical journal 2005;89(1):402-12.
2005: Markus Fuhrmann; Wolfgang Oertel; Peter Berthold; Peter Hegemann
Removal of mismatched bases from synthetic genes by enzymatic mismatch cleavage.
Nucleic acids research 2005;33(6):e58.
2005: V I Shalguev; O K Kaboev; I A Sizova; P Hegemann; V A Lantsov
[Identification of Rad51 protein from Chlamydomonas reinhardtii: recombinational characteristics].
Molekuliarnaia biologiia 2005;39(1):112-9.
2004: Markus Fuhrmann; Amparo Hausherr; Lars Ferbitz; Thomas Schödl; Markus Heitzer; Peter Hegemann
Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene.
Plant molecular biology 2004;55(6):869-81.
2004: T Bednarz; A Losi; W Gartner; P Hegemann; J Heberle
Functional variations among LOV domains as revealed by FT-IR difference spectroscopy.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004;3(6):575-9.
2004: Suneel Kateriya; Georg Nagel; Ernst Bamberg; Peter Hegemann
"Vision" in single-celled algae.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2004;19():133-7.
2004: Aba Losi; Tilman Kottke; Peter Hegemann
Recording of blue light-induced energy and volume changes within the wild-type and mutated phot-LOV1 domain from Chlamydomonas reinhardtii.
Biophysical journal 2004;86(2):1051-60.
2003: Georg Nagel; Tanjef Szellas; Wolfram Huhn; Suneel Kateriya; Nona Adeishvili; Peter Berthold; Doris Ollig; Peter Hegemann; Ernst Bamberg
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):13940-5.
2003: Tilman Kottke; Bernhard Dick; Roman Fedorov; Ilme Schlichting; Rainer Deutzmann; Peter Hegemann
Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain.
Biochemistry 2003;42(33):9854-62.
2003: Roman Fedorov; Ilme Schlichting; Elisabeth Hartmann; Tatjana Domratcheva; Markus Fuhrmann; Peter Hegemann
Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii.
Biophysical journal 2003;84(4):2474-82.
2003: Tilman Kottke; Joachim Heberle; Dominic Hehn; Bernhard Dick; Peter Hegemann
Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii.
Biophysical journal 2003;84(2 Pt 1):1192-201.
2003: K Ataka; P Hegemann; J Heberle
Vibrational spectroscopy of an algal Phot-LOV1 domain probes the molecular changes associated with blue-light reception.
Biophysical journal 2003;84(1):466-74.
2002: D Gradmann; S Ehlenbeck; P Hegemann
Modeling light-induced currents in the eye of Chlamydomonas reinhardtii.
The Journal of membrane biology 2002;189(2):93-104.
2002: Georg Nagel; Doris Ollig; Markus Fuhrmann; Suneel Kateriya; Anna Maria Musti; Ernst Bamberg; Peter Hegemann
Channelrhodopsin-1: a light-gated proton channel in green algae.
Science (New York, N.Y.) 2002;296(5577):2395-8.
2002: W Holzer; A Penzkofer; M Fuhrmann; P Hegemann
Spectroscopic characterization of flavin mononucleotide bound to the LOV1 domain of Phot1 from Chlamydomonas reinhardtii.
Photochemistry and photobiology 2002;75(5):479-87.
2002: Sabine Ehlenbeck; Dietrich Gradmann; Franz-Josef Braun; Peter Hegemann
Evidence for a light-induced H(+) conductance in the eye of the green alga Chlamydomonas reinhardtii.
Biophysical journal 2002;82(2):740-51.
2002: I A Sizova; P Hegemann; M Furmann; V N Danilenko
[Streptomyces rimosus aminoglycoside-3'-phosphotransferase VIII: comparisons with aminoglycoside-3'-phosphotransferases of aminoglycoside-producing strains with eukaryotic protein kinases].
Molekuliarnaia biologiia 2002;36(1):27-36.
2001: M Fuhrmann; A Stahlberg; E Govorunova; S Rank; P Hegemann
The abundant retinal protein of the Chlamydomonas eye is not the photoreceptor for phototaxis and photophobic responses.
