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Robert Heine

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Daniël H van Raalte; Carolyn F Deacon; Robert J Heine; Jens J Holst; John M Karemaker; Kelly A A Kwa; Andrea Mari; Maarten E Tushuizen; Renate E van Genugten; Michaela Diamant
Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
Maarten E Tushuizen; Erik G Peypers; Augueste Sturk; Michaela Diamant; Robert J Heine; Frans J Hoek; Rienk Nieuwland
Postprandial changes in the phospholipid composition of circulating microparticles are not associated with coagulation activation.
Esther van 't Riet; Marjan Alssema; Robert J Heine; Giel Nijpels; Josina M Rijkelijkhuizen; Coen D A Stehouwer; Jacqueline M Dekker
HbA1c is an independent predictor of non-fatal cardiovascular disease in a Caucasian population without diabetes: a 10-year follow-up of the Hoorn Study.

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All Publications

2013: Daniël H van Raalte; Carolyn F Deacon; Robert J Heine; Jens J Holst; John M Karemaker; Kelly A A Kwa; Andrea Mari; Maarten E Tushuizen; Renate E van Genugten; Michaela Diamant
Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
Metabolism: clinical and experimental 2013;62(4):568-77.
2012: Maarten E Tushuizen; Erik G Peypers; Augueste Sturk; Michaela Diamant; Robert J Heine; Frans J Hoek; Rienk Nieuwland
Postprandial changes in the phospholipid composition of circulating microparticles are not associated with coagulation activation.
Thrombosis research 2012;130(1):115-21.
2012: Esther van 't Riet; Marjan Alssema; Robert J Heine; Giel Nijpels; Josina M Rijkelijkhuizen; Coen D A Stehouwer; Jacqueline M Dekker
HbA1c is an independent predictor of non-fatal cardiovascular disease in a Caucasian population without diabetes: a 10-year follow-up of the Hoorn Study.
European journal of preventive cardiology 2012;19(1):23-31.
2011: Mathijs C M Bunck; Anja Cornér; Bjorn Eliasson; Robert J Heine; Rimma M Shaginian; Ulf Smith; Marja-Riitta Taskinen; Hannele Yki-Järvinen; Michaela Diamant
Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes.
Diabetes care 2011;34(9):2041-7.
2011: Judith C Kuenen; Dirk J Kuik; David M Nathan; David Schoenfeld; Hui Zheng; Rikke Borg; Michaela Diamant; Robert J Heine
Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?
Diabetes care 2011;34(8):1843-7.
2011: Leonard P van der Zwan; Peter G Scheffer; Jacqueline M Dekker; Coen D A Stehouwer; Robert J Heine; Tom Teerlink
Systemic inflammation is linked to low arginine and high ADMA plasma levels resulting in an unfavourable NOS substrate-to-inhibitor ratio: the Hoorn Study.
Clinical science (London, England : 1979) 2011;121(2):71-8.
2011: A M C Simonis-Bik; Dorret I Boomsma; Jacqueline M Dekker; Michaela Diamant; E J C de Geus; L M 't Hart; Robert J Heine; Mark H H Kramer; J Antonie Maassen; Andrea Mari; A Tura; Gonneke Willemsen; E M W Eekhoff
The heritability of beta cell function parameters in a mixed meal test design.
Diabetologia 2011;54(5):1043-51.
2011: F Pouwer; Cees J Tack; P H L M Geelhoed-Duijvestijn; E Bazelmans; Aartjan T F Beekman; Robert J Heine; Frank J Snoek
Limited effect of screening for depression with written feedback in outpatients with diabetes mellitus: a randomised controlled trial.
Diabetologia 2011;54(4):741-8.
2011: Mathijs C M Bunck; B Eliasson; Anja Cornér; Robert J Heine; R M Shaginian; Marja-Riitta Taskinen; Hannele Yki-Järvinen; U Smith; Michaela Diamant
Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes.
Diabetes, obesity & metabolism 2011;13(4):374-7.
2010: Martin Heni; Caroline Ketterer; Leen M 't Hart; Felicia Ranta; Timon W van Haeften; E M W Eekhoff; Jacqueline M Dekker; Dorret I Boomsma; Giel Nijpels; Mark H Kramer; Michaela Diamant; Annemarie M Simonis-Bik; Robert J Heine; Eco J de Geus; Silke A Schäfer; Fausto Machicao; Susanne Ullrich; Claus Thamer; Norbert Stefan; Harald Staiger; Hans-Ulrich Häring; Andreas Fritsche
The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.
The Journal of clinical endocrinology and metabolism 2010;95(12):E479-84.
2010: Leonard P van der Zwan; Tom Teerlink; Jacqueline M Dekker; Ronald M A Henry; Coen D A Stehouwer; Cornelis Jakobs; Robert J Heine; Peter G Scheffer
Plasma myeloperoxidase is inversely associated with endothelium-dependent vasodilation in elderly subjects with abnormal glucose metabolism.
Metabolism: clinical and experimental 2010;59(12):1723-9.
2010: Mathijs C M Bunck; Anja Cornér; Bjorn Eliasson; Robert J Heine; Rimma M Shaginian; Yan Wu; Ping Yan; Ulf Smith; Hannele Yki-Järvinen; Michaela Diamant; Marja-Riitta Taskinen
One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress.
Atherosclerosis 2010;212(1):223-9.
2010: Mathijs C M Bunck; Michaela Diamant; Bjorn Eliasson; Anja Cornér; Rimma M Shaginian; Robert J Heine; Marja-Riitta Taskinen; Hannele Yki-Järvinen; Ulf Smith
Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition.
Diabetes care 2010;33(8):1734-7.
2010: Luuk J Rijzewijk; Jacqueline T Jonker; Rutger W van der Meer; Mark Lubberink; Hugo W A M de Jong; Johannes A Romijn; Jeroen J Bax; Albert de Roos; Robert J Heine; Jos W Twisk; Albert D Windhorst; Adriaan A Lammertsma; Johannes W A Smit; Michaela Diamant; Hildo J Lamb
Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes.
Journal of the American College of Cardiology 2010;56(3):225-33.
2010: K M P van Bastelaar; Francois Pouwer; P H L M Geelhoed-Duijvestijn; Cees J Tack; E Bazelmans; Aartjan T F Beekman; Robert J Heine; Frank J Snoek
Diabetes-specific emotional distress mediates the association between depressive symptoms and glycaemic control in Type 1 and Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2010;27(7):798-803.
2010: Maarten E Tushuizen; Petra J W Pouwels; Saskia Bontemps; Cees Rustemeijer; Niina Matikainen; Robert J Heine; Marja-Riitta Taskinen; Michaela Diamant
Postprandial lipid and apolipoprotein responses following three consecutive meals associate with liver fat content in type 2 diabetes and the metabolic syndrome.
Atherosclerosis 2010;211(1):308-14.
2010: Leonard P Van der Zwan; Peter G Scheffer; Jacqueline M Dekker; Coen D A Stehouwer; Robert J Heine; Tom Teerlink
Hyperglycemia and oxidative stress strengthen the association between myeloperoxidase and blood pressure.
Hypertension 2010;55(6):1366-72.
2010: Marjan Alssema; Karim El Harchaoui; Roger K Schindhelm; Michaela Diamant; Giel Nijpels; Piet J Kostense; Tom Teerlink; Robert J Heine; Geesje M Dallinga-Thie; Jan Albert Kuivenhoven; Jacqueline M Dekker; Peter G Scheffer
Fasting cholesteryl ester transfer protein concentration is independently associated with the postprandial decrease in high-density lipoprotein cholesterol concentration after fat-rich meals: the Hoorn prandial study.
Metabolism: clinical and experimental 2010;59(6):854-60.
2010: Esther van den Berg; Geert Jan Biessels; Coen D A Stehouwer; L Jaap Kappelle; Robert J Heine; Giel Nijpels; Jacqueline M Dekker
Ten-year time course of risk factors for increased carotid intima-media thickness: the Hoorn Study.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2010;17(2):168-74.
2010: Francois Pouwer; P H L M Geelhoed-Duijvestijn; Cees J Tack; E Bazelmans; A-J Beekman; Robert J Heine; Frank J Snoek
Prevalence of comorbid depression is high in out-patients with Type 1 or Type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands.
Diabetic medicine : a journal of the British Diabetic Association 2010;27(2):217-24.
2010: Annemarie M Simonis-Bik; Giel Nijpels; Timon W van Haeften; Jeanine J Houwing-Duistermaat; Dorret I Boomsma; Erwin Reiling; Els C van Hove; Michaela Diamant; Mark H H Kramer; Robert J Heine; J Antonie Maassen; P Eline Slagboom; Gonneke Willemsen; Jacqueline M Dekker; E M W Eekhoff; Eco J de Geus; Leen M 't Hart
Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.
Diabetes 2010;59(1):293-301.
2010: Leen M 't Hart; Annemarie M Simonis-Bik; Giel Nijpels; Timon W van Haeften; Silke A Schäfer; Jeanine J Houwing-Duistermaat; Dorret I Boomsma; Marlous J Groenewoud; Erwin Reiling; Els C van Hove; Michaela Diamant; Mark H H Kramer; Robert J Heine; J Antonie Maassen; Kerstin Kirchhoff; Fausto Machicao; Hans-Ulrich Häring; P Eline Slagboom; Gonneke Willemsen; E M W Eekhoff; Eco J de Geus; Jacqueline M Dekker; Andreas Fritsche
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
Diabetes 2010;59(1):287-92.
2009: A M C Simonis-Bik; E M W Eekhoff; M H M de Moor; Mark H H Kramer; Dorret I Boomsma; Robert J Heine; Jacqueline M Dekker; J Antonie Maassen; L M 't Hart; Michaela Diamant; E J C de Geus
Genetic influences on the insulin response of the beta cell to different secretagogues.
Diabetologia 2009;52(12):2570-7.
