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Dirk Heinz

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X Ray Crystallography

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TOP 3
Jürgen Moser; Johannes Rebelein; Markus W Ribbe; Wolf-Dieter Schubert; Dirk W Heinz; Joern Krausze; Christiane Lange; Dieter Jahn
Structure of ADP-aluminium fluoride-stabilized protochlorophyllide oxidoreductase complex.
Nick Quade; Christiane Ritter; Dirk W Heinz; Katharina Herbst; Ann Kathrin Heroven; Chriselle Mendonca; Petra Dersch
Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia.
Jens C de Groot; Jan Faix; Dirk W Heinz; John M Leong; Cammie F Lesser; Claudia Quedenau; Joachim Reichelt; Kai Schlüter; Christine Standfuss-Gabisch; Konrad Büssow; Yvonne Carius; Didier Vingadassalom; Stefanie M Weiss; Theresia E B Stradal
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.

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All Publications

2013: Jürgen Moser; Johannes Rebelein; Markus W Ribbe; Wolf-Dieter Schubert; Dirk W Heinz; Joern Krausze; Christiane Lange; Dieter Jahn
Structure of ADP-aluminium fluoride-stabilized protochlorophyllide oxidoreductase complex.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2094-8.
2012: Nick Quade; Christiane Ritter; Dirk W Heinz; Katharina Herbst; Ann Kathrin Heroven; Chriselle Mendonca; Petra Dersch
Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia.
The Journal of biological chemistry 2012;287(43):35796-803.
2011: Jens C de Groot; Jan Faix; Dirk W Heinz; John M Leong; Cammie F Lesser; Claudia Quedenau; Joachim Reichelt; Kai Schlüter; Christine Standfuss-Gabisch; Konrad Büssow; Yvonne Carius; Didier Vingadassalom; Stefanie M Weiss; Theresia E B Stradal
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.
Structure (London, England : 1993) 2011;19(9):1294-306.
2011: Sonja Storbeck; Sayantan Saha; Dirk W Heinz; Björn U Klink; Joern Krausze; Gunhild Layer
Crystal structure of the heme d1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases.
The Journal of biological chemistry 2011;286(30):26754-67.
2011: Christian P Strube; Arne Homann; Martin Gamer; Dieter Jahn; Jürgen Seibel; Dirk W Heinz
Polysaccharide synthesis of the levansucrase SacB from Bacillus megaterium is controlled by distinct surface motifs.
The Journal of biological chemistry 2011;286(20):17593-600.
2011: Nick Quade; Marieke Dieckmann; Matthias Haffke; Ann Kathrin Heroven; Petra Dersch; Dirk W Heinz
Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 2):81-90.
2010: Matthias Haffke; Anja Menzel; Yvonne Carius; Dieter Jahn; Dirk W Heinz
Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 9):979-87.
2010: Markus J Bröcker; Sebastian Schomburg; Dirk W Heinz; Dieter Jahn; Wolf-Dieter Schubert; Jürgen Moser
Crystal structure of the nitrogenase-like dark operative protochlorophyllide oxidoreductase catalytic complex (ChlN/ChlB)2.
The Journal of biological chemistry 2010;285(35):27336-45.
2010: Gunhild Layer; Joachim Reichelt; Dieter Jahn; Dirk W Heinz
Structure and function of enzymes in heme biosynthesis.
Protein science : a publication of the Protein Society 2010;19(6):1137-61.
2010: Davide M Ferraris; Ermanno Gherardi; Ying Di; Dirk W Heinz; Hartmut H Niemann
Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.
Journal of molecular biology 2010;395(3):522-32.
2010: Katrin Rand; Claudia Noll; Hans Martin Schiebel; Dorit Kemken; Thomas Dülcks; Markus Kalesse; Dirk W Heinz; Gunhild Layer
The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX.
Biological chemistry 2010;391(1):55-63.
2010: Ilka U Heinemann; Claudia Schulz; Wolf-Dieter Schubert; Dirk W Heinz; Yang-G Wang; Yuichi Kobayashi; Yuuki Awa; Masaaki Wachi; Dieter Jahn; Martina Jahn
Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin.
Antimicrobial agents and chemotherapy 2010;54(1):267-72.
2009: Maike Bublitz; Lilia Polle; Christin Holland; Dirk W Heinz; Manfred Nimtz; Wolf-Dieter Schubert
Structural basis for autoinhibition and activation of Auto, a virulence-associated peptidoglycan hydrolase of Listeria monocytogenes.
