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Eva Helmerhorst

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Frank G Oppenheim; Eva J Helmerhorst; U Lendenmann; Gwynneth D Offner
Anti-candidal activity of genetically engineered histatin variants with multiple functional domains.
K Thomadaki; N Tian; D R Walt; Eva J Helmerhorst; Walter Luiz Siqueira; X Sun; Frank G Oppenheim
Whole-saliva proteolysis and its impact on salivary diagnostics.
Tomoko Komatsu; Erdjan Salih; Eva J Helmerhorst; Gwynneth D Offner; Frank G Oppenheim
Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry.

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All Publications

2012: Frank G Oppenheim; Eva J Helmerhorst; U Lendenmann; Gwynneth D Offner
Anti-candidal activity of genetically engineered histatin variants with multiple functional domains.
PloS one 2012;7(12):e51479.
2011: K Thomadaki; N Tian; D R Walt; Eva J Helmerhorst; Walter Luiz Siqueira; X Sun; Frank G Oppenheim
Whole-saliva proteolysis and its impact on salivary diagnostics.
Journal of dental research 2011;90(11):1325-30.
2011: Tomoko Komatsu; Erdjan Salih; Eva J Helmerhorst; Gwynneth D Offner; Frank G Oppenheim
Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry.
Journal of proteome research 2011;10(2):646-55.
2011: Homan Hanasab; Daniel Jammal; Frank G Oppenheim; Eva J Helmerhorst
The antifungal activity of human parotid secretion is species-specific.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2011;49(2):218-21.
2011: Maram Zamakhchari; Floyd Dewhirst; Jaeseop Lee; Frank G Oppenheim; Detlef Schuppan; Guoxian Wei; Eva J Helmerhorst
Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract.
PloS one 2011;6(9):e24455.
2010: Erdjan Salih; Walter Luiz Siqueira; Eva J Helmerhorst; Frank G Oppenheim
Large-scale phosphoproteome of human whole saliva using disulfide-thiol interchange covalent chromatography and mass spectrometry.
Analytical biochemistry 2010;407(1):19-33.
2010: Eva J Helmerhorst; Georges Traboulsi; Erdjan Salih; Frank G Oppenheim
Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains.
Journal of proteome research 2010;9(10):5413-21.
2010: Eva J Helmerhorst; Maram Zamakhchari; Detlef Schuppan; Frank G Oppenheim
Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity.
PloS one 2010;5(10):e13264.
2009: Xiuli Sun; Erdjan Salih; Frank G Oppenheim; Eva J Helmerhorst
Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2691-701.
2009: Melanie Campese; Xiuli Sun; Jos Bosch; Frank G Oppenheim; Eva J Helmerhorst
Concentration and fate of histatins and acidic proline-rich proteins in the oral environment.
Archives of oral biology 2009;54(4):345-53.
2009: Timothy M Blicharz; Walter L Siqueira; Eva J Helmerhorst; Frank G Oppenheim; Philip J Wexler; Frédéric F Little; David R Walt
Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva.
Analytical chemistry 2009;81(6):2106-14.
2009: Mitchell R White; Eva J Helmerhorst; Antoon J M Ligtenberg; M Karpel; Tesfaldet Tecle; Walter Luiz Siqueira; Frank G Oppenheim; Kevan L Hartshorn
Multiple components contribute to ability of saliva to inhibit influenza viruses.
Oral microbiology and immunology 2009;24(1):18-24.
2008: Timothy M Blicharz; David M Rissin; Michaela Bowden; Ryan B Hayman; Christopher DiCesare; Jasvinder S Bhatia; Nerline Grand-Pierre; Walter L Siqueira; Eva J Helmerhorst; Joseph Loscalzo; Frank G Oppenheim; David R Walt
Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle.
Clinical chemistry 2008;54(9):1473-80.
2008: Eva J Helmerhorst; Xiuli Sun; Erdjan Salih; Frank G Oppenheim
Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.
The Journal of biological chemistry 2008;283(29):19957-66.
2008: Walter Luiz Siqueira; Erdjan Salih; D L Wan; Eva J Helmerhorst; Frank G Oppenheim
Proteome of human minor salivary gland secretion.
Journal of dental research 2008;87(5):445-50.
2007: Eva J Helmerhorst; Frank G Oppenheim
Saliva: a dynamic proteome.
Journal of dental research 2007;86(8):680-93.
2007: Walter Luiz Siqueira; Weimin Zhang; Eva J Helmerhorst; Steven P Gygi; Frank G Oppenheim
Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS.
Journal of proteome research 2007;6(6):2152-60.
