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Thomas Helleday

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Oliver Mortusewicz; Patrick Herr; Thomas Helleday
Early replication fragile sites: where replication-transcription collisions cause genetic instability.
Natalia Kotova; Niklas Schultz; Maciej Stepnik; Daniel Vare; Dobroslawa Gradecka Meesters; Jan Grawé; Thomas Helleday; Dag Jenssen
Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.
Nils H Nicolay; Remko Prevo; Niklas Schultz; Rebecca Carter; Stephanie B Hatch; Thomas Helleday; W Gillies McKenna; Ricky A Sharma
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.

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All Publications

2013: Oliver Mortusewicz; Patrick Herr; Thomas Helleday
Early replication fragile sites: where replication-transcription collisions cause genetic instability.
The EMBO journal 2013;32(4):493-5.
2013: Natalia Kotova; Niklas Schultz; Maciej Stepnik; Daniel Vare; Dobroslawa Gradecka Meesters; Jan Grawé; Thomas Helleday; Dag Jenssen
Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.
Carcinogenesis 2013;34(2):325-30.
2012: Nils H Nicolay; Remko Prevo; Niklas Schultz; Rebecca Carter; Stephanie B Hatch; Thomas Helleday; W Gillies McKenna; Ricky A Sharma
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
Carcinogenesis 2012;33(11):2026-34.
2012: Ingegerd Elvers; Klaus Erixon; Anna Hagenkort; Fredrik Johansson; Anne Lagerqvist; Niklas Schultz; Ivaylo Stoimenov; Tatjana Djureinovic; Thomas Helleday
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation.
Nucleic acids research 2012;40(17):8440-8.
2012: Petra Groth; Anne Lagerqvist; Muntasir Mamun Majumder; Manuel Luís Orta; Ingegerd Elvers; Thomas Helleday
Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation.
Nucleic acids research 2012;40(14):6585-94.
2012: Songmin Ying; Freddie C Hamdy; Thomas Helleday
Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.
Cancer research 2012;72(11):2814-21.
2012: Vicky Chatzakos; Tatjana Djureinovic; Thomas Helleday; Katharina Slätis; Mary C Hunt
N-acyl taurines are anti-proliferative in prostate cancer cells.
Lipids 2012;47(4):355-61.
2012: Firas L T Al-Ubaidi; Lars Egevad; Torvald Granfors; Niklas Schultz; Thomas Helleday
Castration therapy of prostate cancer results in downregulation of HIF-1α levels.
International journal of radiation oncology, biology, physics 2012;82(3):1243-8.
2012: Evgenia Gubanova; Thomas Helleday; Sergei V Ivanov; Gordon B Mills; Wendell G Yarbrough; Brandee Brown; Natalia Issaeva
Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1257-67.
2012: Nils H Nicolay; Thomas Helleday; Ricky A Sharma
Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.
Current molecular pharmacology 2012;5(1):54-67.
2011: Thomas Helleday
DNA repair as treatment target.
European journal of cancer (Oxford, England : 1990) 2011;47 Suppl 3():S333-5.
2011: Linda M Svensson; Matthieu Desroses; Thomas Helleday; Martin Högbom; Ann-Sofie Jemth; Olga Loseva; Pål Stenmark
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.
FEBS letters 2011;585(16):2617-21.
2011: Thomas Helleday
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings.
Molecular oncology 2011;5(4):387-93.
2011: Osama Al-Assar; Thomas Helleday; Guy Kingham; Serena Lunardi; Tine Mantoni; Thomas B Brunner
Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction.
Cancer biology & therapy 2011;11(12):1028-35.
2011: Ivaylo Stoimenov; Ponnari Gottipati; Niklas Schultz; Thomas Helleday
Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells.
Mutation research 2011;706(1-2):1-6.
2011: Ivaylo Stoimenov; Niklas Schultz; Ponnari Gottipati; Thomas Helleday
Transcription inhibition by DRB potentiates recombinational repair of UV lesions in mammalian cells.
