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Joseph Heitman
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
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44
Perfect, John
37
Cardenas, Maria
31
Cox, Gary
17
Idnurm, Alexander
14
Fraser, James
13
Nielsen, Kirsten
11
Mitchell, Thomas
11
Cruz, Cristina
11
Bahn, Yong-Sun
10
Alspaugh, Andrew
10
Del Poeta, Maurizio
10
Wang, Ping
10
Lin, Xiaorong
10
Hull, Christina
9
Blankenship, Jill
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All Publications
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2009: Velagapudi Rajesh; Hsueh Yen-Ping; Geunes-Boyer Scarlett; Wright Jo Rae; Heitman Joseph
Spores as infectious propagules of Cryptococcus neoformans.
Infection and immunity 2009;77(10):4345-55.
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2009: Lee Soo Chan; Weiss Louis M; Heitman Joseph
Generation of genetic diversity in microsporidia via sexual reproduction and horizontal gene transfer.
Communicative & integrative biology 2009;2(5):414-7.
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2009: Ko Young-Joon; Yu Yeong Man; Kim Gyu-Bum; Lee Gir-Won; Maeng Pil Jae; Kim Sangsoo; Floyd Anna; Heitman Joseph; Bahn Yong-Sun
Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways.
Eukaryotic cell 2009;8(8):1197-217.
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2009: Reedy Jennifer L; Floyd Anna M; Heitman Joseph
Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex.
Current biology : CB 2009;19(11):891-9.
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2009: Hsueh Yen-Ping; Xue Chaoyang; Heitman Joseph
A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans.
The EMBO journal 2009;28(9):1220-33.
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2009: Sanz Catalina; Rodríguez-Romero Julio; Idnurm Alexander; Christie John M; Heitman Joseph; Corrochano Luis M; Eslava Arturo P
Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7095-100.
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2009: Pinchai Nadthanan; Perfect B Zachary; Juvvadi Praveen Rao; Fortwendel Jarrod R; Cramer Robert A; Asfaw Yohannes G; Heitman Joseph; Perfect John R; Steinbach William J
Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.
Eukaryotic cell 2009;8(4):511-9.
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2009: Byrnes Edmond J; Bildfell Robert J; Frank Sheryl A; Mitchell Thomas G; Marr Kieren A; Heitman Joseph
Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States.
The Journal of infectious diseases 2009;199(7):1081-6.
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2009: Semighini Camile P; Heitman Joseph
Dynamic duo takes down fungal villains.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):2971-2.
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2009: Kozubowski Lukasz; Lee Soo Chan; Heitman Joseph
Signalling pathways in the pathogenesis of Cryptococcus.
Cellular microbiology 2009;11(3):370-80.
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2009: Bastidas Robert J; Heitman Joseph; Cardenas Maria E
The protein kinase Tor1 regulates adhesin gene expression in Candida albicans.
PLoS pathogens 2009;5(2):e1000294.
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2009: Lin Xiaorong; Patel Sweta; Litvintseva Anastasia P; Floyd Anna; Mitchell Thomas G; Heitman Joseph
Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating.
PLoS pathogens 2009;5(1):e1000283.
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2009: Bastidas Robert J; Heitman Joseph
Trimorphic stepping stones pave the way to fungal virulence.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):351-2.
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2009: Byrnes Edmond J; Li Wenjun; Lewit Yonathan; Perfect John R; Carter Dee A; Cox Gary M; Heitman Joseph
First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen.
PloS one 2009;4(6):e5851.
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2008: Hsueh Yen-Ping; Heitman Joseph
Orchestration of sexual reproduction and virulence by the fungal mating-type locus.
Current opinion in microbiology 2008;11(6):517-24.
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2008: Lee Soo Chan; Corradi Nicolas; Byrnes Edmond J; Torres-Martinez Santiago; Dietrich Fred S; Keeling Patrick J; Heitman Joseph
Microsporidia evolved from ancestral sexual fungi.
Current biology : CB 2008;18(21):1675-9.
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2008: Xue Chaoyang; Hsueh Yen-Ping; Heitman Joseph
Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi.
FEMS microbiology reviews 2008;32(6):1010-32.
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2008: Xue Chaoyang; Hsueh Yen-Ping; Chen Lydia; Heitman Joseph
The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans.
Molecular microbiology 2008;70(2):379-95.
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2008: Hsueh Yen-Ping; Fraser James A; Heitman Joseph
Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans.
Eukaryotic cell 2008;7(10):1847-55.
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2008: Bui Tien; Lin Xiaorong; Malik Richard; Heitman Joseph; Carter Dee
Isolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations.
Eukaryotic cell 2008;7(10):1771-80.
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2008: Singh Nina; Lortholary Olivier; Dromer Françoise; Alexander Barbara D; Gupta Krishan L; John George T; del Busto Ramon; Klintmalm Goran B; Somani Jyoti; Lyon G Marshall; Pursell Kenneth; Stosor Valentina; Munoz Patricia; Limaye Ajit P; Kalil Andre C; Pruett Timothy L; Garcia-Diaz Julia; Humar Atul; Houston Sally; House Andrew A; Wray Dannah; Orloff Susan; Dowdy Lorraine A; Fisher Robert A; Heitman Joseph; Wagener Marilyn M; Husain Shahid;
Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings.
Transplantation 2008;86(5):647-51.
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2008: Juvvadi Praveen Rao; Fortwendel Jarrod R; Pinchai Nadthanan; Perfect B Zachary; Heitman Joseph; Steinbach William J
Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.
Eukaryotic cell 2008;7(9):1606-10.
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2008: Bastidas Robert J; Reedy Jennifer L; Morales-Johansson Helena; Heitman Joseph; Cardenas Maria E
Signaling cascades as drug targets in model and pathogenic fungi.
Current opinion in investigational drugs (London, England : 2000) 2008;9(8):856-64.
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2008: Cramer Robert A; Perfect B Zachary; Pinchai Nadthanan; Park Steven; Perlin David S; Asfaw Yohannes G; Heitman Joseph; Perfect John R; Steinbach William J
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
Eukaryotic cell 2008;7(7):1085-97.
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2008: Rutherford Julian C; Chua Gordon; Hughes Timothy; Cardenas Maria E; Heitman Joseph
A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae.
