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John Ashby

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
69
Tinwell, Helen
38
Lefevre, Paul
29
Odum, Jenny
16
Paton, D
10
Owens, William
10
Kimber, Ian
8
Joiner, Ronald
8
Soames, Anthony
8
Sumpter, John
6
Van Miller, John
5
Onyon, Lesley
5
Foster, John
4
Beresford, NA
4
Brooks, AN
4
Elcombe, Clifford

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Publications

TOP 3
Owens William; Gray L Earl; Zeiger Errol; Walker Michael; Yamasaki Kanji; Ashby John; Jacob Elard
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies.
Owens William; Zeiger Errol; Walker Michael; Ashby John; Onyon Lesley; Gray L Earl
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses. Phase 1: use of a potent agonist and a potent antagonist to test the standardized protocol.
Stuckey Ruth; Aldridge Tom; Lim Fei Ling; Moore David J; Tinwell Helen; Doherty Nicola; Davies Reginald; Smith Andrew G; Kimber Ian; Ashby John; Orphanides George; Moggs Jonathan G
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.

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All Publications

2007: Owens William; Gray L Earl; Zeiger Errol; Walker Michael; Yamasaki Kanji; Ashby John; Jacob Elard
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies.
Environmental health perspectives 2007;115(5):671-8.
2006: Owens William; Zeiger Errol; Walker Michael; Ashby John; Onyon Lesley; Gray L Earl
The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses. Phase 1: use of a potent agonist and a potent antagonist to test the standardized protocol.
Environmental health perspectives 2006;114(8):1259-65.
2006: Stuckey Ruth; Aldridge Tom; Lim Fei Ling; Moore David J; Tinwell Helen; Doherty Nicola; Davies Reginald; Smith Andrew G; Kimber Ian; Ashby John; Orphanides George; Moggs Jonathan G
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
Molecular and cellular endocrinology 2006;253(1-2):22-9.
2004: Ashby J; Odum J
Gene expression changes in the immature rat uterus: effects of uterotrophic and sub-uterotrophic doses of bisphenol A.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):458-67.
2004: Moggs Jonathan G; Tinwell Helen; Spurway Tracey; Chang Hur-Song; Pate Ian; Lim Fei Ling; Moore David J; Soames Anthony; Stuckey Ruth; Currie Richard; Zhu Tong; Kimber Ian; Ashby John; Orphanides George
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.
Environmental health perspectives 2004;112(16):1589-606.
2004: Moggs Jonathan G; Ashby John; Tinwell Helen; Lim Fei Ling; Moore David J; Kimber Ian; Orphanides George
The need to decide if all estrogens are intrinsically similar.
Environmental health perspectives 2004;112(11):1137-42.
2004: Ashby John; Tinwell Helen; Odum Jenny; Lefevre Paul
Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities.
Environmental health perspectives 2004;112(8):847-53.
2004: Tinwell Helen; Ashby John
Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens.
Environmental health perspectives 2004;112(5):575-82.
2004: Ashby J; Lefevre P A; Tinwell H; Odum J; Owens W
Testosterone-stimulated weanlings as an alternative to castrated male rats in the Hershberger anti-androgen assay.
Regulatory toxicology and pharmacology : RTP 2004;39(2):229-38.
2003: Ashby John
Problems associated with the recognition and confirmation of low-dose endocrine toxicities.
Nonlinearity in biology, toxicology, medicine 2003;1(4):439-53.
2003: Ashby John; Owens William; Odum Jenny; Tinwell Helen
The intact immature rodent uterotrophic bioassay: possible effects on assay sensitivity of vomeronasal signals from male rodents and strain differences.
Environmental health perspectives 2003;111(12):1568-70.
2003: Owens William; Ashby John; Odum Jenny; Onyon Lesley
The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses.
Environmental health perspectives 2003;111(12):1559-67.
2003: Kanno Jun; Onyon Lesley; Peddada Shyamal; Ashby John; Jacob Elard; Owens William
The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies.
Environmental health perspectives 2003;111(12):1550-8.
2003: Kanno Jun; Onyon Lesley; Peddada Shyamal; Ashby John; Jacob Elard; Owens William
The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies.
Environmental health perspectives 2003;111(12):1530-49.
2003: Ashby John; Pate Ian; Tinwell Helen
Reported seasonal dependence of herbicide developmental toxicity in mice.
Environmental health perspectives 2003;111(9):A450-1.
2003: Ashby J; Tinwell H; Lefevre P A; Joiner R; Haseman J
The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):129-38.