Molecular microbiology 2009;71(6):1509-22.
2009: Ulrich Wiesand; Isabel Sorg; Marlise Amstutz; Stefanie Wagner; Joop van den Heuvel; Thorsten Lührs; Guy R Cornelis; Dirk W Heinz
Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica.
Journal of molecular biology 2009;385(3):854-66.
2009: Gregor Hagelueken; Simone C Albrecht; Heinrich Steinmetz; Rolf Jansen; Dirk W Heinz; Markus Kalesse; Wolf-Dieter Schubert
The absolute configuration of rhizopodin and its inhibition of actin polymerization by dimerization.
Angewandte Chemie (International ed. in English) 2009;48(3):595-8.
2008: Maike Bublitz; Christin Holland; Christophe Sabet; Joachim Reichelt; Pascale Cossart; Dirk W Heinz; Helene bierne; Wolf-Dieter Schubert
Crystal structure and standardized geometric analysis of InlJ, a listerial virulence factor and leucine-rich repeat protein with a novel cysteine ladder.
Journal of molecular biology 2008;378(1):87-96.
2008: Markus J Bröcker; Simone Virus; Stefanie Ganskow; Peter Heathcote; Dirk W Heinz; Wolf-Dieter Schubert; Dieter Jahn; Jürgen Moser
ATP-driven reduction by dark-operative protochlorophyllide oxidoreductase from Chlorobium tepidum mechanistically resembles nitrogenase catalysis.
The Journal of biological chemistry 2008;283(16):10559-67.
2008: Hartmut H Niemann; Maxim V Petoukhov; Michael Härtlein; Martine Moulin; Ermanno Gherardi; Peter Timmins; Dirk W Heinz; Dmitri I Svergun
X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB.
Journal of molecular biology 2008;377(2):489-500.
2008: Carina R Büttner; Isabel Sorg; Guy R Cornelis; Dirk W Heinz; Hartmut H Niemann
Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycD.
Journal of molecular biology 2008;375(4):997-1012.
2007: Corinna Lüer; Stefan Schauer; Simone Virus; Wolf-Dieter Schubert; Dirk W Heinz; Jürgen Moser; Dieter Jahn
Glutamate recognition and hydride transfer by Escherichia coli glutamyl-tRNA reductase.
The FEBS journal 2007;274(17):4609-14.
2007: Thomas Wollert; Dirk W Heinz; Wolf-Dieter Schubert
Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13960-5.
2007: Hartmut H Niemann; Volker Jäger; P Jonathan G Butler; Joop van den Heuvel; Sabine Schmidt; Davide Ferraris; Ermanno Gherardi; Dirk W Heinz
Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.
Cell 2007;130(2):235-46.
2007: Gregor Hagelueken; Lutz Wiehlmann; Thorsten M Adams; Harald Kolmar; Dirk W Heinz; Burkhard Tümmler; Wolf-Dieter Schubert
Crystal structure of the electron transfer complex rubredoxin rubredoxin reductase of Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12276-81.
2007: Thomas Wollert; Bastian Pasche; Maike Rochon; Stefanie Deppenmeier; Joop van den Heuvel; Achim D Gruber; Dirk W Heinz; Andreas Lengeling; Wolf-Dieter Schubert
Extending the host range of Listeria monocytogenes by rational protein design.
Cell 2007;129(5):891-902.
2006: Jörg O Schulze; Ava Masoumi; Daniel Nickel; Martina Jahn; Dieter Jahn; Wolf-Dieter Schubert; Dirk W Heinz
Crystal structure of a non-discriminating glutamyl-tRNA synthetase.
Journal of molecular biology 2006;361(5):888-97.
2006: Frederic Frère; Merle Nentwich; Sabine Gacond; Dirk W Heinz; Reinhard Neier; Nicole Frankenberg-Dinkel
Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors.
Biochemistry 2006;45(27):8243-53.
2006: Susanne Frese; Wolf-Dieter Schubert; Antje C Findeis; Tobias Marquardt; Yvette S Roske; Theresia E B Stradal; Dirk W Heinz
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.
The Journal of biological chemistry 2006;281(26):18236-45.
2006: Gunhild Layer; Antonio J Pierik; Matthias Trost; Stephen E J Rigby; Helen K Leech; Katrin Grage; Daniela Breckau; Isabel Astner; Lothar Jänsch; Peter Heathcote; Martin J Warren; Dirk W Heinz; Dieter Jahn
The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN.
