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David Helfman

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Chemicals & Drugs

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Xiaoyu Jiang; Xiaoqing Lu; George McNamara; Xiaofei Liu; Elena Cubedo; Kristopher A Sarosiek; Isidro Sánchez-García; David M Helfman; Izidore S Lossos
HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.
Patrick G Flynn; David M Helfman
Non-muscle myosin IIB helps mediate TNF cell death signaling independent of actomyosin contractility (AMC).
Michelle D Larrea; Feng Hong; Seth A Wander; Thiago G da Silva; David M Helfman; Deborah Lannigan; Jeffrey A Smith; Joyce M Slingerland
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.

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2010: Xiaoyu Jiang; Xiaoqing Lu; George McNamara; Xiaofei Liu; Elena Cubedo; Kristopher A Sarosiek; Isidro Sánchez-García; David M Helfman; Izidore S Lossos
HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.
Blood 2010;116(24):5217-27.
2010: Patrick G Flynn; David M Helfman
Non-muscle myosin IIB helps mediate TNF cell death signaling independent of actomyosin contractility (AMC).
Journal of cellular biochemistry 2010;110(6):1365-75.
2009: Michelle D Larrea; Feng Hong; Seth A Wander; Thiago G da Silva; David M Helfman; Deborah Lannigan; Jeffrey A Smith; Joyce M Slingerland
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9268-73.
2008: David M Helfman; Patrick Flynn; Protiti Khan; Ali Saeed
Tropomyosin as a regulator of cancer cell transformation.
Advances in experimental medicine and biology 2008;644():124-31.
2007: Xiaoqing Lu; Jun Chen; Raquel Malumbres; Elena Cubedo Gil; David M Helfman; Izidore S Lossos
HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.
Blood 2007;110(13):4268-77.
2006: Laureen E Connell; David M Helfman
Myosin light chain kinase plays a role in the regulation of epithelial cell survival.
Journal of cell science 2006;119(Pt 11):2269-81.
2005: David M Helfman; Geraldine Pawlak
Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras.
Journal of cellular biochemistry 2005;95(5):1069-80.
2005: David M Helfman; E J Kim; E Lukanidin; Mariam Grigorian
The metastasis associated protein S100A4: role in tumour progression and metastasis.
British journal of cancer 2005;92(11):1955-8.
2004: Andrei V Bakin; Alfiya Safina; Cammie Rinehart; Cecilia Daroqui; H Darbary; David M Helfman
A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.
Molecular biology of the cell 2004;15(10):4682-94.
2004: Jyotsna Dhawan; David M Helfman
Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation.
Journal of cell science 2004;117(Pt 17):3735-48.
2004: Geraldine Pawlak; Terence W McGarvey; Trang B Nguyen; John E Tomaszewski; Raghunath Puthiyaveettil; S Bruce Malkowicz; David M Helfman
Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder.
International journal of cancer. Journal international du cancer 2004;110(3):368-73.
2004: Sungwoo Lee; David M Helfman
Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway.
The Journal of biological chemistry 2004;279(3):1885-91.
2003: Edward J Kim; David M Helfman
Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin.
The Journal of biological chemistry 2003;278(32):30063-73.
2002: Geraldine Pawlak; David M Helfman
MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway.
The Journal of biological chemistry 2002;277(30):26927-33.
2002: Esteban Araya; Christine BERTHIER; Edward Kim; Trevor Yeung; Xiaorong Wang; David M Helfman
Regulation of coiled-coil assembly in tropomyosins.
Journal of structural biology 2002;137(1-2):176-83.
2002: Geraldine Pawlak; David M Helfman
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.
Molecular biology of the cell 2002;13(1):336-47.
2001: Geraldine Pawlak; David M Helfman
Cytoskeletal changes in cell transformation and tumorigenesis.
Current opinion in genetics & development 2001;11(1):41-7.
2000: Lanping Amy Sung; K M Gao; LJ Yee; Constance J Temm-Grove; David M Helfman; Jim J-C Lin; M Mehrpouryan
Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons.
Blood 2000;95(4):1473-80.
1999: David M Helfman; E T Levy; Christine BERTHIER; Michael Shtutman; Daniel Riveline; Inna Grosheva; Aurelie Lachish-Zalait; Michael Elbaum; Alexander D Bershadsky
Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.
Molecular biology of the cell 1999;10(10):3097-112.
1999: M Selvakumar; David M Helfman
Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNA.
RNA (New York, N.Y.) 1999;5(3):378-94.
1999: C D Chen; Ryuji Kobayashi; David M Helfman
Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene.
Genes & development 1999;13(5):593-606.
1999: C D Chen; David M Helfman
Donor site competition is involved in the regulation of alternative splicing of the rat beta-tropomyosin pre-mRNA.
