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John Ashby

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William Owens; L Earl Gray; Errol Zeiger; Michael Walker; Kanji Yamasaki; John Ashby; Elard Jacob
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies.
William Owens; Errol Zeiger; Michael Walker; John Ashby; Lesley Onyon; L Earl Gray
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses. Phase 1: use of a potent agonist and a potent antagonist to test the standardized protocol.
Ruth Stuckey; Tom Aldridge; Fei Ling Lim; David Moore; Helen Tinwell; Nicola Doherty; Reginald Davies; Andrew G Smith; Ian Kimber; John Ashby; George Orphanides; Jonathan G Moggs
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.

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2007: William Owens; L Earl Gray; Errol Zeiger; Michael Walker; Kanji Yamasaki; John Ashby; Elard Jacob
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies.
Environmental health perspectives 2007;115(5):671-8.
2006: William Owens; Errol Zeiger; Michael Walker; John Ashby; Lesley Onyon; L Earl Gray
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses. Phase 1: use of a potent agonist and a potent antagonist to test the standardized protocol.
Environmental health perspectives 2006;114(8):1259-65.
2006: Ruth Stuckey; Tom Aldridge; Fei Ling Lim; David Moore; Helen Tinwell; Nicola Doherty; Reginald Davies; Andrew G Smith; Ian Kimber; John Ashby; George Orphanides; Jonathan G Moggs
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
Molecular and cellular endocrinology 2006;253(1-2):22-9.
2005: John Ashby; Angela Burns; Jenny Odum; Paul Lefevre
The reported in vitro anti-estrogen pentachloronitrobenzene enhances the estrogenic activity of estradiol in vivo in the rat.
Environmental toxicology and pharmacology 2005;20(1):199-208.
2004: John Ashby; Jenny Odum
Gene expression changes in the immature rat uterus: effects of uterotrophic and sub-uterotrophic doses of bisphenol A.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):458-67.
2004: Jonathan G Moggs; Helen Tinwell; Tracey Spurway; Hur-Song Chang; Ian Pate; Fei Ling Lim; David Moore; Anthony Soames; Ruth Stuckey; Richard Currie; Tong Zhu; Ian Kimber; John Ashby; George Orphanides
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.
Environmental health perspectives 2004;112(16):1589-606.
2004: Jonathan G Moggs; John Ashby; Helen Tinwell; Fei Ling Lim; David Moore; Ian Kimber; George Orphanides
The need to decide if all estrogens are intrinsically similar.
Environmental health perspectives 2004;112(11):1137-42.
2004: John Ashby; Helen Tinwell; Jenny Odum; Paul A Lefevre
Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.
Environmental health perspectives 2004;112(8):847-53.
2004: Helen Tinwell; John Ashby
Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens.
Environmental health perspectives 2004;112(5):575-82.
2004: John Ashby; Paul A Lefevre; Helen Tinwell; Jenny Odum; William Owens
Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay.
Regulatory toxicology and pharmacology : RTP 2004;39(2):229-38.
2003: John Ashby
Problems associated with the recognition and confirmation of low-dose endocrine toxicities.
Nonlinearity in biology, toxicology, medicine 2003;1(4):439-53.
2003: John Ashby; William Owens; Jenny Odum; Helen Tinwell
The intact immature rodent uterotrophic bioassay: possible effects on assay sensitivity of vomeronasal signals from male rodents and strain differences.
Environmental health perspectives 2003;111(12):1568-70.
2003: William Owens; John Ashby; Jenny Odum; Lesley Onyon
The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses.
Environmental health perspectives 2003;111(12):1559-67.
2003: Jun Kanno; Lesley Onyon; Shyamal Peddada; John Ashby; Elard Jacob; William Owens
The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies.
Environmental health perspectives 2003;111(12):1550-8.
2003: Jun Kanno; Lesley Onyon; Shyamal Peddada; John Ashby; Elard Jacob; William Owens
The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies.
Environmental health perspectives 2003;111(12):1530-49.
2003: John Ashby; Ian Pate; Helen Tinwell
Reported seasonal dependence of herbicide developmental toxicity in mice.
Environmental health perspectives 2003;111(9):A450-1.
2003: John Ashby; Helen Tinwell; Paul A Lefevre; Ronald L Joiner; J Haseman
The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):129-38.
2003: John Ashby
The leading role and responsibility of the international scientific community in test development.
Toxicology letters 2003;140-141():37-42.
2003: Richard W Lewis; Nigel Brooks; Gillian M Milburn; Anthony Soames; Susan Stone; Michael Hall; John Ashby
The effects of the phytoestrogen genistein on the postnatal development of the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(1):74-83.
