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Kristian Helin

Research Profile

Chemicals & Drugs

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Mouse

Physiology

Anatomy

Cell Line

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Methylation

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Mareike Albert; Iratxe Abarrategui; Jens V Johansen; Susanne M Kooistra; Martina Malatesta; Cristina Morales Torres; Jens C Rekling; Sandra U Schmitz; Kristian Helin
The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3.
Xudong Wu; Jens Vilstrup Johansen; Kristian Helin
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Pietro Vella; Kristine Williams; Alessandra Roberto; Andrea Scelfo; Tiziana Bonaldi; Fulvio Chiacchiera; Jesper Christensen; Alessandro Cuomo; Kristian Helin; Sriganesh Jammula; Diego Pasini
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.

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All Publications

2013: Mareike Albert; Iratxe Abarrategui; Jens V Johansen; Susanne M Kooistra; Martina Malatesta; Cristina Morales Torres; Jens C Rekling; Sandra U Schmitz; Kristian Helin
The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3.
PLoS genetics 2013;9(4):e1003461.
2013: Xudong Wu; Jens Vilstrup Johansen; Kristian Helin
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Molecular cell 2013;49(6):1134-46.
2013: Pietro Vella; Kristine Williams; Alessandra Roberto; Andrea Scelfo; Tiziana Bonaldi; Fulvio Chiacchiera; Jesper Christensen; Alessandro Cuomo; Kristian Helin; Sriganesh Jammula; Diego Pasini
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.
Molecular cell 2013;49(4):645-56.
2013: Cristina Morales Torres; Anne Laugesen; Kristian Helin
Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells.
PloS one 2013;8(4):e60020.
2012: Line H Kristensen; Michael Lees; Anders L Nielsen; Lars Olsen; Paul Cloos; Charlotte Helgstrand; Kristian Helin; Jette S Kastrup; Michael Gajhede
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.
The FEBS journal 2012;279(11):1905-14.
2012: Susanne Marije Kooistra; Kristian Helin
Molecular mechanisms and potential functions of histone demethylases.
Nature reviews. Molecular cell biology 2012;13(5):297-311.
2012: Anders L Nielsen; Karen B Stephansen; Paul Cloos; Michael Gajhede; Charlotte Helgstrand; Kristian Helin; Jan B L Kristensen; Line H Kristensen; Michael Lees; Lars Olsen
Identification of catechols as histone-lysine demethylase inhibitors.
FEBS letters 2012;586(8):1190-4.
2012: Eva Madi Riising; Kristian Helin
A new role for the polycomb group protein Ezh1 in promoting transcription.
Molecular cell 2012;45(2):145-6.
2011: Brian Lohse; Karl Agger; Michael Gajhede; Kristian Helin; Jesper L Kristensen; Line H Kristensen; Rasmus P Clausen
Inhibitors of histone demethylases.
Bioorganic & medicinal chemistry 2011;19(12):3625-36.
2011: Heidi Rye Hudlebusch; Jens Vilstrup Johansen; Mette Jørgensen; Michael James Lees; Lisa Leth Maroun; Bodil Laub Petersen; Micaela Quarto; Catherine Rechnitzer; Rossella Rota; Eric Santoni-Rugiu; Guido Sauter; Henrik Schrøder; Ronald Simon; Julie Skotte; Zarah Glad Zimling; Maria Antonietta De Ioris; Kristian Helin
MMSET is highly expressed and associated with aggressiveness in neuroblastoma.
Cancer research 2011;71(12):4226-35.
2011: Kristine Williams; Jesper Christensen; Marianne Terndrup Pedersen; Jens V Johansen; Paul A C Cloos; Juri Rappsilber; Kristian Helin
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
Nature 2011;473(7347):343-8.
2011: Heidi Rye Hudlebusch; Eric Santoni-Rugiu; Ronald Simon; Elisabeth Ralfkiaer; Henrik Holm Rossing; Jens Vilstrup Johansen; Mette Jørgensen; Guido Sauter; Kristian Helin
The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2919-33.
