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Miep Helfrich

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Anatomy

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Astrid D Bakker; Richard M Aspden; Carmen Huesa; Alun Hughes; Jenneke Klein-Nulend; Rob J van't Hof; Miep H Helfrich
Endothelial nitric oxide synthase is not essential for nitric oxide production by osteoblasts subjected to fluid shear stress in vitro.
Lynne J Hocking; Caroline Whitehouse; Miep H Helfrich
Autophagy: a new player in skeletal maintenance?
Alessandra Pangrazio; Claire Schlack; Ansgar Schulz; D Strina; Ashok Vellodi; Paul Veys; Paolo Vezzoni; Anna Villa; Luca Zammataro; Barbara Cassani; Robert Chiesa; Julie Crockett; Anne Durandy; Angela Duthie; Alain Fischer; Matteo M Guerrini; Miep H Helfrich; Uwe Kornak; Nadia Lo Iacono; Veronica Marrella; David J Mellis; Despina Moshous; Cristina Sobacchi
RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations.

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All Publications

2013: Astrid D Bakker; Richard M Aspden; Carmen Huesa; Alun Hughes; Jenneke Klein-Nulend; Rob J van't Hof; Miep H Helfrich
Endothelial nitric oxide synthase is not essential for nitric oxide production by osteoblasts subjected to fluid shear stress in vitro.
Calcified tissue international 2013;92(3):228-39.
2012: Lynne J Hocking; Caroline Whitehouse; Miep H Helfrich
Autophagy: a new player in skeletal maintenance?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(7):1439-47.
2012: Alessandra Pangrazio; Claire Schlack; Ansgar Schulz; D Strina; Ashok Vellodi; Paul Veys; Paolo Vezzoni; Anna Villa; Luca Zammataro; Barbara Cassani; Robert Chiesa; Julie Crockett; Anne Durandy; Angela Duthie; Alain Fischer; Matteo M Guerrini; Miep H Helfrich; Uwe Kornak; Nadia Lo Iacono; Veronica Marrella; David J Mellis; Despina Moshous; Cristina Sobacchi
RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(2):342-51.
2012: Alun Hughes; Jennifer Kleine-Albers; Stuart H Ralston; Miep H Helfrich; Michael J Rogers
A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro.
Calcified tissue international 2012;90(2):151-62.
2011: David J Mellis; Miep H Helfrich; Cecile Itzstein; Julie C Crockett
The skeleton: a multi-functional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorption.
The Journal of endocrinology 2011;211(2):131-43.
2011: Julie Crockett; Angela Duthie; John Greenhorn; Miep H Helfrich; David J Mellis; Stuart H Ralston; Kathleen Ij Shennan; Debbie I Wilkinson; Michael J Rogers
Signal peptide mutations in RANK prevent downstream activation of NF-κB.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(8):1926-38.
2011: Julie C Crockett; Michael J Rogers; Fraser P Coxon; Lynne J Hocking; Miep H Helfrich
Bone remodelling at a glance.
Journal of cell science 2011;124(Pt 7):991-8.
2011: Julie Crockett; D J Mellis; D I Scott; Miep H Helfrich
New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2011;22(1):1-20.
2010: Lynne J Hocking; David J Mellis; Paul S McCabe; Miep H Helfrich; Michael J Rogers
Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts.
Biochemical and biophysical research communications 2010;402(3):543-8.
2010: Carmen Huesa; Miep H Helfrich; Richard M Aspden
Parallel-plate fluid flow systems for bone cell stimulation.
Journal of biomechanics 2010;43(6):1182-9.
2010: Eliane Chouery; Alessandra Pangrazio; Annalisa Frattini; Anna Villa; Liesbeth Van Wesenbeeck; Elke Piters; Wim Van Hul; Fraser Coxon; Tabitha Schouten; Miep H Helfrich; Gérard Lefranc; André Mégarbané
A new familial sclerosing bone dysplasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(3):676-80.
2009: Vincent Everts; Teun J de Vries; Miep H Helfrich
Osteoclast heterogeneity: lessons from osteopetrosis and inflammatory conditions.
Biochimica et biophysica acta 2009;1792(8):757-65.
2008: Matteo M Guerrini; Cristina Sobacchi; Barbara Cassani; Mario Abinun; Sara S Kilic; Alessandra Pangrazio; Daniele Moratto; Evelina Mazzolari; Jill Clayton-Smith; Paul Orchard; Fraser Coxon; Miep H Helfrich; Julie Crockett; David Mellis; Ashok Vellodi; Ilhan Tezcan; Luigi D Notarangelo; Michael J Rogers; Paolo Vezzoni; Anna Villa; Annalisa Frattini
Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations.
American journal of human genetics 2008;83(1):64-76.
2008: Miep H Helfrich; Lynne J Hocking
Genetics and aetiology of Pagetic disorders of bone.
