Carl-Henrik Heldin

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Moustakas Aristidis; Heldin Carl-Henrik
The regulation of TGFbeta signal transduction.
Paulsson Janna; Sjöblom Tobias; Micke Patrick; Pontén Fredrik; Landberg Göran; Heldin Carl-Henrik; Bergh Jonas; Brennan Donal J; Jirström Karin; Ostman Arne
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
Hellberg Carina; Schmees Christian; Karlsson Susann; Ahgren Aive; Heldin Carl-Henrik
Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.

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All Publications

2009: Moustakas Aristidis; Heldin Carl-Henrik
The regulation of TGFbeta signal transduction.
Development (Cambridge, England) 2009;136(22):3699-714.
2009: Paulsson Janna; Sjöblom Tobias; Micke Patrick; Pontén Fredrik; Landberg Göran; Heldin Carl-Henrik; Bergh Jonas; Brennan Donal J; Jirström Karin; Ostman Arne
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
The American journal of pathology 2009;175(1):334-41.
2009: Hellberg Carina; Schmees Christian; Karlsson Susann; Ahgren Aive; Heldin Carl-Henrik
Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.
Molecular biology of the cell 2009;20(12):2856-63.
2009: Heldin Carl-Henrik; Landström Maréne; Moustakas Aristidis
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.
Current opinion in cell biology 2009;21(2):166-76.
2009: Thakur Noopur; Sorrentino Alessandro; Heldin Carl-Henrik; Landström Maréne
TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells.
Future oncology (London, England) 2009;5(1):1-3.
2009: Jurek Aleksandra; Amagasaki Kenichi; Gembarska Agnieszka; Heldin Carl-Henrik; Lennartsson Johan
Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation.
The Journal of biological chemistry 2009;284(7):4626-34.
2009: Huminiecki Lukasz; Goldovsky Leon; Freilich Shiri; Moustakas Aristidis; Ouzounis Christos; Heldin Carl-Henrik
Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom.
BMC evolutionary biology 2009;9():28.
2008: Krampert Monika; Heldin Carl-Henrik; Heuchel Rainer L
A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.
Laboratory investigation; a journal of technical methods and pathology 2008;88(11):1204-14.
2008: Ruusala Aino; Pawson Tony; Heldin Carl-Henrik; Aspenström Pontus
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
The Journal of biological chemistry 2008;283(44):30034-44.
2008: Sorrentino Alessandro; Thakur Noopur; Grimsby Susanne; Marcusson Anders; von Bulow Verena; Schuster Norbert; Zhang Shouting; Heldin Carl-Henrik; Landström Maréne
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
Nature cell biology 2008;10(10):1199-207.
2008: Kowanetz Marcin; Lönn Peter; Vanlandewijck Michael; Kowanetz Katarzyna; Heldin Carl-Henrik; Moustakas Aristidis
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.
The Journal of cell biology 2008;182(4):655-62.
2008: Rosengren Pielberg Gerli; Golovko Anna; Sundström Elisabeth; Curik Ino; Lennartsson Johan; Seltenhammer Monika H; Druml Thomas; Binns Matthew; Fitzsimmons Carolyn; Lindgren Gabriella; Sandberg Kaj; Baumung Roswitha; Vetterlein Monika; Strömberg Sara; Grabherr Manfred; Wade Claire; Lindblad-Toh Kerstin; Pontén Fredrik; Heldin Carl-Henrik; Sölkner Johann; Andersson Leif
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse.
Nature genetics 2008;40(8):1004-9.
2008: Moustakas Aristidis; Heldin Carl-Henrik
Dynamic control of TGF-beta signaling and its links to the cytoskeleton.
FEBS letters 2008;582(14):2051-65.
2008: Heldin Carl-Henrik
The European Research Council--a new opportunity for European science.
Nature reviews. Molecular cell biology 2008;9(5):417-20.
2008: Li Yang; Zhang Fan; Nagai Nobuo; Tang Zhongshu; Zhang Shuihua; Scotney Pierre; Lennartsson Johan; Zhu Chaoyong; Qu Yi; Fang Changge; Hua Jianyuan; Matsuo Osamu; Fong Guo-Hua; Ding Hao; Cao Yihai; Becker Kevin G; Nash Andrew; Heldin Carl-Henrik; Li Xuri
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.
The Journal of clinical investigation 2008;118(3):913-23.
2007: Hasumi Yoko; Klosowska-Wardega Agnieszka; Furuhashi Masao; Ostman Arne; Heldin Carl-Henrik; Hellberg Carina
Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.
International journal of cancer. Journal international du cancer 2007;121(12):2606-14.
2007: Ekman Simon; Bergqvist Michael; Heldin Carl-Henrik; Lennartsson Johan
Activation of growth factor receptors in esophageal cancer--implications for therapy.
The oncologist 2007;12(10):1165-77.
2007: Moustakas Aristidis; Heldin Carl-Henrik
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression.
Cancer science 2007;98(10):1512-20.
2007: Kallin Anders; Johannessen Lene E; Cani Patrice D; Marbehant Catherine Y; Essaghir Ahmed; Foufelle Fabienne; Ferré Pascal; Heldin Carl-Henrik; Delzenne Nathalie M; Demoulin Jean-Baptiste
SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.
Journal of lipid research 2007;48(7):1628-36.
2007: Valcourt Ulrich; Thuault Sylvie; Pardali Katerina; Heldin Carl-Henrik; Moustakas Aristidis
Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
Molecular oncology 2007;1(1):55-71.
2007: Li Lingli; Asteriou Trias; Bernert Berit; Heldin Carl-Henrik; Heldin Paraskevi
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.
The Biochemical journal 2007;404(2):327-36.
2007: Micke Patrick; Kappert Kai; Ohshima Mitsuhiro; Sundquist Christina; Scheidl Stefan; Lindahl Per; Heldin Carl-Henrik; Botling Johan; Ponten Fredrik; Ostman Arne
In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma.
The Journal of investigative dermatology 2007;127(6):1516-23.
2007: Niimi Hideki; Pardali Katerina; Vanlandewijck Michael; Heldin Carl-Henrik; Moustakas Aristidis
Notch signaling is necessary for epithelial growth arrest by TGF-beta.
The Journal of cell biology 2007;176(5):695-707.
2007: Suzuki Shioto; Heldin Carl-Henrik; Heuchel Rainer Lothar
Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.
BMC cancer 2007;7():224.
2007: Looman Camilla; Sun Tong; Yu Yang; Zieba Agata; Ahgren Aive; Feinstein Ricardo; Forsberg Henrik; Hellberg Carina; Heldin Carl-Henrik; Zhang Xiao-Qun; Forsberg-Nilsson Karin; Khoo Nelson; Fundele Reinald; Heuchel Rainer
An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.
The International journal of developmental biology 2007;51(5):361-70.
2007: Ostman Arne; Heldin Carl-Henrik
PDGF receptors as targets in tumor treatment.
Advances in cancer research 2007;97():247-74.
2006: Zhang Shouting; Ekman Maria; Thakur Noopur; Bu Shizhong; Davoodpour Padideh; Grimsby Susanne; Tagami Seicchi; Heldin Carl-Henrik; Landström Marene
TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner.
Cell cycle (Georgetown, Tex.) 2006;5(23):2787-95.
2006: Lennartsson Johan; Wardega Piotr; Engström Ulla; Hellman Ulf; Heldin Carl-Henrik
Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.
The Journal of biological chemistry 2006;281(51):39152-8.
2006: Simonsson Maria; Kanduri Meena; Grönroos Eva; Heldin Carl-Henrik; Ericsson Johan
The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.
The Journal of biological chemistry 2006;281(52):39870-80.
2006: Kappert Kai; Leppänen Olli; Paulsson Janna; Furuhashi Masao; Carlsson Mari-Anne; Heldin Carl-Henrik; Fätkenheuer Gerd; Rosenkranz Stephan; Ostman Arne
Highly active antiretroviral therapy attenuates re-endothelialization and alters neointima formation in the rat carotid artery after balloon injury.
Journal of acquired immune deficiency syndromes (1999) 2006;43(4):383-92.
2006: Karlsson Susann; Kowanetz Katarzyna; Sandin Asa; Persson Camilla; Ostman Arne; Heldin Carl-Henrik; Hellberg Carina
Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor.
Molecular biology of the cell 2006;17(11):4846-55.
2006: Demoulin Jean-Baptiste; Enarsson Mia; Larsson Jimmy; Essaghir Ahmed; Heldin Carl-Henrik; Forsberg-Nilsson Karin
The gene expression profile of PDGF-treated neural stem cells corresponds to partially differentiated neurons and glia.
Growth factors (Chur, Switzerland) 2006;24(3):184-96.
2006: Li Lingli; Heldin Carl-Henrik; Heldin Paraskevi
Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44.
The Journal of biological chemistry 2006;281(36):26512-9.
2006: Amagasaki Kenichi; Kaneto Hideaki; Heldin Carl-Henrik; Lennartsson Johan
c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts.