2002: John Ashby
Scientific issues associated with the validation of in vitro and in vivo methods for assessing endocrine disrupting chemicals.
Toxicology 2002;181-182():389-97.
2002: Helen Tinwell; J Haseman; Paul A Lefevre; NT Wallis; John Ashby
Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):339-48.
2002: Jenny Odum; Paul A Lefevre; Helen Tinwell; John P Van Miller; Ronald L Joiner; Robert Chapin; NT Wallis; John Ashby
Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):147-63.
2002: John Ashby; Helen Tinwell; J Stevens; T Pastoor; C B Breckenridge
The effects of atrazine on the sexual maturation of female rats.
Regulatory toxicology and pharmacology : RTP 2002;35(3):468-73.
2002: John Ashby; William Owens; R Deghenghi; Jenny Odum
Concept evaluation: an assay for receptor-mediated and biochemical antiestrogens using pubertal rats.
Regulatory toxicology and pharmacology : RTP 2002;35(3):393-7.
2002: Helen Tinwell; Paul A Lefevre; Graeme J Moffat; A Burns; Jenny Odum; T D Spurway; George Orphanides; John Ashby
Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.
Environmental health perspectives 2002;110(5):533-6.
2002: John Ashby; William Owens; Paul A Lefevre
Concept evaluation: androgen-stimulated immature intact male rats as an assay for antiandrogens.
Regulatory toxicology and pharmacology : RTP 2002;35(2 Pt 1):280-5.
2002: Clifford R Elcombe; Jenny Odum; John R Foster; Susan Stone; Susan Hasmall; Anthony Soames; Ian Kimber; John Ashby
Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.
Environmental health perspectives 2002;110(4):363-75.
2002: Jenny Odum; John Ashby
Detection of aromatase inhibitors in vitro using rat ovary microsomes.
Toxicology letters 2002;129(1-2):119-22.
2001: John Ashby; Helen Tinwell; J Plautz; K Twomey; Paul A Lefevre
Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S.
Regulatory toxicology and pharmacology : RTP 2001;34(3):287-91.
2001: John Ashby
Mouse uterine carcinogenicity of genistein: the currently most secure example of non-genotoxic rodent carcinogenicity?
Mutation research 2001;483(1-2):107-8.
2001: John Ashby; Helen Tinwell; Jenny Odum
DNA adducts, estrogenicity and rodent diets.
Mutation research 2001;483(1-2):105-6.
2001: John Ashby; Paul A Lefevre; R Deghenghi; NT Wallis
Replacement of surgical castration by GnRH-inhibition or Leydig cell ablation in the male rat Hershberger antiandrogen assay.
Regulatory toxicology and pharmacology : RTP 2001;34(2):188-203.
2001: G J Moffat; A Burns; John P Van Miller; Ronald L Joiner; John Ashby
Glucuronidation of nonylphenol and octylphenol eliminates their ability to activate transcription via the estrogen receptor.
Regulatory toxicology and pharmacology : RTP 2001;34(2):182-7.
2001: John Ashby; Paul A Lefevre
Replacement of surgical castration by GnRH inhibition for rat prostate androgen receptor preparations.
Journal of applied toxicology : JAT 2001;21(5):353-4.
2001: Jun Kanno; Lesley Onyon; J Haseman; P Fenner-Crisp; John Ashby; William Owens
The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1.
Environmental health perspectives 2001;109(8):785-94.
2001: John Ashby; Helen Tinwell
Continuing ability of the rodent bone marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals.
Mutation research 2001;478(1-2):211-3.
2001: E Vicky Warbrick; Rebecca J Dearman; John Ashby; P Schmezer; Ian Kimber
Preliminary assessment of the skin sensitizing activity of selected rodent carcinogens using the local lymph node assay.
Toxicology 2001;163(1):63-9.
2001: Jenny Odum; Helen Tinwell; K Jones; John P Van Miller; Ronald L Joiner; G Tobin; H Kawasaki; R Deghenghi; John Ashby
Effect of rodent diets on the sexual development of the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2001;61(1):115-27.
2001: Robert Elsby; James L Maggs; John Ashby; B Kevin Park
Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans.
The Journal of pharmacology and experimental therapeutics 2001;297(1):103-13.
2001: John Ashby
Testing for endocrine disruption post-EDSTAC: extrapolation of low dose rodent effects to humans.
Toxicology letters 2001;120(1-3):233-42.
2001: Helen Tinwell; M H Brinkworth; John Ashby
Further evidence for the rodent bone marrow micronucleus assay acting as a sensitive predictor of the possible germ cell mutagenicity of chemicals.
Mutation research 2001;473(2):259-61.
