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Marc Achen

Research Profile

Chemicals & Drugs

Phenomena

Lymphangiogenesis

Living Beings

Mouse

Anatomy

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Physiology

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Nicole C Harris; Tara Karnezis; Edouard C Nice; Karri Paavonen; Sophie Paquet-Fifield; Julie Rothacker; Sally Roufail; Teruhiko Sato; Steven A Stacker; You-Fang Zhang; Natalia Davydova; Marc G Achen
The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology.
Ramin Shayan; G Ian Taylor; Marc G Achen; Mark W Ashton; Carol Caesar; Rachael Inder; Tara Karnezis; G Bruce Mann; Karri Paavonen; Steven A Stacker
Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.
Kelly L Betterman; Lisa M Butler; Marc G Achen; Marie-Liesse Asselin-Labat; Sophie Paquet-Fifield; Steven A Stacker; Jane E Visvader; Natasha L Harvey
Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.

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All Publications

2013: Nicole C Harris; Tara Karnezis; Edouard C Nice; Karri Paavonen; Sophie Paquet-Fifield; Julie Rothacker; Sally Roufail; Teruhiko Sato; Steven A Stacker; You-Fang Zhang; Natalia Davydova; Marc G Achen
The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology.
The Journal of biological chemistry 2013;288(12):8176-86.
2013: Ramin Shayan; G Ian Taylor; Marc G Achen; Mark W Ashton; Carol Caesar; Rachael Inder; Tara Karnezis; G Bruce Mann; Karri Paavonen; Steven A Stacker
Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.
Clinical & experimental metastasis 2013;30(3):345-56.
2012: Kelly L Betterman; Lisa M Butler; Marc G Achen; Marie-Liesse Asselin-Labat; Sophie Paquet-Fifield; Steven A Stacker; Jane E Visvader; Natasha L Harvey
Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
The American journal of pathology 2012;181(6):2225-38.
2012: Marc G Achen; Steven A Stacker
Vascular endothelial growth factor-D: signaling mechanisms, biology, and clinical relevance.
Growth factors (Chur, Switzerland) 2012;30(5):283-96.
2012: Tara Karnezis; Ramin Shayan; Marc G Achen; Stephen Fox; Steven A Stacker
The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway.
Oncotarget 2012;3(8):893-906.
2012: Natalia Davydova; George O Lovrecz; Sally Roufail; Steven A Stacker; Victor A Streltsov; Timothy E Adams; Marc G Achen
Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.
Protein expression and purification 2012;82(1):232-9.
2012: Tara Karnezis; Sally Roufail; Thusitha W T Rupasinghe; Ramin Shayan; Erica K Sloan; Dedreia L Tull; Steven P Williams; You Fang Zhang; Marc G Achen; Kathryn Ardipradja; Megan E Baldwin; Carol Caesar; Ming G Chai; Rae H Farnsworth; Stephen B Fox; Nicole C Harris; Steven A Stacker
VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium.
Cancer cell 2012;21(2):181-95.
2011: Rae H Farnsworth; Tara Karnezis; Masataka Matsumoto; Cameron Nowell; Ramin Shayan; Marc G Achen; Steven A Stacker
A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth.
Cancer research 2011;71(20):6547-57.
2011: Natalia Davydova; Sally Roufail; Victor A Streltsov; Steven A Stacker; Marc G Achen
The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor binding.
Journal of molecular biology 2011;407(4):581-93.
2010: Steven P Williams; Tara Karnezis; Marc G Achen; Steven A Stacker
Targeting lymphatic vessel functions through tyrosine kinases.
Journal of angiogenesis research 2010;2():13.
2010: Jane E Girling; Jacqueline F Donoghue; Fiona L Lederman; Leonie M Cann; Marc G Achen; Steven A Stacker; Peter Aw Rogers
Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer.
Reproductive biology and endocrinology : RB&E 2010;8():84.
2008: Mathias François; Andrea Caprini; Brett Hosking; Fabrizio Orsenigo; Dagmar Wilhelm; Catherine Browne; Karri Paavonen; Tara Karnezis; Ramin Shayan; Meredith Downes; Tara Davidson; Desmond Tutt; Kathryn S E Cheah; Steven A Stacker; George E O Muscat; Marc G Achen; Elisabetta Dejana; Peter Koopman
Sox18 induces development of the lymphatic vasculature in mice.
Nature 2008;456(7222):643-7.
2008: Marc G Achen; Steven A Stacker
Targeting tumor stroma.
Current cancer drug targets 2008;8(6):446.