The Journal of biological chemistry 2006;281(31):22173-9.
2006: Thuault Sylvie; Valcourt Ulrich; Petersen Maj; Manfioletti Guidalberto; Heldin Carl-Henrik; Moustakas Aristidis
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.
The Journal of cell biology 2006;174(2):175-83.
2006: Heldin Carl-Henrik; Moustakas Aristidis
A new twist in Smad signaling.
Developmental cell 2006;10(6):685-6.
2006: Li Ronggui; Rosendahl Alexander; Brodin Greger; Cheng Alec M; Ahgren Aive; Sundquist Christina; Kulkarni Sarang; Pawson Tony; Heldin Carl-Henrik; Heuchel Rainer L
Deletion of exon I of SMAD7 in mice results in altered B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6777-84.
2006: Kurisaki Akira; Kurisaki Keiko; Kowanetz Marcin; Sugino Hiromu; Yoneda Yoshihiro; Heldin Carl-Henrik; Moustakas Aristidis
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Molecular and cellular biology 2006;26(4):1318-32.
2006: Valdimarsdottir Gudrun; Goumans Marie-José; Itoh Fumiko; Itoh Susumu; Heldin Carl-Henrik; ten Dijke Peter
Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells.
BMC cell biology 2006;7():16.
2005: Stasyk Taras; Dubrovska Anna; Lomnytska Marta; Yakymovych Ihor; Wernstedt Christer; Heldin Carl-Henrik; Hellman Ulf; Souchelnytskyi Serhiy
Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription.
Molecular biology of the cell 2005;16(10):4765-80.
2005: Moustakas Aristidis; Heldin Carl-Henrik
Non-Smad TGF-beta signals.
Journal of cell science 2005;118(Pt 16):3573-84.
2005: Pardali Katerina; Kowanetz Marcin; Heldin Carl-Henrik; Moustakas Aristidis
Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1).
Journal of cellular physiology 2005;204(1):260-72.
2005: Simonsson Maria; Heldin Carl-Henrik; Ericsson Johan; Grönroos Eva
The balance between acetylation and deacetylation controls Smad7 stability.
The Journal of biological chemistry 2005;280(23):21797-803.
2005: Morén Anita; Imamura Takeshi; Miyazono Kohei; Heldin Carl-Henrik; Moustakas Aristidis
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.
The Journal of biological chemistry 2005;280(23):22115-23.
2005: Valcourt Ulrich; Kowanetz Marcin; Niimi Hideki; Heldin Carl-Henrik; Moustakas Aristidis
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.
Molecular biology of the cell 2005;16(4):1987-2002.
2005: Dubrovska Anna; Kanamoto Takashi; Lomnytska Marta; Heldin Carl-Henrik; Volodko Natalya; Souchelnytskyi Serhiy
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
Oncogene 2005;24(14):2289-97.
2005: Edlund Sofia; Lee So Young; Grimsby Susanne; Zhang Shouthing; Aspenström Pontus; Heldin Carl-Henrik; Landström Maréne
Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis.
Molecular and cellular biology 2005;25(4):1475-88.
2005: Siegbahn Agneta; Johnell Matilda; Sorensen Brit B; Petersen Lars C; Heldin Carl-Henrik
Regulation of chemotaxis by the cytoplasmic domain of tissue factor.
Thrombosis and haemostasis 2005;93(1):27-34.
2005: Li Xuri; Tjwa Marc; Moons Lieve; Fons Pierre; Noel Agnes; Ny Annelii; Zhou Jian Min; Lennartsson Johan; Li Hong; Luttun Aernout; Pontén Annica; Devy Laetitia; Bouché Ann; Oh Hideyasu; Manderveld Ann; Blacher Silvia; Communi David; Savi Pierre; Bono Françoise; Dewerchin Mieke; Foidart Jean-Michel; Autiero Monica; Herbert Jean-Marc; Collen D; Heldin Carl-Henrik; Eriksson Ulf; Carmeliet Peter
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
The Journal of clinical investigation 2005;115(1):118-27.
2004: Heldin Carl-Henrik; Rubin Kristofer; Pietras Kristian; Ostman Arne
High interstitial fluid pressure - an obstacle in cancer therapy.
Nature reviews. Cancer 2004;4(10):806-13.
2004: Chiara Federica; Goumans Marie-José; Forsberg Henrik; Ahgrén Aive; Rasola Andrea; Aspenström Pontus; Wernstedt Christer; Hellberg Carina; Heldin Carl-Henrik; Heuchel Rainer
A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.
The Journal of biological chemistry 2004;279(41):42516-27.
2004: Demoulin Jean-Baptiste; Ericsson Johan; Kallin Anders; Rorsman Charlotte; Rönnstrand Lars; Heldin Carl-Henrik
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.
The Journal of biological chemistry 2004;279(34):35392-402.
2004: Yakymovych Ihor; Heldin Carl-Henrik; Souchelnytskyi Serhiy
Smad2 phosphorylation by type I receptor: contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity.
The Journal of biological chemistry 2004;279(34):35781-7.
2004: Heldin Carl-Henrik
Platelet-derived growth factor--an introduction.
Cytokine & growth factor reviews 2004;15(4):195-6.
2004: Kowanetz Katarzyna; Crosetto Nicola; Haglund Kaisa; Schmidt Mirko H H; Heldin Carl-Henrik; Dikic Ivan
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
The Journal of biological chemistry 2004;279(31):32786-95.
2004: Kowanetz Marcin; Valcourt Ulrich; Bergström Rosita; Heldin Carl-Henrik; Moustakas Aristidis
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.
Molecular and cellular biology 2004;24(10):4241-54.
2004: Chiara Federica; Bishayee Subal; Heldin Carl-Henrik; Demoulin Jean-Baptiste
Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail.
The Journal of biological chemistry 2004;279(19):19732-8.
2004: Furuhashi Masao; Sjöblom Tobias; Abramsson Alexandra; Ellingsen Jens; Micke Patrick; Li Hong; Bergsten-Folestad Erika; Eriksson Ulf; Heuchel Rainer; Betsholtz Christer; Heldin Carl-Henrik; Ostman Arne
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
Cancer research 2004;64(8):2725-33.
2004: Edlund Sofia; Landström Maréne; Heldin Carl-Henrik; Aspenström Pontus
Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42.
Journal of cell science 2004;117(Pt 9):1835-47.
2004: Kallin Anders; Demoulin Jean-Baptiste; Nishida Keigo; Hirano Toshio; Rönnstrand Lars; Heldin Carl-Henrik
Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.
The Journal of biological chemistry 2004;279(17):17897-904.
2004: Persson Camilla; Sävenhed Catrine; Bourdeau Annie; Tremblay Michel L; Markova Boyka; Böhmer Frank D; Haj Fawaz G; Neel Benjamin G; Elson Ari; Heldin Carl-Henrik; Rönnstrand Lars; Ostman Arne; Hellberg Carina
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Molecular and cellular biology 2004;24(5):2190-201.
2004: Leppänen Olli; Rutanen Juha; Hiltunen Mikko O; Rissanen Tuomas T; Turunen Mikko P; Sjöblom Tobias; Brüggen Josef; Bäckström Gudrun; Carlsson Marianne; Buchdunger Elisabeth; Bergqvist David; Alitalo Kari; Heldin Carl-Henrik; Ostman Arne; Ylä-Herttuala Seppo
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Circulation 2004;109(9):1140-6.
2004: Persson Camilla; Sjöblom Tobias; Groen Arnoud; Kappert Kai; Engström Ulla; Hellman Ulf; Heldin Carl-Henrik; den Hertog Jeroen; Ostman Arne
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1886-91.
2004: Sjöblom T; Yakymovych I; Heldin C-H; Ostman A; Souchelnytskyi S
Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice.
European journal of cancer (Oxford, England : 1990) 2004;40(2):267-74.
2004: Heldin Carl-Henrik
Development and possible clinical use of antagonists for PDGF and TGF-beta.
Upsala journal of medical sciences 2004;109(3):165-78.
2003: Moustakas Aristidis; Heldin Carl-Henrik
Ecsit-ement on the crossroads of Toll and BMP signal transduction.
Genes & development 2003;17(23):2855-9.
2003: Demoulin Jean-Baptiste; Seo Jeong Kon; Ekman Simon; Grapengiesser Eva; Hellman Ulf; Rönnstrand Lars; Heldin Carl-Henrik
Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF.
The Biochemical journal 2003;376(Pt 2):505-10.
2003: Moustakas Aristidis; Heldin Carl-Henrik
The nuts and bolts of IRF structure.
Nature structural biology 2003;10(11):874-6.
2003: Pietras Kristian; Stumm Michael; Hubert Martine; Buchdunger Elisabeth; Rubin Kristofer; Heldin Carl-Henrik; McSheehy Paul; Wartmann Markus; Ostman Arne
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3779-87.