Journal of cell science 2001;114(Pt 21):3857-63.
2001: I Sizova; M Fuhrmann; P Hegemann
A Streptomyces rimosus aphVIII gene coding for a new type phosphotransferase provides stable antibiotic resistance to Chlamydomonas reinhardtii.
Gene 2001;277(1-2):221-9.
2000: W Deininger; M Fuhrmann; P Hegemann
Opsin evolution: out of wild green yonder?
Trends in genetics : TIG 2000;16(4):158-9.
1999: M Fuhrmann; W Oertel; P Hegemann
A synthetic gene coding for the green fluorescent protein (GFP) is a versatile reporter in Chlamydomonas reinhardtii.
The Plant journal : for cell and molecular biology 1999;19(3):353-61.
1999: E Ebnet; M Fischer; W Deininger; P Hegemann
Volvoxrhodopsin, a light-regulated sensory photoreceptor of the spheroidal green alga Volvox carteri.
The Plant cell 1999;11(8):1473-84.
1999: F J Braun; P Hegemann
Direct measurement of cytosolic calcium and pH in living Chlamydomonas reinhardtii cells.
European journal of cell biology 1999;78(3):199-208.
1999: F J Braun; P Hegemann
Two light-activated conductances in the eye of the green alga Volvox carteri.
Biophysical journal 1999;76(3):1668-78.
1996: C Nonnengässer; E M Holland; H Harz; P Hegemann
The nature of rhodopsin-triggered photocurrents in Chlamydomonas. II. Influence of monovalent ions.
Biophysical journal 1996;70(2):932-8.
1996: E M Holland; F J Braun; C Nonnengässer; H Harz; P Hegemann
The nature of rhodopsin-triggered photocurrents in Chlamydomonas. I. Kinetics and influence of divalent ions.
Biophysical journal 1996;70(2):924-31.
1995: W Deininger; P Kröger; U Hegemann; F Lottspeich; P Hegemann
Chlamyrhodopsin represents a new type of sensory photoreceptor.
The EMBO journal 1995;14(23):5849-58.
1994: P Kröger; P Hegemann
Photophobic responses and phototaxis in Chlamydomonas are triggered by a single rhodopsin photoreceptor.
FEBS letters 1994;341(1):5-9.
1991: P Hegemann; W Gärtner; R Uhl
All-trans retinal constitutes the functional chromophore in Chlamydomonas rhodopsin.
Biophysical journal 1991;60(6):1477-89.
1991: M Beckmann; P Hegemann
In vitro identification of rhodopsin in the green alga Chlamydomonas.
Biochemistry 1991;30(15):3692-7.
1990: R Uhl; P Hegemann
Probing visual transduction in a plant cell: Optical recording of rhodopsin-induced structural changes from Chlamydomonas reinhardtii.
Biophysical journal 1990;58(5):1295-302.
1990: P Hegemann; K Neumeier; U Hegemann; E Kuehnle
The role of calcium in Chlamydomonas photomovement responses as analysed by calcium channel inhibitors.
Photochemistry and photobiology 1990;52(3):575-83.
1988: P Hegemann; U Hegemann; K W Foster
Reversible bleaching of Chlamydomonas reinhardtii rhodopsin in vivo.
Photochemistry and photobiology 1988;48(1):123-8.
1987: P Hegemann; A Blanck; H Vogelsang-Wenke; F Lottspeich; D Oesterhelt
The halo-opsin gene. I. Identification and isolation.
The EMBO journal 1987;6(1):259-64.
1985: D Oesterhelt; P Hegemann; J Tittor
The photocycle of the chloride pump halorhodopsin. II: Quantum yields and a kinetic model.
The EMBO journal 1985;4(9):2351-6.
1985: P Hegemann; D Oesterbelt; M Steiner
The photocycle of the chloride pump halorhodopsin. I: Azide-catalyzed deprotonation of the chromophore is a side reaction of photocycle intermediates inactivating the pump.
The EMBO journal 1985;4(9):2347-50.
1982: P Hegemann; M Steiner; D Oesterhelt
Isolation and characterization of the retinal-binding component of halorhodopsin.
The EMBO journal 1982;1(10):1177-83.