2003: Ashby John
The leading role and responsibility of the international scientific community in test development.
Toxicology letters 2003;140-141():37-42.
2003: Lewis Richard W; Brooks Nigel; Milburn Gillian M; Soames Anthony; Stone Susan; Hall Michael; Ashby John
The effects of the phytoestrogen genistein on the postnatal development of the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(1):74-83.
2002: Ashby John
Scientific issues associated with the validation of in vitro and in vivo methods for assessing endocrine disrupting chemicals.
Toxicology 2002;181-182():389-97.
2002: Tinwell H; Haseman J; Lefevre P A; Wallis N; Ashby J
Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):339-48.
2002: Odum J; Lefevre P A; Tinwell H; Van Miller J P; Joiner R L; Chapin R E; Wallis N T; Ashby J
Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):147-63.
2002: Ashby J; Tinwell H; Stevens J; Pastoor T; Breckenridge C B
The effects of atrazine on the sexual maturation of female rats.
Regulatory toxicology and pharmacology : RTP 2002;35(3):468-73.
2002: Ashby J; Owens W; Deghenghi R; Odum J
Concept evaluation: an assay for receptor-mediated and biochemical antiestrogens using pubertal rats.
Regulatory toxicology and pharmacology : RTP 2002;35(3):393-7.
2002: Tinwell Helen; Lefevre Paul A; Moffat Graeme J; Burns A; Odum Jenny; Spurway T D; Orphanides George; Ashby John
Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.
Environmental health perspectives 2002;110(5):533-6.
2002: Ashby John; Owens W; Lefevre P A
Concept evaluation: androgen-stimulated immature intact male rats as an assay for antiandrogens.
Regulatory toxicology and pharmacology : RTP 2002;35(2 Pt 1):280-5.
2002: Elcombe Clifford R; Odum Jenny; Foster John R; Stone Susan; Hasmall Susan; Soames Anthony R; Kimber Ian; Ashby John
Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.
Environmental health perspectives 2002;110(4):363-75.
2002: Odum J; Ashby John
Detection of aromatase inhibitors in vitro using rat ovary microsomes.
Toxicology letters 2002;129(1-2):119-22.
2001: Ashby J; Tinwell H; Plautz J; Twomey K; Lefevre P A
Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S.
Regulatory toxicology and pharmacology : RTP 2001;34(3):287-91.
2001: Ashby J
Mouse uterine carcinogenicity of genistein: the currently most secure example of non-genotoxic rodent carcinogenicity?
Mutation research 2001;483(1-2):107-8.
2001: Ashby J; Tinwell H; Odum J
DNA adducts, estrogenicity and rodent diets.
Mutation research 2001;483(1-2):105-6.
2001: Ashby J; Lefevre P A; Deghenghi R; Wallis N
Replacement of surgical castration by GnRH-inhibition or Leydig cell ablation in the male rat Hershberger antiandrogen assay.
Regulatory toxicology and pharmacology : RTP 2001;34(2):188-203.
2001: Moffat G J; Burns A; Van Miller J; Joiner R; Ashby J
Glucuronidation of nonylphenol and octylphenol eliminates their ability to activate transcription via the estrogen receptor.
Regulatory toxicology and pharmacology : RTP 2001;34(2):182-7.
2001: Ashby J; Lefevre P A
Replacement of surgical castration by GnRH inhibition for rat prostate androgen receptor preparations.
Journal of applied toxicology : JAT 2001;21(5):353-4.
2001: Kanno J; Onyon L; Haseman J; Fenner-Crisp P; Ashby J; Owens W;
The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1.
Environmental health perspectives 2001;109(8):785-94.
2001: Ashby J; Tinwell H
Continuing ability of the rodent bone marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals.
Mutation research 2001;478(1-2):211-3.
2001: Warbrick E V; Dearman R J; Ashby J; Schmezer P; Kimber I
Preliminary assessment of the skin sensitizing activity of selected rodent carcinogens using the local lymph node assay.
Toxicology 2001;163(1):63-9.
2001: Odum J; Tinwell H; Jones K; Van Miller J P; Joiner R L; Tobin G; Kawasaki H; Deghenghi R; Ashby J
Effect of rodent diets on the sexual development of the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2001;61(1):115-27.
2001: Elsby R; Maggs J L; Ashby J; Park B K
Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans.
The Journal of pharmacology and experimental therapeutics 2001;297(1):103-13.
2001: Ashby J
Testing for endocrine disruption post-EDSTAC: extrapolation of low dose rodent effects to humans.