2003: Morén Anita; Hellman Ulf; Inada Yuri; Imamura Takeshi; Heldin Carl-Henrik; Moustakas Aristidis
Differential ubiquitination defines the functional status of the tumor suppressor Smad4.
The Journal of biological chemistry 2003;278(35):33571-82.
2003: Kurisaki Keiko; Kurisaki Akira; Valcourt Ulrich; Terentiev Alexei A; Pardali Katerina; Ten Dijke Peter; Heldin Carl-Henrik; Ericsson Johan; Moustakas Aristidis
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.
Molecular and cellular biology 2003;23(13):4494-510.
2003: Pietras Kristian; Sjöblom Tobias; Rubin Kristofer; Heldin Carl-Henrik; Ostman Arne
PDGF receptors as cancer drug targets.
Cancer cell 2003;3(5):439-43.
2003: Gizatullina Zemfira Z; Grapengiesser Eva; Shabalina Irina G; Nedergaard Jan; Heldin Carl-Henrik; Aspenström Pontus
Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells.
Biochemical and biophysical research communications 2003;304(4):643-9.
2003: Edlund Sofia; Bu Shizhong; Schuster Norbert; Aspenström Pontus; Heuchel Rainer; Heldin Nils-Erik; ten Dijke Peter; Heldin Carl-Henrik; Landström Maréne
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
Molecular biology of the cell 2003;14(2):529-44.
2003: Itoh Susumu; Thorikay Midory; Kowanetz Marcin; Moustakas Aristidis; Itoh Fumiko; Heldin Carl-Henrik; ten Dijke Peter
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.
The Journal of biological chemistry 2003;278(6):3751-61.
2002: Pietras Kristian; Rubin Kristofer; Sjöblom Tobias; Buchdunger Elisabeth; Sjöquist Mats; Heldin Carl-Henrik; Ostman Arne
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Cancer research 2002;62(19):5476-84.
2002: Grönroos Eva; Hellman Ulf; Heldin Carl-Henrik; Ericsson Johan
Control of Smad7 stability by competition between acetylation and ubiquitination.
Molecular cell 2002;10(3):483-93.
2002: Yakymovych Ihor; Engström Ulla; Grimsby Susanne; Heldin Carl-Henrik; Souchelnytskyi Serhiy
Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase.
Biochemistry 2002;41(36):11000-7.
2002: Preobrazhenska Olena; Yakymovych Mariya; Kanamoto Takashi; Yakymovych Ihor; Stoika Rostyslav; Heldin Carl-Henrik; Souchelnytskyi Serhiy
BRCA2 and Smad3 synergize in regulation of gene transcription.
Oncogene 2002;21(36):5660-4.
2002: Moustakas Aristidis; Heldin Carl-Henrik
From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction.
Genes & development 2002;16(15):1867-71.
2002: Rosendahl Alexander; Pardali Evangelia; Speletas Matthaios; Ten Dijke Peter; Heldin Carl-Henrik; Sideras Paschalis
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation.
American journal of respiratory cell and molecular biology 2002;27(2):160-9.
2002: Souchelnytskyi Serhiy; Moustakas Aristidis; Heldin Carl-Henrik
TGF-beta signaling from a three-dimensional perspective: insight into selection of partners.
Trends in cell biology 2002;12(7):304-7.
2002: Moustakas Aristidis; Pardali Katerina; Gaal Annamaria; Heldin Carl Henrik
Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation.
Immunology letters 2002;82(1-2):85-91.
2002: Eichner Annegret; Brock Josef; Heldin Carl-Henrik; Souchelnytskyi Serhiy
Bone morphogenetic protein-7 (OP1) and transforming growth factor-beta1 modulate 1,25(OH)2-vitamin D3-induced differentiation of human osteoblasts.
Experimental cell research 2002;275(1):132-42.
2002: Edlund Sofia; Landström Maréne; Heldin Carl-Henrik; Aspenström Pontus
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.
Molecular biology of the cell 2002;13(3):902-14.
2002: Ekman Simon; Kallin Anders; Engström Ulla; Heldin Carl-Henrik; Rönnstrand Lars
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor.
Oncogene 2002;21(12):1870-5.
2002: Palumbo Roberta; Gaetano Carlo; Antonini Annalisa; Pompilio Giulio; Bracco Enrico; Rönnstrand Lars; Heldin Carl-Henrik; Capogrossi Maurizio C
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):405-11.
2002: Kanamoto Takashi; Hellman Ulf; Heldin Carl-Henrik; Souchelnytskyi Serhiy
Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair.
The EMBO journal 2002;21(5):1219-30.
2002: Heldin Carl-Henrik; Eriksson Ulf; Ostman Arne
New members of the platelet-derived growth factor family of mitogens.
Archives of biochemistry and biophysics 2002;398(2):284-90.
2001: Moustakas A; Souchelnytskyi S; Heldin C H
Smad regulation in TGF-beta signal transduction.
Journal of cell science 2001;114(Pt 24):4359-69.
2001: Heldin C H; Ericsson J
Signal transduction. RIPping tyrosine kinase receptors apart.
Science (New York, N.Y.) 2001;294(5549):2111-3.
2001: Itoh F; Asao H; Sugamura K; Heldin C H; ten Dijke P; Itoh S
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.
The EMBO journal 2001;20(15):4132-42.
2001: Sjöblom T; Shimizu A; O'Brien K P; Pietras K; Dal Cin P; Buchdunger E; Dumanski J P; Ostman A; Heldin C H
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.
Cancer research 2001;61(15):5778-83.
2001: Rosendahl A; Checchin D; Fehniger T E; ten Dijke P; Heldin C H; Sideras P
Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation.
American journal of respiratory cell and molecular biology 2001;25(1):60-8.
2001: Shimizu A; Persson C; Heldin C H; Ostman A
Ligand stimulation reduces platelet-derived growth factor beta-receptor susceptibility to tyrosine dephosphorylation.
The Journal of biological chemistry 2001;276(30):27749-52.
2001: Bergsten E; Uutela M; Li X; Pietras K; Ostman A; Heldin C H; Alitalo K; Eriksson U
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Nature cell biology 2001;3(5):512-6.
2001: Pietras K; Ostman A; Sjöquist M; Buchdunger E; Reed R K; Heldin C H; Rubin K
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.
Cancer research 2001;61(7):2929-34.
2001: Kurisaki A; Kose S; Yoneda Y; Heldin C H; Moustakas A
Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner.
Molecular biology of the cell 2001;12(4):1079-91.
2001: Pulaski L; Landström M; Heldin C H; Souchelnytskyi S
Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation.
The Journal of biological chemistry 2001;276(17):14344-9.
2001: Rönnstrand L; Heldin C H
Mechanisms of platelet-derived growth factor-induced chemotaxis.
International journal of cancer. Journal international du cancer 2001;91(6):757-62.
2001: Yakymovych I; Ten Dijke P; Heldin C H; Souchelnytskyi S
Regulation of Smad signaling by protein kinase C.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):553-5.
2001: Heldin C H
Growth factor regulation of kinases.
Ernst Schering Research Foundation workshop 2001;(34):1-18.
2001: Ostman A; Heldin C H
Involvement of platelet-derived growth factor in disease: development of specific antagonists.
Advances in cancer research 2001;80():1-38.
2000: Tallquist M D; Klinghoffer R A; Heuchel R; Mueting-Nelsen P F; Corrin P D; Heldin C H; Johnson R J; Soriano P
Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways.
Genes & development 2000;14(24):3179-90.
2000: Leppänen O; Janjic N; Carlsson M A; Pietras K; Levin M; Vargeese C; Green L S; Bergqvist D; Ostman A; Heldin C H
Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):E89-95.
2000: Siegbahn A; Johnell M; Rorsman C; Ezban M; Heldin C H; Rönnstrand L
Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis.
Blood 2000;96(10):3452-8.
2000: Itoh S; Ericsson J; Nishikawa J; Heldin C H; ten Dijke P
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.
Nucleic acids research 2000;28(21):4291-8.
2000: Morén A; Itoh S; Moustakas A; Dijke P; Heldin C H
Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
Oncogene 2000;19(38):4396-404.
2000: Brodin G; Ahgren A; ten Dijke P; Heldin C H; Heuchel R
Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter.
The Journal of biological chemistry 2000;275(37):29023-30.
2000: Hooshmand-Rad R; Lu L; Heldin C H; Claesson-Welsh L; Welsh M
Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.
Experimental cell research 2000;257(2):245-54.
2000: Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin C H; Alitalo K; Ostman A; Eriksson U
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Nature cell biology 2000;2(5):302-9.
2000: Landström M; Heldin N E; Bu S; Hermansson A; Itoh S; ten Dijke P; Heldin C H
Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells.
Current biology : CB 2000;10(9):535-8.
2000: Leppänen O; Miyazawa K; Bäckström G; Pietras K; Sjöblom T; Heldin C H; Ostman A
Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency.
Biochemistry 2000;39(9):2370-5.
2000: ten Dijke P; Miyazono K; Heldin C H
Signaling inputs converge on nuclear effectors in TGF-beta signaling.