Molecular biology of the cell 2008;19(7):3028-39.
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2008: Lin Xiaorong; Nielsen Kirsten; Patel Sweta; Heitman Joseph
Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans.
Infection and immunity 2008;76(7):2923-38.
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2008: Uppuluri Priya; Nett Jeniel; Heitman Joseph; Andes David
Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.
Antimicrobial agents and chemotherapy 2008;52(3):1127-32.
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2008: Teichert Sabine; Rutherford Julian C; Wottawa Marieke; Heitman Joseph; Tudzynski Bettina
Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi.
Eukaryotic cell 2008;7(2):187-201.
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2008: Kontoyiannis Dimitrios P; Lewis Russell E; Alexander Barbara D; Lortholary Olivier; Dromer Françoise; Gupta Krishan L; John George T; Del Busto Ramon; Klintmalm Goran B; Somani Jyoti; Lyon G Marshall; Pursell Kenneth; Stosor Valentina; Munoz Patricia; Limaye Ajit P; Kalil Andre C; Pruett Timothy L; Garcia-Diaz Julia; Humar Atul; Houston Sally; House Andrew A; Wray Dannah; Orloff Susan; Dowdy Lorraine A; Fisher Robert A; Heitman Joseph; Albert Nathaniel D; Wagener Marilyn M; Singh Nina
Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.
Antimicrobial agents and chemotherapy 2008;52(2):735-8.
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2008: Rutherford Julian C; Lin Xiaorong; Nielsen Kirsten; Heitman Joseph
Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans.
Eukaryotic cell 2008;7(2):237-46.
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2008: Heitman Joseph; Howlett Barbara
Fungal horizons: the Asilomar Fungal Genetics Conference 2007.
Fungal genetics and biology : FG & B 2008;45(2):77-83.
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2008: Idnurm Alexander; Walton Felicia J; Floyd Anna; Heitman Joseph
Identification of the sex genes in an early diverged fungus.
Nature 2008;451(7175):193-6.
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2008: Singh Nina; Alexander Barbara D; Lortholary Olivier; Dromer Françoise; Gupta Krishan L; John George T; del Busto Ramon; Klintmalm Goran B; Somani Jyoti; Lyon G Marshall; Pursell Kenneth; Stosor Valentina; Muñoz Patricia; Limaye Ajit P; Kalil Andre C; Pruett Timothy L; Garcia-Diaz Julia; Humar Atul; Houston Sally; House Andrew A; Wray Dannah; Orloff Susan; Dowdy Lorraine A; Fisher Robert A; Heitman Joseph; Wagener Marilyn M; Husain Shahid
Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(2):e12-8.
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2007: Bahn Yong-Sun; Geunes-Boyer Scarlett; Heitman Joseph
Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.
Eukaryotic cell 2007;6(12):2278-89.
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2007: Lin Xiaorong; Litvintseva Anastasia P; Nielsen Kirsten; Patel Sweta; Floyd Anna; Mitchell Thomas G; Heitman Joseph
alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness.
PLoS genetics 2007;3(10):1975-90.
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2007: Onyewu Chiatogu; Eads Emily; Schell Wiley A; Perfect John R; Ullmann Yehuda; Kaufman Gil; Horwitz Benjamin A; Berdicevsky Israela; Heitman Joseph
Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
Antimicrobial agents and chemotherapy 2007;51(10):3743-6.
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2007: Upton Arlo; Fraser James A; Kidd Sarah E; Bretz Camille; Bartlett Karen H; Heitman Joseph; Marr Kieren A
First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak.
Journal of clinical microbiology 2007;45(9):3086-8.
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2007: Hsueh Yen-Ping; Xue Chaoyang; Heitman Joseph
G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans.
Molecular biology of the cell 2007;18(9):3237-49.
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2007: Reedy Jennifer L; Bastidas Robert J; Heitman Joseph
The virulence of human pathogenic fungi: notes from the South of France.
Cell host & microbe 2007;2(2):77-83.
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2007: Litvintseva Anastasia P; Lin Xiaorong; Templeton Irka; Heitman Joseph; Mitchell Thomas G
Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa.
PLoS pathogens 2007;3(8):e114.
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2007: Steinbach William J; Cramer Robert A; Perfect B Zachary; Henn Christina; Nielsen Kirsten; Heitman Joseph; Perfect John R
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2007;51(8):2979-81.
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2007: Fan Weihua; Idnurm Alexander; Breger Julia; Mylonakis Eleftherios; Heitman Joseph
Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans.
Infection and immunity 2007;75(7):3394-405.
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2007: Xue Chaoyang; Tada Yasuomi; Dong Xinnian; Heitman Joseph
The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants.
Cell host & microbe 2007;1(4):263-73.
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2007: Valdivia Raphael H; Heitman Joseph
Endosymbiosis: the evil within.
Current biology : CB 2007;17(11):R408-10.
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2007: Steinbach William J; Reedy Jennifer L; Cramer Robert A; Perfect John R; Heitman Joseph
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
Nature reviews. Microbiology 2007;5(6):418-30.
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2007: Nielsen Kirsten; De Obaldia Anna L; Heitman Joseph
Cryptococcus neoformans mates on pigeon guano: implications for the realized ecological niche and globalization.
Eukaryotic cell 2007;6(6):949-59.
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2007: Chuluunbaatar Tungalag; Ivanenko-Johnston Tetiana; Fuxreiter Mónika; Meleshko Ruslan; Raskó Tamás; Simon István; Heitman Joseph; Kiss Antal
An EcoRI-RsrI chimeric restriction endonuclease retains parental sequence specificity.
Biochimica et biophysica acta 2007;1774(5):583-94.
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2007: Fraser James A; Stajich Jason E; Tarcha Eric J; Cole Garry T; Inglis Diane O; Sil Anita; Heitman Joseph
Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii.
Eukaryotic cell 2007;6(4):622-9.
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2007: Singh Nina; Alexander Barbara D; Lortholary Olivier; Dromer Francoise; Gupta Krishan L; John George T; del Busto Ramon; Klintmalm Goran B; Somani Jyoti; Lyon G Marshall; Pursell Kenneth; Stosor Valentina; Munoz Patricia; Limaye Ajit P; Kalil Andre C; Pruett Timothy L; Garcia-Diaz Julia; Humar Atul; Houston Sally; House Andrew A; Wray Dannah; Orloff Susan; Dowdy Lorraine A; Fisher Robert A; Heitman Joseph; Wagener Marilyn M; Husain Shahid;
Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality.
