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George Heigenhauser

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Brennan K Smith; Lawrence L Spriet; Brendon J Gurd; George J F Heigenhauser; James S Lally; Amy C Maher; Kazutaka Mukai; Graham P Holloway
AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.
Christopher G R Perry; Lawrence L Spriet; David C Wright; George J F Heigenhauser; Eric A F Herbst; Daniel A Kane; Daniel S Lark; Kazutaka Mukai; P Darrell Neufer; Graham P Holloway
Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle.
Heather M Logan-Sprenger; George J F Heigenhauser; Kieran J Killian; Lawrence L Spriet
Effects of dehydration during cycling on skeletal muscle metabolism in females.

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2013: Brennan K Smith; Lawrence L Spriet; Brendon J Gurd; George J F Heigenhauser; James S Lally; Amy C Maher; Kazutaka Mukai; Graham P Holloway
AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.
The Journal of physiology 2013;591(Pt 6):1551-61.
2012: Christopher G R Perry; Lawrence L Spriet; David C Wright; George J F Heigenhauser; Eric A F Herbst; Daniel A Kane; Daniel S Lark; Kazutaka Mukai; P Darrell Neufer; Graham P Holloway
Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle.
The Journal of physiology 2012;590(Pt 21):5475-86.
2012: Heather M Logan-Sprenger; George J F Heigenhauser; Kieran J Killian; Lawrence L Spriet
Effects of dehydration during cycling on skeletal muscle metabolism in females.
Medicine and science in sports and exercise 2012;44(10):1949-57.
2011: Lorenzo K Love; Nicolette S Bradley; Jon Choptiany; George J F Heigenhauser; J. Greig Inglis; Paul J LeBlanc; Sandra J Peters
The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(2):427-34.
2011: Brendon J Gurd; George J F Heigenhauser; Graham P Holloway; Jay T McFarlan; Chris D Moyes; Lawrence Spriet; Yuko Yoshida; Arend Bonen
Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(1):R67-75.
2011: Modest Vengust; C Kerr; Henry R Staempfli; J Pringle; George J F Heigenhauser; L Viel
Effect of frusemide on transvascular fluid fluxes across the lung in exercising horses.
Equine veterinary journal 2011;43(4):451-9.
2011: Michael Lindinger; George J F Heigenhauser
Comments on Point:Counterpoint: Muscle lactate and H⁺ production do/do not have a 1:1 association in skeletal muscle. Calculations of Robergs support the view of Vinnakota and Kushmerick.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;110(5):1493.
2010: Christopher G R Perry; James Lally; Graham P Holloway; George J F Heigenhauser; Arend Bonen; Lawrence L Spriet
Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle.
The Journal of physiology 2010;588(Pt 23):4795-810.
2010: Modest Vengust; Henry R Stämpfli; A N De Moraes; F Teixeiro-Neto; Laurent Viel; George J F Heigenhauser
Effects of chronic acetazolamide administration on gas exchange and acid-base control in pulmonary circulation in exercising horses.
Equine veterinary journal. Supplement 2010;(38):40-50.
2010: Jason L Talanian; Graham P Holloway; Laelie A Snook; George J F Heigenhauser; Arend Bonen; Lawrence L Spriet
Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2010;299(2):E180-8.
2010: Brendon J Gurd; Christopher G R Perry; George J F Heigenhauser; Lawrence L Spriet; Arend Bonen
High-intensity interval training increases SIRT1 activity in human skeletal muscle.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2010;35(3):350-7.
2010: Lisa M K Chin; George J F Heigenhauser; Donald H Paterson; John M Kowalchuk
Pulmonary O2 uptake and leg blood flow kinetics during moderate exercise are slowed by hyperventilation-induced hypocapnic alkalosis.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(6):1641-50.
2010: Joe Quadrilatero; Eric Bombardier; Sarah M Norris; Jason L Talanian; Matthew S Palmer; Heather M Logan; A Russell Tupling; George J F Heigenhauser; Lawrence L Spriet
Prolonged moderate-intensity aerobic exercise does not alter apoptotic signaling and DNA fragmentation in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E534-47.
2010: Lisa M K Chin; George J F Heigenhauser; Donald H Paterson; John M Kowalchuk
Effect of hyperventilation and prior heavy exercise on O2 uptake and muscle deoxygenation kinetics during transitions to moderate exercise.
European journal of applied physiology 2010;108(5):913-25.
2009: A Brianne Thrush; David N Brindley; Adrian Chabowski; George J F Heigenhauser; David J Dyck
Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation.
The Journal of clinical endocrinology and metabolism 2009;94(12):5053-61.
2009: J Kent Bigrigg; George J F Heigenhauser; J Greig Inglis; Paul J LeBlanc; Sandra J Peters
Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(3):R885-91.
