FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Frances Ashcroft

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Physiology

Co-author Network

Publications

TOP 3
Constantina Fotinou; Ange Polidori; Bernard Pucci; Mark S P Sansom; Catherine Vénien-Bryan; Jussi Aittoniemi; Heidi de Wet; Frances M Ashcroft
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.
James S McTaggart; John-Stuart Brittain; Siri A W Greeley; Andrew T Hattersley; Kalai Arasu Muthusamy; Frances M Ashcroft
Gain-of-Function Mutations in the KATP Channel (KCNJ11) Impair Coordinated Hand-Eye Tracking.
Nellie Y Loh; Sian E Piret; Michael J Stechman; Paolo Tammaro; Sjoerd Verkaart; Bushra N Ahmad; Frances M Ashcroft; Ilaria Bellantuono; Liz Bentley; René J M Bindels; Steve D M Brown; Roger D Cox; Henrik Dimke; Holly Evans; William D Fraser; Caroline M Gorvin; Fadil M Hannan; Joost G J Hoenderop; Tertius A Hough; Rajesh V Thakker
Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Frances Ashcroft (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Constantina Fotinou; Ange Polidori; Bernard Pucci; Mark S P Sansom; Catherine Vénien-Bryan; Jussi Aittoniemi; Heidi de Wet; Frances M Ashcroft
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.
The FEBS journal 2013;280(4):1051-63.
2013: James S McTaggart; John-Stuart Brittain; Siri A W Greeley; Andrew T Hattersley; Kalai Arasu Muthusamy; Frances M Ashcroft
Gain-of-Function Mutations in the KATP Channel (KCNJ11) Impair Coordinated Hand-Eye Tracking.
PloS one 2013;8(4):e62646.
2013: Nellie Y Loh; Sian E Piret; Michael J Stechman; Paolo Tammaro; Sjoerd Verkaart; Bushra N Ahmad; Frances M Ashcroft; Ilaria Bellantuono; Liz Bentley; René J M Bindels; Steve D M Brown; Roger D Cox; Henrik Dimke; Holly Evans; William D Fraser; Caroline M Gorvin; Fadil M Hannan; Joost G J Hoenderop; Tertius A Hough; Rajesh V Thakker
Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.
PloS one 2013;8(1):e55412.
2012: Heidi de Wet; Mathilde Lafond; Mark S P Sansom; Kenju Shimomura; Nawaz Ahmad; Jussi Aittoniemi; Frances M Ashcroft
A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.
The Journal of physiology 2012;590(Pt 20):5025-36.
2012: Frances M Ashcroft; Patrik Rorsman
Diabetes mellitus and the β cell: the last ten years.
Cell 2012;148(6):1160-71.
2011: Roope Männikkö; Mark S P Sansom; Phillip J Stansfeld; Alexandra S Ashcroft; Sian Ellard; Andrew T Hattersley; Frances M Ashcroft
A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.
The Journal of physiology 2011;589(Pt 13):3071-83.
2011: James S McTaggart; Chris Church; Roger D Cox; Michaela Iberl; Sheena Lee; Frances M Ashcroft
FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.
PloS one 2011;6(11):e27968.
2010: Peter Proks; Heidi de Wet; Frances M Ashcroft
Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.
The Journal of general physiology 2010;136(4):389-405.
2010: James S McTaggart; Rebecca H Clark; Frances M Ashcroft
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.
The Journal of physiology 2010;588(Pt 17):3201-9.
2010: Rebecca H Clark; James S McTaggart; Richard Webster; Roope Mannikko; Michaela Iberl; Xiu Li Sim; Patrik Rorsman; Maike Glitsch; David Beeson; Frances M Ashcroft
Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin.
Science (New York, N.Y.) 2010;329(5990):458-61.
2010: Heidi de Wet; Constantina Fotinou; Nawaz Amad; Matthias Dreger; Frances M Ashcroft
The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids.
The FEBS journal 2010;277(12):2654-62.
2010: Jussi Aittoniemi; Heidi de Wet; Frances M Ashcroft; Mark S P Sansom
Asymmetric switching in a homodimeric ABC transporter: a simulation study.