The Journal of infectious diseases 2007;195(5):756-64.
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2007: Hicks Julie K; Heitman Joseph
Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade.
Eukaryotic cell 2007;6(3):413-20.
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2007: Yan Zhun; Hull Christina M; Sun Sheng; Heitman Joseph; Xu Jianping
The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans.
Current genetics 2007;51(3):187-95.
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2007: Howlett Barbara J; Idnurm Alexander; Heitman Joseph
Fungal pathogenesis: gene clusters unveiled as secrets within the Ustilago maydis code.
Current biology : CB 2007;17(3):R87-90.
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2007: Bahn Yong-Sun; Xue Chaoyang; Idnurm Alexander; Rutherford Julian C; Heitman Joseph; Cardenas Maria E
Sensing the environment: lessons from fungi.
Nature reviews. Microbiology 2007;5(1):57-69.
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2007: Idnurm Alexander; Giles Steven S; Perfect John R; Heitman Joseph
Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans.
Eukaryotic cell 2007;6(1):60-72.
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2007: Nielsen Kirsten; Heitman Joseph
Sex and virulence of human pathogenic fungi.
Advances in genetics 2007;57():143-73.
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2006: Lin Xiaorong; Huang Johnny C; Mitchell Thomas G; Heitman Joseph
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation.
PLoS genetics 2006;2(11):e187.
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2006: Hsueh Yen-Ping; Idnurm Alexander; Heitman Joseph
Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome.
PLoS genetics 2006;2(11):e184.
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2006: Onyewu Chiatogu; Afshari Natalie A; Heitman Joseph
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
Antimicrobial agents and chemotherapy 2006;50(11):3963-5.
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2006: Heitman Joseph
Sexual reproduction and the evolution of microbial pathogens.
Current biology : CB 2006;16(17):R711-25.
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2006: Walton Felicia J; Heitman Joseph; Idnurm Alexander
Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi.
Molecular biology of the cell 2006;17(9):3768-80.
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2006: Steinbach William J; Cramer Robert A; Perfect B Zachary; Asfaw Yohannes G; Sauer Theodor C; Najvar Laura K; Kirkpatrick William R; Patterson Thomas F; Benjamin Daniel K; Heitman Joseph; Perfect John R
Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
Eukaryotic cell 2006;5(7):1091-103.
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2006: Bahn Yong-Sun; Kojima Kaihei; Cox Gary M; Heitman Joseph
A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans.
Molecular biology of the cell 2006;17(7):3122-35.
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2006: Harashima Toshiaki; Anderson Scott; Yates John R; Heitman Joseph
The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2.
Molecular cell 2006;22(6):819-30.
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2006: Fraser James A; Lim Shirlene M C; Diezmann Stephanie; Wenink Emily C; Arndt Cristl G; Cox Gary M; Dietrich Fred S; Heitman Joseph
Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale.
FEMS yeast research 2006;6(4):620-4.
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2006: Reedy Jennifer L; Husain Shahid; Ison Michael; Pruett Timothy L; Singh Nina; Heitman Joseph
Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.
Antimicrobial agents and chemotherapy 2006;50(4):1573-7.
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2006: Idnurm Alexander; Rodríguez-Romero Julio; Corrochano Luis M; Sanz Catalina; Iturriaga Enrique A; Eslava Arturo P; Heitman Joseph
The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4546-51.
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2006: Kojima Kaihei; Bahn Yong-Sun; Heitman Joseph
Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans.
Microbiology (Reading, England) 2006;152(Pt 3):591-604.
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2006: Xue Chaoyang; Bahn Yong-Sun; Cox Gary M; Heitman Joseph
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
Molecular biology of the cell 2006;17(2):667-79.
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2006: Lin Xiaorong; Heitman Joseph
The biology of the Cryptococcus neoformans species complex.
Annual review of microbiology 2006;60():69-105.
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2005: Hicks Julie K; Bahn Yong-Sun; Heitman Joseph
Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans.
Eukaryotic cell 2005;4(12):1971-81.
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2005: Tang Robin J; Breger Julia; Idnurm Alexander; Gerik Kimberly J; Lodge Jennifer K; Heitman Joseph; Calderwood Stephen B; Mylonakis Eleftherios
Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach.
Infection and immunity 2005;73(12):8219-25.
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2005: Fraser James A; Heitman Joseph
Chromosomal sex-determining regions in animals, plants and fungi.
Current opinion in genetics & development 2005;15(6):645-51.
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2005: Bahn Yong-Sun; Cox Gary M; Perfect John R; Heitman Joseph
Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence.
Current biology : CB 2005;15(22):2013-20.
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2005: Nielsen Kirsten; Marra Robert E; Hagen Ferry; Boekhout Teun; Mitchell Thomas G; Cox Gary M; Heitman Joseph
Interaction between genetic background and the mating-type locus in Cryptococcus neoformans virulence potential.
Genetics 2005;171(3):975-83.
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2005: Singh Nina; Lortholary Olivier; Alexander Barbara D; Gupta Krishan L; John George T; Pursell Kenneth J; Muñoz Patricia; Klintmalm Goran B; Stosor Valentina; Del Busto Ramon; Limaye Ajit P; Somani Jyoti; Lyon Marshall; Houston Sally; House Andrew A; Pruett Timothy L; Orloff Susan; Humar Atul; Dowdy Lorraine A; Garcia-Diaz Julia; Kalil Andre C; Fisher Robert A; Heitman Joseph; Husain Shahid
Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infection.
Transplantation 2005;80(8):1033-9.
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2005: Idnurm Alexander; Heitman Joseph
Photosensing fungi: phytochrome in the spotlight.
Current biology : CB 2005;15(20):R829-32.
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2005: Fraser James A; Giles Steven S; Wenink Emily C; Geunes-Boyer Scarlett G; Wright Jo Rae; Diezmann Stephanie; Allen Andria; Stajich Jason E; Dietrich Fred S; Perfect John R; Heitman Joseph
Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak.
