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Heikki Helminen

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L Rieppo; Simo Saarakkala; Heikki J Helminen; Jukka S Jurvelin; T Närhi; Jarno Rieppo
Application of second derivative spectroscopy for increasing molecular specificity of Fourier transform infrared spectroscopic imaging of articular cartilage.
Mikael J Turunen; Heikki J Helminen; Jukka S Jurvelin; Simo Saarakkala; Hanna Isaksson
Age-related changes in organization and content of the collagen matrix in rabbit cortical bone.
Tommi Närhi; Ulrika Siitonen; Jukka S Jurvelin; Lauri J Lehto; Jari P A Arokoski; Pieter A Brama; Heikki J Helminen; Mika M Hyttinen; Petro Julkunen
Minor influence of lifelong voluntary exercise on composition, structure, and incidence of osteoarthritis in tibial articular cartilage of mice compared with major effects caused by growth, maturation, and aging.

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2012: L Rieppo; Simo Saarakkala; Heikki J Helminen; Jukka S Jurvelin; T Närhi; Jarno Rieppo
Application of second derivative spectroscopy for increasing molecular specificity of Fourier transform infrared spectroscopic imaging of articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012;20(5):451-9.
2012: Mikael J Turunen; Heikki J Helminen; Jukka S Jurvelin; Simo Saarakkala; Hanna Isaksson
Age-related changes in organization and content of the collagen matrix in rabbit cortical bone.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012;30(3):435-42.
2011: Tommi Närhi; Ulrika Siitonen; Jukka S Jurvelin; Lauri J Lehto; Jari P A Arokoski; Pieter A Brama; Heikki J Helminen; Mika M Hyttinen; Petro Julkunen
Minor influence of lifelong voluntary exercise on composition, structure, and incidence of osteoarthritis in tibial articular cartilage of mice compared with major effects caused by growth, maturation, and aging.
Connective tissue research 2011;52(5):380-92.
2011: Jarkko J P Jaatinen; Hannu Korhonen; Rami K Korhonen; Reijo Lappalainen; Alpo Pelttari; Heikki J Helminen; Heikki Kröger
Early bone growth on the surface of titanium implants in rat femur is enhanced by an amorphous diamond coating.
Acta orthopaedica 2011;82(4):499-503.
2011: Mikael J Turunen; Simo Saarakkala; Lassi Rieppo; Heikki J Helminen; Jukka S Jurvelin; Hanna Isaksson
Comparison between infrared and Raman spectroscopic analysis of maturing rabbit cortical bone.
Applied spectroscopy 2011;65(6):595-603.
2010: Hanna Isaksson; Marta Malkiewicz; Roman Nowak; Heikki J Helminen; Jukka S Jurvelin
Rabbit cortical bone tissue increases its elastic stiffness but becomes less viscoelastic with age.
Bone 2010;47(6):1030-8.
2010: Hanna Isaksson; Terhi Harjula; Arto Koistinen; Jarkko Iivarinen; Kari Seppänen; Jari P A Arokoski; Pieter A Brama; Jukka S Jurvelin; Heikki J Helminen
Collagen and mineral deposition in rabbit cortical bone during maturation and growth: effects on tissue properties.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(12):1626-33.
2010: Yevgeniya Kobrina; Hanna Isaksson; Miikka Sinisaari; Lassi Rieppo; Pieter A Brama; Rene van Weeren; Heikki J Helminen; Jukka S Jurvelin; Simo Saarakkala
Infrared spectroscopy reveals both qualitative and quantitative differences in equine subchondral bone during maturation.
Journal of biomedical optics 2010;15(6):067003.
2010: Petro Julkunen; Esa P Halmesmäki; Jarkko Iivarinen; Lassi Rieppo; Tommi Närhi; Juho Marjanen; Jarno Rieppo; Jari P A Arokoski; Pieter A Brama; Jukka S Jurvelin; Heikki J Helminen
Effects of growth and exercise on composition, structural maturation and appearance of osteoarthritis in articular cartilage of hamsters.
Journal of anatomy 2010;217(3):262-74.
2010: Petro Julkunen; J Iivarinen; P A Brama; Jari P A Arokoski; Jukka S Jurvelin; Heikki J Helminen
Maturation of collagen fibril network structure in tibial and femoral cartilage of rabbits.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(3):406-15.
2010: Teemu K Långsjö; Anna I Vasara; Mika M Hyttinen; Mikko Juhani Lammi; Antti Kaukinen; Heikki J Helminen; Ilkka Kiviranta
Quantitative analysis of collagen network structure and fibril dimensions in cartilage repair with autologous chondrocyte transplantation.
Cells, tissues, organs 2010;192(6):351-60.
2009: Petro Julkunen; T Harjula; J Iivarinen; J Marjanen; K Seppänen; T Närhi; Jari P A Arokoski; Mikko Juhani Lammi; P A Brama; Jukka S Jurvelin; Heikki J Helminen
Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(12):1628-38.
2009: Mika M Hyttinen; Jaakko Holopainen; P René van Weeren; Elwyn C Firth; Heikki J Helminen; Pieter A J Brama
Changes in collagen fibril network organization and proteoglycan distribution in equine articular cartilage during maturation and growth.
Journal of anatomy 2009;215(5):584-91.
2009: Hanna Isaksson; Viivi Tolvanen; Mikko A J Finnilä; Jarkko Iivarinen; Antti Turunen; Tuomo S Silvast; Juha Tuukkanen; Kari Seppänen; Jari P A Arokoski; Pieter A Brama; Jukka S Jurvelin; Heikki J Helminen
Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix.
Experimental gerontology 2009;44(11):708-17.
2009: Hanna Isaksson; Viivi Tolvanen; Mikko A J Finnilä; Jarkko Iivarinen; Juha Tuukkanen; Kari Seppänen; Jari P A Arokoski; Pieter A Brama; Jukka S Jurvelin; Heikki J Helminen
Physical exercise improves properties of bone and its collagen network in growing and maturing mice.
Calcified tissue international 2009;85(3):247-56.
