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Joseph Heijnen

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Hilal Taymaz-Nikerel; Gino Baart; Marjan De Mey; Joseph J Heijnen; Jo Maertens; Walter M van Gulik
Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses.
A L B Cruz; L J Geurink; Joseph J Heijnen; A J Verbon; Peter Verheijen; Walter M van Gulik
Use of sequential-batch fermentations to characterize the impact of mild hypothermic temperatures on the anaerobic stoichiometry and kinetics of Saccharomyces cerevisiae.
Rutger D Douma; Joseph J Heijnen; Reza M Seifar; Bouke W de Jong; Lodewijk P de Jonge; Amit Deshmukh; Walter M van Gulik
Novel insights in transport mechanisms and kinetics of phenylacetic acid and penicillin-G in Penicillium chrysogenum.

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All Publications

2013: Hilal Taymaz-Nikerel; Gino Baart; Marjan De Mey; Joseph J Heijnen; Jo Maertens; Walter M van Gulik
Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses.
Metabolic engineering 2013;16():115-29.
2012: A L B Cruz; L J Geurink; Joseph J Heijnen; A J Verbon; Peter Verheijen; Walter M van Gulik
Use of sequential-batch fermentations to characterize the impact of mild hypothermic temperatures on the anaerobic stoichiometry and kinetics of Saccharomyces cerevisiae.
Biotechnology and bioengineering 2012;109(7):1735-44.
2012: Rutger D Douma; Joseph J Heijnen; Reza M Seifar; Bouke W de Jong; Lodewijk P de Jonge; Amit Deshmukh; Walter M van Gulik
Novel insights in transport mechanisms and kinetics of phenylacetic acid and penicillin-G in Penicillium chrysogenum.
Biotechnology progress 2012;28(2):337-48.
2012: Luisa Ana B Cruz; Pascale Daran-Lapujade; Giang-Huong Duong; Marit Hebly; Joseph J Heijnen; Jack T Pronk; Sebastian A Wahl; Walter M van Gulik
Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics?
BMC systems biology 2012;6():151.
2012: Zheng Zhao; Lodewijk de Jonge; Joseph J Heijnen; Angela Ten Pierick; S Aljoscha Wahl
Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis.
Microbial cell factories 2012;11():140.
2012: Walter M van Gulik; Hilal Taymaz-Nikerel; Andre B Canelas; Lodewijk P de Jonge; Rutger D Douma; Joseph J Heijnen
Fast sampling of the cellular metabolome.
Methods in molecular biology (Clifton, N.J.) 2012;881():279-306.
2011: Lodewijk P de Jonge; Amit Deshmukh; Joseph J Heijnen; Jan A K W Kiel; Angela ten Pierick; Nicolaas A A Buijs; Zheng Zhao; Walter M van Gulik
Scale-down of penicillin production in Penicillium chrysogenum.
Biotechnology journal 2011;6(8):944-58.
2011: Hilal Taymaz-Nikerel; Walter M van Gulik; Joseph J Heijnen
Escherichia coli responds with a rapid and large change in growth rate upon a shift from glucose-limited to glucose-excess conditions.
Metabolic engineering 2011;13(3):307-18.
2011: André B Canelas; Cor Ras; Angela ten Pierick; Walter M van Gulik; Joseph J Heijnen
An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data.
Metabolic engineering 2011;13(3):294-306.
2011: Sergio Rossell; Christian Solem; Peter R Jensen; Joseph J Heijnen
Towards a quantitative prediction of the fluxome from the proteome.
Metabolic engineering 2011;13(3):253-62.
2011: Rutger D Douma; Joseph J Heijnen; Jan A K W Kiel; Paul Klaassen; Arjen M Krikken; Kai M Touw; Joana M Batista; Roel A L Bovenberg; Jean-Marc Daran; Tânia Veiga; Zheng Zhao; Walter M van Gulik
Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach.
BMC systems biology 2011;5():132.
2011: Hendrik Waegeman; Joeri Beauprez; Helena Moens; Jo Maertens; Marjan De Mey; Maria R Foulquié-Moreno; Joseph J Heijnen; Daniel Charlier; Wim Soetaert
Effect of iclR and arcA knockouts on biomass formation and metabolic fluxes in Escherichia coli K12 and its implications on understanding the metabolism of Escherichia coli BL21 (DE3).
BMC microbiology 2011;11():70.
2011: Zheng Zhao; Karel Kuijvenhoven; Walter M van Gulik; Joseph J Heijnen; Wouter A van Winden; Peter Verheijen
Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol.
Applied microbiology and biotechnology 2011;89(1):63-72.
2010: H Wouter Wisselink; Chiara Cipollina; Bart Oud; Barbara Crimi; Joseph J Heijnen; Jack T. Pronk; Antonius J A van Maris
Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae.
Metabolic engineering 2010;12(6):537-51.
2010: Hilal Taymaz-Nikerel; Amin Espah Borujeni; Peter Verheijen; Joseph J Heijnen; Walter M van Gulik
Genome-derived minimal metabolic models for Escherichia coli MG1655 with estimated in vivo respiratory ATP stoichiometry.
