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Peter Heinrich

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Physiology

Signal Transduction

Anatomy

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Co-Publications
Name
44
Müller-Newen, Gerhard
42
Graeve, Lutz
39
Behrmann, Iris
38
Rose-John, Stefan
34
Schaper, Fred
25
Haan, Serge
22
Hermanns, Heike
19
Andus, Tilo
18
Grötzinger, Joachim
16
Horn, Friedemann
15
Haan, Claude
13
Küster, Andrea
12
Radtke, Simone
11
Gross, Volker
11
Gatsios, P

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Publications

TOP 3
Bender Herdis; Wiesinger Monique Y; Nordhoff Carolin; Schoenherr Caroline; Haan Claude; Ludwig Stephan; Weiskirchen Ralf; Kato Nobuyuki; Heinrich Peter C; Haan Serge
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Wiesinger Monique Y; Haan Serge; Wüller Stefan; Kauffmann Maria-Elisabeth; Recker Tobias; Küster Andrea; Heinrich Peter C; Müller-Newen Gerhard
Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).
Hintzen Christoph; Quaiser Saskia; Pap Thomas; Heinrich Peter C; Hermanns Heike M
Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.

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All Publications

2009: Bender Herdis; Wiesinger Monique Y; Nordhoff Carolin; Schoenherr Caroline; Haan Claude; Ludwig Stephan; Weiskirchen Ralf; Kato Nobuyuki; Heinrich Peter C; Haan Serge
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Hepatology (Baltimore, Md.) 2009;50(2):585-91.
2009: Wiesinger Monique Y; Haan Serge; Wüller Stefan; Kauffmann Maria-Elisabeth; Recker Tobias; Küster Andrea; Heinrich Peter C; Müller-Newen Gerhard
Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).
Chemistry & biology 2009;16(7):783-94.
2009: Hintzen Christoph; Quaiser Saskia; Pap Thomas; Heinrich Peter C; Hermanns Heike M
Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis.
Arthritis and rheumatism 2009;60(7):1932-43.
2009: Haan Claude; Kroy Daniela C; Wüller Stefan; Sommer Ulrike; Nöcker Tanja; Rolvering Catherine; Behrmann Iris; Heinrich Peter C; Haan Serge
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2969-77.
2008: Hintzen Christoph; Haan Claude; Tuckermann Jan P; Heinrich Peter C; Hermanns Heike M
Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7341-9.
2008: Sobota Radoslaw M; Müller Pia J; Khouri Christina; Ullrich Axel; Poli Valeria; Noguchi Tetsuya; Heinrich Peter C; Schaper Fred
SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.
Cellular signalling 2008;20(7):1385-91.
2008: Hintzen Christoph; Evers Christina; Lippok Barbara E; Volkmer Rudolf; Heinrich Peter C; Radtke Simone; Hermanns Heike M
Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.
The Journal of biological chemistry 2008;283(28):19465-77.
2008: Sobota Radoslaw M; Müller Pia J; Heinrich Peter C; Schaper Fred
Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation.
The Biochemical journal 2008;412(1):65-72.
2008: Metz Silke; Naeth Gudrun; Heinrich Peter C; Müller-Newen Gerhard
Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors.
The Journal of biological chemistry 2008;283(10):5985-95.
2008: Haan Serge; Margue Christiane; Engrand Arnaud; Rolvering Catherine; Schmitz-Van de Leur Hildegard; Heinrich Peter C; Behrmann Iris; Haan Claude
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):998-1007.
2007: Kreis Stephanie; Munz Georg A; Haan Serge; Heinrich Peter C; Behrmann Iris
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.
Molecular cancer research : MCR 2007;5(12):1331-41.
2007: Herrmann Andreas; Vogt Michael; Mönnigmann Martin; Clahsen Thomas; Sommer Ulrike; Haan Serge; Poli Valeria; Heinrich Peter C; Müller-Newen Gerhard
Nucleocytoplasmic shuttling of persistently activated STAT3.
Journal of cell science 2007;120(Pt 18):3249-61.
2007: Komyod Waraporn; Böhm Markus; Metze Dieter; Heinrich Peter C; Behrmann Iris
Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line.
Molecular cancer research : MCR 2007;5(3):271-81.
2007: Metz Silke; Wiesinger Monique; Vogt Michael; Lauks Heike; Schmalzing Günther; Heinrich Peter C; Müller-Newen Gerhard
Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.
The Journal of biological chemistry 2007;282(2):1238-48.
2006: Neis Mark M; Peters Bettina; Dreuw Alexandra; Wenzel Joerg; Bieber Thomas; Mauch Cornelia; Krieg Thomas; Stanzel Sven; Heinrich Peter C; Merk Hans F; Bosio Andreas; Baron Jens M; Hermanns Heike M
Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis.
The Journal of allergy and clinical immunology 2006;118(4):930-7.
2006: Stross Claudia; Radtke Simone; Clahsen Thomas; Gerlach Christa; Volkmer-Engert Rudolf; Schaper Fred; Heinrich Peter C; Hermanns Heike M
Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.
The Journal of biological chemistry 2006;281(13):8458-68.
2006: Radtke Simone; Jörissen Angela; de Leur Hildegard Schmitz-Van; Heinrich Peter C; Behrmann Iris
Three dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase.
The Journal of biological chemistry 2006;281(7):4024-34.
2006: Böing Irene; Stross Claudia; Radtke Simone; Lippok Barbara E; Heinrich Peter C; Hermanns Heike M
Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases.
Cellular signalling 2006;18(1):50-61.
2006: Lehmann Ute; Sommer Ulrike; Smyczek Tanya; Hörtner Michael; Frisch Wiltrud; Volkmer-Engert Rudolf; Heinrich Peter C; Schaper Fred; Haan Serge
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.
Cellular signalling 2006;18(1):40-9.
2005: Haan Serge; Keller Julia F; Behrmann Iris; Heinrich Peter C; Haan Claude
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.
Cellular signalling 2005;17(12):1542-50.
2005: Giese Bernd; Roderburg Christoph; Sommerauer Michael; Wortmann Saskia B; Metz Silke; Heinrich Peter C; Müller-Newen Gerhard
Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells.
Journal of cell science 2005;118(Pt 21):5129-40.
2005: Costa-Pereira Ana P; Hermanns Heike M; Is'harc Hayaatun; Williams Timothy M; Watling Diane; Arulampalam Velmurugesan; Newman Sally J; Heinrich Peter C; Kerr Ian M
Signaling through a mutant IFN-gamma receptor.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5958-65.