2009: Pieter A J Brama; Jaakko Holopainen; P René Van Weeren; Elwyn C Firth; Heikki J Helminen; Mika M Hyttinen
Effect of loading on the organization of the collagen fibril network in juvenile equine articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(9):1226-34.
2009: P A J Brama; E C Firth; P René Van Weeren; J Tuukkanen; J Holopainen; Heikki J Helminen; Mika M Hyttinen
Influence of intensity and changes of physical activity on bone mineral density of immature equine subchondral bone.
Equine veterinary journal 2009;41(6):564-71.
2009: P A J Brama; J Holopainen; P René Van Weeren; E C Firth; Heikki J Helminen; Mika M Hyttinen
Influence of exercise and joint topography on depth-related spatial distribution of proteoglycan and collagen content in immature equine articular cartilage.
Equine veterinary journal 2009;41(6):557-63.
2009: Heikki J Helminen
Sports, loading of cartilage, osteoarthritis and its prevention.
Scandinavian journal of medicine & science in sports 2009;19(2):143-5.
2009: Jarno Rieppo; Mika M Hyttinen; E Halmesmaki; H Ruotsalainen; Anna I Vasara; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen
Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(4):448-55.
2009: Petro Julkunen; Terhi Harjula; Juho Marjanen; Heikki J Helminen; Jukka S Jurvelin
Comparison of single-phase isotropic elastic and fibril-reinforced poroelastic models for indentation of rabbit articular cartilage.
Journal of biomechanics 2009;42(5):652-6.
2009: Teemu K Långsjö; Machiko Arita; Heikki J Helminen
Cartilage collagen fibril network in newborn transgenic mice analyzed by electron microscopic stereology.
Cells, tissues, organs 2009;190(4):209-18.
2008: Jaakko T Holopainen; Pieter A J Brama; Esa Halmesmäki; Terhi Harjula; Juha Tuukkanen; P René Van Weeren; Heikki J Helminen; Mika M Hyttinen
Changes in subchondral bone mineral density and collagen matrix organization in growing horses.
Bone 2008;43(6):1108-14.
2008: Jarno Rieppo; Jarmo Hallikainen; Jukka S Jurvelin; Ilkka Kiviranta; Heikki J Helminen; Mika M Hyttinen
Practical considerations in the use of polarized light microscopy in the analysis of the collagen network in articular cartilage.
Microscopy research and technique 2008;71(4):279-87.
2008: Jyrki Nieminen; Janne Sahlman; Teemu Hirvonen; Tuomo Lapveteläinen; Markku Miettinen; Ilkka Arnala; Hartmut H Malluche; Heikki J Helminen
Disturbed synthesis of type II collagen interferes with rate of bone formation and growth and increases bone resorption in transgenic mice.
Calcified tissue international 2008;82(3):229-37.
2007: Gregory D Jay; Jahn R Torres; David K Rhee; Heikki J Helminen; Mika M Hytinnen; Chung-Ja Cha; Khaled A Elsaid; Kyung-Suk Kim; Yajun Cui; Matthew L Warman
Association between friction and wear in diarthrodial joints lacking lubricin.
Arthritis and rheumatism 2007;56(11):3662-9.
2007: Cheng-Juan Qu; M Jauhiainen; S Auriola; Heikki J Helminen; Mikko Juhani Lammi
Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(7):773-9.
2007: Tuomas Liikavainio; Juha Isolehto; Heikki J Helminen; Jarmo Perttunen; Vesa Lepola; Ilkka Kiviranta; Jari P A Arokoski; Paavo V Komi
Loading and gait symmetry during level and stair walking in asymptomatic subjects with knee osteoarthritis: importance of quadriceps femoris in reducing impact force during heel strike?
The Knee 2007;14(3):231-8.
2006: Anna I Vasara; Mika M Hyttinen; O Pulliainen; Mikko Juhani Lammi; Jukka S Jurvelin; L Peterson; A Lindahl; Heikki J Helminen; Ilkka Kiviranta
Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(10):1066-74.
2006: Kai Kaarniranta; Tapio Ihanamäki; Janne Sahlman; Hertta Pulkkinen; Hannu Uusitalo; Machiko Arita; Raija Tammi; Mikko Juhani Lammi; Heikki J Helminen
A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).
Experimental eye research 2006;83(2):297-303.
2006: Harold Brommer; Mikko S Laasanen; P A J Brama; P René Van Weeren; Heikki J Helminen; Jukka S Jurvelin
In situ and ex vivo evaluation of an arthroscopic indentation instrument to estimate the health status of articular cartilage in the equine metacarpophalangeal joint.
Veterinary surgery : VS 2006;35(3):259-66.
2006: Cheng-Juan Qu; Hannu M Karjalainen; Heikki J Helminen; Mikko Juhani Lammi
The lack of effect of glucosamine sulphate on aggrecan mRNA expression and (35)S-sulphate incorporation in bovine primary chondrocytes.
Biochimica et biophysica acta 2006;1762(4):453-9.
2005: Harold Brommer; Mikko S Laasanen; P A J Brama; P René Van Weeren; Heikki J Helminen; Jukka S Jurvelin
Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness.
Equine veterinary journal 2005;37(5):462-7.
2005: Jenni Nieminen; Janne Sahlman; T Hirvonen; T Jämsä; Juha Tuukkanen; Vuokko Kovanen; Heikki Kröger; Jukka S Jurvelin; Machiko Arita; Shi-Wu Li; Darwin J Prockop; Mika M Hyttinen; Heikki J Helminen; T Lapveteläinen; Kaija Puustjärvi
Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice.
Calcified tissue international 2005;77(2):104-12.
2005: Harold Brommer; Mikko S Laasanen; P A J Brama; P René Van Weeren; Ab Barneveld; Heikki J Helminen; Jukka S Jurvelin
Influence of age, site, and degenerative state on the speed of sound in equine articular cartilage.
American journal of veterinary research 2005;66(7):1175-80.
2005: Mika A Elo; Kai Kaarniranta; Heikki J Helminen; Mikko Juhani Lammi
Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure.
Biochimica et biophysica acta 2005;1743(1-2):115-9.
2005: Harold Brommer; P A J Brama; Mikko S Laasanen; Heikki J Helminen; P René Van Weeren; Jukka S Jurvelin
Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis.