Biotechnology and bioengineering 2010;107(2):369-81.
2010: Rutger D Douma; Lodewijk P de Jonge; Caspar T H Jonker; Reza M Seifar; Joseph J Heijnen; Walter M van Gulik
Intracellular metabolite determination in the presence of extracellular abundance: Application to the penicillin biosynthesis pathway in Penicillium chrysogenum.
Biotechnology and bioengineering 2010;107(1):105-15.
2010: Marjan De Mey; Hilal Taymaz-Nikerel; Gino Baart; Hendrik Waegeman; Jo Maertens; Joseph J Heijnen; Walter M van Gulik
Catching prompt metabolite dynamics in Escherichia coli with the BioScope at oxygen rich conditions.
Metabolic engineering 2010;12(5):477-87.
2010: Rutger D Douma; Peter Verheijen; Wim T A M de Laat; Joseph J Heijnen; Walter M van Gulik
Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum.
Biotechnology and bioengineering 2010;106(4):608-18.
2010: Joseph J Heijnen
Impact of thermodynamic principles in systems biology.
Advances in biochemical engineering/biotechnology 2010;121():139-62.
2010: Michiel van Leeuwen; Erik E Krommenhoek; Joseph J Heijnen; Han Gardeniers; Luuk A M van der Wielen; Walter M van Gulik
Aerobic batch cultivation in micro bioreactor with integrated electrochemical sensor array.
Biotechnology progress 2010;26(1):293-300.
2009: Alvaro R Lara; Hilal Taymaz-Nikerel; Mlawule R Mashego; Walter M van Gulik; Joseph J Heijnen; Octavio T Ramírez; Wouter A van Winden
Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses.
Biotechnology and bioengineering 2009;104(6):1153-61.
2009: Michiel van Leeuwen; Xiaonan Li; Erik E Krommenhoek; Han Gardeniers; Marcel Ottens; Luuk A M van der Wielen; Joseph J Heijnen; Walter M van Gulik
Quantitative determination of glucose transfer between concurrent laminar water streams in a H-shaped microchannel.
Biotechnology progress 2009;25(6):1826-32.
2009: Chiara Cipollina; Angela ten Pierick; André B Canelas; Reza M Seifar; Antonius J A van Maris; Jan C van Dam; Joseph J Heijnen
A comprehensive method for the quantification of the non-oxidative pentose phosphate pathway intermediates in Saccharomyces cerevisiae by GC-IDMS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(27):3231-6.
2009: André B Canelas; Angela ten Pierick; Cor Ras; Reza M Seifar; Jan C van Dam; Walter M van Gulik; Joseph J Heijnen
Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics.
Analytical chemistry 2009;81(17):7379-89.
2009: Reza M Seifar; Cor Ras; Jan C van Dam; Walter M van Gulik; Joseph J Heijnen; Wouter A van Winden
Simultaneous quantification of free nucleotides in complex biological samples using ion pair reversed phase liquid chromatography isotope dilution tandem mass spectrometry.
Analytical biochemistry 2009;388(2):213-9.
2009: Michiel van Leeuwen; Joseph J Heijnen; Han Gardeniers; Luuk A M van der Wielen; Walter M van Gulik
Development of a system for the on-line measurement of carbon dioxide production in microbioreactors: application to aerobic batch cultivations of Candida utilis.
Biotechnology progress 2009;25(3):892-7.
2009: Fredrick O Aboka; Joseph J Heijnen; Wouter A van Winden
Dynamic 13C-tracer study of storage carbohydrate pools in aerobic glucose-limited Saccharomyces cerevisiae confirms a rapid steady-state turnover and fast mobilization during a modest stepup in the glucose uptake rate.
FEMS yeast research 2009;9(2):191-201.
2009: Hilal Taymaz-Nikerel; Marjan De Mey; Cor Ras; Angela ten Pierick; Reza M Seifar; Jan C van Dam; Joseph J Heijnen; Walter M van Gulik
Development and application of a differential method for reliable metabolome analysis in Escherichia coli.
Analytical biochemistry 2009;386(1):9-19.
2009: Emrah Nikerel; Wouter A van Winden; Peter Verheijen; Joseph J Heijnen
Model reduction and a priori kinetic parameter identifiability analysis using metabolome time series for metabolic reaction networks with linlog kinetics.
Metabolic engineering 2009;11(1):20-30.
2008: M T A P Kresnowati; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Energetic and metabolic transient response of Saccharomyces cerevisiae to benzoic acid.
The FEBS journal 2008;275(22):5527-41.
2008: Joost van den Brink; André B Canelas; Walter M van Gulik; Jack T. Pronk; Joseph J Heijnen; Johannes H De Winde; Pascale Daran-Lapujade
Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism.
Applied and environmental microbiology 2008;74(18):5710-23.
2008: André B Canelas; Walter M van Gulik; Joseph J Heijnen
Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady-state and highly dynamic conditions.
Biotechnology and bioengineering 2008;100(4):734-43.
2008: Zheng Zhao; Karel Kuijvenhoven; Cor Ras; Walter M van Gulik; Joseph J Heijnen; Peter Verheijen; Wouter A van Winden
Isotopic non-stationary 13C gluconate tracer method for accurate determination of the pentose phosphate pathway split-ratio in Penicillium chrysogenum.