PLoS computational biology 2010;6(4):e1000762.
2010: Frances M Ashcroft
New uses for old drugs: neonatal diabetes and sulphonylureas.
Cell metabolism 2010;11(3):179-81.
2010: Kenju Shimomura; G P de Nanclares; C Foutinou; M Caimari; L Castaño; Frances M Ashcroft
The first clinical case of a mutation at residue K185 of Kir6.2 (KCNJ11): a major ATP-binding residue.
Diabetic medicine : a journal of the British Diabetic Association 2010;27(2):225-9.
2010: Anita A C Reed; Nellie Y Loh; Sara Terryn; Jonathan D Lippiat; Chris Partridge; Juris Galvanovskis; Siân E Williams; Francois Jouret; Fiona T F Wu; Pierre J Courtoy; M Andrew Nesbit; Patrik Rorsman; Olivier Devuyst; Frances M Ashcroft; Rajesh V Thakker
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
American journal of physiology. Renal physiology 2010;298(2):F365-80.
2009: Michael B Hoppa; Stephan Collins; Reshma Ramracheya; Leanne Hodson; Stefan Amisten; Quan Zhang; Paul Johnson; Frances M Ashcroft; Patrik Rorsman
Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.
Cell metabolism 2009;10(6):455-65.
2009: Phillip J Stansfeld; Richard Hopkinson; Frances M Ashcroft; Mark S P Sansom
PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.
Biochemistry 2009;48(46):10926-33.
2009: Tim J Craig; Kenju Shimomura; Reinhard W Holl; Sarah E Flanagan; Sian Ellard; Frances M Ashcroft
An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.
The Journal of clinical endocrinology and metabolism 2009;94(7):2551-7.
2009: Kenju Shimomura; Sarah E Flanagan; Brittany Zadek; Mark Lethby; Lejla Zubcevic; Christophe A J Girard; Oliver Petz; Roope Mannikko; Ritika R Kapoor; Khalid Hussain; Mars Skae; Peter Clayton; Andrew Hattersley; Sian Ellard; Frances M Ashcroft
Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism.
EMBO molecular medicine 2009;1(3):166-77.
2009: Paolo Tammaro; Frances M Ashcroft
A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1.
The Journal of physiology 2009;587(Pt 8):1649-56.
2009: Christophe A Girard; F Thomas Wunderlich; Kenju Shimomura; Stephan Collins; Stephan Kaizik; Peter Proks; Fernando Abdulkader; Anne Clark; Vicky Ball; Lejla Zubcevic; Liz Bentley; Rebecca Clark; Chris Church; Alison Hugill; Juris Galvanovskis; Roger Cox; Patrik Rorsman; Jens C Brüning; Frances M Ashcroft
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
The Journal of clinical investigation 2009;119(1):80-90.
2009: Peter Proks; Frances M Ashcroft
Modeling K(ATP) channel gating and its regulation.
Progress in biophysics and molecular biology 2009;99(1):7-19.
2008: Jens Zehetner; Carsten Danzer; Stephan Collins; Katrin Eckhardt; Philipp A Gerber; Pia Ballschmieter; Juris Galvanovskis; Kenju Shimomura; Frances M Ashcroft; Bernard Thorens; Patrik Rorsman; Wilhelm Krek
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
Genes & development 2008;22(22):3135-46.
2008: Michelle Goldsworthy; Alison Hugill; Helen Freeman; Emma Horner; Kenju Shimomura; Debora Bogani; Guido Pieles; Vesna Mijat; Ruth Arkell; Shoumo Bhattacharya; Frances M Ashcroft; Roger D Cox
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.
Diabetes 2008;57(8):2234-44.
2008: Xiaosong Ma; Lejla Zubcevic; Frances M Ashcroft
Glucose regulates the effects of leptin on hypothalamic POMC neurons.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9811-6.
2008: Tim J Craig; Frances M Ashcroft; Peter Proks
How ATP inhibits the open K(ATP) channel.
The Journal of general physiology 2008;132(1):131-44.