2009: Brendon J Gurd; Sandra J Peters; George J F Heigenhauser; Paul J LeBlanc; Timothy J Doherty; Donald H Paterson; John M Kowalchuk
Prior heavy exercise elevates pyruvate dehydrogenase activity and muscle oxygenation and speeds O2 uptake kinetics during moderate exercise in older adults.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(3):R877-84.
2009: Amanda P Waller; Raymond J Geor; Lawrence L Spriet; George J F Heigenhauser; Michael Lindinger
Oral acetate supplementation after prolonged moderate intensity exercise enhances early muscle glycogen resynthesis in horses.
Experimental physiology 2009;94(8):888-98.
2009: Amanda P Waller; George J F Heigenhauser; Raymond J Geor; Lawrence L Spriet; Michael Lindinger
Fluid and electrolyte supplementation after prolonged moderate-intensity exercise enhances muscle glycogen resynthesis in Standardbred horses.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(1):91-100.
2008: Stuart D R Galloway; Jason L Talanian; Anna K Shoveller; George J F Heigenhauser; Lawrence L Spriet
Seven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(2):643-51.
2008: Michael Lindinger; George J F Heigenhauser
Last word on point:counterpoint: lactate is/is not the only physicochemical contributor to the acidosis of exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(1):369.
2008: Michael Lindinger; George J F Heigenhauser
Counterpoint: Lactic acid is not the only physicochemical contributor to the acidosis of exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(1):359-61; discussion 361-2.
2008: Graham P Holloway; Chris Perry; A Brianne Thrush; George J F Heigenhauser; David J Dyck; Arend Bonen; Lawrence L Spriet
PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein.
American journal of physiology. Endocrinology and metabolism 2008;294(6):E1060-9.
2008: A Brianne Thrush; George J F Heigenhauser; Kerry L Mullen; David C Wright; David J Dyck
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1205-12.
2008: Brendon J Gurd; Sandra J Peters; George J F Heigenhauser; Paul J LeBlanc; Timothy J Doherty; Donald H Paterson; John M Kowalchuk
O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(2):R577-84.
2008: Nicolette S Bradley; George J F Heigenhauser; Brian D Roy; Elizabeth M Staples; J. Greig Inglis; Paul J LeBlanc; Sandra J Peters
The acute effects of differential dietary fatty acids on human skeletal muscle pyruvate dehydrogenase activity.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(1):1-9.
2007: Lisa M K Chin; Ryan J Leigh; George J F Heigenhauser; Harry B Rossiter; Donald H Paterson; John M Kowalchuk
Hyperventilation-induced hypocapnic alkalosis slows the adaptation of pulmonary O2 uptake during the transition to moderate-intensity exercise.
The Journal of physiology 2007;583(Pt 1):351-64.
2007: Graham P Holloway; Jamie S V Lally; James G Nickerson; Hakam Alkhateeb; Laelie A Snook; George J F Heigenhauser; Jorge Calles-Escandon; Jan F C Glatz; Joost J F P Luiken; Lawrence L Spriet; Arend Bonen
Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle.
The Journal of physiology 2007;582(Pt 1):393-405.
2007: A Brianne Thrush; Adrian Chabowski; George J F Heigenhauser; Brian W McBride; Manun Or-Rashid; David J Dyck
Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(3):372-82.
2007: Graham P Holloway; A Brianne Thrush; George J F Heigenhauser; Narendra Tandon; David J Dyck; Arend Bonen; Lawrence L Spriet
Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1782-9.
2007: Trent Stellingwerff; George J F Heigenhauser; Lawrence L Spriet
Reply to letter "Pyruvate metabolism in working human skeletal muscle" by Henderson et al.
American journal of physiology. Endocrinology and metabolism 2007;292(4):E1238-9.
2007: Jason L Talanian; Stuart D R Galloway; George J F Heigenhauser; Arend Bonen; Lawrence L Spriet
Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(4):1439-47.
2007: Chris Perry; Jason L Talanian; George J F Heigenhauser; Lawrence L Spriet
The effects of training in hyperoxia vs. normoxia on skeletal muscle enzyme activities and exercise performance.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(3):1022-7.
2007: Flavia Meyer; Orlando Laitano; O Bar-Or; D McDougall; George J F Heigenhauser; G J F Heingenhauser
Effect of age and gender on sweat lactate and ammonia concentrations during exercise in the heat.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2007;40(1):135-43.
2006: Brendon J Gurd; Sandra J Peters; George J F Heigenhauser; Paul J LeBlanc; Timothy J Doherty; Donald H Paterson; John M Kowalchuk
Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O2 uptake kinetics during subsequent moderate-intensity exercise in healthy young adults.