Toxicology letters 2001;120(1-3):233-42.
2001: Tinwell H; Brinkworth M H; Ashby J
Further evidence for the rodent bone marrow micronucleus assay acting as a sensitive predictor of the possible germ cell mutagenicity of chemicals.
Mutation research 2001;473(2):259-61.
2001: Elsby R; Maggs J L; Ashby J; Paton D; Sumpter J P; Park B K
Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay.
The Journal of pharmacology and experimental therapeutics 2001;296(2):329-37.
2001: Odum J; Tinwell H; Van Miller J; Joiner R; Ashby J
The uterotrophic activity of nonylphenol in the rat is not mediated by aromatase enzyme induction.
Toxicology letters 2001;118(3):165-9.
2000: Elsby R; Ashby J; Sumpter J P; Brooks A N; Pennie W D; Maggs J L; Lefevre P A; Odum J; Beresford N; Paton D; Park B K
Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.
Biochemical pharmacology 2000;60(10):1519-30.
2000: Ashby J; Tinwell H; Odum J; Kimber I; Brooks A N; Pate I; Boyle C C
Diet and the aetiology of temporal advances in human and rodent sexual development.
Journal of applied toxicology : JAT 2000;20(5):343-7.
2000: Tinwell H; Joiner R; Pate I; Soames A; Foster J; Ashby J
Uterotrophic activity of bisphenol A in the immature mouse.
Regulatory toxicology and pharmacology : RTP 2000;32(1):118-26.
2000: Odum J; Ashby J
Neonatal exposure of male rats to nonylphenol has no effect on the reproductive tract.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(2):400-4.
2000: Tinwell H; Soames A R; Foster J R; Ashby J
Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays.
Environmental health perspectives 2000;108(7):631-4.
2000: Ashby J; Odum J; Paton D; Lefevre P A; Beresford N; Sumpter J P
Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3, 4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays.
Toxicology letters 2000;115(3):231-8.
2000: Ashby J; Lefevre P A
The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators.
Journal of applied toxicology : JAT 2000;20(1):35-47.
1999: Slater I; Odum J; Ashby J
Resveratrol and red wine consumption.
Human & experimental toxicology 1999;18(10):625-6.
1999: Ashby J; Tinwell H; Haseman J
Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero.
Regulatory toxicology and pharmacology : RTP 1999;30(2 Pt 1):156-66.
1999: Ashby J; Tinwell H; Soames A; Foster J
Induction of hyperplasia and increased DNA content in the uterus of immature rats exposed to coumestrol.
Environmental health perspectives 1999;107(10):819-22.
1999: Odum J; Pyrah I T; Soames A R; Foster J R; Van Miller J P; Joiner R L; Ashby J
Effects of p-nonylphenol (NP) and diethylstilboestrol (DES) on the Alderley Park (Alpk) rat: comparison of mammary gland and uterus sensitivity following oral gavage or implanted mini-pumps.
Journal of applied toxicology : JAT 1999;19(5):367-78.
1999: Odum J; Pyrah I T; Foster J R; Van Miller J P; Joiner R L; Ashby J
Comparative activities of p-nonylphenol and diethylstilbestrol in noble rat mammary gland and uterotrophic assays.
Regulatory toxicology and pharmacology : RTP 1999;29(2 Pt 1):184-95.
1999: Ashby J; Tinwell H; Pennie W; Brooks A N; Lefevre P A; Beresford N; Sumpter J P
Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects.
Journal of applied toxicology : JAT 1999;19(1):39-45.
1999: Fletcher K; Soames A R; Tinwell H; Lefevre P A; Ashby J
Hepatic gene mutations induced in Big Blue rats by both the potent rat liver azo-carcinogen 6BT and its reported noncarcinogenic analogue 5BT.
Environmental and molecular mutagenesis 1999;34(2-3):148-53.
1998: Routledge E J; Parker J; Odum J; Ashby J; Sumpter J P
Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic.
Toxicology and applied pharmacology 1998;153(1):12-9.
1998: Ashby J; Tinwell H
Oestrogenic activity of burgen bread to female rats.
Human & experimental toxicology 1998;17(11):598-9.
1998: Ashby J; Tinwell H
Uterotrophic activity of bisphenol A in the immature rat.
Environmental health perspectives 1998;106(11):719-20.
1998: Fletcher K; Tinwell H; Ashby J
Mutagenicity of the human bladder carcinogen 4-aminobiphenyl to the bladder of MutaMouse transgenic mice.
Mutation research 1998;400(1-2):245-50.