2008: Heidi de Wet; Peter Proks; Mathilde Lafond; Jussi Aittoniemi; Mark S P Sansom; Sarah Flanagan; Ewan R Pearson; Andrew T Hattersley; Frances M Ashcroft
A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.
EMBO reports 2008;9(7):648-54.
2008: Paolo Tammaro; Sarah Flanagan; B Zadek; S Srinivasan; H Woodhead; S Hameed; Iwar Klimes; A T Hattersley; Sian Ellard; Frances M Ashcroft
A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications.
Diabetologia 2008;51(5):802-10.
2008: Julian P H Shield; Sarah Flanagan; Deborah J G Mackay; Lorna W Harries; Peter Proks; Christophe Girard; Frances M Ashcroft; I Karen Temple; Sian Ellard
Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy.
Diabetes 2008;57(1):255-8.
2007: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Science (New York, N.Y.) 2007;318(5855):1469-72.
2007: Heidi de Wet; Mathew G Rees; Kenju Shimomura; Jussi Aittoniemi; Ann-Marie Patch; Sarah Flanagan; Sian Ellard; Andrew T Hattersley; Mark S P Sansom; Frances M Ashcroft
Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):18988-92.
2007: Szymon Jarosławski; Brittany Zadek; Frances M Ashcroft; Catherine Vénien-Bryan; Simon Scheuring
Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy.
Journal of molecular biology 2007;374(2):500-5.
2007: Andrei I Tarasov; Christophe Girard; Brian Larkin; Paolo Tammaro; Sarah Flanagan; Sian Ellard; Frances M Ashcroft
Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes.
Diabetes, obesity & metabolism 2007;9 Suppl 2():46-55.
2007: Paolo Tammaro; Frances M Ashcroft
A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
The Journal of physiology 2007;584(Pt 3):743-53.
2007: Kenju Shimomura; Friederike Hörster; Heidi de Wet; Sarah Flanagan; Sian Ellard; Andrew T Hattersley; Nicole I Wolf; Frances M Ashcroft; Friedrich Ebinger
A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.
Neurology 2007;69(13):1342-9.
2007: haider shozeb; Andrei I Tarasov; Tim J Craig; Mark S P Sansom; Frances M Ashcroft
Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.
The EMBO journal 2007;26(16):3749-59.
2007: Peter Proks; Kenju Shimomura; Tim J Craig; Christophe Girard; Frances M Ashcroft
Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.
Human molecular genetics 2007;16(16):2011-9.
2007: Sian Ellard; Sarah Flanagan; Christophe Girard; Ann-Marie Patch; Lorna W Harries; Andrew Parrish; Emma L Edghill; Deborah J G Mackay; Peter Proks; Kenju Shimomura; Holger Haberland; Dennis J Carson; Julian P H Shield; Andrew T Hattersley; Frances M Ashcroft
Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.
American journal of human genetics 2007;81(2):375-82.
2007: Xiaosong Ma; Jens Bruning; Frances M Ashcroft
Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(27):7125-9.
2007: Heidi de Wet; Michael V Mikhailov; Constantina Fotinou; Mathias Dreger; Tim J Craig; Catherine Vénien-Bryan; Frances M Ashcroft
Studies of the ATPase activity of the ABC protein SUR1.
The FEBS journal 2007;274(14):3532-44.
2007: Paolo Tammaro; Frances M Ashcroft
The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
The Journal of physiology 2007;581(Pt 3):1259-69.
2007: A Christine Könner; Ruth Janoschek; Leona Plum; Sabine D Jordan; Eva Rother; Xiaosong Ma; Chun Xu; Pablo J Enriori; Brigitte Hampel; Gregory S Barsh; C Ronald Kahn; Michael Alexander cowley; Frances M Ashcroft; Jens C Brüning
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
Cell metabolism 2007;5(6):438-49.
2007: Quan Zhang; Martin Bengtsson; Christopher J Partridge; Albert Salehi; Matthias Braun; Roger Cox; Lena Eliasson; Paul R V Johnson; Erik Renström; Toni Schneider; Per-Olof Berggren; Sven Göpel; Frances M Ashcroft; Patrik Rorsman
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
Nature cell biology 2007;9(4):453-60.
