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Mark Heiman

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F Craig Stevens; William E Bloomquist; Anthony G Borel; Marlene L Cohen; Christine A Droste; Mark L Heiman; Aidas Kriauciunas; Daniel J Sall; Frank C Tinsley; Cynthia D Jesudason
Potent oxindole based human beta3 adrenergic receptor agonists.
Guillaume Gourcerol; Tamer Coskun; Libbey S Craft; John P Mayer; Mark L Heiman; Lixin Wang; Mulugeta Million; David H St-Pierre; Yvette Taché
Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents.
Liang Zeng Yan; Hansen M Hsiung; Mark L Heiman; Robert A Gadski; Paul J Emmerson; JeAnne Hertel; David B Flora; Patrick Edwards; David L Smiley; Lianshan Zhang; Saba Husain; Steven D Kahl; Richard D Dimarchi; John P Mayer
Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

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2007: F Craig Stevens; William E Bloomquist; Anthony G Borel; Marlene L Cohen; Christine A Droste; Mark L Heiman; Aidas Kriauciunas; Daniel J Sall; Frank C Tinsley; Cynthia D Jesudason
Potent oxindole based human beta3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 2007;17(22):6270-3.
2007: Guillaume Gourcerol; Tamer Coskun; Libbey S Craft; John P Mayer; Mark L Heiman; Lixin Wang; Mulugeta Million; David H St-Pierre; Yvette Taché
Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents.
Obesity (Silver Spring, Md.) 2007;15(11):2643-52.
2007: Liang Zeng Yan; Hansen M Hsiung; Mark L Heiman; Robert A Gadski; Paul J Emmerson; JeAnne Hertel; David B Flora; Patrick Edwards; David L Smiley; Lianshan Zhang; Saba Husain; Steven D Kahl; Richard D Dimarchi; John P Mayer
Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.
Current topics in medicinal chemistry 2007;7(11):1052-67.
2006: Don R Finley; Michael G Bell; Anthony G Borel; William E Bloomquist; Marlene L Cohen; Mark L Heiman; Aidas Kriauciunas; Donald P Matthews; Tania Miles; David A Neel; Christopher J Rito; Daniel J Sall; Anthony J Shuker; Thomas W Stephens; Frank C Tinsley; Mark A Winter; Cynthia D Jesudason
Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 2006;16(21):5691-4.
2005: Hansen M Hsiung; JeAnne Hertel; Xing-Yue Zhang; Dennis P Smith; David L Smiley; Mark L Heiman; Derek D Yang; Saba Husain; John P Mayer; Lianshan Zhang; Huaping Mo; Liang Zeng Yan
A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.
Endocrinology 2005;146(12):5257-66.
2005: Liang Zeng Yan; David B Flora; Patrick Edwards; David L Smiley; Paul J Emmerson; Hansen M Hsiung; Robert A Gadski; JeAnne Hertel; Mark L Heiman; Saba Husain; Thomas P O'Brien; Steven D Kahl; Lianshan Zhang; Richard D Dimarchi; John P Mayer
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.
Bioorganic & medicinal chemistry letters 2005;15(20):4611-4.
2005: Hansen M Hsiung; David L Smiley; Xing-yue Zhang; Lianshan Zhang; Liang Zeng Yan; Libbey Craft; Mark L Heiman; Dennis P Smith
Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV.
Peptides 2005;26(10):1988-96.
2005: John P Mayer; Hansen M Hsiung; David B Flora; Patrick Edwards; Dennis P Smith; Xing-Yue Zhang; Robert A Gadski; Mark L Heiman; JeAnne Hertel; Paul J Emmerson; Saba Husain; Thomas P O'Brien; Steven D Kahl; David L Smiley; Lianshan Zhang; Richard D Dimarchi; Liang Zeng Yan
Discovery of a beta-MSH-derived MC-4R selective agonist.
Journal of medicinal chemistry 2005;48(9):3095-8.
2004: Charles W Lugar; Michael P Clay; Terry D Lindstrom; Andrea L Woodson; David L Smiley; Mark L Heiman; Jeffrey A Dodge
Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats.
Bioorganic & medicinal chemistry letters 2004;14(23):5873-6.
2004: Karen L Teff; Sharon S Elliott; Matthias H Tschöp; Timothy J Kieffer; Daniel J Rader; Mark L Heiman; Raymond R Townsend; Nancy L Keim; David A D'Alessio; Peter J Havel
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
The Journal of clinical endocrinology and metabolism 2004;89(6):2963-72.