2008: Paula Haiko; Taija Makinen; Salla Keskitalo; Jussi Taipale; Marika J Karkkainen; Megan E Baldwin; Steven A Stacker; Marc G Achen; Kari Alitalo
Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.
Molecular and cellular biology 2008;28(15):4843-50.
2008: Marc G Achen; Steven A Stacker
Molecular control of lymphatic metastasis.
Annals of the New York Academy of Sciences 2008;1131():225-34.
2007: Ramin Shayan; Tara Karnezis; Evelyn Tsantikos; Steven P Williams; Andrew S Runting; Mark W Ashton; Marc G Achen; Margaret L Hibbs; Steven A Stacker
A system for quantifying the patterning of the lymphatic vasculature.
Growth factors (Chur, Switzerland) 2007;25(6):417-25.
2007: Lucie Kopfstein; Tanja Veikkola; Valentin Djonov; Vanessa Baeriswyl; Tibor Schomber; Karin Strittmatter; Steven A Stacker; Marc G Achen; Kari Alitalo; Gerhard Christofori
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.
The American journal of pathology 2007;170(4):1348-61.
2007: Bradley K McColl; Karri Paavonen; Tara Karnezis; Nicole C Harris; Natalia Davydova; Julie Rothacker; Edouard C Nice; Kenneth W Harder; Sally Roufail; Margaret L Hibbs; Peter A W Rogers; Kari Alitalo; Steven A Stacker; Marc G Achen
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(4):1088-98.
2007: Steven A Stacker; Rae H Farnsworth; Tara Karnezis; Ramin Shayan; Darrin P Smith; Karri Paavonen; Natalia Davydova; Carol Caesar; Rachael Inder; Megan E Baldwin; Bradley K McColl; Sally Roufail; Richard A Williams; Richard A Hughes; Kari Alitalo; Marc G Achen
Molecular pathways for lymphangiogenesis and their role in human disease.
Novartis Foundation symposium 2007;281():38-43; discussion 44-53, 208-9.
2006: Marc G Achen; Steven A Stacker
Tumor lymphangiogenesis and metastatic spread-new players begin to emerge.
International journal of cancer. Journal international du cancer 2006;119(8):1755-60.
2006: Ramin Shayan; Marc G Achen; Steven A Stacker
Lymphatic vessels in cancer metastasis: bridging the gaps.
Carcinogenesis 2006;27(9):1729-38.
2006: Terhi Karpanen; Maria Wirzenius; Taija Mäkinen; Tanja Veikkola; Hidde J Haisma; Marc G Achen; Steven A Stacker; Bronislaw Pytowski; Seppo Ylä-Herttuala; Kari Alitalo
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
The American journal of pathology 2006;169(2):708-18.
2006: Marc G Achen; G B Mann; Steven A Stacker
Targeting lymphangiogenesis to prevent tumour metastasis.
British journal of cancer 2006;94(10):1355-60.
2006: Steven A Stacker; R A Hughes; Richard A Williams; Marc G Achen
Current strategies for modulating lymphangiogenesis signalling pathways in human disease.
Current medicinal chemistry 2006;13(7):783-92.
2006: Rae H Farnsworth; Marc G Achen; Steven A Stacker
Lymphatic endothelium: an important interactive surface for malignant cells.
Pulmonary pharmacology & therapeutics 2006;19(1):51-60.
2005: Bradley K McColl; Stephen J Loughran; Natalia Davydova; Steven A Stacker; Marc G Achen
Mechanisms of lymphangiogenesis: targets for blocking the metastatic spread of cancer.
Current cancer drug targets 2005;5(8):561-71.
2005: Zofia von Marschall; Arne Scholz; Steven A Stacker; Marc G Achen; David G Jackson; Frauke Alves; Michael Schirner; Martin Haberey; Karl-Heinz Thierauch; Bertram Wiedenmann; Stefan Rosewicz
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer.
International journal of oncology 2005;27(3):669-79.
2005: Juha Rutanen; Anna-Mari Turunen; M Teittinen; Tuomas T Rissanen; Tommi Heikura; Jonna K Koponen; Marcin Gruchala; Matias Inkala; Suvi Jauhiainen; Mikko O Hiltunen; Mikko Turunen; Steven A Stacker; Marc G Achen; Seppo Ylä-Herttuala
Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism.
Gene therapy 2005;12(12):980-7.
2005: Megan E Baldwin; Michael M Halford; Sally Roufail; Richard A Williams; Margaret L Hibbs; Dianne Grail; Hajime Kubo; Steven A Stacker; Marc G Achen
Vascular endothelial growth factor D is dispensable for development of the lymphatic system.
Molecular and cellular biology 2005;25(6):2441-9.
2005: Marc G Achen; Bradley K McColl; Steven A Stacker
Focus on lymphangiogenesis in tumor metastasis.
Cancer cell 2005;7(2):121-7.