RNA (New York, N.Y.) 1999;5(2):290-301.
1999: David M Helfman; Christine BERTHIER; J Grossman; M Leu; Elisabeth Ehler; Evelyne Perriard; Stephan Keller
Nonmuscle tropomyosin-4 requires coexpression with other low molecular weight isoforms for binding to thin filaments in cardiomyocytes.
Journal of cell science 1999;112 ( Pt 3)():371-80.
1999: Stefan Stamm; Diana Casper; V Hanson; David M Helfman
Regulation of the neuron-specific exon of clathrin light chain B.
Brain research. Molecular brain research 1999;64(1):108-18.
1999: H Lou; David M Helfman; Robert Gagel; Susan M Berget
Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon.
Molecular and cellular biology 1999;19(1):78-85.
1998: J S Grossman; M I Meyer; Y C Wang; G J Mulligan; Ryuji Kobayashi; David M Helfman
The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points.
RNA (New York, N.Y.) 1998;4(6):613-25.
1998: Constance J Temm-Grove; B M Jockusch; Ron P Weinberger; Galina Schevzov; David M Helfman
Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesions.
Cell motility and the cytoskeleton 1998;40(4):393-407.
1997: M Gimona; Zeev Lando; Y Dolginov; J Vandekerckhove; R Kobayashi; Apolinary Sobieszek; David M Helfman
Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins.
Journal of cell science 1997;110 ( Pt 5)():611-21.
1997: Daniel Auerbach; B Rothen-Ruthishauser; S Bantle; M Leu; Elisabeth Ehler; David M Helfman; Stephan Keller
Molecular mechanisms of myofibril assembly in heart.
Cell structure and function 1997;22(1):139-46.
1997: Galina Schevzov; Peter W Gunning; Peter L Jeffrey; Constance J Temm-Grove; David M Helfman; Jim J-C Lin; Ron P Weinberger
Tropomyosin localization reveals distinct populations of microfilaments in neurites and growth cones.
Molecular and cellular neurosciences 1997;8(6):439-54.
1996: Mario Gimona; J A Kazzaz; David M Helfman
Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9618-23.
1996: Akiya Watakabe; Ryuji Kobayashi; David M Helfman
N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin.
Journal of cell science 1996;109 ( Pt 9)():2299-310.
1996: C J Temm-Grove; W Guo; David M Helfman
Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions.
Cell motility and the cytoskeleton 1996;33(3):223-40.
1995: Mario Gimona; Akiya Watakabe; David M Helfman
Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9776-80.
1995: Mark F Pittenger; A Kistler; David M Helfman
Alternatively spliced exons of the beta tropomyosin gene exhibit different affinities for F-actin and effects with nonmuscle caldesmon.
Journal of cell science 1995;108 ( Pt 10)():3253-65.
1994: Trina A Schroer; EA Fyrberg; John A Cooper; R H Waterston; David M Helfman; Thomas D Pollard; D I Meyer
Actin-related protein nomenclature and classification.
The Journal of cell biology 1994;127(6 Pt 2):1777-8.
1994: Javier F Cáceres; Stefan Stamm; David M Helfman; Adrian R Krainer
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.
Science (New York, N.Y.) 1994;265(5179):1706-9.
1994: L Balvay; A M Pret; D Libri; David M Helfman; M Y Fiszman
Splicing of the alternative exons of the chicken, rat, and Xenopus beta tropomyosin transcripts requires class-specific elements.
The Journal of biological chemistry 1994;269(31):19675-8.
1994: T Tsukahara; C Casciato; David M Helfman
Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6.
Nucleic acids research 1994;22(12):2318-25.
1994: Stefan Stamm; Michael Q Zhang; Tom Marr; David M Helfman
A sequence compilation and comparison of exons that are alternatively spliced in neurons.
Nucleic acids research 1994;22(9):1515-26.
1994: Mark F Pittenger; J A Kazzaz; David M Helfman
Functional properties of non-muscle tropomyosin isoforms.
Current opinion in cell biology 1994;6(1):96-104.
1994: Stefan Stamm; G J Mulligan; Adrian R Krainer; David M Helfman
Non-radioactive detection of m3G capped RNAs by immunoblotting.
Nucleic acids research 1994;22(2):252-3.
1994: David M Helfman
The generation of protein isoform diversity by alternative RNA splicing.
Society of General Physiologists series 1994;49():105-15.
1993: Stefan Stamm; Diana Casper; J P Lees-Miller; David M Helfman
Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9857-61.
1993: W Guo; David M Helfman
cis-elements involved in alternative splicing in the rat beta-tropomyosin gene: the 3'-splice site of the skeletal muscle exon 7 is the major site of blockage in nonmuscle cells.
