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John Hempel

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John Hempel; Adam Kraut; Troy Wymore
Gamma glutamyl semialdehyde dehydrogenase: simulations on native and mutant forms support the importance of outer shell lysines.
Troy Wymore; David W Deerfield; John Hempel
Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations.
Troy Wymore; John Hempel; Samuel S Cho; Alexander D. Mackerell; Hugh B Nicholas; David W Deerfield
Molecular recognition of aldehydes by aldehyde dehydrogenase and mechanism of nucleophile activation.

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All Publications

2009: John Hempel; Adam Kraut; Troy Wymore
Gamma glutamyl semialdehyde dehydrogenase: simulations on native and mutant forms support the importance of outer shell lysines.
Chemico-biological interactions 2009;178(1-3):75-8.
2007: Troy Wymore; David W Deerfield; John Hempel
Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations.
Biochemistry 2007;46(33):9495-506.
2004: Troy Wymore; John Hempel; Samuel S Cho; Alexander D. Mackerell; Hugh B Nicholas; David W Deerfield
Molecular recognition of aldehydes by aldehyde dehydrogenase and mechanism of nucleophile activation.
Proteins 2004;57(4):758-71.
2003: Troy Wymore; David W Deerfield; Martin J Field; John Hempel; Hugh B Nicholas
Initial catalytic events in class 3 aldehyde dehydrogenase: MM and QM/MM simulations.
Chemico-biological interactions 2003;143-144():75-84.
2003: John Hempel; John Perozich; Troy Wymore; Hugh B Nicholas
An algorithm for identification and ranking of family-specific residues, applied to the ALDH3 family.
Chemico-biological interactions 2003;143-144():23-8.
2001: John Hempel; I Kuo; John Perozich; Bi-Cheng Wang; Ronald Lindahl; Hugh B Nicholas
Aldehyde dehydrogenase. Maintaining critical active site geometry at motif 8 in the class 3 enzyme.
European journal of biochemistry / FEBS 2001;268(3):722-6.
2001: Troy Wymore; Hugh B Nicholas; John Hempel
Molecular dynamics simulation of class 3 aldehyde dehydrogenase.
Chemico-biological interactions 2001;130-132(1-3):201-7.
2001: John Perozich; I Kuo; Ronald Lindahl; John Hempel
Coenzyme specificity in aldehyde dehydrogenase.
Chemico-biological interactions 2001;130-132(1-3):115-24.
2001: John Hempel; Ronald Lindahl; John Perozich; Bi-Cheng Wang; I Kuo; Hugh B Nicholas
Beyond the catalytic core of ALDH: a web of important residues begins to emerge.
Chemico-biological interactions 2001;130-132(1-3):39-46.
2000: Rhobert W Evans; BJ Shaten; John Hempel; JA Cutler; Lewis H Kuller
Homocyst(e)ine and risk of cardiovascular disease in the multiple risk factor intervention trial.
Indian heart journal 2000;52(7 Suppl):S44-52.
2000: John Perozich; I Kuo; Bi-Cheng Wang; Josette S Lindahl; Ronald Lindahl; John Hempel
Shifting the NAD/NADP preference in class 3 aldehyde dehydrogenase.
European journal of biochemistry / FEBS 2000;267(20):6197-203.
1999: John Hempel; John Perozich; T Chapman; J Rose; Josette S Lindahl; ZJ Liu; Ronald Lindahl; Bi-Cheng Wang
Aldehyde dehydrogenase catalytic mechanism. A proposal.
Advances in experimental medicine and biology 1999;463():53-9.
1999: John Perozich; Hugh B Nicholas; Ronald Lindahl; John Hempel
The big book of aldehyde dehydrogenase sequences. An overview of the extended family.
Advances in experimental medicine and biology 1999;463():1-7.
1999: John Perozich; Hugh B Nicholas; Bi-Cheng Wang; Ronald Lindahl; John Hempel
Relationships within the aldehyde dehydrogenase extended family.
Protein science : a publication of the Protein Society 1999;8(1):137-46.
1998: John Perozich; John Hempel; Sidney Morris
Roles of conserved residues in the arginase family.
Biochimica et biophysica acta 1998;1382(1):23-37.
1997: Rhobert W Evans; BJ Shaten; John Hempel; JA Cutler; Lewis H Kuller
Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):1947-53.
1997: Howard Wessel; S Anderson; D Fite; E Halvas; John Hempel; Nirmala SundarRaj
Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices.