2005: Peter Baluk; Tuomas Tammela; Erin Ator; Natalya Lyubynska; Marc G Achen; Daniel J Hicklin; Michael Jeltsch; Tatiana V Petrova; Bronislaw Pytowski; Steven A Stacker; Seppo Ylä-Herttuala; David G Jackson; Kari Alitalo; Donald M McDonald
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
The Journal of clinical investigation 2005;115(2):247-57.
2004: Yiping Zeng; Kenneth Opeskin; Megan E Baldwin; Lisa G Horvath; Marc G Achen; Steven A Stacker; Robert L Sutherland; Elizabeth D Williams
Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5137-44.
2004: Steven A Stacker; Richard A Williams; Marc G Achen
Lymphangiogenic growth factors as markers of tumor metastasis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2004;112(7-8):539-49.
2004: Bradley K McColl; Steven A Stacker; Marc G Achen
Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2004;112(7-8):463-80.
2004: Juha Rutanen; Tuomas T Rissanen; Johanna E Markkanen; Marcin Gruchala; Päivi Silvennoinen; Antti Kivelä; Antti Hedman; Marja Hedman; Tommi Heikura; Maija-Riitta Ordén; Steven A Stacker; Marc G Achen; Juha Hartikainen; Seppo Ylä-Herttuala
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart.
Circulation 2004;109(8):1029-35.
2004: Steven A Stacker; R A Hughes; Marc G Achen
Molecular targeting of lymphatics for therapy.
Current pharmaceutical design 2004;10(1):65-74.
2003: Shalini Bhardwaj; Himadri Roy; Marcin Gruchala; Helena Viita; Ivana Kholova; Ilze Kokina; Marc G Achen; Steven A Stacker; Marja Hedman; Kari Alitalo; Seppo Ylä-Herttuala
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Human gene therapy 2003;14(15):1451-62.
2003: Juha Rutanen; Pia Leppänen; Tiina T Tuomisto; Tuomas T Rissanen; Mikko O Hiltunen; Ismo Vajanto; Mari Niemi; Tomi P Häkkinen; Kari Karkola; Steven A Stacker; Marc G Achen; Kari Alitalo; Seppo Ylä-Herttuala
Vascular endothelial growth factor-D expression in human atherosclerotic lesions.
Cardiovascular research 2003;59(4):971-9.
2003: Lyn M Wise; Norihito Ueda; Nicola H Dryden; Stephen B Fleming; Carol Caesar; Sally Roufail; Marc G Achen; Steven A Stacker; Andrew A Mercer
Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens.
The Journal of biological chemistry 2003;278(39):38004-14.
2003: Bradley K McColl; Megan E Baldwin; Sally Roufail; Craig Freeman; Robert L Moritz; Richard J Simpson; Kari Alitalo; Steven A Stacker; Marc G Achen
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
The Journal of experimental medicine 2003;198(6):863-8.
2003: Tuomas T Rissanen; Johanna E Markkanen; Marcin Gruchala; Tommi Heikura; Antti Puranen; Mikko I Kettunen; Ivana Kholová; Risto A Kauppinen; Marc G Achen; Steven A Stacker; Kari Alitalo; Seppo Ylä-Herttuala
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.
Circulation research 2003;92(10):1098-106.
2003: Christopher B Daniels; Benjamin C Lewis; Chris Tsopelas; Suzanne L Munns; Sandra Orgeig; Megan E Baldwin; Steven A Stacker; Marc G Achen; Barry E Chatterton; Rodney D Cooter
Regenerating lizard tails: a new model for investigating lymphangiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):479-81.
2002: Megan E Baldwin; Steven A Stacker; Marc G Achen
Molecular control of lymphangiogenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(11):1030-40.
2002: Steven A Stacker; Marc G Achen; Lotta Jussila; Megan E Baldwin; Kari Alitalo
Lymphangiogenesis and cancer metastasis.
Nature reviews. Cancer 2002;2(8):573-83.
2002: Steven A Stacker; Megan E Baldwin; Marc G Achen
The role of tumor lymphangiogenesis in metastatic spread.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):922-34.
2002: Tatiana V Byzova; Corey K Goldman; Jurek Jankau; Juhua Chen; Gustavo Cabrera; Marc G Achen; Steven A Stacker; Kevin Carnevale; Maria Siemionow; Steven R Deitcher; Paul E DiCorleto
Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.
Blood 2002;99(12):4434-42.
2002: Marc G Achen; Richard A Williams; Megan E Baldwin; Patricia Lai; Sally Roufail; Kari Alitalo; Steven A Stacker
The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer.
Growth factors (Chur, Switzerland) 2002;20(2):99-107.
2001: Megan E Baldwin; Sally Roufail; Michael M Halford; Kari Alitalo; Steven A Stacker; Marc G Achen
Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis.