Equine veterinary journal 2005;37(2):148-54.
2005: Mika A Elo; Hannu M Karjalainen; Reijo K Sironen; Leena Valmu; Nicholas T Redpath; Gareth J Browne; Nisse Kalkkinen; Heikki J Helminen; Mikko Juhani Lammi
High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2.
Journal of cellular biochemistry 2005;94(3):497-507.
2004: Janne Sahlman; Marja T Pitkänen; Darwin J Prockop; Machiko Arita; Shi-Wu Li; Heikki J Helminen; Teemu K Långsjö; Kaija Puustjärvi; Mikko Juhani Lammi
A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice.
Arthritis and rheumatism 2004;50(10):3153-60.
2004: Reijo K Sironen; Hannu M Karjalainen; Kari Törrönen; Mika A Elo; Mika M Hyttinen; Heikki J Helminen; Mikko Juhani Lammi
Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization.
The international journal of biochemistry & cell biology 2004;36(8):1521-31.
2004: M Kopakkala-Tani; Mika A Elo; Reijo K Sironen; Heikki J Helminen; Mikko Juhani Lammi
High hydrostatic pressure induces ERK and PI3 kinase phosphorylation in human HCS-2/8 chondrosarcoma cells.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(4):485-90.
2004: Merja H Arokoski; Mikko Haara; Heikki J Helminen; Jari P A Arokoski
Physical function in men with and without hip osteoarthritis.
Archives of physical medicine and rehabilitation 2004;85(4):574-81.
2004: Miika T Nieminen; Juha Töyräs; Mikko S Laasanen; Johanna Silvennoinen; Heikki J Helminen; Jukka S Jurvelin
Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging.
Journal of biomechanics 2004;37(3):321-8.
2004: Olli Mäkelä; Mikko Juhani Lammi; Hannele Uusitalo; Minna Viitanen; Mika M Hyttinen; Jukka S Jurvelin; Eero Vuorio; Heikki J Helminen; Riitta-Mari Tulamo
Effect of radiosynovectomy with holmium-166 ferric hydroxide macroaggregate on adult equine cartilage.
The Journal of rheumatology 2004;31(2):321-8.
2004: Mikko Juhani Lammi; Mika A Elo; Reijo K Sironen; Hannu M Karjalainen; Kai Kaarniranta; Heikki J Helminen
Hydrostatic pressure-induced changes in cellular protein synthesis.
Biorheology 2004;41(3-4):309-13.
2004: Jarno Rieppo; Mika M Hyttinen; Jukka S Jurvelin; Heikki J Helminen
Reference sample method reduces the error caused by variable cryosection thickness in Fourier transform infrared imaging.
Applied spectroscopy 2004;58(1):137-40.
2004: Anna I Vasara; Mika M Hyttinen; Mikko Juhani Lammi; PE Lammi; Teemu K Långsjö; Anders Lindahl; Lars Peterson; Minna Kellomäki; Yrjö T Konttinen; Heikki J Helminen; Ilkka Kiviranta
Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats.
Calcified tissue international 2004;74(1):107-14.
2003: Rami K Korhonen; Mikko S Laasanen; Juha Töyräs; Reijo Lappalainen; Heikki J Helminen; Jukka S Jurvelin
Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage.
Journal of biomechanics 2003;36(9):1373-9.
2003: Jarno Rieppo; Juha Töyräs; Miika T Nieminen; Vuokko Kovanen; Mika M Hyttinen; Rami K Korhonen; Jukka S Jurvelin; Heikki J Helminen
Structure-function relationships in enzymatically modified articular cartilage.
Cells, tissues, organs 2003;175(3):121-32.
2003: Olli Mäkelä; Mikko Juhani Lammi; H Uusitalo; Mika M Hyttinen; Eero Vuorio; Heikki J Helminen; Riitta-Mari Tulamo
Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate.
Annals of the rheumatic diseases 2003;62(1):43-9.
2003: Mika A Elo; Reijo K Sironen; Hannu M Karjalainen; Kai Kaarniranta; Heikki J Helminen; Mikko Juhani Lammi
Specific induction of heat shock protein 90beta by high hydrostatic pressure.
Biorheology 2003;40(1-3):141-6.
2003: Hannu M Karjalainen; Reijo K Sironen; Mika A Elo; Kai Kaarniranta; Masaharu Takigawa; Heikki J Helminen; Mikko Juhani Lammi
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study.
Biorheology 2003;40(1-3):93-100.
2003: Kai Kaarniranta; Mika A Elo; Reijo K Sironen; Hannu M Karjalainen; Heikki J Helminen; Mikko Juhani Lammi
Stress responses of mammalian cells to high hydrostatic pressure.
Biorheology 2003;40(1-3):87-92.
2002: Merja H Arokoski; Jari P A Arokoski; Mikko Haara; Markku Kankaanpää; Minna Vesterinen; Lea H Niemitukia; Heikki J Helminen
Hip muscle strength and muscle cross sectional area in men with and without hip osteoarthritis.
The Journal of rheumatology 2002;29(10):2185-95.
2002: Miika T Nieminen; Jarno Rieppo; Johanna Silvennoinen; Juha Töyräs; Juhana M Hakumäki; Mika M Hyttinen; Heikki J Helminen; Jukka S Jurvelin
Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;48(4):640-8.
2002: T Lapveteläinen; Mika M Hyttinen; Anna-Marja Säämänen; Teemu K Långsjö; Janne Sahlman; S Felszeghy; Eero Vuorio; Heikki J Helminen
Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice.
Annals of the rheumatic diseases 2002;61(9):810-7.
2002: Reijo K Sironen; Hannu M Karjalainen; Mika A Elo; Kai Kaarniranta; Kari Törrönen; Masaharu Takigawa; Heikki J Helminen; Mikko Juhani Lammi
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure.
Biochimica et biophysica acta 2002;1591(1-3):45-54.
2002: Heikki J Helminen; Anna-Marja Säämänen; Heli Salminen; Mika M Hyttinen
Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis.
Rheumatology (Oxford, England) 2002;41(8):848-56.