Trends in biochemical sciences 2000;25(2):64-70.
2000: Pardali E; Xie X Q; Tsapogas P; Itoh S; Arvanitidis K; Heldin C H; ten Dijke P; Grundström T; Sideras P
Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.
The Journal of biological chemistry 2000;275(5):3552-60.
2000: Paukku K; Valgeirsdóttir S; Saharinen P; Bergman M; Heldin C H; Silvennoinen O
Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases.
The Biochemical journal 2000;345 Pt 3():759-66.
2000: Hooshmand-Rad R; Hájková L; Klint P; Karlsson R; Vanhaesebroeck B; Claesson-Welsh L; Heldin C H
The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling.
Journal of cell science 2000;113 Pt 2():207-14.
1999: Piek E; Heldin C H; Ten Dijke P
Specificity, diversity, and regulation in TGF-beta superfamily signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2105-24.
1999: Piek E; Moustakas A; Kurisaki A; Heldin C H; ten Dijke P
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
Journal of cell science 1999;112 ( Pt 24)():4557-68.
1999: Sjöblom T; Boureux A; Rönnstrand L; Heldin C H; Ghysdael J; Ostman A
Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein.
Oncogene 1999;18(50):7055-62.
1999: Heldin C H; Westermark B
Mechanism of action and in vivo role of platelet-derived growth factor.
Physiological reviews 1999;79(4):1283-316.
1999: Heuchel R; Berg A; Tallquist M; Ahlén K; Reed R K; Rubin K; Claesson-Welsh L; Heldin C H; Soriano P
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11410-5.
1999: Shimizu A; O'Brien K P; Sjöblom T; Pietras K; Buchdunger E; Collins V P; Heldin C H; Dumanski J P; Ostman A
The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.
Cancer research 1999;59(15):3719-23.
1999: Emaduddin M; Ekman S; Rönnstrand L; Heldin C H
Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.
The Biochemical journal 1999;341 ( Pt 3)():523-8.
1999: Piek E; Afrakhte M; Sampath K; van Zoelen E J; Heldin C H; ten Dijke P
Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells.
Journal of cellular physiology 1999;180(2):141-9.
1999: Rönnstrand L; Siegbahn A; Rorsman C; Johnell M; Hansen K; Heldin C H
Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.
The Journal of biological chemistry 1999;274(31):22089-94.
1999: Korchynskyi O; Landström M; Stoika R; Funa K; Heldin C H; ten Dijke P; Souchelnytskyi S
Expression of Smad proteins in human colorectal cancer.
International journal of cancer. Journal international du cancer 1999;82(2):197-202.
1999: Rönnstrand L; Arvidsson A K; Kallin A; Rorsman C; Hellman U; Engström U; Wernstedt C; Heldin C H
SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.
Oncogene 1999;18(25):3696-702.
1999: Brodin G; ten Dijke P; Funa K; Heldin C H; Landström M
Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration.
Cancer research 1999;59(11):2731-8.
1999: Lange D; Persson U; Wollina U; ten Dijke P; Castelli E; Heldin C H; Funa K
Expression of TGF-beta related Smad proteins in human epithelial skin tumors.
International journal of oncology 1999;14(6):1049-56.
1999: Wollina U; Lange D; Ten Dijke P; Heldin C H; Funa K
Eccrine sweat glands: expression of transforming growth factor-beta and bone morphogenetic protein type I receptors and their intracellular signalling Smad proteins.
Acta dermato-venereologica 1999;79(3):183-6.
1999: Valgeirsdóttir S; Ruusala A; Heldin C H
MEK is a negative regulator of Stat5b in PDGF-stimulated cells.
FEBS letters 1999;450(1-2):1-7.
1999: Ekman S; Thuresson E R; Heldin C H; Rönnstrand L
Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding.
Oncogene 1999;18(15):2481-8.
1999: Piek E; Westermark U; Kastemar M; Heldin C H; van Zoelen E J; Nistér M; Ten Dijke P
Expression of transforming-growth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-beta1.
International journal of cancer. Journal international du cancer 1999;80(5):756-63.
1998: Tamaki K; Souchelnytskyi S; Itoh S; Nakao A; Sampath K; Heldin C H; ten Dijke P
Intracellular signaling of osteogenic protein-1 through Smad5 activation.
Journal of cellular physiology 1998;177(2):355-63.
1998: Itóh S; Landström M; Hermansson A; Itoh F; Heldin C H; Heldin N E; ten Dijke P
Transforming growth factor beta1 induces nuclear export of inhibitory Smad7.
The Journal of biological chemistry 1998;273(44):29195-201.
1998: Miyazawa K; Bäckström G; Leppänen O; Persson C; Wernstedt C; Hellman U; Heldin C H; Ostman A
Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly.
The Journal of biological chemistry 1998;273(39):25495-502.
1998: Souchelnytskyi S; Nakayama T; Nakao A; Morén A; Heldin C H; Christian J L; ten Dijke P
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.
The Journal of biological chemistry 1998;273(39):25364-70.
1998: Heldin C H; Ostman A; Rönnstrand L
Signal transduction via platelet-derived growth factor receptors.
Biochimica et biophysica acta 1998;1378(1):F79-113.
1998: Persson U; Izumi H; Souchelnytskyi S; Itoh S; Grimsby S; Engström U; Heldin C H; Funa K; ten Dijke P
The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation.
FEBS letters 1998;434(1-2):83-7.
1998: Afrakhte M; Morén A; Jossan S; Itoh S; Sampath K; Westermark B; Heldin C H; Heldin N E; ten Dijke P
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Biochemical and biophysical research communications 1998;249(2):505-11.
1998: Hyytiäinen M; Taipale J; Heldin C H; Keski-Oja J
Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release.
The Journal of biological chemistry 1998;273(32):20669-76.
1998: Valgeirsdóttir S; Claesson-Welsh L; Bongcam-Rudloff E; Hellman U; Westermark B; Heldin C H
PDGF induces reorganization of vimentin filaments.
Journal of cell science 1998;111 ( Pt 14)():1973-80.
1998: Hooshmand-Rad R; Yokote K; Heldin C H; Claesson-Welsh L
PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells.
Journal of cell science 1998;111 ( Pt 5)():607-14.
1998: Valgeirsdóttir S; Paukku K; Silvennoinen O; Heldin C H; Claesson-Welsh L
Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains.
Oncogene 1998;16(4):505-15.
1997: Hansen K; Alonso G; Courtneidge S A; Rönnstrand L; Heldin C H
PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.
Biochemical and biophysical research communications 1997;241(2):355-62.
1997: Heldin C H; Miyazono K; ten Dijke P
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
Nature 1997;390(6659):465-71.
1997: Piek E; Franzén P; Heldin C H; ten Dijke P
Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding.
Journal of cellular physiology 1997;173(3):447-59.
1997: Souchelnytskyi S; Tamaki K; Engström U; Wernstedt C; ten Dijke P; Heldin C H
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.
The Journal of biological chemistry 1997;272(44):28107-15.
1997: Nakao A; Afrakhte M; Morén A; Nakayama T; Christian J L; Heuchel R; Itoh S; Kawabata M; Heldin N E; Heldin C H; ten Dijke P
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Nature 1997;389(6651):631-5.
1997: Nakao A; Imamura T; Souchelnytskyi S; Kawabata M; Ishisaki A; Oeda E; Tamaki K; Hanai J; Heldin C H; Miyazono K; ten Dijke P
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
The EMBO journal 1997;16(17):5353-62.
1997: Saras J; Franzén P; Aspenström P; Hellman U; Gonez L J; Heldin C H
A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.
The Journal of biological chemistry 1997;272(39):24333-8.
1997: Omura T; Miyazawa K; Ostman A; Heldin C H
Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line.
The Journal of biological chemistry 1997;272(37):23317-22.
1997: Kozawa O; Blume-Jensen P; Heldin C H; Rönnstrand L
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
European journal of biochemistry / FEBS 1997;248(1):149-55.
1997: Persson U; Souchelnytskyi S; Franzén P; Miyazono K; ten Dijke P; Heldin C H
Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor.
The Journal of biological chemistry 1997;272(34):21187-94.
1997: Saras J; Engström U; Góñez L J; Heldin C H
Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas.
The Journal of biological chemistry 1997;272(34):20979-81.
1997: Hooshmand-Rad R; Claesson-Welsh L; Wennström S; Yokote K; Siegbahn A; Heldin C H
Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis.
Experimental cell research 1997;234(2):434-41.
1997: Heldin C H
Simultaneous induction of stimulatory and inhibitory signals by PDGF.
FEBS letters 1997;410(1):17-21.
1997: Hansen K; Rönnstrand L; Rorsman C; Hellman U; Heldin C H
Association of coatomer proteins with the beta-receptor for platelet-derived growth factor.
Biochemical and biophysical research communications 1997;235(3):455-60.