2009: Luuk J Rijzewijk; Rutger W van der Meer; Hildo J Lamb; Hugo W A M de Jong; Mark Lubberink; Johannes A Romijn; Jeroen J Bax; Albert de Roos; Jos W Twisk; Robert J Heine; Adriaan A Lammertsma; Johannes W A Smit; Michaela Diamant
Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging.
Journal of the American College of Cardiology 2009;54(16):1524-32.
2009: Vokko P van Halm; M J L Peters; Alexandre E Voskuyl; Maarten Boers; Willem F Lems; Marjolein Visser; C D A Stehouwer; Annemieke M W Spijkerman; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Yvo M Smulders; B A C Dijkmans; Michael T Nurmohamed
Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE Investigation.
Annals of the rheumatic diseases 2009;68(9):1395-400.
2009: Erwin Reiling; Jana V van Vliet-Ostaptchouk; Esther van 't Riet; Timon W van Haeften; Pascal A Arp; Torben Hansen; Dennis Kremer; Marlous J Groenewoud; Els C van Hove; Johannes A Romijn; Jan W A Smit; Giel Nijpels; Robert J Heine; André G Uitterlinden; Oluf Pedersen; P Eline Slagboom; J Antonie Maassen; Marten H Hofker; Leen M 't Hart; Jacqueline M Dekker
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.
European journal of human genetics : EJHG 2009;17(8):1056-62.
2009: Mathijs C M Bunck; Michaela Diamant; Anja Cornér; Bjorn Eliasson; Jaret L Malloy; Rimma M Shaginian; Wei Deng; David M Kendall; Marja-Riitta Taskinen; Ulf Smith; Hannele Yki-Järvinen; Robert J Heine
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.
Diabetes care 2009;32(5):762-8.
2009: Rutger W van der Meer; Luuk J Rijzewijk; Hugo W A M de Jong; Hildo J Lamb; Mark Lubberink; Johannes A Romijn; Jeroen J Bax; Albert de Roos; Otto Kamp; Walter J Paulus; Robert J Heine; Adriaan A Lammertsma; Johannes W A Smit; Michaela Diamant
Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus.
Circulation 2009;119(15):2069-77.
2009: Marieke B Snijder; A Flyvbjerg; C D A Stehouwer; J Frystyk; Ronald M A Henry; jacob seidell; Robert J Heine; Jacqueline M Dekker
Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(3):387-95.
2009: Marjan Alssema; Roger K Schindhelm; Josina M Rijkelijkhuizen; Piet J Kostense; Tom Teerlink; Giel Nijpels; Robert J Heine; Jacqueline M Dekker
Meal composition affects insulin secretion in women with type 2 diabetes: a comparison with healthy controls. The Hoorn prandial study.
European journal of clinical nutrition 2009;63(3):398-404.
2009: Josina M Rijkelijkhuizen; Cynthia J Girman; Andrea Mari; Marjan Alssema; Thomas Rhodes; Giel Nijpels; Piet J Kostense; Peter P Stein; Elisabeth M Eekhoff; Robert J Heine; Jacqueline M Dekker
Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort.
Diabetes research and clinical practice 2009;83(2):280-8.
2009: Leonard P van der Zwan; Tom Teerlink; Jacqueline M Dekker; Ronald M A Henry; Coen D A Stehouwer; Cornelis Jakobs; Robert J Heine; Peter G Scheffer
Circulating oxidized LDL: determinants and association with brachial flow-mediated dilation.
Journal of lipid research 2009;50(2):342-9.
2008: Wiebe Boorsma; Marieke B Snijder; Giel Nijpels; Caterina Guidone; Angela M R Favuzzi; Geltrude Mingrone; Piet J Kostense; Robert J Heine; Jacqueline M Dekker
Body composition, insulin sensitivity, and cardiovascular disease profile in healthy Europeans.
Obesity (Silver Spring, Md.) 2008;16(12):2696-701.
2008: Marcel C Adriaanse; Frans Pouwer; Jacqueline M Dekker; Giel Nijpels; Coen D Stehouwer; Robert J Heine; Frank J Snoek
Diabetes-related symptom distress in association with glucose metabolism and comorbidity: the Hoorn Study.
Diabetes care 2008;31(12):2268-70.
2008: Frank J Snoek; Nicole C W Van Der Ven; Jos W R Twisk; M H E Hogenelst; A M E Tromp-Wever; Henk M van der Ploeg; Robert J Heine
Cognitive behavioural therapy (CBT) compared with blood glucose awareness training (BGAT) in poorly controlled Type 1 diabetic patients: long-term effects on HbA moderated by depression. A randomized controlled trial.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(11):1337-42.
2008: Giel Nijpels; W Boorsma; Jacqueline M Dekker; Piet J Kostense; Lex M Bouter; Robert J Heine
A study of the effects of acarbose on glucose metabolism in patients predisposed to developing diabetes: the Dutch acarbose intervention study in persons with impaired glucose tolerance (DAISI).
Diabetes/metabolism research and reviews 2008;24(8):611-6.
2008: Marcel C Adriaanse; Jos W R Twisk; Jacqueline M Dekker; Annemieke M W Spijkerman; Giel Nijpels; Robert J Heine; Frank J Snoek
Perceptions of risk in adults with a low or high risk profile of developing type 2 diabetes; a cross-sectional population-based study.
Patient education and counseling 2008;73(2):307-12.
2008: Marjan Alssema; Roger K Schindhelm; Jacqueline M Dekker; Michaela Diamant; Giel Nijpels; Tom Teerlink; Peter G Scheffer; Piet J Kostense; Robert J Heine
Determinants of postprandial triglyceride and glucose responses after two consecutive fat-rich or carbohydrate-rich meals in normoglycemic women and in women with type 2 diabetes mellitus: the Hoorn Prandial Study.
Metabolism: clinical and experimental 2008;57(9):1262-9.
2008: M J Groenewoud; Jacqueline M Dekker; A Fritsche; Erwin Reiling; Giel Nijpels; Robert J Heine; J Antonie Maassen; Fausto Machicao; S A Schäfer; Hans-Ulrich Häring; L M 't Hart; Timon W van Haeften
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.
Diabetologia 2008;51(9):1659-63.
2008: Peter G Scheffer; Tom Teerlink; Jacqueline M Dekker; Griët Bos; Giel Nijpels; Michaela Diamant; Piet J Kostense; Coen D A Stehouwer; Robert J Heine
Increased plasma apolipoprotein C-III concentration independently predicts cardiovascular mortality: the Hoorn Study.
Clinical chemistry 2008;54(8):1325-30.
2008: Marcel C Adriaanse; Jacqueline M Dekker; Robert J Heine; Frank J Snoek; A J Beekman; Coen D A Stehouwer; Lex M Bouter; Giel Nijpels; Francois Pouwer
Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(7):843-9.
2008: Nanouk G M Wiemer; Elisabeth M W Eekhoff; Suat Simsek; Robert J Heine; Peter J Ringens; Bettine C P Polak; Michiel Dubbelman
Refractive properties of the healthy human eye during acute hyperglycemia.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2008;246(7):993-8.
2008: Alette M Wessels; Philip scheltens; Frederik Barkhof; Robert J Heine
Hyperglycaemia as a determinant of cognitive decline in patients with type 1 diabetes.
European journal of pharmacology 2008;585(1):88-96.
2008: A W van Deutekom; Hans W M Niessen; Casper G Schalkwijk; Robert J Heine; S Simsek
Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(5):655-60.
2008: J Antonie Maassen; Johannes A Romijn; Robert J Heine
Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?
Diabetologia 2008;51(5):907-8.
2008: Nanouk G M Wiemer; Elisabeth M W Eekhoff; Suat Simsek; Robert J Heine; Peter J Ringens; Bettine C P Polak; Michiel Dubbelman
The effect of acute hyperglycemia on retinal thickness and ocular refraction in healthy subjects.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2008;246(5):703-8.
2008: Marc M H Hermans; Ronald M A Henry; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Coen D A Stehouwer
Albuminuria, but not estimated glomerular filtration rate, is associated with maladaptive arterial remodeling: the Hoorn Study.
Journal of hypertension 2008;26(4):791-7.
2008: Jacqueline M Dekker; Tohru Funahashi; Giel Nijpels; Stefan Pilz; Coen D A Stehouwer; Marieke B Snijder; Lex M Bouter; Yuji Matsuzawa; Iichiro Shimomura; Robert J Heine
Prognostic value of adiponectin for cardiovascular disease and mortality.
The Journal of clinical endocrinology and metabolism 2008;93(4):1489-96.
2008: Ronald M A Henry; W J Paulus; Otto Kamp; Piet J Kostense; Annemieke M W Spijkerman; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; C D A Stehouwer
Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study.
The Netherlands journal of medicine 2008;66(3):110-7.
2008: Marieke B Snijder; Rob van Dam; Coen D A Stehouwer; Gerrit J Hiddink; Robert J Heine; Jacqueline M Dekker
A prospective study of dairy consumption in relation to changes in metabolic risk factors: the Hoorn Study.
Obesity (Silver Spring, Md.) 2008;16(3):706-9.
2008: Roger K Schindhelm; Marjan Alssema; Michaela Diamant; Tom Teerlink; Jacqueline M Dekker; astrid kok; Piet J Kostense; Giel Nijpels; Robert J Heine; Peter G Scheffer
Comparison of two consecutive fat-rich and carbohydrate-rich meals on postprandial myeloperoxidase response in women with and without type 2 diabetes mellitus.
Metabolism: clinical and experimental 2008;57(2):262-7.
2008: A W van Deutekom; Robert J Heine; S Simsek
The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(2):117-25.
2008: Marjan Alssema; Roger K Schindhelm; Jacqueline M Dekker; Michaela Diamant; Piet J Kostense; Tom Teerlink; Peter G Scheffer; Giel Nijpels; Robert J Heine
Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn prandial study.
Atherosclerosis 2008;196(2):712-9.
2007: Maarten E Tushuizen; Mathijs C Bunck; Petra J Pouwels; Saskia Bontemps; Jan Hein T van Waesberghe; Roger K Schindhelm; Andrea Mari; Robert J Heine; Michaela Diamant
Pancreatic fat content and beta-cell function in men with and without type 2 diabetes.