2007: haider shozeb; Syma Khalid; Stephen J Tucker; Frances M Ashcroft; Mark S P Sansom
Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
Biochemistry 2007;46(12):3643-52.
2007: Xiaosong Ma; Lejla Zubcevic; Jens C Brüning; Frances M Ashcroft; Denis Burdakov
Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(7):1529-33.
2006: Christophe Girard; Kenju Shimomura; Peter Proks; Nathan Absalom; Luis Castano; Guiomar Perez de Nanclares; Frances M Ashcroft
Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.
Pflügers Archiv : European journal of physiology 2006;453(3):323-32.
2006: Andrei I Tarasov; Hannah J Welters; Sabine Senkel; Gerhart U Ryffel; Andrew T Hattersley; Noel G Morgan; Frances M Ashcroft
A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.
Diabetes 2006;55(11):3075-82.
2006: Helen Freeman; Kenju Shimomura; Roger D Cox; Frances M Ashcroft
Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.
Biochemical Society transactions 2006;34(Pt 5):806-10.
2006: Andrei I Tarasov; Christophe Girard; Frances M Ashcroft
ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.
Diabetes 2006;55(9):2446-54.
2006: Ewan R Pearson; Isabelle Flechtner; Pål R Njølstad; Maciej T Malecki; Sarah Flanagan; Brian Larkin; Frances M Ashcroft; Iwar Klimes; Ethel Codner; Violeta Iotova; Annabelle S Slingerland; Julian P H Shield; Jean-Jacques Robert; Jens J Holst; Penny M Clark; Sian Ellard; Oddmund Søvik; Michel Polak; Andrew T Hattersley
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
The New England journal of medicine 2006;355(5):467-77.
2006: Helen C Freeman; Alison Hugill; Neil T Dear; Frances M Ashcroft; Roger D Cox
Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice.
Diabetes 2006;55(7):2153-6.
2006: Leona Plum; Xiaosong Ma; Brigitte Hampel; Nina Balthasar; Roberto Coppari; Heike Münzberg; Marya Shanabrough; Denis Burdakov; Eva Rother; Ruth Janoschek; Jens Alber; Bengt F Belgardt; Linda Koch; Jost Seibler; Frieder Schwenk; Csaba Fekete; Akira Suzuki; Tak W Mak; Wilhelm Krone; Tamas L Horvath; Frances M Ashcroft; Jens C Brüning
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.
The Journal of clinical investigation 2006;116(7):1886-901.
2006: Peter Proks; Christophe Girard; Halvor Baevre; Pål R Njølstad; Frances M Ashcroft
Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.
Diabetes 2006;55(6):1731-7.
2006: Kenju Shimomura; Christophe Girard; Peter Proks; Joanna Nazim; Jonathan D Lippiat; Franco Cerutti; Renata Lorini; Sian Ellard; Andrew T Hattersley; Fabrizio Barbetti; Frances M Ashcroft
Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.
Diabetes 2006;55(6):1705-12.
2006: Peter Proks; Amanda L Arnold; Jan Bruining; Christophe Girard; Sarah Flanagan; Brian Larkin; Kevin Colclough; Andrew T Hattersley; Frances M Ashcroft; Sian Ellard
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.
Human molecular genetics 2006;15(11):1793-800.
2006: Robert M J Deacon; R C Brook; D Meyer; O Haeckel; Frances M Ashcroft; Takashi Miki; Susumu Seino; Birgit Liss
Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
Physiology & behavior 2006;87(4):723-33.
2006: Frances M Ashcroft
K(ATP) channels and insulin secretion: a key role in health and disease.
Biochemical Society transactions 2006;34(Pt 2):243-6.
2006: Frances M Ashcroft
From molecule to malady.
Nature 2006;440(7083):440-7.
2006: Paolo Tammaro; Peter Proks; Frances M Ashcroft
Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.
The Journal of physiology 2006;571(Pt 1):3-14.