2007: Walter Luiz Siqueira; Eva J Helmerhorst; Weimin Zhang; Erdjan Salih; Frank G Oppenheim
Acquired enamel pellicle and its potential role in oral diagnostics.
Annals of the New York Academy of Sciences 2007;1098():504-9.
2007: Eva J Helmerhorst
Whole saliva proteolysis: wealth of information for diagnostic exploitation.
Annals of the New York Academy of Sciences 2007;1098():454-60.
2007: David R Walt; Timothy M Blicharz; Ryan B Hayman; David M Rissin; Michaela Bowden; Walter Luiz Siqueira; Eva J Helmerhorst; Nerline Grand-Pierre; Frank G Oppenheim; Jasvinder S Bhatia; Frédéric F Little; Jerome S Brody
Microsensor arrays for saliva diagnostics.
Annals of the New York Academy of Sciences 2007;1098():389-400.
2007: Frank G Oppenheim; Erdjan Salih; Walter Luiz Siqueira; Weimin Zhang; Eva J Helmerhorst
Salivary proteome and its genetic polymorphisms.
Annals of the New York Academy of Sciences 2007;1098():22-50.
2006: Eva J Helmerhorst; A S Alagl; Walter Luiz Siqueira; Frank G Oppenheim
Oral fluid proteolytic effects on histatin 5 structure and function.
Archives of oral biology 2006;51(12):1061-70.
2006: Marco Piludu; Maria Serenella Lantini; Margherita Cossu; Monica Piras; Frank G Oppenheim; Eva J Helmerhorst; Walter Luiz Siqueira; Arthur R Hand
Salivary histatins in human deep posterior lingual glands (of von Ebner).
Archives of oral biology 2006;51(11):967-73.
2006: Eva J Helmerhorst; Caterina Venuleo; Dominique Sanglard; Frank G Oppenheim
Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5.
Antimicrobial agents and chemotherapy 2006;50(3):1100-3.
2005: Eva J Helmerhorst; Caterina Venuleo; Anuradha Beri; Frank G Oppenheim
Candida glabrata is unusual with respect to its resistance to cationic antifungal proteins.
Yeast (Chichester, England) 2005;22(9):705-14.
2005: Eva J Helmerhorst; Maria Stan; Michael P Murphy; Fred Sherman; Frank G Oppenheim
The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicans.
Mitochondrion 2005;5(3):200-11.
2005: Richard D Mendelsohn; Eva J Helmerhorst; John F Cipollo; Maria A Kukuruzinska
A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast.
Biochimica et biophysica acta 2005;1723(1-3):33-44.
2004: Eva J Helmerhorst; Bianca Flora; Robert F Troxler; Frank G Oppenheim
Dialysis unmasks the fungicidal properties of glandular salivary secretions.
Infection and immunity 2004;72(5):2703-9.
2004: J Li; Eva J Helmerhorst; Yuan Yao; Martha E Nunn; Robert F Troxler; Frank G Oppenheim
Statherin is an in vivo pellicle constituent: identification and immuno-quantification.
Archives of oral biology 2004;49(5):379-85.
2004: Mansur Ahmad; Marco Piludu; Frank G Oppenheim; Eva J Helmerhorst; Arthur R Hand
Immunocytochemical localization of histatins in human salivary glands.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(3):361-70.
2004: J Li; Eva J Helmerhorst; C W Leone; Robert F Troxler; T Yaskell; A D Haffajee; Sigmund S Socransky; Frank G Oppenheim
Identification of early microbial colonizers in human dental biofilm.
Journal of applied microbiology 2004;97(6):1311-8.
2004: Heloisa Gusman; Cataldo W Leone; Eva J Helmerhorst; Martha E Nunn; Bianca Flora; Robert F Troxler; Frank G Oppenheim
Human salivary gland-specific daily variations in histatin concentrations determined by a novel quantitation technique.
Archives of oral biology 2004;49(1):11-22.
2004: J Li; Eva J Helmerhorst; Robert F Troxler; Frank G Oppenheim
Identification of in vivo pellicle constituents by analysis of serum immune responses.
Journal of dental research 2004;83(1):60-4.
2003: J Li; Eva J Helmerhorst; Ronald B Corley; Lia Luus; Robert F Troxler; Frank G Oppenheim
Characterization of the immunologic responses to human in vivo acquired enamel pellicle as a novel means to investigate its composition.
Oral microbiology and immunology 2003;18(3):183-91.
2002: Eva J Helmerhorst; Michael P Murphy; Robert F Troxler; Frank G Oppenheim
Characterization of the mitochondrial respiratory pathways in Candida albicans.
Biochimica et biophysica acta 2002;1556(1):73-80.