Metabolic engineering 2008;10(3-4):178-86.
2008: Reza M Seifar; Zheng Zhao; Jan van Dam; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Quantitative analysis of metabolites in complex biological samples using ion-pair reversed-phase liquid chromatography-isotope dilution tandem mass spectrometry.
Journal of chromatography. A 2008;1187(1-2):103-10.
2008: Erik E Krommenhoek; Michiel van Leeuwen; Han Gardeniers; Walter M van Gulik; Albert van den Berg; Xiaonan Li; Marcel Ottens; Luuk A M van der Wielen; Joseph J Heijnen
Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration.
Biotechnology and bioengineering 2008;99(4):884-92.
2008: M T A P Kresnowati; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Dynamic in vivo metabolome response of Saccharomyces cerevisiae to a stepwise perturbation of the ATP requirement for benzoate export.
Biotechnology and bioengineering 2008;99(2):421-41.
2008: M T A P Kresnowati; C M Suarez-Mendez; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Quantitative physiological study of the fast dynamics in the intracellular pH of Saccharomyces cerevisiae in response to glucose and ethanol pulses.
Metabolic engineering 2008;10(1):39-54.
2008: Uly Nasution; Walter M van Gulik; Cor Ras; Angela M Proell; Joseph J Heijnen
A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum.
Metabolic engineering 2008;10(1):10-23.
2007: E E Krommenhoek; J G E Gardeniers; Johan Bomer; X Li; Marcel Ottens; Gijs W K van Dedem; M Van Leeuwen; Walter M van Gulik; Luuk A M van der Wielen; Joseph J Heijnen; And A van den Berg
Integrated electrochemical sensor array for on-line monitoring of yeast fermentations.
Analytical chemistry 2007;79(15):5567-73.
2007: Roeland Costenoble; Dirk Mueller; Timo Barl; Walter M van Gulik; Wouter A van Winden; Matthias Reuss; Joseph J Heijnen
13C-Labeled metabolic flux analysis of a fed-batch culture of elutriated Saccharomyces cerevisiae.
FEMS yeast research 2007;7(4):511-26.
2007: M T A P Kresnowati; C Suarez-Mendez; M K Groothuizen; Wouter A van Winden; Joseph J Heijnen
Measurement of fast dynamic intracellular pH in Saccharomyces cerevisiae using benzoic acid pulse.
Biotechnology and bioengineering 2007;97(1):86-98.
2007: Roelco J Kleijn; Jan-Maarten A Geertman; Beckley K Nfor; Cor Ras; Dick Schipper; Jack T. Pronk; Joseph J Heijnen; Antonius J A van Maris; Wouter A van Winden
Metabolic flux analysis of a glycerol-overproducing Saccharomyces cerevisiae strain based on GC-MS, LC-MS and NMR-derived C-labelling data.
FEMS yeast research 2007;7(2):216-31.
2007: Mlawule R Mashego; Walter M van Gulik; Joseph J Heijnen
Metabolome dynamic responses of Saccharomyces cerevisiae to simultaneous rapid perturbations in external electron acceptor and electron donor.
FEMS yeast research 2007;7(1):48-66.
2007: Mlawule R Mashego; Karl Rumbold; Marjan De Mey; Erick J Vandamme; Wim Soetaert; Joseph J Heijnen
Microbial metabolomics: past, present and future methodologies.
Biotechnology letters 2007;29(1):1-16.
2007: Roelco J Kleijn; Feng Liu; Wouter A van Winden; Walter M van Gulik; Cor Ras; Joseph J Heijnen
Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum.
Metabolic engineering 2007;9(1):112-23.
2006: Fredrick O Aboka; Huiling Yang; Lodewijk P de Jonge; Rob Kerste; Wouter A van Winden; Walter M van Gulik; Rob Hoogendijk; Arthur Oudshoorn; Joseph J Heijnen
Characterization of an experimental miniature bioreactor for cellular perturbation studies.
Biotechnology and bioengineering 2006;95(6):1032-42.
2006: Uly Nasution; Walter M van Gulik; Angela M Proell; Wouter A van Winden; Joseph J Heijnen
Generating short-term kinetic responses of primary metabolism of Penicillium chrysogenum through glucose perturbation in the bioscope mini reactor.
Metabolic engineering 2006;8(5):395-405.
2006: Gilles P van Wezel; Preben Krabben; Bjørn A Traag; Bart J F Keijser; Rob Kerste; Erik Vijgenboom; Joseph J Heijnen; Barend Kraal
Unlocking Streptomyces spp. for use as sustainable industrial production platforms by morphological engineering.
Applied and environmental microbiology 2006;72(8):5283-8.
2006: Roelco J Kleijn; Wouter A van Winden; Cor Ras; Walter M van Gulik; Dick Schipper; Joseph J Heijnen
13C-labeled gluconate tracing as a direct and accurate method for determining the pentose phosphate pathway split ratio in Penicillium chrysogenum.
Applied and environmental microbiology 2006;72(7):4743-54.