2011: Stine Jørgensen; Morten Eskildsen; Kasper Fugger; Lisbeth Hansen; Marie Sofie Yoo Larsen; Arne Nedergaard Kousholt; Randi G Syljuåsen; Morten Beck Trelle; Ole N Jensen; Kristian Helin; Claus Storgaard Sørensen
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.
The Journal of cell biology 2011;192(1):43-54.
2010: Marianne Terndrup Pedersen; Kristian Helin
Histone demethylases in development and disease.
Trends in cell biology 2010;20(11):662-71.
2010: Nicolaj Strøyer Christophersen; Kristian Helin
Epigenetic control of embryonic stem cell fate.
The Journal of experimental medicine 2010;207(11):2287-95.
2010: Simmi Suman Gehani; Shuchi Agrawal-Singh; Nikolaj Dietrich; Nicolaj Strøyer Christophersen; Kristian Helin; Klaus Hansen
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.
Molecular cell 2010;39(6):886-900.
2010: Bo T Porse; Ole W Petersen; Kristian Helin
[Basic stem cell biology and cancer].
Ugeskrift for laeger 2010;172(38):2600-3.
2010: Diego Pasini; Martina Malatesta; Hye Ryung Jung; Julian Walfridsson; Anton Willer; Linda Olsson; Julie Skotte; Anton Wutz; Bo T Porse; Ole Nørregaard Jensen; Kristian Helin
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.
Nucleic acids research 2010;38(15):4958-69.
2010: Lluís Morey; Kristian Helin
Polycomb group protein-mediated repression of transcription.
Trends in biochemical sciences 2010;35(6):323-32.
2010: Daniela Kleine-Kohlbrecher; Jesper Christensen; Julien Vandamme; Iratxe Abarrategui; Mads Bak; Niels Tommerup; Xiaobing Shi; Or Gozani; Juri Rappsilber; Anna Elisabetta Salcini; Kristian Helin
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.
Molecular cell 2010;38(2):165-78.
2010: Mareike Albert; Kristian Helin
Histone methyltransferases in cancer.
Seminars in cell & developmental biology 2010;21(2):209-20.
2010: Diego Pasini; Paul A C Cloos; Julian Walfridsson; Linda Olsson; John-Paul Bukowski; Jens V Johansen; Mads Bak; Niels Tommerup; Juri Rappsilber; Kristian Helin
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.
Nature 2010;464(7286):306-10.
2010: Claus Storgaard Sørensen; Marina Melixetian; Ditte Kjaersgaard Klein; Kristian Helin
NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.
Cell cycle (Georgetown, Tex.) 2010;9(3):450-5.
2009: Marco Ciró; Elena Prosperini; Micaela Quarto; Ursula Grazini; Julian Walfridsson; Fraser McBlane; Paolo Nucifero; Giovanni Pacchiana; Maria Capra; Jesper Christensen; Kristian Helin
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.
Cancer research 2009;69(21):8491-8.
2009: Marina Melixetian; Ditte Kjaersgaard Klein; Claus Storgaard Sørensen; Kristian Helin
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
Nature cell biology 2009;11(10):1247-53.
2009: Greta Caprara; Raffaella Zamponi; Marina Melixetian; Kristian Helin
Isolation and characterization of DUSP11, a novel p53 target gene.
Journal of cellular and molecular medicine 2009;13(8B):2158-70.
2009: Karl Agger; Paul A C Cloos; Lise Rudkjaer; Kristine Williams; Gitte Andersen; Jesper Christensen; Kristian Helin
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.
Genes & development 2009;23(10):1171-6.
2009: Klaus H Hansen; Kristian Helin
Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2.
Epigenetics : official journal of the DNA Methylation Society 2009;4(3):133-8.
2009: Andrea Ballabeni; Raffaella Zamponi; Greta Caprara; Marina Melixetian; Sergio Bossi; Laura Masiero; Kristian Helin
Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.
The Journal of biological chemistry 2009;284(5):3028-36.