2006: Helen Freeman; Kenju Shimomura; Emma Horner; Roger D Cox; Frances M Ashcroft
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
Cell metabolism 2006;3(1):35-45.
2005: Michael V Mikhailov; Jeff D Campbell; Heidi de Wet; Kenju Shimomura; Brittany Zadek; Richard F Collins; Mark S P Sansom; Robert C Ford; Frances M Ashcroft
3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.
The EMBO journal 2005;24(23):4166-75.
2005: Peter Proks; Christophe Girard; Frances M Ashcroft
Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.
Human molecular genetics 2005;14(18):2717-26.
2005: Andrew T Hattersley; Frances M Ashcroft
Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy.
Diabetes 2005;54(9):2503-13.
2005: Frances M Ashcroft
ATP-sensitive potassium channelopathies: focus on insulin secretion.
The Journal of clinical investigation 2005;115(8):2047-58.
2005: Paolo Tammaro; Christophe Girard; Janne Molnes; Pål R Njølstad; Frances M Ashcroft
Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.
The EMBO journal 2005;24(13):2318-30.
2005: haider shozeb; Jennifer F Antcliff; Peter Proks; Mark S P Sansom; Frances M Ashcroft
Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
Journal of molecular and cellular cardiology 2005;38(6):927-36.
2005: Peter Proks; Christophe Girard; haider shozeb; Anna L Gloyn; Andrew T Hattersley; Mark S P Sansom; Frances M Ashcroft
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.
EMBO reports 2005;6(5):470-5.
2005: haider shozeb; Alessandro Grottesi; Benjamin Andrew Hall; Frances M Ashcroft; Mark S P Sansom
Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.
Biophysical journal 2005;88(5):3310-20.
2005: Ayo TOYE; Jonathan D Lippiat; Peter Proks; Kenju Shimomura; Liz Bentley; Alison Hugill; V Mijat; Michelle Goldsworthy; Lee Moir; Alison Haynes; J Quarterman; H C Freeman; Frances M Ashcroft; Roger D Cox
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
Diabetologia 2005;48(4):675-86.
2005: Anna L Gloyn; Frank Reimann; Christophe Girard; Emma L Edghill; Peter Proks; Ewan R Pearson; I Karen Temple; Deborah J G Mackay; Julian P H Shield; Debra Freedenberg; Kathryn Noyes; Sian Ellard; Frances M Ashcroft; Fiona M Gribble; Andrew T Hattersley
Relapsing diabetes can result from moderately activating mutations in KCNJ11.
Human molecular genetics 2005;14(7):925-34.
2005: Jennifer F Antcliff; haider shozeb; Peter Proks; Mark S P Sansom; Frances M Ashcroft
Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
The EMBO journal 2005;24(2):229-39.
2004: Peter Proks; Jennifer F Antcliff; Jonathan D Lippiat; Anna L Gloyn; Andrew T Hattersley; Frances M Ashcroft
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17539-44.
2004: Denis Burdakov; Haris Alexopoulos; Angela Vincent; Frances M Ashcroft
Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons.
The European journal of neuroscience 2004;20(12):3281-5.
2004: Jeff D Campbell; Peter Proks; Jonathan D Lippiat; Mark S P Sansom; Frances M Ashcroft
Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.
Diabetes 2004;53 Suppl 3():S123-7.
2004: Jeff D Campbell; Sundeep S Deol; Frances M Ashcroft; Ian D Kerr; Mark S P Sansom
Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain.
Biophysical journal 2004;87(6):3703-15.
2004: Michael Dabrowski; Andrei Tarasov; Frances M Ashcroft
Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
The Journal of physiology 2004;557(Pt 2):347-54.
2004: Frances M Ashcroft; Patrik Rorsman
Molecular defects in insulin secretion in type-2 diabetes.
Reviews in endocrine & metabolic disorders 2004;5(2):135-42.
2004: Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; J K H Wales; Penny Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
The New England journal of medicine 2004;350(18):1838-49.
2004: Frances M Ashcroft; Patrik Rorsman
Type 2 diabetes mellitus: not quite exciting enough?
Human molecular genetics 2004;13 Spec No 1():R21-31.