2001: Robert Elsby; James L Maggs; John Ashby; D Paton; John P Sumpter; B Kevin Park
Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay.
The Journal of pharmacology and experimental therapeutics 2001;296(2):329-37.
2001: Jenny Odum; Helen Tinwell; John P Van Miller; Ronald L Joiner; John Ashby
The uterotrophic activity of nonylphenol in the rat is not mediated by aromatase enzyme induction.
Toxicology letters 2001;118(3):165-9.
2000: Robert Elsby; John Ashby; John P Sumpter; AN Brooks; William D Pennie; James L Maggs; P A Lefevre; Jenny Odum; N Beresford; D Paton; B Kevin Park
Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.
Biochemical pharmacology 2000;60(10):1519-30.
2000: John Ashby; Helen Tinwell; Jenny Odum; Ian Kimber; AN Brooks; Ian Pate; C C Boyle
Diet and the aetiology of temporal advances in human and rodent sexual development.
Journal of applied toxicology : JAT 2000;20(5):343-7.
2000: Helen Tinwell; Ronald L Joiner; Ian Pate; Anthony Soames; J Foster; John Ashby
Uterotrophic activity of bisphenol A in the immature mouse.
Regulatory toxicology and pharmacology : RTP 2000;32(1):118-26.
2000: Jenny Odum; John Ashby
Neonatal exposure of male rats to nonylphenol has no effect on the reproductive tract.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(2):400-4.
2000: Helen Tinwell; Anthony Soames; John R Foster; John Ashby
Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays.
Environmental health perspectives 2000;108(7):631-4.
2000: John Ashby; Jenny Odum; D Paton; Paul A Lefevre; NA Beresford; John P Sumpter
Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3, 4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays.
Toxicology letters 2000;115(3):231-8.
2000: John Ashby; P A Lefevre
The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators.
Journal of applied toxicology : JAT 2000;20(1):35-47.
1999: I Slater; Jenny Odum; John Ashby
Resveratrol and red wine consumption.
Human & experimental toxicology 1999;18(10):625-6.
1999: John Ashby; Helen Tinwell; J Haseman
Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero.
Regulatory toxicology and pharmacology : RTP 1999;30(2 Pt 1):156-66.
1999: John Ashby; Helen Tinwell; Anthony Soames; J Foster
Induction of hyperplasia and increased DNA content in the uterus of immature rats exposed to coumestrol.
Environmental health perspectives 1999;107(10):819-22.
1999: Jenny Odum; IT Pyrah; Anthony Soames; John R Foster; John P Van Miller; Ronald L Joiner; John Ashby
Effects of p-nonylphenol (NP) and diethylstilboestrol (DES) on the Alderley Park (Alpk) rat: comparison of mammary gland and uterus sensitivity following oral gavage or implanted mini-pumps.
Journal of applied toxicology : JAT 1999;19(5):367-78.
1999: Jenny Odum; IT Pyrah; John R Foster; John P Van Miller; Ronald L Joiner; John Ashby
Comparative activities of p-nonylphenol and diethylstilbestrol in noble rat mammary gland and uterotrophic assays.
Regulatory toxicology and pharmacology : RTP 1999;29(2 Pt 1):184-95.
1999: K Fletcher; Anthony Soames; Helen Tinwell; Paul A Lefevre; John Ashby
Hepatic gene mutations induced in Big Blue rats by both the potent rat liver azo-carcinogen 6BT and its reported noncarcinogenic analogue 5BT.
Environmental and molecular mutagenesis 1999;34(2-3):148-53.
1999: John Ashby; Helen Tinwell; William D Pennie; AN Brooks; Paul A Lefevre; NA Beresford; John P Sumpter
Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects.
Journal of applied toxicology : JAT 1999;19(1):39-45.
1998: Edwin J Routledge; J Parker; Jenny Odum; John Ashby; John P Sumpter
Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic.
Toxicology and applied pharmacology 1998;153(1):12-9.
1998: John Ashby; Helen Tinwell
Oestrogenic activity of burgen bread to female rats.
Human & experimental toxicology 1998;17(11):598-9.
1998: John Ashby; Helen Tinwell
Uterotrophic activity of bisphenol A in the immature rat.
Environmental health perspectives 1998;106(11):719-20.
1998: Jenny Odum; S Tittensor; John Ashby
Limitations of the mcf-7 cell proliferation assay for detecting xenobiotic oestrogens.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(3):273-8.
1998: K Fletcher; Helen Tinwell; John Ashby
Mutagenicity of the human bladder carcinogen 4-aminobiphenyl to the bladder of MutaMouse transgenic mice.
Mutation research 1998;400(1-2):245-50.
