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Päivi Heikkilä

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TJ Meretoja; R M Nadeem; A Perhavec; Peter Regitnig; Z A Saidan; Anna Sapino; I Sejben; T Takács; T F Tvedskov; Vania Vezzosi; Janez Zgajnar; R Lousquy; Gero Luschin-Ebengreuth; RICCARDO ARISIO; Riccardo A Audisio; E Barranger; S Bianchi; Rita Bori; Isabella Castellano; G Cserni; M P Foschini; B Gazic; Päivi Heikkilä; S Imoto; M-B Jensen; H Kamma; B Kővári; György Lázár; Marjut Leidenius
International multicenter tool to predict the risk of four or more tumor-positive axillary lymph nodes in breast cancer patients with sentinel node macrometastases.
Kristiina Joensuu; Mia Kero; Marjut Leidenius; Leif C Andersson; Kathryn B Horwitz; Päivi Heikkilä
ER, PR, HER2, Ki-67 and CK5 in Early and Late Relapsing Breast Cancer-Reduced CK5 Expression in Metastases.
Leena Strien; Marjut Leidenius; Päivi Heikkilä
False-positive and false-negative sentinel node findings in 473 breast cancers.

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All Publications

2013: TJ Meretoja; R M Nadeem; A Perhavec; Peter Regitnig; Z A Saidan; Anna Sapino; I Sejben; T Takács; T F Tvedskov; Vania Vezzosi; Janez Zgajnar; R Lousquy; Gero Luschin-Ebengreuth; RICCARDO ARISIO; Riccardo A Audisio; E Barranger; S Bianchi; Rita Bori; Isabella Castellano; G Cserni; M P Foschini; B Gazic; Päivi Heikkilä; S Imoto; M-B Jensen; H Kamma; B Kővári; György Lázár; Marjut Leidenius
International multicenter tool to predict the risk of four or more tumor-positive axillary lymph nodes in breast cancer patients with sentinel node macrometastases.
Breast cancer research and treatment 2013;138(3):817-27.
2013: Kristiina Joensuu; Mia Kero; Marjut Leidenius; Leif C Andersson; Kathryn B Horwitz; Päivi Heikkilä
ER, PR, HER2, Ki-67 and CK5 in Early and Late Relapsing Breast Cancer-Reduced CK5 Expression in Metastases.
Breast cancer : basic and clinical research 2013;7():23-34.
2012: Leena Strien; Marjut Leidenius; Päivi Heikkilä
False-positive and false-negative sentinel node findings in 473 breast cancers.
Human pathology 2012;43(11):1940-7.
2012: Göran Jönsson; Niklas Loman; Kristina Lövgren; Linda Magnusson; Per Malmström; Heli Nevanlinna; Håkan Olsson; Camilla Persson; Markus Ringnér; Lao H Saal; Johan Staaf; Johan Vallon-Christersson; Rainer Fagerholm; Mårten Fernö; Dorthe Grabau; Sofia K Gruvberger-Saal; Cecilia Hegardt; Päivi Heikkilä; Karolina Holm; Oskar T Johannsson; Ellinor Johnsson; Bjarni A Agnarsson; Adalgeir Arason; Rosa B Barkardottir; Åke Borg
The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer.
Cancer research 2012;72(16):4028-36.
2012: Liisa M Pelttari; Johanna Schleutker; Riikka Nurminen; Lauri A Aaltonen; Kristiina Aittomäki; Carl Blomqvist; Ralf Bützow; Alexandra Gylfe; Päivi Heikkilä; Anne Kallioniemi; Johanna Kiiski; Arto Leminen; Heli Nevanlinna
A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer.
Journal of medical genetics 2012;49(7):429-32.
2012: TJ Meretoja; K Salmenkivi; Päivi Heikkilä; Marjut Leidenius
Outcome of patients with ductal carcinoma in situ and sentinel node biopsy.
Annals of surgical oncology 2012;19(7):2345-51.
2012: Maral Jamshidi; Jiri Lukas; Johanna Mattson; Kristiina Aittomäki; Jiri Bartek; Jirina Bartkova; Carl Blomqvist; Rainer Fagerholm; Dario Greco; Päivi Heikkilä; Johanna Tommiska; Kenneth Villman; Radek Vrtel; Heli Nevanlinna
NQO1 expression correlates inversely with NFκB activation in human breast cancer.
Breast cancer research and treatment 2012;132(3):955-68.
2012: TJ Meretoja; L Strien; Päivi Heikkilä; Marjut Leidenius
A simple nomogram to evaluate the risk of nonsentinel node metastases in breast cancer patients with minimal sentinel node involvement.
Annals of surgical oncology 2012;19(2):567-76.
2011: Mira Heinonen; Annabrita Hemmes; Marko Laakso; Marjut Leidenius; Kotb Abdelmohsen; Myriam Gorospe; Caj Haglund; Sampsa Hautaniemi; Päivi Heikkilä; Kaisa Salmenkivi; Tuula Salo; Suvi-Tuuli Vilén; Ari Ristimäki
Role of RNA binding protein HuR in ductal carcinoma in situ of the breast.