2004: Aart Jan Van der Lely; Matthias H Tschöp; Mark L Heiman; Ezio Ghigo
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
Endocrine reviews 2004;25(3):426-57.
2004: Frank C Tinsley; Gersh Z Taicher; Mark L Heiman
Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.
Obesity research 2004;12(1):150-60.
2003: Mark L Heiman; Michael A Statnick
Galanin-like peptide functions more like leptin than like galanin.
Endocrinology 2003;144(11):4707-8.
2003: Gersh Z Taicher; Frank C Tinsley; Arcady Reiderman; Mark L Heiman
Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis.
Analytical and bioanalytical chemistry 2003;377(6):990-1002.
2003: Michael A Statnick; Frank C Tinsley; Brian J Eastwood; Todd M Suter; Charles H Mitch; Mark L Heiman
Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(6):R1399-408.
2003: Michael Alexander cowley; Roy G Smith; Sabrina Diano; Matthias H Tschöp; Nina Pronchuk; Kevin L Grove; Christian J Strasburger; Martin Bidlingmaier; Michael Esterman; Mark L Heiman; Luis M Garcia-Segura; Eduardo A Nillni; Pablo Mendez; Malcolm J Low; Peter Sotonyi; Jeffrey M Friedman; Hongyan Liu; Shirly Pinto; William F Colmers; Roger D Cone; Tamas L Horvath
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.
Neuron 2003;37(4):649-61.
2003: Mark L Heiman; Frank C Tinsley; Julie A Mattison; Steven Hauck; Andrzej Bartke
Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice.
Endocrine 2003;20(1-2):149-54.
2002: Uberto Pagotto; Alessandra Gambineri; Valentina Vicennati; Mark L Heiman; Matthias H Tschöp; Renato Pasquali
Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels.
The Journal of clinical endocrinology and metabolism 2002;87(12):5625-9.
2002: Angelo DelParigi; Matthias H Tschöp; Mark L Heiman; Arline D Salbe; Barbora Vozarova; Susan M Sell; Joy C Bunt; P Antonio Tataranni
High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(12):5461-4.
2002: Matthias H Tschöp; David B Flora; John P Mayer; Mark L Heiman
Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats.
Obesity research 2002;10(10):991-9.
2002: Mark Asnicar; Anja Köster; Mark L Heiman; Frank Tinsley; Dennis P Smith; Elizabeth Galbreath; Niles Fox; Yanfei L Ma; Werner Blum; Hansen M Hsiung
Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate.
Endocrinology 2002;143(10):3994-4006.
2002: Olavi Ukkola; Eric Ravussin; Peter Jacobson; Louis Pérusse; Tuomo Rankinen; Matthias H Tschöp; Mark L Heiman; Arthur S Leon; Dabeeru C Rao; James Skinner; Jack H Wilmore; Lars Sjöström; Claude Bouchard
Role of ghrelin polymorphisms in obesity based on three different studies.
Obesity research 2002;10(8):782-91.
2002: William A Banks; Matthias H Tschöp; Sandra M Robinson; Mark L Heiman
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure.
The Journal of pharmacology and experimental therapeutics 2002;302(2):822-7.
2002: Yanyun Chen; Changzhi Hu; Chiun-Kang Hsu; Qing Zhang; Chen Bi; Mark Asnicar; Hansen M Hsiung; Niles Fox; Lawrence J Slieker; Derek D Yang; Mark L Heiman; Yuguang Shi
Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.
Endocrinology 2002;143(7):2469-77.
2002: Giampiero Muccioli; Matthias H Tschöp; Mauro Papotti; Romano Deghenghi; Mark L Heiman; Ezio Ghigo
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity.
European journal of pharmacology 2002;440(2-3):235-54.
2002: Matthias H Tschöp; Mark L Heiman
Overview of rodent models for obesity research.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2002;Chapter 9():Unit 9.10.
2002: F Rohner-Jeanrenaud; Libbey Craft; J Bridwell; Todd M Suter; F C Tinsley; David L Smiley; D R Burkhart; Michael A Statnick; Mark L Heiman; E Ravussin; JF Caro
Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(2):143-9.
2002: Matthias H Tschöp; Michael A Statnick; Todd M Suter; Mark L Heiman
GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein.
Endocrinology 2002;143(2):558-68.
2001: Bärbel Otto; Ulrich Cuntz; E Fruehauf; Rainer Wawarta; Christian Folwaczny; Rudolf L Riepl; Mark L Heiman; Peter Lehnert; Manfred Fichter; Matthias H Tschöp
Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(5):669-73.