2002: Rami K Korhonen; Mikko S Laasanen; Juha Töyräs; Jarno Rieppo; Jani Hirvonen; Heikki J Helminen; Jukka S Jurvelin
Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation.
Journal of biomechanics 2002;35(7):903-9.
2002: Kai Kaarniranta; Niku K J Oksala; Hannu M Karjalainen; Tiina Suuronen; Lea Sistonen; Heikki J Helminen; Antero Salminen; Mikko Juhani Lammi
Neuronal cells show regulatory differences in the hsp70 gene response.
Brain research. Molecular brain research 2002;101(1-2):136-40.
2002: Rami K Korhonen; M Wong; Jari P A Arokoski; R Lindgren; Heikki J Helminen; E B Hunziker; Jukka S Jurvelin
Importance of the superficial tissue layer for the indentation stiffness of articular cartilage.
Medical engineering & physics 2002;24(2):99-108.
2002: Jari P A Arokoski; Merja H Arokoski; Jukka S Jurvelin; Heikki J Helminen; Lea H Niemitukia; Heikki Kröger
Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis.
Annals of the rheumatic diseases 2002;61(2):145-50.
2002: Teemu K Långsjö; Jarno Rieppo; Alpo Pelttari; Niku K J Oksala; Vuokko Kovanen; Heikki J Helminen
Collagenase-induced changes in articular cartilage as detected by electron-microscopic stereology, quantitative polarized light microscopy and biochemical assays.
Cells, tissues, organs 2002;172(4):265-75.
2002: Juha Töyräs; Heikki J Nieminen; Mikko S Laasanen; Miika T Nieminen; Rami K Korhonen; Jarno Rieppo; Jani Hirvonen; Heikki J Helminen; Jukka S Jurvelin
Ultrasonic characterization of articular cartilage.
Biorheology 2002;39(1-2):161-9.
2002: Reijo K Sironen; Hannu M Karjalainen; Kari Törrönen; Mika A Elo; Kai Kaarniranta; Masaharu Takigawa; Heikki J Helminen; Mikko Juhani Lammi
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis.
Biorheology 2002;39(1-2):111-7.
2001: Janne Sahlman; RI Inkinen; T Hirvonen; Mikko Juhani Lammi; PE Lammi; Jenni Nieminen; T Lapveteläinen; Darwin J Prockop; Machiko Arita; Shi-Wu Li; Mika M Hyttinen; Heikki J Helminen; Kaija Puustjärvi
Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen.
Spine 2001;26(23):2558-65.
2001: Mika M Hyttinen; Jari P A Arokoski; Jyrki Parkkinen; Mikko Juhani Lammi; T Lapveteläinen; K Mauranen; K Király; Markku Tammi; Heikki J Helminen
Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(8):694-701.
2001: M M Espanha; PE Lammi; Mika M Hyttinen; Mikko Juhani Lammi; Heikki J Helminen
Extracellular matrix composition of full-thickness defect repair tissue is little influenced by exercise in rat articular cartilage.
Connective tissue research 2001;42(2):97-109.
2001: Merja Suominen; Riitta-Mari Tulamo; M O Anttila; Satu Sankari; K Király; T Lapveteläinen; Heikki J Helminen
Effects of intra-articular injections of bufexamac suspension in healthy horses.
American journal of veterinary research 2001;62(10):1629-35.
2001: Miika T Nieminen; Jarno Rieppo; Juha Töyräs; Juhana M Hakumäki; Johanna Silvennoinen; Mika M Hyttinen; Heikki J Helminen; Jukka S Jurvelin
T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):487-93.
2001: Mika M Hyttinen; Juha Töyräs; T Lapveteläinen; J Lindblom; Darwin J Prockop; Shi-Wu Li; Machiko Arita; Jukka S Jurvelin; Heikki J Helminen
Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer.
Annals of the rheumatic diseases 2001;60(3):262-8.
2001: T Lapveteläinen; Mika M Hyttinen; J Lindblom; Teemu K Långsjö; Reijo K Sironen; Shi-Wu Li; Machiko Arita; Darwin J Prockop; Kaija Puustjärvi; Heikki J Helminen
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):152-60.
2001: Kai Kaarniranta; Niku K J Oksala; Mikko Juhani Lammi; Heikki J Helminen; Lea Sistonen
[From research of cellular stress to various clinical break through innovations?].
Duodecim; lääketieteellinen aikakauskirja 2001;117(22):2266-72.
2001: Jari P A Arokoski; Mikko Juhani Lammi; Mika M Hyttinen; Ilkka Kiviranta; Jyrki Parkkinen; J S Jurvelin; Markku Tammi; Heikki J Helminen
[Etiopathogenesis of osteoarthritis].
Duodecim; lääketieteellinen aikakauskirja 2001;117(16):1617-26; quiz 1626, 1679.
2001: Kai Kaarniranta; C I Holmberg; Mikko Juhani Lammi; John E Eriksson; Lea Sistonen; Heikki J Helminen
Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):7-13.
2001: J Haapala; Jari P A Arokoski; Seppo Rönkkö; UM Agren; Veli-Matti Kosma; LS Lohmander; Markku Tammi; Heikki J Helminen; Ilkka Kiviranta
Decline after immobilisation and recovery after remobilisation of synovial fluid IL1, TIMP, and chondroitin sulphate levels in young beagle dogs.
Annals of the rheumatic diseases 2001;60(1):55-60.
2000: Mika A Elo; Reijo K Sironen; Kai Kaarniranta; S Auriola; Heikki J Helminen; Mikko Juhani Lammi
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytic cells.
Journal of cellular biochemistry 2000;79(4):610-9.
2000: Jari P A Arokoski; Jukka S Jurvelin; U Väätäinen; Heikki J Helminen
Normal and pathological adaptations of articular cartilage to joint loading.
Scandinavian journal of medicine & science in sports 2000;10(4):186-98.
2000: Kai Kaarniranta; C I Holmberg; Heikki J Helminen; John E Eriksson; Lea Sistonen; Mikko Juhani Lammi
Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature.
FEBS letters 2000;475(3):283-6.
2000: Jukka S Jurvelin; J P Arokoski; E B Hunziker; Heikki J Helminen
Topographical variation of the elastic properties of articular cartilage in the canine knee.