Nature 2005;437(7063):1360-4.
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2005: Lin Xiaorong; Heitman Joseph
Chlamydospore formation during hyphal growth in Cryptococcus neoformans.
Eukaryotic cell 2005;4(10):1746-54.
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2005: Idnurm Alexander; Bahn Yong-Sun; Nielsen Kirsten; Lin Xiaorong; Fraser James A; Heitman Joseph
Deciphering the model pathogenic fungus Cryptococcus neoformans.
Nature reviews. Microbiology 2005;3(10):753-64.
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2005: Harashima Toshiaki; Heitman Joseph
Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae.
Molecular biology of the cell 2005;16(10):4557-71.
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2005: Gugnani H C; Mitchell T G; Litvintseva A P; Lengeler K B; Heitman J; Kumar A; Basu S; Paliwal-Joshi A
Isolation of Cryptococcus gattii and Cryptococcus neoformans var. grubii from the flowers and bark of Eucalyptus trees in India.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(6):565-9.
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2005: Heitman Joseph
Cell biology. A fungal Achilles' heel.
Science (New York, N.Y.) 2005;309(5744):2175-6.
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2005: Fox Deborah S; Heitman Joseph
Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans.
Eukaryotic cell 2005;4(9):1526-38.
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2005: Blankenship Jill R; Heitman Joseph
Calcineurin is required for Candida albicans to survive calcium stress in serum.
Infection and immunity 2005;73(9):5767-74.
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2005: Walton Felicia J; Idnurm Alexander; Heitman Joseph
Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans.
Molecular microbiology 2005;57(5):1381-96.
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2005: Fan Weihua; Kraus Peter R; Boily Marie-Josee; Heitman Joseph
Cryptococcus neoformans gene expression during murine macrophage infection.
Eukaryotic cell 2005;4(8):1420-33.
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2005: Campbell Leona T; Fraser James A; Nichols Connie B; Dietrich Fred S; Carter Dee; Heitman Joseph
Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity.
Eukaryotic cell 2005;4(8):1410-9.
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2005: Campbell Leona T; Currie Bart J; Krockenberger Mark; Malik Richard; Meyer Wieland; Heitman Joseph; Carter Dee
Clonality and recombination in genetically differentiated subgroups of Cryptococcus gattii.
Eukaryotic cell 2005;4(8):1403-9.
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2005: Nielsen Kirsten; Cox Gary M; Litvintseva Anastasia P; Mylonakis Eleftherios; Malliaris Stephanie D; Benjamin Daniel K; Giles Steven S; Mitchell Thomas G; Casadevall Arturo; Perfect John R; Heitman Joseph
Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection.
Infection and immunity 2005;73(8):4922-33.
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2005: Heitman Joseph; Cullen Bryan R
Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel?
Molecular cell 2005;19(2):145-6.
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2005: Mylonakis Eleftherios; Moreno Roberto; El Khoury Joseph B; Idnurm Alexander; Heitman Joseph; Calderwood Stephen B; Ausubel Frederick M; Diener Andrew
Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.
Infection and immunity 2005;73(7):3842-50.
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2005: Kraus Peter R; Nichols Connie B; Heitman Joseph
Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth.
Eukaryotic cell 2005;4(6):1079-87.
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2005: Bahn Yong-Sun; Kojima Kaihei; Cox Gary M; Heitman Joseph
Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans.
Molecular biology of the cell 2005;16(5):2285-300.
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2005: Lin Xiaorong; Hull Christina M; Heitman Joseph
Sexual reproduction between partners of the same mating type in Cryptococcus neoformans.
Nature 2005;434(7036):1017-21.
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2005: Idnurm Alexander; Heitman Joseph
Light controls growth and development via a conserved pathway in the fungal kingdom.
PLoS biology 2005;3(4):e95.
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2005: Hull Christina M; Boily Marie-Josee; Heitman Joseph
Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans.
Eukaryotic cell 2005;4(3):526-35.
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2005: Fraser James A; Huang Johnny C; Pukkila-Worley Read; Alspaugh J Andrew; Mitchell Thomas G; Heitman Joseph
Chromosomal translocation and segmental duplication in Cryptococcus neoformans.
Eukaryotic cell 2005;4(2):401-6.
-
2005: Pukkila-Worley Read; Gerrald Quincy D; Kraus Peter R; Boily Marie-Josée; Davis Matthew J; Giles Steven S; Cox Gary M; Heitman Joseph; Alspaugh J Andrew
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade.
Eukaryotic cell 2005;4(1):190-201.
-
2005: Arévalo-Rodríguez Miguel; Heitman Joseph
Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.
Eukaryotic cell 2005;4(1):17-29.
-
2005: Blankenship Jill R; Singh Nina; Alexander Barbara D; Heitman Joseph
Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.
Journal of clinical microbiology 2005;43(1):464-7.
-
2005: Wang Ping; Heitman Joseph
The cyclophilins.
Genome biology 2005;6(7):226.
-
2004: Bahn Yong-Sun; Hicks Julie K; Giles Steven S; Cox Gary M; Heitman Joseph
Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade.
Eukaryotic cell 2004;3(6):1476-91.
-
2004: Steinbach William J; Singh Nina; Miller Jackie L; Benjamin Daniel K; Schell Wiley A; Heitman Joseph; Perfect John R
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
Antimicrobial agents and chemotherapy 2004;48(12):4922-5.
-
2004: Onyewu Chiatogu; Wormley Floyd L; Perfect John R; Heitman Joseph
The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
Infection and immunity 2004;72(12):7330-3.
-
2004: Fraser James A; Diezmann Stephanie; Subaran Ryan L; Allen Andria; Lengeler Klaus B; Dietrich Fred S; Heitman Joseph
Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms.
PLoS biology 2004;2(12):e384.
-
2004: Wang Ping; Cox Gary M; Heitman Joseph
A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans.
Current genetics 2004;46(5):247-55.
-
2004: Arévalo-Rodríguez Miguel; Pan Xuewen; Boeke Jef D; Heitman Joseph
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
Eukaryotic cell 2004;3(5):1287-96.
-
2004: Kraus Peter R; Boily Marie-Josée; Giles Steven S; Stajich Jason E; Allen Andria; Cox Gary M; Dietrich Fred S; Perfect John R; Heitman Joseph
Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.