2001: Mark Asnicar; Dennis P Smith; Derek D Yang; Mark L Heiman; Niles Fox; Y F Chen; Hansen M Hsiung; Anja Köster
Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet.
Endocrinology 2001;142(10):4394-400.
2001: Tamas L Horvath; Sabrina Diano; Peter Sotonyi; Mark L Heiman; Matthias H Tschöp
Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective.
Endocrinology 2001;142(10):4163-9.
2001: Eric Ravussin; M Tschöp; S Morales; Claude Bouchard; Mark L Heiman
Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins.
The Journal of clinical endocrinology and metabolism 2001;86(9):4547-51.
2001: M Tschöp; C Weyer; P A Tataranni; V Devanarayan; E Ravussin; Mark L Heiman
Circulating ghrelin levels are decreased in human obesity.
Diabetes 2001;50(4):707-9.
2001: M Tschöp; Mark L Heiman
Rodent obesity models: an overview.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(6):307-19.
2000: M Tschöp; David L Smiley; Mark L Heiman
Ghrelin induces adiposity in rodents.
Nature 2000;407(6806):908-13.
2000: Jean-François Gautier; Kewie Chen; Arline D Salbe; Daniel Bandy; Richard E Pratley; Mark L Heiman; Eric Ravussin; Eric Reiman; P Antonio Tataranni
Differential brain responses to satiation in obese and lean men.
Diabetes 2000;49(5):838-46.
1998: KW Sloop; PL Surface; Mark L Heiman; Lawrence J Slieker
Changes in leptin expression are not associated with corresponding changes in CCAAT/enhancer binding protein-alpha.
Biochemical and biophysical research communications 1998;251(1):142-7.
1998: Hannu Koistinen; Juha A Tuominen; Pertti Ebeling; Mark L Heiman; T W Stephens; Veikko Koivisto
The effect of exercise on leptin concentration in healthy men and in type 1 diabetic patients.
Medicine and science in sports and exercise 1998;30(6):805-10.
1998: Michael Landt; RL Gingerich; Peter J Havel; WM Mueller; Brigitte E Schoner; John E Hale; Mark L Heiman
Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans.
Clinical chemistry 1998;44(3):565-70.
1997: Mark L Heiman; Rexford S Ahima; Libbey Craft; Brigitte E Schoner; T W Stephens; J S Flier
Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress.
Endocrinology 1997;138(9):3859-63.
1997: Juha A Tuominen; Pertti Ebeling; Mark L Heiman; T Stephens; Veikko Koivisto
Leptin and thermogenesis in humans.
Acta physiologica Scandinavica 1997;160(1):83-7.
1997: Juha A Tuominen; Pertti Ebeling; F W Laquier; Mark L Heiman; T Stephens; Veikko Koivisto
Serum leptin concentration and fuel homeostasis in healthy man.
European journal of clinical investigation 1997;27(3):206-11.
1997: Juha A Tuominen; Pertti Ebeling; Ulf-Hakan Stenman; Mark L Heiman; T W Stephens; Veikko Koivisto
Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes mellitus patients.
The Journal of clinical endocrinology and metabolism 1997;82(2):381-2.
1996: M K Sinha; J Sturis; J Ohannesian; S Magosin; T Stephens; Mark L Heiman; Kenneth S Polonsky; JF Caro
Ultradian oscillations of leptin secretion in humans.
Biochemical and biophysical research communications 1996;228(3):733-8.
1996: M K Sinha; Iryna L Opentanova; J P Ohannesian; JW Kolaczynski; Mark L Heiman; J Hale; Gerald Becker; R R Bowsher; T W Stephens; JF Caro
Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting.
The Journal of clinical investigation 1996;98(6):1277-82.
1996: M K Sinha; J P Ohannesian; Mark L Heiman; A Kriauciunas; T W Stephens; S Magosin; C Marco; JF Caro
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
The Journal of clinical investigation 1996;97(5):1344-7.
1996: RV Considine; M K Sinha; Mark L Heiman; A Kriauciunas; T W Stephens; M R Nyce; J P Ohannesian; C C Marco; L J McKee; T L Bauer
Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
The New England journal of medicine 1996;334(5):292-5.
1993: K Hannon; E Johnstone; L S Craft; Sheila P Little; C K Smith; Mark L Heiman; R F Santerre
Synthesis of PCR-derived, single-stranded DNA probes suitable for in situ hybridization.
Analytical biochemistry 1993;212(2):421-7.