1997: Hansen K; Rönnstrand L; Claesson-Welsh L; Heldin C H
Phosphorylation of a 72-kDa protein in PDGF-stimulated cells which forms complex with c-Crk, c-Fyn and Eps15.
FEBS letters 1997;409(2):195-200.
1997: Olofsson A; Hellman U; Ten Dijke P; Grimsby S; Ichijo H; Morén A; Miyazono K; Heldin C H
Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.
The Biochemical journal 1997;324 ( Pt 2)():427-34.
1997: Kovalenko M; Rönnstrand L; Heldin C H; Loubtchenkov M; Gazit A; Levitzki A; Böhmer F D
Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.
Biochemistry 1997;36(21):6260-9.
1997: Omura T; Heldin C H; Ostman A
Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization.
The Journal of biological chemistry 1997;272(19):12676-82.
1997: Nakao A; Röijer E; Imamura T; Souchelnytskyi S; Stenman G; Heldin C H; ten Dijke P
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway.
The Journal of biological chemistry 1997;272(5):2896-900.
1996: Saras J; Heldin C H
PDZ domains bind carboxy-terminal sequences of target proteins.
Trends in biochemical sciences 1996;21(12):455-8.
1996: Yamashita H; Ten Dijke P; Heldin C H; Miyazono K
Bone morphogenetic protein receptors.
Bone 1996;19(6):569-74.
1996: Souchelnytskyi S; ten Dijke P; Miyazono K; Heldin C H
Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
The EMBO journal 1996;15(22):6231-40.
1996: Yokote K; Margolis B; Heldin C H; Claesson-Welsh L
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
The Journal of biological chemistry 1996;271(48):30942-9.
1996: Hansen K; Johnell M; Siegbahn A; Rorsman C; Engström U; Wernstedt C; Heldin C H; Rönnstrand L
Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.
The EMBO journal 1996;15(19):5299-313.
1996: Heldin C H; Ostman A
Ligand-induced dimerization of growth factor receptors: variations on the theme.
Cytokine & growth factor reviews 1996;7(1):3-10.
1996: Kreysing J; Ostman A; van de Poll M; Bäckström G; Heldin C H
Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF alpha- and beta-receptors.
FEBS letters 1996;385(3):181-4.
1996: ten Dijke P; Miyazono K; Heldin C H
Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.
Current opinion in cell biology 1996;8(2):139-45.
1996: Yokote K; Mori S; Siegbahn A; Rönnstrand L; Wernstedt C; Heldin C H; Claesson-Welsh L
Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.
The Journal of biological chemistry 1996;271(9):5101-11.
1996: Yamada N; Kato M; ten Dijke P; Yamashita H; Sampath T K; Heldin C H; Miyazono K; Funa K
Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.
British journal of cancer 1996;73(5):624-9.
1996: Hermanson M; Funa K; Koopmann J; Maintz D; Waha A; Westermark B; Heldin C H; Wiestler O D; Louis D N; von Deimling A; Nistér M
Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.
Cancer research 1996;56(1):164-71.
1995: Olofsson A; Ichijo H; Morén A; ten Dijke P; Miyazono K; Heldin C H
Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.
The Journal of biological chemistry 1995;270(52):31294-7.
1995: Westermark B; Heldin C H; Nistér M
Platelet-derived growth factor in human glioma.
Glia 1995;15(3):257-63.
1995: Rosenzweig B L; Imamura T; Okadome T; Cox G N; Yamashita H; ten Dijke P; Heldin C H; Miyazono K
Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7632-6.
1995: Yamada N; Kato M; Yamashita H; Nistér M; Miyazono K; Heldin C H; Funa K
Enhanced expression of transforming growth factor-beta and its type-I and type-II receptors in human glioblastoma.
International journal of cancer. Journal international du cancer 1995;62(4):386-92.
1995: Yamashita H; ten Dijke P; Huylebroeck D; Sampath T K; Andries M; Smith J C; Heldin C H; Miyazono K
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
The Journal of cell biology 1995;130(1):217-26.
1995: Verschueren K; Dewulf N; Goumans M J; Lonnoy O; Feijen A; Grimsby S; Vandi Spiegle K; ten Dijke P; Morén A; Vanscheeuwijck P; Heldin C H; Miyazono K; Mummery C; Van Den Eijnden-Van Raaij J; Huylebroeck D
Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis.
Mechanisms of development 1995;52(1):109-23.
1995: Eccleston P A; Funa K; Heldin C H
Neurons of the peripheral nervous system express thymidine phosphorylase.
Neuroscience letters 1995;192(2):137-41.
1995: Blume-Jensen P; Wernstedt C; Heldin C H; Rönnstrand L
Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells.
The Journal of biological chemistry 1995;270(23):14192-200.
1995: Suzuki M; Asplund T; Yamashita H; Heldin C H; Heldin P
Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.
The Biochemical journal 1995;307 ( Pt 3)():817-21.
1995: Kato M; Ishizaki A; Hellman U; Wernstedt C; Kyogoku M; Miyazono K; Heldin C H; Funa K
A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner.
The Journal of biological chemistry 1995;270(21):12373-9.
1995: Valgeirsdóttir S; Eriksson A; Nistér M; Heldin C H; Westermark B; Claesson-Welsh L
Compartmentalization of autocrine signal transduction pathways in Sis-transformed NIH 3T3 cells.
The Journal of biological chemistry 1995;270(17):10161-70.
1995: Eriksson A; Nånberg E; Rönnstrand L; Engström U; Hellman U; Rupp E; Carpenter G; Heldin C H; Claesson-Welsh L
Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors.
The Journal of biological chemistry 1995;270(13):7773-81.
1995: Franzén P; Heldin C H; Miyazono K
The GS domain of the transforming growth factor-beta type I receptor is important in signal transduction.
Biochemical and biophysical research communications 1995;207(2):682-9.
1995: Heldin C H
Dimerization of cell surface receptors in signal transduction.
Cell 1995;80(2):213-23.
1995: Yamashita H; Okadome T; Franzén P; ten Dijke P; Heldin C H; Miyazono K
A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-beta.
The Journal of biological chemistry 1995;270(2):770-4.
1995: Andersson M; Ostman A; Kreysing J; Bäckström G; Van de Poll M; Heldin C H
Involvement of loop 2 of platelet-derived growth factor-AA and -BB in receptor binding.
Growth factors (Chur, Switzerland) 1995;12(2):159-64.
1994: Okadome T; Yamashita H; Franzén P; Morén A; Heldin C H; Miyazono K
Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.
The Journal of biological chemistry 1994;269(49):30753-6.
1994: Kovalenko M; Gazit A; Böhmer A; Rorsman C; Rönnstrand L; Heldin C H; Waltenberger J; Böhmer F D; Levitzki A
Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.
Cancer research 1994;54(23):6106-14.
1994: Morén A; Olofsson A; Stenman G; Sahlin P; Kanzaki T; Claesson-Welsh L; ten Dijke P; Miyazono K; Heldin C H
Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.
The Journal of biological chemistry 1994;269(51):32469-78.
1994: Miyazono K; ten Dijke P; Yamashita H; Heldin C H
Signal transduction via serine/threonine kinase receptors.
Seminars in cell biology 1994;5(6):389-98.
1994: Arvidsson A K; Rupp E; Nånberg E; Downward J; Rönnstrand L; Wennström S; Schlessinger J; Heldin C H; Claesson-Welsh L
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
Molecular and cellular biology 1994;14(10):6715-26.
1994: Waltenberger J; Claesson-Welsh L; Siegbahn A; Shibuya M; Heldin C H
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
The Journal of biological chemistry 1994;269(43):26988-95.
1994: Rupp E; Siegbahn A; Rönnstrand L; Wernstedt C; Claesson-Welsh L; Heldin C H
A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.
European journal of biochemistry / FEBS 1994;225(1):29-41.
1994: Saras J; Claesson-Welsh L; Heldin C H; Gonez L J
Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins.
The Journal of biological chemistry 1994;269(39):24082-9.
1994: Yamashita H; ten Dijke P; Franzén P; Miyazono K; Heldin C H
Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.
The Journal of biological chemistry 1994;269(31):20172-8.
1994: Blume-Jensen P; Rönnstrand L; Gout I; Waterfield M D; Heldin C H
Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C.
The Journal of biological chemistry 1994;269(34):21793-802.
1994: Usuki K; Gonez L J; Wernstedt C; Morén A; Miyazono K; Claesson-Welsh L; Heldin C H
Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells.
Biochimica et biophysica acta 1994;1222(3):411-4.
1994: ten Dijke P; Yamashita H; Sampath T K; Reddi A H; Estevez M; Riddle D L; Ichijo H; Heldin C H; Miyazono K
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
The Journal of biological chemistry 1994;269(25):16985-8.
1994: Taketazu F; Kato M; Gobl A; Ichijo H; ten Dijke P; Itoh J; Kyogoku M; Rönnelid J; Miyazono K; Heldin C H
Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis.
Laboratory investigation; a journal of technical methods and pathology 1994;70(5):620-30.