Diabetes care 2007;30(11):2916-21.
2007: J Antonie Maassen; Johannes A Romijn; Robert J Heine
Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus.
Diabetologia 2007;50(10):2036-41.
2007: Roger K Schindhelm; Robert J Heine; Michaela Diamant
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients.
Diabetes care 2007;30(9):e94; author reply e95.
2007: Alette M Wessels; Serge A R B Rombouts; Peter L Remijnse; Y Boom; Philip scheltens; Frederik Barkhof; Robert J Heine; Frank J Snoek
Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume.
Diabetologia 2007;50(8):1763-9.
2007: Robert J Heine; Robert G Brodows
Diabetic gastroparesis.
The New England journal of medicine 2007;357(4):418; author reply 419-20.
2007: Roger K Schindhelm; Marjan Alssema; Peter G Scheffer; Michaela Diamant; Jacqueline M Dekker; Rob Barto; Giel Nijpels; Piet J Kostense; Robert J Heine; Casper G Schalkwijk; Tom Teerlink
Fasting and postprandial glycoxidative and lipoxidative stress are increased in women with type 2 diabetes.
Diabetes care 2007;30(7):1789-94.
2007: Alette M Wessels; Francois Pouwer; P H L M Geelhoed-Duijvestijn; Mireille H J Snel; Piet J Kostense; Philip scheltens; Robert J Heine; Frank J Snoek
No evidence for increased self-reported cognitive failure in Type 1 and Type 2 diabetes: a cross-sectional study.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(7):735-40.
2007: Roger K Schindhelm; Michaela Diamant; Robert J Heine
Nonalcoholic fatty liver disease and cardiovascular disease risk.
Current diabetes reports 2007;7(3):181-7.
2007: I M E Wentholt; Alberto Maran; Nathalie Masurel; Robert J Heine; J B L Hoekstra; J Hans DeVries
Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(5):527-32.
2007: Marieke B Snijder; Amber Awa van der Heijden; Rob van Dam; Coen D A Stehouwer; Gerrit J Hiddink; Giel Nijpels; Robert J Heine; Lex M Bouter; Jacqueline M Dekker
Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study.
The American journal of clinical nutrition 2007;85(4):989-95.
2007: Roger K Schindhelm; Jacqueline M Dekker; Giel Nijpels; C D A Stehouwer; Lex M Bouter; Robert J Heine; Michaela Diamant
Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(4):430-5.
2007: Roger K Schindhelm; Jacqueline M Dekker; Giel Nijpels; Lex M Bouter; Coen D A Stehouwer; Robert J Heine; Michaela Diamant
Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study.
Atherosclerosis 2007;191(2):391-6.
2007: Rob van Dam; Marieke B Snijder; Jacqueline M Dekker; Coen D A Stehouwer; Lex M Bouter; Robert J Heine; Paul Lips
Potentially modifiable determinants of vitamin D status in an older population in the Netherlands: the Hoorn Study.
The American journal of clinical nutrition 2007;85(3):755-61.
2007: Maarten E Tushuizen; Rienk Nieuwland; Cees Rustemeijer; Bert E Hensgens; Augueste Sturk; Robert J Heine; Michaela Diamant
Elevated endothelial microparticles following consecutive meals are associated with vascular endothelial dysfunction in type 2 diabetes.
Diabetes care 2007;30(3):728-30.
2007: Jolita Ciapaite; Stephan J L Bakker; Gerco Van Eikenhorst; Marijke J Wagner; Tom Teerlink; Casper G Schalkwijk; Mariann Fodor; D Margriet Ouwens; Michaela Diamant; Robert J Heine; Hans V Westerhoff; Klaas Krab
Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.
Biochimica et biophysica acta 2007;1772(3):307-16.
2007: Josina M Rijkelijkhuizen; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer; Jacqueline M Dekker
High risk of cardiovascular mortality in individuals with impaired fasting glucose is explained by conversion to diabetes: the Hoorn study.
Diabetes care 2007;30(2):332-6.
2007: Marjan Alssema; Jacqueline M Dekker; J A Kuivenhoven; Giel Nijpels; Tom Teerlink; Peter G Scheffer; Michaela Diamant; C D A Stehouwer; Lex M Bouter; Robert J Heine
Elevated cholesteryl ester transfer protein concentration is associated with an increased risk for cardiovascular disease in women, but not in men, with Type 2 diabetes: the Hoorn Study.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(2):117-23.
2007: Jolita Ciapaite; Jan van Bezu; Gerco Van Eikenhorst; Stephan J L Bakker; Tom Teerlink; Michaela Diamant; Robert J Heine; Klaas Krab; Hans V Westerhoff; Casper G Schalkwijk
Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells.
Biochimica et biophysica acta 2007;1771(2):147-54.
2007: Griët Bos; M C Poortvliet; Peter G Scheffer; Jacqueline M Dekker; Marga C Ocke; Giel Nijpels; C D A Stehouwer; Lex M Bouter; Tom Teerlink; Robert J Heine
Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study.
European journal of clinical nutrition 2007;61(2):205-11.
2007: Marieke B Snijder; Jacqueline M Dekker; Lex M Bouter; Robert J Heine; C D A Stehouwer; jacob seidell
Comment on: Schmidt MI, Duncan BB, Vigo A et al (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086-2096.
Diabetologia 2007;50(1):234-6; author reply 237-8; discussion 239-40.
2006: Robert J Heine; Michaela Diamant; J-C Mbanya; D M Nathan
Management of hyperglycaemia in type 2 diabetes: the end of recurrent failure?
BMJ (Clinical research ed.) 2006;333(7580):1200-4.
2006: Marcel C Adriaanse; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Frank J Snoek; Francois Pouwer
Associations between depressive symptoms and insulin resistance: the Hoorn Study.
Diabetologia 2006;49(12):2874-7.
2006: Jolita Ciapaite; Stephan J L Bakker; Michaela Diamant; Gerco Van Eikenhorst; Robert J Heine; Hans V Westerhoff; Klaas Krab
Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects. Implications for a mechanism linking obesity and type 2 diabetes.
The FEBS journal 2006;273(23):5288-302.
2006: Janine Mukuddem-Petersen; Marieke B Snijder; Rob van Dam; Jacqueline M Dekker; Lex M Bouter; Coen D A Stehouwer; Robert J Heine; Giel Nijpels; jacob seidell
Sagittal abdominal diameter: no advantage compared with other anthropometric measures as a correlate of components of the metabolic syndrome in elderly from the Hoorn Study.
The American journal of clinical nutrition 2006;84(5):995-1002.
2006: Marieke B Snijder; Robert J Heine; jacob seidell; Lex M Bouter; Coen D A Stehouwer; Giel Nijpels; Tohru Funahashi; Yuji Matsuzawa; Iichiro Shimomura; Jacqueline M Dekker
Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the hoorn study.
Diabetes care 2006;29(11):2498-503.
2006: Els C van Hove; Torben Hansen; Jacqueline M Dekker; Erwin Reiling; Giel Nijpels; Torben Jørgensen; Knut Borch-Johnsen; Yasmin H Hamid; Robert J Heine; Oluf Pedersen; J Antonie Maassen; Leen M 't Hart
The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study.
Diabetes 2006;55(11):3193-6.
2006: Roger K Schindhelm; Michaela Diamant; Jacqueline M Dekker; Maarten E Tushuizen; Tom Teerlink; Robert J Heine
Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease.
Diabetes/metabolism research and reviews 2006;22(6):437-43.
2006: Maarten E Tushuizen; Mathijs C Bunck; Petra J Pouwels; Jan Hein T van Waesberghe; Michaela Diamant; Robert J Heine
Incretin mimetics as a novel therapeutic option for hepatic steatosis.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(8):1015-7.
2006: Alette M Wessels; Suat Simsek; Peter L Remijnse; Dick J Veltman; Geert Jan Biessels; Frederik Barkhof; Philip scheltens; Frank J Snoek; Robert J Heine; Serge A R B Rombouts
Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy.
Diabetologia 2006;49(10):2474-80.
2006: Laura M C Welschen; Evelien Bloemendal; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Wim A B Stalman; Lex M Bouter
[From the Cochrane Library and Diabetes Care: self-monitoring of blood glucose probably an effective way to improve glycaemic control in patients with type 2 diabetes not taking insulin].
Nederlands tijdschrift voor geneeskunde 2006;150(33):1826-9.
2006: G Sophie Mijnhout; Philip scheltens; M Diamant; Geert Jan Biessels; Alette M Wessels; Suat Simsek; Frank J Snoek; Robert J Heine
Diabetic encephalopathy: A concept in need of a definition.
Diabetologia 2006;49(6):1447-8.
2006: Maarten E Tushuizen; Rienk Nieuwland; Peter G Scheffer; Augueste Sturk; Robert J Heine; Michaela Diamant
Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men.
Journal of thrombosis and haemostasis : JTH 2006;4(5):1003-10.
2006: Manon V Van Hecke; Jacqueline M Dekker; Giel Nijpels; Ronald P Stolk; Ronald M A Henry; Robert J Heine; Lex M Bouter; Coen D A Stehouwer; Bettine C P Polak
Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intima-media thickness? The Hoorn Study.
Clinical science (London, England : 1979) 2006;110(5):597-604.
2006: Max Nieuwdorp; Hans L Mooij; Jojanneke Kroon; Bektas Atasever; Jos A E Spaan; Can Ince; Frits Holleman; Michaela Diamant; Robert J Heine; J B L Hoekstra; John J P Kastelein; Erik S G Stroes; Hans Vink
Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
Diabetes 2006;55(4):1127-32.
2006: Lando L J Koppes; Jacqueline M Dekker; Henk F.J. Hendriks; Lex M Bouter; Robert J Heine
Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients.
Diabetologia 2006;49(4):648-52.
2006: Robert J Heine
The role of postprandial hyperglycemia and hyperlipidemia in CVD risk.
Current diabetes reports 2006;6(1):1-2.