Archives of biochemistry and biophysics 2008;473(2):172-82.
2008: Andrea Del Fattore; Rachele Fornari; Liesbeth Van Wesenbeeck; Fenna de Freitas; Jean-Pierre Timmermans; Barbara Peruzzi; Alfredo Cappariello; Nadia Rucci; Giovanni Spera; Miep H Helfrich; Wim Van Hul; Silvia Migliaccio; Anna Teti
A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(3):380-91.
2007: Cristina Sobacchi; Annalisa Frattini; Matteo M Guerrini; Mario Abinun; Alessandra Pangrazio; Lucia Susani; R G M Bredius; Grazia Mancini; Andrew Cant; Nick Bishop; Peter Stanislaw Grabowski; Andrea Del Fattore; Chiara Messina; Gabriella Errigo; Fraser Coxon; Debbie I Scott; Anna Teti; Michael J Rogers; Paolo Vezzoni; Anna Villa; Miep H Helfrich
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.
Nature genetics 2007;39(8):960-2.
2007: Liesbeth Van Wesenbeeck; Paul R Odgren; Fraser Coxon; Annalisa Frattini; Pierre Moens; Bram Perdu; Carole A MacKay; Els Van Hul; Jean-Pierre Timmermans; Filip Vanhoenacker; Ruben Jacobs; Barbara Peruzzi; Anna Teti; Miep H Helfrich; Michael J Rogers; Anna Villa; Wim Van Hul
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.
The Journal of clinical investigation 2007;117(4):919-30.
2007: Stuart H Ralston; Muhammad A Afzal; Miep H Helfrich; William D Fraser; James A Gallagher; Andrew Mee; Bertus K Rima
Multicenter blinded analysis of RT-PCR detection methods for paramyxoviruses in relation to Paget's disease of bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(4):569-77.
2005: Miep H Helfrich
Osteoclast diseases and dental abnormalities.
Archives of oral biology 2005;50(2):115-22.
2004: Robert J van't Hof; Jeny Macphee; Helene Libouban; Miep H Helfrich; Stuart H Ralston
Regulation of bone mass and bone turnover by neuronal nitric oxide synthase.
Endocrinology 2004;145(11):5068-74.
2003: Miep H Helfrich
Osteoclast diseases.
Microscopy research and technique 2003;61(6):514-32.
2003: Neil W A McGowan; Heather MacPherson; Katrien Janssens; Wim Van Hul; Julie Crockett; William D Fraser; Stuart H Ralston; Miep H Helfrich
A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro.
The Journal of clinical endocrinology and metabolism 2003;88(7):3321-6.
2003: Deborah Marshall; Miep H Helfrich; Richard M Aspden
Scanning electron microscopy of bone.
Methods in molecular medicine 2003;80():311-20.
2002: Bertus K Rima; Uta Gassen; Miep H Helfrich; Stuart H Ralston
The pro and con of measles virus in Paget's disease: con.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(12):2290-2; author reply 2293.
2002: Sharon Gordon; Miep H Helfrich; Hamdi I A Sati; Mike Greaves; Stuart H Ralston; Dominic J Culligan; Richard L Soutar; Michael J Rogers
Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma.
British journal of haematology 2002;119(2):475-83.
2001: Fraser Coxon; Miep H Helfrich; B Larijani; Mariusz Muzylak; James E Dunford; Deborah Marshall; Alastair D McKinnon; S A Nesbitt; Michael A Horton; Miguel C Seabra; Frank H Ebetino; Michael J Rogers
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
The Journal of biological chemistry 2001;276(51):48213-22.
2001: Helena L Benford; Neil W A McGowan; Miep H Helfrich; M E Nuttall; Michael J Rogers
Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro.
Bone 2001;28(5):465-73.
2001: Neil W A McGowan; E J Walker; Heather MacPherson; Stuart H Ralston; Miep H Helfrich
Cytokine-activated endothelium recruits osteoclast precursors.
Endocrinology 2001;142(4):1678-81.
2001: Katharine E Armour; Kenneth J Armour; M E Gallagher; A Gödecke; Miep H Helfrich; David M Reid; Stuart H Ralston
Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase.
Endocrinology 2001;142(2):760-6.
2001: Miep H Helfrich; E J Gerritsen
Formation of non-resorbing osteoclasts from peripheral blood mononuclear cells of patients with malignant juvenile osteopetrosis.
British journal of haematology 2001;112(1):64-8.
2000: Miep H Helfrich; Richard P Hobson; Peter Stanislaw Grabowski; A Zurbriggen; S L Cosby; G R Dickson; William D Fraser; C G Ooi; P L Selby; A J Crisp; R G Wallace; S Kahn; Stuart H Ralston
A negative search for a paramyxoviral etiology of Paget's disease of bone: molecular, immunological, and ultrastructural studies in UK patients.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(12):2315-29.