The Journal of physiology 2006;577(Pt 3):985-96.
2006: Jason L Talanian; Rebecca J Tunstall; Matthew J Watt; Mylinh Duong; Chris Perry; Gregory R Steinberg; Bruce E Kemp; George J F Heigenhauser; Lawrence L Spriet
Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(4):R1094-9.
2006: Clinton R Bruce; A Brianne Thrush; Valerie A Mertz; Veronic Bezaire; Adrian Chabowski; George J F Heigenhauser; David J Dyck
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E99-E107.
2006: Kirsten A Burgomaster; George J F Heigenhauser; Martin J Gibala
Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(6):2041-7.
2006: Arend Bonen; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; George J F Heigenhauser
The fatty acid transporter FAT/CD36 is upregulated in subcutaneous and visceral adipose tissues in human obesity and type 2 diabetes.
International journal of obesity (2005) 2006;30(6):877-83.
2006: Trent Stellingwerff; Paul J LeBlanc; Melanie G Hollidge; George J F Heigenhauser; Lawrence L Spriet
Hyperoxia decreases muscle glycogenolysis, lactate production, and lactate efflux during steady-state exercise.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1180-90.
2006: Veronic Bezaire; Clinton R Bruce; George J F Heigenhauser; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; Arend Bonen; Lawrence L Spriet
Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation.
American journal of physiology. Endocrinology and metabolism 2006;290(3):E509-15.
2006: Graham P Holloway; Veronic Bezaire; George J F Heigenhauser; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; Arend Bonen; Lawrence L Spriet
Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise.
The Journal of physiology 2006;571(Pt 1):201-10.
2006: David J Dyck; George J F Heigenhauser; Clinton R Bruce
The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.
Acta physiologica (Oxford, England) 2006;186(1):5-16.
2005: Clinton R Bruce; Valerie A Mertz; George J F Heigenhauser; David J Dyck
The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects.
Diabetes 2005;54(11):3154-60.
2005: Michael Lindinger; John M Kowalchuk; George J F Heigenhauser
Applying physicochemical principles to skeletal muscle acid-base status.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(3):R891-4; author reply R904-910.
2005: Kirsten A Burgomaster; Scott C Hughes; George J F Heigenhauser; Suzanne N Bradwell; Martin J Gibala
Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(6):1985-90.
2005: Benjamin F Miller; Michael Lindinger; Jill A Fattor; Kevin A Jacobs; Paul J LeBlanc; Mylinh Duong; George J F Heigenhauser; George A Brooks
Hematological and acid-base changes in men during prolonged exercise with and without sodium-lactate infusion.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(3):856-65.
2005: Erin A Turvey; George J F Heigenhauser; Michelle L Parolin; Sandra J Peters
Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):350-5.
2005: Trent Stellingwerff; Lee Glazier; Matthew J Watt; Paul J LeBlanc; George J F Heigenhauser; Lawrence L Spriet
Effects of hyperoxia on skeletal muscle carbohydrate metabolism during transient and steady-state exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):250-6.
2005: Tanya L Pehleman; Sandra J Peters; George J F Heigenhauser; Lawrence L Spriet
Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):100-7.
2004: Paul J LeBlanc; Krista R Howarth; Martin J Gibala; George J F Heigenhauser
Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(6):2148-53.
2004: Marcus O'Neill; Matthew J Watt; George J F Heigenhauser; Lawrence L Spriet
Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(5):1938-45.
2004: Matthew J Watt; George J F Heigenhauser; Paul J LeBlanc; J. Greig Inglis; Lawrence L Spriet; Sandra J Peters
Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(4):1261-7.
2004: Gregory R Steinberg; Angela C Smith; Bryce J W van Denderen; Zhiping Chen; Sid Murthy; Duncan J Campbell; George J F Heigenhauser; David J Dyck; Bruce E Kemp
AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females.
The Journal of clinical endocrinology and metabolism 2004;89(9):4575-80.
2004: Krista R Howarth; Paul J LeBlanc; George J F Heigenhauser; Martin J Gibala
Effect of endurance training on muscle TCA cycle metabolism during exercise in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(2):579-84.
2004: Arend Bonen; Michelle L Parolin; Gregory R Steinberg; Jorge Calles-Escandon; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; George J F Heigenhauser; David J Dyck
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1144-6.
2004: Paul J LeBlanc; Sandra J Peters; Rebecca J Tunstall; David Cameron-Smith; George J F Heigenhauser
Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle.
The Journal of physiology 2004;557(Pt 2):559-70.
2004: Jeff G Richards; Arend Bonen; George J F Heigenhauser; Chris M Wood
Palmitate movement across red and white muscle membranes of rainbow trout.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(1):R46-53.
