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Siegfried Hekimi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
10
Branicky, Robyn
9
Bénard, Claire
7
Lakowski, B
7
Barnes, Tom
5
Hihi, Abdelmadjid
4
Burgess, Jason
4
Labbé, Jean-Claude
4
Shoubridge, Eric
3
Bussière, F
3
Ewbank, JJ
3
Jiang, Ning
3
Kita, Kiyoshi
3
Meng, Yan
3
Miyadera, Hiroko
3
Rokeach, Luis

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Publications

TOP 3
Lapointe Jérôme; Stepanyan Zaruhi; Bigras Eve; Hekimi Siegfried
Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.
Van Raamsdonk Jeremy M; Hekimi Siegfried
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
Wang Ying; Branicky Robyn; Stepanyan Zaruhi; Carroll Melissa; Guimond Marie-Pierre; Hihi Abdelmadjid; Hayes Steve; McBride Kevin; Hekimi Siegfried
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

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All Publications

2009: Lapointe Jérôme; Stepanyan Zaruhi; Bigras Eve; Hekimi Siegfried
Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.
The Journal of biological chemistry 2009;284(30):20364-74.
2009: Van Raamsdonk Jeremy M; Hekimi Siegfried
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
PLoS genetics 2009;5(2):e1000361.
2009: Wang Ying; Branicky Robyn; Stepanyan Zaruhi; Carroll Melissa; Guimond Marie-Pierre; Hihi Abdelmadjid; Hayes Steve; McBride Kevin; Hekimi Siegfried
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
The Journal of biological chemistry 2009;284(1):314-23.
2009: Hughes Bryan G; Hekimi Siegfried
Mclk1+/- mice are not resistant to the development of atherosclerosis.
Lipids in health and disease 2009;8():16.
2008: Lapointe Jérôme; Hekimi Siegfried
Early mitochondrial dysfunction in long-lived Mclk1+/- mice.
The Journal of biological chemistry 2008;283(38):26217-27.
2008: Hihi Abdelmadjid K; Beauchamp Marie-Claude; Branicky Robyn; Desjardins Annick; Casanova Isabel; Guimond Marie-Pierre; Carroll Melissa; Ethier Melanie; Kianicka Irenej; McBride Kevin; Hekimi Siegfried
Evolutionary conservation of drug action on lipoprotein metabolism-related targets.
Journal of lipid research 2008;49(1):74-83.
2007: Yang Wen; Li Jingjing; Hekimi Siegfried
A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.
Genetics 2007;177(4):2063-74.
2006: Branicky Robyn; Hekimi Siegfried
What keeps C. elegans regular: the genetics of defecation.
Trends in genetics : TIG 2006;22(10):571-9.
2006: Stepanyan Zaruhi; Hughes Bryan; Cliche Dominic O; Camp Darius; Hekimi Siegfried
Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging.
Experimental gerontology 2006;41(10):940-51.
2006: Hekimi Siegfried
How genetic analysis tests theories of animal aging.
Nature genetics 2006;38(9):985-91.
2006: Seitan Vlad C; Banks Peter; Laval Steve; Majid Nazia A; Dorsett Dale; Rana Amer; Smith Jim; Bateman Alex; Krpic Sanja; Hostert Arnd; Rollins Robert A; Erdjument-Bromage Hediye; Tempst Paul; Benard Claire Y; Hekimi Siegfried; Newbury Sarah F; Strachan Tom
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
PLoS biology 2006;4(8):e242.
2006: Branicky Robyn; Nguyen Phuong Anh Thi; Hekimi Siegfried
Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.
Molecular and cellular biology 2006;26(10):3976-85.
2005: Branicky Robyn; Hekimi Siegfried
Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans.
Development (Cambridge, England) 2005;132(22):4999-5009.
2005: Liu Xingxing; Jiang Ning; Hughes Bryan; Bigras Eve; Shoubridge Eric; Hekimi Siegfried
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.
Genes & development 2005;19(20):2424-34.
2004: Bénard Claire Y; Kébir Hania; Takagi Shin; Hekimi Siegfried
mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans.
Development (Cambridge, England) 2004;131(23):5947-58.
2004: de Jong Liesbeth; Meng Yan; Dent Joseph; Hekimi Siegfried
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans.
Genetics 2004;168(2):845-54.
2003: Shibata Yukimasa; Branicky Robyn; Landaverde Irene Oviedo; Hekimi Siegfried
Redox regulation of germline and vulval development in Caenorhabditis elegans.
Science (New York, N.Y.) 2003;302(5651):1779-82.
2003: Burgess Jason; Hihi Abdelmadjid K; Benard Claire Y; Branicky Robyn; Hekimi Siegfried
Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans.
The Journal of biological chemistry 2003;278(49):49555-62.
2003: Hihi Abdelmadjid K; Kebir Hania; Hekimi Siegfried
Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.
The Journal of biological chemistry 2003;278(42):41013-8.
2003: Jiang Ning; Bénard Claire Y; Kébir Hania; Shoubridge Eric A; Hekimi Siegfried
Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation.
The Journal of biological chemistry 2003;278(24):21678-84.
2003: Hekimi Siegfried; Guarente Leonard
Genetics and the specificity of the aging process.
Science (New York, N.Y.) 2003;299(5611):1351-4.
2002: Bénard Claire; Hekimi Siegfried
Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans.
Mechanisms of ageing and development 2002;123(8):869-80.
2002: Miyadera Hiroko; Kano Kenji; Miyoshi Hideto; Ishii Naoaki; Hekimi Siegfried; Kita Kiyoshi