Journal of biomechanics 2000;33(6):669-75.
2000: Miika T Nieminen; Juha Töyräs; Jarno Rieppo; Juhana M Hakumäki; Johanna Silvennoinen; Heikki J Helminen; Jukka S Jurvelin
Quantitative MR microscopy of enzymatically degraded articular cartilage.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;43(5):676-81.
2000: Heikki J Helminen; Mika M Hyttinen; Mikko Juhani Lammi; Jari P A Arokoski; T Lapveteläinen; Jukka S Jurvelin; Ilkka Kiviranta; Markku Tammi
Regular joint loading in youth assists in the establishment and strengthening of the collagen network of articular cartilage and contributes to the prevention of osteoarthrosis later in life: a hypothesis.
Journal of bone and mineral metabolism 2000;18(5):245-57.
2000: Reijo K Sironen; Mika A Elo; Kai Kaarniranta; Heikki J Helminen; Mikko Juhani Lammi
Transcriptional activation in chondrocytes submitted to hydrostatic pressure.
Biorheology 2000;37(1-2):85-93.
2000: J Haapala; Jari P A Arokoski; J Pirttimäki; T Lyyra; Jukka S Jurvelin; Markku Tammi; Heikki J Helminen; Ilkka Kiviranta
Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization.
International journal of sports medicine 2000;21(1):76-81.
1999: Juha Töyräs; Jarno Rieppo; Miika T Nieminen; Heikki J Helminen; Jukka S Jurvelin
Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound.
Physics in medicine and biology 1999;44(11):2723-33.
1999: Teemu K Långsjö; Mika M Hyttinen; Alpo Pelttari; K Kiraly; Jari P A Arokoski; Heikki J Helminen
Electron microscopic stereological study of collagen fibrils in bovine articular cartilage: volume and surface densities are best obtained indirectly (from length densities and diameters) using isotropic uniform random sampling.
Journal of anatomy 1999;195 ( Pt 2)():281-93.
1999: Mikko Harri; J Lindblom; H Malinen; Mika M Hyttinen; T Lapveteläinen; S Eskola; Heikki J Helminen
Effect of access to a running wheel on behavior of C57BL/6J mice.
Laboratory animal science 1999;49(4):401-5.
1999: J Haapala; Jari P A Arokoski; Mika M Hyttinen; Mikko Juhani Lammi; Markku Tammi; Vuokko Kovanen; Heikki J Helminen; Ilkka Kiviranta
Remobilization does not fully restore immobilization induced articular cartilage atrophy.
Clinical orthopaedics and related research 1999;(362):218-29.
1999: Kaija Puustjärvi; Jenni Nieminen; Tuomas Räsänen; Mika M Hyttinen; Heikki J Helminen; Heikki Kröger; J Huuskonen; E Alhava; Vuokko Kovanen
Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(3):321-9.
1999: T Lyyra; Ilkka Kiviranta; U Väätäinen; Heikki J Helminen; Jukka S Jurvelin
In vivo characterization of indentation stiffness of articular cartilage in the normal human knee.
Journal of biomedical materials research 1999;48(4):482-7.
1999: Jari P A Arokoski; Mika M Hyttinen; Heikki J Helminen; Jukka S Jurvelin
Biomechanical and structural characteristics of canine femoral and tibial cartilage.
Journal of biomedical materials research 1999;48(2):99-107.
1998: K Király; Mika M Hyttinen; Jyrki Parkkinen; J A Arokoski; T Lapveteläinen; Kari Törrönen; Ilkka Kiviranta; Heikki J Helminen
Articular cartilage collagen birefringence is altered concurrent with changes in proteoglycan synthesis during dynamic in vitro loading.
The Anatomical record 1998;251(1):28-36.
1998: HE Panula; Mika M Hyttinen; Jari P A Arokoski; Teemu K Långsjö; Alpo Pelttari; Ilkka Kiviranta; Heikki J Helminen
Articular cartilage superficial zone collagen birefringence reduced and cartilage thickness increased before surface fibrillation in experimental osteoarthritis.
Annals of the rheumatic diseases 1998;57(4):237-45.
1998: HE Panula; LS Lohmander; Seppo Rönkkö; UM Agren; Heikki J Helminen; Ilkka Kiviranta
Elevated levels of synovial fluid PLA2, stromelysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs.
Acta orthopaedica Scandinavica 1998;69(2):152-8.
1998: Kai Kaarniranta; Mika A Elo; Reijo K Sironen; Mikko Juhani Lammi; M B Goldring; John E Eriksson; Lea Sistonen; Heikki J Helminen
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2319-24.
1997: HE Panula; Heikki J Helminen; Ilkka Kiviranta
Slowly progressive osteoarthritis after tibial valgus osteotomy in young beagle dogs.
Clinical orthopaedics and related research 1997;(343):192-202.
1997: K Király; Mika M Hyttinen; T Lapveteläinen; Mika A Elo; Ilkka Kiviranta; J Dobai; L Módis; Heikki J Helminen; Jari P A Arokoski
Specimen preparation and quantification of collagen birefringence in unstained sections of articular cartilage using image analysis and polarizing light microscopy.
The Histochemical journal 1997;29(4):317-27.
1997: M O Jortikka; RI Inkinen; Markku Tammi; Jyrki Parkkinen; J Haapala; Ilkka Kiviranta; Heikki J Helminen; Mikko Juhani Lammi
Immobilisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage.
Annals of the rheumatic diseases 1997;56(4):255-61.
1997: T Lapveteläinen; A Tiihonen; P Koskela; Timo Nevalainen; J Lindblom; K Király; P Halonen; Heikki J Helminen
Training a large number of laboratory mice using running wheels and analyzing running behavior by use of a computer-assisted system.
Laboratory animal science 1997;47(2):172-9.
1996: J Haapala; Mikko Juhani Lammi; RI Inkinen; Jyrki Parkkinen; UM Agren; Jari P A Arokoski; Ilkka Kiviranta; Heikki J Helminen; Markku Tammi
Coordinated regulation of hyaluronan and aggrecan content in the articular cartilage of immobilized and exercised dogs.
The Journal of rheumatology 1996;23(9):1586-93.