2004: Veronic Bezaire; George J F Heigenhauser; Lawrence L Spriet
Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2004;286(1):E85-91.
2003: Jeff G Richards; George J F Heigenhauser; Chris M Wood
Exercise and recovery metabolism in the Pacific spiny dogfish (Squalus acanthias).
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2003;173(6):463-74.
2003: Matthew J Watt; Gregory R Steinberg; George J F Heigenhauser; Lawrence L Spriet; David J Dyck
Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid.
American journal of physiology. Endocrinology and metabolism 2003;285(2):E412-9.
2003: Charles T Putman; Norman L Jones; George J F Heigenhauser
Effects of short-term training on plasma acid-base balance during incremental exercise in man.
The Journal of physiology 2003;550(Pt 2):585-603.
2003: Matthew J Watt; Trent Stellingwerff; George J F Heigenhauser; Lawrence L Spriet
Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle.
The Journal of physiology 2003;550(Pt 1):325-32.
2003: Matthew J Watt; George J F Heigenhauser; Marcus O'Neill; Lawrence L Spriet
Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(1):314-21.
2003: Nicholas E Kimber; George J F Heigenhauser; Lawrence L Spriet; David J Dyck
Skeletal muscle fat and carbohydrate metabolism during recovery from glycogen-depleting exercise in humans.
The Journal of physiology 2003;548(Pt 3):919-27.
2003: Trent Stellingwerff; Matthew J Watt; George J F Heigenhauser; Lawrence L Spriet
Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase.
American journal of physiology. Endocrinology and metabolism 2003;284(3):E589-96.
2003: Matthew J Watt; George J F Heigenhauser; Lawrence L Spriet
Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle.
The Journal of physiology 2003;547(Pt 1):301-8.
2002: Matthew J Watt; George J F Heigenhauser; Trent Stellingwerff; Mark Hargreaves; Lawrence L Spriet
Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man.
The Journal of physiology 2002;544(Pt 3):949-56.
2002: Paul J LeBlanc; Michelle L Parolin; Norman L Jones; George J F Heigenhauser
Effects of respiratory alkalosis on human skeletal muscle metabolism at the onset of submaximal exercise.
The Journal of physiology 2002;544(Pt 1):303-13.
2002: Matthew J Watt; George J F Heigenhauser; Lawrence L Spriet
Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(4):1185-95.
2002: Norman L Jones; George J F Heigenhauser
VO2max and lactate production are not normal in all patients with chronic fatigue.
Medicine and science in sports and exercise 2002;34(7):1215; author reply 1215-6.
2002: Jeff G Richards; Ashley J Mercado; Cheryl A Clayton; George J F Heigenhauser; Chris M Wood
Substrate utilization during graded aerobic exercise in rainbow trout.
The Journal of experimental biology 2002;205(Pt 14):2067-77.
2002: Gregory R Steinberg; Michelle L Parolin; George J F Heigenhauser; David J Dyck
Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance.
American journal of physiology. Endocrinology and metabolism 2002;283(1):E187-92.
2002: Ingrid Savasi; Melissa K Evans; George J F Heigenhauser; Lawrence L Spriet
Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.
American journal of physiology. Endocrinology and metabolism 2002;283(1):E108-15.
2002: Matthew J Watt; George J F Heigenhauser; David J Dyck; Lawrence L Spriet
Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man.
The Journal of physiology 2002;541(Pt 3):969-78.
2002: Lawrence L Spriet; George J F Heigenhauser
Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise.
Exercise and sport sciences reviews 2002;30(2):91-5.
2002: Jeff G Richards; George J F Heigenhauser; Chris M Wood
Glycogen phosphorylase and pyruvate dehydrogenase transformation in white muscle of trout during high-intensity exercise.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R828-36.
2002: Jeff G Richards; George J F Heigenhauser; Chris M Wood
Lipid oxidation fuels recovery from exhaustive exercise in white muscle of rainbow trout.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(1):R89-99.
2001: Sandra J Peters; Robert Harris; P Wu; T L Pehleman; George J F Heigenhauser; Lawrence L Spriet
Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1151-8.
2001: M K Evans; I Savasi; George J F Heigenhauser; Lawrence L Spriet
Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1144-50.
2001: Wendy J McFarlane; George J F Heigenhauser; D Gordon McDonald
Creatine supplementation affects sprint endurance in juvenile rainbow trout.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;130(4):857-66.
2001: Michael C Riddell; Oded Bar-Or; Boguslaw Wilk; Michelle L Parolin; George J F Heigenhauser
Substrate utilization during exercise with glucose and glucose plus fructose ingestion in boys ages 10--14 yr.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(3):903-11.
2001: Sandra J Peters; Robert Harris; George J F Heigenhauser; Lawrence L Spriet
Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(3):R661-8.