2005: Yang Xiang-Ping; Schaper Fred; Teubner Andreas; Lammert Frank; Heinrich Peter C; Matern Siegfried; Siewert Elmar
Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo.
Journal of hepatology 2005;43(4):704-10.
2005: Wellbrock Claudia; Weisser Christin; Hassel Jessica C; Fischer Petra; Becker Jürgen; Vetter Claudia S; Behrmann Iris; Kortylewski Marcin; Heinrich Peter C; Schartl Manfred
STAT5 contributes to interferon resistance of melanoma cells.
Current biology : CB 2005;15(18):1629-39.
2005: Sommer Ulrike; Schmid Christine; Sobota Radoslaw M; Lehmann Ute; Stevenson Nigel J; Johnston James A; Schaper Fred; Heinrich Peter C; Haan Serge
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
The Journal of biological chemistry 2005;280(36):31478-88.
2005: Radtke Simone; Haan Serge; Jörissen Angela; Hermanns Heike M; Diefenbach Sandra; Smyczek Tanya; Schmitz-Vandeleur Hildegard; Heinrich Peter C; Behrmann Iris; Haan Claude
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.
The Journal of biological chemistry 2005;280(27):25760-8.
2005: Hermanns Heike M; Müller-Newen Gerhard; Heinrich Peter C; Haan Serge
Bow to your partner for signaling.
Nature structural & molecular biology 2005;12(6):476-8.
2005: Komyod Waraporn; Bauer Uta-Maria; Heinrich Peter C; Haan Serge; Behrmann Iris
Are STATS arginine-methylated?
The Journal of biological chemistry 2005;280(23):21700-5.
2005: Clahsen Thomas; Lehmann Ute; Stross Claudia; Hermanns Heike M; Volkmer-Engert Rudolf; Schneider-Mergener Jens; Heinrich Peter C; Schaper Fred
The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.
Cellular signalling 2005;17(5):559-69.
2005: Dreuw Alexandra; Hermanns Heike M; Heise Ruth; Joussen Sylvia; Rodríguez Felipe; Marquardt Yvonne; Jugert Frank; Merk Hans F; Heinrich Peter C; Baron Jens M
Interleukin-6-type cytokines upregulate expression of multidrug resistance-associated proteins in NHEK and dermal fibroblasts.
The Journal of investigative dermatology 2005;124(1):28-37.
2004: von Rango U; Alfer J; Kertschanska S; Kemp B; Müller-Newen G; Heinrich P C; Beier H M; Classen-Linke I
Interleukin-11 expression: its significance in eutopic and ectopic human implantation.
Molecular human reproduction 2004;10(11):783-92.
2004: Selander Katri S; Li Li; Watson Latania; Merrell Melinda; Dahmen Heike; Heinrich Peter C; Müller-Newen Gerhard; Harris Kevin W
Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy.
Cancer research 2004;64(19):6924-33.
2004: Weissenbach Manuela; Clahsen Thomas; Weber Christian; Spitzer Dirk; Wirth Dagmar; Vestweber Dietmar; Heinrich Peter C; Schaper Fred
Interleukin-6 is a direct mediator of T cell migration.
European journal of immunology 2004;34(10):2895-906.
2004: Yang Xiang-Ping; Albrecht Ute; Zakowski Vera; Sobota Radoslaw M; Häussinger Dieter; Heinrich Peter C; Ludwig Stephan; Bode Johannes G; Schaper Fred
Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression.
The Journal of biological chemistry 2004;279(43):45279-89.
2004: Stevenson Nigel J; Haan Serge; McClurg Angela E; McGrattan Michael J; Armstrong Marilyn A; Heinrich Peter C; Johnston James A
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3243-9.
2004: Siewert Elmar; Dietrich Christoph G; Lammert Frank; Heinrich Peter C; Matern Siegfried; Gartung Carsten; Geier Andreas
Interleukin-6 regulates hepatic transporters during acute-phase response.
Biochemical and biophysical research communications 2004;322(1):232-8.
2004: Dreuw Alexandra; Radtke Simone; Pflanz Stefan; Lippok Barbara E; Heinrich Peter C; Hermanns Heike M
Characterization of the signaling capacities of the novel gp130-like cytokine receptor.
The Journal of biological chemistry 2004;279(34):36112-20.
2004: Behrmann Iris; Smyczek Tanja; Heinrich Peter C; Schmitz-Van de Leur Hildegard; Komyod Waraporn; Giese Bernd; Müller-Newen Gerhard; Haan Serge; Haan Claude
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.
The Journal of biological chemistry 2004;279(34):35486-93.
2004: Classen-Linke I; Müller-Newen G; Heinrich P C; Beier H M; von Rango U
The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua.
Molecular human reproduction 2004;10(7):495-504.
2004: Pranada Albert L; Metz Silke; Herrmann Andreas; Heinrich Peter C; Müller-Newen Gerhard
Real time analysis of STAT3 nucleocytoplasmic shuttling.
The Journal of biological chemistry 2004;279(15):15114-23.
2004: Fischer Patrick; Lehmann Ute; Sobota Radoslaw M; Schmitz Jochen; Niemand Claudia; Linnemann Sonja; Haan Serge; Behrmann Iris; Yoshimura Akihiko; Johnston James A; Müller-Newen Gerhard; Heinrich Peter C; Schaper Fred
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
The Biochemical journal 2004;378(Pt 2):449-60.
2004: Kortylewski Marcin; Komyod Waraporn; Kauffmann Maria-Elisabeth; Bosserhoff Anja; Heinrich Peter C; Behrmann Iris
Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals.
The Journal of investigative dermatology 2004;122(2):414-22.
2004: Herrmann Andreas; Sommer Ulrike; Pranada Albert L; Giese Bernd; Küster Andrea; Haan Serge; Becker W; Heinrich Peter C; Müller-Newen Gerhard
STAT3 is enriched in nuclear bodies.
Journal of cell science 2004;117(Pt 2):339-49.
2003: Giese Bernd; Au-Yeung Chi-King; Herrmann Andreas; Diefenbach Sandra; Haan Claude; Küster Andrea; Wortmann Saskia B; Roderburg Christoph; Heinrich Peter C; Behrmann Iris; Müller-Newen Gerhard
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.
The Journal of biological chemistry 2003;278(40):39205-13.
2003: Behrmann Iris; Wallner Susanne; Komyod Waraporn; Heinrich Peter C; Schuierer Marion; Buettner Reinhard; Bosserhoff Anja-Katrin
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.
The American journal of pathology 2003;163(2):683-90.
2003: Haan Serge; Ferguson Paul; Sommer Ulrike; Hiremath Meena; McVicar Daniel W; Heinrich Peter C; Johnston James A; Cacalano Nicholas A
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
The Journal of biological chemistry 2003;278(34):31972-9.