1998: C V Williams; K Fletcher; Helen Tinwell; John Ashby
Mutagenicity of ethyl carbamate to lacZ- transgenic mice.
Mutagenesis 1998;13(2):133-7.
1998: Helen Tinwell; Paul A Lefevre; John Ashby
Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of MutaMouse mice.
Environmental and molecular mutagenesis 1998;32(2):163-72.
1997: John Ashby; K Fletcher; C Williams; Jenny Odum; Helen Tinwell
Lack of activity of estradiol in rodent bone marrow micronucleus assays.
Mutation research 1997;395(1):83-8.
1997: John Ashby; Paul A Lefevre
The weanling male rat as an assay for endocrine disruption: preliminary observations.
Regulatory toxicology and pharmacology : RTP 1997;26(3):330-7.
1997: John Ashby; Helen Tinwell; Paul A Lefevre; J Williams; L Kier; I D Adler; M J Clapp
Evaluation of the mutagenicity of acetochlor to male rat germ cells.
Mutation research 1997;393(3):263-81.
1997: John Ashby; Helen Tinwell; Paul A Lefevre; Jenny Odum; D Paton; S W Millward; S Tittensor; AN Brooks
Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):102-18.
1997: John Ashby; Paul A Lefevre; Jenny Odum; Helen Tinwell; S J Kennedy; NA Beresford; John P Sumpter
Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):96-101.
1997: John Ashby; Jenny Odum; Helen Tinwell; Paul A Lefevre
Assessing the risks of adverse endocrine-mediated effects: where to from here?
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):80-93.
1997: John Ashby
A hierarchical approach to the evaluation of chemicals for estrogenic and other endocrine-disrupting properties.
Environmental toxicology and pharmacology 1997;3(2):87-90.
1997: John Ashby; Jenny Odum; John R Foster
Activity of raloxifene in immature and ovariectomized rat uterotrophic assays.
Regulatory toxicology and pharmacology : RTP 1997;25(3):226-31.
1997: J E Yendle; Helen Tinwell; B M Elliott; John Ashby
The genetic toxicity of time: importance of DNA-unwinding time to the outcome of single-cell gel electrophoresis assays.
Mutation research 1997;375(2):125-36.
1997: Jenny Odum; Paul A Lefevre; S Tittensor; D Paton; Edwin J Routledge; NA Beresford; John P Sumpter; John Ashby
The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay.
Regulatory toxicology and pharmacology : RTP 1997;25(2):176-88.
1997: John Ashby
Identifying potential human carcinogens--the role of genetically altered rodents.
Toxicologic pathology 1997;25(2):241-3.
1997: Helen Tinwell; Paul A Lefevre; C V Williams; John Ashby
The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay.
Mutation research 1997;388(2-3):179-85.
1997: John Ashby; N J Gorelick; M D Shelby
Mutation assays in male germ cells from transgenic mice: overview of study and conclusions.
Mutation research 1997;388(2-3):111-22.
1997: John Ashby; Paul A Lefevre; Jenny Odum; Catherine A Harris; Edwin J Routledge; John P Sumpter
Synergy between synthetic oestrogens?
Nature 1997;385(6616):494.
1997: Paul A Lefevre; Helen Tinwell; John Ashby
Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic (lacI) rats: consideration of a reduced mutation assay protocol.
Mutagenesis 1997;12(1):45-7.
1996: John Ashby; Paul A Lefevre; B M Elliott; M J Clapp
Methyl methanesulphonate (MMS) as a resource conserving and reliable positive control agent for male rat and male mouse dominant lethal assays.
Mutagenesis 1996;11(6):611-3.
1996: Helen Tinwell; John Ashby; C V Williams
Presence of alpha-lactose in some batches of proprietary LB broth: relevance to the MutaMouse lacZ gene mutation assay.
Mutation research 1996;358(1):123-4.
1996: John Ashby
Prediction of rodent carcinogenicity for 30 chemicals.
Environmental health perspectives 1996;104 Suppl 5():1101-4.
1996: Helen Tinwell; J Yendle; John Ashby
Mutagenicity to the mouse bone marrow by the mouse germ cell mutagen N-propyl-N-nitrosourea.
Mutation research 1996;370(3-4):141-3.
1996: E Zeiger; John Ashby; G Bakale; K Enslein; G Klopman; H S Rosenkranz
Prediction of Salmonella mutagenicity.
Mutagenesis 1996;11(5):471-84.
1996: John Ashby; L Kier; A G Wilson; T Green; Paul A Lefevre; Helen Tinwell; G A Willis; W F Heydens; M J Clapp
Evaluation of the potential carcinogenicity and genetic toxicity to humans of the herbicide acetochlor.