2006: Alette M Wessels; Serge A R B Rombouts; Suat Simsek; Joost P A Kuijer; Piet J Kostense; Frederik Barkhof; Philip scheltens; Frank J Snoek; Robert J Heine
Microvascular disease in type 1 diabetes alters brain activation: a functional magnetic resonance imaging study.
Diabetes 2006;55(2):334-40.
2005: A M E Spoelstra-De Man; Yvo M Smulders; Jacqueline M Dekker; Robert J Heine; Lex M Bouter; Giel Nijpels; C D A Stehouwer
Homocysteine levels are not associated with cardiovascular autonomic function in elderly Caucasian subjects without or with type 2 diabetes mellitus: the Hoorn Study.
Journal of internal medicine 2005;258(6):536-43.
2005: Roger K Schindhelm; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Michaela Diamant
No independent association of alanine aminotransferase with risk of future type 2 diabetes in the Hoorn study.
Diabetes care 2005;28(11):2812.
2005: Nicole C W Van Der Ven; M H E Hogenelst; A M E Tromp-Wever; Jos W R Twisk; Henk M van der Ploeg; Robert J Heine; Frank J Snoek
Short-term effects of cognitive behavioural group training (CBGT) in adult Type 1 diabetes patients in prolonged poor glycaemic control. A randomized controlled trial.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(11):1619-23.
2005: Francois Pouwer; Giel Nijpels; A T Beekman; Jacqueline M Dekker; Rob van Dam; Robert J Heine; Frank J Snoek
Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids? A review of the evidence.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(11):1465-75.
2005: Robert J Heine
Unlocking the opportunity of tight glycaemic control. Promise ahead: the role of inhaled insulin in clinical practice.
Diabetes, obesity & metabolism 2005;7 Suppl 1():S19-23.
2005: Robert J Heine; Luc F Van Gaal; Don Johns; Michael J Mihm; Mario H Widel; Robert G Brodows
Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial.
Annals of internal medicine 2005;143(8):559-69.
2005: Griët Bos; Marieke B Snijder; Giel Nijpels; Jacqueline M Dekker; Coen D A Stehouwer; Lex M Bouter; Robert J Heine; Hans Jansen
Opposite contributions of trunk and leg fat mass with plasma lipase activities: the Hoorn study.
Obesity research 2005;13(10):1817-23.
2005: Jacqueline M Dekker; Cynthia Girman; Thomas Rhodes; Giel Nijpels; Coen D A Stehouwer; Lex M Bouter; Robert J Heine
Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study.
Circulation 2005;112(5):666-73.
2005: Marcel C Adriaanse; Jacqueline M Dekker; Annemieke M W Spijkerman; Jos W R Twisk; Giel Nijpels; Henk M van der Ploeg; Robert J Heine; Frank J Snoek
Diabetes-related symptoms and negative mood in participants of a targeted population-screening program for type 2 diabetes: The Hoorn Screening Study.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2005;14(6):1501-9.
2005: Ronald M A Henry; Otto Kamp; Piet J Kostense; Annemieke M W Spijkerman; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Mild renal insufficiency is associated with increased left ventricular mass in men, but not in women: an arterial stiffness-related phenomenon--the Hoorn Study.
Kidney international 2005;68(2):673-9.
2005: Manon V Van Hecke; Jacqueline M Dekker; Giel Nijpels; Annette C Moll; Robert J Heine; Lex M Bouter; Bettine C P Polak; C D A Stehouwer
Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study.
Diabetologia 2005;48(7):1300-6.
2005: Roger K Schindhelm; Michaela Diamant; Stephan J L Bakker; R A J M van Dijk; Peter G Scheffer; Tom Teerlink; Piet J Kostense; Robert J Heine
Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus.
European journal of clinical investigation 2005;35(6):369-74.
2005: Laura M C Welschen; Evelien Bloemendal; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Wim A B Stalman; Lex M Bouter
Self-monitoring of blood glucose in patients with type 2 diabetes who are not using insulin: a systematic review.
Diabetes care 2005;28(6):1510-7.
2005: Leen M 't Hart; Torben Hansen; Ingrid Rietveld; Jacqueline M Dekker; Giel Nijpels; George M C Janssen; Pascal A Arp; André G Uitterlinden; Torben Jørgensen; Knut Borch-Johnsen; Huibert A P Pols; Oluf Pedersen; C.M. Duijn; Robert J Heine; J Antonie Maassen
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.
Diabetes 2005;54(6):1892-5.
2005: D Margriet Ouwens; Christa Boer; Mariann Fodor; P de Galan; Robert J Heine; J Antonie Maassen; Michaela Diamant
Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats.
Diabetologia 2005;48(6):1229-37.
2005: Peter G Scheffer; Tom Teerlink; Robert J Heine
Clinical significance of the physicochemical properties of LDL in type 2 diabetes.
Diabetologia 2005;48(5):808-16.
2005: Griët Bos; Jacqueline M Dekker; Edith J M Feskens; Marga C Ocke; Giel Nijpels; Coen D A Stehouwer; Lex M Bouter; Robert J Heine; Hans Jansen
Interactions of dietary fat intake and the hepatic lipase -480C-->T polymorphism in determining hepatic lipase activity: the Hoorn Study.
The American journal of clinical nutrition 2005;81(4):911-5.
2005: Jolita Ciapaite; Gerco Van Eikenhorst; Stephan J L Bakker; Michaela Diamant; Robert J Heine; Marijke J Wagner; Hans V Westerhoff; Klaas Krab
Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria.
Diabetes 2005;54(4):944-51.
2005: Marjan Alssema; Jacqueline M Dekker; Giel Nijpels; Coen D A Stehouwer; Lex M Bouter; Robert J Heine
Proinsulin concentration is an independent predictor of all-cause and cardiovascular mortality: an 11-year follow-up of the Hoorn Study.
Diabetes care 2005;28(4):860-5.
2005: Annemieke M W Spijkerman; Yvo M Smulders; Piet J Kostense; Ronald M A Henry; A Becker; Tom Teerlink; Cornelis Jakobs; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; C D A Stehouwer
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):778-84.
2005: Lando L J Koppes; Jacqueline M Dekker; Henk F.J. Hendriks; Lex M Bouter; Robert J Heine
Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies.
Diabetes care 2005;28(3):719-25.
2005: Nicole C W Van Der Ven; Caroline H C Lubach; Marloes H E Hogenelst; Ada van Iperen; Anita M E Tromp-Wever; Annelies Vriend; Henk M van der Ploeg; Robert J Heine; Frank J Snoek
Cognitive behavioural group training (CBGT) for patients with type 1 diabetes in persistent poor glycaemic control: who do we reach?
Patient education and counseling 2005;56(3):313-22.
2005: Laura M C Welschen; Evelien Bloemendal; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Wim A B Stalman; Lex M Bouter
Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin.
Cochrane database of systematic reviews (Online) 2005;(2):CD005060.
2005: Maarten E Tushuizen; Michaela Diamant; Robert J Heine
Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes.
Postgraduate medical journal 2005;81(951):1-6.
2004: Rob van Dam; Jacqueline M Dekker; Giel Nijpels; C D A Stehouwer; Lex M Bouter; Robert J Heine
Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study.
Diabetologia 2004;47(12):2152-9.
2004: J Hans DeVries; Frank J Snoek; Robert J Heine
Persistent poor glycaemic control in adult Type 1 diabetes. A closer look at the problem.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(12):1263-8.
2004: J Hans DeVries; I M E Wentholt; Nathalie Masurel; Itske Mantel; Alessandro Poscia; Alberto Maran; Robert J Heine
Nocturnal hypoglycaemia in type 1 diabetes--consequences and assessment.
Diabetes/metabolism research and reviews 2004;20 Suppl 2():S43-6.
2004: Annemieke M W Spijkerman; Ronald M A Henry; Jacqueline M Dekker; Giel Nijpels; Piet J Kostense; Jan A Kors; Dirk Ruwaard; C D A Stehouwer; Lex M Bouter; Robert J Heine
Prevalence of macrovascular disease amongst type 2 diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn Screening Study.
Journal of internal medicine 2004;256(5):429-36.
2004: Coen D A Stehouwer; Ronald M A Henry; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter
Microalbuminuria is associated with impaired brachial artery, flow-mediated vasodilation in elderly individuals without and with diabetes: further evidence for a link between microalbuminuria and endothelial dysfunction--the Hoorn Study.
Kidney international. Supplement 2004;(92):S42-4.
2004: Marcel C Adriaanse; Jacqueline M Dekker; Annemieke M W Spijkerman; Jos W R Twisk; Giel Nijpels; Henk M van der Ploeg; Robert J Heine; Frank J Snoek
Health-related quality of life in the first year following diagnosis of Type 2 diabetes: newly diagnosed patients in general practice compared with screening-detected patients. The Hoorn Screening Study.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(10):1075-81.
2004: Marcel C Adriaanse; Frank J Snoek; Jacqueline M Dekker; Annemieke M W Spijkerman; Giel Nijpels; Jos W R Twisk; Henk M van der Ploeg; Robert J Heine
No substantial psychological impact of the diagnosis of Type 2 diabetes following targeted population screening: The Hoorn Screening Study.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(9):992-8.
2004: Peter G Scheffer; Ronald M A Henry; E J M Wever; G J van Rooij; Griët Bos; Robert J Heine; Jacqueline M Dekker; Michaela Diamant; C D A Stehouwer; Giel Nijpels; M A Blankenstein; Tom Teerlink
LDL oxidative modifications in well- or moderately controlled type 2 diabetes.
Diabetes/metabolism research and reviews 2004;20(4):298-304.
2004: Qing Qiao; Jacqueline M Dekker; Femmie de Vegt; Giel Nijpels; Aulikki Nissinen; Coen D A Stehouwer; Lex M Bouter; Robert J Heine; Jaakko Tuomilehto
Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c.
Journal of clinical epidemiology 2004;57(6):590-6.
