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Donald Helinski

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
12
Toukdarian, Aresa
11
Konieczny, Igor
7
Filutowicz, Marcin
6
Zhong, Zhenping
6
McEachern, Michael J.
5
Caspi, Ron
4
Doran, Kelly
4
Lois, Augusto
4
mincer, tracy
4
Yao, Shiyin
3
Wilkinson, Jane
3
DeLoughery, Craig
3
Knauf, Vic
3
Pacek, Marcin
3
Sobecky, PA

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Publications

TOP 3
Verheust Celine; Helinski Donald R
The incC korB region of RK2 repositions a mini-RK2 replicon in Escherichia coli.
Yao Shiyin; Helinski Donald R; Toukdarian Aresa
Localization of the naturally occurring plasmid ColE1 at the cell pole.
Yao Shiyin; Toukdarian Aresa; Helinski Donald R
Inhibition of protein and RNA synthesis in Escherichia coli results in declustering of plasmid RK2.

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All Publications

2007: Verheust Celine; Helinski Donald R
The incC korB region of RK2 repositions a mini-RK2 replicon in Escherichia coli.
Plasmid 2007;58(2):195-204.
2007: Yao Shiyin; Helinski Donald R; Toukdarian Aresa
Localization of the naturally occurring plasmid ColE1 at the cell pole.
Journal of bacteriology 2007;189(5):1946-53.
2006: Yao Shiyin; Toukdarian Aresa; Helinski Donald R
Inhibition of protein and RNA synthesis in Escherichia coli results in declustering of plasmid RK2.
Plasmid 2006;56(2):124-32.
2006: Jiang Yong; Yao Shiyin; Helinski Donald; Toukdarian Aresa
Functional analysis of two putative chromosomal replication origins from Pseudomonas aeruginosa.
Plasmid 2006;55(3):194-200.
2005: Zhong Zhenping; Helinski Donald; Toukdarian Aresa
Plasmid host-range: restrictions to F replication in Pseudomonas.
Plasmid 2005;54(1):48-56.
2005: Johnson Erik P; Yao Shiyin; Helinski Donald R
Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli.
Journal of bacteriology 2005;187(10):3538-47.
2003: Zhong Zhenping; Helinski Donald; Toukdarian Aresa
A specific region in the N terminus of a replication initiation protein of plasmid RK2 is required for recruitment of Pseudomonas aeruginosa DnaB helicase to the plasmid origin.
The Journal of biological chemistry 2003;278(46):45305-10.
2003: Jiang Yong; Pacek Marcin; Helinski Donald R; Konieczny Igor; Toukdarian Aresa
A multifunctional plasmid-encoded replication initiation protein both recruits and positions an active helicase at the replication origin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8692-7.
2003: Zhong Zhenping; Caspi Ron; Helinski Donald; Knauf Vic; Sykes Sean; O'Byrne Colleen; Shea Terrance P; Wilkinson Jane E; DeLoughery Craig; Toukdarian Aresa
Nucleotide sequence based characterizations of two cryptic plasmids from the marine bacterium Ruegeria isolate PR1b.
Plasmid 2003;49(3):233-52.
2002: Jiang Yong; Pogliano Joe; Helinski Donald R; Konieczny Igor
ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase.
Molecular microbiology 2002;44(4):971-9.
2002: Zhong Zhenping; Caspi Ron; Mincer Tracy; Helinski Donald; Knauf Vic; Boardman Kari; Wilkinson Jane E; Shea Terry; DeLoughery Craig; Toukdarian Aresa
A 50-kb plasmid rich in mobile gene sequences isolated from a marine micrococcus.
Plasmid 2002;47(1):1-9.
2001: Zhong Z; Toukdarian A; Helinski D; Knauf V; Sykes S; Wilkinson J E; O'Bryne C; Shea T; DeLoughery C; Caspi R
Sequence analysis of a 101-kilobase plasmid required for agar degradation by a Microscilla isolate.
Applied and environmental microbiology 2001;67(12):5771-9.