2009: Esther Hulleman; Micaela Quarto; Richard Vernell; Giacomo Masserdotti; Elena Colli; Johan M Kros; Daniel Levi; Paolo Gaetani; Patrizia Tunici; Gaetano Finocchiaro; Riccardo Rodriguez Y Baena; Maria Capra; Kristian Helin
A role for the transcription factor HEY1 in glioblastoma.
Journal of cellular and molecular medicine 2009;13(1):136-46.
2008: Klaus H Hansen; Adrian P Bracken; Diego Pasini; Nikolaj Dietrich; Simmi S Gehani; Astrid Monrad; Juri Rappsilber; Mads Lerdrup; Kristian Helin
A model for transmission of the H3K27me3 epigenetic mark.
Nature cell biology 2008;10(11):1291-300.
2008: Diego Pasini; Klaus H Hansen; Jesper Christensen; Karl Agger; Paul Cloos; Kristian Helin
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
Genes & development 2008;22(10):1345-55.
2008: Paul Cloos; Jesper Christensen; Karl Agger; Kristian Helin
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
Genes & development 2008;22(9):1115-40.
2008: Karl Agger; Jesper Christensen; Paul Cloos; Kristian Helin
The emerging functions of histone demethylases.
Current opinion in genetics & development 2008;18(2):159-68.
2008: Diego Pasini; Adrian P Bracken; Karl Agger; Jesper Christensen; K Hansen; P A C Cloos; Kristian Helin
Regulation of stem cell differentiation by histone methyltransferases and demethylases.
Cold Spring Harbor symposia on quantitative biology 2008;73():253-63.
2008: Eva Madi Riising; Roberto Boggio; Susanna Chiocca; Kristian Helin; Diego Pasini
The polycomb repressive complex 2 is a potential target of SUMO modifications.
PloS one 2008;3(7):e2704.
2007: Stine Jørgensen; Ingegerd Elvers; Morten Beck Trelle; Tobias Menzel; Morten Eskildsen; Ole N Jensen; Thomas Helleday; Kristian Helin; Claus Storgaard Sørensen
The histone methyltransferase SET8 is required for S-phase progression.
The Journal of cell biology 2007;179(7):1337-45.
2007: Ana Gutierrez del Arroyo; Selma El Messaoudi; Paula A Clark; Marion James; Francesca Stott; Adrian P Bracken; Kristian Helin; Gordon Peters
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells.
Cell cycle (Georgetown, Tex.) 2007;6(21):2697-705.
2007: Karl Agger; Paul Cloos; Jesper Christensen; Diego Pasini; Simon Rose; Juri Rappsilber; Irina Issaeva; Eli Canaani; Anna Elisabetta Salcini; Kristian Helin
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Nature 2007;449(7163):731-4.
2007: Raffaella Villa; Diego Pasini; Arantxa Gutierrez; Lluis Morey; Manuela Occhionorelli; Emmanuelle Viré; Josep F Nomdedeu; Thomas Jenuwein; Pier Giuseppe Pelicci; Saverio Minucci; François Fuks; Kristian Helin; Luciano Di Croce
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.
Cancer cell 2007;11(6):513-25.
2007: Diego Pasini; Adrian P Bracken; Jacob B Hansen; Manuela Capillo; Kristian Helin
The polycomb group protein Suz12 is required for embryonic stem cell differentiation.
Molecular and cellular biology 2007;27(10):3769-79.
2007: Jesper Christensen; Karl Agger; Paul Cloos; Diego Pasini; Simon Rose; Lau Sennels; Juri Rappsilber; Klaus H Hansen; Anna Elisabetta Salcini; Kristian Helin
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Cell 2007;128(6):1063-76.
2007: Nikolaj Dietrich; Adrian P Bracken; Emmanuelle Trinh; Charlotte K Schjerling; Haruhiko Koseki; Juri Rappsilber; Kristian Helin; Klaus H Hansen
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.
The EMBO journal 2007;26(6):1637-48.
2007: Adrian P Bracken; Daniela Kleine-Kohlbrecher; Nikolaj Dietrich; Diego Pasini; GAETANO GARGIULO; Chantal Beekman; Kim Theilgaard-Mönch; Saverio Minucci; Bo T Porse; Jean-Christophe Marine; Klaus H Hansen; Kristian Helin
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Genes & development 2007;21(5):525-30.