2000: LM Odland; George J F Heigenhauser; Lawrence L Spriet
Effects of high fat provision on muscle PDH activation and malonyl-CoA content in moderate exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(6):2352-8.
2000: Michael C Riddell; Oded Bar-Or; Henry P Schwarcz; George J F Heigenhauser
Substrate utilization in boys during exercise with [13C]-glucose ingestion.
European journal of applied physiology 2000;83(4 -5):441-8.
2000: Michelle L Parolin; Lawrence L Spriet; E Hultman; MP Matsos; MG Hollidge-Horvat; Norman L Jones; George J F Heigenhauser
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
American journal of physiology. Endocrinology and metabolism 2000;279(4):E752-61.
2000: TA St Amand; Lawrence L Spriet; Norman L Jones; George J F Heigenhauser
Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet.
American journal of physiology. Endocrinology and metabolism 2000;279(2):E275-83.
2000: J L Walker; George J F Heigenhauser; E Hultman; Lawrence L Spriet
Dietary carbohydrate, muscle glycogen content, and endurance performance in well-trained women.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(6):2151-8.
2000: Lawrence L Spriet; RA Howlett; George J F Heigenhauser
An enzymatic approach to lactate production in human skeletal muscle during exercise.
Medicine and science in sports and exercise 2000;32(4):756-63.
2000: Michael C Riddell; Oded Bar-Or; MG Hollidge-Horvat; Henry P Schwarcz; George J F Heigenhauser
Glucose ingestion and substrate utilization during exercise in boys with IDDM.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(4):1239-46.
2000: Michelle L Parolin; Lawrence L Spriet; E Hultman; MG Hollidge-Horvat; Norman L Jones; George J F Heigenhauser
Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E522-34.
2000: E C Starritt; RA Howlett; George J F Heigenhauser; Lawrence L Spriet
Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E462-8.
2000: MG Hollidge-Horvat; Michelle L Parolin; D Wong; Norman L Jones; George J F Heigenhauser
Effect of induced metabolic alkalosis on human skeletal muscle metabolism during exercise.
American journal of physiology. Endocrinology and metabolism 2000;278(2):E316-29.
2000: Michael Lindinger; T W Franklin; Larry Lands; P K Pedersen; Donald G Welsh; George J F Heigenhauser
NaHCO(3) and KHCO(3) ingestion rapidly increases renal electrolyte excretion in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(2):540-50.
2000: M C Riddell; Oded Bar-Or; H C Gerstein; George J F Heigenhauser
Perceived exertion with glucose ingestion in adolescent males with IDDM.
Medicine and science in sports and exercise 2000;32(1):167-73.
1999: Michelle L Parolin; A Chesley; MP Matsos; Lawrence L Spriet; Norman L Jones; George J F Heigenhauser
Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise.
The American journal of physiology 1999;277(5 Pt 1):E890-900.
1999: RA Howlett; George J F Heigenhauser; Lawrence L Spriet
Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(5):1747-51.
1999: MG Hollidge-Horvat; Michelle L Parolin; D Wong; Norman L Jones; George J F Heigenhauser
Effect of induced metabolic acidosis on human skeletal muscle metabolism during exercise.
The American journal of physiology 1999;277(4 Pt 1):E647-58.
1999: H R Stampfli; S Misiaszek; J H Lumsden; G P Carlson; George J F Heigenhauser
Weak acid-concentration Atot and dissociation constant Ka of plasma proteins in racehorses.
Equine veterinary journal. Supplement 1999;(30):438-42.
1999: RA Howlett; George J F Heigenhauser; E Hultman; MG Hollidge-Horvat; Lawrence L Spriet
Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise.
The American journal of physiology 1999;277(1 Pt 1):E18-25.
1999: CT Putman; MP Matsos; E Hultman; Norman L Jones; George J F Heigenhauser
Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men.
The American journal of physiology 1999;276(3 Pt 1):E483-8.
1999: George J F Heigenhauser; Michelle L Parolin
Role of pyruvate dehydrogenase in lactate production in exercising human skeletal muscle.
Advances in experimental medicine and biology 1999;474():205-18.
1999: Michael Lindinger; T W Franklin; Larry Lands; P K Pedersen; Donald G Welsh; George J F Heigenhauser
Role of skeletal muscle in plasma ion and acid-base regulation after NaHCO3 and KHCO3 loading in humans.
The American journal of physiology 1999;276(1 Pt 2):R32-43.
1998: Sandra J Peters; TA St Amand; RA Howlett; George J F Heigenhauser; Lawrence L Spriet
Human skeletal muscle pyruvate dehydrogenase kinase activity increases after a low-carbohydrate diet.
The American journal of physiology 1998;275(6 Pt 1):E980-6.