1994: Yokote K; Mori S; Hansen K; McGlade J; Pawson T; Heldin C H; Claesson-Welsh L
Direct interaction between Shc and the platelet-derived growth factor beta-receptor.
The Journal of biological chemistry 1994;269(21):15337-43.
1994: Vassbotn F S; Havnen O K; Heldin C H; Holmsen H
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
The Journal of biological chemistry 1994;269(19):13874-9.
1994: Nistér M; Enblad P; Bäckström G; Söderman T; Persson L; Heldin C H; Westermark B
Platelet-derived growth factor (PDGF) in neoplastic and non-neoplastic cystic lesions of the central nervous system and in the cerebrospinal fluid.
British journal of cancer 1994;69(5):952-6.
1994: ten Dijke P; Yamashita H; Ichijo H; Franzén P; Laiho M; Miyazono K; Heldin C H
Characterization of type I receptors for transforming growth factor-beta and activin.
Science (New York, N.Y.) 1994;264(5155):101-4.
1994: Wennström S; Siegbahn A; Yokote K; Arvidsson A K; Heldin C H; Mori S; Claesson-Welsh L
Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.
Oncogene 1994;9(2):651-60.
1994: Vassbotn F S; Ostman A; Langeland N; Holmsen H; Westermark B; Heldin C H; Nistér M
Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line.
Journal of cellular physiology 1994;158(2):381-9.
1994: Mori S; Rönnstrand L; Claesson-Welsh L; Heldin C H
A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis.
The Journal of biological chemistry 1994;269(7):4917-21.
1994: Andersson M; Ostman A; Westermark B; Heldin C H
Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain.
The Journal of biological chemistry 1994;269(2):926-30.
1994: Miyazono K; Ten Dijke P; Ichijo H; Heldin C H
Receptors for transforming growth factor-beta.
Advances in immunology 1994;55():181-220.
1994: ten Dijke P; Franzén P; Yamashita H; Ichijo H; Heldin C H; Miyazono K
Serine/threonine kinase receptors.
Progress in growth factor research 1994;5(1):55-72.
1994: Pekny M; Ostman A; Hermansson A; Nistér M; Heldin C H; Westermark B
Differences in binding to the solid substratum and extracellular matrix may explain isoform-specific paracrine effects of platelet-derived growth factor.
Growth factors (Chur, Switzerland) 1994;10(2):77-87.
1993: Franzén P; ten Dijke P; Ichijo H; Yamashita H; Schulz P; Heldin C H; Miyazono K
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
Cell 1993;75(4):681-92.
1993: Blume-Jensen P; Siegbahn A; Stabel S; Heldin C H; Rönnstrand L
Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.
The EMBO journal 1993;12(11):4199-209.
1993: Paulsson Y; Karlsson C; Heldin C H; Westermark B
Density-dependent inhibitory effect of transforming growth factor-beta 1 on human fibroblasts involves the down-regulation of platelet-derived growth factor alpha-receptors.
Journal of cellular physiology 1993;157(1):97-103.
1993: Heldin N E; Usuki K; Bergh J; Westermark B; Heldin C H
Differential expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human lung carcinoma cell lines.
British journal of cancer 1993;68(4):708-11.
1993: ten Dijke P; Ichijo H; Franzén P; Schulz P; Saras J; Toyoshima H; Heldin C H; Miyazono K
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
Oncogene 1993;8(10):2879-87.
1993: Böhmer F D; Böhmer S A; Heldin C H
The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet-derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein-tyrosine phosphatases.
FEBS letters 1993;331(3):276-80.
1993: Ichijo H; Yamashita H; ten Dijke P; Eto Y; Heldin C H; Miyazono K
Characterization of in vivo phosphorylation of activin type II receptor.
Biochemical and biophysical research communications 1993;194(3):1508-14.
1993: Waltenberger J; Wanders A; Fellström B; Miyazono K; Heldin C H; Funa K
Induction of transforming growth factor-beta during cardiac allograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):1147-57.
1993: Vassbotn F S; Andersson M; Westermark B; Heldin C H; Ostman A
Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.
Molecular and cellular biology 1993;13(7):4066-76.
1993: Ichijo H; Hellman U; Wernstedt C; Gonez L J; Claesson-Welsh L; Heldin C H; Miyazono K
Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains.
The Journal of biological chemistry 1993;268(19):14505-13.
1993: Ostman A; Andersson M; Bäckström G; Heldin C H
Assignment of intrachain disulfide bonds in platelet-derived growth factor B-chain.
The Journal of biological chemistry 1993;268(18):13372-7.
1993: Heldin C H; Westermark B
Possible in vivo effect and clinical utility of platelet-derived growth factor and PDGF antagonists.
Transplantation proceedings 1993;25(2):2074-6.
1993: Waltenberger J; Miyazono K; Funa K; Wanders A; Fellström B; Heldin C H
Transforming growth factor-beta and organ transplantation.
Transplantation proceedings 1993;25(2):2038-40.
1993: Colosetti P; Hellman U; Heldin C H; Miyazono K
Ca2+ binding of latent transforming growth factor-beta 1 binding protein.
FEBS letters 1993;320(2):140-4.
1993: Miyazono K; Heldin C H
The mechanism of action of transforming growth factor-beta.
Gastroenterologia Japonica 1993;28 Suppl 4():81-5; discussion 86-7.
1993: Smits A; Odin P; Duan W M; Brundin P; Widner H; Heldin C H; Lindvall O; Funa K
Expression of platelet-derived growth factor in and around intrastriatal embryonic mesencephalic grafts.
Cell transplantation 1993;2(2):151-62.
1993: Eccleston P A; Funa K; Heldin C H
Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia.
Developmental biology 1993;155(2):459-70.
1993: Waltenberger J; Lundin L; Oberg K; Wilander E; Miyazono K; Heldin C H; Funa K
Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease.
The American journal of pathology 1993;142(1):71-8.
1993: Forsberg K; Valyi-Nagy I; Heldin C H; Herlyn M; Westermark B
Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):393-7.
1993: Mori S; Heldin C H; Claesson-Welsh L
Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.
The Journal of biological chemistry 1993;268(1):577-83.
1993: Miyazono K; Ichijo H; Heldin C H
Transforming growth factor-beta: latent forms, binding proteins and receptors.
Growth factors (Chur, Switzerland) 1993;8(1):11-22.
1993: Heldin C H; Ostman A; Westermark B
Structure of platelet-derived growth factor: implications for functional properties.
Growth factors (Chur, Switzerland) 1993;8(4):245-52.
1993: Westermark B; Heldin C H
Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth.
Acta oncologica (Stockholm, Sweden) 1993;32(2):101-5.
1993: Van Zoelen E J; Van Rotterdam W; Van de Wetering R A; Heldin C H
Differential effects of PDGF isoforms on proliferation of normal rat kidney cells.
Growth factors (Chur, Switzerland) 1993;9(4):329-39.
1992: Arvidsson A K; Heldin C H; Claesson-Welsh L
Transduction of circular membrane ruffling by the platelet-derived growth factor beta-receptor is dependent on its kinase insert.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(12):881-7.
1992: Heldin C H
Structural and functional studies on platelet-derived growth factor.
The EMBO journal 1992;11(12):4251-9.
1992: Waltenberger J; Usuki K; Fellström B; Funa K; Heldin C H
Platelet-derived endothelial cell growth factor. Pharmacokinetics, organ distribution and degradation after intravenous administration in rats.
FEBS letters 1992;313(2):129-32.
1992: Rönnstrand L; Mori S; Arridsson A K; Eriksson A; Wernstedt C; Hellman U; Claesson-Welsh L; Heldin C H
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.
The EMBO journal 1992;11(11):3911-9.
1992: Olofsson A; Miyazono K; Kanzaki T; Colosetti P; Engström U; Heldin C H
Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.
The Journal of biological chemistry 1992;267(27):19482-8.
1992: Ostman A; Thyberg J; Westermark B; Heldin C H
PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly.
The Journal of cell biology 1992;118(3):509-19.
1992: Engström U; Engström A; Ernlund A; Westermark B; Heldin C H
Identification of a peptide antagonist for platelet-derived growth factor.
The Journal of biological chemistry 1992;267(23):16581-7.
1992: Vassbotn F S; Ostman A; Siegbahn A; Holmsen H; Heldin C H
Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types.
The Journal of biological chemistry 1992;267(22):15635-41.
1992: Tingström A; Heldin C H; Rubin K
Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 alpha and transforming growth factor-beta 1.
Journal of cell science 1992;102 ( Pt 2)():315-22.
1992: Andersson M; Ostman A; Bäckström G; Hellman U; George-Nascimento C; Westermark B; Heldin C H
Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF.
The Journal of biological chemistry 1992;267(16):11260-6.
1992: Hermanson M; Funa K; Hartman M; Claesson-Welsh L; Heldin C H; Westermark B; Nistér M
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.
Cancer research 1992;52(11):3213-9.
1992: Usuki K; Saras J; Waltenberger J; Miyazono K; Pierce G; Thomason A; Heldin C H
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
Biochemical and biophysical research communications 1992;184(3):1311-6.