2006: Mlawule R Mashego; Walter M van Gulik; Jacobus L Vinke; Diana Visser; Joseph J Heijnen
In vivo kinetics with rapid perturbation experiments in Saccharomyces cerevisiae using a second-generation BioScope.
Metabolic engineering 2006;8(4):370-83.
2006: Evelyn M Buque-Taboada; Adrie J J Straathof; Joseph J Heijnen; Luuk A M van der Wielen
In situ product recovery (ISPR) by crystallization: basic principles, design, and potential applications in whole-cell biocatalysis.
Applied microbiology and biotechnology 2006;71(1):1-12.
2006: Uly Nasution; Walter M van Gulik; Roelco J Kleijn; Wouter A van Winden; Angela M Proell; Joseph J Heijnen
Measurement of intracellular metabolites of primary metabolism and adenine nucleotides in chemostat cultivated Penicillium chrysogenum.
Biotechnology and bioengineering 2006;94(1):159-66.
2006: Liang Wu; Jan van Dam; Dick Schipper; M T A P Kresnowati; Angela M Proell; Cor Ras; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Short-term metabolome dynamics and carbon, electron, and ATP balances in chemostat-grown Saccharomyces cerevisiae CEN.PK 113-7D following a glucose pulse.
Applied and environmental microbiology 2006;72(5):3566-77.
2006: Liang Wu; Mlawule R Mashego; Angela M Proell; Jacobus L Vinke; Cor Ras; Jan van Dam; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
In vivo kinetics of primary metabolism in Saccharomyces cerevisiae studied through prolonged chemostat cultivation.
Metabolic engineering 2006;8(2):160-71.
2006: Sirous Ebrahimi; Robbert Kleerebezem; M T Kreutzer; Freek Kapteijn; Jacob A Moulijn; Joseph J Heijnen; Mark van loosdrecht
Potential application of monolith packed columns as bioreactors, control of biofilm formation.
Biotechnology and bioengineering 2006;93(2):238-45.
2006: Emrah Nikerel; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
A method for estimation of elasticities in metabolic networks using steady state and dynamic metabolomics data and linlog kinetics.
BMC bioinformatics 2006;7():540.
2006: M T A P Kresnowati; Wouter A van Winden; Marinka J H Almering; A ten Pierick; Cor Ras; Theo A Knijnenburg; Pascale Daran-Lapujade; Jack T. Pronk; Joseph J Heijnen; Jean-Marc Daran
When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation.
Molecular systems biology 2006;2():49.
2005: Roelco J Kleijn; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence.
The FEBS journal 2005;272(19):4970-82.
2005: Joseph J Heijnen
Approximative kinetic formats used in metabolic network modeling.
Biotechnology and bioengineering 2005;91(5):534-45.
2005: Liang Wu; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Application of metabolome data in functional genomics: a conceptual strategy.
Metabolic engineering 2005;7(4):302-10.
2005: Anuska Mosquera-Corral; Merle K De Kreuk; Joseph J Heijnen; Mark van loosdrecht
Effects of oxygen concentration on N-removal in an aerobic granular sludge reactor.
Water research 2005;39(12):2676-86.
2005: Merle K De Kreuk; Joseph J Heijnen; Mark van loosdrecht
Simultaneous COD, nitrogen, and phosphate removal by aerobic granular sludge.
Biotechnology and bioengineering 2005;90(6):761-9.
2005: S Ebrahimi; F J Fernández Morales; Robbert Kleerebezem; Joseph J Heijnen; Mark van loosdrecht
High-rate acidophilic ferrous iron oxidation in a biofilm airlift reactor and the role of the carrier material.
Biotechnology and bioengineering 2005;90(4):462-72.
2005: Wouter A van Winden; Jan C van Dam; Cor Ras; Roelco J Kleijn; Jacobus L Vinke; Walter M van Gulik; Joseph J Heijnen
Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites.
FEMS yeast research 2005;5(6-7):559-68.
2005: Christoph Wittmann; Michael Hans; Wouter A van Winden; Cor Ras; Joseph J Heijnen
Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae.
Biotechnology and bioengineering 2005;89(7):839-47.
2005: M T A P Kresnowati; Wouter A van Winden; Joseph J Heijnen
Determination of elasticities, concentration and flux control coefficients from transient metabolite data using linlog kinetics.
Metabolic engineering 2005;7(2):142-53.
2005: Mlawule R Mashego; Mickel L A Jansen; Jacobus L Vinke; Walter M van Gulik; Joseph J Heijnen
Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic glucose-limited chemostats.
FEMS yeast research 2005;5(4-5):419-30.
2005: Liang Wu; Mlawule R Mashego; Jan C van Dam; Angela M Proell; Jacobus L Vinke; Cor Ras; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards.
Analytical biochemistry 2005;336(2):164-71.
2004: António M P Martins; Cristian Picioreanu; Joseph J Heijnen; Mark van loosdrecht
Three-dimensional dual-morphotype species modeling of activated sludge flocs.
Environmental science & technology 2004;38(21):5632-41.
