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Heikki Helminen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Hyttinen Mika M; Holopainen Jaakko; van Weeren P René; Firth Elwyn C; Helminen Heikki J; Brama Pieter A J
Changes in collagen fibril network organization and proteoglycan distribution in equine articular cartilage during maturation and growth.
Isaksson Hanna; Tolvanen Viivi; Finnilä Mikko A J; Iivarinen Jarkko; Turunen Antti; Silvast Tuomo S; Tuukkanen Juha; Seppänen Kari; Arokoski Jari P A; Brama Pieter A; Jurvelin Jukka S; Helminen Heikki J
Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix.
Isaksson Hanna; Tolvanen Viivi; Finnilä Mikko A J; Iivarinen Jarkko; Tuukkanen Juha; Seppänen Kari; Arokoski Jari P A; Brama Pieter A; Jurvelin Jukka S; Helminen Heikki J
Physical exercise improves properties of bone and its collagen network in growing and maturing mice.

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All Publications

2009: Hyttinen Mika M; Holopainen Jaakko; van Weeren P René; Firth Elwyn C; Helminen Heikki J; Brama Pieter A J
Changes in collagen fibril network organization and proteoglycan distribution in equine articular cartilage during maturation and growth.
Journal of anatomy 2009;215(5):584-91.
2009: Isaksson Hanna; Tolvanen Viivi; Finnilä Mikko A J; Iivarinen Jarkko; Turunen Antti; Silvast Tuomo S; Tuukkanen Juha; Seppänen Kari; Arokoski Jari P A; Brama Pieter A; Jurvelin Jukka S; Helminen Heikki J
Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix.
Experimental gerontology 2009;44(11):708-17.
2009: Isaksson Hanna; Tolvanen Viivi; Finnilä Mikko A J; Iivarinen Jarkko; Tuukkanen Juha; Seppänen Kari; Arokoski Jari P A; Brama Pieter A; Jurvelin Jukka S; Helminen Heikki J
Physical exercise improves properties of bone and its collagen network in growing and maturing mice.
Calcified tissue international 2009;85(3):247-56.
2009: Brama Pieter A J; Holopainen Jaakko; van Weeren P René; Firth Elwyn C; Helminen Heikki J; Hyttinen Mika M
Effect of loading on the organization of the collagen fibril network in juvenile equine articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(9):1226-34.
2009: Brama P A J; Firth E C; van Weeren P R; Tuukkanen J; Holopainen J; Helminen H J; Hyttinen M M
Influence of intensity and changes of physical activity on bone mineral density of immature equine subchondral bone.
Equine veterinary journal 2009;41(6):564-71.
2009: Brama P A J; Holopainen J; van Weeren P R; Firth E C; Helminen H J; Hyttinen M M
Influence of exercise and joint topography on depth-related spatial distribution of proteoglycan and collagen content in immature equine articular cartilage.
Equine veterinary journal 2009;41(6):557-63.
2009: Helminen Heikki J
Sports, loading of cartilage, osteoarthritis and its prevention.
Scandinavian journal of medicine & science in sports 2009;19(2):143-5.
2009: Rieppo J; Hyttinen M M; Halmesmaki E; Ruotsalainen H; Vasara A; Kiviranta I; Jurvelin J S; Helminen H J
Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(4):448-55.
2009: Julkunen Petro; Harjula Terhi; Marjanen Juho; Helminen Heikki J; Jurvelin Jukka S
Comparison of single-phase isotropic elastic and fibril-reinforced poroelastic models for indentation of rabbit articular cartilage.
Journal of biomechanics 2009;42(5):652-6.
2009: Långsjö Teemu K; Arita Machiko; Helminen Heikki J
Cartilage collagen fibril network in newborn transgenic mice analyzed by electron microscopic stereology.
Cells, tissues, organs 2009;190(4):209-18.
2008: Holopainen Jaakko T; Brama Pieter A J; Halmesmäki Esa; Harjula Terhi; Tuukkanen Juha; van Weeren P René; Helminen Heikki J; Hyttinen Mika M
Changes in subchondral bone mineral density and collagen matrix organization in growing horses.
Bone 2008;43(6):1108-14.
2008: Rieppo Jarno; Hallikainen Jarmo; Jurvelin Jukka S; Kiviranta Ilkka; Helminen Heikki J; Hyttinen Mika M
Practical considerations in the use of polarized light microscopy in the analysis of the collagen network in articular cartilage.
Microscopy research and technique 2008;71(4):279-87.
2008: Nieminen Jyrki; Sahlman Janne; Hirvonen Teemu; Lapveteläinen Tuomo; Miettinen Markku; Arnala Ilkka; Malluche Hartmut H; Helminen Heikki J
Disturbed synthesis of type II collagen interferes with rate of bone formation and growth and increases bone resorption in transgenic mice.
Calcified tissue international 2008;82(3):229-37.
2007: Jay Gregory D; Torres Jahn R; Rhee David K; Helminen Heikki J; Hytinnen Mika M; Cha Chung-Ja; Elsaid Khaled; Kim Kyung-Suk; Cui Yajun; Warman Matthew L
Association between friction and wear in diarthrodial joints lacking lubricin.