2003: Heinrich Peter C; Behrmann Iris; Haan Serge; Hermanns Heike M; Müller-Newen Gerhard; Schaper Fred
Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
The Biochemical journal 2003;374(Pt 1):1-20.
2003: Ancey Cécile; Küster Andrea; Haan Serge; Herrmann Andreas; Heinrich Peter C; Müller-Newen Gerhard
A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.
The Journal of biological chemistry 2003;278(19):16968-72.
2003: Niemand Claudia; Nimmesgern Ariane; Haan Serge; Fischer Patrick; Schaper Fred; Rossaint Rolf; Heinrich Peter C; Müller-Newen Gerhard
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3263-72.
2003: Kortylewski Marcin; Feld Florian; Krüger Klaus-Dieter; Bahrenberg Gregor; Roth Richard A; Joost Hans-Georg; Heinrich Peter C; Behrmann Iris; Barthel Andreas
Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism.
The Journal of biological chemistry 2003;278(7):5242-9.
2003: Lehmann Ute; Schmitz Jochen; Weissenbach Manuela; Sobota Radoslaw M; Hortner Michael; Friederichs Kerstin; Behrmann Iris; Tsiaris William; Sasaki Atsuo; Schneider-Mergener Jens; Yoshimura Akihiko; Neel Benjamin G; Heinrich Peter C; Schaper Fred
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
The Journal of biological chemistry 2003;278(1):661-71.
2003: May Petra; Schniertshauer Ute; Gerhartz Claudia; Horn Friedemann; Heinrich Peter C
Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation.
Acta biochimica Polonica 2003;50(3):595-601.
2002: Hörtner Michael; Nielsch Ulrich; Mayr Lorenz M; Johnston James A; Heinrich Peter C; Haan Serge
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1219-27.
2002: Greiser Jens S; Stross Claudia; Heinrich Peter C; Behrmann Iris; Hermanns Heike M
Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.
The Journal of biological chemistry 2002;277(30):26959-65.
2002: Timmermann Andreas; Küster Andrea; Kurth Ingo; Heinrich Peter C; Müller-Newen Gerhard
A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor.
European journal of biochemistry / FEBS 2002;269(11):2716-26.
2002: Hörtner Michael; Nielsch Ulrich; Mayr Lorenz M; Heinrich Peter C; Haan Serge
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
European journal of biochemistry / FEBS 2002;269(10):2516-26.
2002: Bahrenberg Gregor; Behrmann Iris; Barthel Andreas; Hekerman Paul; Heinrich Peter Claus; Joost Hans-Georg; Becker Walter
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):859-72.
2002: En-Nia Abdelaziz; Reisdorff Julia; Stefanidis Ioannis; Floege Juergen; Heinrich Peter C; Mertens Peter R
Mesangial cell gelatinase A synthesis is attenuated by oscillating hyperbaric pressure.
The Biochemical journal 2002;362(Pt 3):693-700.
2002: Radtke Simone; Hermanns Heike M; Haan Claude; Schmitz-Van De Leur Hildegard; Gascan Hugues; Heinrich Peter C; Behrmann Iris
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.
The Journal of biological chemistry 2002;277(13):11297-305.
2002: Haan Claude; Heinrich Peter C; Behrmann Iris
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.
The Biochemical journal 2002;361(Pt 1):105-11.
2001: Friederichs K; Schmitz J; Weissenbach M; Heinrich P C; Schaper F
Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.
European journal of biochemistry / FEBS 2001;268(24):6401-7.
2001: Terstegen L; Gatsios P; Ludwig S; Pleschka S; Jahnen-Dechent W; Heinrich P C; Graeve L
The vesicular stomatitis virus matrix protein inhibits glycoprotein 130-dependent STAT activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5209-16.
2001: Strobl B; Arulampalam V; Is'harc H; Newman S J; Schlaak J F; Watling D; Costa-Pereira A P; Schaper F; Behrmann I; Sheehan K C; Schreiber R D; Horn F; Heinrich P C; Kerr I M
A completely foreign receptor can mediate an interferon-gamma-like response.
The EMBO journal 2001;20(19):5431-42.
2001: Haan C; Is'harc H; Hermanns H M; Schmitz-Van De Leur H; Kerr I M; Heinrich P C; Grötzinger J; Behrmann I
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction.
The Journal of biological chemistry 2001;276(40):37451-8.
2001: Bode J G; Fischer R; Häussinger D; Graeve L; Heinrich P C; Schaper F
The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1469-81.
2001: Böhm M; Schulte U; Funk J O; Raghunath M; Behrmann I; Kortylewski M; Heinrich P C; Kues T; Luger T A; Schwarz T
Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity.
The Journal of investigative dermatology 2001;117(1):132-40.
2001: Kortylewski M; Heinrich P C; Kauffmann M E; Böhm M; MacKiewicz A; Behrmann I
Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells.
The Biochemical journal 2001;357(Pt 1):297-303.
2001: Pflanz S; Kernebeck T; Giese B; Herrmann A; Pachta-Nick M; Stahl J; Wollmer A; Heinrich P C; Müller-Newen G; Grötzinger J
Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential.
The Biochemical journal 2001;356(Pt 2):605-12.
2001: Schleinkofer K; Dingley A; Tacken I; Federwisch M; Müller-Newen G; Heinrich P C; Vusio P; Jacques Y; Grötzinger J
Identification of the domain in the human interleukin-11 receptor that mediates ligand binding.
Journal of molecular biology 2001;306(2):263-74.
2001: Kortylewski M; Heinrich P C; Mackiewicz A; Behrmann I
Cytokine-mediated growth inhibition of human melanoma cells.
Advances in experimental medicine and biology 2001;495():169-72.
2001: Heinrich P C; Bode J; Decker M; Graeve L; Martens A; Müller-Newen G; Pflanz S; Schaper F; Schmitz J
Termination and modulation of IL-6-type cytokine signaling.
Advances in experimental medicine and biology 2001;495():153-60.
2000: Pflanz S; Kurth I; Grötzinger J; Heinrich P C; Müller-Newen G
Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7042-9.
2000: Hermanns H M; Radtke S; Schaper F; Heinrich P C; Behrmann I
Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor.
The Journal of biological chemistry 2000;275(52):40742-8.
2000: Huss R; Weissinger E M; Lange C; Gatsios P; Eissner G; Kolb H J; Diebold J; Heinrich P C; Graeve L
In vitro-generated stem cell leukaemia showing altered cell cycle progression with distinct signalling of the tyrosine-phosphorylated rasGAP-associated p62(dok) protein.