Quinones in long-lived clk-1 mutants of Caenorhabditis elegans.
FEBS letters 2002;512(1-3):33-7.
2002: Hihi Abdelmadjid K; Gao Yuan; Hekimi Siegfried
Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites.
The Journal of biological chemistry 2002;277(3):2202-6.
2001: Hekimi S; Burgess J; Bussière F; Meng Y; Bénard C
Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity.
Trends in genetics : TIG 2001;17(12):712-8.
2001: Levavasseur F; Miyadera H; Sirois J; Tremblay M L; Kita K; Shoubridge E; Hekimi S
Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration.
The Journal of biological chemistry 2001;276(49):46160-4.
2001: Branicky R; Shibata Y; Feng J; Hekimi S
Phenotypic and suppressor analysis of defecation in clk-1 mutants reveals that reaction to changes in temperature is an active process in Caenorhabditis elegans.
Genetics 2001;159(3):997-1006.
2001: Feng J; Bussière F; Hekimi S
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.
Developmental cell 2001;1(5):633-44.
2001: Bénard C; McCright B; Zhang Y; Felkai S; Lakowski B; Hekimi S
The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length.
Development (Cambridge, England) 2001;128(20):4045-55.
2001: Lemieux J; Lakowski B; Webb A; Meng Y; Ubach A; Bussière F; Barnes T; Hekimi S
Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria.
Genetics 2001;159(1):147-57.
2001: Jiang N; Levavasseur F; McCright B; Shoubridge E A; Hekimi S
Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential.
The Journal of biological chemistry 2001;276(31):29218-25.
2001: Hekimi S; Bénard C; Branicky R; Burgess J; Hihi A K; Rea S
Why only time will tell.
Mechanisms of ageing and development 2001;122(7):571-94.
2001: Miyadera H; Amino H; Hiraishi A; Taka H; Murayama K; Miyoshi H; Sakamoto K; Ishii N; Hekimi S; Kita K
Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.
The Journal of biological chemistry 2001;276(11):7713-6.
2000: Labbé J C; Burgess J; Rokeach L A; Hekimi S
ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13233-8.
2000: Branicky R; Bénard C; Hekimi S
clk-1, mitochondria, and physiological rates.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(1):48-56.
1999: Whitfield C W; Bénard C; Barnes T; Hekimi S; Kim S K
Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.
Molecular biology of the cell 1999;10(6):2087-100.
1999: Felkai S; Ewbank J J; Lemieux J; Labbé J C; Brown G G; Hekimi S
CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.
The EMBO journal 1999;18(7):1783-92.
1999: Labbé J C; Hekimi S; Rokeach L A
The levels of the RoRNP-associated Y RNA are dependent upon the presence of ROP-1, the Caenorhabditis elegans Ro60 protein.
Genetics 1999;151(1):143-50.
1999: Labbé J C; Hekimi S; Rokeach L A
Assessing the function of the Ro ribonucleoprotein complex using Caenorhabditis elegans as a biological tool.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1999;77(4):349-54.
1998: Lakowski B; Hekimi S
The genetics of caloric restriction in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13091-6.
1998: Phelan P; Bacon J P; Davies J A; Stebbings L A; Todman M G; Avery L; Baines R A; Barnes T M; Ford C; Hekimi S; Lee R; Shaw J E; Starich T A; Curtin K D; Sun Y A; Wyman R J
Innexins: a family of invertebrate gap-junction proteins.
Trends in genetics : TIG 1998;14(9):348-9.
1998: Hekimi S; Lakowski B; Barnes T M; Ewbank J J
Molecular genetics of life span in C. elegans: how much does it teach us?
Trends in genetics : TIG 1998;14(1):14-20.
1997: Barnes T M; Hekimi S
The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells.
Journal of neurochemistry 1997;69(6):2251-60.
1997: Takagi S; Bénard C; Pak J; Livingstone D; Hekimi S
Cellular and axonal migrations are misguided along both body axes in the maternal-effect mau-2 mutants of Caenorhabditis elegans.
Development (Cambridge, England) 1997;124(24):5115-26.
1997: Ogura K; Shirakawa M; Barnes T M; Hekimi S; Ohshima Y
The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51.
Genes & development 1997;11(14):1801-11.
1997: Ewbank J J; Barnes T M; Lakowski B; Lussier M; Bussey H; Hekimi S
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
Science (New York, N.Y.) 1997;275(5302):980-3.
1996: Barnes T M; Jin Y; Horvitz H R; Ruvkun G; Hekimi S
The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.
Journal of neurochemistry 1996;67(1):46-57.
1996: Lakowski B; Hekimi S
Determination of life-span in Caenorhabditis elegans by four clock genes.
Science (New York, N.Y.) 1996;272(5264):1010-3.
1995: Hekimi S; Boutis P; Lakowski B
Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans.
Genetics 1995;141(4):1351-64.
1995: Barnes T M; Kohara Y; Coulson A; Hekimi S
Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans.
Genetics 1995;141(1):159-79.
1995: Wong A; Boutis P; Hekimi S
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.
Genetics 1995;139(3):1247-59.
1993: Hekimi S; Kershaw D
Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4254-71.

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