Eukaryotic cell 2004;3(5):1249-60.
-
2004: Mylonakis Eleftherios; Idnurm Alexander; Moreno Roberto; El Khoury Joseph; Rottman James B; Ausubel Frederick M; Heitman Joseph; Calderwood Stephen B
Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals.
Molecular microbiology 2004;54(2):407-19.
-
2004: Toffaletti Dena L; Nielsen Kirsten; Dietrich Fred; Heitman Joseph; Perfect John R
Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence.
Current genetics 2004;46(4):193-204.
-
2004: Nichols Connie B; Fraser James A; Heitman Joseph
PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans.
Molecular biology of the cell 2004;15(10):4476-89.
-
2004: Yan Zhun; Hull Christina M; Heitman Joseph; Sun Sheng; Xu Jianping
SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans.
Current biology : CB 2004;14(18):R743-4.
-
2004: Arevalo-Rodriguez Miguel; Wu Xiaoyun; Hanes Steven D; Heitman Joseph
Prolyl isomerases in yeast.
Frontiers in bioscience : a journal and virtual library 2004;9():2420-46.
-
2004: D'Souza Cletus A; Hagen Ferry; Boekhout Teun; Cox Gary M; Heitman Joseph
Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals.
Current genetics 2004;46(2):92-102.
-
2004: Marra Robert E; Huang Johnny C; Fung Eula; Nielsen Kirsten; Heitman Joseph; Vilgalys Rytas; Mitchell Thomas G
A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans).
Genetics 2004;167(2):619-31.
-
2004: Hull Christina M; Cox Gary M; Heitman Joseph
The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans.
Infection and immunity 2004;72(6):3643-5.
-
2004: Steinbach William J; Schell Wiley A; Blankenship Jill R; Onyewu Chiatogu; Heitman Joseph; Perfect John R
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2004;48(5):1664-9.
-
2004: Idnurm Alexander; Reedy Jennifer L; Nussbaum Jesse C; Heitman Joseph
Cryptococcus neoformans virulence gene discovery through insertional mutagenesis.
Eukaryotic cell 2004;3(2):420-9.
-
2004: Apidianakis Yiorgos; Rahme Laurence G; Heitman Joseph; Ausubel Frederick M; Calderwood Stephen B; Mylonakis Eleftherios
Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.
Eukaryotic cell 2004;3(2):413-9.
-
2004: Aramburu José; Heitman Joseph; Crabtree Gerald R
Calcineurin: a central controller of signalling in eukaryotes.
EMBO reports 2004;5(4):343-8.
-
2004: Singh Nina; Heitman Joseph
Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients.
Transplantation 2004;77(6):795-800.
-
2004: Barreto de Oliveira M T; Boekhout T; Theelen B; Hagen F; Baroni F A; Lazera M S; Lengeler K B; Heitman J; Rivera I N G; Paula C R
Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil.
Journal of clinical microbiology 2004;42(3):1356-9.
-
2004: Hicks Julie K; D'Souza Cletus A; Cox Gary M; Heitman Joseph
Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans.
Eukaryotic cell 2004;3(1):14-26.
-
2004: Fraser James A; Heitman Joseph
Evolution of fungal sex chromosomes.
Molecular microbiology 2004;51(2):299-306.
-
2003: Litvintseva Anastasia P; Marra Robert E; Nielsen Kirsten; Heitman Joseph; Vilgalys Rytas; Mitchell Thomas G
Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa.
Eukaryotic cell 2003;2(6):1162-8.
-
2003: Kraus Peter R; Heitman Joseph
Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.
Biochemical and biophysical research communications 2003;311(4):1151-7.
-
2003: de Jesús-Berríos Marisol; Liu Limin; Nussbaum Jesse C; Cox Gary M; Stamler Jonathan S; Heitman Joseph
Enzymes that counteract nitrosative stress promote fungal virulence.
Current biology : CB 2003;13(22):1963-8.
-
2003: Fraser James A; Heitman Joseph
Fungal mating-type loci.
Current biology : CB 2003;13(20):R792-5.
-
2003: Fraser James A; Subaran Ryan L; Nichols Connie B; Heitman Joseph
Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada.
Eukaryotic cell 2003;2(5):1036-45.
-
2003: Fox Deborah S; Cox Gary M; Heitman Joseph
Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans.
Eukaryotic cell 2003;2(5):1025-35.
-
2003: Young Laura Y; Hull Christina M; Heitman Joseph
Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.
Antimicrobial agents and chemotherapy 2003;47(9):2717-24.
-
2003: Nielsen Kirsten; Cox Gary M; Wang Ping; Toffaletti Dena L; Perfect John R; Heitman Joseph
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.
Infection and immunity 2003;71(9):4831-41.
-
2003: Davidson Robert C; Nichols Connie B; Cox Gary M; Perfect John R; Heitman Joseph
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
Molecular microbiology 2003;49(2):469-85.
-
2003: Blankenship Jill R; Wormley Floyd L; Boyce Molly K; Schell Wiley A; Filler Scott G; Perfect John R; Heitman Joseph
Calcineurin is essential for Candida albicans survival in serum and virulence.
Eukaryotic cell 2003;2(3):422-30.
-
2003: Kraus Peter R; Fox Deborah S; Cox Gary M; Heitman Joseph
The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function.
Molecular microbiology 2003;48(5):1377-87.
-
2003: Onyewu Chiatogu; Blankenship Jill R; Del Poeta Maurizio; Heitman Joseph
Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.
Antimicrobial agents and chemotherapy 2003;47(3):956-64.
-
2003: Blankenship Jill R; Steinbach William J; Perfect John R; Heitman Joseph
Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.
Current opinion in investigational drugs (London, England : 2000) 2003;4(2):192-9.
-
2003: Waugh Michael S; Vallim Marcelo A; Heitman Joseph; Alspaugh J Andrew
Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans.
Fungal genetics and biology : FG & B 2003;38(1):110-21.
-
2002: Hull Christina M; Davidson Robert C; Heitman Joseph
Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha.
Genes & development 2002;16(23):3046-60.
-
2002: Hull Christina M; Heitman Joseph
Fungal mating: Candida albicans flips a switch to get in the mood.