1998: A Chesley; RA Howlett; George J F Heigenhauser; E Hultman; Lawrence L Spriet
Regulation of muscle glycogenolytic flux during intense aerobic exercise after caffeine ingestion.
The American journal of physiology 1998;275(2 Pt 2):R596-603.
1998: RA Howlett; Michelle L Parolin; David J Dyck; E Hultman; Norman L Jones; George J F Heigenhauser; Lawrence L Spriet
Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs.
The American journal of physiology 1998;275(2 Pt 2):R418-25.
1998: CT Putman; Norman L Jones; E Hultman; MG Hollidge-Horvat; Arend Bonen; D R McConachie; George J F Heigenhauser
Effects of short-term submaximal training in humans on muscle metabolism in exercise.
The American journal of physiology 1998;275(1 Pt 1):E132-9.
1998: P M Berthon; RA Howlett; George J F Heigenhauser; Lawrence L Spriet
Human skeletal muscle carnitine palmitoyltransferase I activity determined in isolated intact mitochondria.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(1):148-53.
1998: LM Odland; RA Howlett; George J F Heigenhauser; E Hultman; Lawrence L Spriet
Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans.
The American journal of physiology 1998;274(6 Pt 1):E1080-5.
1998: LM Odland; George J F Heigenhauser; D Wong; MG Hollidge-Horvat; Lawrence L Spriet
Effects of increased fat availability on fat-carbohydrate interaction during prolonged exercise in men.
The American journal of physiology 1998;274(4 Pt 2):R894-902.
1998: Arend Bonen; K J McCullagh; CT Putman; E Hultman; Norman L Jones; George J F Heigenhauser
Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate.
The American journal of physiology 1998;274(1 Pt 1):E102-7.
1997: E R Chin; Michael Lindinger; George J F Heigenhauser
Distribution of lactate and other ions in inactive skeletal muscle: influence of hyperkalemic lactacidosis.
Canadian journal of physiology and pharmacology 1997;75(12):1375-86.
1997: Michael J McKenna; George J F Heigenhauser; Robert S McKelvie; George Obminski; JD MacDougall; Norman L Jones
Enhanced pulmonary and active skeletal muscle gas exchange during intense exercise after sprint training in men.
The Journal of physiology 1997;501 ( Pt 3)():703-16.
1997: Michael J McKenna; George J F Heigenhauser; Robert S McKelvie; JD MacDougall; Norman L Jones
Sprint training enhances ionic regulation during intense exercise in men.
The Journal of physiology 1997;501 ( Pt 3)():687-702.
1997: Y Wang; P M Wright; George J F Heigenhauser; Chris M Wood
Lactate transport by rainbow trout white muscle: kinetic characteristics and sensitivity to inhibitors.
The American journal of physiology 1997;272(5 Pt 2):R1577-87.
1996: Y Wang; George J F Heigenhauser; Chris M Wood
Lactate and metabolic H+ transport and distribution after exercise in rainbow trout white muscle.
The American journal of physiology 1996;271(5 Pt 2):R1239-50.
1996: P S Wendling; Sandra J Peters; George J F Heigenhauser; Lawrence L Spriet
Variability of triacylglycerol content in human skeletal muscle biopsy samples.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;81(3):1150-5.
1996: Y Wang; George J F Heigenhauser; Chris M Wood
Ammonia movement and distribution after exercise across white muscle cell membranes in rainbow trout.
The American journal of physiology 1996;271(3 Pt 2):R738-50.
1996: P S Wendling; Sandra J Peters; George J F Heigenhauser; Lawrence L Spriet
Epinephrine infusion does not enhance net muscle glycogenolysis during prolonged aerobic exercise.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée 1996;21(4):271-84.
1996: M E Trump; George J F Heigenhauser; C T Putman; Lawrence L Spriet
Importance of muscle phosphocreatine during intermittent maximal cycling.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;80(5):1574-80.
1996: L M Odland; George J F Heigenhauser; G D Lopaschuk; Lawrence L Spriet
Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise.
The American journal of physiology 1996;270(3 Pt 1):E541-4.
1996: S O Turner-Gomes; Larry Lands; Jacqueline Halton; R M Hanning; George J F Heigenhauser; M Pai; R Barr
Cardiorespiratory status after treatment for acute lymphoblastic leukemia.
Medical and pediatric oncology 1996;26(3):160-5.
1996: A Chesley; George J F Heigenhauser; Lawrence L Spriet
Regulation of muscle glycogen phosphorylase activity following short-term endurance training.
The American journal of physiology 1996;270(2 Pt 1):E328-35.
1996: Stuart M Phillips; Howard J Green; Mark A Tarnopolsky; George J F Heigenhauser; SM Grant
Progressive effect of endurance training on metabolic adaptations in working skeletal muscle.