Arthritis and rheumatism 2007;56(11):3662-9.
2007: Qu C-J; Jauhiainen M; Auriola S; Helminen H J; Lammi M J
Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(7):773-9.
2007: Liikavainio Tuomas; Isolehto Juha; Helminen Heikki J; Perttunen Jarmo; Lepola Vesa; Kiviranta Ilkka; Arokoski Jari P A; Komi Paavo V
Loading and gait symmetry during level and stair walking in asymptomatic subjects with knee osteoarthritis: importance of quadriceps femoris in reducing impact force during heel strike?
The Knee 2007;14(3):231-8.
2006: Vasara A I; Hyttinen M M; Pulliainen O; Lammi M J; Jurvelin J S; Peterson L; Lindahl A; Helminen H J; Kiviranta I
Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(10):1066-74.
2006: Kaarniranta Kai; Ihanamäki Tapio; Sahlman Janne; Pulkkinen Hertta; Uusitalo Hannu; Arita Machiko; Tammi Raija; Lammi Mikko J; Helminen Heikki J
A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).
Experimental eye research 2006;83(2):297-303.
2006: Brommer Harold; Laasanen Mikko S; Brama Pieter A J; van Weeren P René; Helminen Heikki J; Jurvelin Jukka S
In situ and ex vivo evaluation of an arthroscopic indentation instrument to estimate the health status of articular cartilage in the equine metacarpophalangeal joint.
Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons 2006;35(3):259-66.
2006: Qu Cheng-Juan; Karjalainen Hannu M; Helminen Heikki J; Lammi Mikko J
The lack of effect of glucosamine sulphate on aggrecan mRNA expression and (35)S-sulphate incorporation in bovine primary chondrocytes.
Biochimica et biophysica acta 2006;1762(4):453-9.
2005: Brommer H; Laasanen M S; Brama P A J; van Weeren P R; Helminen H J; Jurvelin J S
Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness.
Equine veterinary journal 2005;37(5):462-7.
2005: Nieminen J; Sahlman J; Hirvonen T; Jämsä T; Tuukkanen J; Kovanen V; Kröger H; Jurvelin J; Arita M; Li S W; Prockop D J; Hyttinen M M; Helminen H J; Lapveteläinen T; Puustjärvi K
Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice.
Calcified tissue international 2005;77(2):104-12.
2005: Brommer Harold; Laasanen Mikko S; Brama Pieter A J; van Weeren P René; Barneveld Ab; Helminen Heikki J; Jurvelin Jukka S
Influence of age, site, and degenerative state on the speed of sound in equine articular cartilage.
American journal of veterinary research 2005;66(7):1175-80.
2005: Brommer H; Brama P A J; Laasanen M S; Helminen H J; van Weeren P R; Jurvelin J S
Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis.
Equine veterinary journal 2005;37(2):148-54.
2005: Elo Mika A; Kaarniranta Kai; Helminen Heikki J; Lammi Mikko J
Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure.
Biochimica et biophysica acta 2005;1743(1-2):115-9.
2005: Elo Mika A; Karjalainen Hannu M; Sironen Reijo K; Valmu Leena; Redpath Nicholas T; Browne Gareth J; Kalkkinen Nisse; Helminen Heikki J; Lammi Mikko J
High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2.
Journal of cellular biochemistry 2005;94(3):497-507.
2004: Sahlman Janne; Pitkänen Marja T; Prockop Darwin J; Arita Machiko; Li Shi-Wu; Helminen Heikki J; Långsjö Teemu K; Puustjärvi Kaija; Lammi Mikko J
A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice.
Arthritis and rheumatism 2004;50(10):3153-60.
2004: Sironen Reijo K; Karjalainen Hannu M; Törrönen Kari J; Elo Mika A; Hyttinen Mika M; Helminen Heikki J; Lammi Mikko J
Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization.
The international journal of biochemistry & cell biology 2004;36(8):1521-31.
2004: Kopakkala-Tani M; Elo M A; Sironen R K; Helminen H J; Lammi M J
High hydrostatic pressure induces ERK and PI3 kinase phosphorylation in human HCS-2/8 chondrosarcoma cells.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(4):485-90.
2004: Arokoski Merja H; Haara Mikko; Helminen Heikki J; Arokoski Jari P
Physical function in men with and without hip osteoarthritis.
Archives of physical medicine and rehabilitation 2004;85(4):574-81.
2004: Nieminen Miika T; Töyräs Juha; Laasanen Mikko S; Silvennoinen Johanna; Helminen Heikki J; Jurvelin Jukka S
Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging.
Journal of biomechanics 2004;37(3):321-8.
2004: Mäkelä Olli T; Lammi Mikko J; Uusitalo Hannele; Viitanen Minna; Hyttinen Mika M; Jurvelin Jukka S; Vuorio Eero; Helminen Heikki J; Tulamo Riitta-Mari
Effect of radiosynovectomy with holmium-166 ferric hydroxide macroaggregate on adult equine cartilage.
The Journal of rheumatology 2004;31(2):321-8.