2004: Takashi Tsuboi; Jonathan D Lippiat; Frances M Ashcroft; Guy A Rutter
ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):76-81.
2003: Jeff D Campbell; Mark S P Sansom; Frances M Ashcroft
Potassium channel regulation.
EMBO reports 2003;4(11):1038-42.
2003: Michael Dabrowski; T Larsen; Frances M Ashcroft; John Bondo Hansen; Philip Wahl
Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.
Diabetologia 2003;46(10):1375-82.
2003: Michael Dabrowski; Stefan Trapp; Frances M Ashcroft
Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.
The Journal of physiology 2003;550(Pt 2):357-63.
2003: Anling Kuo; Jacqueline M Gulbis; Jennifer F Antcliff; Tahmina Rahman; Edward D Lowe; Jochen Zimmer; Jonathan M Cuthbertson; Frances M Ashcroft; Takayuki Ezaki; Declan Doyle
Crystal structure of the potassium channel KirBac1.1 in the closed state.
Science (New York, N.Y.) 2003;300(5627):1922-6.
2003: Stefan Trapp; haider shozeb; Phillippa Jones; Mark S P Sansom; Frances M Ashcroft
Identification of residues contributing to the ATP binding site of Kir6.2.
The EMBO journal 2003;22(12):2903-12.
2003: Denis Burdakov; Birgit Liss; Frances M Ashcroft
Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(12):4951-7.
2003: Charlotte E Capener; Peter Proks; Frances M Ashcroft; Mark S P Sansom
Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
Biophysical journal 2003;84(4):2345-56.
2003: Frank Reimann; Michael Dabrowski; Phillippa Jones; Fiona M Gribble; Frances M Ashcroft
Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
The Journal of physiology 2003;547(Pt 1):159-68.
2003: Frank Reimann; Hanna Huopio; Michael Dabrowski; Peter Proks; Fiona M Gribble; Markku Laakso; Timo Otonkoski; Frances M Ashcroft
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.
Diabetologia 2003;46(2):241-9.
2003: Hanna Huopio; Timo Otonkoski; Ilkka Vauhkonen; Frank Reimann; Frances M Ashcroft; Markku Laakso
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
Lancet 2003;361(9354):301-7.
2003: Peter Proks; Jennifer F Antcliff; Frances M Ashcroft
The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.
EMBO reports 2003;4(1):70-5.
2002: Jonathan D Lippiat; Sophie L Albinson; Frances M Ashcroft
Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
Diabetes 2002;51 Suppl 3():S377-80.
2002: Peter Proks; Frank Reimann; Nick Green; Fiona M Gribble; Frances M Ashcroft
Sulfonylurea stimulation of insulin secretion.
Diabetes 2002;51 Suppl 3():S368-76.
2002: Denis Burdakov; Frances M Ashcroft
Shedding new light on brain metabolism and glial function.
The Journal of physiology 2002;544(Pt 2):334.
2002: Ann Maria K Hansen; Inge T Christensen; John Bondo Hansen; Richard D Carr; Frances M Ashcroft; Philip Wahl
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1.
Diabetes 2002;51(9):2789-95.
2002: Michinori Matsuo; Michael Dabrowski; Kazumitsu Ueda; Frances M Ashcroft
Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding.
The EMBO journal 2002;21(16):4250-8.
2002: Denis Burdakov; Frances M Ashcroft
Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6380-7.
2002: Michael Dabrowski; Frances M Ashcroft; Rebecca Ashfield; Philippe Lebrun; Bernard Pirotte; Jan Egebjerg; John Bondo Hansen; Philip Wahl
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.
Diabetes 2002;51(6):1896-906.
2001: P A Jones; Stephen J Tucker; Frances M Ashcroft
Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
FEBS letters 2001;508(1):85-9.
2001: Peter Proks; Charlotte E Capener; P Jones; Frances M Ashcroft
Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.
The Journal of general physiology 2001;118(4):341-53.
2001: Gildas Loussouarn; L J Pike; Frances M Ashcroft; EN Makhina; Colin G Nichols
Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.
The Journal of biological chemistry 2001;276(31):29098-103.