The American journal of physiology 1996;270(2 Pt 1):E265-72.
1996: Helge Hebestreit; F Meyer; George J F Heigenhauser; Oded Bar-Or
Plasma metabolites, volume and electrolytes following 30-s high-intensity exercise in boys and men.
European journal of applied physiology and occupational physiology 1996;72(5-6):563-9.
1995: George J F Heigenhauser
A quantitative approach to acid-base chemistry.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée 1995;20(3):333-40.
1995: C T Putman; Norman L Jones; Larry Lands; T M Bragg; MG Hollidge-Horvat; George J F Heigenhauser
Skeletal muscle pyruvate dehydrogenase activity during maximal exercise in humans.
The American journal of physiology 1995;269(3 Pt 1):E458-68.
1995: C T Putman; Lawrence L Spriet; E Hultman; David J Dyck; George J F Heigenhauser
Skeletal muscle pyruvate dehydrogenase activity during acetate infusion in humans.
The American journal of physiology 1995;268(5 Pt 1):E1007-17.
1995: Michael Lindinger; Robert S McKelvie; George J F Heigenhauser
K+ and Lac- distribution in humans during and after high-intensity exercise: role in muscle fatigue attenuation?
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(3):765-77.
1994: Y Wang; George J F Heigenhauser; Chris M Wood
Integrated responses to exhaustive exercise and recovery in rainbow trout white muscle: acid-base, phosphogen, carbohydrate, lipid, ammonia, fluid volume and electrolyte metabolism.
The Journal of experimental biology 1994;195():227-58.
1994: Michael Lindinger; Lawrence L Spriet; E Hultman; T Putman; Robert S McKelvie; Larry Lands; Norman L Jones; George J F Heigenhauser
Plasma volume and ion regulation during exercise after low- and high-carbohydrate diets.
The American journal of physiology 1994;266(6 Pt 2):R1896-906.
1993: David J Dyck; C T Putman; George J F Heigenhauser; E Hultman; Lawrence L Spriet
Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling.
The American journal of physiology 1993;265(6 Pt 1):E852-9.
1993: C T Putman; Lawrence L Spriet; E Hultman; Michael Lindinger; Larry Lands; Robert S McKelvie; G Cederblad; Norman L Jones; George J F Heigenhauser
Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets.
The American journal of physiology 1993;265(5 Pt 1):E752-60.
1993: Larry Lands; C Gordon; Oded Bar-Or; Cameron J R Blimkie; R M Hanning; Norman L Jones; L A Moss; Colin E Webber; W M Wilson; George J F Heigenhauser
Comparison of three techniques for body composition analysis in cystic fibrosis.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(1):162-6.
1993: Larry Lands; George J F Heigenhauser; Norman L Jones
Respiratory and peripheral muscle function in cystic fibrosis.
The American review of respiratory disease 1993;147(4):865-9.
1993: Larry Lands; George J F Heigenhauser; Norman L Jones
Maximal short-term exercise performance and ion regulation in cystic fibrosis.
Canadian journal of physiology and pharmacology 1993;71(1):12-6.
1993: CL Gordon; Colin E Webber; George J F Heigenhauser
The accuracy of dual photon measurements of soft tissue composition.
Basic life sciences 1993;60():333-5.
1992: Larry Lands; George J F Heigenhauser; Norman L Jones
Cardiac output determination during progressive exercise in cystic fibrosis.
Chest 1992;102(4):1118-23.
1992: Larry Lands; George J F Heigenhauser; Norman L Jones
Analysis of factors limiting maximal exercise performance in cystic fibrosis.
Clinical science (London, England : 1979) 1992;83(4):391-7.
1992: M Scarabello; George J F Heigenhauser; Chris M Wood
Gas exchange, metabolite status and excess post-exercise oxygen consumption after repetitive bouts of exhaustive exercise in juvenile rainbow trout.
The Journal of experimental biology 1992;167():155-69.
1992: Michael Lindinger; George J F Heigenhauser; Robert S McKelvie; Norman L Jones
Blood ion regulation during repeated maximal exercise and recovery in humans.
The American journal of physiology 1992;262(1 Pt 2):R126-36.
1992: J M Kowalchuk; George J F Heigenhauser; JR Sutton; Norman L Jones
Effect of acetazolamide on gas exchange and acid-base control after maximal exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(1):278-87.
1991: Larry Lands; George J F Heigenhauser; C Gordon; Norman L Jones; Colin E Webber
Accuracy of measurements of small changes in soft tissue mass by use of dual-photon absorptiometry.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(2):698-702.
1991: Robert S McKelvie; Michael Lindinger; George J F Heigenhauser; Norman L Jones
Contribution of erythrocytes to the control of the electrolyte changes of exercise.