2004: Diana Visser; Gertan A van Zuylen; Jan C van Dam; Michael R Eman; Angela Pröll; Cor Ras; Liang Wu; Walter M van Gulik; Joseph J Heijnen
Analysis of in vivo kinetics of glycolysis in aerobic Saccharomyces cerevisiae by application of glucose and ethanol pulses.
Biotechnology and bioengineering 2004;88(2):157-67.
2004: Joseph J Heijnen; Walter M van Gulik; H Shimizu; G Stephanopoulos
Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data.
Metabolic engineering 2004;6(4):391-400.
2004: Diana Visser; Joachim W Schmid; Klaus Mauch; Matthias Reuss; Joseph J Heijnen
Optimal re-design of primary metabolism in Escherichia coli using linlog kinetics.
Metabolic engineering 2004;6(4):378-90.
2004: Liang Wu; Weiming Wang; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
A new framework for the estimation of control parameters in metabolic pathways using lin-log kinetics.
European journal of biochemistry / FEBS 2004;271(16):3348-59.
2004: Evelyn M Buque-Taboada; Adrie J J Straathof; Joseph J Heijnen; Luuk A M van der Wielen
In situ product removal using a crystallization loop in asymmetric reduction of 4-oxoisophorone by Saccharomyces cerevisiae.
Biotechnology and bioengineering 2004;86(7):795-800.
2004: António M P Martins; Joseph J Heijnen; Mark van loosdrecht
Bulking sludge in biological nutrient removal systems.
Biotechnology and bioengineering 2004;86(2):125-35.
2004: Mlawule R Mashego; Liang Wu; Jan C van Dam; Cor Ras; Jacobus L Vinke; Wouter A van Winden; Walter M van Gulik; Joseph J Heijnen
MIRACLE: mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites.
Biotechnology and bioengineering 2004;85(6):620-8.
2004: António M P Martins; Krishna R Pagilla; Joseph J Heijnen; Mark van loosdrecht
Filamentous bulking sludge--a critical review.
Water research 2004;38(4):793-817.
2003: António M P Martins; Joseph J Heijnen; Mark van loosdrecht
Effect of dissolved oxygen concentration on sludge settleability.
Applied microbiology and biotechnology 2003;62(5-6):586-93.
2003: Mlawule R Mashego; Walter M van Gulik; Jacobus L Vinke; Joseph J Heijnen
Critical evaluation of sampling techniques for residual glucose determination in carbon-limited chemostat culture of Saccharomyces cerevisiae.
Biotechnology and bioengineering 2003;83(4):395-9.
2003: Wouter A van Winden; Walter M van Gulik; Dick Schipper; Peter Verheijen; Preben Krabben; Jacobus L Vinke; Joseph J Heijnen
Metabolic flux and metabolic network analysis of Penicillium chrysogenum using 2D [13C, 1H] COSY NMR measurements and cumulative bondomer simulation.
Biotechnology and bioengineering 2003;83(1):75-92.
2003: Diana Visser; Joseph J Heijnen
Dynamic simulation and metabolic re-design of a branched pathway using linlog kinetics.
Metabolic engineering 2003;5(3):164-76.
2003: G Farabegoli; C Hellinga; Joseph J Heijnen; Mark van loosdrecht
Study on the use of NADH fluorescence measurements for monitoring wastewater treatment systems.
Water research 2003;37(11):2732-8.
2003: António M P Martins; Joseph J Heijnen; Mark van loosdrecht
Effect of feeding pattern and storage on the sludge settleability under aerobic conditions.
Water research 2003;37(11):2555-70.
2003: S Salem; D H J G Berends; Joseph J Heijnen; Mark van loosdrecht
Bio-augmentation by nitrification with return sludge.
Water research 2003;37(8):1794-804.
2003: Liang Wu; HC Lange; Walter M van Gulik; Joseph J Heijnen
Determination of in vivo oxygen uptake and carbon dioxide evolution rates from off-gas measurements under highly dynamic conditions.
Biotechnology and bioengineering 2003;81(4):448-58.
2003: Anuska Mosquera-Corral; A Montràs; Joseph J Heijnen; Mark van loosdrecht
Degradation of polymers in a biofilm airlift suspension reactor.
Water research 2003;37(3):485-92.
2002: Wouter A van Winden; Joseph J Heijnen; Peter Verheijen
Cumulative bondomers: a new concept in flux analysis from 2D [13C,1H] COSY NMR data.
Biotechnology and bioengineering 2002;80(7):731-45.
2002: Wouter A van Winden; Christoph Wittmann; Elmar Heinzle; Joseph J Heijnen
Correcting mass isotopomer distributions for naturally occurring isotopes.
Biotechnology and bioengineering 2002;80(4):477-9.
2002: Xiaodi Hao; Joseph J Heijnen; Mark van loosdrecht
Model-based evaluation of temperature and inflow variations on a partial nitrification-ANAMMOX biofilm process.
Water research 2002;36(19):4839-49.
2002: S C F Meijer; Mark van loosdrecht; Joseph J Heijnen
Modelling the start-up of a full-scale biological phosphorous and nitrogen removing WWTP.
Water research 2002;36(19):4667-82.