PloS one 2011;6(5):e19492.
2011: Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Malgorzata Z Zdzienicka; Larry H Thompson; Thomas Helleday; Minoru Suzuki; Yuko Kinashi; Shinichiro Masunaga; Koji Ono; Masatoshi Hasegawa; Takeo Ohnishi
FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.
PloS one 2011;6(5):e19659.
2010: Eva Petermann; Mick Woodcock; Thomas Helleday
Chk1 promotes replication fork progression by controlling replication initiation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16090-5.
2010: Bastiaan Evers; Thomas Helleday; Jos Jonkers
Targeting homologous recombination repair defects in cancer.
Trends in pharmacological sciences 2010;31(8):372-80.
2010: Geoff S Higgins; Adrian L Harris; Remko Prevo; Thomas Helleday; W Gillies McKenna; Francesca M Buffa
Overexpression of POLQ confers a poor prognosis in early breast cancer patients.
Oncotarget 2010;1(3):175-84.
2010: Jason L Parsons; Irina I Dianova; David Finch; Phillip S Tait; Cecilia E Ström; Thomas Helleday; Grigory L Dianov
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.
DNA repair 2010;9(7):835-41.
2010: Thomas Helleday
Homologous recombination in cancer development, treatment and development of drug resistance.
Carcinogenesis 2010;31(6):955-60.
2010: Geoff S Higgins; Remko Prevo; Yin-Fai Lee; Thomas Helleday; Ruth J Muschel; Steve Taylor; Michio Yoshimura; Ian D Hickson; Eric J Bernhard; W Gillies McKenna
A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.
Cancer research 2010;70(7):2984-93.
2010: Olga Loseva; Ann-Sofie Jemth; Helen E Bryant; Herwig Schüler; Lari Lehtiö; Tobias Karlberg; Thomas Helleday
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
The Journal of biological chemistry 2010;285(11):8054-60.
2010: Halfdan Beck; Viola Nähse; Marie Sofie Yoo Larsen; Petra Groth; Trevor Clancy; Michael Lees; Mette Jørgensen; Thomas Helleday; Randi G Syljuåsen; Claus Storgaard Sørensen
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
The Journal of cell biology 2010;188(5):629-38.
2010: Eva Petermann; Manuel Luís Orta; Natalia Issaeva; Niklas Schultz; Thomas Helleday
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.
Molecular cell 2010;37(4):492-502.
2010: Thomas Helleday
Mutagenesis: mutating a gene while reading it.
Current biology : CB 2010;20(2):R57-8.
2009: Jennifer McLachlan; Serena Fernandez; Thomas Helleday; Helen E Bryant
Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.
DNA repair 2009;8(12):1424-33.
2009: Helen E Bryant; Eva Petermann; Niklas Schultz; Ann-Sofie Jemth; Olga Loseva; Natalia Issaeva; Fredrik Johansson; Serena Fernandez; Peter McGlynn; Thomas Helleday
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.
The EMBO journal 2009;28(17):2601-15.
2009: Ivaylo Stoimenov; Thomas Helleday
PCNA on the crossroad of cancer.
Biochemical Society transactions 2009;37(Pt 3):605-13.
2009: Lari Lehtiö; Ann-Sofie Jemth; Ruairi Collins; Olga Loseva; Andreas Johansson; Natalia Markova; Martin Hammarström; Alex Flores; Lovisa Holmberg Schiavone; Johan Weigelt; Thomas Helleday; Herwig Schüler; Tobias Karlberg
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
Journal of medicinal chemistry 2009;52(9):3108-11.
2009: Ponnari Gottipati; Thomas Helleday
Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination.
Mutagenesis 2009;24(3):203-10.
2008: Deborah Wilsker; Eva Petermann; Thomas Helleday; Fred Bunz
Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20752-7.
2008: Rene Rodriguez; Lasse Tengbjerg Hansen; Geraldine Phear; Jennifer Scorah; Mogens Spang-Thomsen; Angela Cox; Thomas Helleday; Mark Meuth
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5476-83.