2004: Ischa Stranders; Michaela Diamant; Rogier E van Gelder; Hugo J Spruijt; Jos W R Twisk; Robert J Heine; Frans C Visser
Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus.
Archives of internal medicine 2004;164(9):982-8.
2004: Ronald M A Henry; Isabel Ferreira; Piet J Kostense; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Otto Kamp; Lex M Bouter; Coen D A Stehouwer
Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not; The Hoorn Study.
Atherosclerosis 2004;174(1):49-56.
2004: Tom Teerlink; Peter G Scheffer; Stephan J L Bakker; Robert J Heine
Combined data from LDL composition and size measurement are compatible with a discoid particle shape.
Journal of lipid research 2004;45(5):954-66.
2004: Robert J Heine; B Balkau; A Ceriello; Stefano Del Prato; E S Horton; M-R Taskinen
What does postprandial hyperglycaemia mean?
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):208-13.
2004: Griët Bos; Peter G Scheffer; Delfina Vieira; Jacqueline M Dekker; Giel Nijpels; Michaela Diamant; Tom Teerlink; Coen D A Stehouwer; Lex M Bouter; Robert J Heine; Hans Jansen
The relationship of lipoprotein lipase activity and LDL size is dependent on glucose metabolism in an elderly population: the Hoorn Study.
Diabetes care 2004;27(3):796-8.
2004: Ronald M A Henry; Piet J Kostense; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Otto Kamp; Lex M Bouter; Coen D A Stehouwer
Carotid arterial remodeling: a maladaptive phenomenon in type 2 diabetes but not in impaired glucose metabolism: the Hoorn study.
Stroke; a journal of cerebral circulation 2004;35(3):671-6.
2004: Leen M 't Hart; Andreas Fritsche; Ingrid Rietveld; Jacqueline M Dekker; Giel Nijpels; Fausto Machicao; Michael Stumvoll; C.M. Duijn; Hans-Ulrich Häring; Robert J Heine; J Antonie Maassen; Timon W van Haeften
Genetic factors and insulin secretion: gene variants in the IGF genes.
Diabetes 2004;53 Suppl 1():S26-30.
2004: Ronald M A Henry; Otto Kamp; Piet J Kostense; Annemieke M W Spijkerman; Jacqueline M Dekker; Rosemarie van Eijck; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Left ventricular mass increases with deteriorating glucose tolerance, especially in women: independence of increased arterial stiffness or decreased flow-mediated dilation: the Hoorn study.
Diabetes care 2004;27(2):522-9.
2004: Marieke B Snijder; Jacqueline M Dekker; Marjolein Visser; Lex M Bouter; Coen D A Stehouwer; John S Yudkin; Robert J Heine; Giel Nijpels; jacob seidell
Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study.
Diabetes care 2004;27(2):372-7.
2004: Miranda T Schram; Ronald M A Henry; R A J M van Dijk; Piet J Kostense; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Nico Westerhof; Coen D A Stehouwer
Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study.
Hypertension 2004;43(2):176-81.
2003: Manon V Van Hecke; Jacqueline M Dekker; Giel Nijpels; Annette C Moll; Hendrik A van Leiden; Robert J Heine; Lex M Bouter; Coen D A Stehouwer; Bettine C P Polak
Retinopathy is associated with cardiovascular and all-cause mortality in both diabetic and nondiabetic subjects: the hoorn study.
Diabetes care 2003;26(10):2958.
2003: Carry M Renders; Gerlof D Valk; J J J de Sonnaville; Jos W R Twisk; Didi M W Kriegsman; Robert J Heine; Jacques Th M van Eijk; Gerrit van der Wal
Quality of care for patients with Type 2 diabetes mellitus--a long-term comparison of two quality improvement programmes in the Netherlands.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(10):846-52.
2003: J Hans DeVries; Frank J Snoek; Piet J Kostense; Robert J Heine
Improved glycaemic control in type 1 diabetes patients following participation per se in a clinical trial--mechanisms and implications.
Diabetes/metabolism research and reviews 2003;19(5):357-62.
2003: Annemieke M W Spijkerman; Jacqueline M Dekker; Giel Nijpels; Marcel C Adriaanse; Piet J Kostense; Dirk Ruwaard; Coen D A Stehouwer; Lex M Bouter; Robert J Heine
Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the hoorn screening study.
Diabetes care 2003;26(9):2604-8.
2003: A Becker; Ronald M A Henry; Piet J Kostense; Cornelis Jakobs; Tom Teerlink; Sonja Zweegman; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Yvo M Smulders; C D A Stehouwer
Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals. The Hoorn Study.
Atherosclerosis 2003;169(2):323-30.
2003: Annemarie Becker; Griët Bos; Femmie de Vegt; Piet J Kostense; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Cardiovascular events in type 2 diabetes: comparison with nondiabetic individuals without and with prior cardiovascular disease. 10-year follow-up of the Hoorn Study.
European heart journal 2003;24(15):1406-13.
2003: Jacqueline M Dekker; M van der Kraan; Giel Nijpels; Femmie de Vegt; P J Kostense; C D A Stehouwer; Lex M Bouter; Robert J Heine
[Estimate of the number of new patients with type 2 diabetes mellitus in the Netherlands: at least 65,000 per year in the age group of 50 years and above].
Nederlands tijdschrift voor geneeskunde 2003;147(29):1419-23.
2003: Peter G Scheffer; Griët Bos; H G F M Volwater; Jacqueline M Dekker; Robert J Heine; Tom Teerlink
Associations of LDL size with in vitro oxidizability and plasma levels of in vivo oxidized LDL in Type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(7):563-7.
2003: Griët Bos; Jacqueline M Dekker; Giel Nijpels; Femmie de Vegt; Michaela Diamant; C D A Stehouwer; Lex M Bouter; Robert J Heine
A combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn Study.
Diabetologia 2003;46(7):910-6.
2003: Francois Pouwer; Aartjan T F Beekman; Giel Nijpels; Jacqueline M Dekker; Frank J Snoek; Piet J Kostense; Robert J Heine; Dorly J H Deeg
Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study.
Diabetologia 2003;46(7):892-8.
2003: Marieke B Snijder; Jacqueline M Dekker; Marjolein Visser; Lex M Bouter; Coen D A Stehouwer; Piet J Kostense; John S Yudkin; Robert J Heine; Giel Nijpels; jacob seidell
Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study.
The American journal of clinical nutrition 2003;77(5):1192-7.
2003: Ronald M A Henry; Piet J Kostense; Annemieke M W Spijkerman; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Otto Kamp; Nico Westerhof; Lex M Bouter; Coen D A Stehouwer
Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study.
Circulation 2003;107(16):2089-95.
2003: A Becker; F E E van der Does; Victor W M van Hinsbergh; Robert J Heine; Lex M Bouter; C D A Stehouwer
Improvement of glycaemic control in type 2 diabetes: favourable changes in blood pressure, total cholesterol and triglycerides, but not in HDL cholesterol, fibrinogen, Von Willebrand factor and (pro)insulin.
The Netherlands journal of medicine 2003;61(4):129-36.
2003: J Hans DeVries; Anders Lindholm; J L Jacobsen; Robert J Heine; Philip Home
A randomized trial of insulin aspart with intensified basal NPH insulin supplementation in people with Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(4):312-8.
2003: R A J M van Dijk; Stephan J L Bakker; Peter G Scheffer; Robert J Heine; C D A Stehouwer
Associations of metabolic variables with arterial stiffness in type 2 diabetes mellitus: focus on insulin sensitivity and postprandial triglyceridaemia.
European journal of clinical investigation 2003;33(4):307-15.
2003: Marcel C Adriaanse; Frank J Snoek; Jacqueline M Dekker; Annemieke M W Spijkerman; Giel Nijpels; Henk M van der Ploeg; Robert J Heine
Perceived risk for Type 2 diabetes in participants in a stepwise population-screening programme.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(3):210-5.
2003: M H A Stehouwer; J Hans DeVries; J A E Lumeij; H J Adèr; A M S Engbers; A van Iperen Av; Frank J Snoek; Robert J Heine
Combined bedtime insulin--daytime sulphonylurea regimen compared with two different daily insulin regimens in type 2 diabetes: effects on HbA1c and hypoglycaemia rate--a randomised trial.
Diabetes/metabolism research and reviews 2003;19(2):148-52.
2003: A Becker; Piet J Kostense; Griët Bos; Robert J Heine; Jacqueline M Dekker; Giel Nijpels; Lex M Bouter; C D A Stehouwer
Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes.
Journal of internal medicine 2003;253(3):293-300.
2003: Hendrik A van Leiden; Jacqueline M Dekker; Annette C Moll; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer; Bettine C P Polak
Risk factors for incident retinopathy in a diabetic and nondiabetic population: the Hoorn study.
Archives of ophthalmology 2003;121(2):245-51.
2003: Michaela Diamant; Robert J Heine
Thiazolidinediones in type 2 diabetes mellitus: current clinical evidence.
Drugs 2003;63(13):1373-405.
2003: Marieke B Snijder; Jacqueline M Dekker; Marjolein Visser; John S Yudkin; Coen D A Stehouwer; Lex M Bouter; Robert J Heine; Giel Nijpels; jacob seidell
Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn study.
Obesity research 2003;11(1):104-11.
2003: A Becker; Yvo M Smulders; Tom Teerlink; Eduard A Struys; Kees de Meer; Piet J Kostense; Cornelis Jakobs; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; C D A Stehouwer
S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations.
European journal of clinical investigation 2003;33(1):17-25.
2002: Annemieke M W Spijkerman; Jacqueline M Dekker; Giel Nijpels; Agnes Jager; Piet J Kostense; Victor W M van Hinsbergh; Lex M Bouter; Robert J Heine; C D A Stehouwer
Impact of diabetes duration and cardiovascular risk factors on mortality in type 2 diabetes: the Hoorn Study.
European journal of clinical investigation 2002;32(12):924-30.
2002: J Hans DeVries; Frank J Snoek; Piet J Kostense; Nathalie Masurel; Robert J Heine
A randomized trial of continuous subcutaneous insulin infusion and intensive injection therapy in type 1 diabetes for patients with long-standing poor glycemic control.