The Journal of pathology 2011;224(4):529-39.
2011: Kristiina Joensuu; Marjut Leidenius; Hannu Sariola; Leif C Andersson; Caj Haglund; Jaana Hagström; Päivi Heikkilä
Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases--elevated Bmi-1 expression in late breast cancer relapses.
Virchows Archiv : an international journal of pathology 2011;459(1):31-9.
2011: Laura C Hautala; Päivi Heikkilä; Tuomas Heikkinen; Hannu Koistinen; Riitta Koistinen; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Heli Nevanlinna
Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and familial non-BRCA1/2 breast cancer patients.
Breast cancer research and treatment 2011;128(1):85-95.
2011: Suvi Renkonen; Valtteri Häyry; Päivi Heikkilä; Ilmo Leivo; Caj Haglund; Antti A Mäkitie; Jaana Hagström
Stem cell-related proteins C-KIT, C-MYC and BMI-1 in juvenile nasopharyngeal angiofibroma--do they have a role?
Virchows Archiv : an international journal of pathology 2011;458(2):189-95.
2011: Tuomas Heikkinen; Liisa M Pelttari; Johanna Tommiska; Pia Vahteristo; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Päivi Heikkilä; Heli Nevanlinna
Variants on the promoter region of PTEN affect breast cancer progression and patient survival.
Breast cancer research : BCR 2011;13(6):R130.
2011: Hanna Peurala; Kristiina Aittomäki; Jiri Bartek; Jirina Bartkova; Carl Blomqvist; Ralf Bützow; Dario Greco; Päivi Heikkilä; Tuomas Heikkinen; Maral Jamshidi; Sippy Kaur; Heli Nevanlinna
MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer.
PloS one 2011;6(11):e26122.
2011: Harri Sihto; Taina Turpeenniemi-Hujanen; Päivi Heikkilä; Kaija Holli; Jorma Isola; Vesa Kataja; Tiina Lehtimäki; Johan Lundin; Mikael Lundin; Ari Ristimäki; Liisa Sailas; Heikki Joensuu
Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study.
Breast cancer research : BCR 2011;13(5):R87.
2011: Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Ake Borg; Rainer Fagerholm; Dario Greco; Päivi Heikkilä; Kati Kämpjärvi; Outi Kilpivaara; Heli Nevanlinna
Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.
Breast cancer research : BCR 2011;13(5):R90.
2011: E T Siponen; L Vaalavirta; H Joensuu; Jaana Vironen; Päivi Heikkilä; Marjut Leidenius
Ipsilateral breast recurrence after breast conserving surgery in patients with small (≤ 2cm) breast cancer treated with modern adjuvant therapies.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2011;37(1):25-31.
2010: TJ Meretoja; Heikki Joensuu; Päivi Heikkilä; Marjut Leidenius
Safety of sentinel node biopsy in breast cancer patients who receive a second radioisotope injection after visualization failure in lymphoscintigraphy.
Journal of surgical oncology 2010;102(6):649-55.
2010: Elina Siponen; K Hukkinen; Päivi Heikkilä; Heikki Joensuu; Marjut Leidenius
Surgical treatment in Paget's disease of the breast.
American journal of surgery 2010;200(2):241-6.
2010: Johanna Soikkeli; Piotr Podlasz; Miao Yin; Pirjo Nummela; Tiina Jahkola; Susanna Virolainen; Leena Anneli Krogerus; Päivi Heikkilä; Karl von Smitten; Olli Saksela; Erkki Hölttä
Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth.
The American journal of pathology 2010;177(1):387-403.
2010: Leena Strien; Marjut Leidenius; Karl von Smitten; Päivi Heikkilä
Concordance between HER-2 and steroid hormone receptor expression between primary breast cancer, sentinel node metastases, and isolated tumor cells.
Pathology, research and practice 2010;206(4):253-8.
2010: Göran Jönsson; Johan Staaf; Johan Vallon-Christersson; Markus Ringnér; Karolina Holm; Cecilia Hegardt; Haukur Gunnarsson; Rainer Fagerholm; Carina Strand; Bjarni A Agnarsson; Outi Kilpivaara; Lena Luts; Päivi Heikkilä; Kristiina Aittomäki; Carl Blomqvist; Niklas Loman; Per Malmström; Håkan Olsson; Oskar Th Johannsson; Adalgeir Arason; Heli Nevanlinna; Rosa B Barkardottir; Ake Borg
Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics.
Breast cancer research : BCR 2010;12(3):R42.
2009: Sanna Toiviainen-Salo; Peter Roy Durie; Kirsti Numminen; Päivi Heikkilä; Eino Marttinen; Erkki Savilahti; Outi Mäkitie
The natural history of Shwachman-Diamond syndrome-associated liver disease from childhood to adulthood.
The Journal of pediatrics 2009;155(6):807-811.e2.
2009: V Häyry; Kaisa Salmenkivi; Johanna Arola; Päivi Heikkilä; Caj Haglund; Hannu Sariola
High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma.
Endocrine-related cancer 2009;16(4):1211-8.