2002: Diana Visser; Gertan A van Zuylen; Jan C van Dam; Arthur Oudshoorn; Michael R Eman; Cor Ras; Walter M van Gulik; Johannes Frank; Gijs W K van Dedem; Joseph J Heijnen
Rapid sampling for analysis of in vivo kinetics using the BioScope: a system for continuous-pulse experiments.
Biotechnology and bioengineering 2002;79(6):674-81.
2002: W F Willeman; R Neuhofer; I Wirth; P Pöchlauer; Adrie J J Straathof; Joseph J Heijnen
Development of (R)-4-hydroxymandelonitrile synthesis in an aqueous-organic biphasic stirred tank batch reactor.
Biotechnology and bioengineering 2002;79(2):154-64.
2002: M B Diender; Adrie J J Straathof; T van der Does; Cor Ras; Joseph J Heijnen
Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization.
Biotechnology and bioengineering 2002;78(4):395-402.
2002: Hans Roubos; Preben Krabben; Wim T A M de Laat; Robert Babuska; Joseph J Heijnen
Clavulanic acid degradation in Streptomyces clavuligerus fed-batch cultivations.
Biotechnology progress 2002;18(3):451-7.
2002: Diana Visser; Joseph J Heijnen
The mathematics of metabolic control analysis revisited.
Metabolic engineering 2002;4(2):114-23.
2002: JJ Beun; K Dircks; Mark van loosdrecht; Joseph J Heijnen
Poly-beta-hydroxybutyrate metabolism in dynamically fed mixed microbial cultures.
Water research 2002;36(5):1167-80.
2002: Xiaodi Hao; Joseph J Heijnen; Mark van loosdrecht
Sensitivity analysis of a biofilm model describing a one-stage completely autotrophic nitrogen removal (CANON) process.
Biotechnology and bioengineering 2002;77(3):266-77.
2002: Wouter F Willeman; Pieter Jan Gerrits; Ulf Hanefeld; Johannes Brussee; Adrie J J Straathof; Arne van der Gen; Joseph J Heijnen
Development of a process model to describe the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase in an aqueous-organic biphasic reactor.
Biotechnology and bioengineering 2002;77(3):239-47.
2002: JJ Beun; Mark van loosdrecht; Joseph J Heijnen
Aerobic granulation in a sequencing batch airlift reactor.
Water research 2002;36(3):702-12.
2002: I Stückrath; HC Lange; Peter Kötter; Walter M van Gulik; Karl-Dieter Entian; Joseph J Heijnen
Characterization of null mutants of the glyoxylate cycle and gluconeogenic enzymes in S. cerevisiae through metabolic network modeling verified by chemostat cultivation.
Biotechnology and bioengineering 2002;77(1):61-72.
2002: S Salem; D H J G Berends; Joseph J Heijnen; Mark van loosdrecht
Model-based evaluation of a new upgrading concept for N-removal.
Water science and technology : a journal of the International Association on Water Pollution Research 2002;45(6):169-76.
2002: Mark van loosdrecht; Joseph J Heijnen
Modelling of activated sludge processes with structured biomass.
Water science and technology : a journal of the International Association on Water Pollution Research 2002;45(6):13-23.
2001: HC Lange; Michael R Eman; G van Zuijlen; Diana Visser; Jan C van Dam; Johannes Frank; M J de Mattos; Joseph J Heijnen
Improved rapid sampling for in vivo kinetics of intracellular metabolites in Saccharomyces cerevisiae.
Biotechnology and bioengineering 2001;75(4):406-15.
2001: HC Lange; Joseph J Heijnen
Statistical reconciliation of the elemental and molecular biomass composition of Saccharomyces cerevisiae.
Biotechnology and bioengineering 2001;75(3):334-44.
2001: JJ Beun; Joseph J Heijnen; Mark van loosdrecht
N-removal in a granular sludge sequencing batch airlift reactor.
Biotechnology and bioengineering 2001;75(1):82-92.
2001: I Chin-Joe; Adrie J J Straathof; Jack T. Pronk; Jaap A Jongejan; Joseph J Heijnen
Influence of the ethanol and glucose supply rate on the rate and enantioselectivity of 3-oxo ester reduction by baker's yeast.
Biotechnology and bioengineering 2001;75(1):29-38.
2001: Wouter A van Winden; Dick Schipper; Peter Verheijen; Joseph J Heijnen
Innovations in generation and analysis of 2D [(13)C,(1)H] COSY NMR spectra for metabolic flux analysis purposes.
Metabolic engineering 2001;3(4):322-43.
2001: Wouter A van Winden; Joseph J Heijnen; Peter Verheijen; J Grievink
A priori analysis of metabolic flux identifiability from (13)C-labeling data.
Biotechnology and bioengineering 2001;74(6):505-16.
2001: S C F Meijer; Mark van loosdrecht; Joseph J Heijnen
Metabolic modelling of full-scale biological nitrogen and phosphorus removing wwtp's.
Water research 2001;35(11):2711-23.
2001: F Carta; JJ Beun; Mark van loosdrecht; Joseph J Heijnen
Simultaneous storage and degradation of PHB and glycogen in activated sludge cultures.