Human & experimental toxicology 1996;15(9):702-35.
1996: Helen Tinwell; M J Clapp; John Ashby
Fate of unfertilized ova in male rodent dominant lethal assays: extension of the studies by Kratochvilova.
Mutation research 1996;368(3-4):309-17.
1996: John Ashby
Alternatives to the 2-species bioassay for the identification of potential human carcinogens.
Human & experimental toxicology 1996;15(3):183-202.
1996: John Ashby
Assessing chemicals for estrogenic/hormone-disrupting properties: lessons from carcinogenicity assessment.
Environmental health perspectives 1996;104(2):132-4.
1996: John Ashby
Cost-effective methods for identifying carcinogens.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(2-3):167.
1996: John Ashby
Series: current issues in mutagenesis and carcinogenesis, No. 66. Lijinsky's observation that the spontaneous tumour incidence in F334 rats is unaffected by prior damage to DNA.
Mutation research 1996;349(2):289-90.
1996: Helen Tinwell; D Paton; J B Guttenplan; John Ashby
Unexpected genetic toxicity to rodents of the N',N'-dimethyl analogues of MNU and ENU.
Environmental and molecular mutagenesis 1996;27(3):202-10.
1995: John Ashby
Rodent mutation assay data presentation and statistical assessment.
Mutation research 1995;331(2):233-5.
1995: Helen Tinwell; U Liegibel; Ottheinz Krebs; Peter Schmezer; Jack Favor; John Ashby
Comparison of lacI and lacZ transgenic mouse mutation assays: an EU-sponsored interlaboratory study.
Mutation research 1995;335(2):185-90.
1995: John Ashby; J Hilton; Rebecca J Dearman; Ian Kimber
Streptozotocin: inherent but not expressed skin sensitizing activity.
Contact dermatitis 1995;33(3):165-7.
1995: John Ashby; D Paton
Chemicals for evaluating the sensitivity and specificity of reduced/transgenic rodent cancer bioassay protocols.
Mutation research 1995;331(1):27-38.
1995: John Ashby; M J Clapp
The rodent dominant lethal assay: a proposed format for data presentation that alerts to pseudo-dominant lethal effects.
Mutation research 1995;330(1-2):209-18.
1995: John Ashby
Druckrey's definition of 'genotoxic'.
Mutation research 1995;329(2):225.
1995: V Morrison; Helen Tinwell; John Ashby
Consideration of the liver of embryonic lacZ transgenic mice as an analogue of the mouse coat colour spot test: preliminary data and technical problems.
Mutation research 1995;329(2):107-12.
1995: NH James; John Ashby; Ruth A Roberts
Enhanced hepatocyte colony growth in soft agar after in vivo treatment with a genotoxic carcinogen: a potential assay for hepatocarcinogens?
Cancer letters 1995;93(1):121-8.
1995: John Ashby; H Tinwell
Current issues in mutagenesis and carcinogenesis, No. 55. Activity of etoposide in the mouse bone marrow micronucleus test: independence of route of exposure.
Mutation research 1995;328(2):243-44.
1995: John Ashby
Series: current issues in mutagenesis and carcinogenesis, No. 54. Rodent germ cell mutagens and their activity in the rodent bone marrow micronucleus assay.
Mutation research 1995;328(2):239-41.
1995: John Ashby; Helen Tinwell
A sequential approach to testing with the rodent bone marrow micronucleus assay--obviation of the need for statistical analyses of data.
Mutation research 1995;327(1-2):49-55.
1994: John Ashby; A Brady; Clifford R Elcombe; B M Elliott; J Ishmael; Jenny Odum; JD Tugwood; S Kettle; I F Purchase
Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis.
Human & experimental toxicology 1994;13 Suppl 2():S1-117.
1994: Paul A Lefevre; Helen Tinwell; Sheila M Galloway; R Hill; JM Mackay; Clifford R Elcombe; J Foster; V Randall; R D Callander; John Ashby
Evaluation of the genetic toxicity of the peroxisome proliferator and carcinogen methyl clofenapate, including assays using Muta Mouse and Big Blue transgenic mice.
Human & experimental toxicology 1994;13(11):764-75.
1994: John Ashby
Series: current issues in mutagenesis and carcinogenesis, No. 51. Dose-level selection for in vivo genetic toxicity assays.
Mutation research 1994;311(1):165.
1994: John Ashby; Jay Short; Nigel Jones; Paul A Lefevre; G S Provost; B J Rogers; E A Martin; James M Parry; K Burnette; Barry W Glickman
Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction.
Carcinogenesis 1994;15(10):2291-6.
1994: Helen Tinwell; John Ashby
Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment.
Environmental health perspectives 1994;102(9):758-62.