2009: Tuomas Heikkinen; Hanni Kärkkäinen; Kirsimari Aaltonen; Roger L Milne; Päivi Heikkilä; Kristiina Aittomäki; Carl Blomqvist; Heli Nevanlinna
The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(9):3214-22.
2009: Kirsimari Aaltonen; Rose-Marie Amini; Päivi Heikkilä; Kristiina Aittomäki; Anitta Tamminen; Heli Nevanlinna; Carl Blomqvist
High cyclin B1 expression is associated with poor survival in breast cancer.
British journal of cancer 2009;100(7):1055-60.
2008: Jirina Bartkova; Johanna Tommiska; Lenka Oplustilova; Kirsimari Aaltonen; Anitta Tamminen; Tuomas Heikkinen; Martin Mistrik; Kristiina Aittomäki; Carl Blomqvist; Päivi Heikkilä; Jiri Lukas; Heli Nevanlinna; Jiri Bartek
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Molecular oncology 2008;2(4):296-316.
2008: Tiina Kuulasmaa; Jarmo Jääskeläinen; Suvikki Suppola; Timo Pietiläinen; Päivi Heikkilä; S Aaltomaa; Veli-Matti Kosma; Raimo Voutilainen
WNT-4 mRNA expression in human adrenocortical tumors and cultured adrenal cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(10):668-73.
2008: Rainer Fagerholm; Barbara Hofstetter; Johanna Tommiska; Kirsimari Aaltonen; Radek Vrtel; Kirsi Syrjäkoski; Anne Kallioniemi; Outi Kilpivaara; Arto Mannermaa; Veli-Matti Kosma; Matti Uusitupa; Matti Eskelinen; Vesa Kataja; Kristiina Aittomäki; Karl von Smitten; Päivi Heikkilä; Jiri Lukas; Kaija Holli; Jirina Bartkova; Carl Blomqvist; Jiri Bartek; Heli Nevanlinna
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.
Nature genetics 2008;40(7):844-53.
2008: Marjut Leidenius; L Vaalavirta; Päivi Heikkilä; Karl von Smitten; Kaisa Salmenkivi
The prevalence of and risk factors for four or more metastatic axillary lymph nodes in breast cancer patients undergoing sentinel node biopsy.
Journal of surgical oncology 2008;98(1):21-6.
2008: Kristiina Joensuu; Päivi Heikkilä; Leif C Andersson
Tumor dormancy: elevated expression of stanniocalcins in late relapsing breast cancer.
Cancer letters 2008;265(1):76-83.
2008: Johanna Tommiska; Jirina Bartkova; M Heinonen; L Hautala; Outi Kilpivaara; Hannaleena Eerola; Kristiina Aittomäki; B Hofstetter; J Lukas; Karl von Smitten; Carl Blomqvist; Ari Ristimäki; Päivi Heikkilä; Jiri Bartek; Heli Nevanlinna
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer.
Oncogene 2008;27(17):2501-6.
2008: Kirsimari Aaltonen; Carl Blomqvist; Rose-Marie Amini; Hannaleena Eerola; Kristiina Aittomäki; Päivi Heikkilä; Heli Nevanlinna
Familial breast cancers without mutations in BRCA1 or BRCA2 have low cyclin E and high cyclin D1 in contrast to cancers in BRCA mutation carriers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):1976-83.
2008: Hannaleena Eerola; Mira Heinonen; Päivi Heikkilä; Outi Kilpivaara; Anitta Tamminen; Kristiina Aittomäki; Carl Blomqvist; Ari Ristimäki; Heli Nevanlinna
Basal cytokeratins in breast tumours among BRCA1, BRCA2 and mutation-negative breast cancer families.
Breast cancer research : BCR 2008;10(1):R17.
2007: Mira Heinonen; Rainer Fagerholm; Kirsimari Aaltonen; Outi Kilpivaara; Kristiina Aittomäki; Carl Blomqvist; Päivi Heikkilä; Caj Haglund; Heli Nevanlinna; Ari Ristimäki
Prognostic role of HuR in hereditary breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):6959-63.
2007: TJ Meretoja; Karl von Smitten; Marjut Leidenius; Catarina Svarvar; Päivi Heikkilä; Tiina Jahkola
Local recurrence of stage 1 and 2 breast cancer after skin-sparing mastectomy and immediate breast reconstruction in a 15-year series.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2007;33(10):1142-5.
2007: TJ Meretoja; Tiina Jahkola; Terttu Toivonen; Leena Anneli Krogerus; Päivi Heikkilä; Karl von Smitten; Marjut Leidenius
Sentinel node biopsy with intraoperative diagnosis in patients undergoing skin-sparing mastectomy and immediate breast reconstruction.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2007;33(10):1146-9.
2007: Rose-Marie Amini; Kirsimari Aaltonen; Heli Nevanlinna; Ricardo Carvalho; Laura Salonen; Päivi Heikkilä; Carl Blomqvist
Mast cells and eosinophils in invasive breast carcinoma.
BMC cancer 2007;7():165.
2007: Junnu Leikola; Päivi Heikkilä; Martti Pamilo; Kaisa Salmenkivi; Karl von Smitten; Marjut Leidenius
Predicting invasion in patients with DCIS in the preoperative percutaneous biopsy.