2001: Caspi R; Pacek M; Consiglieri G; Helinski D R; Toukdarian A; Konieczny I
A broad host range replicon with different requirements for replication initiation in three bacterial species.
The EMBO journal 2001;20(12):3262-71.
2001: Pogliano J; Ho T Q; Zhong Z; Helinski D R
Multicopy plasmids are clustered and localized in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4486-91.
2000: Caspi R; Helinski D R; Pacek M; Konieczny I
Interactions of DnaA proteins from distantly related bacteria with the replication origin of the broad host range plasmid RK2.
The Journal of biological chemistry 2000;275(24):18454-61.
1999: Johnson E P; Mincer T; Schwab H; Burgin A B; Helinski D R
Plasmid RK2 ParB protein: purification and nuclease properties.
Journal of bacteriology 1999;181(19):6010-8.
1999: Doran K S; Helinski D R; Konieczny I
Host-dependent requirement for specific DnaA boxes for plasmid RK2 replication.
Molecular microbiology 1999;33(3):490-8.
1999: Doran K S; Helinski D R; Konieczny I
A critical DnaA box directs the cooperative binding of the Escherichia coli DnaA protein to the plasmid RK2 replication origin.
The Journal of biological chemistry 1999;274(25):17918-23.
1998: Toukdarian A E; Helinski D R
TrfA dimers play a role in copy-number control of RK2 replication.
Gene 1998;223(1-2):205-11.
1998: Easter C L; Schwab H; Helinski D R
Role of the parCBA operon of the broad-host-range plasmid RK2 in stable plasmid maintenance.
Journal of bacteriology 1998;180(22):6023-30.
1998: Sobecky P A; Mincer T J; Chang M C; Toukdarian A; Helinski D R
Isolation of broad-host-range replicons from marine sediment bacteria.
Applied and environmental microbiology 1998;64(8):2822-30.
1998: Doran K S; Konieczny I; Helinski D R
Replication origin of the broad host range plasmid RK2. Positioning of various motifs is critical for initiation of replication.
The Journal of biological chemistry 1998;273(14):8447-53.
1997: Konieczny I; Helinski D R
Helicase delivery and activation by DnaA and TrfA proteins during the initiation of replication of the broad host range plasmid RK2.
The Journal of biological chemistry 1997;272(52):33312-8.
1997: Konieczny I; Helinski D R
The replication initiation protein of the broad-host-range plasmid RK2 is activated by the ClpX chaperone.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14378-82.
1997: Easter C L; Sobecky P A; Helinski D R
Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2.
Journal of bacteriology 1997;179(20):6472-9.
1997: Konieczny I; Doran K S; Helinski D R; Blasina A
Role of TrfA and DnaA proteins in origin opening during initiation of DNA replication of the broad host range plasmid RK2.
The Journal of biological chemistry 1997;272(32):20173-8.
1997: Sobecky P A; Mincer T J; Chang M C; Helinski D R
Plasmids isolated from marine sediment microbial communities contain replication and incompatibility regions unrelated to those of known plasmid groups.
Applied and environmental microbiology 1997;63(3):888-95.
1996: Blasina A; Kittell B L; Toukdarian A E; Helinski D R
Copy-up mutants of the plasmid RK2 replication initiation protein are defective in coupling RK2 replication origins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3559-64.
1996: Sobecky P A; Easter C L; Bear P D; Helinski D R
Characterization of the stable maintenance properties of the par region of broad-host-range plasmid RK2.
Journal of bacteriology 1996;178(7):2086-93.
1996: Toukdarian A E; Helinski D R; Perri S
The plasmid RK2 initiation protein binds to the origin of replication as a monomer.
The Journal of biological chemistry 1996;271(12):7072-8.
1996: Johnson E P; Strom A R; Helinski D R
Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein.
Journal of bacteriology 1996;178(5):1420-9.
1995: Sia E A; Roberts R C; Easter C; Helinski D R; Figurski D H
Different relative importances of the par operons and the effect of conjugal transfer on the maintenance of intact promiscuous plasmid RK2.
Journal of bacteriology 1995;177(10):2789-97.