The Journal of pathology 2000;192(3):363-72.
2000: Heinrich P C; Bode J G; Graeve L; Haan C; Martens A; Müller-Newen G; Nimmesgern A; Schaper F; Schmitz J; Siewert E
Modulation and termination of interleukin-6 signalling.
European cytokine network 2000;11(3):512-3.
2000: Behrmann I; Hermanns H M; Haan C; Kortylewski M; Radtke S; Greiser J; Heinrich P C
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor.
European cytokine network 2000;11(3):491-2.
2000: Anhuf D; Weissenbach M; Schmitz J; Sobota R; Hermanns H M; Radtke S; Linnemann S; Behrmann I; Heinrich P C; Schaper F
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2535-43.
2000: Huss R; Gatsios P; Graeve L; Lange C; Eissner G; Kolb H J; Thalmeier K; Heinrich P C
Quiescence of CD34-negative haematopoietic stem cells is mediated by downregulation of Cyclin B and no stat activation.
Cytokine 2000;12(8):1195-204.
2000: Terstegen L; Maassen B G; Radtke S; Behrmann I; Schaper F; Heinrich P C; Graeve L; Gatsios P
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.
FEBS letters 2000;478(1-2):100-4.
2000: Blanc C; Vusio P; Schleinkofer K; Boisteau O; Pflanz S; Minvielle S; Grötzinger J; Müller-Newen G; Heinrich P C; Jacques Y; Montero-Julian F A
Monoclonal antibodies against the human interleukin-11 receptor alpha-chain (IL-11Ralpha) and their use in studies of human mononuclear cells.
Journal of immunological methods 2000;241(1-2):43-59.
2000: Siewert E; Bort R; Kluge R; Heinrich P C; Castell J; Jover R
Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent.
Hepatology (Baltimore, Md.) 2000;32(1):49-55.
2000: Haan C; Hermanns H M; Heinrich P C; Behrmann I
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.
The Biochemical journal 2000;349(Pt 1):261-6.
2000: Terstegen L; Gatsios P; Bode J G; Schaper F; Heinrich P C; Graeve L
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.
The Journal of biological chemistry 2000;275(25):18810-7.
2000: Schmitz J; Weissenbach M; Haan S; Heinrich P C; Schaper F
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
The Journal of biological chemistry 2000;275(17):12848-56.
2000: Thiel S; Sommer U; Kortylewski M; Haan C; Behrmann I; Heinrich P C; Graeve L
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis.
FEBS letters 2000;470(1):15-9.
2000: Timmermann A; Pflanz S; Grötzinger J; Küster A; Kurth I; Pitard V; Heinrich P C; Müller-Newen G
Different epitopes are required for gp130 activation by interleukin-6, oncostatin M and leukemia inhibitory factor.
FEBS letters 2000;468(2-3):120-4.
2000: Müller-Newen G; Küster A; Wijdenes J; Schaper F; Heinrich P C
Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.
The Journal of biological chemistry 2000;275(7):4579-86.
2000: Haan S; Kortylewski M; Behrmann I; Müller-Esterl W; Heinrich P C; Schaper F
Cytoplasmic STAT proteins associate prior to activation.
The Biochemical journal 2000;345 Pt 3():417-21.
2000: Schmitz J; Dahmen H; Grimm C; Gendo C; Müller-Newen G; Heinrich P C; Schaper F
The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):848-54.
2000: Kurth I; Horsten U; Pflanz S; Timmermann A; Küster A; Dahmen H; Tacken I; Heinrich P C; Müller-Newen G
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):273-82.
1999: Bode J G; Nimmesgern A; Schmitz J; Schaper F; Schmitt M; Frisch W; Häussinger D; Heinrich P C; Graeve L
LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.
FEBS letters 1999;463(3):365-70.
1999: Hermanns H M; Radtke S; Haan C; Schmitz-Van de Leur H; Tavernier J; Heinrich P C; Behrmann I
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6651-8.
1999: Bode J G; Gatsios P; Ludwig S; Rapp U R; Häussinger D; Heinrich P C; Graeve L
The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity.
The Journal of biological chemistry 1999;274(42):30222-7.
1999: Tacken I; Dahmen H; Boisteau O; Minvielle S; Jacques Y; Grötzinger J; Küster A; Horsten U; Blanc C; Montero-Julian F A; Heinrich P C; Müller-Newen G
Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.
European journal of biochemistry / FEBS 1999;265(2):645-55.
1999: Siewert E; Müller-Esterl W; Starr R; Heinrich P C; Schaper F
Different protein turnover of interleukin-6-type cytokine signalling components.
European journal of biochemistry / FEBS 1999;265(1):251-7.
1999: Kortylewski M; Heinrich P C; Mackiewicz A; Schniertshauer U; Klingmüller U; Nakajima K; Hirano T; Horn F; Behrmann I
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1.
Oncogene 1999;18(25):3742-53.
1999: Pflanz S; Tacken I; Grötzinger J; Jacques Y; Minvielle S; Dahmen H; Heinrich P C; Müller-Newen G
A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130.
FEBS letters 1999;450(1-2):117-22.
1999: Thiel S; Behrmann I; Timmermann A; Dahmen H; Müller-Newen G; Schaper F; Tavernier J; Pitard V; Heinrich P C; Graeve L
Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.
The Biochemical journal 1999;339 ( Pt 1)():15-9.
1999: Kurth I; Horsten U; Pflanz S; Dahmen H; Küster A; Grötzinger J; Heinrich P C; Müller-Newen G
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1480-7.
1999: Kernebeck T; Pflanz S; Müller-Newen G; Kurapkat G; Scheek R M; Dijkstra K; Heinrich P C; Wollmer A; Grzesiek S; Grötzinger J
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region.
Protein science : a publication of the Protein Society 1999;8(1):5-12.
1999: Haan S; Hemmann U; Hassiepen U; Schaper F; Schneider-Mergener J; Wollmer A; Heinrich P C; Grötzinger J
Characterization and binding specificity of the monomeric STAT3-SH2 domain.
The Journal of biological chemistry 1999;274(3):1342-8.
1998: Thiel S; Dahmen H; Martens A; Müller-Newen G; Schaper F; Heinrich P C; Graeve L
Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130.
FEBS letters 1998;441(2):231-4.
1998: Müller-Newen G; Küster A; Hemmann U; Keul R; Horsten U; Martens A; Graeve L; Wijdenes J; Heinrich P C
Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6347-55.
1998: Schaper F; Gendo C; Eck M; Schmitz J; Grimm C; Anhuf D; Kerr I M; Heinrich P C
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
The Biochemical journal 1998;335 ( Pt 3)():557-65.