2004: Rieppo Jarno; Hyttinen Mika M; Jurvelin Jukka S; Helminen Heikki J
Reference sample method reduces the error caused by variable cryosection thickness in Fourier transform infrared imaging.
Applied spectroscopy 2004;58(1):137-40.
2004: Vasara A I; Hyttinen M M; Lammi M J; Lammi P E; Långsjö T K; Lindahl A; Peterson L; Kellomäki M; Konttinen Y T; Helminen H J; Kiviranta I
Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats.
Calcified tissue international 2004;74(1):107-14.
2004: Lammi Mikko J; Elo Mika A; Sironen Reijo K; Karjalainen Hannu M; Kaarniranta Kai; Helminen Heikki J
Hydrostatic pressure-induced changes in cellular protein synthesis.
Biorheology 2004;41(3-4):309-13.
2003: Korhonen Rami K; Laasanen Mikko S; Töyräs Juha; Lappalainen Reijo; Helminen Heikki J; Jurvelin Jukka S
Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage.
Journal of biomechanics 2003;36(9):1373-9.
2003: Mäkelä O T; Lammi M J; Uusitalo H; Hyttinen M M; Vuorio E; Helminen H J; Tulamo R-M
Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate.
Annals of the rheumatic diseases 2003;62(1):43-9.
2003: Rieppo Jarno; Töyräs Juha; Nieminen Miika T; Kovanen Vuokko; Hyttinen Mika M; Korhonen Rami K; Jurvelin Jukka S; Helminen Heikki J
Structure-function relationships in enzymatically modified articular cartilage.
Cells, tissues, organs 2003;175(3):121-32.
2003: Elo Mika A; Sironen Reijo K; Karjalainen Hannu M; Kaarniranta Kai; Helminen Heikki J; Lammi Mikko J
Specific induction of heat shock protein 90beta by high hydrostatic pressure.
Biorheology 2003;40(1-3):141-6.
2003: Karjalainen Hannu M; Sironen Reijo K; Elo Mika A; Kaarniranta Kai; Takigawa Masaharu; Helminen Heikki J; Lammi Mikko J
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study.
Biorheology 2003;40(1-3):93-100.
2003: Kaarniranta Kai; Elo Mika A; Sironen Reijo K; Karjalainen Hannu M; Helminen Heikki J; Lammi Mikko J
Stress responses of mammalian cells to high hydrostatic pressure.
Biorheology 2003;40(1-3):87-92.
2002: Arokoski Merja H; Arokoski Jari P A; Haara Mikko; Kankaanpää Markku; Vesterinen Minna; Niemitukia Lea H; Helminen Heikki J
Hip muscle strength and muscle cross sectional area in men with and without hip osteoarthritis.
The Journal of rheumatology 2002;29(10):2185-95.
2002: Nieminen Miika T; Rieppo Jarno; Silvennoinen Johanna; Töyräs Juha; Hakumäki Juhana M; Hyttinen Mika M; Helminen Heikki J; Jurvelin Jukka S
Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;48(4):640-8.
2002: Lapveteläinen T; Hyttinen M M; Säämänen A-M; Långsjö T; Sahlman J; Felszeghy S; Vuorio E; Helminen H J
Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice.
Annals of the rheumatic diseases 2002;61(9):810-7.
2002: Sironen Reijo K; Karjalainen Hannu M; Elo Mika A; Kaarniranta Kai; Törrönen Kari; Takigawa Masaharu; Helminen Heikki J; Lammi Mikko J
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure.
Biochimica et biophysica acta 2002;1591(1-3):45-54.
2002: Helminen H J; Säämänen A-M; Salminen H; Hyttinen M M
Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis.
Rheumatology (Oxford, England) 2002;41(8):848-56.
2002: Korhonen R K; Laasanen M S; Töyräs J; Rieppo J; Hirvonen J; Helminen H J; Jurvelin J S
Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation.
Journal of biomechanics 2002;35(7):903-9.
2002: Kaarniranta K; Oksala N; Karjalainen H M; Suuronen T; Sistonen L; Helminen H J; Salminen A; Lammi M J
Neuronal cells show regulatory differences in the hsp70 gene response.
Brain research. Molecular brain research 2002;101(1-2):136-40.
2002: Korhonen R K; Wong M; Arokoski J; Lindgren R; Helminen H J; Hunziker E B; Jurvelin J S
Importance of the superficial tissue layer for the indentation stiffness of articular cartilage.
Medical engineering & physics 2002;24(2):99-108.
2002: Arokoski J P A; Arokoski M H; Jurvelin J S; Helminen H J; Niemitukia L H; Kröger H
Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis.
Annals of the rheumatic diseases 2002;61(2):145-50.
2002: Långsjö Teemu K; Rieppo Jarno; Pelttari Alpo; Oksala Niku; Kovanen Vuokko; Helminen Heikki J
Collagenase-induced changes in articular cartilage as detected by electron-microscopic stereology, quantitative polarized light microscopy and biochemical assays.
Cells, tissues, organs 2002;172(4):265-75.
2002: Töyräs J; Nieminen H J; Laasanen M S; Nieminen M T; Korhonen R K; Rieppo J; Hirvonen J; Helminen H J; Jurvelin J S
Ultrasonic characterization of articular cartilage.
