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Jan Heiligers

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Udayasankar Arulmani; Jan P C Heiligers; David Centurion; Ingrid M Garrelds; Carlos M Villalón; Pramod R Saxena
Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs.
Udayasankar Arulmani; Jan P C Heiligers; Ingrid M Garrelds; Araceli Sánchez-López; Edwin W Willems; Carlos M Villalón; Pramod R Saxena
Effects of sumatriptan on capsaicin-induced carotid haemodynamic changes and CGRP release in anaesthetized pigs.
Udayasankar Arulmani; Martin P Schuijt; Jan P C Heiligers; Edwin W Willems; Carlos M Villalón; Pramod R Saxena
Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats.

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All Publications

2005: Udayasankar Arulmani; Jan P C Heiligers; David Centurion; Ingrid M Garrelds; Carlos M Villalón; Pramod R Saxena
Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs.
Cephalalgia : an international journal of headache 2005;25(11):1082-90.
2004: Udayasankar Arulmani; Jan P C Heiligers; Ingrid M Garrelds; Araceli Sánchez-López; Edwin W Willems; Carlos M Villalón; Pramod R Saxena
Effects of sumatriptan on capsaicin-induced carotid haemodynamic changes and CGRP release in anaesthetized pigs.
Cephalalgia : an international journal of headache 2004;24(9):717-27.
2004: Udayasankar Arulmani; Martin P Schuijt; Jan P C Heiligers; Edwin W Willems; Carlos M Villalón; Pramod R Saxena
Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats.
Basic & clinical pharmacology & toxicology 2004;94(6):291-7.
2004: Kapil Kapoor; Edwin W Willems; A Maassen vandenBrink; Jan P C Heiligers; Alex Cordi; Christine Vayssettes-Courchay; Tony J Verbeuren; Carlos M Villalón; Pramod R Saxena
Assessment of anti-migraine potential of a novel alpha-adrenoceptor agonist S19014: effects on porcine carotid and regional haemodynamics and human coronary artery.
Cephalalgia : an international journal of headache 2004;24(6):425-38.
2003: Kapil Kapoor; Udayasankar Arulmani; Jan P C Heiligers; Ingrid M Garrelds; Edwin W Willems; Henri Doods; Carlos M Villalón; Pramod R Saxena
Effects of the CGRP receptor antagonist BIBN4096BS on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs.
British journal of pharmacology 2003;140(2):329-38.
2003: Kapil Kapoor; Udayasankar Arulmani; Jan P C Heiligers; Edwin W Willems; Henri Doods; Carlos M Villalón; Pramod R Saxena
Effects of BIBN4096BS on cardiac output distribution and on CGRP-induced carotid haemodynamic responses in the pig.
European journal of pharmacology 2003;475(1-3):69-77.
2002: Ingrid M Garrelds; Jan P C Heiligers; Marieke E Van Meeteren; Dirk Duncker; Pramod R Saxena; M A C Meijssen; Freek J Zijlstra
Intestinal blood flow in murine colitis induced with dextran sulfate sodium.
Digestive diseases and sciences 2002;47(10):2231-6.
2002: Beril Tom; Peter de Vries; Jan P C Heiligers; Edwin W Willems; Kapil Kapoor; G W John; Pramod R Saxena
Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs.
Cephalalgia : an international journal of headache 2002;22(1):37-47.
2001: Beril Tom; Peter de Vries; Jan P C Heiligers; Edwin W Willems; E Scalbert; P Delagrange; Pramod R Saxena
The lack of vasoconstrictor effect of the pineal hormone melatonin in an animal model predictive of antimigraine activity.
Cephalalgia : an international journal of headache 2001;21(6):656-63.
2001: Edwin W Willems; Jan P C Heiligers; Peter de Vries; Beril Tom; Kapil Kapoor; Carlos M Villalón; Pramod R Saxena
A61603-induced vasoconstriction in porcine carotid vasculature: involvement of a non-adrenergic mechanism.
European journal of pharmacology 2001;417(3):195-201.