1996: K Király; T Lapveteläinen; Jari P A Arokoski; K Törrönen; L Módis; Ilkka Kiviranta; Heikki J Helminen
Application of selected cationic dyes for the semiquantitative estimation of glycosaminoglycans in histological sections of articular cartilage by microspectrophotometry.
The Histochemical journal 1996;28(8):577-90.
1996: Jari P A Arokoski; Mika M Hyttinen; T Lapveteläinen; P Takács; B Kosztáczky; L Módis; Vuokko Kovanen; Heikki J Helminen
Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy.
Annals of the rheumatic diseases 1996;55(4):253-64.
1996: Jyrki Parkkinen; Tomi P Häkkinen; S Savolainen; C Wang; Raija Tammi; UM Agren; Mikko Juhani Lammi; Jari P A Arokoski; Heikki J Helminen; Markku Tammi
Distribution of hyaluronan in articular cartilage as probed by a biotinylated binding region of aggrecan.
Histochemistry and cell biology 1996;105(3):187-94.
1996: K Király; Mikko Juhani Lammi; Jari P A Arokoski; T Lapveteläinen; Markku Tammi; Heikki J Helminen; Ilkka Kiviranta
Safranin O reduces loss of glycosaminoglycans from bovine articular cartilage during histological specimen preparation.
The Histochemical journal 1996;28(2):99-107.
1996: L Módis; A Botos; Ilkka Kiviranta; L Lukácskó; Heikki J Helminen
Differences in submicroscopic structure of the extracellular matrix of canine femoral and tibial condylar articular cartilages as revealed by polarization microscopical analysis.
Acta biologica Hungarica 1996;47(1-4):341-53.
1995: S W Li; D J Prockop; Heikki J Helminen; R Fässler; T Lapveteläinen; K Kiraly; A Peltarri; Jari P A Arokoski; H Lui; M Arita
Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone.
Genes & development 1995;9(22):2821-30.
1995: Jyrki Parkkinen; Mikko Juhani Lammi; RI Inkinen; M Jortikka; Markku Tammi; I Virtanen; Heikki J Helminen
Influence of short-term hydrostatic pressure on organization of stress fibers in cultured chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(4):495-502.
1995: T Lapveteläinen; Tapio Nevalainen; Jyrki Parkkinen; Jari P A Arokoski; K Kiraly; Mika M Hyttinen; P Halonen; Heikki J Helminen
Lifelong moderate running training increases the incidence and severity of osteoarthritis in the knee joint of C57BL mice.
The Anatomical record 1995;242(2):159-65.
1995: Kaija Puustjärvi; R Lappalainen; L Niemitukia; I Arnala; J Nieminen; Markku Tammi; Heikki J Helminen
Long-distance running alters bone anthropometry, elemental composition and mineral density of young dogs.
Scandinavian journal of medicine & science in sports 1995;5(1):17-23.
1994: Jari P A Arokoski; Jukka S Jurvelin; Ilkka Kiviranta; Markku Tammi; Heikki J Helminen
Softening of the lateral condyle articular cartilage in the canine knee joint after long distance (up to 40 km/day) running training lasting one year.
International journal of sports medicine 1994;15(5):254-60.
1994: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Jari P A Arokoski; Anna-Marja Säämänen; Heikki J Helminen
Articular cartilage thickness and glycosaminoglycan distribution in the young canine knee joint after remobilization of the immobilized limb.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):161-7.
1994: Pentti Mäntymaa; Jari P A Arokoski; Ilkka Pörsti; M Perhonen; Pertti Arvola; Heikki J Helminen; T E S Takala; Juhani Leppäluoto; Heikki Ruskoaho
Effect of endurance training on atrial natriuretic peptide gene expression in normal and hypertrophied hearts.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1184-94.
1994: Kaija Puustjärvi; Mikko Juhani Lammi; Heikki J Helminen; RI Inkinen; Markku Tammi
Proteoglycans in the intervertebral disc of young dogs following strenuous running exercise.
Connective tissue research 1994;30(3):225-40.
1994: Kaija Puustjärvi; Markku Tammi; M Reinikainen; Heikki J Helminen; L Paljärvi
Running training alters fiber type composition in spinal muscles.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 1994;3(1):17-21.
1993: Darwin J Prockop; A Colige; Heikki J Helminen; Jaspal Singh Khillan; R Pereira; P Vandenberg
Mutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8 Suppl 2():S489-92.
1993: Kaija Puustjärvi; T Takala; W Wang; Markku Tammi; Heikki J Helminen; V Kovanen
Enhanced prolylhydroxylase activity in the posterior annulus fibrosus of canine intervertebral discs following long-term running exercise.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 1993;2(3):126-31.
1993: Jari P A Arokoski; Ilkka Kiviranta; Jukka S Jurvelin; Markku Tammi; Heikki J Helminen
Long-distance running causes site-dependent decrease of cartilage glycosaminoglycan content in the knee joints of beagle dogs.
Arthritis and rheumatism 1993;36(10):1451-9.
1993: Kaija Puustjärvi; Mikko Juhani Lammi; Ilkka Kiviranta; Heikki J Helminen; Markku Tammi
Proteoglycan synthesis in canine intervertebral discs after long-distance running training.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1993;11(5):738-46.
1993: Heikki J Helminen; K Kiraly; Alpo Pelttari; Markku Tammi; P Vandenberg; R Pereira; R Dhulipala; Jaspal Singh Khillan; Leena Ala-Kokko; Eric L Hume
An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.
The Journal of clinical investigation 1993;92(2):582-95.
1993: Mikko Juhani Lammi; Tomi P Häkkinen; Jyrki Parkkinen; Mika M Hyttinen; M Jortikka; Heikki J Helminen; Markku Tammi
Adaptation of canine femoral head articular cartilage to long distance running exercise in young beagles.
Annals of the rheumatic diseases 1993;52(5):369-77.
1993: Jyrki Parkkinen; Mikko Juhani Lammi; Alpo Pelttari; Heikki J Helminen; Markku Tammi; I Virtanen
Altered Golgi apparatus in hydrostatically loaded articular cartilage chondrocytes.