Acta oncologica (Stockholm, Sweden) 2007;46(6):798-802.
2006: Marjut Leidenius; Kaisa Salmenkivi; Karl von Smitten; Päivi Heikkilä
Tumour-positive sentinel node findings in patients with ductal carcinoma in situ.
Journal of surgical oncology 2006;94(5):380-4.
2006: Anu Anttonen; Sirpa Leppä; Päivi Heikkilä; Reidar Grenman; Heikki Joensuu
Effect of treatment of larynx and hypopharynx carcinomas on serum syndecan-1 concentrations.
Journal of cancer research and clinical oncology 2006;132(7):451-7.
2006: Kirsimari Aaltonen; C Ahlin; Rose-Marie Amini; Laura Salonen; Marie-Louise Fjällskog; Päivi Heikkilä; Heli Nevanlinna; Carl Blomqvist
Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides.
British journal of cancer 2006;94(11):1697-702.
2006: Sebsebe Lemeta; Kaisa Salmenkivi; Lea Pylkkänen; Markku Sainio; Sirkku Saarikoski; Johanna Arola; Päivi Heikkilä; Caj Haglund; Kirsti Husgafvel-Pursiainen; Tom Böhling
Frequent loss of heterozygosity at 6q in pheochromocytoma.
Human pathology 2006;37(6):749-54.
2006: Junnu Leikola; Päivi Heikkilä; Karl von Smitten; Marjut Leidenius
The prevalence of axillary lymph-node metastases in patients with pure tubular carcinoma of the breast and sentinel node biopsy.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2006;32(5):488-91.
2006: Johanna Tommiska; Sheila Seal; Anthony Renwick; Rita Barfoot; Linda Baskcomb; Hiran Jayatilake; Jirina Bartkova; Jonna Tallila; Milja Kaare; Anitta Tamminen; Päivi Heikkilä; D Gareth Evans; Diana Eccles; Kristiina Aittomäki; Carl Blomqvist; Jiri Bartek; Michael R Stratton; Heli Nevanlinna; Nazneen Rahman
Evaluation of RAD50 in familial breast cancer predisposition.
International journal of cancer. Journal international du cancer 2006;118(11):2911-6.
2006: Päivi Heikkilä; Juho Suojanen; Emma Pirilä; Anu Väänänen; Erkki Koivunen; Timo Sorsa; Tuula Salo
Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides.
International journal of cancer. Journal international du cancer 2006;118(9):2202-9.
2005: Johanna Tommiska; Hannaleena Eerola; Mira Heinonen; Laura Salonen; Milja Kaare; Jonna Tallila; Ari Ristimäki; Karl von Smitten; Kristiina Aittomäki; Päivi Heikkilä; Carl Blomqvist; Heli Nevanlinna
Breast cancer patients with p53 Pro72 homozygous genotype have a poorer survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5098-103.
2005: Katariina Cederqvist; Caj Haglund; Päivi Heikkilä; Morley D Hollenberg; Riitta Karikoski; Sture Andersson
High expression of pulmonary proteinase-activated receptor 2 in acute and chronic lung injury in preterm infants.
Pediatric research 2005;57(6):831-6.
2005: Sanne Kiiveri; Jianqi Liu; Johanna Arola; Päivi Heikkilä; Tiina Kuulasmaa; Eero Lehtonen; Raimo Voutilainen; Markku Heikinheimo
Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors.
Molecular and cellular endocrinology 2005;233(1-2):47-56.
2005: Outi Kilpivaara; Jirina Bartkova; Hannaleena Eerola; Kirsi Syrjäkoski; Pia Vahteristo; Jiri Lukas; Carl Blomqvist; Kaija Holli; Päivi Heikkilä; Guido Sauter; Olli Kallioniemi; Jiri Bartek; Heli Nevanlinna
Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients.
International journal of cancer. Journal international du cancer 2005;113(4):575-80.
2005: Hannaleena Eerola; Päivi Heikkilä; Anitta Tamminen; Kristiina Aittomäki; Carl Blomqvist; Heli Nevanlinna
Relationship of patients' age to histopathological features of breast tumours in BRCA1 and BRCA2 and mutation-negative breast cancer families.
Breast cancer research : BCR 2005;7(4):R465-9.
2005: Hannaleena Eerola; Päivi Heikkilä; Anitta Tamminen; Kristiina Aittomäki; Carl Blomqvist; Heli Nevanlinna
Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families.
Breast cancer research : BCR 2005;7(1):R93-100.
2005: Ville Bister; Mikko T Salmela; Päivi Heikkilä; Annaleena Anttila; Risto J Rintala; Keiichi Isaka; Sture Andersson; Ulpu Saarialho-Kere
Matrilysins-1 and -2 (MMP-7 and -26) and metalloelastase (MMP-12), unlike MMP-19, are up-regulated in necrotizing enterocolitis.
Journal of pediatric gastroenterology and nutrition 2005;40(1):60-6.
2004: Sanne Kiiveri; Jianqi Liu; Päivi Heikkilä; Johanna Arola; Eero Lehtonen; Raimo Voutilainen; Markku Heikinheimo
Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors.