Biorheology 2002;39(1-2):161-9.
2002: Sironen Reijo K; Karjalainen Hannu M; Törrönen Kari; Elo Mika A; Kaarniranta Kai; Takigawa Masaharu; Helminen Heikki J; Lammi Mikko J
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis.
Biorheology 2002;39(1-2):111-7.
2001: Sahlman J; Inkinen R; Hirvonen T; Lammi M J; Lammi P E; Nieminen J; Lapveteläinen T; Prockop D J; Arita M; Li S W; Hyttinen M M; Helminen H J; Puustjärvi K
Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen.
Spine 2001;26(23):2558-65.
2001: Hyttinen M M; Arokoski J P; Parkkinen J J; Lammi M J; Lapveteläinen T; Mauranen K; Király K; Tammi M I; Helminen H J
Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(8):694-701.
2001: Espanha M M; Lammi P E; Hyttinen M M; Lammi M J; Helminen H J
Extracellular matrix composition of full-thickness defect repair tissue is little influenced by exercise in rat articular cartilage.
Connective tissue research 2001;42(2):97-109.
2001: Suominen M M; Tulamo R M; Anttila M O; Sankari S M; Király K; Lapveteläinen T; Helminen H J
Effects of intra-articular injections of bufexamac suspension in healthy horses.
American journal of veterinary research 2001;62(10):1629-35.
2001: Nieminen M T; Rieppo J; Töyräs J; Hakumäki J M; Silvennoinen J; Hyttinen M M; Helminen H J; Jurvelin J S
T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):487-93.
2001: Hyttinen M M; Töyräs J; Lapveteläinen T; Lindblom J; Prockop D J; Li S W; Arita M; Jurvelin J S; Helminen H J
Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer.
Annals of the rheumatic diseases 2001;60(3):262-8.
2001: Lapveteläinen T; Hyttinen M; Lindblom J; Långsjö T K; Sironen R; Li S W; Arita M; Prockop D J; Puustjärvi K; Helminen H J
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):152-60.
2001: Kaarniranta K; Holmberg C I; Lammi M J; Eriksson J E; Sistonen L; Helminen H J
Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):7-13.
2001: Haapala J; Arokoski J P; Rönkkö S; Agren U; Kosma V M; Lohmander L S; Tammi M; Helminen H J; Kiviranta I
Decline after immobilisation and recovery after remobilisation of synovial fluid IL1, TIMP, and chondroitin sulphate levels in young beagle dogs.
Annals of the rheumatic diseases 2001;60(1):55-60.
2001: Kaarniranta K; Oksala N; Lammi M J; Helminen H J; Sistonen L
[From research of cellular stress to various clinical break through innovations?]
Duodecim; lääketieteellinen aikakauskirja 2001;117(22):2266-72.
2001: Arokoski J P; Lammi M J; Hyttinen M M; Kiviranta I; Parkkinen J J; Jurvelin J S; Tammi M I; Helminen H J
[Etiopathogenesis of osteoarthritis]
Duodecim; lääketieteellinen aikakauskirja 2001;117(16):1617-26; quiz 1626, 1679.
2000: Elo M A; Sironen R K; Kaarniranta K; Auriola S; Helminen H J; Lammi M J
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytic cells.
Journal of cellular biochemistry 2000;79(4):610-9.
2000: Arokoski J P; Jurvelin J S; Väätäinen U; Helminen H J
Normal and pathological adaptations of articular cartilage to joint loading.
Scandinavian journal of medicine & science in sports 2000;10(4):186-98.
2000: Kaarniranta K; Holmberg C I; Helminen H J; Eriksson J E; Sistonen L; Lammi M J
Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature.
FEBS letters 2000;475(3):283-6.
2000: Jurvelin J S; Arokoski J P; Hunziker E B; Helminen H J
Topographical variation of the elastic properties of articular cartilage in the canine knee.
Journal of biomechanics 2000;33(6):669-75.
2000: Nieminen M T; Töyräs J; Rieppo J; Hakumäki J M; Silvennoinen J; Helminen H J; Jurvelin J S
Quantitative MR microscopy of enzymatically degraded articular cartilage.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;43(5):676-81.
2000: Haapala J; Arokoski J; Pirttimäki J; Lyyra T; Jurvelin J; Tammi M; Helminen H J; Kiviranta I
Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization.
International journal of sports medicine 2000;21(1):76-81.
2000: Helminen H J; Hyttinen M M; Lammi M J; Arokoski J P; Lapveteläinen T; Jurvelin J; Kiviranta I; Tammi M I
Regular joint loading in youth assists in the establishment and strengthening of the collagen network of articular cartilage and contributes to the prevention of osteoarthrosis later in life: a hypothesis.
Journal of bone and mineral metabolism 2000;18(5):245-57.
2000: Sironen R; Elo M; Kaarniranta K; Helminen H J; Lammi M J
Transcriptional activation in chondrocytes submitted to hydrostatic pressure.
Biorheology 2000;37(1-2):85-93.
1999: Töyräs J; Rieppo J; Nieminen M T; Helminen H J; Jurvelin J S
Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound.