1998: Williams C V; Fletcher K; Tinwell H; Ashby J
Mutagenicity of ethyl carbamate to lacZ- transgenic mice.
Mutagenesis 1998;13(2):133-7.
1998: Tinwell H; Lefevre P A; Ashby J
Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of MutaMouse mice.
Environmental and molecular mutagenesis 1998;32(2):163-72.
1997: Ashby J; Fletcher K; Williams C; Odum J; Tinwell H
Lack of activity of estradiol in rodent bone marrow micronucleus assays.
Mutation research 1997;395(1):83-8.
1997: Ashby J; Lefevre P A
The weanling male rat as an assay for endocrine disruption: preliminary observations.
Regulatory toxicology and pharmacology : RTP 1997;26(3):330-7.
1997: Ashby J; Tinwell H; Lefevre P A; Williams J; Kier L; Adler I D; Clapp M J
Evaluation of the mutagenicity of acetochlor to male rat germ cells.
Mutation research 1997;393(3):263-81.
1997: Ashby J; Tinwell H; Lefevre P A; Odum J; Paton D; Millward S W; Tittensor S; Brooks A N
Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):102-18.
1997: Ashby J; Lefevre P A; Odum J; Tinwell H; Kennedy S J; Beresford N; Sumpter J P
Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents.
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):96-101.
1997: Ashby J; Odum J; Tinwell H; Lefevre P A
Assessing the risks of adverse endocrine-mediated effects: where to from here?
Regulatory toxicology and pharmacology : RTP 1997;26(1 Pt 1):80-93.
1997: Ashby J; Odum J; Foster J R
Activity of raloxifene in immature and ovariectomized rat uterotrophic assays.
Regulatory toxicology and pharmacology : RTP 1997;25(3):226-31.
1997: Yendle J E; Tinwell H; Elliott B M; Ashby J
The genetic toxicity of time: importance of DNA-unwinding time to the outcome of single-cell gel electrophoresis assays.
Mutation research 1997;375(2):125-36.
1997: Odum J; Lefevre P A; Tittensor S; Paton D; Routledge E J; Beresford N A; Sumpter J P; Ashby J
The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay.
Regulatory toxicology and pharmacology : RTP 1997;25(2):176-88.
1997: Ashby J
Identifying potential human carcinogens--the role of genetically altered rodents.
Toxicologic pathology 1997;25(2):241-3.
1997: Tinwell H; Lefevre P; Williams C V; Ashby J
The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay.
Mutation research 1997;388(2-3):179-85.
1997: Ashby J; Gorelick N J; Shelby M D
Mutation assays in male germ cells from transgenic mice: overview of study and conclusions.
Mutation research 1997;388(2-3):111-22.
1997: Ashby J; Lefevre P A; Odum J; Harris C A; Routledge E J; Sumpter J P
Synergy between synthetic oestrogens?
Nature 1997;385(6616):494.
1997: Lefevre P A; Tinwell H; Ashby J
Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic (lacI) rats: consideration of a reduced mutation assay protocol.
Mutagenesis 1997;12(1):45-7.
1996: Ashby J; Lefevre P A; Elliott B M; Clapp M J
Methyl methanesulphonate (MMS) as a resource conserving and reliable positive control agent for male rat and male mouse dominant lethal assays.
Mutagenesis 1996;11(6):611-3.
1996: Ashby J
Prediction of rodent carcinogenicity for 30 chemicals.
Environmental health perspectives 1996;104 Suppl 5():1101-4.
1996: Tinwell H; Ashby J; Williams C V
Presence of alpha-lactose in some batches of proprietary LB broth: relevance to the MutaMouse lacZ gene mutation assay.
Mutation research 1996;358(1):123-4.
1996: Tinwell H; Yendle J; Ashby J
Mutagenicity to the mouse bone marrow by the mouse germ cell mutagen N-propyl-N-nitrosourea.
Mutation research 1996;370(3-4):141-3.
1996: Zeiger E; Ashby J; Bakale G; Enslein K; Klopman G; Rosenkranz H S
Prediction of Salmonella mutagenicity.
Mutagenesis 1996;11(5):471-84.
1996: Ashby J; Kier L; Wilson A G; Green T; Lefevre P A; Tinwell H; Willis G A; Heydens W F; Clapp M J
Evaluation of the potential carcinogenicity and genetic toxicity to humans of the herbicide acetochlor.
Human & experimental toxicology 1996;15(9):702-35.
1996: Tinwell H; Clapp M J; Ashby J
Fate of unfertilized ova in male rodent dominant lethal assays: extension of the studies by Kratochvilova.