Endocrine research 2004;30(4):919-23.
2004: Petri Bono; Veli-Matti Wasenius; Päivi Heikkilä; Johan Lundin; David G Jackson; Heikki Joensuu
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(21):7144-9.
2004: Jianqi Liu; X-D Li; Ari Ora; Päivi Heikkilä; A Vaheri; Raimo Voutilainen
cAMP-dependent protein kinase activation inhibits proliferation and enhances apoptotic effect of tumor necrosis factor-alpha in NCI-H295R adrenocortical cells.
Journal of molecular endocrinology 2004;33(2):511-22.
2004: Outi Kilpivaara; Pia Vahteristo; Jacob Falck; Kirsi Syrjäkoski; Hannaleena Eerola; Douglas Easton; Jirina Bartkova; Jiri Lukas; Päivi Heikkilä; Kristiina Aittomäki; Kaija Holli; Carl Blomqvist; Olli Kallioniemi; Jiri Bartek; Heli Nevanlinna
CHEK2 variant I157T may be associated with increased breast cancer risk.
International journal of cancer. Journal international du cancer 2004;111(4):543-7.
2004: Kaisa Salmenkivi; Päivi Heikkilä; Caj Haglund; Johanna Arola
Malignancy in pheochromocytomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2004;112(9):551-9.
2004: Hrefna Kristin Johannsdottir; Gudrun Johannesdottir; Bjarni A Agnarsson; Hannaleena Eerola; Adalgeir Arason; Oskar T Johannsson; Päivi Heikkilä; Valgardur Egilsson; Hakan Olsson; Ake Borg; Heli Nevanlinna; Rosa B Barkardottir
Deletions on chromosome 4 in sporadic and BRCA mutated tumors and association with pathological variables.
Anticancer research 2004;24(5A):2681-7.
2003: Susanna Siltanen; Päivi Heikkilä; Malgorzata Bielinska; David B Wilson; Markku Heikinheimo
Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas.
Pediatric research 2003;54(4):542-6.
2003: Katariina Cederqvist; Caj Haglund; Päivi Heikkilä; Timo Sorsa; Taina Tervahartiala; Ulf-Hakan Stenman; Sture Andersson
Pulmonary trypsin-2 in the development of bronchopulmonary dysplasia in preterm infants.
Pediatrics 2003;112(3 Pt 1):570-7.
2003: Fan Zhang; Mikael Lundin; Ari Ristimäki; Päivi Heikkilä; Johan Lundin; Jorma Isola; Heikki Joensuu; Marikki Laiho
Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomas.
Cancer research 2003;63(16):5005-10.
2003: Patrik Lassus; Päivi Heikkilä; Leif C Andersson; Kristina von Boguslawski; Sture Andersson
Lower concentration of pulmonary hepatocyte growth factor is associated with more severe lung disease in preterm infants.
The Journal of pediatrics 2003;143(2):199-202.
2003: Kaisa Salmenkivi; Päivi Heikkilä; Caj Haglund; Johanna Louhimo; Johanna Arola
Lack of histologically suspicious features, proliferative activity, and p53 expression suggests benign diagnosis in phaeochromocytomas.
Histopathology 2003;43(1):62-71.
2003: Päivi Heikkilä; Olli Teronen; Martti Y Hirn; Timo Sorsa; Taina Tervahartiala; Tuula Salo; Yrjö T Konttinen; Tuula Halttunen; Merja Moilanen; roeland hanemaaijer; Minna Laitinen
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
The Journal of surgical research 2003;111(1):45-52.
2003: Liisa Hovi; Sakari Wikström; Kim Vettenranta; Päivi Heikkilä; Ulla M Saarinen-Pihkala
Adrenocortical carcinoma in children: a role for etoposide and cisplatin adjuvant therapy? Preliminary report.
Medical and pediatric oncology 2003;40(5):324-6.
2003: Kaisa Salmenkivi; Päivi Heikkilä; Jianqi Liu; Caj Haglund; Johanna Arola
VEGF in 105 pheochromocytomas: enhanced expression correlates with malignant outcome.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003;111(4):458-64.
2002: Pia Vahteristo; Jirina Bartkova; Hannaleena Eerola; Kirsi Syrjäkoski; Salla Ojala; Outi Kilpivaara; Anitta Tamminen; Juha Kononen; Kristiina Aittomäki; Päivi Heikkilä; Kaija Holli; Carl Blomqvist; Jiri Bartek; Olli Kallioniemi; Heli Nevanlinna
A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer.
American journal of human genetics 2002;71(2):432-8.
2002: Päivi Heikkilä; Olli Teronen; Merja Moilanen; Yrjö T Konttinen; roeland hanemaaijer; Minna Laitinen; Päivi Maisi; Gabri van der Pluijm; John D Bartlett; Tuula Salo; Timo Sorsa
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines.
Anti-cancer drugs 2002;13(3):245-54.
2002: Juhani Rapola; Päivi Heikkilä; Vineta Fellman
Pathology of lethal fetal growth retardation syndrome with aminoaciduria, iron overload, and lactic acidosis (GRACILE).
