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Brian Hemmings

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Brian A Hemmings; David Restuccia; Nick Tonks
Targeting the Kinome II.
Lisa Héron-Milhavet; Celine Franckhauser; Vanessa Rana; Cyril Berthenet; Daniel Fisher; Brian A Hemmings; Anne Fernandez; Ned J C Lamb
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Ivana Galetic; Sauveur-Michel Maira; Mirjana Andjelkovic; Brian A Hemmings
Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription.

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All Publications

2009: Brian A Hemmings; David Restuccia; Nick Tonks
Targeting the Kinome II.
Current opinion in cell biology 2009;21(2):135-9.
2006: Lisa Héron-Milhavet; Celine Franckhauser; Vanessa Rana; Cyril Berthenet; Daniel Fisher; Brian A Hemmings; Anne Fernandez; Ned J C Lamb
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Molecular and cellular biology 2006;26(22):8267-80.
2003: Ivana Galetic; Sauveur-Michel Maira; Mirjana Andjelkovic; Brian A Hemmings
Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription.
The Journal of biological chemistry 2003;278(7):4416-23.
2001: Sauveur-Michel Maira; Ivana Galetic; Derek Brazil; Stefanie Kaech; Evan Ingley; M Thelen; Brian A Hemmings
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
Science (New York, N.Y.) 2001;294(5541):374-80.
2001: D Brodbeck; M M Hill; Brian A Hemmings
Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain.
The Journal of biological chemistry 2001;276(31):29550-8.
2001: Marie Vandromme; Anne Rochat; R Meier; Gilles Carnac; Daniel Besser; Brian A Hemmings; Anne Fernandez; Ned J C Lamb
Protein kinase B beta/Akt2 plays a specific role in muscle differentiation.
The Journal of biological chemistry 2001;276(11):8173-9.
2000: L M Bell; Meredith L L Leong; B Kim; E Wang; Jongsun Park; Brian A Hemmings; Gary L Firestone
Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway.
The Journal of biological chemistry 2000;275(33):25262-72.
1999: TA Millward; daniel Hess; Brian A Hemmings
Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs.
The Journal of biological chemistry 1999;274(48):33847-50.
1999: M Andjelković; Sauveur-Michel Maira; P Cron; P J Parker; Brian A Hemmings
Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase.
Molecular and cellular biology 1999;19(7):5061-72.
1999: Patric Turowski; Timothy Myles; Brian A Hemmings; Anne Fernandez; Ned J C Lamb
Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.
Molecular biology of the cell 1999;10(6):1997-2015.
1999: Jongsun Park; Meredith L L Leong; Patricia Buse; Anita C Maiyar; G L Firestone; Brian A Hemmings
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.
The EMBO journal 1999;18(11):3024-33.
1999: Ivana Galetic; Mirjana Andjelkovic; R Meier; D Brodbeck; Jongsun Park; Brian A Hemmings
Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer.
Pharmacology & therapeutics 1999;82(2-3):409-25.
1999: TA Millward; S Zolnierowicz; Brian A Hemmings
Regulation of protein kinase cascades by protein phosphatase 2A.
Trends in biochemical sciences 1999;24(5):186-91.
1999: D Brodbeck; P Cron; Brian A Hemmings
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.
The Journal of biological chemistry 1999;274(14):9133-6.
1999: R Meier; Brian A Hemmings
Regulation of protein kinase B.
Journal of receptor and signal transduction research 1999;19(1-4):121-8.
1998: TA Millward; C W Heizmann; B W Schäfer; Brian A Hemmings
Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins.
The EMBO journal 1998;17(20):5913-22.
1998: ruedi meili; P Cron; Brian A Hemmings; K Ballmer-Hofer
Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism.
Oncogene 1998;16(7):903-7.
1998: M Andjelković; Hana S Suidan; R Meier; M Frech; DR Alessi; Brian A Hemmings
Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells.
European journal of biochemistry / FEBS 1998;251(1-2):195-200.
1998: M Frech; Brian A Hemmings
PH domain of serine-threonine protein kinase B (RAC-PKB). Expression and binding assay for phosphoinositides and inositol phosphates.
Methods in molecular biology (Clifton, N.J.) 1998;88():197-210.
1997: M Andjelković; DR Alessi; R Meier; A Fernandez; N J Lamb; M Frech; P Cron; P Cohen; J M Lucocq; Brian A Hemmings
Role of translocation in the activation and function of protein kinase B.
The Journal of biological chemistry 1997;272(50):31515-24.
1997: R Meier; DR Alessi; P Cron; M Andjelković; Brian A Hemmings
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
The Journal of biological chemistry 1997;272(48):30491-7.
1997: Patric Turowski; B Favre; K S Campbell; N J Lamb; Brian A Hemmings
Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65alpha.
European journal of biochemistry / FEBS 1997;248(1):200-8.
1997: B Favre; Patric Turowski; Brian A Hemmings
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin.
The Journal of biological chemistry 1997;272(21):13856-63.
1997: Brian A Hemmings
PH domains--a universal membrane adapter.