Mutation research 1996;368(3-4):309-17.
1996: Ashby J
Alternatives to the 2-species bioassay for the identification of potential human carcinogens.
Human & experimental toxicology 1996;15(3):183-202.
1996: Ashby J
Assessing chemicals for estrogenic/hormone-disrupting properties: lessons from carcinogenicity assessment.
Environmental health perspectives 1996;104(2):132-4.
1996: Ashby J
Cost-effective methods for identifying carcinogens.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(2-3):167.
1996: Ashby J
Series: current issues in mutagenesis and carcinogenesis, No. 66. Lijinsky's observation that the spontaneous tumour incidence in F334 rats is unaffected by prior damage to DNA.
Mutation research 1996;349(2):289-90.
1996: Tinwell H; Paton D; Guttenplan J B; Ashby J
Unexpected genetic toxicity to rodents of the N',N'-dimethyl analogues of MNU and ENU.
Environmental and molecular mutagenesis 1996;27(3):202-10.
1995: Ashby J
Rodent mutation assay data presentation and statistical assessment.
Mutation research 1995;331(2):233-5.
1995: Tinwell H; Liegibel U; Krebs O; Schmezer P; Favor J; Ashby J
Comparison of lacI and lacZ transgenic mouse mutation assays: an EU-sponsored interlaboratory study.
Mutation research 1995;335(2):185-90.
1995: Ashby J; Hilton J; Dearman R J; Kimber I
Streptozotocin: inherent but not expressed skin sensitizing activity.
Contact dermatitis 1995;33(3):165-7.
1995: Ashby J; Paton D
Chemicals for evaluating the sensitivity and specificity of reduced/transgenic rodent cancer bioassay protocols.
Mutation research 1995;331(1):27-38.
1995: Ashby J; Clapp M J
The rodent dominant lethal assay: a proposed format for data presentation that alerts to pseudo-dominant lethal effects.
Mutation research 1995;330(1-2):209-18.
1995: Ashby J
Druckrey's definition of 'genotoxic'.
Mutation research 1995;329(2):225.
1995: Morrison V; Tinwell H; Ashby J
Consideration of the liver of embryonic lacZ transgenic mice as an analogue of the mouse coat colour spot test: preliminary data and technical problems.
Mutation research 1995;329(2):107-12.
1995: James N H; Ashby J; Roberts R A
Enhanced hepatocyte colony growth in soft agar after in vivo treatment with a genotoxic carcinogen: a potential assay for hepatocarcinogens?
Cancer letters 1995;93(1):121-8.
1995: Ashby J; Tinwell H
Current issues in mutagenesis and carcinogenesis, No. 55. Activity of etoposide in the mouse bone marrow micronucleus test: independence of route of exposure.
Mutation research 1995;328(2):243-44.
1995: Ashby J
Series: current issues in mutagenesis and carcinogenesis, No. 54. Rodent germ cell mutagens and their activity in the rodent bone marrow micronucleus assay.
Mutation research 1995;328(2):239-41.
1995: Ashby J; Tinwell H
A sequential approach to testing with the rodent bone marrow micronucleus assay--obviation of the need for statistical analyses of data.
Mutation research 1995;327(1-2):49-55.
1994: Ashby J; Brady A; Elcombe C R; Elliott B M; Ishmael J; Odum J; Tugwood J D; Kettle S; Purchase I F
Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis.
Human & experimental toxicology 1994;13 Suppl 2():S1-117.
1994: Lefevre P A; Tinwell H; Galloway S M; Hill R; Mackay J M; Elcombe C R; Foster J; Randall V; Callander R D; Ashby J
Evaluation of the genetic toxicity of the peroxisome proliferator and carcinogen methyl clofenapate, including assays using Muta Mouse and Big Blue transgenic mice.
Human & experimental toxicology 1994;13(11):764-75.
1994: Ashby J
Series: current issues in mutagenesis and carcinogenesis, No. 51. Dose-level selection for in vivo genetic toxicity assays.
Mutation research 1994;311(1):165.
1994: Ashby J; Short J M; Jones N J; Lefevre P A; Provost G S; Rogers B J; Martin E A; Parry J M; Burnette K; Glickman B W
Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction.
Carcinogenesis 1994;15(10):2291-6.
1994: Tinwell H; Ashby J
Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment.
Environmental health perspectives 1994;102(9):758-62.
1994: Tinwell H; Ashby J
Genetic toxicity and potential carcinogenicity of taxol.
Carcinogenesis 1994;15(8):1499-501.