1998: Jacques Y; Minvielle S; Müller-Newen G; Heinrich P C; Grötzinger J; Montero-Julian F; Brailly H; Wilkin J M; Content J
The interleukin-11/receptor complex: rational design of agonists/antagonists and immunoassays potentially useful in human therapy.
Research in immunology 1998;149(7-8):737-40.
1998: Gatsios P; Terstegen L; Schliess F; Häussinger D; Kerr I M; Heinrich P C; Graeve L
Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock.
The Journal of biological chemistry 1998;273(36):22962-8.
1998: Heinrich P C; Behrmann I; Müller-Newen G; Schaper F; Graeve L
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
The Biochemical journal 1998;334 ( Pt 2)():297-314.
1998: Dahmen H; Horsten U; Küster A; Jacques Y; Minvielle S; Kerr I M; Ciliberto G; Paonessa G; Heinrich P C; Müller-Newen G
Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.
The Biochemical journal 1998;331 ( Pt 3)():695-702.
1998: Thiel S; Behrmann I; Dittrich E; Muys L; Tavernier J; Wijdenes J; Heinrich P C; Graeve L
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway.
The Biochemical journal 1998;330 ( Pt 1)():47-54.
1998: Heinrich P C; Horn F; Graeve L; Dittrich E; Kerr I; Müller-Newen G; Grötzinger J; Wollmer A
Interleukin-6 and related cytokines: effect on the acute phase reaction.
Zeitschrift für Ernährungswissenschaft 1998;37 Suppl 1():43-9.
1997: Roeb E; Purucker E; Breuer B; Nguyen H; Heinrich P C; Rose-John S; Matern S
TIMP expression in toxic and cholestatic liver injury in rat.
Journal of hepatology 1997;27(3):535-44.
1997: Horsten U; Müller-Newen G; Gerhartz C; Wollmer A; Wijdenes J; Heinrich P C; Grötzinger J
Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.
The Journal of biological chemistry 1997;272(38):23748-57.
1997: Sasse J; Hemmann U; Schwartz C; Schniertshauer U; Heesel B; Landgraf C; Schneider-Mergener J; Heinrich P C; Horn F
Mutational analysis of acute-phase response factor/Stat3 activation and dimerization.
Molecular and cellular biology 1997;17(8):4677-86.
1997: Müller-Newen G; Pflanz S; Hassiepen U; Stahl J; Wollmer A; Heinrich P C; Grötzinger J
The signal transducer gp130--bacterial expression, refolding and properties of the carboxy-terminal domain of the cytokine-binding module.
European journal of biochemistry / FEBS 1997;247(1):425-31.
1997: Lebeau B; Montero Julian F A; Wijdenes J; Müller-Newen G; Dahmen H; Chérel M; Heinrich P C; Brailly H; Hallet M M; Godard A; Minvielle S; Jacques Y
Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.
FEBS letters 1997;407(2):141-7.
1997: Schaper F; Siewert E; Gómez-Lechon M J; Gatsios P; Sachs M; Birchmeier W; Heinrich P C; Castell J
Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes.
FEBS letters 1997;405(1):99-103.
1997: Behrmann I; Janzen C; Gerhartz C; Schmitz-Van de Leur H; Hermanns H; Heesel B; Graeve L; Horn F; Tavernier J; Heinrich P C
A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation.
The Journal of biological chemistry 1997;272(8):5269-74.
1996: Graeve L; Korolenko T A; Hemmann U; Weiergräber O; Dittrich E; Heinrich P C
A complex of the soluble interleukin-6 receptor and interleukin-6 is internalized via the signal transducer gp130.
FEBS letters 1996;399(1-2):131-4.
1996: Huppertz C; Schwartz C; Becker W; Horn F; Heinrich P C; Joost H G
Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-gamma on glucose transport in 3T3-L1 cells: lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways.
Diabetologia 1996;39(12):1432-9.
1996: Gatsios P; Haubeck H D; Van de Leur E; Frisch W; Apte S S; Greiling H; Heinrich P C; Graeve L
Oncostatin M differentially regulates tissue inhibitors of metalloproteinases TIMP-1 and TIMP-3 gene expression in human synovial lining cells.
European journal of biochemistry / FEBS 1996;241(1):56-63.
1996: Müller-Newen G; Köhne C; Heinrich P C
Soluble receptors for cytokines and growth factors.
International archives of allergy and immunology 1996;111(2):99-106.
1996: May P; Gerhartz C; Heesel B; Welte T; Doppler W; Graeve L; Horn F; Heinrich P C
Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation.
FEBS letters 1996;394(2):221-6.
1996: Kalai M; Montero-Julian F A; Grötzinger J; Wollmer A; Morelle D; Brochier J; Rose-John S; Heinrich P C; Brailly H; Content J
Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor.
European journal of biochemistry / FEBS 1996;238(3):714-23.
1996: Hemmann U; Gerhartz C; Heesel B; Sasse J; Kurapkat G; Grötzinger J; Wollmer A; Zhong Z; Darnell J E; Graeve L; Heinrich P C; Horn F
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation.
The Journal of biological chemistry 1996;271(22):12999-3007.
1996: Gerhartz C; Heesel B; Sasse J; Hemmann U; Landgraf C; Schneider-Mergener J; Horn F; Heinrich P C; Graeve L
Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation.
The Journal of biological chemistry 1996;271(22):12991-8.
1996: Müller-Newen G; Köhne C; Keul R; Hemmann U; Müller-Esterl W; Wijdenes J; Brakenhoff J P; Hart M H; Heinrich P C
Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing.
European journal of biochemistry / FEBS 1996;236(3):837-42.
1996: Dittrich E; Haft C R; Muys L; Heinrich P C; Graeve L
A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.
The Journal of biological chemistry 1996;271(10):5487-94.
1996: Weiergräber O; Schneider-Mergener J; Grötzinger J; Wollmer A; Küster A; Exner M; Heinrich P C
Use of immobilized synthetic peptides for the identification of contact sites between human interleukin-6 and its receptor.
FEBS letters 1996;379(2):122-6.
1995: Simon R; Thier M; Krüttgen A; Rose-John S; Weiergräber O; Heinrich P C; Schröder J M; Weis J
Human CNTF and related cytokines: effects on DRG neurone survival.
Neuroreport 1995;7(1):153-7.
1995: Bugno M; Graeve L; Gatsios P; Koj A; Heinrich P C; Travis J; Kordula T
Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter.
Nucleic acids research 1995;23(24):5041-7.