Pediatric pathology & molecular medicine 2002;21(2):183-93.
2002: Zhi-He Gao; Suvikki Suppola; Jianqi Liu; Päivi Heikkilä; Juhani Jänne; Raimo Voutilainen
Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors.
The Journal of clinical endocrinology and metabolism 2002;87(3):1170-6.
2001: Patrik Lassus; Maila Turanlahti; Päivi Heikkilä; Leif C Andersson; Irmeli Nupponen; Annikki Sarnesto; Sture Andersson
Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn.
American journal of respiratory and critical care medicine 2001;164(10 Pt 1):1981-7.
2001: Kaisa Salmenkivi; Caj Haglund; A Ristimäki; Johanna Arola; Päivi Heikkilä
Increased expression of cyclooxygenase-2 in malignant pheochromocytomas.
The Journal of clinical endocrinology and metabolism 2001;86(11):5615-9.
2001: Kaisa Salmenkivi; Caj Haglund; Johanna Arola; Päivi Heikkilä
Increased expression of tenascin in pheochromocytomas correlates with malignancy.
The American journal of surgical pathology 2001;25(11):1419-23.
2001: Tiina M Asikainen; Päivi Heikkilä; Riitta Kaarteenaho-Wiik; Vuokko L Kinnula; Kari O Raivio
Cell-specific expression of manganese superoxide dismutase protein in the lungs of patients with respiratory distress syndrome, chronic lung disease, or persistent pulmonary hypertension.
Pediatric pulmonology 2001;32(3):193-200.
2001: Anu Anttonen; Päivi Heikkilä; Mikael Kajanti; M Jalkanen; Heikki Joensuu
High syndecan-1 expression is associated with favourable outcome in squamous cell lung carcinoma treated with radical surgery.
Lung cancer (Amsterdam, Netherlands) 2001;32(3):297-305.
2001: Kaisa Salmenkivi; Johanna Arola; Raimo Voutilainen; V Ilvesmäki; Caj Haglund; AI Kahri; Päivi Heikkilä; Jianqi Liu
Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis.
The Journal of clinical endocrinology and metabolism 2001;86(5):2231-5.
2000: Päivi Heikkilä; Johanna Arola; Raimo Voutilainen; Kaisa Salmenkivi; AI Kahri; J Liu
Expression of vascular endothelial growth factor in human adrenals.
Endocrine research 2000;26(4):867-71.
2000: Johanna Arola; Kaisa Salmenkivi; J Liu; AI Kahri; Päivi Heikkilä
p53 and Ki67 in adrenocortical tumors.
Endocrine research 2000;26(4):861-5.
2000: Antti Koivusalo; H Kauppinen; Annaleena Anttila; Päivi Heikkilä; Risto J Rintala; Harry Lindahl
Rectosigmoid pHi monitoring during experimental necrotizing enterocolitis.
Journal of pediatric surgery 2000;35(10):1462-7.
2000: Johanna Sjöström; Carl Blomqvist; Päivi Heikkilä; K V Boguslawski; A Räisänen-Sokolowski; Nils-Olof Bengtsson; Ingvil Mjaaland; Per Malmström; B Ostenstadt; Jonas Bergh; Erik Wist; Vahur Valvere; Eero Saksela
Predictive value of p53, mdm-2, p21, and mib-1 for chemotherapy response in advanced breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3103-10.
2000: Jianqi Liu; Päivi Heikkilä; QH Meng; AI Kahri; Matti J Tikkanen; Raimo Voutilainen
Expression of low and high density lipoprotein receptor genes in human adrenals.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(6):677-82.
2000: Jianqi Liu; Päivi Heikkilä; AI Kahri; Raimo Voutilainen
Expression of activin A and its receptors in human pheochromocytomas.
The Journal of endocrinology 2000;165(2):503-8.
2000: Johanna Arola; Jianqi Liu; Päivi Heikkilä; V Ilvesmäki; Kaisa Salmenkivi; Raimo Voutilainen; AI Kahri
Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm.
The Journal of endocrinology 2000;165(2):223-9.
1999: Susanna Siltanen; Mikko Anttonen; Päivi Heikkilä; Naoko Narita; Mika P E Laitinen; Olli Ritvos; David B Wilson; Markku Heikinheimo
Transcription factor GATA-4 is expressed in pediatric yolk sac tumors.
The American journal of pathology 1999;155(6):1823-9.
1999: Jianqi Liu; AI Kahri; Päivi Heikkilä; Raimo Voutilainen
Regulation of neuropeptide Y mRNA expression in cultured human pheochromocytoma cells.
European journal of endocrinology / European Federation of Endocrine Societies 1999;141(4):431-5.
1999: Erkki Koivunen; Wadih Arap; Heli Valtanen; A Rainisalo; Oula Penate Medina; Päivi Heikkilä; C Kantor; Carl G Gahmberg; Tuula Salo; Yrjö T Konttinen; Timo Sorsa; Erkki Ruoslahti; Renata Pasqualini
Tumor targeting with a selective gelatinase inhibitor.
Nature biotechnology 1999;17(8):768-74.