Current biology : CB 2002;12(22):R782-4.
-
2002: Mylonakis Eleftherios; Ausubel Frederick M; Perfect John R; Heitman Joseph; Calderwood Stephen B
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15675-80.
-
2002: Lengeler Klaus B; Fox Deborah S; Fraser James A; Allen Andria; Forrester Keri; Dietrich Fred S; Heitman Joseph
Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes.
Eukaryotic cell 2002;1(5):704-18.
-
2002: Fox Deborah S; Heitman Joseph
Good fungi gone bad: the corruption of calcineurin.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(10):894-903.
-
2002: Schein Jacqueline E; Tangen Kristin L; Chiu Readman; Shin Heesun; Lengeler Klaus B; MacDonald William Kim; Bosdet Ian; Heitman Joseph; Jones Steven J M; Marra Marco A; Kronstad James W
Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans.
Genome research 2002;12(9):1445-53.
-
2002: Davidson Robert C; Blankenship Jill R; Kraus Peter R; de Jesus Berrios Marisol; Hull Christina M; D'Souza Cletus; Wang Ping; Heitman Joseph
A PCR-based strategy to generate integrative targeting alleles with large regions of homology.
Microbiology (Reading, England) 2002;148(Pt 8):2607-15.
-
2002: Harashima Toshiaki; Heitman Joseph
The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.
Molecular cell 2002;10(1):163-73.
-
2002: Shen Wei-Chiang; Davidson Robert C; Cox Gary M; Heitman Joseph
Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans.
Eukaryotic cell 2002;1(3):366-77.
-
2002: Xu Xuehong; Su Bing; Barndt Robert J; Chen Hanying; Xin Hongbo; Yan Guifan; Chen Linyuan; Cheng Dongsheng; Heitman Joseph; Zhuang Yuan; Fleischer Sidney; Shou Weinian
FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.
Transplantation 2002;73(11):1835-8.
-
2002: Pan Xuewen; Heitman Joseph
Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation.
Molecular and cellular biology 2002;22(12):3981-93.
-
2002: Wang Ping; Nichols Connie B; Lengeler Klaus B; Cardenas Maria E; Cox Gary M; Perfect John R; Heitman Joseph
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.
Eukaryotic cell 2002;1(2):257-72.
-
2002: Alspaugh J Andrew; Pukkila-Worley Read; Harashima Toshiaki; Cavallo Lora M; Funnell Deanna; Cox Gary M; Perfect John R; Kronstad James W; Heitman Joseph
Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.
Eukaryotic cell 2002;1(1):75-84.
-
2002: Cruz M Cristina; Goldstein Alan L; Blankenship Jill R; Del Poeta Maurizio; Davis Dana; Cardenas Maria E; Perfect John R; McCusker John H; Heitman Joseph
Calcineurin is essential for survival during membrane stress in Candida albicans.
The EMBO journal 2002;21(4):546-59.
-
2002: Waugh Michael S; Nichols Connie B; DeCesare Cameron M; Cox Gary M; Heitman Joseph; Alspaugh J Andrew
Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans.
Microbiology (Reading, England) 2002;148(Pt 1):191-201.
-
2002: Hull Christina M; Heitman Joseph
Genetics of Cryptococcus neoformans.
Annual review of genetics 2002;36():557-615.
-
2001: Cutler N S; Pan X; Heitman J; Cardenas M E
The TOR signal transduction cascade controls cellular differentiation in response to nutrients.
Molecular biology of the cell 2001;12(12):4103-13.
-
2001: D'Souza C A; Heitman J
It infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans.
The Journal of clinical investigation 2001;108(11):1577-8.
-
2001: Cruz M C; Goldstein A L; Blankenship J; Del Poeta M; Perfect J R; McCusker J H; Bennani Y L; Cardenas M E; Heitman J
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
Antimicrobial agents and chemotherapy 2001;45(11):3162-70.
-
2001: Wang P; Cardenas M E; Cox G M; Perfect J R; Heitman J
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.
EMBO reports 2001;2(6):511-8.
-
2001: D'Souza C A; Heitman J
Conserved cAMP signaling cascades regulate fungal development and virulence.
FEMS microbiology reviews 2001;25(3):349-64.
-
2001: D'Souza C A; Alspaugh J A; Yue C; Harashima T; Cox G M; Perfect J R; Heitman J
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
Molecular and cellular biology 2001;21(9):3179-91.
-
2001: Rohde J; Heitman J; Cardenas M E
The TOR kinases link nutrient sensing to cell growth.
The Journal of biological chemistry 2001;276(13):9583-6.
-
2001: Cruz M C; Fox D S; Heitman J
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.
The EMBO journal 2001;20(5):1020-32.
-
2001: Fox D S; Cruz M C; Sia R A; Ke H; Cox G M; Cardenas M E; Heitman J
Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.
Molecular microbiology 2001;39(4):835-49.
-
2001: Lengeler K B; Cox G M; Heitman J
Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus.
Infection and immunity 2001;69(1):115-22.
-
2000: Davidson R C; Moore T D; Odom A R; Heitman J
Characterization of the MFalpha pheromone of the human fungal pathogen cryptococcus neoformans.
Molecular microbiology 2000;38(5):1017-26.
-
2000: Pan X; Harashima T; Heitman J
Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.
Current opinion in microbiology 2000;3(6):567-72.
-
2000: Lengeler K B; Wang P; Cox G M; Perfect J R; Heitman J
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14455-60.
-
2000: Lengeler K B; Davidson R C; D'souza C; Harashima T; Shen W C; Wang P; Pan X; Waugh M; Heitman J
Signal transduction cascades regulating fungal development and virulence.
Microbiology and molecular biology reviews : MMBR 2000;64(4):746-85.
-
2000: Pan X; Heitman J
Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion.
Molecular and cellular biology 2000;20(22):8364-72.
-
2000: Arévalo-Rodríguez M; Cardenas M E; Wu X; Hanes S D; Heitman J
Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.
The EMBO journal 2000;19(14):3739-49.
-
2000: Wu X; Wilcox C B; Devasahayam G; Hackett R L; Arévalo-Rodríguez M; Cardenas M E; Heitman J; Hanes S D
The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.
The EMBO journal 2000;19(14):3727-38.