1995: Wegrzyn G; Wegrzyn A; Konieczny I; Bielawski K; Konopa G; Obuchowski M; Helinski D R; Taylor K
Involvement of the host initiator function dnaA in the replication of coliphage lambda.
Genetics 1995;139(4):1469-81.
1995: Monson E K; Ditta G S; Helinski D R
The oxygen sensor protein, FixL, of Rhizobium meliloti. Role of histidine residues in heme binding, phosphorylation, and signal transduction.
The Journal of biological chemistry 1995;270(10):5243-50.
1994: Agron P G; Monson E K; Ditta G S; Helinski D R
Oxygen regulation of expression of nitrogen fixation genes in Rhizobium meliloti.
Research in microbiology 1994;145(5-6):454-9.
1994: Roberts R C; Ström A R; Helinski D R
The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss.
Journal of molecular biology 1994;237(1):35-51.
1994: Cereghino J L; Helinski D R; Toukdarian A E
Isolation and characterization of DNA-binding mutants of a plasmid replication initiation protein utilizing an in vivo binding assay.
Plasmid 1994;31(1):89-99.
1993: Roberts R C; Spangler C; Helinski D R
Characteristics and significance of DNA binding activity of plasmid stabilization protein ParD from the broad host-range plasmid RK2.
The Journal of biological chemistry 1993;268(36):27109-17.
1993: Weinstein M; Lois A F; Ditta G S; Helinski D R
Mutants of the two-component regulatory protein FixJ of Rhizobium meliloti that have increased activity at the nifA promoter.
Gene 1993;134(2):145-52.
1993: Cereghino J L; Helinski D R
Essentiality of the three carboxyl-terminal amino acids of the plasmid RK2 replication initiation protein TrfA for DNA binding and replication activity in gram-negative bacteria.
The Journal of biological chemistry 1993;268(33):24926-32.
1993: Fang F C; Durland R H; Helinski D R
Mutations in the gene encoding the replication-initiation protein of plasmid RK2 produce elevated copy numbers of RK2 derivatives in Escherichia coli and distantly related bacteria.
Gene 1993;133(1):1-8.
1993: Agron P G; Ditta G S; Helinski D R
Oxygen regulation of nifA transcription in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3506-10.
1993: Lois A F; Ditta G S; Helinski D R
The oxygen sensor FixL of Rhizobium meliloti is a membrane protein containing four possible transmembrane segments.
Journal of bacteriology 1993;175(4):1103-9.
1993: Perri S; Helinski D R
DNA sequence requirements for interaction of the RK2 replication initiation protein with plasmid origin repeats.
The Journal of biological chemistry 1993;268(5):3662-9.
1993: Lois A F; Weinstein M; Ditta G S; Helinski D R
Autophosphorylation and phosphatase activities of the oxygen-sensing protein FixL of Rhizobium meliloti are coordinately regulated by oxygen.
The Journal of biological chemistry 1993;268(6):4370-5.
1992: Roberts R C; Helinski D R
Definition of a minimal plasmid stabilization system from the broad-host-range plasmid RK2.
Journal of bacteriology 1992;174(24):8119-32.
1992: Weinstein M; Roberts R C; Helinski D R
A region of the broad-host-range plasmid RK2 causes stable in planta inheritance of plasmids in Rhizobium meliloti cells isolated from alfalfa root nodules.
Journal of bacteriology 1992;174(22):7486-9.
1992: Weinstein M; Lois A F; Monson E K; Ditta G S; Helinski D R
Isolation of phosphorylation-deficient mutants of the Rhizobium meliloti two-component regulatory protein, FixJ.
Molecular microbiology 1992;6(15):2041-9.
1992: Davis T L; Helinski D R; Roberts R C
Transcription and autoregulation of the stabilizing functions of broad-host-range plasmid RK2 in Escherichia coli, Agrobacterium tumefaciens and Pseudomonas aeruginosa.
Molecular microbiology 1992;6(14):1981-94.
1992: Agron P G; Ditta G S; Helinski D R
Mutational analysis of the Rhizobium meliloti nifA promoter.
Journal of bacteriology 1992;174(12):4120-9.