2000: SA Chappell; John Le Quesne; FE Paulin; Matthew deschoolmeester; Mark Stoneley; Richard L Soutar; S H Ralston; Miep H Helfrich; Anne E Willis
A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation.
Oncogene 2000;19(38):4437-40.
2000: Fraser Coxon; Miep H Helfrich; Robert J van't Hof; S Sebti; Stuart H Ralston; A Hamilton; Michael J Rogers
Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(8):1467-76.
1999: Stuart H Ralston; Miep H Helfrich
Are paramyxoviruses involved in Paget's disease? A negative view.
Bone 1999;24(5 Suppl):17S-18S.
1998: Jenneke Klein-Nulend; Miep H Helfrich; J G H Sterck; Heather MacPherson; Manon Joldersma; S H Ralston; Cornelis M Semeins; Elisabeth H Burger
Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent.
Biochemical and biophysical research communications 1998;250(1):108-14.
1997: Miep H Helfrich; D E Evans; Peter Stanislaw Grabowski; Jennifer Pollock; H Ohshima; Stuart H Ralston
Expression of nitric oxide synthase isoforms in bone and bone cell cultures.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(7):1108-15.
1997: Peter Stanislaw Grabowski; P K Wright; R J Van 't Hof; Miep H Helfrich; H Ohshima; Stuart H Ralston
Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis.
British journal of rheumatology 1997;36(6):651-5.
1997: Stuart H Ralston; Richard P Hobson; T H Pennington; Miep H Helfrich
Does Paget's disease really have a viral aetiology?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(5):863-5.
1997: Miep H Helfrich; E Livingston; I M Franklin; Richard L Soutar
Expression of adhesion molecules in malignant plasma cells in multiple myeloma: comparison with normal plasma cells and functional significance.
Blood reviews 1997;11(1):28-38.
1996: Miep H Helfrich; S A Nesbitt; Päivi Lakkakorpi; M J Barnes; S C Bodary; G Shankar; W T Mason; D L Mendrick; H K Väänänen; M A Horton
Beta 1 integrins and osteoclast function: involvement in collagen recognition and bone resorption.
Bone 1996;19(4):317-28.
1996: J H Fraser; Miep H Helfrich; H M Wallace; Stuart H Ralston
Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae.
Bone 1996;19(3):223-6.
1995: Stuart H Ralston; L P Ho; Miep H Helfrich; Peter Stanislaw Grabowski; P W Johnston; Nigel Benjamin
Nitric oxide: a cytokine-induced regulator of bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(7):1040-9.
1994: M A Horton; J H Spragg; S C Bodary; Miep H Helfrich
Recognition of cryptic sites in human and mouse laminins by rat osteoclasts is mediated by beta 3 and beta 1 integrins.
Bone 1994;15(6):639-46.
1994: Stuart H Ralston; D Todd; Miep H Helfrich; Nigel Benjamin; Peter Stanislaw Grabowski
Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase.
Endocrinology 1994;135(1):330-6.
1993: G Shankar; I Davison; Miep H Helfrich; W T Mason; M A Horton
Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts.
Journal of cell science 1993;105 ( Pt 1)():61-8.
1993: Päivi Lakkakorpi; Miep H Helfrich; M A Horton; H K Väänänen
Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy.
Journal of cell science 1993;104 ( Pt 3)():663-70.
1993: M A Horton; E L Dorey; S A Nesbitt; James Samanen; FE Ali; JM Stadel; A Nichols; R Greig; Miep H Helfrich
Modulation of vitronectin receptor-mediated osteoclast adhesion by Arg-Gly-Asp peptide analogs: a structure-function analysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(2):239-47.
1992: A M Flanagan; M A Horton; E L Dorey; D A Collins; R S Evely; Jane M Moseley; F C Firkin; Timothy J Chambers; Miep H Helfrich; T John Martin
An assessment of the ability of human bone marrow cultures to generate osteoclasts.
International journal of experimental pathology 1992;73(3):387-401.
1992: Miep H Helfrich; S A Nesbitt; M A Horton
Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(3):345-51.
1992: Miep H Helfrich; S A Nesbitt; E L Dorey; M A Horton
Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a beta 3 integrin.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(3):335-43.
1991: John FRancis Marshall; S A Nesbitt; Miep H Helfrich; M A Horton; K Polakova; I R Hart
Integrin expression in human melanoma cell lines: heterogeneity of vitronectin receptor composition and function.
International journal of cancer. Journal international du cancer 1991;49(6):924-31.
1991: Päivi Lakkakorpi; M A Horton; Miep H Helfrich; E K Karhukorpi; H K Väänänen
Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface.
The Journal of cell biology 1991;115(4):1179-86.
1991: M A Horton; M L Taylor; Timothy R Arnett; Miep H Helfrich
Arg-Gly-Asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts.
Experimental cell research 1991;195(2):368-75.