Physics in medicine and biology 1999;44(11):2723-33.
1999: Långsjö T K; Hyttinen M; Pelttari A; Kiraly K; Arokoski J; Helminen H J
Electron microscopic stereological study of collagen fibrils in bovine articular cartilage: volume and surface densities are best obtained indirectly (from length densities and diameters) using isotropic uniform random sampling.
Journal of anatomy 1999;195 ( Pt 2)():281-93.
1999: Harri M; Lindblom J; Malinen H; Hyttinen M; Lapveteläinen T; Eskola S; Helminen H J
Effect of access to a running wheel on behavior of C57BL/6J mice.
Laboratory animal science 1999;49(4):401-5.
1999: Haapala J; Arokoski J P; Hyttinen M M; Lammi M; Tammi M; Kovanen V; Helminen H J; Kiviranta I
Remobilization does not fully restore immobilization induced articular cartilage atrophy.
Clinical orthopaedics and related research 1999;(362):218-29.
1999: Puustjärvi K; Nieminen J; Räsänen T; Hyttinen M; Helminen H J; Kröger H; Huuskonen J; Alhava E; Kovanen V
Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training?
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(3):321-9.
1999: Lyyra T; Kiviranta I; Väätäinen U; Helminen H J; Jurvelin J S
In vivo characterization of indentation stiffness of articular cartilage in the normal human knee.
Journal of biomedical materials research 1999;48(4):482-7.
1999: Arokoski J P; Hyttinen M M; Helminen H J; Jurvelin J S
Biomechanical and structural characteristics of canine femoral and tibial cartilage.
Journal of biomedical materials research 1999;48(2):99-107.
1998: Király K; Hyttinen M M; Parkkinen J J; Arokoski J A; Lapveteläinen T; Törrönen K; Kiviranta I; Helminen H J
Articular cartilage collagen birefringence is altered concurrent with changes in proteoglycan synthesis during dynamic in vitro loading.
The Anatomical record 1998;251(1):28-36.
1998: Panula H E; Hyttinen M M; Arokoski J P; Långsjö T K; Pelttari A; Kiviranta I; Helminen H J
Articular cartilage superficial zone collagen birefringence reduced and cartilage thickness increased before surface fibrillation in experimental osteoarthritis.
Annals of the rheumatic diseases 1998;57(4):237-45.
1998: Panula H E; Lohmander L S; Rönkkö S; Agren U; Helminen H J; Kiviranta I
Elevated levels of synovial fluid PLA2, stromelysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs.
Acta orthopaedica Scandinavica 1998;69(2):152-8.
1998: Kaarniranta K; Elo M; Sironen R; Lammi M J; Goldring M B; Eriksson J E; Sistonen L; Helminen H J
Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2319-24.
1997: Panula H E; Helminen H J; Kiviranta I
Slowly progressive osteoarthritis after tibial valgus osteotomy in young beagle dogs.
Clinical orthopaedics and related research 1997;(343):192-202.
1997: Király K; Hyttinen M M; Lapveteläinen T; Elo M; Kiviranta I; Dobai J; Módis L; Helminen H J; Arokoski J P
Specimen preparation and quantification of collagen birefringence in unstained sections of articular cartilage using image analysis and polarizing light microscopy.
The Histochemical journal 1997;29(4):317-27.
1997: Jortikka M O; Inkinen R I; Tammi M I; Parkkinen J J; Haapala J; Kiviranta I; Helminen H J; Lammi M J
Immobilisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage.
Annals of the rheumatic diseases 1997;56(4):255-61.
1997: Lapveteläinen T; Tiihonen A; Koskela P; Nevalainen T; Lindblom J; Király K; Halonen P; Helminen H J
Training a large number of laboratory mice using running wheels and analyzing running behavior by use of a computer-assisted system.
Laboratory animal science 1997;47(2):172-9.
1996: Haapala J; Lammi M J; Inkinen R; Parkkinen J J; Agren U M; Arokoski J; Kiviranta I; Helminen H J; Tammi M I
Coordinated regulation of hyaluronan and aggrecan content in the articular cartilage of immobilized and exercised dogs.
The Journal of rheumatology 1996;23(9):1586-93.
1996: Király K; Lapveteläinen T; Arokoski J; Törrönen K; Módis L; Kiviranta I; Helminen H J
Application of selected cationic dyes for the semiquantitative estimation of glycosaminoglycans in histological sections of articular cartilage by microspectrophotometry.
The Histochemical journal 1996;28(8):577-90.
1996: Arokoski J P; Hyttinen M M; Lapveteläinen T; Takács P; Kosztáczky B; Módis L; Kovanen V; Helminen H
Decreased birefringence of the superficial zone collagen network in the canine knee (stifle) articular cartilage after long distance running training, detected by quantitative polarised light microscopy.
Annals of the rheumatic diseases 1996;55(4):253-64.
1996: Parkkinen J J; Häkkinen T P; Savolainen S; Wang C; Tammi R; Agren U M; Lammi M J; Arokoski J; Helminen H J; Tammi M I
Distribution of hyaluronan in articular cartilage as probed by a biotinylated binding region of aggrecan.