Water research 2001;35(11):2693-701.
2001: K Dircks; JJ Beun; Mark van loosdrecht; Joseph J Heijnen; Mogens Henze
Glycogen metabolism in aerobic mixed cultures.
Biotechnology and bioengineering 2001;73(2):85-94.
2001: Hans Roubos; Preben Krabben; R G Luiten; H B Verbruggen; Joseph J Heijnen
A quantitative approach to characterizing cell lysis caused by mechanical agitation of Streptomyces clavuligerus.
Biotechnology progress 2001;17(2):336-47.
2001: Cristian Picioreanu; Mark van loosdrecht; Joseph J Heijnen
Two-dimensional model of biofilm detachment caused by internal stress from liquid flow.
Biotechnology and bioengineering 2001;72(2):205-18.
2001: W M vanGulik; Maciek Antoniewicz; W T deLaat; Jacobus L Vinke; Joseph J Heijnen
Energetics of growth and penicillin production in a high-producing strain of Penicillium chrysogenum.
Biotechnology and bioengineering 2001;72(2):185-93.
2001: Ulf Hanefeld; G Stranzl; Adrie J J Straathof; Joseph J Heijnen; A Bergmann; R Mittelbach; Otto Glatter; Christoph Kratky
Electrospray ionization mass spectrometry, circular dichroism and SAXS studies of the (S)-hydroxynitrile lyase from Hevea brasiliensis.
Biochimica et biophysica acta 2001;1544(1-2):133-42.
2001: Joseph J Heijnen
New experimental and theoretical tools for metabolic engineering of micro-organisms.
Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) 2001;66(3a):11-30.
2000: P L Overbeeke; Jaap A Jongejan; Joseph J Heijnen
Solvent effect on lipase enantioselectivity. Evidence for the presence of two thermodynamic states.
Biotechnology and bioengineering 2000;70(3):278-90.
2000: Cristian Picioreanu; Mark van loosdrecht; Joseph J Heijnen
Effect of diffusive and convective substrate transport on biofilm structure formation: a two-dimensional modeling study.
Biotechnology and bioengineering 2000;69(5):504-15.
2000: I Chin-Joe; P M Nelisse; Adrie J J Straathof; Jaap A Jongejan; Jack T. Pronk; Joseph J Heijnen
Hydrolytic activity in baker's yeast limits the yield of asymmetric 3-oxo ester reduction.
Biotechnology and bioengineering 2000;69(4):370-6.
2000: Walter M van Gulik; Wim T A M de Laat; Jacobus L Vinke; Joseph J Heijnen
Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G.
Biotechnology and bioengineering 2000;68(6):602-18.
2000: JJ Beun; E V Verhoef; Mark van loosdrecht; Joseph J Heijnen
Stoichiometry and kinetics of poly-beta-hydroxybutyrate metabolism under denitrifying conditions in activated sludge cultures.
Biotechnology and bioengineering 2000;68(5):496-507.
2000: Cristian Picioreanu; Mark van loosdrecht; Joseph J Heijnen
A theoretical study on the effect of surface roughness on mass transport and transformation in biofilms.
Biotechnology and bioengineering 2000;68(4):355-69.
2000: JJ Beun; F Paletta; Mark van loosdrecht; Joseph J Heijnen
Stoichiometry and kinetics of poly-beta-hydroxybutyrate metabolism in aerobic, slow growing, activated sludge cultures.
Biotechnology and bioengineering 2000;67(4):379-89.
1999: M J Litjens; M Sha; Adrie J J Straathof; Jaap A Jongejan; Joseph J Heijnen
Competitive lipase-catalyzed ester hydrolysis and ammoniolysis in organic solvents; equilibrium model of a solid-liquid-vapor system.
Biotechnology and bioengineering 1999;65(3):347-56.
1999: Ulf Hanefeld; Adrie J J Straathof; Joseph J Heijnen
Study of the (S)-hydroxynitrile lyase from Hevea brasiliensis: mechanistic implications.
Biochimica et biophysica acta 1999;1432(2):185-93.
1999: Anders wolff; L Zhu; Y W Wong; Adrie J J Straathof; Jaap A Jongejan; Joseph J Heijnen
Understanding the influence of temperature change and cosolvent addition on conversion rate of enzymatic suspension reactions based on regime analysis.
Biotechnology and bioengineering 1999;62(2):125-34.
1999: J E Schlatmann; H J ten Hoopen; Joseph J Heijnen
A simple structured model for maintenance, biomass formation, and ajmalicine production by nondividing Catharanthus roseus cells.
Biotechnology and bioengineering 1999;66(3):147-57.
1998: Cristiano Nicolella; Mark van loosdrecht; Rob G J M van der Lans; Joseph J Heijnen
Hydrodynamic characteristics and gas-liquid mass transfer in a biofilm airlift suspension reactor.
Biotechnology and bioengineering 1998;60(5):627-35.
1998: D A van Scherpenzeel; M Boon; Cor Ras; G S Hansford; Joseph J Heijnen
Kinetics of ferrous iron oxidation by Leptospirillum bacteria in continuous cultures.
Biotechnology progress 1998;14(3):425-33.