Diabetes care 2002;25(11):2074-80.
2002: Annemieke M W Spijkerman; Marcel C Adriaanse; Jacqueline M Dekker; Giel Nijpels; Coen D A Stehouwer; Lex M Bouter; Robert J Heine
Diabetic patients detected by population-based stepwise screening already have a diabetic cardiovascular risk profile.
Diabetes care 2002;25(10):1784-9.
2002: Leen M 't Hart; Timon W van Haeften; Jacqueline M Dekker; Martine Bot; Robert J Heine; J Antonie Maassen
Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.
Diabetes 2002;51(10):3135-8.
2002: Ronald M A Henry; Piet J Kostense; Griët Bos; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study.
Kidney international 2002;62(4):1402-7.
2002: Lonneke V van de Poll-Franse; Gerlof D Valk; Carry M Renders; Robert J Heine; Jacques Th M van Eijk
Longitudinal assessment of the development of diabetic polyneuropathy and associated risk factors.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(9):771-6.
2002: Miranda T Schram; Piet J Kostense; R A J M van Dijk; Jacqueline M Dekker; Giel Nijpels; Lex M Bouter; Robert J Heine; Coen D Stehouwer
Diabetes, pulse pressure and cardiovascular mortality: the Hoorn Study.
Journal of hypertension 2002;20(9):1743-51.
2002: Hendrik A van Leiden; Jacqueline M Dekker; Annette C Moll; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer; Bettine C P Polak
Blood pressure, lipids, and obesity are associated with retinopathy: the hoorn study.
Diabetes care 2002;25(8):1320-5.
2002: Femmie de Vegt; Jacqueline M Dekker; Willem Jan A Groeneveld; Giel Nijpels; Coen D A Stehouwer; Lex M Bouter; Robert J Heine
Moderate alcohol consumption is associated with lower risk for incident diabetes and mortality: the Hoorn Study.
Diabetes research and clinical practice 2002;57(1):53-60.
2002: J Hans DeVries; S A Eskes; Frank J Snoek; Francois Pouwer; E Van Ballegooie; A J Spijker; Piet J Kostense; M Seubert; Robert J Heine
Continuous intraperitoneal insulin infusion in patients with 'brittle' diabetes: favourable effects on glycaemic control and hospital stay.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(6):496-501.
2002: Marcel C Adriaanse; Frank J Snoek; Jacqueline M Dekker; Henk M van der Ploeg; Robert J Heine
Screening for Type 2 diabetes: an exploration of subjects' perceptions regarding diagnosis and procedure.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(5):406-11.
2002: Robert J Heine; Jacqueline M Dekker
Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease.
Diabetologia 2002;45(4):461-75.
2002: Agnes Jager; Victor W M van Hinsbergh; Piet J Kostense; Jef J Emeis; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
C-reactive protein and soluble vascular cell adhesion molecule-1 are associated with elevated urinary albumin excretion but do not explain its link with cardiovascular risk.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):593-8.
2002: Leen M 't Hart; Giel Nijpels; Jacqueline M Dekker; J Antonie Maassen; Robert J Heine; Timon W van Haeften
Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.
Diabetes 2002;51(3):884-7.
2002: A Becker; Victor W M van Hinsbergh; Agnes Jager; Piet J Kostense; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; C D A Stehouwer
Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality?
European journal of clinical investigation 2002;32(1):1-8.
2001: Peter G Scheffer; Stephan J L Bakker; Corry Popp-Snijders; Robert J Heine; Ruud B H Schutgens; Tom Teerlink
Composition of LDL as determinant of its susceptibility to in vitro oxidation in patients with well-controlled type 2 diabetes.
Diabetes/metabolism research and reviews 2001;17(6):459-66.
2001: ED Mollema; Frank J Snoek; H J Adèr; Robert J Heine; Henk M van der Ploeg
Insulin-treated diabetes patients with fear of self-injecting or fear of self-testing: psychological comorbidity and general well-being.
Journal of psychosomatic research 2001;51(5):665-72.
2001: Frank J Snoek; Nicole C W Van Der Ven; Caroline H C Lubach; M Chatrou; Herman J Adèr; Robert J Heine; A M Jacobson
Effects of cognitive behavioural group training (CBGT) in adult patients with poorly controlled insulin-dependent (type 1) diabetes: a pilot study.
Patient education and counseling 2001;45(2):143-8.
2001: Francois Pouwer; Frank J Snoek; Henk M van der Ploeg; Herman J Adèr; Robert J Heine
Monitoring of psychological well-being in outpatients with diabetes: effects on mood, HbA(1c), and the patient's evaluation of the quality of diabetes care: a randomized controlled trial.
Diabetes care 2001;24(11):1929-35.
2001: J Gerritsen; Jacqueline M Dekker; Ben J TenVoorde; Piet J Kostense; Robert J Heine; Lex M Bouter; Rob M Heethaar; Coen D A Stehouwer
Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study.
Diabetes care 2001;24(10):1793-8.
2001: R A J M van Dijk; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance.
European journal of clinical investigation 2001;31(9):756-63.
2001: ED Mollema; Frank J Snoek; Robert J Heine; Henk M van der Ploeg
Phobia of self-injecting and self-testing in insulin-treated diabetes patients: opportunities for screening.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(8):671-4.
2001: Cees Rustemeijer; JA Schouten; HJ Voerman; A C Beynen; A J Donker; Robert J Heine
Is pseudocholinesterase activity related to markers of triacylglycerol synthesis in Type II diabetes mellitus?
Clinical science (London, England : 1979) 2001;101(1):29-35.
2001: P S van der Wal; Robert J Heine
Characteristics of pancreatic beta-cell secretion in Type 2 diabetic patients treated with gliclazide and glibenclamide.
Diabetes research and clinical practice 2001;52(2):103-11.
2001: Femmie de Vegt; Jacqueline M Dekker; Agnes Jager; E Hienkens; Piet J Kostense; Coen D A Stehouwer; Giel Nijpels; Lex M Bouter; Robert J Heine
Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study.
JAMA : the journal of the American Medical Association 2001;285(16):2109-13.
2001: Agnes Jager; Victor W M van Hinsbergh; Piet J Kostense; Jef J Emeis; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Prognostic implications of retinopathy and a high plasma von Willebrand factor concentration in type 2 diabetic subjects with microalbuminuria.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(3):529-36.
2001: Agnes Jager; Piet J Kostense; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Lex M Bouter; A J M Donker; Coen D A Stehouwer
Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(1):74-81.
2000: EK Hoogeveen; Piet J Kostense; P E Eysink; Bettine C P Polak; P J Beks; Cornelis Jakobs; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study.
Archives of internal medicine 2000;160(19):2984-90.
2000: ED Mollema; Frank J Snoek; Francois Pouwer; Robert J Heine; Henk M van der Ploeg
Diabetes Fear of Injecting and Self-Testing Questionnaire: a psychometric evaluation.
Diabetes care 2000;23(6):765-9.
2000: MM Janssen; Frank J Snoek; R T de Jongh; S Casteleijn; WL Devillé; Robert J Heine
Biological and behavioural determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes on multiple insulin injection therapy.
Diabetes/metabolism research and reviews 2000;16(3):157-63.
2000: J Gerritsen; Jacqueline M Dekker; Ben J TenVoorde; Frits W Bertelsmann; Piet J Kostense; Coen D A Stehouwer; Robert J Heine; Giel Nijpels; Rob M Heethaar; Lex M Bouter
Glucose tolerance and other determinants of cardiovascular autonomic function: the Hoorn Study.
Diabetologia 2000;43(5):561-70.
2000: MM Janssen; Frank J Snoek; Nathalie Masurel; R P Hoogma; WL Devillé; Corry Popp-Snijders; Robert J Heine
Optimized basal-bolus therapy using a fixed mixture of 75% lispro and 25% NPL insulin in type 1 diabetes patients: no favorable effects on glycemic control, physiological responses to hypoglycemia, well-being, or treatment satisfaction.
Diabetes care 2000;23(5):629-33.
2000: EK Hoogeveen; Piet J Kostense; Cornelis Jakobs; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study.
Circulation 2000;101(13):1506-11.
2000: MM Janssen; Frank J Snoek; Robert J Heine
Assessing impaired hypoglycemia awareness in type 1 diabetes: agreement of self-report but not of field study data with the autonomic symptom threshold during experimental hypoglycemia.
Diabetes care 2000;23(4):529-32.
2000: LM Hart; Jacqueline M Dekker; Timon W van Haeften; JB Ruige; C D Stehouwer; D Willem Erkelens; Robert J Heine; J Antonie Maassen
Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.
Diabetologia 2000;43(4):515-9.
2000: EK Hoogeveen; Piet J Kostense; Cornelis Jakobs; Jan A Rauwerda; Jacqueline M Dekker; Giel Nijpels; Lex M Bouter; Robert J Heine; Coen D A Stehouwer
Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: The Hoorn Study.
Journal of internal medicine 2000;247(4):442-8.
2000: Agnes Jager; Victor W M van Hinsbergh; Piet J Kostense; Jef J Emeis; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.
Diabetes 2000;49(3):485-91.
2000: Francois Pouwer; Frank J Snoek; Henk M van der Ploeg; Herman J Adèr; Robert J Heine
The well-being questionnaire: evidence for a three-factor structure with 12 items (W-BQ12).
Psychological medicine 2000;30(2):455-62.
2000: Cees Rustemeijer; JA Schouten; HJ Voerman; H E Hensgens; A J Donker; Robert J Heine
Pravastatin compared to bezafibrate in the treatment of dyslipidemia in insulin-treated patients with type 2 diabetes mellitus.
Diabetes/metabolism research and reviews 2000;16(2):82-7.
2000: R A J M van Dijk; Giel Nijpels; Jos W R Twisk; M Steyn; Jacqueline M Dekker; Robert J Heine; A J M Donker; Coen D A Stehouwer
Change in common carotid artery diameter, distensibility and compliance in subjects with a recent history of impaired glucose tolerance: a 3-year follow-up study.