Histochemistry and cell biology 1996;105(3):187-94.
1996: Király K; Lammi M; Arokoski J; Lapveteläinen T; Tammi M; Helminen H; Kiviranta I
Safranin O reduces loss of glycosaminoglycans from bovine articular cartilage during histological specimen preparation.
The Histochemical journal 1996;28(2):99-107.
1996: Módis L; Botos A; Kiviranta I; Lukácskó L; Helminen H J
Differences in submicroscopic structure of the extracellular matrix of canine femoral and tibial condylar articular cartilages as revealed by polarization microscopical analysis.
Acta biologica Hungarica 1996;47(1-4):341-53.
1995: Li S W; Prockop D J; Helminen H; Fässler R; Lapveteläinen T; Kiraly K; Peltarri A; Arokoski J; Lui H; Arita M
Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone.
Genes & development 1995;9(22):2821-30.
1995: Parkkinen J J; Lammi M J; Inkinen R; Jortikka M; Tammi M; Virtanen I; Helminen H J
Influence of short-term hydrostatic pressure on organization of stress fibers in cultured chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(4):495-502.
1995: Lapveteläinen T; Nevalainen T; Parkkinen J J; Arokoski J; Kiraly K; Hyttinen M; Halonen P; Helminen H J
Lifelong moderate running training increases the incidence and severity of osteoarthritis in the knee joint of C57BL mice.
The Anatomical record 1995;242(2):159-65.
1995: Puustjärvi K; Lappalainen R; Niemitukia L; Arnala I; Nieminen J; Tammi M; Helminen H J
Long-distance running alters bone anthropometry, elemental composition and mineral density of young dogs.
Scandinavian journal of medicine & science in sports 1995;5(1):17-23.
1994: Arokoski J; Jurvelin J; Kiviranta I; Tammi M; Helminen H J
Softening of the lateral condyle articular cartilage in the canine knee joint after long distance (up to 40 km/day) running training lasting one year.
International journal of sports medicine 1994;15(5):254-60.
1994: Kiviranta I; Tammi M; Jurvelin J; Arokoski J; Säämänen A M; Helminen H J
Articular cartilage thickness and glycosaminoglycan distribution in the young canine knee joint after remobilization of the immobilized limb.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):161-7.
1994: Mäntymaa P; Arokoski J; Pörsti I; Perhonen M; Arvola P; Helminen H J; Takala T E; Leppäluoto J; Ruskoaho H
Effect of endurance training on atrial natriuretic peptide gene expression in normal and hypertrophied hearts.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(3):1184-94.
1994: Puustjärvi K; Lammi M; Helminen H; Inkinen R; Tammi M
Proteoglycans in the intervertebral disc of young dogs following strenuous running exercise.
Connective tissue research 1994;30(3):225-40.
1994: Puustjärvi K; Tammi M; Reinikainen M; Helminen H J; Paljärvi L
Running training alters fiber type composition in spinal muscles.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 1994;3(1):17-21.
1993: Prockop D J; Colige A; Helminen H; Khillan J S; Pereira R; Vandenberg P
Mutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8 Suppl 2():S489-92.
1993: Arokoski J; Kiviranta I; Jurvelin J; Tammi M; Helminen H J
Long-distance running causes site-dependent decrease of cartilage glycosaminoglycan content in the knee joints of beagle dogs.
Arthritis and rheumatism 1993;36(10):1451-9.
1993: Puustjärvi K; Lammi M; Kiviranta I; Helminen H J; Tammi M
Proteoglycan synthesis in canine intervertebral discs after long-distance running training.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1993;11(5):738-46.
1993: Helminen H J; Kiraly K; Pelttari A; Tammi M I; Vandenberg P; Pereira R; Dhulipala R; Khillan J S; Ala-Kokko L; Hume E L
An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.
The Journal of clinical investigation 1993;92(2):582-95.
1993: Lammi M J; Häkkinen T P; Parkkinen J J; Hyttinen M M; Jortikka M; Helminen H J; Tammi M I
Adaptation of canine femoral head articular cartilage to long distance running exercise in young beagles.
Annals of the rheumatic diseases 1993;52(5):369-77.
1993: Parkkinen J J; Lammi M J; Pelttari A; Helminen H J; Tammi M; Virtanen I
Altered Golgi apparatus in hydrostatically loaded articular cartilage chondrocytes.
Annals of the rheumatic diseases 1993;52(3):192-8.
1993: Pereira R; Khillan J S; Helminen H J; Hume E L; Prockop D J
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.
The Journal of clinical investigation 1993;91(2):709-16.
1993: Puustjärvi K; Lammi M J; Kiviranta I; Helminen H J; Tammi M
Flat bed scanner in the quantitative assay of 35SO4-incorporation by X-ray film autoradiography of intervertebral disc sections.
Histochemistry 1993;99(1):67-73.
1993: Säämänen A M; Puustjärvi K; Ilves K; Lammi M; Kiviranta I; Jurvelin J; Helminen H J; Tammi M
Effect of running exercise on proteoglycans and collagen content in the intervertebral disc of young dogs.
International journal of sports medicine 1993;14(1):48-51.