1994: Ashby J
The genotoxicity of 1,4-dioxane.
Mutation research 1994;322(2):141-2.
1994: Ashby J; Tinwell H; Weaver R; Cullis P M
Similar activity of chlorambucil and its spermidine conjugate in the mouse bone marrow micronucleus assay.
Mutagenesis 1994;9(4):391-2.
1994: Ashby J
Regulatory requirement for three dose levels and proof of tissue localisation in rodent genetic toxicity assays--a call for supporting data.
Mutation research 1994;308(2):243-4.
1994: Ashby J
Propositions in genetic toxicology and their erasure.
Mutation research 1994;308(1):113-4.
1994: Ashby J
Statistical versus biological significance of genetic toxicity data.
Mutation research 1994;308(1):109-10.
1994: Tinwell H; Lefevre P A; Ashby J
Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice.
Mutation research 1994;307(2):501-8.
1994: Ashby J
Benzyl acetate: from mutagenic carcinogen to non-mutagenic non-carcinogenic in 7 years?
Mutation research 1994;306(1):107-9.
1994: Ashby J
International Commission for Protection Against Environmental Mutagens and Carcinogens. Two million rodent carcinogens? The role of SAR and QSAR in their detection.
Mutation research 1994;305(1):3-12.
1994: Ashby J; Tennant R W
Prediction of rodent carcinogenicity for 44 chemicals: results.
Mutagenesis 1994;9(1):7-15.
1994: Ashby J; Tinwell H; Glover P; Poorman-Allen P; Krehl R; Callander R D; Clive D
Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.
Environmental and molecular mutagenesis 1994;24(1):51-60.
1993: Doyle C E; Mackay J M; Ashby J
Failure of N-acetylcysteine to protect the mouse bone marrow against the clastogenicity of 7,12-dimethylbenzanthracene.
Mutagenesis 1993;8(6):583-4.
1993: Ashby J; Purchase I F
Will all chemicals be carcinogenic to rodents when adequately evaluated?
Mutagenesis 1993;8(6):489-93.
1993: Ashby J; Anwar W; Au W W; Massoud A; Gentile J M
Genetic toxicology in developing countries: comments and recommendations.
Environmental health perspectives 1993;101 Suppl 3():335-8.
1993: Ashby J; Brusick D; Myhr B C; Jones N J; Parry J M; Nesnow S; Paton D; Tinwell H; Rosenkranz H S; Curti S
Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z- mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assays.
Mutation research 1993;292(1):25-40.
1993: Ashby J
Treosulphan, myleran and butadiene: similarities and differences.
Mutation research 1993;300(2):77-8.
1993: Ashby J; Hilton J; Dearman R J; Callander R D; Kimber I
Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity.
Environmental health perspectives 1993;101(1):62-7.
1993: Ashby J; Paton D
The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures.
Mutation research 1993;286(1):3-74.
1993: Ashby J; Vogel E W; Tinwell H; Callander R D; Shuker D E
Mutagenicity to Salmonella, Drosophila and the mouse bone marrow of the human antineoplastic agent fotemustine: prediction of carcinogenic potency.
Mutation research 1993;286(1):101-9.
1993: Ashby J
Precedents or possibilities: which should guide the harmonization of mutagenicity test protocols and carcinogen prediction strategies?
Mutation research 1993;298(4):291-5.
1992: Ashby J; Purchase I F
Nongenotoxic carcinogens: an extension of the perspective provided by Perera.
Environmental health perspectives 1992;98():223-6.
1992: Liegibel U; Tinwell H; Callander R D; Schmezer P; Ashby J
Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin streptozotocin.
Mutagenesis 1992;7(6):471-4.
1992: Ashby J
Consideration of CASE predictions of genotoxic carcinogenesis for omeprazole, methapyrilene and azathioprine.
Mutation research 1992;272(1):1-7.
1992: Lefevre P; Ashby J
Mitogenic activity of quinoline to the rat, mouse, and guinea pig liver: empirical correlations with hepatic carcinogenicity.
Environmental and molecular mutagenesis 1992;20(1):39-43.
1992: Ashby J; Lefevre P A
Mitogenesis, micronuclei, and carcinogenesis in the rat liver: some basic inconsistencies.
Environmental and molecular mutagenesis 1992;20(1):29-38.
1992: Ashby J
Use of short-term tests in determining the genotoxicity or nongenotoxicity of chemicals.
IARC scientific publications 1992;(116):135-64.
