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Sheila Heitner

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Yao-Qi Huang; Harald Sauthoff; Pablo Herscovici; Teona Pipiya; Jin Cheng; Sheila Heitner; Oskar Szentirmai; Bob Carter; John G Hay
Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury.
Harald Sauthoff; Teona Pipiya; Shu Chen; Sheila Heitner; Jin Cheng; Yao-Qi Huang; William N Rom; John G Hay
Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53.
Teona Pipiya; Harald Sauthoff; Yao-Qi Huang; B Chang; Jin Cheng; Sheila Heitner; Shu Chen; William N Rom; John G Hay
Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression.

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2008: Yao-Qi Huang; Harald Sauthoff; Pablo Herscovici; Teona Pipiya; Jin Cheng; Sheila Heitner; Oskar Szentirmai; Bob Carter; John G Hay
Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury.
Critical care medicine 2008;36(1):262-7.
2006: Harald Sauthoff; Teona Pipiya; Shu Chen; Sheila Heitner; Jin Cheng; Yao-Qi Huang; William N Rom; John G Hay
Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53.
Cancer gene therapy 2006;13(7):686-95.
2005: Teona Pipiya; Harald Sauthoff; Yao-Qi Huang; B Chang; Jin Cheng; Sheila Heitner; Shu Chen; William N Rom; John G Hay
Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression.
Gene therapy 2005;12(11):911-7.
2004: Harald Sauthoff; Teona Pipiya; Sheila Heitner; Shu Chen; Bertram Bleck; Joan Reibman; William Chang; Robert Norman; William N Rom; John G Hay
Impact of E1a modifications on tumor-selective adenoviral replication and toxicity.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(4):749-57.
2003: Harald Sauthoff; Jing Hu; Cielo Maca; Michael Goldman; Sheila Heitner; Herman Yee; Teona Pipiya; William N Rom; John G Hay
Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points.
Human gene therapy 2003;14(5):425-33.
2002: Harald Sauthoff; Teona Pipiya; Sheila Heitner; Shu Chen; Robert Norman; William N Rom; John G Hay
Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death protein.
Human gene therapy 2002;13(15):1859-71.
2001: D Harrison; Harald Sauthoff; Sheila Heitner; Jaishree Jagirdar; William N Rom; John G Hay
Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effect.
Human gene therapy 2001;12(10):1323-32.
2000: Harald Sauthoff; Sheila Heitner; William N Rom; John G Hay
Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector.
Human gene therapy 2000;11(3):379-88.
1999: John G Hay; N Shapiro; Harald Sauthoff; Sheila Heitner; W Phupakdi; William N Rom
Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: the importance of the adenoviral E1b-55kD gene.
Human gene therapy 1999;10(4):579-90.