2007: Huan Qiao; Luisa Di Stefano; Chan Tian; Yun-Yan Li; Yan-Hui Yin; Xiao-Ping Qian; Xue-Wen Pang; Yan Li; Michael Allen McNutt; Kristian Helin; Yu Zhang; Wei-Feng Chen
Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F.
The Journal of biological chemistry 2007;282(1):454-66.
2006: Paul Cloos; Jesper Christensen; Karl Agger; Alessio Maiolica; Juri Rappsilber; Torben Antal; Klaus H Hansen; Kristian Helin
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Nature 2006;442(7100):307-11.
2006: Adrian P Bracken; Nikolaj Dietrich; Diego Pasini; Klaus H Hansen; Kristian Helin
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.
Genes & development 2006;20(9):1123-36.
2005: Sovana Adhikary; Federica Marinoni; Andreas Hock; Esther Hulleman; Nikita Popov; Rudi Beier; Sandra Bernard; Micaela Quarto; Maria Capra; Stephan Goettig; Ulrike Kogel; Martin Scheffner; Kristian Helin; Martin Eilers
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.
Cell 2005;123(3):409-21.
2005: Emanuela Colombo; Paola Bonetti; eros lazzerini denchi; Paola Martinelli; Raffaella Zamponi; Jean-Christophe Marine; Kristian Helin; Brunangelo Falini; Pier Giuseppe Pelicci
Nucleophosmin is required for DNA integrity and p19Arf protein stability.
Molecular and cellular biology 2005;25(20):8874-86.
2005: eros lazzerini denchi; Kristian Helin
E2F1 is crucial for E2F-dependent apoptosis.
EMBO reports 2005;6(7):661-8.
2005: eros lazzerini denchi; Claire Attwooll; Diego Pasini; Kristian Helin
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland.
Molecular and cellular biology 2005;25(7):2660-72.
2005: Karl Agger; Eric Santoni-Rugiu; Christian Holmberg; Olle Karlström; Kristian Helin
Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS.
Oncogene 2005;24(5):780-9.
2005: Claire Attwooll; Sergio Oddi; Peter Cartwright; Elena Prosperini; Karl Agger; Peter Steensgaard; Christian Wagener; Claude Sardet; M Cristina Moroni; Kristian Helin
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
The Journal of biological chemistry 2005;280(2):1199-208.
2005: Jesper Christensen; Paul Cloos; Ulla Toftegaard; David Klinkenberg; Adrian P Bracken; Emmanuelle Trinh; Mel Heeran; Luisa Di Stefano; Kristian Helin
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Nucleic acids research 2005;33(17):5458-70.
2005: Esther Hulleman; Kristian Helin
Molecular mechanisms in gliomagenesis.
Advances in cancer research 2005;94():1-27.
2004: Claire Attwooll; eros lazzerini denchi; Kristian Helin
The E2F family: specific functions and overlapping interests.
The EMBO journal 2004;23(24):4709-16.
2004: Diego Pasini; Adrian P Bracken; Michael Rugaard Jensen; eros lazzerini denchi; Kristian Helin
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
The EMBO journal 2004;23(20):4061-71.
2004: Andrea Ballabeni; Marina Melixetian; Raffaella Zamponi; Laura Masiero; Federica Marinoni; Kristian Helin
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.
The EMBO journal 2004;23(15):3122-32.
2004: Adrian P Bracken; Marco Ciro; Andrea Cocito; Kristian Helin
E2F target genes: unraveling the biology.
Trends in biochemical sciences 2004;29(8):409-17.
2004: Marina Melixetian; Kristian Helin
Geminin: a major DNA replication safeguard in higher eukaryotes.
Cell cycle (Georgetown, Tex.) 2004;3(8):1002-4.
2004: Davide Danovi; Erik Meulmeester; Diego Pasini; Domenico Migliorini; Maria Capra; Ruth Frenk; Petra de Graaf; Sarah Francoz; Patrizia Gasparini; Alberto Gobbi; Kristian Helin; Pier Giuseppe Pelicci; Aart G Jochemsen; Jean-Christophe Marine
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.