The Journal of biological chemistry 2006;281(23):15727-34.
2006: Jörg O Schulze; Wolf-Dieter Schubert; Jürgen Moser; Dieter Jahn; Dirk W Heinz
Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis.
Journal of molecular biology 2006;358(5):1212-20.
2006: Gregor Hagelueken; Thorsten M Adams; Lutz Wiehlmann; Ute Widow; Harald Kolmar; Burkhard Tümmler; Dirk W Heinz; Wolf-Dieter Schubert
The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7631-6.
2006: Hartmut H Niemann; Hans-Ulrich Schmoldt; Alexander Wentzel; Harald Kolmar; Dirk W Heinz
Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI.
Journal of molecular biology 2006;356(1):1-8.
2005: Gunhild Layer; Eric Kervio; Gaby Morlock; Dirk W Heinz; Dieter Jahn; Janos Retey; Wolf-Dieter Schubert
Structural and functional comparison of HemN to other radical SAM enzymes.
Biological chemistry 2005;386(10):971-80.
2005: Isabel Astner; Jörg O Schulze; Joop van den Heuvel; Dieter Jahn; Wolf-Dieter Schubert; Dirk W Heinz
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.
The EMBO journal 2005;24(18):3166-77.
2005: Carina R Büttner; Guy R Cornelis; Dirk W Heinz; Hartmut H Niemann
Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT.
Protein science : a publication of the Protein Society 2005;14(8):1993-2002.
2005: Corinna Lüer; Stefan Schauer; Kalle Möbius; Jörg O Schulze; Wolf-Dieter Schubert; Dirk W Heinz; Dieter Jahn; Jürgen Moser
Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.
The Journal of biological chemistry 2005;280(19):18568-72.
2005: Marina Eiting; Gregor Hagelüken; Wolf-Dieter Schubert; Dirk W Heinz
The mutation G145S in PrfA, a key virulence regulator of Listeria monocytogenes, increases DNA-binding affinity by stabilizing the HTH motif.
Molecular microbiology 2005;56(2):433-46.
2005: Joachim Reichelt; Guido Dieterich; Marsel Kvesic; Dietmar Schomburg; Dirk W Heinz
BRAGI: linking and visualization of database information in a 3D viewer and modeling tool.
Bioinformatics (Oxford, England) 2005;21(7):1291-3.
2005: Dirk W Heinz; Wolf-Dieter Schubert; Gerhard Höfle
Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.
Angewandte Chemie (International ed. in English) 2005;44(9):1298-301.
2005: Frederic Frère; Heike Reents; Wolf-Dieter Schubert; Dirk W Heinz; Dieter Jahn
Tracking the evolution of porphobilinogen synthase metal dependence in vitro.
Journal of molecular biology 2005;345(5):1059-70.
2004: Stefanie Ehinger; Wolf-Dieter Schubert; Simone Bergmann; Sven Hammerschmidt; Dirk W Heinz
Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites.
Journal of molecular biology 2004;343(4):997-1005.
2004: Gunhild Layer; Dirk W Heinz; Dieter Jahn; Wolf-Dieter Schubert
Structure and function of radical SAM enzymes.
Current opinion in chemical biology 2004;8(5):468-76.
2004: Alexander Freiberg; Matthias Machner; Wolfgang Pfeil; Wolf-Dieter Schubert; Dirk W Heinz; Robert Seckler
Folding and stability of the leucine-rich repeat domain of internalin B from Listeri monocytogenes.
Journal of molecular biology 2004;337(2):453-61.
2004: Hartmut H Niemann; Wolf-Dieter Schubert; Dirk W Heinz
Adhesins and invasins of pathogenic bacteria: a structural view.
Microbes and infection / Institut Pasteur 2004;6(1):101-12.
2003: Wolf-Dieter Schubert; Dirk W Heinz
Structural aspects of adhesion to and invasion of host cells by the human pathogen Listeria monocytogenes.
Chembiochem : a European journal of chemical biology 2003;4(12):1285-91.
2003: Gunhild Layer; Jürgen Moser; Dirk W Heinz; Dieter Jahn; Wolf-Dieter Schubert
Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes.
The EMBO journal 2003;22(23):6214-24.
2003: Matthias Machner; Susanne Frese; Wolf-Dieter Schubert; Veronique Orian-Rousseau; Ermanno Gherardi; Jürgen Wehland; Hartmut H Niemann; Dirk W Heinz
Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes.