1995: Kurschat P; Graeve L; Erren A; Gatsios P; Rose-John S; Roeb E; Tschesche H; Koj A; Heinrich P C
Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat.
European journal of biochemistry / FEBS 1995;234(2):485-91.
1995: Dittrich E; Gerhartz C; Rose-John S; Müllberg J; Stoyan T; Heinrich P C; Graeve L
A region within the cytoplasmic domain of the interleukin-6 signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
Annals of the New York Academy of Sciences 1995;762():410-2.
1995: Mackiewicz A; Wiznerowicz M; Roeb E; Nowak J; Pawlowski T; Baumann H; Heinrich P C; Rose-John S
Interleukin-6-type cytokines and their receptors for gene therapy of melanoma.
Annals of the New York Academy of Sciences 1995;762():361-73; discussion 373-4.
1995: Heinrich P C; Graeve L; Rose-John S; Schneider-Mergener J; Dittrich E; Erren A; Gerhartz C; Hemann U; Lütticken C; Wegenka U
Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction.
Annals of the New York Academy of Sciences 1995;762():222-36; discussion 236-7.
1995: Mackiewicz A; Górny A; Laciak M; Malicki J; Murawa P; Nowak J; Wiznerowicz M; Hawley R G; Heinrich P C; Rose-John S
Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.
Human gene therapy 1995;6(6):805-11.
1995: Thier M; Simon R; Krüttgen A; Rose-John S; Heinrich P C; Schröder J M; Weis J
Site-directed mutagenesis of human CNTF: functional analysis of recombinant variants.
Journal of neuroscience research 1995;40(6):826-35.
1995: Horsten U; Schmitz-Van de Leur H; Müllberg J; Heinrich P C; Rose-John S
The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor.
FEBS letters 1995;360(1):43-6.
1995: Mackiewicz A; Wiznerowicz M; Roeb E; Karczewska A; Nowak J; Heinrich P C; Rose-John S
Soluble interleukin 6 receptor is biologically active in vivo.
Cytokine 1995;7(2):142-9.
1995: Lütticken C; Coffer P; Yuan J; Schwartz C; Caldenhoven E; Schindler C; Kruijer W; Heinrich P C; Horn F
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction.
FEBS letters 1995;360(2):137-43.
1995: Roeb E; Rose-John S; Erren A; Edwards D R; Matern S; Graeve L; Heinrich P C
Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2.
FEBS letters 1995;357(1):33-6.
1994: Horn F; Wegenka U M; Lütticken C; Yuan J; Roeb E; Boers W; Buschmann J; Heinrich P C
Regulation of alpha 2-macroglobulin gene expression by interleukin-6.
Annals of the New York Academy of Sciences 1994;737():308-23.
1994: Dittrich E; Rose-John S; Gerhartz C; Müllberg J; Stoyan T; Yasukawa K; Heinrich P C; Graeve L
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
The Journal of biological chemistry 1994;269(29):19014-20.
1994: Gerhartz C; Dittrich E; Stoyan T; Rose-John S; Yasukawa K; Heinrich P C; Graeve L
Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130.
European journal of biochemistry / FEBS 1994;223(1):265-74.
1994: Rose-John S; Heinrich P C
Soluble receptors for cytokines and growth factors: generation and biological function.
The Biochemical journal 1994;300 ( Pt 2)():281-90.
1994: Schoester M; Heinrich P C; Graeve L
Regulation of interleukin-6 receptor expression by interleukin-6 in human monocytes--a re-examination.
FEBS letters 1994;345(2-3):131-4.
1994: Müllberg J; Oberthür W; Lottspeich F; Mehl E; Dittrich E; Graeve L; Heinrich P C; Rose-John S
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):4958-68.
1994: Wegenka U M; Lütticken C; Buschmann J; Yuan J; Lottspeich F; Müller-Esterl W; Schindler C; Roeb E; Heinrich P C; Horn F
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.
Molecular and cellular biology 1994;14(5):3186-96.
1994: Günther M; Haubeck H D; van de Leur E; Bläser J; Bender S; Gütgemann I; Fischer D C; Tschesche H; Greiling H; Heinrich P C
Transforming growth factor beta 1 regulates tissue inhibitor of metalloproteinases-1 expression in differentiated human articular chondrocytes.
Arthritis and rheumatism 1994;37(3):395-405.
1994: Yuan J; Wegenka U M; Lütticken C; Buschmann J; Decker T; Schindler C; Heinrich P C; Horn F
The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements.
Molecular and cellular biology 1994;14(3):1657-68.
1994: Brakenhoff J P; de Hon F D; Fontaine V; ten Boekel E; Schooltink H; Rose-John S; Heinrich P C; Content J; Aarden L A
Development of a human interleukin-6 receptor antagonist.
The Journal of biological chemistry 1994;269(1):86-93.
1993: Roeb E; Graeve L; Hoffmann R; Decker K; Edwards D R; Heinrich P C
Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures.
Hepatology (Baltimore, Md.) 1993;18(6):1437-42.
1993: Rose-John S; Schooltink H; Schmitz-Van de Leur H; Müllberg J; Heinrich P C; Graeve L
Intracellular retention of interleukin-6 abrogates signaling.
The Journal of biological chemistry 1993;268(29):22084-91.
1993: Müllberg J; Dittrich E; Graeve L; Gerhartz C; Yasukawa K; Taga T; Kishimoto T; Heinrich P C; Rose-John S
Differential shedding of the two subunits of the interleukin-6 receptor.
FEBS letters 1993;332(1-2):174-8.
1993: Stoyan T; Michaelis U; Schooltink H; Van Dam M; Rudolph R; Heinrich P C; Rose-John S
Recombinant soluble human interleukin-6 receptor. Expression in Escherichia coli, renaturation and purification.
European journal of biochemistry / FEBS 1993;216(1):239-45.
1993: van Dam M; Müllberg J; Schooltink H; Stoyan T; Brakenhoff J P; Graeve L; Heinrich P C; Rose-John S
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding.
The Journal of biological chemistry 1993;268(20):15285-90.
1993: Kordula T; Dubin A; Schooltink H; Koj A; Heinrich P C; Rose-John S
Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes.
The Biochemical journal 1993;293 ( Pt 1)():187-93.
1993: Pietzko D; Zohlnhöfer D; Graeve L; Fleischer D; Stoyan T; Schooltink H; Rose-John S; Heinrich P C
The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone.
The Journal of biological chemistry 1993;268(6):4250-8.
1993: Müllberg J; Schooltink H; Stoyan T; Günther M; Graeve L; Buse G; Mackiewicz A; Heinrich P C; Rose-John S
The soluble interleukin-6 receptor is generated by shedding.