1999: Olli Teronen; Päivi Heikkilä; Yrjö T Konttinen; Minna Laitinen; Tuula Salo; roeland hanemaaijer; A Teronen; Päivi Maisi; Timo Sorsa
MMP inhibition and downregulation by bisphosphonates.
Annals of the New York Academy of Sciences 1999;878():453-65.
1999: Jianqi Liu; Raimo Voutilainen; Päivi Heikkilä; AI Kahri
pG2 gene expression and its regulation in human adrenocortical and medullary tumors.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):590-6.
1999: R Valtola; Petri Salven; Päivi Heikkilä; Jussi Taipale; Heikki Joensuu; Marko Rehn; Taina Pihlajaniemi; HA Weich; R deWaal; Kari Alitalo
VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer.
The American journal of pathology 1999;154(5):1381-90.
1999: Anu Anttonen; Mikael Kajanti; Päivi Heikkilä; M Jalkanen; Heikki Joensuu
Syndecan-1 expression has prognostic significance in head and neck carcinoma.
British journal of cancer 1999;79(3-4):558-64.
1998: V Ilvesmäki; Jianqi Liu; Päivi Heikkilä; AI Kahri; Raimo Voutilainen
Expression of insulin-like growth factor binding protein 1-6 genes in adrenocortical tumors and pheochromocytomas.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(10):619-23.
1998: Johanna Arola; Jianqi Liu; Päivi Heikkilä; Raimo Voutilainen; AI Kahri
Expression of inhibin alpha in the human adrenal gland and adrenocortical tumors.
Endocrine research 1998;24(3-4):865-7.
1998: Päivi Heikkilä; Johanna Arola; Jianqi Liu; AI Kahri
ACTH regulates LDL receptor and CLA-1 mRNA in the rat adrenal cortex.
Endocrine research 1998;24(3-4):591-3.
1998: Petri Salven; A Lymboussaki; Päivi Heikkilä; H Jääskela-Saari; B Enholm; Karin Aase; G von Euler; Ulf Eriksson; Kari Alitalo; Heikki Joensuu
Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors.
The American journal of pathology 1998;153(1):103-8.
1998: A Salmi; Päivi Heikkilä; Susanna Lintula; Eeva-Marja Rutanen
Cellular localization of c-jun messenger ribonucleic acid and protein and their relation to the proliferation marker Ki-67 in the human endometrium.
The Journal of clinical endocrinology and metabolism 1998;83(5):1788-96.
1998: Lotta Jussila; R Valtola; Taina A Partanen; Petri Salven; Päivi Heikkilä; M T Matikainen; Risto Renkonen; A Kaipainen; Michael Detmar; E Tschachler; Riitta Alitalo; Kari Alitalo
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3.
Cancer research 1998;58(8):1599-604.
1997: Jianqi Liu; AI Kahri; Päivi Heikkilä; Raimo Voutilainen
Adrenomedullin gene expression and its different regulation in human adrenocortical and medullary tumors.
The Journal of endocrinology 1997;155(3):483-90.
1997: Petri Salven; Päivi Heikkilä; Anu Anttonen; Mikael Kajanti; Heikki Joensuu
Vascular endothelial growth factor in squamous cell head and neck carcinoma: expression and prognostic significance.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1997;10(11):1128-33.
1997: Timo Sorsa; Tuula Salo; Erkki Koivunen; Jaana Tyynelä; Yrjö T Konttinen; Ulrich Bergmann; Ari Tuuttila; E Niemi; Olli Teronen; Päivi Heikkilä; H Tschesche; Jari Leinonen; S Osman; Ulf-Hakan Stenman
Activation of type IV procollagenases by human tumor-associated trypsin-2.
The Journal of biological chemistry 1997;272(34):21067-74.
1997: Jianqi Liu; Raimo Voutilainen; Päivi Heikkilä; AI Kahri
Ribonucleic acid expression of the CLA-1 gene, a human homolog to mouse high density lipoprotein receptor SR-BI, in human adrenal tumors and cultured adrenal cells.
The Journal of clinical endocrinology and metabolism 1997;82(8):2522-7.
1997: Jianqi Liu; AI Kahri; Päivi Heikkilä; Raimo Voutilainen
Ribonucleic acid expression of the clustered imprinted genes, p57KIP2, insulin-like growth factor II, and H19, in adrenal tumors and cultured adrenal cells.
The Journal of clinical endocrinology and metabolism 1997;82(6):1766-71.
1997: Jianqi Liu; Raimo Voutilainen; AI Kahri; Päivi Heikkilä
Expression patterns of the c-myc gene in adrenocortical tumors and pheochromocytomas.
The Journal of endocrinology 1997;152(2):175-81.
1997: Petri Salven; Päivi Heikkilä; Heikki Joensuu
Enhanced expression of vascular endothelial growth factor in metastatic melanoma.
British journal of cancer 1997;76(7):930-4.
1996: AI Kahri; Jianqi Liu; Johanna Arola; Päivi Heikkilä
ACTH-induced selective death of rat adrenocortical cells in primary culture.
Endocrine research 1996;22(4):409-10.