1994: Helen Tinwell; John Ashby
Genetic toxicity and potential carcinogenicity of taxol.
Carcinogenesis 1994;15(8):1499-501.
1994: John Ashby
The genotoxicity of 1,4-dioxane.
Mutation research 1994;322(2):141-2.
1994: John Ashby
Regulatory requirement for three dose levels and proof of tissue localisation in rodent genetic toxicity assays--a call for supporting data.
Mutation research 1994;308(2):243-4.
1994: John Ashby; Helen Tinwell; R Weaver; PM Cullis
Similar activity of chlorambucil and its spermidine conjugate in the mouse bone marrow micronucleus assay.
Mutagenesis 1994;9(4):391-2.
1994: John Ashby
Propositions in genetic toxicology and their erasure.
Mutation research 1994;308(1):113-4.
1994: John Ashby
Statistical versus biological significance of genetic toxicity data.
Mutation research 1994;308(1):109-10.
1994: Helen Tinwell; Paul A Lefevre; John Ashby
Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.
Mutation research 1994;307(2):501-8.
1994: John Ashby
Benzyl acetate: from mutagenic carcinogen to non-mutagenic non-carcinogenic in 7 years?
Mutation research 1994;306(1):107-9.
1994: John Ashby
International Commission for Protection Against Environmental Mutagens and Carcinogens. Two million rodent carcinogens? The role of SAR and QSAR in their detection.
Mutation research 1994;305(1):3-12.
1994: John Ashby; R W Tennant
Prediction of rodent carcinogenicity for 44 chemicals: results.
Mutagenesis 1994;9(1):7-15.
1994: John Ashby; Helen Tinwell; P Glover; P Poorman-Allen; R Krehl; R D Callander; D Clive
Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.
Environmental and molecular mutagenesis 1994;24(1):51-60.
1993: C E Doyle; J M Mackay; John Ashby
Failure of N-acetylcysteine to protect the mouse bone marrow against the clastogenicity of 7,12-dimethylbenzanthracene.
Mutagenesis 1993;8(6):583-4.
1993: John Ashby; I F Purchase
Will all chemicals be carcinogenic to rodents when adequately evaluated?
Mutagenesis 1993;8(6):489-93.
1993: John Ashby; W Anwar; W W Au; A Massoud; J M Gentile
Genetic toxicology in developing countries: comments and recommendations.
Environmental health perspectives 1993;101 Suppl 3():335-8.
1993: John Ashby; D Brusick; B C Myhr; Nigel Jones; J M Parry; S Nesnow; D Paton; Helen Tinwell; H S Rosenkranz; S Curti
Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z- mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assays.
Mutation research 1993;292(1):25-40.
1993: John Ashby
Treosulphan, myleran and butadiene: similarities and differences.
Mutation research 1993;300(2):77-8.
1993: John Ashby; J Hilton; R J Dearman; R D Callander; Ian Kimber
Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity.
Environmental health perspectives 1993;101(1):62-7.
1993: John Ashby; D Paton
The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures.
Mutation research 1993;286(1):3-74.
1993: John Ashby; E W Vogel; Helen Tinwell; R D Callander; D E Shuker
Mutagenicity to Salmonella, Drosophila and the mouse bone marrow of the human antineoplastic agent fotemustine: prediction of carcinogenic potency.
Mutation research 1993;286(1):101-9.
1993: John Ashby
Precedents or possibilities: which should guide the harmonization of mutagenicity test protocols and carcinogen prediction strategies?
Mutation research 1993;298(4):291-5.
1992: John Ashby; I F Purchase
Nongenotoxic carcinogens: an extension of the perspective provided by Perera.
Environmental health perspectives 1992;98():223-6.
1992: U Liegibel; Helen Tinwell; R D Callander; Peter Schmezer; John Ashby
Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin streptozotocin.
Mutagenesis 1992;7(6):471-4.
1992: John Ashby
Consideration of CASE predictions of genotoxic carcinogenesis for omeprazole, methapyrilene and azathioprine.
Mutation research 1992;272(1):1-7.
1992: P Lefevre; John Ashby
Mitogenic activity of quinoline to the rat, mouse, and guinea pig liver: empirical correlations with hepatic carcinogenicity.
Environmental and molecular mutagenesis 1992;20(1):39-43.
1992: John Ashby; P A Lefevre
Mitogenesis, micronuclei, and carcinogenesis in the rat liver: some basic inconsistencies.
Environmental and molecular mutagenesis 1992;20(1):29-38.
1992: John Ashby
Use of short-term tests in determining the genotoxicity or nongenotoxicity of chemicals.
IARC scientific publications 1992;(116):135-64.