Canadian journal of physiology and pharmacology 1991;69(7):984-93.
1991: E R Chin; Michael Lindinger; George J F Heigenhauser
Lactate metabolism in inactive skeletal muscle during lactacidosis.
The American journal of physiology 1991;261(1 Pt 2):R98-105.
1991: M Scarabello; George J F Heigenhauser; Chris M Wood
The oxygen debt hypothesis in juvenile rainbow trout after exhaustive exercise.
Respiration physiology 1991;84(2):245-59.
1991: Michael Lindinger; George J F Heigenhauser
The roles of ion fluxes in skeletal muscle fatigue.
Canadian journal of physiology and pharmacology 1991;69(2):246-53.
1991: Robert S McKelvie; Norman L Jones; George J F Heigenhauser
Factors contributing to increased muscle fatigue with beta-blockers.
Canadian journal of physiology and pharmacology 1991;69(2):254-61.
1990: L Makrides; George J F Heigenhauser; Norman L Jones
High-intensity endurance training in 20- to 30- and 60- to 70-yr-old healthy men.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(5):1792-8.
1990: Michael Lindinger; George J F Heigenhauser; Lawrence L Spriet
Effects of alkalosis on muscle ions at rest and with intense exercise.
Canadian journal of physiology and pharmacology 1990;68(7):820-9.
1990: Michael Lindinger; George J F Heigenhauser; Robert S McKelvie; Norman L Jones
Role of nonworking muscle on blood metabolites and ions with intense intermittent exercise.
The American journal of physiology 1990;258(6 Pt 2):R1486-94.
1989: Robert S McKelvie; Michael Lindinger; George J F Heigenhauser; JR Sutton; Norman L Jones
Renal responses to exercise-induced lactic acidosis.
The American journal of physiology 1989;257(1 Pt 2):R102-8.
1989: Lawrence L Spriet; Michael Lindinger; Robert S McKelvie; George J F Heigenhauser; Norman L Jones
Muscle glycogenolysis and H+ concentration during maximal intermittent cycling.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(1):8-13.
1988: J M Kowalchuk; George J F Heigenhauser; Michael Lindinger; G Obminski; JR Sutton; Norman L Jones
Role of lungs and inactive muscle in acid-base control after maximal exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(5):2090-6.
1988: J M Kowalchuk; George J F Heigenhauser; Michael Lindinger; JR Sutton; Norman L Jones
Factors influencing hydrogen ion concentration in muscle after intense exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(5):2080-9.
1988: George J F Heigenhauser; Michael Lindinger
The total ionic status of muscle during intense exercise.
Advances in experimental medicine and biology 1988;227():237-42.
1988: Michael Lindinger; George J F Heigenhauser
Ion fluxes during tetanic stimulation in isolated perfused rat hindlimb.
The American journal of physiology 1988;254(1 Pt 2):R117-26.
1987: Michael Lindinger; George J F Heigenhauser; Lawrence L Spriet
Effects of intense swimming and tetanic electrical stimulation on skeletal muscle ions and metabolites.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(6):2331-9.
1987: Robert S McKelvie; George J F Heigenhauser; Norman L Jones
Measurement of cardiac output by CO2 rebreathing in unsteady state exercise.
Chest 1987;92(5):777-82.
1985: L Makrides; George J F Heigenhauser; Neil McCartney; Norman L Jones
Maximal short term exercise capacity in healthy subjects aged 15-70 years.
Clinical science (London, England : 1979) 1985;69(2):197-205.
1985: Lawrence L Spriet; Sandra J Peters; George J F Heigenhauser; N L Jones
Rat skeletal muscle triacylglycerol utilization during exhaustive swimming.
Canadian journal of physiology and pharmacology 1985;63(6):614-8.
1985: Neil McCartney; G Obminski; George J F Heigenhauser
Torque-velocity relationship in isokinetic cycling exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;58(5):1459-62.
1985: Lawrence L Spriet; C G Matsos; Sandra J Peters; George J F Heigenhauser; N L Jones
Effects of acidosis on rat muscle metabolism and performance during heavy exercise.
The American journal of physiology 1985;248(3 Pt 1):C337-47.
1985: Lawrence L Spriet; C G Matsos; Sandra J Peters; George J F Heigenhauser; N L Jones
Muscle metabolism and performance in perfused rat hindquarter during heavy exercise.
The American journal of physiology 1985;248(1 Pt 1):C109-18.
1980: N L Jones; George J F Heigenhauser; A Kuksis; C G Matsos; J R Sutton; C J Toews
Fat metabolism in heavy exercise.
Clinical science (London, England : 1979) 1980;59(6):469-78.