1992: Ashby J; Leigibel U
Transgenic mouse mutation assays: potential for confusion of genotoxic and non-genotoxic carcinogenesis: a proposed solution.
Environmental and molecular mutagenesis 1992;20(3):145-7.
1991: Ashby J
Aspects of database construction and interrogation of relevance to the accurate prediction of rodent carcinogenicity and mutagenicity.
Environmental health perspectives 1991;96():97-100.
1991: Ashby J; Lefevre P A; Tinwell H; Brunborg G; Schmezer P; Pool-Zobel B; Shanu-Wilson R; Holme J A; Soderlund E J; Gulati D
The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine.
Mutation research 1991;250(1-2):115-33.
1991: Ashby J; Morrod R S
Detection of human carcinogens.
Nature 1991;352(6332):185-6.
1991: Ashby J; Lefevre P A; Shank T; Lewtas J; Gallagher J E
Relative sensitivity of 32P-postlabelling of DNA and the autoradiographic UDS assay in the liver of mice exposed to 2-acetylaminofluorene (2AAF).
Mutation research 1991;252(3):259-68.
1991: Gallagher J E; Shank T; Lewtas J; Lefevre P A; Ashby J
Relative sensitivity of 32P-postlabelling of DNA and the autoradiographic UDS assay in the liver of rats exposed to 2-acetylaminofluorene (2AAF).
Mutation research 1991;252(3):247-57.
1991: Ashby J; Tinwell H; Callander R D; Clare N
Genetic activity of the human carcinogen sulphur mustard towards Salmonella and the mouse bone marrow.
Mutation research 1991;257(3):307-11.
1991: Tennant R W; Ashby J
Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program.
Mutation research 1991;257(3):209-27.
1991: Tinwell H; Ashby J
Micronucleus morphology as a means to distinguish aneugens and clastogens in the mouse bone marrow micronucleus assay.
Mutagenesis 1991;6(3):193-8.
1991: Scott D; Galloway S M; Marshall R R; Ishidate M; Brusick D; Ashby J; Myhr B C
International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9.
Mutation research 1991;257(2):147-205.
1991: Kimber I; Quirke S; Cumberbatch M; Ashby J; Paton D; Aldridge R D; Hunter J A; Beck M H
Lymphocyte transformation and thiuram sensitization.
Contact dermatitis 1991;24(3):164-71.
1991: Tinwell H; Ashby J
Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay.
Environmental and molecular mutagenesis 1991;17(3):152-4.
1990: Ashby J; Doerrer N G; Flamm F G; Harris J E; Hughes D H; Johannsen F R; Lewis S C; Krivanek N D; McCarthy J F; Moolenaar R J
A scheme for classifying carcinogens.
Regulatory toxicology and pharmacology : RTP 1990;12(3 Pt 1):270-95.
1990: Ashby J; Tinwell H; Callander R D
Activity of urethane and N,N-dimethylurethane in the mouse bone-marrow micronucleus assay: equivalence of oral and intraperitoneal routes of exposure.
Mutation research 1990;245(3):227-30.
1990: Tinwell H; Ashby J
Inactivity of copper sulphate in a mouse bone-marrow micronucleus assay.
Mutation research 1990;245(3):223-6.
1990: Ashby J; Lefevre P A; Elcombe C R
Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo.
Mutagenesis 1990;5(5):515-8.
1990: Ashby J; Tinwell H; Gulati D; Heddle J A
Overview of the study in relation to protocol design for the rodent bone-marrow micronucleus assay.
Mutation research 1990;234(3-4):223-48.
1990: Ashby J; Tinwell H
The serial dosing rodent bone-marrow micronucleus assay test protocol: context, purpose and design of the collaborative study.
Mutation research 1990;234(3-4):111-4.
1990: Tinwell H; Bandara L; Ashby J
Activity of DMBA, DMH and CP in triple- and single-dose rodent bone-marrow micronucleus assays.
Mutation research 1990;234(3-4):195-8.
1990: Ashby J; Gallagher J E; Kohan M; Tinwell H; Kimber I; Paton D; Callander R D; Chouroulinkov I
1-Chloromethylpyrene: a reference skin sensitizer and genotoxin.
Mutation research 1990;243(4):281-9.
1990: Ashby J; Ishidate M; Stoner G D; Morgan M A; Ratpan F; Callander R D
Studies on the genotoxicity of beryllium sulphate in vitro and in vivo.
Mutation research 1990;240(3):217-25.
1990: Lefevre P A; Ashby J
Activity of 2-acetylaminofluorene as a UDS inducing agent in B6C3F1 mouse hepatocytes in vitro.