2001: Edwin W Willems; Jan P C Heiligers; Peter de Vries; Kapil Kapoor; Beril Tom; Carlos M Villalón; Pramod R Saxena
Alpha1-adrenoceptor subtypes mediating vasoconstriction in the carotid circulation of anaesthetized pigs: possible avenues for antimigraine drug development.
Cephalalgia : an international journal of headache 2001;21(2):110-9.
1999: Edwin W Willems; M Trion; Peter de Vries; Jan P C Heiligers; Carlos M Villalón; Pramod R Saxena
Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs.
British journal of pharmacology 1999;127(5):1263-71.
1999: Peter de Vries; Edwin W Willems; Jan P C Heiligers; Carlos M Villalón; Pramod R Saxena
Investigation of the role of 5-HT1B and 5-HT1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses.
British journal of pharmacology 1999;127(2):405-12.
1999: Peter de Vries; P A De Visser; Jan P C Heiligers; Carlos M Villalón; Pramod R Saxena
Changes in systemic and regional haemodynamics during 5-HT7 receptor-mediated depressor responses in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(4):331-8.
1998: Peter de Vries; Araceli Sánchez-López; David Centurion; Jan P C Heiligers; Pramod R Saxena; Carlos M Villalón
The canine external carotid vasoconstrictor 5-HT1 receptor: blockade by 5-HT1B (SB224289), but not by 5-HT1D (BRL15572) receptor antagonists.
European journal of pharmacology 1998;362(1):69-72.
1998: Edwin W Willems; Peter de Vries; Jan P C Heiligers; Pramod R Saxena
Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(2):212-9.
1998: Pramod R Saxena; Peter de Vries; Jan P C Heiligers; WA Bax; A Maassen vandenBrink; F D Yocca
BMS-181885, a 5-HT1B/1D receptor ligand, in experimental models predictive of antimigraine activity and coronary side-effect potential.
European journal of pharmacology 1998;351(3):329-39.
1998: Peter de Vries; Edwin W Willems; Jan P C Heiligers; Carlos M Villalón; Pramod R Saxena
The antimigraine agent alniditan selectively constricts porcine carotid arteriovenous anastomoses via 5-HT1B/1D receptors.
European journal of pharmacology 1998;351(2):193-201.
1998: Peter de Vries; Carlos M Villalón; Jan P C Heiligers; Pramod R Saxena
Characterization of 5-HT receptors mediating constriction of porcine carotid arteriovenous anastomoses; involvement of 5-HT1B/1D and novel receptors.
British journal of pharmacology 1998;123(8):1561-70.
1997: Carlos M Villalón; Jan P C Heiligers; David Centurion; Peter de Vries; Pramod R Saxena
Characterization of putative 5-HT7 receptors mediating tachycardia in the cat.
British journal of pharmacology 1997;121(6):1187-95.
1997: Peter de Vries; Carlos M Villalón; Jan P C Heiligers; Pramod R Saxena
Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats; close resemblance to the cloned 5-ht7 receptor.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(1):90-9.
1997: Peter de Vries; S Apaydin; Carlos M Villalón; Jan P C Heiligers; Pramod R Saxena
Interactions of GR127935, a 5-HT(1B/D) receptor ligand, with functional 5-HT receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(4):423-30.
1997: Pramod R Saxena; Peter de Vries; W Wang; Jan P C Heiligers; A Maassen vandenBrink; WA Bax; F D Yocca
Effects of avitriptan, a new 5-HT 1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(2):295-302.
1996: Pramod R Saxena; A Maassen vandenBrink; Jan P C Heiligers; E Scalbert; B G Lemaitre
Effects of S20749, a close analogue of sumatriptan, on porcine carotid haemodynamics and human isolated coronary artery.
Pharmacology & toxicology 1996;79(4):199-204.
1996: Pramod R Saxena; Peter de Vries; Jan P C Heiligers; A Maassen vandenBrink; WA Bax; T Barf; H Wikström
Investigations with GMC2021 in experimental models predictive of antimigraine activity and coronary side-effect potential.
European journal of pharmacology 1996;312(1):53-62.
1996: Peter de Vries; Jan P C Heiligers; Carlos M Villalón; Pramod R Saxena
Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a selective 5-HT1D receptor antagonist.
British journal of pharmacology 1996;118(1):85-92.