Journal of hypertension 2000;18(3):293-300.
2000: JM Mooy; H de Vries; PA Grootenhuis; Lex M Bouter; Robert J Heine
Major stressful life events in relation to prevalence of undetected type 2 diabetes: the Hoorn Study.
Diabetes care 2000;23(2):197-201.
2000: Lonneke V van de Poll-Franse; Gerlof D Valk; Jos H M Dekker; Robert J Heine; Jacques Th M van Eijk
'Numbness of the feet' is a poor indicator for polyneuropathy in Type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(2):105-10.
2000: Femmie de Vegt; Jacqueline M Dekker; Coen D A Stehouwer; Giel Nijpels; Lex M Bouter; Robert J Heine
Similar 9-year mortality risks and reproducibility for the World Health Organization and American Diabetes Association glucose tolerance categories: the Hoorn Study.
Diabetes care 2000;23(1):40-4.
2000: Stephan J L Bakker; Richard G IJzerman; Tom Teerlink; H V Westerhoff; Rijk O B Gans; Robert J Heine
Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?
Atherosclerosis 2000;148(1):17-21.
1999: Stephan J L Bakker; Jan C ter Maaten; Corry Popp-Snijders; Robert J Heine; Rijk O B Gans
Triiodothyronine: a link between the insulin resistance syndrome and blood pressure?
Journal of hypertension 1999;17(12 Pt 1):1725-30.
1999: Robert J Heine
Diabetes in the next century: challenges and opportunities.
The Netherlands journal of medicine 1999;55(6):265-70.
1999: EK Hoogeveen; Piet J Kostense; Gerlof D Valk; Frits W Bertelsmann; Cornelis Jakobs; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Hyperhomocysteinaemia is not related to risk of distal somatic polyneuropathy: the Hoorn Study.
Journal of internal medicine 1999;246(6):561-6.
1999: Agnes Jager; Victor W M van Hinsbergh; Piet J Kostense; Jef J Emeis; J S Yudkin; Giel Nijpels; Jacqueline M Dekker; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic subjects: the Hoorn Study.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):3071-8.
1999: Francois Pouwer; Henk M van der Ploeg; Herman J Adèr; Robert J Heine; Frank J Snoek
The 12-item well-being questionnaire. An evaluation of its validity and reliability in Dutch people with diabetes.
Diabetes care 1999;22(12):2004-10.
1999: Margriet Bouma; Jos H M Dekker; Jacques Th M van Eijk; François G Schellevis; Didi M W Kriegsman; Robert J Heine
Metabolic control and morbidity of type 2 diabetic patients in a general practice network.
Family practice 1999;16(4):402-6.
1999: Femmie de Vegt; Jacqueline M Dekker; H G Ruhé; Coen D A Stehouwer; Giel Nijpels; Lex M Bouter; Robert J Heine
Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study.
Diabetologia 1999;42(8):926-31.
1999: JB Ruige; Jacqueline M Dekker; Werner Blum; Coen D A Stehouwer; Giel Nijpels; JM Mooy; Piet J Kostense; Lex M Bouter; Robert J Heine
Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study.
Diabetes care 1999;22(7):1097-104.
1999: Robert J Heine
Current therapeutic options in type 2 diabetes.
European journal of clinical investigation 1999;29 Suppl 2():17-20.
1999: Margriet Bouma; Jos H M Dekker; J J J de Sonnaville; F E E van der Does; H de Vries; Didi M W Kriegsman; Piet J Kostense; Robert J Heine; Jacques Th M van Eijk
How valid is fasting plasma glucose as a parameter of glycemic control in non-insulin-using patients with type 2 diabetes?
Diabetes care 1999;22(6):904-7.
1999: LM Hart; P de Knijff; Jacqueline M Dekker; R P Stolk; Giel Nijpels; F E van der Does; JB Ruige; Diederick Grobbee; Robert J Heine; J Antonie Maassen
Variants in the sulphonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians.
Diabetologia 1999;42(5):617-20.
1999: L M t Hart; JB Ruige; Jacqueline M Dekker; C D Stehouwer; J Antonie Maassen; Robert J Heine
Altered beta-cell characteristics in impaired glucose tolerant carriers of a GAA trinucleotide repeat polymorphism in the frataxin gene.
Diabetes 1999;48(4):924-6.
1999: LM Hart; R P Stolk; Jacqueline M Dekker; Giel Nijpels; Diederick Grobbee; Robert J Heine; J Antonie Maassen
Prevalence of variants in candidate genes for type 2 diabetes mellitus in The Netherlands: the Rotterdam study and the Hoorn study.
The Journal of clinical endocrinology and metabolism 1999;84(3):1002-6.
1999: Agnes Jager; Piet J Kostense; H G Ruhé; Robert J Heine; Giel Nijpels; Jacqueline M Dekker; Lex M Bouter; Coen D A Stehouwer
Microalbuminuria and peripheral arterial disease are independent predictors of cardiovascular and all-cause mortality, especially among hypertensive subjects: five-year follow-up of the Hoorn Study.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):617-24.
1999: C A Baan; JB Ruige; Ronald P Stolk; Jacqueline C M Witteman; Jacqueline M Dekker; Robert J Heine; E J Feskens
Performance of a predictive model to identify undiagnosed diabetes in a health care setting.
Diabetes care 1999;22(2):213-9.
1999: JB Ruige; Jacqueline M Dekker; Giel Nijpels; Corry Popp-Snijders; Coen D A Stehouwer; Piet J Kostense; Lex M Bouter; Robert J Heine
Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose.
Diabetologia 1999;42(2):177-80.
1998: F E E van der Does; JN de Neeling; Frank J Snoek; PA Grootenhuis; Piet J Kostense; Lex M Bouter; Robert J Heine
Randomized study of two different target levels of glycemic control within the acceptable range in type 2 diabetes. Effects on well-being at 1 year.
Diabetes care 1998;21(12):2085-93.
1998: Stephan J L Bakker; Jacqueline M Dekker; Robert J Heine
Association between HbA1c and HDL-cholesterol independent of fasting triglycerides in a Caucasian population: evidence for enhanced cholesterol ester transfer induced by in vivo glycation.
Diabetologia 1998;41(10):1249-50.
1998: Stephan J L Bakker; EK Hoogeveen; Giel Nijpels; Piet J Kostense; Jacqueline M Dekker; Rijk O B Gans; Robert J Heine
The association of dietary fibres with glucose tolerance is partly explained by concomitant intake of thiamine: the Hoorn Study.
Diabetologia 1998;41(10):1168-75.
1998: Femmie de Vegt; Jacqueline M Dekker; Coen D A Stehouwer; Giel Nijpels; Lex M Bouter; Robert J Heine
The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study.
Diabetes care 1998;21(10):1686-90.
1998: EK Hoogeveen; Piet J Kostense; Agnes Jager; Robert J Heine; Cornelis Jakobs; Lex M Bouter; A J M Donker; Coen D A Stehouwer
Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn Study.
Kidney international 1998;54(1):203-9.
1998: Agnes Jager; Piet J Kostense; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer
Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study.
Diabetologia 1998;41(6):694-700.
1998: J J J de Sonnaville; Frank J Snoek; LP Colly; WL Devillé; D Wijkel; Robert J Heine
Well-being and symptoms in relation to insulin therapy in type 2 diabetes.
Diabetes care 1998;21(6):919-24.
1998: PA Grootenhuis; JM Mooy; Piet J Kostense; Corry Popp-Snijders; Lex M Bouter; Robert J Heine
Dissimilar association of conventional immuno-reactive versus specific insulin with cardiovascular risk factors: a consequence of proinsulinaemia?
Diabetes research and clinical practice 1998;40(2):81-90.
1998: C E Friedberg; MJ Janssen; Robert J Heine; Diederick Grobbee
Fish oil and glycemic control in diabetes. A meta-analysis.
Diabetes care 1998;21(4):494-500.
1998: JB Ruige; W J Assendelft; Jacqueline M Dekker; Piet J Kostense; Robert J Heine; Lex M Bouter
Insulin and risk of cardiovascular disease: a meta-analysis.
Circulation 1998;97(10):996-1001.
1998: K Kanc; MM Janssen; E T Keulen; MA Jacobs; Corry Popp-Snijders; Frank J Snoek; Robert J Heine
Substitution of night-time continuous subcutaneous insulin infusion therapy for bedtime NPH insulin in a multiple injection regimen improves counterregulatory hormonal responses and warning symptoms of hypoglycaemia in IDDM.
Diabetologia 1998;41(3):322-9.
1998: Francois Pouwer; Frank J Snoek; Henk M van der Ploeg; Robert J Heine; A N Brand
A comparison of the standard and the computerized versions of the Well-being Questionnaire (WBQ) and the Diabetes Treatment Satisfaction Questionnaire (DTSQ).
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 1998;7(1):33-8.
1998: JM Mooy; PA Grootenhuis; H de Vries; Lex M Bouter; Piet J Kostense; Robert J Heine
Determinants of specific serum insulin concentrations in a general Caucasian population aged 50 to 74 years (the Hoorn Study).
Diabetic medicine : a journal of the British Diabetic Association 1998;15(1):45-52.
1998: EK Hoogeveen; Piet J Kostense; P J Beks; Albert J C Mackaay; Cornelis Jakobs; Lex M Bouter; Robert J Heine; Coen D A Stehouwer
Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(1):133-8.
1997: MM Janssen; S Casteleijn; WL Devillé; Corry Popp-Snijders; P Roach; Robert J Heine
Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation.
Diabetes care 1997;20(12):1870-3.
1997: EK Hoogeveen; Piet J Kostense; Cornelis Jakobs; Lex M Bouter; Robert J Heine; Coen D A Stehouwer
Does metformin increase the serum total homocysteine level in non-insulin-dependent diabetes mellitus?
Journal of internal medicine 1997;242(5):389-94.