1992: John Ashby; U Leigibel
Transgenic mouse mutation assays: potential for confusion of genotoxic and non-genotoxic carcinogenesis: a proposed solution.
Environmental and molecular mutagenesis 1992;20(3):145-7.
1991: John Ashby
Aspects of database construction and interrogation of relevance to the accurate prediction of rodent carcinogenicity and mutagenicity.
Environmental health perspectives 1991;96():97-100.
1991: John Ashby; Paul A Lefevre; Helen Tinwell; Gunnar Brunborg; Peter Schmezer; Beatrice L Pool-Zobel; R Shanu-Wilson; Jørn Holme; E J Soderlund; D Gulati
The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine.
Mutation research 1991;250(1-2):115-33.
1991: John Ashby; R S Morrod
Detection of human carcinogens.
Nature 1991;352(6332):185-6.
1991: John Ashby; P A Lefevre; T Shank; J Lewtas; J E Gallagher
Relative sensitivity of 32P-postlabelling of DNA and the autoradiographic UDS assay in the liver of mice exposed to 2-acetylaminofluorene (2AAF).
Mutation research 1991;252(3):259-68.
1991: J E Gallagher; T Shank; J Lewtas; P A Lefevre; John Ashby
Relative sensitivity of 32P-postlabelling of DNA and the autoradiographic UDS assay in the liver of rats exposed to 2-acetylaminofluorene (2AAF).
Mutation research 1991;252(3):247-57.
1991: John Ashby; Helen Tinwell; R D Callander; N Clare
Genetic activity of the human carcinogen sulphur mustard towards Salmonella and the mouse bone marrow.
Mutation research 1991;257(3):307-11.
1991: Raymond W Tennant; John Ashby
Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program.
Mutation research 1991;257(3):209-27.
1991: Helen Tinwell; John Ashby
Micronucleus morphology as a means to distinguish aneugens and clastogens in the mouse bone marrow micronucleus assay.
Mutagenesis 1991;6(3):193-8.
1991: D Scott; S M Galloway; R R Marshall; M Ishidate; D Brusick; John Ashby; B C Myhr
International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9.
Mutation research 1991;257(2):147-205.
1991: Ian Kimber; S Quirke; M Cumberbatch; John Ashby; D Paton; R D Aldridge; J A Hunter; M H Beck
Lymphocyte transformation and thiuram sensitization.
Contact dermatitis 1991;24(3):164-71.
1991: Helen Tinwell; John Ashby
Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay.
Environmental and molecular mutagenesis 1991;17(3):152-4.
1990: John Ashby; N G Doerrer; F G Flamm; J E Harris; D H Hughes; F R Johannsen; S C Lewis; N D Krivanek; J F McCarthy; R J Moolenaar
A scheme for classifying carcinogens.
Regulatory toxicology and pharmacology : RTP 1990;12(3 Pt 1):270-95.
1990: John Ashby; Helen Tinwell; R D Callander
Activity of urethane and N,N-dimethylurethane in the mouse bone-marrow micronucleus assay: equivalence of oral and intraperitoneal routes of exposure.
Mutation research 1990;245(3):227-30.
1990: Helen Tinwell; John Ashby
Inactivity of copper sulphate in a mouse bone-marrow micronucleus assay.
Mutation research 1990;245(3):223-6.
1990: John Ashby; Paul A Lefevre; Clifford R Elcombe
Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo.
Mutagenesis 1990;5(5):515-8.
1990: John Ashby; Helen Tinwell; D Gulati; J A Heddle
Overview of the study in relation to protocol design for the rodent bone-marrow micronucleus assay.
Mutation research 1990;234(3-4):223-48.
1990: John Ashby; Helen Tinwell
The serial dosing rodent bone-marrow micronucleus assay test protocol: context, purpose and design of the collaborative study.
Mutation research 1990;234(3-4):111-4.
1990: Helen Tinwell; L Bandara; John Ashby
Activity of DMBA, DMH and CP in triple- and single-dose rodent bone-marrow micronucleus assays.
Mutation research 1990;234(3-4):195-8.
1990: John Ashby; J E Gallagher; M Kohan; Helen Tinwell; Ian Kimber; D Paton; R D Callander; I Chouroulinkov
1-Chloromethylpyrene: a reference skin sensitizer and genotoxin.
Mutation research 1990;243(4):281-9.
1990: John Ashby; M Ishidate; G D Stoner; M A Morgan; F Ratpan; R D Callander
Studies on the genotoxicity of beryllium sulphate in vitro and in vivo.
Mutation research 1990;240(3):217-25.
1990: P A Lefevre; John Ashby
Activity of 2-acetylaminofluorene as a UDS inducing agent in B6C3F1 mouse hepatocytes in vitro.