1998: Cristian Picioreanu; Mark van loosdrecht; Joseph J Heijnen
Mathematical modeling of biofilm structure with a hybrid differential-discrete cellular automaton approach.
Biotechnology and bioengineering 1998;58(1):101-16.
1998: Cristian Picioreanu; Mark van loosdrecht; Joseph J Heijnen
A new combined differential-discrete cellular automaton approach for biofilm modeling: application for growth in gel beads.
Biotechnology and bioengineering 1998;57(6):718-31.
1997: Anders wolff; Lianjie Zhu; V Kielland; Adrie J J Straathof; Jaap A Jongejan; Joseph J Heijnen
Simple dissolution-reaction model for enzymatic conversion of suspension of solid substrate.
Biotechnology and bioengineering 1997;56(4):433-40.
1997: A Gjaltema; N van der Marel; Mark van loosdrecht; Joseph J Heijnen
Adhesion and biofilm development on suspended carriers in airlift reactors: hydrodynamic conditions versus surface characteristics.
Biotechnology and bioengineering 1997;55(6):880-9.
1997: M A van Aalst-van Leeuwen; M A Pot; Mark van loosdrecht; Joseph J Heijnen
Kinetic modeling of poly(beta-hydroxybutyrate) production and consumption by Paracoccus pantotrophus under dynamic substrate supply.
Biotechnology and bioengineering 1997;55(5):773-82.
1997: A Gjaltema; Mark van loosdrecht; Joseph J Heijnen
Abrasion of suspended biofilm pellets in airlift reactors: effect of particle size.
Biotechnology and bioengineering 1997;55(1):206-15.
1997: E Murnleitner; T Kuba; Mark van loosdrecht; Joseph J Heijnen
An integrated metabolic model for the aerobic and denitrifying biological phosphorus removal.
Biotechnology and bioengineering 1997;54(5):434-50.
1997: W A van Benthum; Mark van loosdrecht; Joseph J Heijnen
Control of heterotrophic layer formation on nitrifying biofilms in a biofilm airlift suspension reactor.
Biotechnology and bioengineering 1997;53(4):397-405.
1997: Mark van loosdrecht; G J Smolders; T Kuba; Joseph J Heijnen
Metabolism of micro-organisms responsible for enhanced biological phosphorus removal from wastewater. Use of dynamic enrichment cultures.
Antonie van Leeuwenhoek 1997;71(1-2):109-16.
1997: J M Garrido; W A van Benthum; Mark van loosdrecht; Joseph J Heijnen
Influence of dissolved oxygen concentration on nitrite accumulation in a biofilm airlift suspension reactor.
Biotechnology and bioengineering 1997;53(2):168-78.
1997: A Gjaltema; Jacobus L Vinke; Mark van loosdrecht; Joseph J Heijnen
Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations.
Biotechnology and bioengineering 1997;53(1):88-99.
1996: T Kuba; E Murnleitner; Mark van loosdrecht; Joseph J Heijnen
A metabolic model for biological phosphorus removal by denitrifying organisms.
Biotechnology and bioengineering 1996;52(6):685-95.
1996: Adrie J J Straathof; Joseph J Heijnen
New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants.
Biotechnology and bioengineering 1996;52(3):433-7.
1996: B H van Kleeff; J Gijs Kuenen; Joseph J Heijnen
Heat flux measurements for the fast monitoring of dynamic responses to glucose additions by yeasts that were subjected to different feeding regimes in continuous culture.
Biotechnology progress 1996;12(4):510-8.
1995: M C Hensing; R J Rouwenhorst; Joseph J Heijnen; Johannes P van Dijken; Jack T. Pronk
Physiological and technological aspects of large-scale heterologous-protein production with yeasts.
Antonie van Leeuwenhoek 1995;67(3):261-79.
1994: A Geerlof; J J Rakels; Adrie J J Straathof; Joseph J Heijnen; Jaap A Jongejan; Johannis A Duine
Description of the kinetic mechanism and the enantioselectivity of quinohaemoprotein ethanol dehydrogenase from Comamonas testosteroni in the oxidation of alcohols and aldehydes.
European journal of biochemistry / FEBS 1994;226(2):537-46.
1993: J L Rakels; Adrie J J Straathof; Joseph J Heijnen
A simple method to determine the enantiomeric ratio in enantioselective biocatalysis.
Enzyme and microbial technology 1993;15(12):1051-6.
1993: Paulo Roberto Moreno; J E Schlatmann; Robert van der Heijden; W M van Gulik; H J ten Hoopen; Robert Verpoorte; Joseph J Heijnen
Induction of ajmalicine formation and related enzyme activities in Catharanthus roseus cells: effect of inoculum density.
Applied microbiology and biotechnology 1993;39(1):42-7.
1992: Joseph J Heijnen; A H Terwisscha van Scheltinga; Adrie J J Straathof
Fundamental bottlenecks in the application of continuous bioprocesses.
Journal of biotechnology 1992;22(1-2):3-20.
1991: Joseph J Heijnen
A new thermodynamically based correlation of chemotrophic biomass yields.
Antonie van Leeuwenhoek 1991;60(3-4):235-56.