Nucleic acids research 1993;21(20):4762-8.
1993: A Mayeda; David M Helfman; Adrian R Krainer
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.
Molecular and cellular biology 1993;13(5):2993-3001.
1993: R E Novy; L F Liu; C S Lin; David M Helfman; Jim J-C Lin
Expression of smooth muscle and nonmuscle tropomyosins in Escherichia coli and characterization of bacterially produced tropomyosins.
Biochimica et biophysica acta 1993;1162(3):255-65.
1992: G J Mulligan; W Guo; Steven Wormsley; David M Helfman
Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.
The Journal of biological chemistry 1992;267(35):25480-7.
1992: Mohan K Balasubramanian; David M Helfman; Sean Hemmingsen
A new tropomyosin essential for cytokinesis in the fission yeast S. pombe.
Nature 1992;360(6399):84-7.
1992: Stefan Stamm; Diana Casper; J Dinsmore; C A Kaufmann; Jürgen Brosius; David M Helfman
Clathrin light chain B: gene structure and neuron-specific splicing.
Nucleic acids research 1992;20(19):5097-103.
1992: J P Lees-Miller; David M Helfman; T A Schroer
A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility.
Nature 1992;359(6392):244-6.
1992: Mark F Pittenger; David M Helfman
In vitro and in vivo characterization of four fibroblast tropomyosins produced in bacteria: TM-2, TM-3, TM-5a, and TM-5b are co-localized in interphase fibroblasts.
The Journal of cell biology 1992;118(4):841-58.
1992: J P Lees-Miller; G Henry; David M Helfman
Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):80-3.
1991: W Guo; G J Mulligan; Steven Wormsley; David M Helfman
Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells.
Genes & development 1991;5(11):2096-107.
1991: J P Lees-Miller; David M Helfman
The molecular basis for tropomyosin isoform diversity.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(9):429-37.
1991: L O Goodwin; J P Lees-Miller; M A Leonard; S B Cheley; David M Helfman
Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters.
The Journal of biological chemistry 1991;266(13):8408-15.
1990: J P Lees-Miller; A Yan; David M Helfman
Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4.
Journal of molecular biology 1990;213(3):399-405.
1990: J P Lees-Miller; L O Goodwin; David M Helfman
Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing.
Molecular and cellular biology 1990;10(4):1729-42.
1990: David M Helfman; R F Roscigno; G J Mulligan; L A Finn; K S Weber
Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA.
Genes & development 1990;4(1):98-110.
1989: David M Helfman; W M Ricci
Branch point selection in alternative splicing of tropomyosin pre-mRNAs.
Nucleic acids research 1989;17(14):5633-50.
1988: David M Helfman; W M Ricci; L A Finn
Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.
Genes & development 1988;2(12A):1627-38.
1988: C L Roush; P J Kennelly; moira glaccum; David M Helfman; John D Scott; Edwin G Krebs
Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution.
The Journal of biological chemistry 1988;263(21):10510-6.
1988: susan erster; L A Finn; D A Frendewey; David M Helfman
Use of RNase H and primer extension to analyze RNA splicing.
Nucleic acids research 1988;16(13):5999-6014.
1987: Y Yamawaki-Kataoka; David M Helfman
Isolation and characterization of cDNA clones encoding a low molecular weight nonmuscle tropomyosin isoform.
The Journal of biological chemistry 1987;262(22):10791-800.
1987: John D Scott; moira glaccum; M J Zoller; Michael D Uhler; David M Helfman; G S McKnight; Edwin G Krebs
The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(15):5192-6.
1987: David M Helfman; S H Hughes
Use of antibodies to screen cDNA expression libraries prepared in plasmid vectors.
Methods in enzymology 1987;152():451-7.
1987: David M Helfman; J C Fiddes; Douglas Hanahan
Directional cDNA cloning in plasmid vectors by sequential addition of oligonucleotide linkers.
Methods in enzymology 1987;152():349-59.
1986: David M Helfman; S Cheley; E Kuismanen; L A Finn; Y Yamawaki-Kataoka
Nonmuscle and muscle tropomyosin isoforms are expressed from a single gene by alternative RNA splicing and polyadenylation.
Molecular and cellular biology 1986;6(11):3582-95.
1985: Y Yamawaki-Kataoka; David M Helfman
Rat embryonic fibroblast tropomyosin 1. cDNA and complete primary amino acid sequence.
The Journal of biological chemistry 1985;260(27):14440-5.
1985: Maria Grazia Catelli; Nadine Binart; J R Feramisco; David M Helfman
Cloning of the chick hsp 90 cDNA in expression vector.