Molecular microbiology 2003;48(6):1525-36.
2002: Wolf-Dieter Schubert; Claus Urbanke; Thilo Ziehm; Viola Beier; Matthias Machner; Eugen Domann; Jürgen Wehland; Trinad Chakraborty; Dirk W Heinz
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.
Cell 2002;111(6):825-36.
2002: Stefan Schauer; Shalini Chaturvedi; Lennart Randau; Jürgen Moser; Makoto Kitabatake; Stefan Lorenz; Elizabeth Verkamp; Wolf-Dieter Schubert; Toru Nakayashiki; Masatoshi Murai; Kristen Wall; Hans-Ulrich Thomann; Dirk W Heinz; Hachiro Inokuchi; Dieter Söll; Dieter Jahn
Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate.
The Journal of biological chemistry 2002;277(50):48657-63.
2002: Jürgen Moser; Wolf-Dieter Schubert; Dirk W Heinz; Dieter Jahn
Structure and function of glutamyl-tRNA reductase involved in 5-aminolaevulinic acid formation.
Biochemical Society transactions 2002;30(4):579-84.
2002: Frederic Frère; Wolf-Dieter Schubert; Frédéric Stauffer; Nicole Frankenberg; Reinhard Neier; Dieter Jahn; Dirk W Heinz
Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism.
Journal of molecular biology 2002;320(2):237-47.
2001: Jürgen Moser; Wolf-Dieter Schubert; V Beier; I Bringemeier; Dieter Jahn; Dirk W Heinz
V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA-dependent tetrapyrrole biosynthesis.
The EMBO journal 2001;20(23):6583-90.
2001: Matthias Machner; Claus Urbanke; M Barzik; Sonja Otten; Antonio S Sechi; Jürgen Wehland; Dirk W Heinz
ActA from Listeria monocytogenes can interact with up to four Ena/VASP homology 1 domains simultaneously.
The Journal of biological chemistry 2001;276(43):40096-103.
2001: Wolf-Dieter Schubert; G Göbel; M Diepholz; Ayub Darji; D Kloer; Torsten Hain; Trinad Chakraborty; Jürgen Wehland; Eugen Domann; Dirk W Heinz
Internalins from the human pathogen Listeria monocytogenes combine three distinct folds into a contiguous internalin domain.
Journal of molecular biology 2001;312(4):783-94.
2001: M Barzik; Uwe D Carl; Wolf-Dieter Schubert; R Frank; Jürgen Wehland; Dirk W Heinz
The N-terminal domain of Homer/Vesl is a new class II EVH1 domain.
Journal of molecular biology 2001;309(1):155-69.
2000: M Barzik; Wolf-Dieter Schubert; Uwe D Carl; Jürgen Wehland; Dirk W Heinz
Crystallization and preliminary X-ray analysis of the EVH1 domain of Vesl-2b.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):930-2.
1999: Nicole Frankenberg; Dirk W Heinz; Dieter Jahn
Production, purification, and characterization of a Mg2+-responsive porphobilinogen synthase from Pseudomonas aeruginosa.
Biochemistry 1999;38(42):13968-75.
1999: Nicole Frankenberg; Peter T Erskine; Jonathan B Cooper; Peter M Shoolingin-Jordan; Dieter Jahn; Dirk W Heinz
High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase.
Journal of molecular biology 1999;289(3):591-602.
1998: Dirk W Heinz; L O Essen; R L Williams
Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C.
Journal of molecular biology 1998;275(4):635-50.
1997: Claudia Gässler; M Ryan; T Liu; O H Griffith; Dirk W Heinz
Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis.
Biochemistry 1997;36(42):12802-13.
1997: Jürgen Moser; Birgit Gerstel; JE Meyer; Trinad Chakraborty; Jürgen Wehland; Dirk W Heinz
Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes.
Journal of molecular biology 1997;273(1):269-82.
1996: Dirk W Heinz; M Ryan; M P Smith; L H Weaver; J F Keana; O H Griffith
Crystal structure of phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with glucosaminyl(alpha 1-->6)-D-myo-inositol, an essential fragment of GPI anchors.
Biochemistry 1996;35(29):9496-504.
1995: Dirk W Heinz; M Ryan; T L Bullock; O H Griffith
Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol.
The EMBO journal 1995;14(16):3855-63.