2008: Wen-Hsing Cheng; Diana Muftic; Meltem Muftuoglu; Lale Dawut; Christa Morris; Thomas Helleday; Yosef Shiloh; Vilhelm A Bohr
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.
Molecular biology of the cell 2008;19(9):3923-33.
2008: Eva Petermann; Thomas Helleday; Keith W Caldecott
Claspin promotes normal replication fork rates in human cells.
Molecular biology of the cell 2008;19(6):2373-8.
2008: Lari Lehtiö; Ruairi Collins; Susanne van Den Berg; Andreas Johansson; Lars-Göran Dahlgren; Martin Hammarström; Thomas Helleday; Lovisa Holmberg Schiavone; Tobias Karlberg; Johan Weigelt
Zinc binding catalytic domain of human tankyrase 1.
Journal of molecular biology 2008;379(1):136-45.
2008: Thomas Helleday
Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy.
European journal of cancer (Oxford, England : 1990) 2008;44(7):921-7.
2008: Thomas Helleday; Eva Petermann; Cecilia Lundin; Ben Hodgson; Ricky A Sharma
DNA repair pathways as targets for cancer therapy.
Nature reviews. Cancer 2008;8(3):193-204.
2008: Ponnari Gottipati; Tobias N Cassel; Linda Savolainen; Thomas Helleday
Transcription-associated recombination is dependent on replication in Mammalian cells.
Molecular and cellular biology 2008;28(1):154-64.
2008: Ali Z Al-Minawi; Nasrollah Saleh-Gohari; Thomas Helleday
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells.
Nucleic acids research 2008;36(1):1-9.
2007: Stine Jørgensen; Ingegerd Elvers; Morten Beck Trelle; Tobias Menzel; Morten Eskildsen; Ole N Jensen; Thomas Helleday; Kristian Helin; Claus Storgaard Sørensen
The histone methyltransferase SET8 is required for S-phase progression.
The Journal of cell biology 2007;179(7):1337-45.
2007: E Petermann; Thomas Helleday
DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy.
Biochemical Society transactions 2007;35(Pt 5):1352-4.
2007: Kate M Sleeth; Claus Storgaard Sørensen; Natalia Issaeva; Jaroslaw Dziegielewski; Jiri Bartek; Thomas Helleday
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells.
Journal of molecular biology 2007;373(1):38-47.
2007: Thomas Helleday; Justin Lo; Dik C van Gent; Bevin P Engelward
DNA double-strand break repair: from mechanistic understanding to cancer treatment.
DNA repair 2007;6(7):923-35.
2007: Alihossein Saberi; Helfrid Hochegger; Dávid Szüts; Li Lan; Akira Yasui; Julian E Sale; Yoshihito Taniguchi; Yasuhiro Murakawa; Weihua Zeng; Kyoko Yokomori; Thomas Helleday; Hirobumi Teraoka; Hiroshi Arakawa; Jean-Marie Buerstedde; Shunichi Takeda
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
Molecular and cellular biology 2007;27(7):2562-71.
2007: A Renglin Lindh; Niklas Schultz; Nasrollah Saleh-Gohari; Thomas Helleday
RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis.
Cytogenetic and genome research 2007;116(1-2):38-45.
2006: Fredrik Johansson; Anne Lagerqvist; Silvia Filippi; Fabrizio Palitti; Klaus Erixon; Thomas Helleday; Dag Jenssen
Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines.
DNA repair 2006;5(12):1449-58.
2006: Jirina Bartkova; Nousin Rezaei; Michalis Liontos; Panagiotis Karakaidos; Dimitris Kletsas; Natalia Issaeva; Leandros-Vassilios F Vassiliou; Evangelos Kolettas; Katerina Niforou; Vassilis C Zoumpourlis; Munenori Takaoka; Hiroshi Nakagawa; Frederic Tort; Kasper Fugger; Fredrik Johansson; Maxwell Sehested; Claus L Andersen; Lars Dyrskjot; Torben F Ørntoft; Jiri Lukas; Christos Kittas; Thomas Helleday; Thanos D Halazonetis; Jiri Bartek; Vassilis G Gorgoulis
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Nature 2006;444(7119):633-7.