Nucleic acids research 1985;13(17):6035-47.
1985: Connie S Birkenmeier; D M Bodine; E A Repasky; David M Helfman; S H Hughes; Jane E Barker
Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5671-5.
1985: E Harlow; N M Williamson; R Ralston; David M Helfman; T E Adams
Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.
Molecular and cellular biology 1985;5(7):1601-10.
1985: J J Lin; David M Helfman; S H Hughes; C S Chou
Tropomyosin isoforms in chicken embryo fibroblasts: purification, characterization, and changes in Rous sarcoma virus-transformed cells.
The Journal of cell biology 1985;100(3):692-703.
1984: David M Helfman; J R Feramisco; W M Ricci; S H Hughes
Isolation and sequence of a cDNA clone that contains the entire coding region for chicken smooth-muscle alpha-tropomyosin.
The Journal of biological chemistry 1984;259(22):14136-43.
1984: David M Helfman; N Katoh; J F Kuo
Purification and properties of cyclic CMP phosphodiesterase.
Advances in cyclic nucleotide and protein phosphorylation research 1984;16():403-16.
1983: Markku T Kurkinen; D P Barlow; David M Helfman; J G Williams; B L Hogan
Isolation of cDNA clones for basal lamina components: type IV procollagen.
Nucleic acids research 1983;11(18):6199-209.
1983: David M Helfman; K C Barnes; J M Kinkade; W R Vogler; M Shoji; J F Kuo
Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid.
Cancer research 1983;43(6):2955-61.
1983: David M Helfman; B D Appelbaum; W R Vogler; J F Kuo
Phospholipid-sensitive Ca2+-dependent protein kinase and its substrates in human neutrophils.
Biochemical and biophysical research communications 1983;111(3):847-53.
1983: David M Helfman; J R Feramisco; J C Fiddes; G P Thomas; S H Hughes
Identification of clones that encode chicken tropomyosin by direct immunological screening of a cDNA expression library.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(1):31-5.
1982: J R Feramisco; J E Smart; Keith Burridge; David M Helfman; G P Thomas
Co-existence of vinculin and a vinculin-like protein of higher molecular weight in smooth muscle.
The Journal of biological chemistry 1982;257(18):11024-31.
1982: David M Helfman; J F Kuo
A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
The Journal of biological chemistry 1982;257(2):1044-7.
1982: N Katoh; R L Raynor; B C Wise; R C Schatzman; Raymond Scott Turner; David M Helfman; J N Fain; J F Kuo
Inhibition by melittin of phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinases.
The Biochemical journal 1982;202(1):217-24.
1982: N Katoh; David M Helfman; R W Wrenn; J F Kuo
Differential regulation of calcium-dependent and calcium-independent cyclic nucleotide phosphodiesterases from heart by palmitoylcarnitine and palmitoyl coenzyme A.
Biochimica et biophysica acta 1982;714(1):129-35.
1982: David M Helfman; J F Kuo
Differential effects of various phosphodiesterase inhibitors, pyrimidine and purine compounds, and inorganic phosphates on cyclic CMP, cyclic AMP and cyclic GMP phosphodiesterases.
Biochemical pharmacology 1982;31(1):43-7.
1981: David M Helfman; M Shoji; J F Kuo
Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
The Journal of biological chemistry 1981;256(12):6327-34.
1978: J F Kuo; M Shoji; Nancy L Brackett; David M Helfman
Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases.
Journal of cyclic nucleotide research 1978;4(6):463-74.
1978: David M Helfman; Nancy L Brackett; J F Kuo
Depression of cytidine 3':5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(9):4422-5.
1978: M Shoji; Nancy L Brackett; David M Helfman; H P Morris; J F Kuo
Decreased activity of cytidine 3':5'-monophosphate (cyclic CMP) phosphodiesterase in the fast-growing Morris hepatoma 3924A, but not in the slow-growing Morris hepatoma 9618A.
Biochemical and biophysical research communications 1978;83(3):1140-6.
1978: R M Zucker; David M Helfman; A M Tershakovec
Thymus cell variations in AKR leukemia.
American journal of veterinary research 1978;39(1):145-9.
1978: J F Kuo; Nancy L Brackett; J W Stubbs; M Shoji; David M Helfman
Involvements of cyclic nucleotide systems in enlarged mice lungs produced by butylated hydroxytoluene.
Biochemical pharmacology 1978;27(12):1671-5.
1976: R M Zucker; David M Helfman
Electronic volume analysis of L1210 chemotherapy.
Cancer research 1976;36(12):4434-8.
1976: R M Zucker; David M Helfman
Thymus subpopulations: density gradients and volume distributions studies.
Cellular immunology 1976;22(1):43-52.