1992: Miyazono K; Thyberg J; Heldin C H
Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form.
The Journal of biological chemistry 1992;267(8):5668-75.
1992: Smits A; Funa K; Vassbotn F S; Beausang-Linder M; af Ekenstam F; Heldin C H; Westermark B; Nistér M
Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.
The American journal of pathology 1992;140(3):639-48.
1992: Heldin C H; Ostman A; Eriksson A; Siegbahn A; Claesson-Welsh L; Westermark B
Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes.
Kidney international 1992;41(3):571-4.
1992: Mori S; Heldin C H; Claesson-Welsh L
Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.
The Journal of biological chemistry 1992;267(9):6429-34.
1992: Eriksson A; Siegbahn A; Westermark B; Heldin C H; Claesson-Welsh L
PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.
The EMBO journal 1992;11(2):543-50.
1992: Tingström A; Reuterdahl C; Lindahl P; Heldin C H; Rubin K
Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(2):546-54.
1992: Stenman G; Sahlin P; Dumanski J P; Hagiwara K; Ishikawa F; Miyazono K; Collins V P; Heldin C H
Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13.
Cytogenetics and cell genetics 1992;59(1):22-3.
1992: Eriksson A; Rorsman C; Ernlund A; Claesson-Welsh L; Heldin C H
Ligand-induced homo- and hetero-dimerization of platelet-derived growth factor alpha- and beta-receptors in intact cells.
Growth factors (Chur, Switzerland) 1992;6(1):1-14.
1991: Heldin C H
SH2 domains: elements that control protein interactions during signal transduction.
Trends in biochemical sciences 1991;16(12):450-2.
1991: Blume-Jensen P; Claesson-Welsh L; Siegbahn A; Zsebo K M; Westermark B; Heldin C H
Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.
The EMBO journal 1991;10(13):4121-8.
1991: Heldin C H; Usuki K; Miyazono K
Platelet-derived endothelial cell growth factor.
Journal of cellular biochemistry 1991;47(3):208-10.
1991: Ichijo H; Rönnstrand L; Miyagawa K; Ohashi H; Heldin C H; Miyazono K
Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes.
The Journal of biological chemistry 1991;266(33):22459-64.
1991: Mori S; Claesson-Welsh L; Heldin C H
Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis.
The Journal of biological chemistry 1991;266(31):21158-64.
1991: Eriksson A; Nistér M; Leveen P; Westermark B; Heldin C H; Claesson-Welsh L
Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB.
The Journal of biological chemistry 1991;266(31):21138-44.
1991: Usuki K; Miyazono K; Heldin C H
Covalent linkage between nucleotides and platelet-derived endothelial cell growth factor.
The Journal of biological chemistry 1991;266(30):20525-31.
1991: Westermark B; Heldin C H
Platelet-derived growth factor in autocrine transformation.
Cancer research 1991;51(19):5087-92.
1991: Smits A; Kato M; Westermark B; Nistér M; Heldin C H; Funa K
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8159-63.
1991: Nistér M; Claesson-Welsh L; Eriksson A; Heldin C H; Westermark B
Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.
The Journal of biological chemistry 1991;266(25):16755-63.
1991: Ostman A; Andersson M; Betsholtz C; Westermark B; Heldin C H
Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.
Cell regulation 1991;2(7):503-12.
1991: Ostman A; Andersson M; Hellman U; Heldin C H
Identification of three amino acids in the platelet-derived growth factor (PDGF) B-chain that are important for binding to the PDGF beta-receptor.
The Journal of biological chemistry 1991;266(16):10073-7.
1991: Miyazono K; Olofsson A; Colosetti P; Heldin C H
A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.
The EMBO journal 1991;10(5):1091-101.
1991: Hagiwara K; Stenman G; Honda H; Sahlin P; Andersson A; Miyazono K; Heldin C H; Ishikawa F; Takaku F
Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene.
Molecular and cellular biology 1991;11(4):2125-32.
1991: Heldin P; Pertoft H; Nordlinder H; Heldin C H; Laurent T C
Differential expression of platelet-derived growth factor alpha- and beta- receptors on fat-storing cells and endothelial cells of rat liver.
Experimental cell research 1991;193(2):364-9.
1991: Reuterdahl C; Tingström A; Terracio L; Funa K; Heldin C H; Rubin K
Characterization of platelet-derived growth factor beta-receptor expressing cells in the vasculature of human rheumatoid synovium.
Laboratory investigation; a journal of technical methods and pathology 1991;64(3):321-9.
1991: Sorkin A; Westermark B; Heldin C H; Claesson-Welsh L
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.
The Journal of cell biology 1991;112(3):469-78.
1991: Miyazono K; Heldin C H
Latent forms of TGF-beta: molecular structure and mechanisms of activation.
Ciba Foundation symposium 1991;157():81-9; discussion 89-92.
1991: Miyazono K; Usuki K; Heldin C H
Platelet-derived endothelial cell growth factor.
Progress in growth factor research 1991;3(3):207-17.
1991: Heldin C H; Westermark B
Platelet-derived growth factor and autocrine mechanisms of oncogenic processes.
Critical reviews in oncogenesis 1991;2(2):109-24.
1990: Leveen P; Claesson-Welsh L; Heldin C H; Westermark B; Betsholtz C
Expression of messenger RNAs for platelet-derived growth factor and its receptors in human sarcoma cell lines.
International journal of cancer. Journal international du cancer 1990;46(6):1066-70.
1990: Thyberg J; Ostman A; Bäckström G; Westermark B; Heldin C H
Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: retention of PDGF-BB in the endoplasmic reticulum and Golgi complex.
Journal of cell science 1990;97 ( Pt 2)():219-29.
1990: Welsh M; Claesson-Welsh L; Hallberg A; Welsh N; Betsholtz C; Arkhammar P; Nilsson T; Heldin C H; Berggren P O
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5807-11.
1990: Usuki K; Norberg L; Larsson E; Miyazono K; Hellman U; Wernstedt C; Rubin K; Heldin C H
Localization of platelet-derived endothelial cell growth factor in human placenta and purification of an alternatively processed form.
Cell regulation 1990;1(8):577-84.
1990: Heldin C H; Westermark B
Platelet-derived growth factor: mechanism of action and possible in vivo function.
Cell regulation 1990;1(8):555-66.
1990: Kanzaki T; Olofsson A; Morén A; Wernstedt C; Hellman U; Miyazono K; Claesson-Welsh L; Heldin C H
TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.
Cell 1990;61(6):1051-61.
1990: Heldin C H; Westermark B
Signal transduction by the receptors for platelet-derived growth factor.
Journal of cell science 1990;96 ( Pt 2)():193-6.
1990: Jin P; Rahm M; Claesson-Welsh L; Heldin C H; Sejersen T
Expression of PDGF A-chain and beta-receptor genes during rat myoblast differentiation.
The Journal of cell biology 1990;110(5):1665-72.
1990: Rönnstrand L; Sorokin A; Engström U; Heldin C H
Characterization of the platelet-derived growth factor beta-receptor kinase activity by use of synthetic peptides.
Biochemical and biophysical research communications 1990;167(3):1333-40.
1990: Siegbahn A; Hammacher A; Westermark B; Heldin C H
Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.
The Journal of clinical investigation 1990;85(3):916-20.
1990: Severinsson L; Ek B; Mellström K; Claesson-Welsh L; Heldin C H
Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.
Molecular and cellular biology 1990;10(2):801-9.
1990: Westermark B; Siegbahn A; Heldin C H; Claesson-Welsh L
B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):128-32.
1990: Miyazono K; Yuki K; Takaku F; Wernstedt C; Kanzaki T; Olofsson A; Hellman U; Heldin C H
Latent forms of TGF-beta: structure and biology.
Annals of the New York Academy of Sciences 1990;593():51-8.
1990: Sjölund M; Rahm M; Claesson-Welsh L; Sejersen T; Heldin C H; Thyberg J
Expression of PDGF alpha- and beta-receptors in rat arterial smooth muscle cells is phenotype and growth state dependent.
Growth factors (Chur, Switzerland) 1990;3(3):191-203.
1990: Westermark B; Claesson-Welsh L; Heldin C H
Structural and functional aspects of platelet-derived growth factor and its receptors.
Ciba Foundation symposium 1990;150():6-14; discussion 14-22.
1989: Fellström B; Klareskog L; Heldin C H; Larsson E; Rönnstrand L; Terracio L; Tufveson G; Wahlberg J; Rubin K
Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.
Kidney international 1989;36(6):1099-102.
1989: Hammacher A; Nistér M; Heldin C H
The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response.
The Biochemical journal 1989;264(1):15-20.
1989: Heldin C H; Westermark B
Growth factors as transforming proteins.
European journal of biochemistry / FEBS 1989;184(3):487-96.
1989: Usuki K; Heldin N E; Miyazono K; Ishikawa F; Takaku F; Westermark B; Heldin C H
Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7427-31.