European journal of immunology 1993;23(2):473-80.
1993: Wegenka U M; Buschmann J; Lütticken C; Heinrich P C; Horn F
Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.
Molecular and cellular biology 1993;13(1):276-88.
1992: Müllberg J; Schooltink H; Stoyan T; Heinrich P C; Rose-John S
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.
Biochemical and biophysical research communications 1992;189(2):794-800.
1992: Schooltink H; Stoyan T; Roeb E; Heinrich P C; Rose-John S
Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes.
FEBS letters 1992;314(3):280-4.
1992: Kordula T; Güttgemann I; Rose-John S; Roeb E; Osthues A; Tschesche H; Koj A; Heinrich P C; Graeve L
Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1.
FEBS letters 1992;313(2):143-7.
1992: Mackiewicz A; Schooltink H; Heinrich P C; Rose-John S
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2021-7.
1992: Krause E; Wegenka U; Möller C; Horn F; Heinrich P C
Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin.
Biological chemistry Hoppe-Seyler 1992;373(7):509-15.
1992: Mackiewicz A; Rose-John S; Schooltink H; Laciak M; Górny A; Heinrich P C
Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of alpha 1-protease inhibitor secreted by HepG2 cells.
FEBS letters 1992;306(2-3):257-61.
1992: Zohlnhöfer D; Graeve L; Rose-John S; Schooltink H; Dittrich E; Heinrich P C
The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand.
FEBS letters 1992;306(2-3):219-22.
1992: Klosterhalfen B; Hörstmann-Jungemann K; Vogel P; Flohé S; Offner F; Kirkpatrick C J; Heinrich P C
Time course of various inflammatory mediators during recurrent endotoxemia.
Biochemical pharmacology 1992;43(10):2103-9.
1992: Schooltink H; Schmitz-Van de Leur H; Heinrich P C; Rose-John S
Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells.
FEBS letters 1992;297(3):263-5.
1992: Kordula T; Rose-John S; Heinrich P C; Koj A
Interferon-gamma regulates alpha 2-macroglobulin and alpha 1-antichymotrypsin expression on the pretranslational level in HepG2 cells.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1992;30(4):147-9.
1991: Schooltink H; Stoyan T; Lenz D; Schmitz H; Hirano T; Kishimoto T; Heinrich P C; Rose-John S
Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.
The Biochemical journal 1991;277 ( Pt 3)():659-64.
1991: Flohé S; Heinrich P C; Schneider J; Wendel A; Flohé L
Time course of IL-6 and TNF alpha release during endotoxin-induced endotoxin tolerance in rats.
Biochemical pharmacology 1991;41(11):1607-14.
1991: Lütticken C; Krüttgen A; Möller C; Heinrich P C; Rose-John S
Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.
FEBS letters 1991;282(2):265-7.
1991: Rose-John S; Hipp E; Lenz D; Legrés L G; Korr H; Hirano T; Kishimoto T; Heinrich P C
Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA.
The Journal of biological chemistry 1991;266(6):3841-6.
1990: Gross V; Ludolph D; Vom Berg D; Kreisel W; Andus T; Katz N; Giffhorn-Katz S; Heinrich P C; Gerok W
Hepatocyte specific long lasting inhibition of protein N-glycosylation by D-galactosamine.
Biochimica et biophysica acta 1990;1036(2):143-50.
1990: Castell J V; Gómez-Lechón M J; David M; Fabra R; Trullenque R; Heinrich P C
Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6.
Hepatology (Baltimore, Md.) 1990;12(5):1179-86.
1990: Krüttgen A; Rose-John S; Dufhues G; Bender S; Lütticken C; Freyer P; Heinrich P C
The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity.
FEBS letters 1990;273(1-2):95-8.
1990: Rose-John S; Schooltink H; Lenz D; Hipp E; Dufhues G; Schmitz H; Schiel X; Hirano T; Kishimoto T; Heinrich P C
Studies on the structure and regulation of the human hepatic interleukin-6 receptor.
European journal of biochemistry / FEBS 1990;190(1):79-83.
1990: Schiel X; Rose-John S; Dufhues G; Schooltink H; Gross V; Heinrich P C
Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: comparison with human monocytes, fibroblasts and endothelial cells.
European journal of immunology 1990;20(4):883-7.
1990: Bender S; Haubeck H D; Van de Leur E; Dufhues G; Schiel X; Lauwerijns J; Greiling H; Heinrich P C
Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes.
FEBS letters 1990;263(2):321-4.
1990: Castell J; Klapproth J; Gross V; Walter E; Andus T; Snyers L; Content J; Heinrich P C
Fate of interleukin-6 in the rat. Involvement of skin in its catabolism.
European journal of biochemistry / FEBS 1990;189(1):113-8.
1990: Krüttgen A; Rose-John S; Möller C; Wroblowski B; Wollmer A; Müllberg J; Hirano T; Kishimoto T; Heinrich P C
Structure-function analysis of human interleukin-6. Evidence for the involvement of the carboxy-terminus in function.
FEBS letters 1990;262(2):323-6.
1990: Heinrich P C; Castell J V; Andus T
Interleukin-6 and the acute phase response.
The Biochemical journal 1990;265(3):621-36.
1989: Andus T; Heinrich P C; Castell J C; Gerok W
[Interleukin-6: a key hormone of the acute phase reaction]
Deutsche medizinische Wochenschrift (1946) 1989;114(44):1710-6.
1989: Ludolph D; Gross V; Katz N R; Giffhorn-Katz S; Kreisel W; Heinrich P C; Gerok W
Effect of the alpha-glucosidase inhibitor N-hydroxyethyl-1-deoxynojirimycin (Bay m 1099) on the biosynthesis of liver secretory glycoproteins.
Biochemical pharmacology 1989;38(15):2479-86.
1989: Klapproth J; Castell J; Geiger T; Andus T; Heinrich P C
Fate and biological action of human recombinant interleukin 1 beta in the rat in vivo.
European journal of immunology 1989;19(8):1485-90.
1989: Gross V; Andus T; Castell J; Vom Berg D; Heinrich P C; Gerok W
O- and N-glycosylation lead to different molecular mass forms of human monocyte interleukin-6.
FEBS letters 1989;247(2):323-6.
1989: Gross V; Steube K; Tran-Thi T A; Gerok W; Heinrich P C
Role of N-glycosylation for the plasma clearance of rat liver secretory glycoproteins.
Biochemical Society transactions 1989;17(1):21-3.
1989: Kunz D; Zimmermann R; Heisig M; Heinrich P C
Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha 2-macroglobulin gene.
Nucleic acids research 1989;17(3):1121-38.
