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Paraskevi Heldin

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Inna Kozlova; Aino Ruusala; Spyros S Skandalis; Oleksandr Voytyuk; Paraskevi Heldin
IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation.
Berit Bernert; Helena Porsch; Paraskevi Heldin
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
Suniti Misra; Spyros S Skandalis; Vincent C Hascall; Paraskevi Heldin; Nikos Karamanos; Roger R Markwald; Shibnath Ghatak
Hyaluronan-CD44 interactions as potential targets for cancer therapy.

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All Publications

2012: Inna Kozlova; Aino Ruusala; Spyros S Skandalis; Oleksandr Voytyuk; Paraskevi Heldin
IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation.
Cellular signalling 2012;24(9):1856-62.
2011: Berit Bernert; Helena Porsch; Paraskevi Heldin
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
The Journal of biological chemistry 2011;286(49):42349-59.
2011: Suniti Misra; Spyros S Skandalis; Vincent C Hascall; Paraskevi Heldin; Nikos Karamanos; Roger R Markwald; Shibnath Ghatak
Hyaluronan-CD44 interactions as potential targets for cancer therapy.
The FEBS journal 2011;278(9):1429-43.
2010: Spyros S Skandalis; Inna Kozlova; Ulla Engström; Ulf Hellman; Paraskevi Heldin
Proteomic identification of CD44 interacting proteins.
IUBMB life 2010;62(11):833-40.
2008: Paraskevi Heldin; Evgenia G Karousou; Berit Bernert; Helena Porsch; Koichi Nishitsuka; Spyros S Skandalis
Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis.
Connective tissue research 2008;49(3):215-8.
2007: Yuejuan Li; Lingli Li; Tracey Brown; Paraskevi Heldin
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
International journal of cancer. Journal international du cancer 2007;120(12):2557-67.
2007: Lingli Li; Trias Asteriou; Berit Bernert; Carl-Henrik Heldin; Paraskevi Heldin
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.
The Biochemical journal 2007;404(2):327-36.
2006: Lingli Li; Carl-Henrik Heldin; Paraskevi Heldin
Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44.
The Journal of biological chemistry 2006;281(36):26512-9.
2005: Yoshinori Takahashi; Lingli Li; Masaru Kamiryo; Trias Asteriou; Aristidis Moustakas; Hidetoshi Yamashita; Paraskevi Heldin
Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner.
The Journal of biological chemistry 2005;280(25):24195-204.
2004: Viktoria Göransson; Cecilia Johnsson; Annica Jacobson; Paraskevi Heldin; Roger Hällgren; Peter Hansell
Renal hyaluronan accumulation and hyaluronan synthase expression after ischaemia-reperfusion injury in the rat.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(4):823-30.
2003: Annica Jacobson; Salnikov Alexei; Ellen Lammerts; Pernilla Roswall; Christian Sundberg; Paraskevi Heldin; Kristofer Rubin; Nils-Erik Heldin
Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.
Biochemical and biophysical research communications 2003;305(4):1017-23.
2002: Annica Jacobson; Mehdi Rahmanian; Kristofer Rubin; Paraskevi Heldin
Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.
International journal of cancer. Journal international du cancer 2002;102(3):212-9.
2002: Mehdi Rahmanian; Paraskevi Heldin
Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism.
International journal of cancer. Journal international du cancer 2002;97(5):601-7.
2001: Y Li; Paraskevi Heldin
Hyaluronan production increases the malignant properties of mesothelioma cells.
British journal of cancer 2001;85(4):600-7.
2000: Y Li; Mehdi Rahmanian; Charles Widström; G Lepperdinger; G I Frost; Paraskevi Heldin
Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I and III collagen gene expression.
American journal of respiratory cell and molecular biology 2000;23(3):411-8.
2000: Annica Jacobson; J Brinck; M J Briskin; A P Spicer; Paraskevi Heldin
Expression of human hyaluronan synthases in response to external stimuli.
The Biochemical journal 2000;348 Pt 1():29-35.
1999: J Brinck; Paraskevi Heldin
Expression of recombinant hyaluronan synthase (HAS) isoforms in CHO cells reduces cell migration and cell surface CD44.
Experimental cell research 1999;252(2):342-51.
1998: T Asplund; J Brinck; M Suzuki; M J Briskin; Paraskevi Heldin
Characterization of hyaluronan synthase from a human glioma cell line.
Biochimica et biophysica acta 1998;1380(3):377-88.