1993: Tibor Mózes; Jan P C Heiligers; C J Tak; Freek J Zijlstra; S Ben-Efraim; Pramod R Saxena; I L Bonta
Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs.
Prostaglandins, leukotrienes, and essential fatty acids 1993;48(2):193-200.
1992: Pramod R Saxena; Jan P C Heiligers; Carlos M Villalón; M D Ferrari
Effects of tertatolol, a beta-adrenoceptor antagonist with agonist affinity at 5-HT1A receptors, in an animal model of migraine: comparison with propranolol and pindolol.
European journal of pharmacology 1992;220(1):79-86.
1992: Carlos M Villalón; A H Bom; M O Den Boer; Jan P C Heiligers; Pramod R Saxena
Effects of S9977 and dihydroergotamine in an animal experimental model for migraine.
Pharmacological research : the official journal of the Italian Pharmacological Society 1992;25(2):125-37.
1991: Tibor Mózes; Freek J Zijlstra; Jan P C Heiligers; C J Tak; S Ben-Efraim; I L Bonta; Pramod R Saxena
Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetized pigs: protective effects of indomethacin.
British journal of pharmacology 1991;104(3):691-9.
1991: Tibor Mózes; Jan P C Heiligers; C J Tak; Freek J Zijlstra; S Ben-Efraim; Pramod R Saxena; I L Bonta
Platelet activating factor is one of the mediators involved in endotoxic shock in pigs.
Journal of lipid mediators 1991;4(3):309-25.
1991: M O den Boer; Jan P C Heiligers; Pramod R Saxena
Carotid vascular effects of ergotamine and dihydroergotamine in the pig: no exclusive mediation via 5-HT1-like receptors.
British journal of pharmacology 1991;104(1):183-9.
1991: E Marcel van Gelderen; Jan P C Heiligers; Pramod R Saxena
Haemodynamic changes and acetylcholine-induced hypotensive responses after NG-nitro-L-arginine methyl ester in rats and cats.
British journal of pharmacology 1991;103(4):1899-904.
1991: Tibor Mózes; Freek J Zijlstra; Jan P C Heiligers; Pramod R Saxena; I L Bonta
Sequential release of eicosanoids during endotoxin-induced shock in anesthetized pigs.
Prostaglandins, leukotrienes, and essential fatty acids 1991;42(4):209-16.
1991: Tibor Mózes; S Ben-Efraim; C J Tak; Jan P C Heiligers; Pramod R Saxena; I L Bonta
Serum levels of tumor necrosis factor determine the fatal or non-fatal course of endotoxic shock.
Immunology letters 1991;27(2):157-62.
1991: M O den Boer; Carlos M Villalón; Jan P C Heiligers; P P Humphrey; Pramod R Saxena
Role of 5-HT1-like receptors in the reduction of porcine cranial arteriovenous anastomotic shunting by sumatriptan.
British journal of pharmacology 1991;102(2):323-30.
1991: Carlos M Villalón; M O den Boer; Jan P C Heiligers; Pramod R Saxena
Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig.
British journal of pharmacology 1991;102(1):107-12.
1990: Carlos M Villalón; A H Bom; Jan P C Heiligers; M O Den Boer; Pramod R Saxena
Constriction of porcine arteriovenous anastomoses by indorenate is unrelated to 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptor subtypes.
European journal of pharmacology 1990;190(1-2):167-76.
1990: Carlos M Villalón; M O den Boer; Jan P C Heiligers; Pramod R Saxena
Mediation of 5-hydroxytryptamine-induced tachycardia in the pig by the putative 5-HT4 receptor.
British journal of pharmacology 1990;100(4):665-7.
1989: A H Bom; Jan P C Heiligers; Pramod R Saxena; Pieter D Verdouw
Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors.
British journal of pharmacology 1989;97(2):383-90.
1986: Pramod R Saxena; Dirk Duncker; A H Bom; Jan P C Heiligers; Pieter D Verdouw
Effects of MDL 72222 and methiothepin on carotid vascular responses to 5-hydroxytryptamine in the pig: evidence for the presence of "5-hydroxytryptamine1-like" receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1986;333(3):198-204.