-
2000: Görlach J; Fox D S; Cutler N S; Cox G M; Perfect J R; Heitman J
Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
The EMBO journal 2000;19(14):3618-29.
-
2000: Chung N; Jenkins G; Hannun Y A; Heitman J; Obeid L M
Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis.
The Journal of biological chemistry 2000;275(23):17229-32.
-
2000: Young L Y; Lorenz M C; Heitman J
A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae.
Genetics 2000;155(1):17-29.
-
2000: Sia R A; Lengeler K B; Heitman J
Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic.
Fungal genetics and biology : FG & B 2000;29(3):153-63.
-
2000: Alspaugh J A; Cavallo L M; Perfect J R; Heitman J
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans.
Molecular microbiology 2000;36(2):352-65.
-
2000: Liu L; Zeng M; Hausladen A; Heitman J; Stamler J S
Protection from nitrosative stress by yeast flavohemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4672-6.
-
2000: Del Poeta M; Cruz M C; Cardenas M E; Perfect J R; Heitman J
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2000;44(3):739-46.
-
2000: Davidson R C; Cruz M C; Sia R A; Allen B; Alspaugh J A; Heitman J
Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans.
Fungal genetics and biology : FG & B 2000;29(1):38-48.
-
2000: Lorenz M C; Pan X; Harashima T; Cardenas M E; Xue Y; Hirsch J P; Heitman J
The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
Genetics 2000;154(2):609-22.
-
2000: Cruz M C; Sia R A; Olson M; Cox G M; Heitman J
Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
Infection and immunity 2000;68(2):982-5.
-
2000: Lorenz M C; Cutler N S; Heitman J
Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae.
Molecular biology of the cell 2000;11(1):183-99.
-
2000: Cruz M C; Del Poeta M; Wang P; Wenger R; Zenke G; Quesniaux V F; Movva N R; Perfect J R; Cardenas M E; Heitman J
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
Antimicrobial agents and chemotherapy 2000;44(1):143-9.
-
2000: Wang P; Perfect J R; Heitman J
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
Molecular and cellular biology 2000;20(1):352-62.
-
2000: Alspaugh J A; Davidson R C; Heitman J
Morphogenesis of Cryptococcus neoformans.
Contributions to microbiology 2000;5():217-38.
-
1999: Cardenas M E; Cutler N S; Lorenz M C; Di Como C J; Heitman J
The TOR signaling cascade regulates gene expression in response to nutrients.
Genes & development 1999;13(24):3271-9.
-
1999: Del Poeta M; Chen S F; Von Hoff D; Dykstra C C; Wani M C; Manikumar G; Heitman J; Wall M E; Perfect J R
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
Antimicrobial agents and chemotherapy 1999;43(12):2862-8.
-
1999: Yue C; Cavallo L M; Alspaugh J A; Wang P; Cox G M; Perfect J R; Heitman J
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.
Genetics 1999;153(4):1601-15.
-
1999: Cardenas M E; Cruz M C; Del Poeta M; Chung N; Perfect J R; Heitman J
Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.
Clinical microbiology reviews 1999;12(4):583-611.
-
1999: Heitman J; Allen B; Alspaugh J A; Kwon-Chung K J
On the origins of congenic MATalpha and MATa strains of the pathogenic yeast Cryptococcus neoformans.
Fungal genetics and biology : FG & B 1999;28(1):1-5.
-
1999: Cutler N S; Heitman J; Cardenas M E
TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.
Molecular and cellular endocrinology 1999;155(1-2):135-42.
-
1999: Heitman J; Ivanenko T; Kiss A
DNA nicks inflicted by restriction endonucleases are repaired by a RecA- and RecB-dependent pathway in Escherichia coli.
Molecular microbiology 1999;33(6):1141-51.
-
1999: Arndt C; Cruz M C; Cardenas M E; Heitman J
Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.
Microbiology (Reading, England) 1999;145 ( Pt 8)():1989-2000.
-
1999: Wang P; Heitman J
Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans.
Current opinion in microbiology 1999;2(4):358-62.
-
1999: Alarcon C M; Heitman J; Cardenas M E
Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
Molecular biology of the cell 1999;10(8):2531-46.
-
1999: Pan X; Heitman J
Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(7):4874-87.
-
1999: Joseph J D; Heitman J; Means A R
Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.
Fungal genetics and biology : FG & B 1999;27(1):55-66.
-
1999: Sudarshan S; Davidson R C; Heitman J; Alspaugh J A
Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption.
Fungal genetics and biology : FG & B 1999;27(1):36-48.
-
1999: Cruz M C; Cavallo L M; Görlach J M; Cox G; Perfect J R; Cardenas M E; Heitman J
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
Molecular and cellular biology 1999;19(6):4101-12.
-
1999: Del Poeta M; Toffaletti D L; Rude T H; Dykstra C C; Heitman J; Perfect J R
Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.
Genetics 1999;152(1):167-78.
-
1999: del Poeta M; Toffaletti D L; Rude T H; Sparks S D; Heitman J; Perfect J R
Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein.
Infection and immunity 1999;67(4):1812-20.
-
1999: Hemenway C S; Heitman J
Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.
Molecular & general genetics : MGG 1999;261(2):388-401.
-
1999: Dolinski K J; Heitman J
Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
Genetics 1999;151(3):935-44.
-
1999: Scholz C; Maier P; Dolinski K; Heitman J; Schmid F X
R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays.
FEBS letters 1999;443(3):367-9.
-
1999: Heitman J; Casadevall A; Lodge J K; Perfect J R
The Cryptococcus neoformans genome sequencing project.
Mycopathologia 1999;148(1):1-7.
-
1998: Lorenz M C; Heitman J
Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains.
Genetics 1998;150(4):1443-57.
-
1998: Dolinski K J; Cardenas M E; Heitman J
CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.
Molecular and cellular biology 1998;18(12):7344-52.
-
1998: Cardenas M E; Sanfridson A; Cutler N S; Heitman J
Signal-transduction cascades as targets for therapeutic intervention by natural products.
Trends in biotechnology 1998;16(10):427-33.
-
1998: Alspaugh J A; Perfect J R; Heitman J
Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.
Fungal genetics and biology : FG & B 1998;25(1):1-14.