1997: J J J de Sonnaville; Margriet Bouma; LP Colly; WL Devillé; D Wijkel; Robert J Heine
Sustained good glycaemic control in NIDDM patients by implementation of structured care in general practice: 2-year follow-up study.
Diabetologia 1997;40(11):1334-40.
1997: Frank J Snoek; ED Mollema; Robert J Heine; Lex M Bouter; Henk M van der Ploeg
Development and validation of the diabetes fear of injecting and self-testing questionnaire (D-FISQ): first findings.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(10):871-6.
1997: Giel Nijpels; Corry Popp-Snijders; Piet J Kostense; Lex M Bouter; Robert J Heine
Cardiovascular risk factors prior to the development of non-insulin-dependent diabetes mellitus in persons with impaired glucose tolerance: the Hoorn Study.
Journal of clinical epidemiology 1997;50(9):1003-9.
1997: MA Jacobs; E T Keulen; K Kanc; S Casteleijn; Peter G Scheffer; WL Devillé; Robert J Heine
Metabolic efficacy of preprandial administration of Lys(B28), Pro(B29) human insulin analog in IDDM patients. A comparison with human regular insulin during a three-meal test period.
Diabetes care 1997;20(8):1279-86.
1997: JB Ruige; Manou R Batstra; Henk-Jan Aanstoot; Lex M Bouter; G Jan Bruining; JN de Neeling; Robert J Heine
Low prevalence of antibodies to GAD65 in a 50- to 74-year-old general Dutch population. The Hoorn Study.
Diabetes care 1997;20(7):1108-10.
1997: Stephan J L Bakker; Robert J Heine; R O Gans
Thiamine may indirectly act as an antioxidant.
Diabetologia 1997;40(6):741-2.
1997: JB Ruige; JN de Neeling; Piet J Kostense; Lex M Bouter; Robert J Heine
Performance of an NIDDM screening questionnaire based on symptoms and risk factors.
Diabetes care 1997;20(4):491-6.
1997: J J J de Sonnaville; LP Colly; D Wijkel; Robert J Heine
The prevalence and determinants of foot ulceration in type II diabetic patients in a primary health care setting.
Diabetes research and clinical practice 1997;35(2-3):149-56.
1997: MA Jacobs; B Salobir; Corry Popp-Snijders; H Ader; Robert J Heine
Counterregulatory hormone responses and symptoms during hypoglycaemia induced by porcine, human regular insulin, and Lys(B28), Pro(B29) human insulin analogue (insulin Lispro) in healthy male volunteers.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(3):248-57.
1997: P H Beks; Albert J C Mackaay; H de Vries; JN de Neeling; Lex M Bouter; Robert J Heine
Carotid artery stenosis is related to blood glucose level in an elderly Caucasian population: the Hoorn Study.
Diabetologia 1997;40(3):290-8.
1997: Jan C ter Maaten; A Voorburg; Robert J Heine; Piet M ter Wee; A J M Donker; Rijk O B Gans
Renal handling of urate and sodium during acute physiological hyperinsulinaemia in healthy subjects.
Clinical science (London, England : 1979) 1997;92(1):51-8.
1996: E D Mollem; Frank J Snoek; Robert J Heine
Assessment of perceived barriers in self-care of insulin-requiring diabetic patients.
Patient education and counseling 1996;29(3):277-81.
1996: JN de Neeling; P J Beks; Frits W Bertelsmann; Robert J Heine; L M Bouter
Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: the Hoorn study.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(11):960-6.
1996: LM Hart; R P Stolk; Robert J Heine; Diederick Grobbee; F E van der Does; J Antonie Maassen
Association of the insulin-receptor variant Met-985 with hyperglycemia and non-insulin-dependent diabetes mellitus in the Netherlands: a population-based study.
American journal of human genetics 1996;59(5):1119-25.
1996: M A Merbis; Frank J Snoek; K Kanc; Robert J Heine
Hypoglycaemia induces emotional disruption.
Patient education and counseling 1996;29(1):117-22.
1996: Robert J Heine
Role of sulfonylureas in non-insulin-dependent diabetes mellitus: Part II--"The cons".
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(9):522-6.
1996: J J J de Sonnaville; D van der Feltz van der Sloot; L Ernst; D Wijkel; Robert J Heine
Retinopathy screening in type 2 diabetes: reliability of wide angle fundus photography.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(5):482-6.
1996: K H Polderman; Louis J G Gooren; Robert J Heine
Effects of physiological and supraphysiological doses of insulin on adrenal androgen levels.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(3):152-5.
1996: F E Van der Does; JN de Neeling; Frank J Snoek; Piet J Kostense; PA Grootenhuis; L M Bouter; Robert J Heine
Symptoms and well-being in relation to glycemic control in type II diabetes.
Diabetes care 1996;19(3):204-10.
1996: JM Mooy; PA Grootenhuis; H de Vries; Piet J Kostense; Corry Popp-Snijders; L M Bouter; Robert J Heine
Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study.
Diabetologia 1996;39(3):298-305.
1996: Robert J Heine; JM Mooy
Impaired glucose tolerance and unidentified diabetes.
Postgraduate medical journal 1996;72(844):67-71.
1996: Giel Nijpels; Corry Popp-Snijders; Piet J Kostense; L M Bouter; Robert J Heine
Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study.
Diabetologia 1996;39(1):113-8.
1996: Robert J Heine; Giel Nijpels; JM Mooy
New data on the rate of progression of impaired glucose tolerance to NIDDM and predicting factors.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(3 Suppl 2):S12-4.
1995: JM Mooy; PA Grootenhuis; H de Vries; H A Valkenburg; L M Bouter; Piet J Kostense; Robert J Heine
Prevalence and determinants of glucose intolerance in a Dutch caucasian population. The Hoorn Study.
Diabetes care 1995;18(9):1270-3.
1995: P J Beks; Albert J C Mackaay; JN de Neeling; H de Vries; L M Bouter; Robert J Heine
Peripheral arterial disease in relation to glycaemic level in an elderly Caucasian population: the Hoorn study.
Diabetologia 1995;38(1):86-96.
1994: Giel Nijpels; P S van der Wal; L M Bouter; Robert J Heine
Comparison of three methods for the quantification of beta-cell function and insulin sensitivity.
Diabetes research and clinical practice 1994;26(3):189-95.
1994: L M t Hart; Herman H P J Lemkes; Robert J Heine; R P Stolk; E J Feskens; J J Jansen; F E van der Does; Diederick Grobbee; D Kromhout; J M W van den Ouweland
Prevalence of maternally inherited diabetes and deafness in diabetic populations in The Netherlands.
Diabetologia 1994;37(11):1169-70.
1994: K H Polderman; Louis J G Gooren; Henk Asscheman; A Bakker; Robert J Heine
Induction of insulin resistance by androgens and estrogens.
The Journal of clinical endocrinology and metabolism 1994;79(1):265-71.
1994: M C Blonk; M A Jacobs; E H Biesheuvel; W L Weeda-Mannak; Robert J Heine
Influences on weight loss in type 2 diabetic patients: little long-term benefit from group behaviour therapy and exercise training.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(5):449-57.
1994: JN de Neeling; P J Beks; Frits W Bertelsmann; Robert J Heine; L M Bouter
Sensory thresholds in older adults: reproducibility and reference values.
Muscle & nerve 1994;17(4):454-61.
1994: M C Blonk; M A Jacobs; C E Friedberg; J J Nauta; T Teerlink; C Popp-Snijders; Robert J Heine
Determinants of insulin sensitivity and consequences for lipoproteins and blood pressure in subjects with non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1994;43(4):501-8.
1994: PA Grootenhuis; Frank J Snoek; Robert J Heine; L M Bouter
Development of a type 2 diabetes symptom checklist: a measure of symptom severity.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(3):253-61.
1993: M A Jacobs; R H Schreuder; K Jap-A-Joe; J J Nauta; P M Andersen; Robert J Heine
The pharmacodynamics and activity of intranasally administered insulin in healthy male volunteers.
Diabetes 1993;42(11):1649-55.
1993: Robert J Heine
Dietary fish oil and insulin action in humans.
Annals of the New York Academy of Sciences 1993;683():110-21.
1992: P J Wahab; A W Rijnsburger; M Oolbekkink; Robert J Heine
Venous versus arterialised venous blood for assessment of blood glucose levels during glucose clamping: comparison in healthy men.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(12):576-9.
1991: Robert J Heine
Non-insulin dependent diabetes mellitus: a phenomenon of ageing?
International journal of epidemiology 1991;20 Suppl 1():S18-24.
1989: Robert J Heine; E A van der Heyden; E A van der Veen
Responses to human and porcine insulin in healthy subjects.
Lancet 1989;2(8669):946-9.
1989: C M Houtzagers; A P Visser; P A Berntzen; H van der Stap; W W van Maarschalkerweerd; Robert J Heine; E A van der Veen
Multiple daily insulin injections improve self-confidence.
Diabetic medicine : a journal of the British Diabetic Association 1989;6(6):512-9.
1989: C M Houtzagers; P A Berntzen; H van der Stap; W W van Maarschalkerweerd; P Lanting; I Boen-Tan; Robert J Heine; E A van der Veen
Efficacy and acceptance of two intensified conventional insulin therapy regimens: a long-term cross-over comparison.
Diabetic medicine : a journal of the British Diabetic Association 1989;6(5):416-21.
1989: Robert J Heine; C Mulder; C Popp-Snijders; J van der Meer; E A van der Veen
Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients.
The American journal of clinical nutrition 1989;49(3):448-56.
1988: C M Houtzagers; P A Berntzen; H van der Stap; Robert J Heine; E A van der Veen
Absorption kinetics of short- and intermediate-acting insulins after jet injection with Medi-Jector II.
Diabetes care 1988;11(9):739-42.
1988: C M Houtzagers; A P Visser; P A Berntzen; Robert J Heine; E A van der Veen
The Medi-Jector II: efficacy and acceptability in insulin-dependent diabetic patients with and without needle phobia.
Diabetic medicine : a journal of the British Diabetic Association 1988;5(2):135-8.