2001: M Dabrowski; P Wahl; W E Holmes; Frances M Ashcroft
Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels.
Diabetologia 2001;44(6):747-56.
2001: Takashi Miki; Birgit Liss; Kohtaro Minami; Tetsuya Shiuchi; Atsunori Saraya; Y Kashima; M Horiuchi; Frances M Ashcroft; Yasuhiko Minokoshi; Jochen Roeper; Susumu Seino
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.
Nature neuroscience 2001;4(5):507-12.
2001: Frank Reimann; Peter Proks; Frances M Ashcroft
Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
British journal of pharmacology 2001;132(7):1542-8.
2001: D K Song; Frances M Ashcroft
ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.
The Journal of biological chemistry 2001;276(10):7143-9.
2001: Peter Proks; Phillippa Jones; Frances M Ashcroft
Interaction of stilbene disulphonates with cloned K(ATP) channels.
British journal of pharmacology 2001;132(5):973-82.
2000: Frank Reimann; Fiona M Gribble; Frances M Ashcroft
Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.
Molecular pharmacology 2000;58(6):1318-25.
2000: Frances M Ashcroft; Fiona M Gribble
New windows on the mechanism of action of K(ATP) channel openers.
Trends in pharmacological sciences 2000;21(11):439-45.
2000: S Trapp; Frances M Ashcroft
Direct interaction of Na-azide with the KATP channel.
British journal of pharmacology 2000;131(6):1105-12.
2000: Frances M Ashcroft
The Yin and Yang of the K(ATP) channel.
The Journal of physiology 2000;528(Pt 3):405.
2000: Fiona M Gribble; T M Davis; C E Higham; A Clark; Frances M Ashcroft
The antimalarial agent mefloquine inhibits ATP-sensitive K-channels.
British journal of pharmacology 2000;131(4):756-60.
2000: Hanna Huopio; Frank Reimann; R Ashfield; Jorma Komulainen; H L Lenko; Jacques Rahier; Ilkka Vauhkonen; Juha Kere; Markku Laakso; Frances M Ashcroft; Timo Otonkoski
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.
The Journal of clinical investigation 2000;106(7):897-906.
2000: Fiona M Gribble; Gildas Loussouarn; Stephen J Tucker; C Zhao; Colin G Nichols; Frances M Ashcroft
A novel method for measurement of submembrane ATP concentration.
The Journal of biological chemistry 2000;275(39):30046-9.
2000: Frances M Ashcroft; Fiona M Gribble
Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.
Journal of diabetes and its complications 2000;14(4):192-6.
2000: Fiona M Gribble; Frank Reimann; R Ashfield; Frances M Ashcroft
Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.
Molecular pharmacology 2000;57(6):1256-61.
1999: P A Smith; P Proks; Frances M Ashcroft
Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells.
The Journal of physiology 1999;521 Pt 3():651-64.
1999: H Sakura; Stefan Trapp; B Liss; Frances M Ashcroft
Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.
The Journal of physiology 1999;521 Pt 2():337-50.
1999: Stephen J Tucker; Frances M Ashcroft
Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
The Journal of biological chemistry 1999;274(47):33393-7.
1999: Frank Reimann; T J Ryder; Stephen J Tucker; Frances M Ashcroft
The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
The Journal of physiology 1999;520 Pt 3():661-9.
1999: Peter Proks; R Ashfield; Frances M Ashcroft
Interaction of vanadate with the cloned beta cell K(ATP) channel.
The Journal of biological chemistry 1999;274(36):25393-7.
1999: Frances M Ashcroft; Fiona M Gribble
ATP-sensitive K+ channels and insulin secretion: their role in health and disease.
Diabetologia 1999;42(8):903-19.
1999: Frank Reimann; Frances M Ashcroft
Inwardly rectifying potassium channels.
Current opinion in cell biology 1999;11(4):503-8.
1999: Frank Reimann; Stephen J Tucker; Peter Proks; Frances M Ashcroft
Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
The Journal of physiology 1999;518 ( Pt 2)():325-36.