2002: Y Murakami; T Xu; Eva J Helmerhorst; G Ori; Robert F Troxler; E T Lally; Frank G Oppenheim
Inhibitory effect of synthetic histatin 5 on leukotoxin from Actinobacillus actinomycetemcomitans.
Oral microbiology and immunology 2002;17(3):143-9.
2002: David M Rothstein; Eva J Helmerhorst; Peter Spacciapoli; Frank G Oppenheim; Phillip Friden
Histatin-derived peptides: potential agents to treat localised infections.
Expert opinion on emerging drugs 2002;7(1):47-59.
2001: Eva J Helmerhorst; Robert F Troxler; Frank G Oppenheim
The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14637-42.
2001: Bianca Flora; Heloisa Gusman; Eva J Helmerhorst; Robert F Troxler; Frank G Oppenheim
A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation.
Protein expression and purification 2001;23(1):198-206.
2001: C Gyurko; U Lendenmann; Eva J Helmerhorst; Robert F Troxler; Frank G Oppenheim
Killing of Candida albicans by histatin 5: cellular uptake and energy requirement.
Antonie van Leeuwenhoek 2001;79(3-4):297-309.
2001: Anita L A Ruissen; Jasper Groenink; Eva J Helmerhorst; Els Walgreen-Weterings; Wim van't Hof; Enno C I Veerman; Arie V Nieuw Amerongen
Effects of histatin 5 and derived peptides on Candida albicans.
The Biochemical journal 2001;356(Pt 2):361-8.
2001: Wim Van 't Hof; Enno C I Veerman; Eva J Helmerhorst; Arie V Nieuw Amerongen
Antimicrobial peptides: properties and applicability.
Biological chemistry 2001;382(4):597-619.
2001: Heloisa Gusman; James Travis; Eva J Helmerhorst; Jan Potempa; Robert F Troxler; Frank G Oppenheim
Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.
Infection and immunity 2001;69(3):1402-8.
2001: Eva J Helmerhorst; Wim van't Hof; Pieter Breeuwer; Enno C I Veerman; T Abee; Robert F Troxler; Arie V Nieuw Amerongen; Frank G Oppenheim
Characterization of histatin 5 with respect to amphipathicity, hydrophobicity, and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation.
The Journal of biological chemistry 2001;276(8):5643-9.
2000: Wim van't Hof; IM Reijnders; Eva J Helmerhorst; Els Walgreen-Weterings; Ina M Simoons-Smit; Enno C I Veerman; Arie V Nieuw Amerongen
Synergistic effects of low doses of histatin 5 and its analogues on amphotericin B anti-mycotic activity.
Antonie van Leeuwenhoek 2000;78(2):163-9.
1999: Eva J Helmerhorst; R Hodgson; Wim Van 't Hof; Enno C I Veerman; C Allison; Arie V Nieuw Amerongen
The effects of histatin-derived basic antimicrobial peptides on oral biofilms.
Journal of dental research 1999;78(6):1245-50.
1999: Eva J Helmerhorst; IM Reijnders; Wim Van 't Hof; Enno C I Veerman; Arie V Nieuw Amerongen
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides.
FEBS letters 1999;449(2-3):105-10.
1999: Eva J Helmerhorst; Pieter Breeuwer; Wim van't Hof; Els Walgreen-Weterings; L C Oomen; Enno C I Veerman; Arie V Nieuw Amerongen; T Abee
The cellular target of histatin 5 on Candida albicans is the energized mitochondrion.
The Journal of biological chemistry 1999;274(11):7286-91.
1999: Eva J Helmerhorst; IM Reijnders; Wim van't Hof; Ina M Simoons-Smit; Enno C I Veerman; Arie V Nieuw Amerongen
Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides.
Antimicrobial agents and chemotherapy 1999;43(3):702-4.
1998: Eva J Helmerhorst; JJ Maaskant; Ben J Appelmelk
Anti-lipid A monoclonal antibody centoxin (HA-1A) binds to a wide variety of hydrophobic ligands.
Infection and immunity 1998;66(2):870-3.
1997: Eva J Helmerhorst; Wim van't Hof; Enno C I Veerman; Ina M Simoons-Smit; Arie V Nieuw Amerongen
Synthetic histatin analogues with broad-spectrum antimicrobial activity.
The Biochemical journal 1997;326 ( Pt 1)():39-45.
1995: Ben J Appelmelk; A Y Qing; Eva J Helmerhorst; JJ Maaskant; Philip Abraham; Lambertus G Thijs; D M MacLaren
Diversity in lipid A binding ligands: comparison of lipid A monoclonal antibodies with rBPI23.
Progress in clinical and biological research 1995;392():453-63.