Science (New York, N.Y.) 1997;275(5308):1899.
1997: M Frech; Mirjana Andjelkovic; Evan Ingley; K K Reddy; J R Falck; Brian A Hemmings
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity.
The Journal of biological chemistry 1997;272(13):8474-81.
1997: Brian A Hemmings
Akt signaling: linking membrane events to life and death decisions.
Science (New York, N.Y.) 1997;275(5300):628-30.
1996: N Andjelković; S Zolnierowicz; Christine Van Hoof; Jozef Goris; Brian A Hemmings
The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.
The EMBO journal 1996;15(24):7156-67.
1996: Dario R Alessi; F B Caudwell; Mirjana Andjelkovic; Brian A Hemmings; Philip Cohen
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.
FEBS letters 1996;399(3):333-8.
1996: Dario R Alessi; Mirjana Andjelkovic; B Caudwell; P Cron; Nick Morrice; Philip Cohen; Brian A Hemmings
Mechanism of activation of protein kinase B by insulin and IGF-1.
The EMBO journal 1996;15(23):6541-51.
1996: S Zolnierowicz; Christine Van Hoof; N Andjelković; P Cron; Ilse Stevens; Wilfried Merlevede; Jozef Goris; Brian A Hemmings
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.
The Biochemical journal 1996;317 ( Pt 1)():187-94.
1996: M Andjelković; T Jakubowicz; P Cron; X F Ming; J W Han; Brian A Hemmings
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5699-704.
1995: Darren A E Cross; Dario R Alessi; Philip Cohen; M Andjelkovich; Brian A Hemmings
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Nature 1995;378(6559):785-9.
1995: S Wera; Brian A Hemmings
Serine/threonine protein phosphatases.
The Biochemical journal 1995;311 ( Pt 1)():17-29.
1995: S Wera; A Fernandez; N J Lamb; Patric Turowski; M Hemmings-Mieszczak; R E Mayer-Jaekel; Brian A Hemmings
Deregulation of translational control of the 65-kDa regulatory subunit (PR65 alpha) of protein phosphatase 2A leads to multinucleated cells.
The Journal of biological chemistry 1995;270(36):21374-81.
1995: M Frech; Evan Ingley; Mirjana Andjelkovic; Brian A Hemmings
Pleckstrin homology domains.
Biochemical Society transactions 1995;23(3):616-8.
1995: R E Mayer-Jaekel; Brian A Hemmings
Role of protein phosphatase 2A in Drosophila development.
Seminars in cancer biology 1995;6(4):249-56.
1995: M Bosch; Xavier Cayla; Christine Van Hoof; Brian A Hemmings; René Ozon; Wilfried Merlevede; Jozef Goris
The PR55 and PR65 subunits of protein phosphatase 2A from Xenopus laevis. molecular cloning and developmental regulation of expression.
European journal of biochemistry / FEBS 1995;230(3):1037-45.
1995: T Millward; P Cron; Brian A Hemmings
Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5022-6.
1995: Patric Turowski; A Fernandez; B Favre; N J Lamb; Brian A Hemmings
Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression.
The Journal of cell biology 1995;129(2):397-410.
1995: M Andjelković; Pam Jones; Ueli Grossniklaus; P Cron; A F Schier; M Dick; G Bilbe; Brian A Hemmings
Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase.
The Journal of biological chemistry 1995;270(8):4066-75.
1994: Evan Ingley; Brian A Hemmings
Pleckstrin homology (PH) domains in signal transduction.
Journal of cellular biochemistry 1994;56(4):436-43.
1994: R E Mayer-Jaekel; H Ohkura; P Ferrigno; N Andjelkovic; K Shiomi; T Uemura; David M Glover; Brian A Hemmings
Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.
Journal of cell science 1994;107 ( Pt 9)():2609-16.
1994: S Zolnierowicz; P Cron; S Solinas-Toldo; R Fries; H Y Lin; Brian A Hemmings
Isolation, characterization, and chromosomal localization of the porcine calcitonin receptor gene. Identification of two variants of the receptor generated by alternative splicing.
The Journal of biological chemistry 1994;269(30):19530-8.
1994: B Favre; S Zolnierowicz; Patric Turowski; Brian A Hemmings
The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.
The Journal of biological chemistry 1994;269(23):16311-7.
1994: AM Vicentini; Brian A Hemmings; Jan Hofsteenge
Residues 36-42 of liver RNase PL3 contribute to its uridine-preferring substrate specificity. Cloning of the cDNA and site-directed mutagenesis studies.
Protein science : a publication of the Protein Society 1994;3(3):459-66.
1994: J S Lee; L Catanzariti; Brian A Hemmings; B Kiefer; Yoshikuni Nagamine
Activation of cAMP-dependent protein kinase alters the chromatin structure of the urokinase-type plasminogen activator gene promoter.
Nucleic acids research 1994;22(4):569-75.
1994: J S Lee; B Favre; Brian A Hemmings; B Kiefer; Y Nagamine
Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun.