2006: Helen E Bryant; Songmin Ying; Thomas Helleday
Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells.
Mutation research 2006;599(1-2):116-23.
2006: Anna Renglin Lindh; Saeed Rafii; Niklas Schultz; Angela Cox; Thomas Helleday
Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility.
Human molecular genetics 2006;15(7):1217-24.
2006: Helen E Bryant; Thomas Helleday
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.
Nucleic acids research 2006;34(6):1685-91.
2005: Thomas Helleday; Helen E Bryant; Niklas Schultz
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.
Cell cycle (Georgetown, Tex.) 2005;4(9):1176-8.
2005: Nasrollah Saleh-Gohari; Helen E Bryant; Niklas Schultz; Kayan M Parker; Tobias N Cassel; Thomas Helleday
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks.
Molecular and cellular biology 2005;25(16):7158-69.
2005: Randi G Syljuåsen; Claus Storgaard Sørensen; Lasse Tengbjerg Hansen; Kasper Fugger; Cecilia Lundin; Fredrik Johansson; Thomas Helleday; Maxwell Sehested; Jiri Lukas; Jiri Bartek
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.
Molecular and cellular biology 2005;25(9):3553-62.
2005: Helen E Bryant; Niklas Schultz; Huw D Thomas; Kayan M Parker; Dan Flower; Elena Lopez; Suzanne Kyle; Mark Meuth; Nicola J Curtin; Thomas Helleday
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Nature 2005;434(7035):913-7.
2005: Sherif F El-Khamisy; Gulam M Saifi; Michael Weinfeld; Fredrik Johansson; Thomas Helleday; James R Lupski; Keith W Caldecott
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.
Nature 2005;434(7029):108-13.
2005: Claus Storgaard Sørensen; Lasse Tengbjerg Hansen; Jaroslaw Dziegielewski; Randi G Syljuåsen; Cecilia Lundin; Jiri Bartek; Thomas Helleday
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.
Nature cell biology 2005;7(2):195-201.
2005: Cecilia Lundin; Matthew North; Klaus Erixon; Kevin Walters; Dag Jenssen; Alastair S H Goldman; Thomas Helleday
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.
Nucleic acids research 2005;33(12):3799-811.
2005: Clarisse Bavoux; Andreia Leopoldino; Valérie Bergoglio; Jiyang O-Wang; Tomoo Ogi; Anne Bieth; Jean-Gabriel Judde; Sergio Pena; Marie-France Poupon; Thomas Helleday; Masatoshi Tagawa; Carlosrenato Machado; Jean-Sébastien Hoffmann; Christophe Cazaux
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
Cancer research 2005;65(1):325-30.
2004: Nasrollah Saleh-Gohari; Thomas Helleday
Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells.
Oncogene 2004;23(56):9136-41.
2004: Helen E Bryant; Thomas Helleday
Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents.
Biochemical Society transactions 2004;32(Pt 6):959-61.
2004: Emma Bolderson; Jennifer Scorah; Thomas Helleday; Carl Smythe; Mark Meuth
ATM is required for the cellular response to thymidine induced replication fork stress.
Human molecular genetics 2004;13(23):2937-45.
2004: Fredrik Johansson; Annika Allkvist; Klaus Erixon; Anna Malmvärn; Robert Nilsson; Ake Bergman; Thomas Helleday; Dag Jenssen
Screening for genotoxicity using the DRAG assay: investigation of halogenated environmental contaminants.
Mutation research 2004;563(1):35-47.
2004: Anuradha Kumari; Niklas Schultz; Thomas Helleday
p53 protects from replication-associated DNA double-strand breaks in mammalian cells.
Oncogene 2004;23(13):2324-9.