1993: Parkkinen J J; Ikonen J; Lammi M J; Laakkonen J; Tammi M; Helminen H J
Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants.
Archives of biochemistry and biophysics 1993;300(1):458-65.
1993: Lammi M J; Häkkinen T P; Parkkinen J J; Hyttinen M; Jortikka M; Helminen H J; Tammi M
Effects of long-term running exercise on canine femoral head articular cartilage.
Agents and actions. Supplements 1993;39():95-9.
1993: Arokoski J; Miettinen P V; Säämänen A M; Haapanen K; Parviainen M; Tammi M; Helminen H J
Effects of aerobic long distance running training (up to 40 km.day-1) of 1-year duration on blood and endocrine parameters of female beagle dogs.
European journal of applied physiology and occupational physiology 1993;67(4):321-9.
1992: Oettmeier R; Arokoski J; Roth A J; Helminen H J; Tammi M; Abendroth K
Quantitative study of articular cartilage and subchondral bone remodeling in the knee joint of dogs after strenuous running training.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7 Suppl 2():S419-24.
1992: Kiviranta I; Tammi M; Jurvelin J; Arokoski J; Säämänen A M; Helminen H J
Articular cartilage thickness and glycosaminoglycan distribution in the canine knee joint after strenuous running exercise.
Clinical orthopaedics and related research 1992;(283):302-8.
1992: Parkkinen J J; Lammi M J; Helminen H J; Tammi M
Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1992;10(5):610-20.
1992: Puustjärvi K; Karjalainen P; Nieminen J; Arokoski J; Parviainen M; Helminen H J; Soimakallio S
Endurance training associated with slightly lowered serum estradiol levels decreases mineral density of canine skeleton.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(6):619-24.
1992: Helminen H J; Säämänen A M; Jurvelin J; Kiviranta I; Parkkinen J J; Lammi M J; Tammi M
[The effect of loading on articular cartilage]
Duodecim; lääketieteellinen aikakauskirja 1992;108(12):1097-107.
1991: Vandenberg P; Khillan J S; Prockop D J; Helminen H; Kontusaari S; Ala-Kokko L
Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7640-4.
1991: Arokoski J; Kiviranta I; Laakkonen J; Tiihonen A; Sopanen E; Ikonen J; Nevalainen T; Haapanen K; Tammi M; Helminen H J
A ten-track treadmill for running training of dogs.
Laboratory animal science 1991;41(3):246-50.
1991: Puustjärvi K; Karjalainen P; Nieminen J; Helminen H J; Soimakallio S; Kivimäki T; Arokoski J
Effects of long-term running on spinal mineral content in dogs.
Calcified tissue international 1991;49 Suppl():S81-2.
1990: Säämänen A M; Tammi M; Jurvelin J; Kiviranta I; Helminen H J
Proteoglycan alterations following immobilization and remobilization in the articular cartilage of young canine knee (stifle) joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1990;8(6):863-73.
1990: Parkkinen J J; Paukkonen K; Pesonen E; Lammi M J; Markkanen S; Helminen H J; Tammi M
Quantitation of autoradiographic grains in different zones of articular cartilage with image analyzer.
Histochemistry 1990;93(3):241-5.
1990: Jurvelin J; Kiviranta I; Säämänen A M; Tammi M; Helminen H J
Indentation stiffness of young canine knee articular cartilage--influence of strenuous joint loading.
Journal of biomechanics 1990;23(12):1239-46.
1989: Säämänen A M; Tammi M; Kiviranta I; Jurvelin J; Helminen H J
Levels of chondroitin-6-sulfate and nonaggregating proteoglycans at articular cartilage contact sites in the knees of young dogs subjected to moderate running exercise.
Arthritis and rheumatism 1989;32(10):1282-92.
1989: Jurvelin J; Kiviranta I; Säämänen A M; Tammi M; Helminen H J
Partial restoration of immobilization-induced softening of canine articular cartilage after remobilization of the knee (stifle) joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(3):352-8.
1989: Parkkinen J J; Lammi M J; Karjalainen S; Laakkonen J; Hyvärinen E; Tiihonen A; Helminen H J; Tammi M
A mechanical apparatus with microprocessor controlled stress profile for cyclic compression of cultured articular cartilage explants.
Journal of biomechanics 1989;22(11-12):1285-91.
1988: Säämänen A M; Tammi M; Kiviranta I; Helminen H J
Running exercise as a modulatory of proteoglycan matrix in the articular cartilage of young rabbits.
International journal of sports medicine 1988;9(2):127-33.
1988: Jurvelin J; Lahtinen T; Kiviranta I; Arnala I; Lappalainen R; Tammi M; Helminen H J
Blood flow, histomorphology and elemental composition of the canine femur after physical training or immobilization.
Acta physiologica Scandinavica 1988;132(3):385-9.
1988: Kiviranta I; Tammi M; Jurvelin J; Säämänen A M; Helminen H J
Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(2):188-95.
1988: Tammi M; Kiviranta I; Peltonen L; Jurvelin J; Helminen H J
Effects of joint loading on articular cartilage collagen metabolism: assay of procollagen prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase.