1989: Castell J V; Gómez-Lechón M J; David M; Andus T; Geiger T; Trullenque R; Fabra R; Heinrich P C
Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes.
FEBS letters 1989;242(2):237-9.
1989: Gross V; Heinrich P C; Berg D V; Steube K; Tran-Thi T A; Decker K; Gerok W
Circulatory life time and organ distribution of differently glycosylated forms (unglycosylated, high-mannose type, hybrid type, complex type) of rat alpha-1-acid glycoprotein.
Progress in clinical and biological research 1989;300():231-4.
1989: Castell J V; Andus T; Kunz D; Heinrich P C
Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat.
Annals of the New York Academy of Sciences 1989;557():87-99; discussion 100-1.
1988: Andus T; Geiger T; Klapproth J; Kunz D; Heisig M; Castell J; Heinrich P C
Regulation of alpha 2-macroglobulin gene expression by interleukin-6 (BSF-2/HSF).
The Tokai journal of experimental and clinical medicine 1988;13(6):265-76.
1988: Castell J V; Geiger T; Gross V; Andus T; Walter E; Hirano T; Kishimoto T; Heinrich P C
Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat.
European journal of biochemistry / FEBS 1988;177(2):357-61.
1988: Geiger T; Andus T; Bauer J; Northoff H; Ganter U; Hirano T; Kishimoto T; Heinrich P C
Cell-free-synthesized interleukin-6 (BSF-2/IFN-beta 2) exhibits hepatocyte-stimulating activity.
European journal of biochemistry / FEBS 1988;175(1):181-6.
1988: Geiger T; Andus T; Klapproth J; Northoff H; Heinrich P C
Induction of alpha 1-acid glycoprotein by recombinant human interleukin-1 in rat hepatoma cells.
The Journal of biological chemistry 1988;263(15):7141-6.
1988: Castell J V; Gómez-Lechón M J; David M; Hirano T; Kishimoto T; Heinrich P C
Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes.
FEBS letters 1988;232(2):347-50.
1988: Andus T; Geiger T; Hirano T; Kishimoto T; Heinrich P C
Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins.
European journal of immunology 1988;18(5):739-46.
1988: Geiger T; Andus T; Klapproth J; Hirano T; Kishimoto T; Heinrich P C
Induction of rat acute-phase proteins by interleukin 6 in vivo.
European journal of immunology 1988;18(5):717-21.
1988: Gross V; Heinrich P C; vom Berg D; Steube K; Andus T; Tran-Thi T A; Decker K; Gerok W
Involvement of various organs in the initial plasma clearance of differently glycosylated rat liver secretory proteins.
European journal of biochemistry / FEBS 1988;173(3):653-9.
1988: Andus T; Geiger T; Hirano T; Kishimoto T; Tran-Thi T A; Decker K; Heinrich P C
Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures.
European journal of biochemistry / FEBS 1988;173(2):287-93.
1988: Geiger T; Andus T; Kunz D; Heisig M; Bauer J; Northoff N; Gauthier F; Tran-Thi T A; Decker K; Heinrich P C
Regulation of proteinase activity by high molecular weight inhibitors: biosynthesis of rat alpha-macroglobulins.
Advances in experimental medicine and biology 1988;240():183-9.
1987: Andus T; Ramadori G; Heinrich P C; Knittel T; Meyer zum Büschenfelde K H
Cultured Ito cells of rat liver express the alpha 2-macroglobulin gene.
European journal of biochemistry / FEBS 1987;168(3):641-6.
1987: Andus T; Geiger T; Hirano T; Northoff H; Ganter U; Bauer J; Kishimoto T; Heinrich P C
Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells.
FEBS letters 1987;221(1):18-22.
1987: Geiger T; Lamri Y; Tran-Thi T A; Gauthier F; Feldmann G; Decker K; Heinrich P C
Biosynthesis and regulation of rat alpha 1-inhibitor3, a negative acute-phase reactant of the macroglobulin family.
The Biochemical journal 1987;245(2):493-500.
1987: Geiger T; Tran-Thi T A; Decker K; Heinrich P C
Biosynthesis of rat alpha 1-macroglobulin. Identification of an intracellular precursor.
The Journal of biological chemistry 1987;262(11):4973-7.
1986: Kodelja V; Heisig M; Northemann W; Heinrich P C; Zimmermann W
Alpha 2-macroglobulin gene expression during rat development studied by in situ hybridization.
The EMBO journal 1986;5(12):3151-6.
1986: Steube K; Gross V; Häussinger D; Tran-Thi T A; Decker K; Gerok W; Heinrich P C
Clearance of acute-phase plasma proteins with no, high-mannose-, hybrid-, or complex type oligosaccharide side chains by the isolated perfused rat liver.
Biochemical and biophysical research communications 1986;141(3):949-55.
1985: Gross V; Steube K; Tran-Thi T A; McDowell W; Schwarz R T; Decker K; Gerok W; Heinrich P C
Secretion of high-mannose-type alpha 1-proteinase inhibitor and alpha 1-acid glycoprotein by primary cultures of rat hepatocytes in the presence of the mannosidase I inhibitor 1-deoxymannojirimycin.
European journal of biochemistry / FEBS 1985;150(1):41-6.
1985: Northemann W; Heisig M; Kunz D; Heinrich P C
Molecular cloning of cDNA sequences for rat alpha 2-macroglobulin and measurement of its transcription during experimental inflammation.
The Journal of biological chemistry 1985;260(10):6200-5.
1985: Northemann W; Heisig M; Kunz D; Bauer J; Birmelin M; Tran-Thi T A; Decker K; Heinrich P C
Biosynthesis of rat alpha 2-macroglobulin.
Biochemical Society transactions 1985;13(2):285-8.
1985: Weber W; Steube K; Gross V; Tran-Thi T A; Decker K; Gerok W; Heinrich P C
Unglycosylated rat alpha 1-proteinase inhibitor has a six-fold shorter plasma half-life than the mature glycoprotein.
Biochemical and biophysical research communications 1985;126(1):630-5.
1984: Bauer J; Birmelin M; Northoff G H; Northemann W; Tran-Thi T A; Ueberberg H; Decker K; Heinrich P C
Induction of rat alpha 2-macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell-derived factor.
FEBS letters 1984;177(1):89-94.
1982: Gross V; Geiger T; Tran-Thi T A; Gauthier F; Heinrich P C
Biosynthesis and secretion of alpha 1-antitrypsin in primary cultures of rat hepatocytes. Characterization of differently glycosylated intracellular and extracellular forms.
European journal of biochemistry / FEBS 1982;129(2):317-23.

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