1992: Lin J; Helinski D R
Analysis of mutations in trfA, the replication initiation gene of the broad-host-range plasmid RK2.
Journal of bacteriology 1992;174(12):4110-9.
1992: Monson E K; Weinstein M; Ditta G S; Helinski D R
The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4280-4.
1992: Greener A; Lehman S M; Helinski D R
Promoters of the broad host range plasmid RK2: analysis of transcription (initiation) in five species of gram-negative bacteria.
Genetics 1992;130(1):27-36.
1991: Fang F C; Helinski D R
Broad-host-range properties of plasmid RK2: importance of overlapping genes encoding the plasmid replication initiation protein TrfA.
Journal of bacteriology 1991;173(18):5861-8.
1991: Perri S; Helinski D R; Toukdarian A
Interactions of plasmid-encoded replication initiation proteins with the origin of DNA replication in the broad host range plasmid RK2.
The Journal of biological chemistry 1991;266(19):12536-43.
1991: Valla S; Haugan K; Durland R; Helinski D R
Isolation and properties of temperature-sensitive mutants of the trfA gene of the broad host range plasmid RK2.
Plasmid 1991;25(2):131-6.
1991: Gilles-Gonzalez M A; Ditta G S; Helinski D R
A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti.
Nature 1991;350(6314):170-2.
1991: Kittell B L; Helinski D R
Iteron inhibition of plasmid RK2 replication in vitro: evidence for intermolecular coupling of replication origins as a mechanism for RK2 replication control.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1389-93.
1990: Roberts R C; Burioni R; Helinski D R
Genetic characterization of the stabilizing functions of a region of broad-host-range plasmid RK2.
Journal of bacteriology 1990;172(11):6204-16.
1990: Greener A; Filutowicz M S; McEachern M J; Helinski D R
N-terminal truncated forms of the bifunctional pi initiation protein express negative activity on plasmid R6K replication.
Molecular & general genetics : MGG 1990;224(1):24-32.
1990: Durland R H; Toukdarian A; Fang F; Helinski D R
Mutations in the trfA replication gene of the broad-host-range plasmid RK2 result in elevated plasmid copy numbers.
Journal of bacteriology 1990;172(7):3859-67.
1990: Durland R H; Helinski D R
Replication of the broad-host-range plasmid RK2: direct measurement of intracellular concentrations of the essential TrfA replication proteins and their effect on plasmid copy number.
Journal of bacteriology 1990;172(7):3849-58.
1990: Dylan T; Nagpal P; Helinski D R; Ditta G S
Symbiotic pseudorevertants of Rhizobium meliloti ndv mutants.
Journal of bacteriology 1990;172(3):1409-17.
1990: Dylan T; Helinski D R; Ditta G S
Hypoosmotic adaptation in Rhizobium meliloti requires beta-(1----2)-glucan.
Journal of bacteriology 1990;172(3):1400-8.
1990: Ielpi L; Dylan T; Ditta G S; Helinski D R; Stanfield S W
The ndvB locus of Rhizobium meliloti encodes a 319-kDa protein involved in the production of beta-(1----2)-glucan.
The Journal of biological chemistry 1990;265(5):2843-51.
1989: McEachern M J; Bott M A; Tooker P A; Helinski D R
Negative control of plasmid R6K replication: possible role of intermolecular coupling of replication origins.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7942-6.
1989: Kittell B L; Helinski D R; Ditta G S
Aromatic aminotransferase activity and indoleacetic acid production in Rhizobium meliloti.
Journal of bacteriology 1989;171(10):5458-66.
1989: Palomares A J; DeLuca M A; Helinski D R
Firefly luciferase as a reporter enzyme for measuring gene expression in vegetative and symbiotic Rhizobium meliloti and other gram-negative bacteria.
Gene 1989;81(1):55-64.
1989: Schmidhauser T J; Bechhofer D H; Figurski D H; Helinski D R
Host-specific effects of the korA-korB operon and oriT region on the maintenance of miniplasmid derivatives of broad host-range plasmid RK2.
Plasmid 1989;21(2):99-112.