Connective tissue research 1988;17(3):199-206.
1987: Paukkonen K; Helminen H J
Chondrocyte ultrastructure in exercise and experimental osteoarthrosis. A stereologic morphometric study of articular cartilage of young rabbits using transmission electron microscopy.
Clinical orthopaedics and related research 1987;(224):284-8.
1987: Paukkonen K; Helminen H J
Decrease of proteoglycan granule number but increase of their size in articular cartilage of young rabbits after physical exercise and immobilization by splinting.
The Anatomical record 1987;219(1):45-52.
1987: Kiviranta I; Jurvelin J; Tammi M; Säämänen A M; Helminen H J
Weight bearing controls glycosaminoglycan concentration and articular cartilage thickness in the knee joints of young beagle dogs.
Arthritis and rheumatism 1987;30(7):801-9.
1987: Paukkonen K; Helminen H J
Rough endoplasmic reticulum and fine intracytoplasmic filaments in articular cartilage chondrocytes of young rabbits; a stereological morphometric study using transmission electron microscopy.
Journal of anatomy 1987;152():47-54.
1987: Kiviranta I; Tammi M; Jurvelin J; Helminen H J
Topographical variation of glycosaminoglycan content and cartilage thickness in canine knee (stifle) joint cartilage. Application of the microspectrophotometric method.
Journal of anatomy 1987;150():265-76.
1987: Säämänen A M; Tammi M; Kiviranta I; Jurvelin J; Helminen H J
Maturation of proteoglycan matrix in articular cartilage under increased and decreased joint loading. A study in young rabbits.
Connective tissue research 1987;16(2):163-75.
1986: Paukkonen K; Jurvelin J; Helminen H J
Effects of immobilization on the articular cartilage in young rabbits. A quantitative light microscopic stereological study.
Clinical orthopaedics and related research 1986;(206):270-80.
1985: Helminen H J; Jurvelin J; Tammi M; Pelttari A; Svartbäck C M; Kiviranta I; Säämänen A M; Paukkonen K
Prolonged ethanol replacement by CO2 increases splits on articular cartilage surface after critical point drying.
Journal of microscopy 1985;137(Pt 3):305-12.
1985: Jurvelin J; Helminen H J; Lauritsalo S; Kiviranta I; Säämänen A M; Paukkonen K; Tammi M
Influences of joint immobilization and running exercise on articular cartilage surfaces of young rabbits. A semiquantitative stereomicroscopic and scanning electron microscopic study.
Acta anatomica 1985;122(1):62-8.
1985: Kiviranta I; Tammi M; Jurvelin J; Säämänen A M; Helminen H J
Demonstration of chondroitin sulphate and glycoproteins in articular cartilage matrix using periodic acid-Schiff (PAS) method.
Histochemistry 1985;83(4):303-6.
1985: Kiviranta I; Jurvelin J; Tammi M; Säämänen A M; Helminen H J
Microspectrophotometric quantitation of glycosaminoglycans in articular cartilage sections stained with Safranin O.
Histochemistry 1985;82(3):249-55.
1984: Paukkonen K; Selkäinaho K; Jurvelin J; Helminen H J
Morphometry of articular cartilage: a stereological method using light microscopy.
The Anatomical record 1984;210(4):675-82.
1984: Kiviranta I; Tammi M; Jurvelin J; Säämänen A M; Helminen H J
Fixation, decalcification, and tissue processing effects on articular cartilage proteoglycans.
Histochemistry 1984;80(6):569-73.
1984: Paukkonen K; Helminen H J; Tammi M; Jurvelin J; Kiviranta I; Säämänen A M
Quantitative morphological and biochemical investigations on the effects of physical exercise and immobilization on the articular cartilage of young rabbits.
Acta biologica Hungarica 1984;35(2-4):293-304.
1983: Helminen H J; Jurvelin J; Kuusela T; Heikkilä R; Kiviranta I; Tammi M
Effects of immobilization for 6 weeks on rabbit knee articular surfaces as assessed by the semiquantitative stereomicroscopic method.
Acta anatomica 1983;115(4):327-35.
1983: Helminen H J; Jurvelin J; Kuusela T; Heikkilä R; Kiviranta I; Tammi M
Semiquantitative analysis of rabbit knee articular surfaces based on stereomicroscopic examination of the cartilage.
Acta anatomica 1983;115(4):319-26.
1983: Jurvelin J; Kuusela T; Heikkilä R; Pelttari A; Kiviranta I; Tammi M; Helminen H J
Investigation of articular cartilage surface morphology with a semiquantitative scanning electron microscopic method.
Acta anatomica 1983;116(4):302-11.
1983: Tammi M; Säämänen A M; Jauhiainen A; Malminen O; Kiviranta I; Helminen H
Proteoglycan alterations in rabbit knee articular cartilage following physical exercise and immobilization.
Connective tissue research 1983;11(1):45-55.
1980: Kiviranta I; Tammi M; Lappalainen R; Kuusela T; Helminen H J
The rate of calcium extraction during EDTA decalcification from thin bone slices as assessed with atomic absorption spectrophotometry.
Histochemistry 1980;68(2):119-27.

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