1989: Hammacher A; Mellström K; Heldin C H; Westermark B
Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.
The EMBO journal 1989;8(9):2489-95.
1989: Severinsson L; Claesson-Welsh L; Heldin C H
A B-type PDGF receptor lacking most of the intracellular domain escapes degradation after ligand binding.
European journal of biochemistry / FEBS 1989;182(3):679-86.
1989: Claesson-Welsh L; Eriksson A; Westermark B; Heldin C H
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4917-21.
1989: Heldin C H; Ernlund A; Rorsman C; Rönnstrand L
Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation.
The Journal of biological chemistry 1989;264(15):8905-12.
1989: Westermark B; Heldin C H
Growth factors and their receptors.
Current opinion in cell biology 1989;1(2):279-85.
1989: Ishikawa F; Miyazono K; Hellman U; Drexler H; Wernstedt C; Hagiwara K; Usuki K; Takaku F; Risau W; Heldin C H
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
Nature 1989;338(6216):557-62.
1989: Heldin P; Laurent T C; Heldin C H
Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts.
The Biochemical journal 1989;258(3):919-22.
1989: Miyazono K; Heldin C H
Role for carbohydrate structures in TGF-beta 1 latency.
Nature 1989;338(6211):158-60.
1989: Betsholtz C; Nistér M; Rorsman F; Heldin C H; Westermark B
Structural and functional aspects of platelet-derived growth factor and its role in the pathogenesis of glioblastoma.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1989;10(1):27-36.
1989: Miyazono K; Heldin C H
High-yield purification of platelet-derived endothelial cell growth factor: structural characterization and establishment of a specific antiserum.
Biochemistry 1989;28(4):1704-10.
1989: Paulsson Y; Austgulen R; Hofsli E; Heldin C H; Westermark B; Nissen-Meyer J
Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts.
Experimental cell research 1989;180(2):490-6.
1989: Claesson-Welsh L; Hammacher A; Westermark B; Heldin C H; Nistér M
Identification and structural analysis of the A type receptor for platelet-derived growth factor. Similarities with the B type receptor.
The Journal of biological chemistry 1989;264(3):1742-7.
1989: Heldin N E; Paulsson Y; Forsberg K; Heldin C H; Westermark B
Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c-myc messenger RNA and inhibition of 3H-thymidine incorporation in human fibroblasts.
Journal of cellular physiology 1989;138(1):17-23.
1989: Westermark B; Claesson-Welsh L; Heldin C H
Structural and functional aspects of the receptors for platelet-derived growth factor.
Progress in growth factor research 1989;1(4):253-66.
1989: Smits A; Hermansson M; Nistér M; Karnushina I; Heldin C H; Westermark B; Funa K
Rat brain capillary endothelial cells express functional PDGF B-type receptors.
Growth factors (Chur, Switzerland) 1989;2(1):1-8.
1989: Ostman A; Bäckström G; Fong N; Betsholtz C; Wernstedt C; Hellman U; Westermark B; Valenzuela P; Heldin C H
Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities.
Growth factors (Chur, Switzerland) 1989;1(3):271-81.
1989: Claesson-Welsh L; Heldin C H
Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.
Acta oncologica (Stockholm, Sweden) 1989;28(3):331-4.
1989: Heldin C H; Miyazono K; Claesson-Welsh L; Westermark B
Growth regulatory proteins from human platelets.
Princess Takamatsu symposia 1989;20():81-92.
1988: Heldin N E; Gustavsson B; Claesson-Welsh L; Hammacher A; Mark J; Heldin C H; Westermark B
Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9302-6.
1988: Terracio L; Rönnstrand L; Tingström A; Rubin K; Claesson-Welsh L; Funa K; Heldin C H
Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.
The Journal of cell biology 1988;107(5):1947-57.
1988: Ostman A; Rall L; Hammacher A; Wormstead M A; Coit D; Valenzuela P; Betsholtz C; Westermark B; Heldin C H
Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.
The Journal of biological chemistry 1988;263(31):16202-8.
1988: Hammacher A; Hellman U; Johnsson A; Ostman A; Gunnarsson K; Westermark B; Wasteson A; Heldin C H
A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.
The Journal of biological chemistry 1988;263(31):16493-8.
1988: Hermansson M; Nistér M; Betsholtz C; Heldin C H; Westermark B; Funa K
Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7748-52.
1988: Hammacher A; Nistér M; Westermark B; Heldin C H
A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet-derived growth factor.
European journal of biochemistry / FEBS 1988;176(1):179-86.
1988: Mellström K; Heldin C H; Westermark B
Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor.
Experimental cell research 1988;177(2):347-59.
1988: Claesson-Welsh L; Eriksson A; Morén A; Severinsson L; Ek B; Ostman A; Betsholtz C; Heldin C H
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
Molecular and cellular biology 1988;8(8):3476-86.
1988: Bywater M; Rorsman F; Bongcam-Rudloff E; Mark G; Hammacher A; Heldin C H; Westermark B; Betsholtz C
Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects.
Molecular and cellular biology 1988;8(7):2753-62.
1988: Rönnstrand L; Terracio L; Claesson-Welsh L; Heldin C H; Rubin K
Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor.
The Journal of biological chemistry 1988;263(21):10429-35.
1988: Nistér M; Libermann T A; Betsholtz C; Pettersson M; Claesson-Welsh L; Heldin C H; Schlessinger J; Westermark B
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
Cancer research 1988;48(14):3910-8.
1988: Rubin K; Tingström A; Hansson G K; Larsson E; Rönnstrand L; Klareskog L; Claesson-Welsh L; Heldin C H; Fellström B; Terracio L
Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions.
Lancet 1988;1(8599):1353-6.
1988: Heldin C H; Hammacher A; Nistér M; Westermark B
Structural and functional aspects of platelet-derived growth factor.
British journal of cancer 1988;57(6):591-3.
1988: Miyazono K; Hellman U; Wernstedt C; Heldin C H
Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.
The Journal of biological chemistry 1988;263(13):6407-15.
1988: Heldin C H; Bäckström G; Ostman A; Hammacher A; Rönnstrand L; Rubin K; Nistér M; Westermark B
Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.
The EMBO journal 1988;7(5):1387-93.
1988: Nistér M; Hammacher A; Mellström K; Siegbahn A; Rönnstrand L; Westermark B; Heldin C H
A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets.
Cell 1988;52(6):791-9.
1988: Rubin K; Terracio L; Rönnstrand L; Heldin C H; Klareskog L
Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation.
Scandinavian journal of immunology 1988;27(3):285-94.
1988: Sjölund M; Hedin U; Sejersen T; Heldin C H; Thyberg J
Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner.
The Journal of cell biology 1988;106(2):403-13.
1988: Paulsson Y; Beckmann M P; Westermark B; Heldin C H
Density-dependent inhibition of cell growth by transforming growth factor-beta 1 in normal human fibroblasts.
Growth factors (Chur, Switzerland) 1988;1(1):19-27.
1987: Claesson-Welsh L; Rönnstrand L; Heldin C H
Biosynthesis and intracellular transport of the receptor for platelet-derived growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8796-800.
1987: Heldin C H; Betsholtz C; Claesson-Welsh L; Westermark B
Subversion of growth regulatory pathways in malignant transformation.
Biochimica et biophysica acta 1987;907(3):219-44.
1987: Paulsson Y; Bywater M; Heldin C H; Westermark B
Effects of epidermal growth factor and platelet-derived growth factor on c-fos and c-myc mRNA levels in normal human fibroblasts.
Experimental cell research 1987;171(1):186-94.
1987: Betsholtz C; Bergh J; Bywater M; Pettersson M; Johnsson A; Heldin C H; Ohlsson R; Knott T J; Scott J; Bell G I
Expression of multiple growth factors in a human lung cancer cell line.
International journal of cancer. Journal international du cancer 1987;39(4):502-7.
1987: Heldin C H; Westermark B
PDGF-like growth factors in autocrine stimulation of growth.
Journal of cellular physiology. Supplement 1987;Suppl 5():31-4.
1986: Westermark B; Johnsson A; Paulsson Y; Betsholtz C; Heldin C H; Herlyn M; Rodeck U; Koprowski H
Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7197-200.
1986: Sejersen T; Betsholtz C; Sjölund M; Heldin C H; Westermark B; Thyberg J
Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6844-8.
1986: Paulsson Y; Bywater M; Pfeifer-Ohlsson S; Ohlsson R; Nilsson S; Heldin C H; Westermark B; Betsholtz C
Growth factors induce early pre-replicative changes in senescent human fibroblasts.
The EMBO journal 1986;5(9):2157-62.
1985: Nilsson J; Sjölund M; Palmberg L; Thyberg J; Heldin C H
Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(13):4418-22.
1985: Goustin A S; Betsholtz C; Pfeifer-Ohlsson S; Persson H; Rydnert J; Bywater M; Holmgren G; Heldin C H; Westermark B; Ohlsson R
Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth.
Cell 1985;41(1):301-12.

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