1999: Fiona M Gribble; Frances M Ashcroft
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
Diabetologia 1999;42(7):845-8.
1999: R Ashfield; Fiona M Gribble; Stephen J H Ashcroft; Frances M Ashcroft
Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.
Diabetes 1999;48(6):1341-7.
1999: Timo Otonkoski; C Ammälä; Hanna Huopio; Gilbert J Cote; J Chapman; Karen E Cosgrove; R Ashfield; E Huang; Jorma Komulainen; Frances M Ashcroft; Mark J Dunne; Juha Kere; Pamela M Thomas
A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland.
Diabetes 1999;48(2):408-15.
1999: Peter Proks; Fiona M Gribble; R Adhikari; Stephen J Tucker; Frances M Ashcroft
Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
The Journal of physiology 1999;514 ( Pt 1)():19-25.
1998: Frances M Ashcroft
Exciting times for PIP2.
Science (New York, N.Y.) 1998;282(5391):1059-60.
1998: Fiona M Gribble; Peter Proks; Barbara E Corkey; Frances M Ashcroft
Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.
The Journal of biological chemistry 1998;273(41):26383-7.
1998: Fiona M Gribble; Stephen J Tucker; S Seino; Frances M Ashcroft
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.
Diabetes 1998;47(9):1412-8.
1998: Stefan Trapp; Peter Proks; Stephen J Tucker; Frances M Ashcroft
Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
The Journal of general physiology 1998;112(3):333-49.
1998: Stefan Trapp; Stephen J Tucker; Frances M Ashcroft
Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.
The Journal of general physiology 1998;112(3):325-32.
1998: Michael V Mikhailov; P Proks; Frances M Ashcroft; Stephen J H Ashcroft
Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.
FEBS letters 1998;429(3):390-4.
1998: Stephen J Tucker; Fiona M Gribble; Peter Proks; Stefan Trapp; T J Ryder; T Haug; Frank Reimann; Frances M Ashcroft
Molecular determinants of KATP channel inhibition by ATP.
The EMBO journal 1998;17(12):3290-6.
1998: Fiona M Gribble; Stephen J Tucker; T Haug; Frances M Ashcroft
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7185-90.
1998: Stephen J Tucker; Frances M Ashcroft
A touching case of channel regulation: the ATP-sensitive K+ channel.
Current opinion in neurobiology 1998;8(3):316-20.
1998: H Sakura; S J Ashcroft; Y Terauchi; T Kadowaki; Frances M Ashcroft
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Diabetologia 1998;41(6):654-9.
1997: Peter Proks; Frances M Ashcroft
Phentolamine block of KATP channels is mediated by Kir6.2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11716-20.
1997: Fiona M Gribble; Stephen J Tucker; Frances M Ashcroft
The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.
The Journal of physiology 1997;504 ( Pt 1)():35-45.
1997: S Trapp; Stephen J Tucker; Frances M Ashcroft
Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8872-7.
1997: Stephen J Tucker; Fiona M Gribble; C Zhao; Stefan Trapp; Frances M Ashcroft
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
Nature 1997;387(6629):179-83.
1997: H Sakura; Frances M Ashcroft
Identification of four trp1 gene variants murine pancreatic beta-cells.
Diabetologia 1997;40(5):528-32.
1997: Fiona M Gribble; Stephen J Tucker; Frances M Ashcroft
The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.
The EMBO journal 1997;16(6):1145-52.
1997: P A Smith; H Sakura; B Coles; Nigel Gummerson; P Proks; Frances M Ashcroft
Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells.
The Journal of physiology 1997;499 ( Pt 3)():625-35.
1997: M Faehling; Frances M Ashcroft
Heterogeneity of beta-cell secretion. Possible involvement of K-ATP channels.
Advances in experimental medicine and biology 1997;426():247-52.
1997: I Niki; B Coles; Frances M Ashcroft; Stephen J H Ashcroft
Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell.
Advances in experimental medicine and biology 1997;426():59-69.
1997: Fiona M Gribble; R Ashfield; C Ammälä; Frances M Ashcroft
Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.
The Journal of physiology 1997;498 ( Pt 1)():87-98.