The Journal of biological chemistry 1994;269(4):2887-94.
1993: P Hendrix; R E Mayer-Jackel; P Cron; Jozef Goris; Jan Hofsteenge; Wilfried Merlevede; Brian A Hemmings
Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.
The Journal of biological chemistry 1993;268(20):15267-76.
1993: P Hendrix; Patric Turowski; R E Mayer-Jaekel; Jozef Goris; Jan Hofsteenge; Wilfried Merlevede; Brian A Hemmings
Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus.
The Journal of biological chemistry 1993;268(10):7330-7.
1993: R E Mayer-Jaekel; H Ohkura; R Gomes; Claudio Sunkel; Stefan Baumgartner; Brian A Hemmings; David M Glover
The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase.
Cell 1993;72(4):621-33.
1992: R E Mayer-Jaekel; Stefan Baumgartner; G Bilbe; H Ohkura; David M Glover; Brian A Hemmings
Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila.
Molecular biology of the cell 1992;3(3):287-98.
1992: Hana S Suidan; SR Stone; Brian A Hemmings; Denis Monard
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.
Neuron 1992;8(2):363-75.
1991: P F Jones; T Jakubowicz; Brian A Hemmings
Molecular cloning of a second form of rac protein kinase.
Cell regulation 1991;2(12):1001-9.
1991: P F Jones; T Jakubowicz; F J Pitossi; F Maurer; Brian A Hemmings
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4171-5.
1991: R E Mayer; P Hendrix; P Cron; R Matthies; SR Stone; Jozef Goris; Wilfried Merlevede; Jan Hofsteenge; Brian A Hemmings
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.
Biochemistry 1991;30(15):3589-97.
1991: D Rennex; Brian A Hemmings; Jan Hofsteenge; SR Stone
cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue.
Biochemistry 1991;30(8):2195-203.
1991: Y Khew-Goodall; R E Mayer; F Maurer; SR Stone; Brian A Hemmings
Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.
Biochemistry 1991;30(1):89-97.
1991: D Pearson; E A Nigg; Yoshikuni Nagamine; D A Jans; Brian A Hemmings
Mechanisms of cAMP-mediated gene induction: examination of renal epithelial cell mutants affected in the catalytic subunit of the cAMP-dependent protein kinase.
Experimental cell research 1991;192(1):315-8.
1990: AM Vicentini; B Kieffer; R Matthies; B Meyhack; Brian A Hemmings; SR Stone; Jan Hofsteenge
Protein chemical and kinetic characterization of recombinant porcine ribonuclease inhibitor expressed in Saccharomyces cerevisiae.
Biochemistry 1990;29(37):8827-34.
1990: Brian A Hemmings; C Adams-Pearson; F Maurer; P Müller; J Goris; W Merlevede; Jan Hofsteenge; S R Stone
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.
Biochemistry 1990;29(13):3166-73.
1990: R E Mayer; Y Khew-Goodall; SR Stone; Brian A Hemmings
Expression and organization of protein phosphatase 2A catalytic subunit genes.
Advances in second messenger and phosphoprotein research 1990;24():236-41.
1988: Brian A Hemmings; W Wernet; R Mayer; F Maurer; Jan Hofsteenge; SR Stone
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.
Nucleic acids research 1988;16(23):11366.
1988: SR Stone; R Mayer; W Wernet; F Maurer; Jan Hofsteenge; Brian A Hemmings
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit.
Nucleic acids research 1988;16(23):11365.
1988: Jan Hofsteenge; B Kieffer; R Matthies; Brian A Hemmings; SR Stone
Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats.
Biochemistry 1988;27(23):8537-44.
1988: Y Khew-Goodall; Brian A Hemmings
Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2A.
FEBS letters 1988;238(2):265-8.
1988: D A Jans; S H Botterell; Brian A Hemmings
Codominant expression of a mutation affecting the cAMP-dependent protein kinase catalytic subunit in somatic cell hybrids of LLC-PK1 cells.
Experimental cell research 1988;176(1):129-40.
1988: J Nakagawa; D von der Ahe; D Pearson; Brian A Hemmings; S Shibahara; Yoshikuni Nagamine
Transcriptional regulation of a plasminogen activator gene by cyclic AMP in a homologous cell-free system. Involvement of cyclic AMP-dependent protein kinase in transcriptional control.
The Journal of biological chemistry 1988;263(5):2460-8.
1988: D A Jans; Brian A Hemmings
cAMP metabolism in the porcine kidney epithelial cell line LLC-PK1: the central role of the cAMP-dependent protein kinase in cAMP-mediated gene induction.
Advances in second messenger and phosphoprotein research 1988;21():109-21.
1987: SR Stone; Jan Hofsteenge; Brian A Hemmings
Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.
Biochemistry 1987;26(23):7215-20.
1987: D A Jans; C Dierks-Ventling; Brian A Hemmings
Pathway of urokinase-type plasminogen activator induction in the T47D and LLC-PK1 cell lines.
Experimental cell research 1987;172(1):76-83.