1988: Stanfield S W; Ielpi L; O'Brochta D; Helinski D R; Ditta G S
The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB.
Journal of bacteriology 1988;170(8):3523-30.
1988: Virts E L; Stanfield S W; Helinski D R; Ditta G S
Common regulatory elements control symbiotic and microaerobic induction of nifA in Rhizobium meliloti.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3062-5.
1988: Schmidhauser T J; Ditta G; Helinski D R
Broad-host-range plasmid cloning vectors for gram-negative bacteria.
Biotechnology (Reading, Mass.) 1988;10():287-332.
1987: Durland R H; Helinski D R
The sequence encoding the 43-kilodalton trfA protein is required for efficient replication or maintenance of minimal RK2 replicons in Pseudomonas aeruginosa.
Plasmid 1987;18(2):164-9.
1987: Filutowicz M; McEachern M J; Mukhopadhyay P; Greener A; Yang S L; Helinski D R
DNA and protein interactions in the regulation of plasmid replication.
Journal of cell science. Supplement 1987;7():15-31.
1986: Filutowicz M; McEachern M J; Helinski D R
Positive and negative roles of an initiator protein at an origin of replication.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9645-9.
1986: Mukhopadhyay P; Filutowicz M; Helinski D R
Replication from one of the three origins of the plasmid R6K requires coupled expression of two plasmid-encoded proteins.
The Journal of biological chemistry 1986;261(20):9534-9.
1986: Stanfield S W; Helinski D R
Multiple mechanisms generate extrachromosomal circular DNA in Chinese hamster ovary cells.
Nucleic acids research 1986;14(8):3527-38.
1985: Better M; Ditta G; Helinski D R
Deletion analysis of Rhizobium meliloti symbiotic promoters.
The EMBO journal 1985;4(10):2419-24.
1985: Schmidhauser T J; Helinski D R
Regions of broad-host-range plasmid RK2 involved in replication and stable maintenance in nine species of gram-negative bacteria.
Journal of bacteriology 1985;164(1):446-55.
1985: Chikami G K; Guiney D G; Schmidhauser T J; Helinski D R
Comparison of 10 IncP plasmids: homology in the regions involved in plasmid replication.
Journal of bacteriology 1985;162(2):656-60.
1985: McEachern M J; Filutowicz M; Helinski D R
Mutations in direct repeat sequences and in a conserved sequence adjacent to the repeats result in a defective replication origin in plasmid R6K.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(5):1480-4.
1985: Ditta G; Schmidhauser T; Yakobson E; Lu P; Liang X W; Finlay D R; Guiney D; Helinski D R
Plasmids related to the broad host range vector, pRK290, useful for gene cloning and for monitoring gene expression.
Plasmid 1985;13(2):149-53.
1985: Filutowicz M; Davis G; Greener A; Helinski D R
Autorepressor properties of the pi-initiation protein encoded by plasmid R6K.
Nucleic acids research 1985;13(1):103-14.
1985: Filutowicz M; McEachern M; Greener A; Mukhopadhyay P; Uhlenhopp E; Durland R; Helinski D
Role of the pi initiation protein and direct nucleotide sequence repeats in the regulation of plasmid R6K replication.
Basic life sciences 1985;30():125-40.
1984: Stanfield S W; Helinski D R
Cloning and characterization of small circular DNA from Chinese hamster ovary cells.
Molecular and cellular biology 1984;4(1):173-80.
1983: Better M; Lewis B; Corbin D; Ditta G; Helinski D R
Structural relationships among Rhizobium meliloti symbiotic promoters.
Cell 1983;35(2 Pt 1):479-85.
1983: Schmidhauser T J; Filutowicz M; Helinski D R
Replication of derivatives of the broad host range plasmid RK2 in two distantly related bacteria.
Plasmid 1983;9(3):325-30.
1982: Corbin D; Ditta G; Helinski D R
Clustering of nitrogen fixation (nif) genes in Rhizobium meliloti.
Journal of bacteriology 1982;149(1):221-8.
1980: Ditta G; Stanfield S; Corbin D; Helinski D R
Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(12):7347-51.

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