Annals of the rheumatic diseases 1993;52(3):192-8.
1993: R Pereira; Jaspal Singh Khillan; Heikki J Helminen; Eric L Hume; Darwin J Prockop
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.
The Journal of clinical investigation 1993;91(2):709-16.
1993: Kaija Puustjärvi; Mikko Juhani Lammi; Ilkka Kiviranta; Heikki J Helminen; Markku Tammi
Flat bed scanner in the quantitative assay of 35SO4-incorporation by X-ray film autoradiography of intervertebral disc sections.
Histochemistry 1993;99(1):67-73.
1993: Mikko Juhani Lammi; Tomi P Häkkinen; Jyrki Parkkinen; Mika M Hyttinen; M Jortikka; Heikki J Helminen; Markku Tammi
Effects of long-term running exercise on canine femoral head articular cartilage.
Agents and actions. Supplements 1993;39():95-9.
1993: Anna-Marja Säämänen; Kaija Puustjärvi; K Ilves; Mikko Juhani Lammi; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen; Markku Tammi
Effect of running exercise on proteoglycans and collagen content in the intervertebral disc of young dogs.
International journal of sports medicine 1993;14(1):48-51.
1993: Jyrki Parkkinen; J Ikonen; Mikko Juhani Lammi; J Laakkonen; Markku Tammi; Heikki J Helminen
Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants.
Archives of biochemistry and biophysics 1993;300(1):458-65.
1993: Jari P A Arokoski; P V Miettinen; Anna-Marja Säämänen; K Haapanen; Markku Parviainen; Markku Tammi; Heikki J Helminen
Effects of aerobic long distance running training (up to 40 km.day-1) of 1-year duration on blood and endocrine parameters of female beagle dogs.
European journal of applied physiology and occupational physiology 1993;67(4):321-9.
1992: R Oettmeier; Jari P A Arokoski; A J Roth; Heikki J Helminen; M Tammi; K Abendroth
Quantitative study of articular cartilage and subchondral bone remodeling in the knee joint of dogs after strenuous running training.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7 Suppl 2():S419-24.
1992: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Jari P A Arokoski; Anna-Marja Säämänen; Heikki J Helminen
Articular cartilage thickness and glycosaminoglycan distribution in the canine knee joint after strenuous running exercise.
Clinical orthopaedics and related research 1992;(283):302-8.
1992: Jyrki Parkkinen; Mikko Juhani Lammi; Heikki J Helminen; Markku Tammi
Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1992;10(5):610-20.
1992: Kaija Puustjärvi; P Karjalainen; J Nieminen; Jari P A Arokoski; Markku Parviainen; Heikki J Helminen; S Soimakallio
Endurance training associated with slightly lowered serum estradiol levels decreases mineral density of canine skeleton.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(6):619-24.
1992: Heikki J Helminen; Anna-Marja Säämänen; Jukka S Jurvelin; Ilkka Kiviranta; Jyrki Parkkinen; Mikko Juhani Lammi; Markku Tammi
[The effect of loading on articular cartilage].
Duodecim; lääketieteellinen aikakauskirja 1992;108(12):1097-107.
1991: P Vandenberg; Jaspal Singh Khillan; Darwin J Prockop; Heikki J Helminen; S Kontusaari; Leena Ala-Kokko
Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7640-4.
1991: Jari P A Arokoski; Ilkka Kiviranta; J Laakkonen; A Tiihonen; E Sopanen; J Ikonen; Tapio Nevalainen; K Haapanen; Markku Tammi; Heikki J Helminen
A ten-track treadmill for running training of dogs.
Laboratory animal science 1991;41(3):246-50.
1991: Kaija Puustjärvi; P Karjalainen; J Nieminen; Heikki J Helminen; S Soimakallio; T Kivimäki; Jari P A Arokoski
Effects of long-term running on spinal mineral content in dogs.
Calcified tissue international 1991;49 Suppl():S81-2.
1990: Anna-Marja Säämänen; Markku Tammi; Jukka S Jurvelin; Ilkka Kiviranta; Heikki J Helminen
Proteoglycan alterations following immobilization and remobilization in the articular cartilage of young canine knee (stifle) joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1990;8(6):863-73.
1990: Jyrki Parkkinen; K Paukkonen; E Pesonen; Mikko Juhani Lammi; S Markkanen; Heikki J Helminen; Markku Tammi
Quantitation of autoradiographic grains in different zones of articular cartilage with image analyzer.
Histochemistry 1990;93(3):241-5.
1990: Jukka S Jurvelin; Ilkka Kiviranta; Anna-Marja Säämänen; Markku Tammi; Heikki J Helminen
Indentation stiffness of young canine knee articular cartilage--influence of strenuous joint loading.
Journal of biomechanics 1990;23(12):1239-46.
1989: Anna-Marja Säämänen; Markku Tammi; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen
Levels of chondroitin-6-sulfate and nonaggregating proteoglycans at articular cartilage contact sites in the knees of young dogs subjected to moderate running exercise.
Arthritis and rheumatism 1989;32(10):1282-92.
1989: Jukka S Jurvelin; Ilkka Kiviranta; Anna-Marja Säämänen; Markku Tammi; Heikki J Helminen
Partial restoration of immobilization-induced softening of canine articular cartilage after remobilization of the knee (stifle) joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(3):352-8.
1989: Jyrki Parkkinen; Mikko Juhani Lammi; S Karjalainen; J Laakkonen; E Hyvärinen; A Tiihonen; Heikki J Helminen; Markku Tammi
A mechanical apparatus with microprocessor controlled stress profile for cyclic compression of cultured articular cartilage explants.
Journal of biomechanics 1989;22(11-12):1285-91.
1988: Anna-Marja Säämänen; Markku Tammi; Ilkka Kiviranta; Heikki J Helminen
Running exercise as a modulatory of proteoglycan matrix in the articular cartilage of young rabbits.
International journal of sports medicine 1988;9(2):127-33.
1988: Jukka S Jurvelin; Tapani Lahtinen; Ilkka Kiviranta; I Arnala; R Lappalainen; Markku Tammi; Heikki J Helminen
Blood flow, histomorphology and elemental composition of the canine femur after physical training or immobilization.