Cell biology and toxicology 1990;6(1):15-21.
1990: Peter Schmezer; B L Pool; Paul A Lefevre; R D Callander; F Ratpan; Helen Tinwell; John Ashby
Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo.
Environmental and molecular mutagenesis 1990;15(4):190-7.
1990: Raymond W Tennant; Judson W Spalding; Stanley Stasiewicz; John Ashby
Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program.
Mutagenesis 1990;5(1):3-14.
1989: Helen Tinwell; John Ashby
Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays--including a triple dose study.
Mutagenesis 1989;4(6):476-81.
1989: John Ashby; C R Richardson; Helen Tinwell
Inactivity of ethyl acrylate in the mouse bone marrow micronucleus assay.
Mutagenesis 1989;4(4):283-5.
1989: John Ashby; Raymond W Tennant; Errol Zeiger; Stanley Stasiewicz
Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program.
Mutation research 1989;223(2):73-103.
1989: John Ashby
Origins of current uncertainties in carcinogen/mutagen screening.
Environmental and molecular mutagenesis 1989;14 Suppl 16():51-9.
1989: John Ashby; R Mohammed; P A Lefevre; L Bandara
Quinoline: unscheduled DNA synthesis and mitogenesis data from the rat liver in vivo.
Environmental and molecular mutagenesis 1989;14(4):221-8.
1988: John Ashby
An opinion on the significance of the 19 non-clastogenic gene-mutagens reported by Tennant et al. (1987).
Mutagenesis 1988;3(6):463-5.
1988: John Ashby; D Paton; R D Callander
Potent mutagenicity to Salmonella of an equimolar mixture of 52 chemicals used in five collaborative studies.
Mutagenesis 1988;3(4):345-7.
1988: John Ashby
Comparison of techniques for monitoring human exposure to genotoxic chemicals.
Mutation research 1988;204(3):543-51.
1988: I Braithwaite; John Ashby
A non-invasive micronucleus assay in the rat liver.
Mutation research 1988;203(1):23-32.
1988: John Ashby; R Mohammed
UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38.
Mutagenesis 1988;3(1):69-71.
1988: John Ashby; R D Callander; D Paton; Errol Zeiger; F Ratpan
Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene.
Environmental and molecular mutagenesis 1988;12(2):243-52.
1987: John Ashby; E Mirkova
The activity of MNNG in the mouse bone marrow micronucleus assay.
Mutagenesis 1987;2(3):199-204.
1987: R W Trueman; John Ashby
Lack of UDS activity in the livers of mice and rats exposed to dichloromethane.
Environmental and molecular mutagenesis 1987;10(2):189-95.
1985: John Ashby; C R Richardson; Paul A Lefevre; R D Callander; J A Styles
Chloracetamide-N-metholol: an example of an in vitro and in vivo clastogen which is non-mutagenic to Salmonella.
Mutation research 1985;156(1-2):19-32.
1984: John Ashby; R D Callander; Paul A Lefevre; D Paton; B Fishwick
Mutagenicity to Salmonella of the mono methylamino and N-cyanoethyl analogues of 4-dimethylaminoazobenzene (DAB) and 6-dimethylaminophenylazobenzthiazole (6BT).
Mutation research 1984;128(1):11-6.
1983: John Ashby; B M Elliott; Paul A Lefevre; J Styles; E Longstaff
Initiation/promotion versus complete carcinogenicity in the rodent liver.
Environmental health perspectives 1983;50():339-46.
1983: John Ashby; Paul A Lefevre; R D Callander
The possible role of azoreduction in the bacterial mutagenicity of 4-dimethylaminoazobenzene (DAB) and 2 of its analogues (6BT and 5I).
Mutation research 1983;116(3-4):271-9.
1983: John Ashby; D Paton; Paul A Lefevre
Cyclic amines as less mutagenic replacements for dimethyl amino (--NMe2) substituents on aromatic organic compounds: implications for carcinogenicity and toxicity.
Cancer letters 1983;17(3):263-71.
1982: John Ashby; D Paton; J A Styles; D Greatbanks; B Wright
Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.
Mutation research 1982;103(3-6):257-61.
1982: John Ashby; Paul A Lefevre; J A Styles; J Charlesworth; D Paton
Comparisons between carcinogenic potency and mutagenic potency to Salmonella in a series of derivatives of 4-dimethylaminoazobenzene (DAB).
Mutation research 1982;93(1):67-81.
1982: John Ashby; D Paton; Paul A Lefevre; J A Styles; F L Rose
Evaluation of two suggested methods of deactivating organic carcinogens by molecular modification.
Carcinogenesis 1982;3(11):1277-82.