-
1998: Lorenz M C; Heitman J
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
The EMBO journal 1998;17(5):1236-47.
-
1998: Ivanenko T; Heitman J; Kiss A
Mutational analysis of the function of Met137 and Ile197, two amino acids implicated in sequence-specific DNA recognition by the EcoRI endonuclease.
Biological chemistry 1998;379(4-5):459-65.
-
1998: Bassing C H; Shou W; Muir S; Heitman J; Matzuk M M; Wang X F
FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(3):223-8.
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1997: Muir R S; Flores H; Zinder N D; Model P; Soberon X; Heitman J
Temperature-sensitive mutants of the EcoRI endonuclease.
Journal of molecular biology 1997;274(5):722-37.
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1997: Alspaugh J A; Perfect J R; Heitman J
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
Genes & development 1997;11(23):3206-17.
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1997: Lorenz M C; Heitman J
Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
The EMBO journal 1997;16(23):7008-18.
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1997: Dolinski K; Muir S; Cardenas M; Heitman J
All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13093-8.
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1997: Dolinski K; Scholz C; Muir R S; Rospert S; Schmid F X; Cardenas M E; Heitman J
Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae.
Molecular biology of the cell 1997;8(11):2267-80.
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1997: Cutler N S; Heitman J; Cardenas M E
STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae.
The Journal of biological chemistry 1997;272(44):27671-7.
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1997: Alarcón C M; Heitman J
FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.
Molecular and cellular biology 1997;17(10):5968-75.
-
1997: Scholz C; Schindler T; Dolinski K; Heitman J; Schmid F X
Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate.
FEBS letters 1997;414(1):69-73.
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1997: Odom A; Muir S; Lim E; Toffaletti D L; Perfect J; Heitman J
Calcineurin is required for virulence of Cryptococcus neoformans.
The EMBO journal 1997;16(10):2576-89.
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1997: Odom A; Del Poeta M; Perfect J; Heitman J
The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
Antimicrobial agents and chemotherapy 1997;41(1):156-61.
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1996: Koller A; Heitman J; Hall M N
Regional bivalent-univalent pairing versus trivalent pairing of a trisomic chromosome in Saccharomyces cerevisiae.
Genetics 1996;144(3):957-66.
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1996: Zhu D; Cardenas M E; Heitman J
Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
Molecular pharmacology 1996;50(3):506-11.
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1996: Hemenway C S; Heitman J
Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.
The Journal of biological chemistry 1996;271(31):18527-34.
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1996: Ruetz S; Brault M; Kast C; Hemenway C; Heitman J; Grant C E; Cole S P; Deeley R G; Gros P
Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1996;271(8):4154-60.
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1996: Alarcon C M; Cardenas M E; Heitman J
Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.
Genes & development 1996;10(3):279-88.
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1995: Cardenas M E; Zhu D; Heitman J
Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
Current opinion in nephrology and hypertension 1995;4(6):472-7.
-
1995: Hemenway C S; Dolinski K; Cardenas M E; Hiller M A; Jones E W; Heitman J
vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.
Genetics 1995;141(3):833-44.
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1995: Lorenz M C; Heitman J
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
The Journal of biological chemistry 1995;270(46):27531-7.
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1995: Zhu D; Cardenas M E; Heitman J
Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(42):24831-8.
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1995: Cardenas M E; Lim E; Heitman J
Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(36):20997-1002.
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1995: Cardenas M E; Muir R S; Breuder T; Heitman J
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
The EMBO journal 1995;14(12):2772-83.
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1995: Lorenz M C; Muir R S; Lim E; McElver J; Weber S C; Heitman J
Gene disruption with PCR products in Saccharomyces cerevisiae.
Gene 1995;158(1):113-7.
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1995: Flores H; Osuna J; Heitman J; Soberón X
Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants.
Gene 1995;157(1-2):295-301.
-
1995: Cardenas M E; Heitman J
Role of calcium in T-lymphocyte activation.
Advances in second messenger and phosphoprotein research 1995;30():281-98.
-
1994: Cardenas M E; Hemenway C; Muir R S; Ye R; Fiorentino D; Heitman J
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
The EMBO journal 1994;13(24):5944-57.
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1994: Heitman J; Cardenas M E; Breuder T; Hemenway C; Muir R S; Lim E; Goetz L; Zhu D; Lorenz M; Dolinski K
Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
Transplantation proceedings 1994;26(5):2833-4.
-
1994: Breuder T; Hemenway C S; Movva N R; Cardenas M E; Heitman J
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5372-6.
-
1993: Hemenway C; Heitman J
Proline isomerases in microorganisms and small eukaryotes.
Annals of the New York Academy of Sciences 1993;696():38-46.
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1993: Heitman J; Koller A; Kunz J; Henriquez R; Schmidt A; Movva N R; Hall M N
The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.
Molecular and cellular biology 1993;13(8):5010-9.
-
1993: Blot M; Heitman J; Arber W
Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes.
Molecular microbiology 1993;8(6):1017-24.
-
1992: Heitman J
How the EcoRI endonuclease recognizes and cleaves DNA.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(7):445-54.
-
1992: Heitman J; Movva N R; Hall M N
Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression.
The New biologist 1992;4(5):448-60.
-
1991: Heitman J; Movva N R; Hall M N
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
Science (New York, N.Y.) 1991;253(5022):905-9.
-
1991: Heitman J; Model P
SOS induction as an in vivo assay of enzyme-DNA interactions.
Gene 1991;103(1):1-9.
-
1991: Heitman J; Movva N R; Hiestand P C; Hall M N
FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1948-52.
-
1990: Heitman J; Model P
Mutants of the EcoRI endonuclease with promiscuous substrate specificity implicate residues involved in substrate recognition.
The EMBO journal 1990;9(10):3369-78.
-
1990: Heitman J; Model P
Substrate recognition by the EcoRI endonuclease.
Proteins 1990;7(2):185-97.
-
1989: Heitman J; Fulford W; Model P
Phage Trojan horses: a conditional expression system for lethal genes.
Gene 1989;85(1):193-7.
-
1989: Heitman J; Treisman J; Davis N G; Russel M
Cassettes of the f1 intergenic region.
Nucleic acids research 1989;17(11):4413.
-
1989: Heitman J; Zinder N D; Model P
Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2281-5.
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