Acta physiologica Scandinavica 1988;132(3):385-9.
1988: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Anna-Marja Säämänen; Heikki J Helminen
Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(2):188-95.
1988: Markku Tammi; Ilkka Kiviranta; L Peltonen; Jukka S Jurvelin; Heikki J Helminen
Effects of joint loading on articular cartilage collagen metabolism: assay of procollagen prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase.
Connective tissue research 1988;17(3):199-206.
1987: K Paukkonen; Heikki J Helminen
Chondrocyte ultrastructure in exercise and experimental osteoarthrosis. A stereologic morphometric study of articular cartilage of young rabbits using transmission electron microscopy.
Clinical orthopaedics and related research 1987;(224):284-8.
1987: K Paukkonen; Heikki J Helminen
Decrease of proteoglycan granule number but increase of their size in articular cartilage of young rabbits after physical exercise and immobilization by splinting.
The Anatomical record 1987;219(1):45-52.
1987: Ilkka Kiviranta; Jukka S Jurvelin; Markku Tammi; Anna-Marja Säämänen; Heikki J Helminen
Weight bearing controls glycosaminoglycan concentration and articular cartilage thickness in the knee joints of young beagle dogs.
Arthritis and rheumatism 1987;30(7):801-9.
1987: K Paukkonen; Heikki J Helminen
Rough endoplasmic reticulum and fine intracytoplasmic filaments in articular cartilage chondrocytes of young rabbits; a stereological morphometric study using transmission electron microscopy.
Journal of anatomy 1987;152():47-54.
1987: Ilkka Kiviranta; M Tammi; Jukka S Jurvelin; Heikki J Helminen
Topographical variation of glycosaminoglycan content and cartilage thickness in canine knee (stifle) joint cartilage. Application of the microspectrophotometric method.
Journal of anatomy 1987;150():265-76.
1987: Anna-Marja Säämänen; Markku Tammi; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen
Maturation of proteoglycan matrix in articular cartilage under increased and decreased joint loading. A study in young rabbits.
Connective tissue research 1987;16(2):163-75.
1986: K Paukkonen; Jukka S Jurvelin; Heikki J Helminen
Effects of immobilization on the articular cartilage in young rabbits. A quantitative light microscopic stereological study.
Clinical orthopaedics and related research 1986;(206):270-80.
1985: K Paukkonen; K Selkäinaho; Jukka S Jurvelin; Ilkka Kiviranta; Heikki J Helminen
Cells and nuclei of articular cartilage chondrocytes in young rabbits enlarged after non-strenuous physical exercise.
Journal of anatomy 1985;142():13-20.
1985: Heikki J Helminen; J Jurvelin; M Tammi; Alpo Pelttari; C M Svartbäck; I Kiviranta; Anna-Marja Säämänen; K Paukkonen
Prolonged ethanol replacement by CO2 increases splits on articular cartilage surface after critical point drying.
Journal of microscopy 1985;137(Pt 3):305-12.
1985: Jukka S Jurvelin; Heikki J Helminen; S Lauritsalo; Ilkka Kiviranta; Anna-Marja Säämänen; K Paukkonen; Markku Tammi
Influences of joint immobilization and running exercise on articular cartilage surfaces of young rabbits. A semiquantitative stereomicroscopic and scanning electron microscopic study.
Acta anatomica 1985;122(1):62-8.
1985: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Anna-Marja Säämänen; Heikki J Helminen
Demonstration of chondroitin sulphate and glycoproteins in articular cartilage matrix using periodic acid-Schiff (PAS) method.
Histochemistry 1985;83(4):303-6.
1985: Ilkka Kiviranta; Jukka S Jurvelin; Markku Tammi; Anna-Marja Säämänen; Heikki J Helminen
Microspectrophotometric quantitation of glycosaminoglycans in articular cartilage sections stained with Safranin O.
Histochemistry 1985;82(3):249-55.
1984: K Paukkonen; K Selkäinaho; J Jurvelin; Heikki J Helminen
Morphometry of articular cartilage: a stereological method using light microscopy.
The Anatomical record 1984;210(4):675-82.
1984: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Anna-Marja Säämänen; Heikki J Helminen
Fixation, decalcification, and tissue processing effects on articular cartilage proteoglycans.
Histochemistry 1984;80(6):569-73.
1984: K Paukkonen; Heikki J Helminen; Markku Tammi; Jukka S Jurvelin; Ilkka Kiviranta; Anna-Marja Säämänen
Quantitative morphological and biochemical investigations on the effects of physical exercise and immobilization on the articular cartilage of young rabbits.
Acta biologica Hungarica 1984;35(2-4):293-304.
1983: Heikki J Helminen; Jukka S Jurvelin; T Kuusela; R Heikkilä; Ilkka Kiviranta; Markku Tammi
Effects of immobilization for 6 weeks on rabbit knee articular surfaces as assessed by the semiquantitative stereomicroscopic method.
Acta anatomica 1983;115(4):327-35.
1983: Heikki J Helminen; Jukka S Jurvelin; T Kuusela; R Heikkilä; Ilkka Kiviranta; Markku Tammi
Semiquantitative analysis of rabbit knee articular surfaces based on stereomicroscopic examination of the cartilage.
Acta anatomica 1983;115(4):319-26.
1983: Jukka S Jurvelin; T Kuusela; R Heikkilä; Alpo Pelttari; Ilkka Kiviranta; Markku Tammi; Heikki J Helminen
Investigation of articular cartilage surface morphology with a semiquantitative scanning electron microscopic method.
Acta anatomica 1983;116(4):302-11.
1983: Markku Tammi; Anna-Marja Säämänen; A Jauhiainen; O Malminen; Ilkka Kiviranta; Heikki J Helminen
Proteoglycan alterations in rabbit knee articular cartilage following physical exercise and immobilization.
Connective tissue research 1983;11(1):45-55.
1980: Ilkka Kiviranta; Markku Tammi; R Lappalainen; T Kuusela; Heikki J Helminen
The rate of calcium extraction during EDTA decalcification from thin bone slices as assessed with atomic absorption spectrophotometry.
Histochemistry 1980;68(2):119-27.