1997: Mehdi Rahmanian; H Pertoft; S Kanda; Rolf Christofferson; Lena Claesson-Welsh; Paraskevi Heldin
Hyaluronan oligosaccharides induce tube formation of a brain endothelial cell line in vitro.
Experimental cell research 1997;237(1):223-30.
1997: P Teder; Paraskevi Heldin
Mechanism of impaired local hyaluronan turnover in bleomycin-induced lung injury in rat.
American journal of respiratory cell and molecular biology 1997;17(3):376-85.
1997: Hans Johnsson; Paraskevi Heldin; Gunnar Sedin; T C Laurent
Hyaluronan production in vitro by fetal lung fibroblasts and epithelial cells exposed to surfactants of N-acetylcysteine.
Upsala journal of medical sciences 1997;102(3):199-209.
1996: A M Shyjan; Paraskevi Heldin; E C Butcher; T Yoshino; M J Briskin
Functional cloning of the cDNA for a human hyaluronan synthase.
The Journal of biological chemistry 1996;271(38):23395-9.
1996: P Teder; M A Versnel; Paraskevi Heldin
Stimulatory effects of pleural fluids from mesothelioma patients on CD44 expression, hyaluronan production and cell proliferation in primary cultures of normal mesothelial and transformed cells.
International journal of cancer. Journal international du cancer 1996;67(3):393-8.
1996: D Vrochides; V Papanikolaou; H Pertoft; A A Antoniades; Paraskevi Heldin
Biosynthesis and degradation of hyaluronan by nonparenchymal liver cells during liver regeneration.
Hepatology (Baltimore, Md.) 1996;23(6):1650-5.
1995: Paraskevi Heldin; M Suzuki; P Teder; H Pertoft
Chondroitin sulfate proteoglycan modulates the permeability of hyaluronan-containing coats around normal human mesothelial cells.
Journal of cellular physiology 1995;165(1):54-61.
1995: P Teder; Jonas Bergh; Paraskevi Heldin
Functional hyaluronan receptors are expressed on a squamous cell lung carcinoma cell line but not on other lung carcinoma cell lines.
Cancer research 1995;55(17):3908-14.
1995: M Suzuki; T Asplund; H Yamashita; Carl-Henrik Heldin; Paraskevi Heldin
Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.
The Biochemical journal 1995;307 ( Pt 3)():817-21.
1995: P Teder; O Nettelbladt; Paraskevi Heldin
Characterization of the mechanism involved in bleomycin-induced increased hyaluronan production in rat lung.
American journal of respiratory cell and molecular biology 1995;12(2):181-9.
1994: T Asplund; Paraskevi Heldin
Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells.
Cancer research 1994;54(16):4516-23.
1993: Paraskevi Heldin; H Pertoft
Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells.
Experimental cell research 1993;208(2):422-9.
1993: T Asplund; M A Versnel; T C Laurent; Paraskevi Heldin
Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts.
Cancer research 1993;53(2):388-92.
1992: Paraskevi Heldin; T Asplund; D Ytterberg; S Thelin; T C Laurent
Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells.
The Biochemical journal 1992;283 ( Pt 1)():165-70.
1991: Paraskevi Heldin; H Pertoft; H Nordlinder; Carl-Henrik Heldin; T C Laurent
Differential expression of platelet-derived growth factor alpha- and beta- receptors on fat-storing cells and endothelial cells of rat liver.
Experimental cell research 1991;193(2):364-9.
1989: Paraskevi Heldin; T C Laurent; Carl-Henrik Heldin
Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts.
The Biochemical journal 1989;258(3):919-22.
1987: Paraskevi Heldin
Phosphorylation in vitro of human fibrinogen with casein kinase TS and characterization of phosphorylated sites.
Archives of biochemistry and biophysics 1987;257(2):269-75.
1987: Paraskevi Heldin; B Hessel; E Humble; B Blombäck; L Engström
Effect of phosphorylation in vitro of human fibrinogen with protein kinase C on thrombin-induced gelation.
Thrombosis research 1987;47(1):93-9.
1987: Paraskevi Heldin; E Humble
Phosphorylation of human fibrinogen in vitro with protein kinase C: characterization of the phosphorylated sites.
Archives of biochemistry and biophysics 1987;252(1):49-59.
1985: E Humble; Paraskevi Heldin; P O Forsberg; L Engström
Phosphorylation in vitro of fibrinogen from three mammalian species with four different protein kinases.
Archives of biochemistry and biophysics 1985;241(1):225-31.
1984: E Humble; Paraskevi Heldin; P O Forsberg; L Engström
Phosphorylation of human fibrinogen in vitro by calcium-activated phospholipid-dependent protein kinase from pig spleen.
Journal of biochemistry 1984;95(5):1435-43.