Molecular and cellular biology 2004;24(13):5835-43.
2004: Emmanuelle Trinh; eros lazzerini denchi; Kristian Helin
Naturally death-resistant precursor cells revealed as the origin of retinoblastoma.
Cancer cell 2004;5(6):513-5.
2004: Marina Melixetian; Andrea Ballabeni; Laura Masiero; Patrizia Gasparini; Raffaella Zamponi; Jiri Bartek; Jiri Lukas; Kristian Helin
Loss of Geminin induces rereplication in the presence of functional p53.
The Journal of cell biology 2004;165(4):473-82.
2004: Emanuela Grassilli; Andrea Ballabeni; Emilia Maellaro; Barbara Del Bello; Kristian Helin
Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways.
The Journal of biological chemistry 2004;279(20):21318-26.
2004: Diego Pasini; Adrian P Bracken; Kristian Helin
Polycomb group proteins in cell cycle progression and cancer.
Cell cycle (Georgetown, Tex.) 2004;3(4):396-400.
2004: Michael Rugaard Jensen; Kristian Helin
OVCA1: emerging as a bona fide tumor suppressor.
Genes & development 2004;18(3):245-8.
2003: Luisa Di Stefano; Michael Rugaard Jensen; Kristian Helin
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes.
The EMBO journal 2003;22(23):6289-98.
2003: Richard Vernell; Kristian Helin; Heiko Müller
Identification of target genes of the p16INK4A-pRB-E2F pathway.
The Journal of biological chemistry 2003;278(46):46124-37.
2003: Adrian P Bracken; Diego Pasini; Maria Capra; Elena Prosperini; Elena Colli; Kristian Helin
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
The EMBO journal 2003;22(20):5323-35.
2003: Michael Rugaard Jensen; Valentina M Factor; A Fantozzi; Kristian Helin; Chang-Goo Huh; Snorri S Thorgeirsson
Reduced hepatic tumor incidence in cyclin G1-deficient mice.
Hepatology (Baltimore, Md.) 2003;37(4):862-70.
2003: Guang Gao; Adrian P Bracken; Karina Burkard; Diego Pasini; Marie Classon; Claire Attwooll; Masashi Sagara; Takashi Imai; Kristian Helin; Jiyong Zhao
NPAT expression is regulated by E2F and is essential for cell cycle progression.
Molecular and cellular biology 2003;23(8):2821-33.
2003: Marco Ciro; Adrian P Bracken; Kristian Helin
Profiling cancer.
Current opinion in cell biology 2003;15(2):213-20.
2002: Domenico Migliorini; eros lazzerini denchi; Davide Danovi; Aart G Jochemsen; Manuela Capillo; Alberto Gobbi; Kristian Helin; Pier Giuseppe Pelicci; Jean-Christophe Marine
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.
Molecular and cellular biology 2002;22(15):5527-38.
2002: Marina Lomazzi; M Cristina Moroni; Michael Rugaard Jensen; Emanuela Frittoli; Kristian Helin
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry.
Nature genetics 2002;31(2):190-4.
2002: Emma S Hickman; Kristian Helin
The regulation of APAF1 expression during development and tumourigenesis.
Apoptosis : an international journal on programmed cell death 2002;7(2):167-71.
2002: Emma S Hickman; M Cristina Moroni; Kristian Helin
The role of p53 and pRB in apoptosis and cancer.
Current opinion in genetics & development 2002;12(1):60-6.
2001: Luigi Sironi; Marina Melixetian; Mario Faretta; Elena Prosperini; Kristian Helin; Andrea Musacchio
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.
The EMBO journal 2001;20(22):6371-82.
2001: Andre Fortin; Sean P Cregan; Jason G MacLaurin; Neena Kushwaha; Emma S Hickman; C S Thompson; A Hakim; Paul R Albert; Francesco Cecconi; Kristian Helin; David Park; ruth slack
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.