Cell biology and toxicology 1990;6(1):15-21.
1990: Tennant R W; Spalding J; Stasiewicz S; Ashby J
Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program.
Mutagenesis 1990;5(1):3-14.
1990: Schmezer P; Pool B L; Lefevre P A; Callander R D; Ratpan F; Tinwell H; Ashby J
Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo.
Environmental and molecular mutagenesis 1990;15(4):190-7.
1989: Tinwell H; Ashby J
Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays--including a triple dose study.
Mutagenesis 1989;4(6):476-81.
1989: Ashby J; Richardson C R; Tinwell H
Inactivity of ethyl acrylate in the mouse bone marrow micronucleus assay.
Mutagenesis 1989;4(4):283-5.
1989: Ashby J; Tennant R W; Zeiger E; Stasiewicz S
Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program.
Mutation research 1989;223(2):73-103.
1989: Ashby J
Origins of current uncertainties in carcinogen/mutagen screening.
Environmental and molecular mutagenesis 1989;14 Suppl 16():51-9.
1989: Ashby J; Mohammed R; Lefevre P A; Bandara L
Quinoline: unscheduled DNA synthesis and mitogenesis data from the rat liver in vivo.
Environmental and molecular mutagenesis 1989;14(4):221-8.
1988: Ashby J
An opinion on the significance of the 19 non-clastogenic gene-mutagens reported by Tennant et al. (1987).
Mutagenesis 1988;3(6):463-5.
1988: Ashby J; Paton D; Callander R D
Potent mutagenicity to Salmonella of an equimolar mixture of 52 chemicals used in five collaborative studies.
Mutagenesis 1988;3(4):345-7.
1988: Ashby J
Comparison of techniques for monitoring human exposure to genotoxic chemicals.
Mutation research 1988;204(3):543-51.
1988: Braithwaite I; Ashby J
A non-invasive micronucleus assay in the rat liver.
Mutation research 1988;203(1):23-32.
1988: Ashby J; Mohammed R
UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38.
Mutagenesis 1988;3(1):69-71.
1988: Ashby J; Callander R D; Paton D; Zeiger E; Ratpan F
Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene.
Environmental and molecular mutagenesis 1988;12(2):243-52.
1987: Ashby J; Mirkova E
The activity of MNNG in the mouse bone marrow micronucleus assay.
Mutagenesis 1987;2(3):199-204.
1987: Trueman R W; Ashby J
Lack of UDS activity in the livers of mice and rats exposed to dichloromethane.
Environmental and molecular mutagenesis 1987;10(2):189-95.
1985: Ashby J; Richardson C R; Lefevre P A; Callander R D; Styles J A
Chloracetamide-N-metholol: an example of an in vitro and in vivo clastogen which is non-mutagenic to Salmonella.
Mutation research 1985;156(1-2):19-32.
1984: Ashby J; Callander R D; Lefevre P A; Paton D; Fishwick B
Mutagenicity to Salmonella of the mono methylamino and N-cyanoethyl analogues of 4-dimethylaminoazobenzene (DAB) and 6-dimethylaminophenylazobenzthiazole (6BT).
Mutation research 1984;128(1):11-6.
1983: Ashby J; Elliott B M; Lefevre P A; Styles J; Longstaff E
Initiation/promotion versus complete carcinogenicity in the rodent liver.
Environmental health perspectives 1983;50():339-46.
1983: Ashby J; Lefevre P A; Callander R D
The possible role of azoreduction in the bacterial mutagenicity of 4-dimethylaminoazobenzene (DAB) and 2 of its analogues (6BT and 5I).
Mutation research 1983;116(3-4):271-9.
1983: Ashby J; Paton D; Lefevre P A
Cyclic amines as less mutagenic replacements for dimethyl amino (--NMe2) substituents on aromatic organic compounds: implications for carcinogenicity and toxicity.
Cancer letters 1983;17(3):263-71.
1982: Ashby J; Paton D; Styles J A; Greatbanks D; Wright B
Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.
Mutation research 1982;103(3-6):257-61.
1982: Ashby J; Lefevre P A; Styles J A; Charlesworth J; Paton D
Comparisons between carcinogenic potency and mutagenic potency to Salmonella in a series of derivatives of 4-dimethylaminoazobenzene (DAB).
Mutation research 1982;93(1):67-81.
1982: Ashby J; Paton D; Lefevre P A; Styles J A; Rose F L
Evaluation of two suggested methods of deactivating organic carcinogens by molecular modification.
Carcinogenesis 1982;3(11):1277-82.

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