1996: Jianqi Liu; Päivi Heikkilä; AI Kahri; Raimo Voutilainen
Expression of the steroidogenic acute regulatory protein mRNA in adrenal tumors and cultured adrenal cells.
The Journal of endocrinology 1996;150(1):43-50.
1996: P Salvén; Heikki Joensuu; Päivi Heikkilä; M T Matikainen; Veli-Matti Wasenius; A Alanko; Kari Alitalo
Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis.
British journal of cancer 1996;74(1):69-72.
1996: Jianqi Liu; Raimo Voutilainen; AI Kahri; Päivi Heikkilä
Expression of the c-myc gene in human adrenals: regulation by adrenocorticotropin in primary cultures.
The Journal of endocrinology 1996;148(3):523-9.
1995: Päivi Heikkilä; Johanna Arola; A Salmi; AI Kahri
ACTH-induced c-myc proto-oncogene expression precedes antimitogenic effect during differentiation of fetal rat adrenocortical cells.
The Journal of endocrinology 1995;145(2):379-85.
1995: Jianqi Liu; AI Kahri; Päivi Heikkilä; V Ilvesmäki; Raimo Voutilainen
H19 and insulin-like growth factor-II gene expression in adrenal tumors and cultured adrenal cells.
The Journal of clinical endocrinology and metabolism 1995;80(2):492-6.
1994: Johanna Arola; Päivi Heikkilä; Raimo Voutilainen; AI Kahri
Corticosterone regulates cell proliferation and cytochrome P450 cholesterol side-chain cleavage enzyme messenger ribonucleic acid expression in primary cultures of fetal rat adrenals.
Endocrinology 1994;135(5):2064-9.
1994: Jianqi Liu; Päivi Heikkilä; Raimo Voutilainen; S L Karonen; AI Kahri
Pheochromocytoma expressing adrenocorticotropin and corticotropin-releasing hormone; regulation by glucocorticoids and nerve growth factor.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(3):221-8.
1994: Jianqi Liu; AI Kahri; Päivi Heikkilä; Werner Blum; Raimo Voutilainen
Glucocorticoids increase insulin-like growth factor-II mRNA accumulation in cultured human phaeochromocytoma cells.
The Journal of endocrinology 1994;142(1):29-35.
1994: Johanna Arola; Päivi Heikkilä; Raimo Voutilainen; AI Kahri
Protein kinase C signal transduction pathway in ACTH-induced growth effect of rat adrenocortical cells in primary culture.
The Journal of endocrinology 1994;141(2):285-93.
1993: Johanna Arola; Päivi Heikkilä; Raimo Voutilainen; AI Kahri
Role of adenylate cyclase-cyclic AMP-dependent signal transduction in the ACTH-induced biphasic growth effect of rat adrenocortical cells in primary culture.
The Journal of endocrinology 1993;139(3):451-61.
1993: Johanna Arola; Päivi Heikkilä; AI Kahri
Biphasic effect of ACTH on growth of rat adrenocortical cells in primary culture.
Cell and tissue research 1993;271(1):169-76.
1992: Jari Peltonen; AI Kahri; L A Lindberg; Päivi Heikkilä; Erkki O Karaharju; K A Aalto
Bone formation after distraction osteotomy of the radius in sheep.
Acta orthopaedica Scandinavica 1992;63(6):599-603.
1991: P Leinonen; T Ranta; Rita Siegberg; R Pelkonen; Päivi Heikkilä; AI Kahri
Testosterone-secreting virilizing adrenal adenoma with human chorionic gonadotrophin receptors and 21-hydroxylase deficiency.
Clinical endocrinology 1991;34(1):31-5.
1990: Päivi Heikkilä; AI Kahri; Petri Kovanen; Christian Ehnholm
Effects of mevinolin, an inhibitor of cholesterol synthesis, on the morphology and function of differentiating and differentiated rat adrenocortical cells in primary culture.
Cell and tissue research 1990;261(1):125-32.
1990: Päivi Heikkilä
Effects of endogenous and exogenous cholesterol on the ultrastructure and steroid secretion of undifferentiated rat adrenocortical cells in primary culture.
Cell and tissue research 1990;259(3):421-7.
1989: AI Kahri; Päivi Heikkilä; Christian Ehnholm; H Ranki; Petri Kovanen
Sequential expression of high and low density lipoprotein receptors in differentiating fetal rat adrenocortical cells in primary culture.
Endocrinology 1989;125(1):68-75.
1989: Päivi Heikkilä; AI Kahri; Christian Ehnholm; Petri Kovanen
The effect of low- and high-density lipoprotein cholesterol on steroid hormone production and ACTH-induced differentiation of rat adrenocortical cells in primary culture.
Cell and tissue research 1989;256(3):487-94.
1989: P Leinonen; Rita Siegberg; AI Kahri; Päivi Heikkilä
[Post-menopausal virilism].
Duodecim; lääketieteellinen aikakauskirja 1989;105(10):933-40.
1988: Päivi Heikkilä; AI Kahri; Christian Ehnholm; Petri Kovanen
Endogenous cholesterol synthesis is sufficient for ACTH-induced differentiation of rat adrenocortical cells in primary culture.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(9):936-42.