The Journal of biological chemistry 2001;276(47):44307-14.
2001: Taija Mäkinen; Tanja Veikkola; Satu Mustjoki; Terhi Karpanen; Bruno Catimel; Edouard C Nice; L Wise; Andrew A Mercer; H Kowalski; Dontscho Kerjaschki; Steven A Stacker; Marc G Achen; Kari Alitalo
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.
The EMBO journal 2001;20(17):4762-73.
2001: Waldemar Debinski; Becky Slagle-Webb; Marc G Achen; Steven A Stacker; E Tulchinsky; GY Gillespie; Denise M Gibo
VEGF-D is an X-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme.
Molecular medicine (Cambridge, Mass.) 2001;7(9):598-608.
2001: Megan E Baldwin; Bruno Catimel; Edouard C Nice; Sally Roufail; Nathan E Hall; Kaye L Stenvers; M J Karkkainen; Kari Alitalo; Steven A Stacker; Marc G Achen
The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man.
The Journal of biological chemistry 2001;276(22):19166-71.
2001: Tanja Veikkola; Lotta Jussila; Taija Makinen; Terhi Karpanen; Michael Jeltsch; Tatiana V Petrova; Hajime Kubo; G Thurston; Donald M McDonald; Marc G Achen; Steven A Stacker; Kari Alitalo
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.
The EMBO journal 2001;20(6):1223-31.
2001: Marc G Achen; Richard A Williams; M P Minekus; G E Thornton; Kaye L Stenvers; Peter A W Rogers; F Lederman; Sally Roufail; Steven A Stacker
Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis.
The Journal of pathology 2001;193(2):147-54.
2001: Steven A Stacker; Carol Caesar; Megan E Baldwin; G E Thornton; Richard A Williams; Remko Prevo; David G Jackson; S Nishikawa; Hajime Kubo; Marc G Achen
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics.
Nature medicine 2001;7(2):186-91.
2000: Taina A Partanen; Johanna Arola; Anne Saaristo; Lotta Jussila; Ari Ora; Markku Miettinen; Steven A Stacker; Marc G Achen; Kari Alitalo
VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):2087-96.
2000: Marc G Achen; Sally Roufail; Teresa Domagala; Bruno Catimel; Edouard C Nice; DM Geleick; Roger Murphy; Andrew M Scott; Carol Caesar; Taija Makinen; Kari Alitalo; Steven A Stacker
Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.
European journal of biochemistry / FEBS 2000;267(9):2505-15.
2000: A Lymboussaki; Marc G Achen; Steven A Stacker; Kari Alitalo
Growth factors regulating lymphatic vessels.
Current topics in microbiology and immunology 2000;251():75-82.
1999: Steven A Stacker; A Vitali; Carol Caesar; Teresa Domagala; L C Groenen; Edouard C Nice; Marc G Achen; Andrew Wilks
A mutant form of vascular endothelial growth factor (VEGF) that lacks VEGF receptor-2 activation retains the ability to induce vascular permeability.
The Journal of biological chemistry 1999;274(49):34884-92.
1999: Steven A Stacker; Kaye L Stenvers; Carol Caesar; A Vitali; Teresa Domagala; Edouard C Nice; Sally Roufail; Richard J Simpson; Robert L Moritz; Terhi Karpanen; Kari Alitalo; Marc G Achen
Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.
The Journal of biological chemistry 1999;274(45):32127-36.
1999: Steven A Stacker; Marc G Achen
The vascular endothelial growth factor family: signalling for vascular development.
Growth factors (Chur, Switzerland) 1999;17(1):1-11.
1998: Marc G Achen; Steven A Stacker
The vascular endothelial growth factor family; proteins which guide the development of the vasculature.
International journal of experimental pathology 1998;79(5):255-65.
1998: Andrew Oates; P Wollberg; Marc G Achen; Andrew Wilks
Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA.
Biochemical and biophysical research communications 1998;249(3):660-7.
1998: Marc G Achen; Michael Jeltsch; E Kukk; Taija Mäkinen; A Vitali; Andrew Wilks; Kari Alitalo; Steven A Stacker
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):548-53.
1997: N A Jenkins; E Woollatt; J Crawford; D J Gilbert; Megan E Baldwin; G R Sutherland; N G Copeland; Marc G Achen
Mapping of the gene for vascular endothelial growth factor-D in mouse and man to the X chromosome.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1997;5(7):502-5.
1997: Marc G Achen; JM Gad; Steven A Stacker; Andrew Wilks
Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development.
Growth factors (Chur, Switzerland) 1997;15(1):69-80.