The Journal of cell biology 2001;155(2):207-16.
2001: M Cristina Moroni; Emma S Hickman; eros lazzerini denchi; G Caprara; E Colli; Francesco Cecconi; Heiko Müller; Kristian Helin
Apaf-1 is a transcriptional target for E2F and p53.
Nature cell biology 2001;3(6):552-8.
2001: Heiko Müller; Adrian P Bracken; R Vernell; M Cristina Moroni; F Christians; E Grassilli; Elena Prosperini; E Vigo; J D Oliner; Kristian Helin
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.
Genes & development 2001;15(3):267-85.
2000: L Wu; Edward C Goodwin; LK Naeger; E Vigo; K Galaktionov; Kristian Helin; Daniel DiMaio
E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression.
Molecular and cellular biology 2000;20(19):7059-67.
2000: BO Petersen; C Wagener; Federica Marinoni; ER Kramer; Marina Melixetian; eros lazzerini denchi; Christian Gieffers; C Matteucci; Jan-Michael Peters; Kristian Helin
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.
Genes & development 2000;14(18):2330-43.
2000: Peter Cartwright; Kristian Helin
Nucleocytoplasmic shuttling of transcription factors.
Cellular and molecular life sciences : CMLS 2000;57(8-9):1193-206.
2000: G Marzio; Christian Wagener; Maria Ines Gutierrez; Peter Cartwright; Kristian Helin; Mauro Giacca
E2F family members are differentially regulated by reversible acetylation.
The Journal of biological chemistry 2000;275(15):10887-92.
2000: Heiko Müller; Kristian Helin
The E2F transcription factors: key regulators of cell proliferation.
Biochimica et biophysica acta 2000;1470(1):M1-12.
2000: Emma S Hickman; Kristian Helin
The p53 tumour suppressor protein.
Biotechnology & genetic engineering reviews 2000;17():179-211.
1999: E Vigo; Heiko Müller; Elena Prosperini; G Hateboer; Peter Cartwright; M Cristina Moroni; Kristian Helin
CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase.
Molecular and cellular biology 1999;19(9):6379-95.
1999: BO Petersen; J Lukas; C S Sørensen; Jiri Bartek; Kristian Helin
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
The EMBO journal 1999;18(2):396-410.
1998: G Hateboer; A Wobst; BO Petersen; Laurent Le Cam; E Vigo; Claude Sardet; Kristian Helin
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.
Molecular and cellular biology 1998;18(11):6679-97.
1998: Peter Cartwright; Heiko Müller; Christian Wagener; K Holm; Kristian Helin
E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.
Oncogene 1998;17(5):611-23.
1998: C Holmberg; Kristian Helin; Maxwell Sehested; O Karlström
E2F-1-induced p53-independent apoptosis in transgenic mice.
Oncogene 1998;17(2):143-55.
1998: Kristian Helin
Regulation of cell proliferation by the E2F transcription factors.
Current opinion in genetics & development 1998;8(1):28-35.
1998: Myriam Alcalay; L Tomassoni; Emanuela Colombo; S Stoldt; Francesco Grignani; Marta Fagioli; L Szekely; Kristian Helin; Pier Giuseppe Pelicci
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein.
Molecular and cellular biology 1998;18(2):1084-93.
1998: Kristian Helin; G Peters
Tumor suppressors: from genes to function and possible therapies.
Trends in genetics : TIG 1998;14(1):8-9.
1997: Heiko Müller; M Cristina Moroni; E Vigo; BO Petersen; Jiri Bartek; Kristian Helin
Induction of S-phase entry by E2F transcription factors depends on their nuclear localization.
Molecular and cellular biology 1997;17(9):5508-20.
1997: Kristian Helin; K Holm; A Niebuhr; H Eiberg; Niels Tommerup; S Hougaard; Hans Skovgaard Poulsen; Mogens Spang-Thomsen; P Norgaard
Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6933-8.
1996: Jiri Lukas; BO Petersen; K Holm; Jiri Bartek; Kristian Helin
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression.
Molecular and cellular biology 1996;16(3):1047-57.