2004: Atul Mohindra; Emma Bolderson; Jason Stone; Michael Wells; Thomas Helleday; Mark Meuth
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.
Human molecular genetics 2004;13(2):203-12.
2004: Nasrollah Saleh-Gohari; Thomas Helleday
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells.
Nucleic acids research 2004;32(12):3683-8.
2003: Thomas Helleday
Pathways for mitotic homologous recombination in mammalian cells.
Mutation research 2003;532(1-2):103-15.
2003: Niklas Schultz; Elena Lopez; Nasrollah Saleh-Gohari; Thomas Helleday
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.
Nucleic acids research 2003;31(17):4959-64.
2003: Lasse Tengbjerg Hansen; Cecilia Lundin; Mogens Spang-Thomsen; Lone Nørgård Petersen; Thomas Helleday
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
International journal of cancer. Journal international du cancer 2003;105(4):472-9.
2003: Cecilia Lundin; Niklas Schultz; Catherine Arnaudeau; Atul Mohindra; Lasse Tengbjerg Hansen; Thomas Helleday
RAD51 is involved in repair of damage associated with DNA replication in mammalian cells.
Journal of molecular biology 2003;328(3):521-35.
2003: Lasse Tengbjerg Hansen; Cecilia Lundin; Thomas Helleday; Hans Skovgaard Poulsen; Claus Storgaard Sørensen; Lone Nørgård Petersen; Mogens Spang-Thomsen
DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2003;40(2):157-64.
2003: John M Hinz; Thomas Helleday; Mark Meuth
Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.
Carcinogenesis 2003;24(2):249-53.
2002: Atul Mohindra; Laura E Hays; Eric N Phillips; Bradley D Preston; Thomas Helleday; Mark Meuth
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines.
Human molecular genetics 2002;11(18):2189-200.
2002: Cecilia Lundin; Magnus K R Samuelsson; Thomas Helleday
Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells.
Biochemical and biophysical research communications 2002;296(2):363-7.
2002: Cecilia Lundin; Klaus Erixon; Catherine Arnaudeau; Niklas Schultz; Dag Jenssen; Mark Meuth; Thomas Helleday
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells.
Molecular and cellular biology 2002;22(16):5869-78.
2001: G Olsson; Igor Y Belyaev; Thomas Helleday; Mats Harms-Ringdahl
ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination.
Mutation research 2001;493(1-2):55-66.
2001: Thomas Helleday; Fredrik Johansson; Dag Jenssen
The DRAG test: an assay for detection of genotoxic damage.
Alternatives to laboratory animals : ATLA 2001;29(3):233-41.
2001: Catherine Arnaudeau; Cecilia Lundin; Thomas Helleday
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells.
Journal of molecular biology 2001;307(5):1235-45.
2001: Catherine Arnaudeau; L Rozier; Christophe Cazaux; Martine Defais; Dag Jenssen; Thomas Helleday
RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors.
Nucleic acids research 2001;29(3):662-7.
2000: Catherine Arnaudeau; E Tenorio Miranda; Dag Jenssen; Thomas Helleday
Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells.
Mutation research 2000;461(3):221-8.
2000: Thomas Helleday; Robert Nilsson; Dag Jenssen
Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells.
Environmental and molecular mutagenesis 2000;35(2):114-22.
1999: Catherine Arnaudeau; Thomas Helleday; Dag Jenssen
The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells.
Journal of molecular biology 1999;289(5):1231-8.
1999: Thomas Helleday; K L Tuominen; Ake Bergman; Dag Jenssen
Brominated flame retardants induce intragenic recombination in mammalian cells.
Mutation research 1999;439(2):137-47.
1998: Thomas Helleday; Catherine Arnaudeau; Dag Jenssen
A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination.
Journal of molecular biology 1998;279(4):687-94.
1998: Thomas Helleday; Catherine Arnaudeau; Dag Jenssen
Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells.
Carcinogenesis 1998;19(6):973-8.