Investigative ophthalmology & visual science 1997;38(11):2408-22.
1997: ZJ Liu; Y J Sun; J Rose; Y J Chung; C D Hsiao; W R Chang; I Kuo; John Perozich; Ronald Lindahl; John Hempel; Bi-Cheng Wang
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.
Nature structural biology 1997;4(4):317-26.
1997: Ken R Etzel; John Hempel; Richard R Koepsel
Identification of zinc proteins in rat parotid saliva.
Archives of oral biology 1997;42(2):173-9.
1997: John Hempel; ZJ Liu; John Perozich; J Rose; Ronald Lindahl; Bi-Cheng Wang
Conserved residues in the aldehyde dehydrogenase family. Locations in the class 3 tertiary structure.
Advances in experimental medicine and biology 1997;414():9-13.
1997: ZJ Liu; John Hempel; J Sun; J Rose; D Hsiao; W R Chang; Y J Chung; I Kuo; Ronald Lindahl; Bi-Cheng Wang
Crystal structure of a class 3 aldehyde dehydrogenase at 2.6 A resolution.
Advances in experimental medicine and biology 1997;414():1-7.
1995: Hugh B Nicholas; B Persson; H Jörnvall; John Hempel
Ethanol utilization regulatory protein: profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion.
Protein science : a publication of the Protein Society 1995;4(12):2621-4.
1995: John Perozich; A Leksana; John Hempel
UDP-glucose dehydrogenase. Structural characteristics.
Advances in experimental medicine and biology 1995;372():79-84.
1995: J Sun; John Hempel; Ronald Lindahl; John Perozich; J Rose; Bi-Cheng Wang
Progress toward the tertiary structure of (class 3) aldehyde dehydrogenase.
Advances in experimental medicine and biology 1995;372():71-7.
1994: John Hempel; John Perozich; H Romovacek; A Hinich; I Kuo; David Sidney Feingold
UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases.
Protein science : a publication of the Protein Society 1994;3(7):1074-80.
1993: John Hempel; Hugh B Nicholas; Ronald Lindahl
Aldehyde dehydrogenases: widespread structural and functional diversity within a shared framework.
Protein science : a publication of the Protein Society 1993;2(11):1890-900.
1993: D P Agarwal; R Eckey; John Hempel; H W Goedde
Human liver high Km aldehyde dehydrogenase (ALDH4): properties and structural relationship to the glutamic gamma-semialdehyde dehydrogenase.
Advances in experimental medicine and biology 1993;328():191-7.
1992: John Hempel; R Eckey; D Berie; H Romovacek; D P Agarwal; H W Goedde
Human liver glutamic gamma-semialdehyde dehydrogenase: structural relationship to the yeast enzyme.
Comparative biochemistry and physiology. B, Comparative biochemistry 1992;102(4):791-93.
1992: P Churchill; John Hempel; H Romovacek; W W Zhang; M Brennan; S Churchill
Primary structure of rat liver D-beta-hydroxybutyrate dehydrogenase from cDNA and protein analyses: a short-chain alcohol dehydrogenase.
Biochemistry 1992;31(15):3793-9.
1991: John Hempel; John P Rose; I Kuo; Ronald Lindahl; Bi-Cheng Wang
Rat class 3 aldehyde dehydrogenase: crystals and preliminary analysis.
Advances in experimental medicine and biology 1991;284():9-11.
1991: Ronald Lindahl; John Hempel
Aldehyde dehydrogenases: what can be learned from a baker's dozen sequences?
Advances in experimental medicine and biology 1991;284():1-8.
1991: R Eckey; R Timmann; John Hempel; D P Agarwal; H W Goedde
Biochemical, immunological, and molecular characterization of a "high Km" aldehyde dehydrogenase.
Advances in experimental medicine and biology 1991;284():43-52.
1991: John Hempel; Hugh B Nicholas; H Jörnvall
Thiol proteases and aldehyde dehydrogenases: evolution from a common thiolesterase precursor?
Proteins 1991;11(3):176-83.
1990: W F Diven; Barbara N Vietmeier; John Hempel; J Chambers
Purification and N-terminal characterization of Chinchilla villidera alpha-1-antitrypsin.
Comparative biochemistry and physiology. B, Comparative biochemistry 1990;95(1):39-44.
1990: John P Rose; John Hempel; I Kuo; Ronald Lindahl; Bi-Cheng Wang
Preliminary crystallographic analysis of class 3 rat liver aldehyde dehydrogenase.
Proteins 1990;8(4):305-8.
1989: John Hempel; K Harper; Ronald Lindahl
Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria.
Biochemistry 1989;28(3):1160-7.
1989: D P Agarwal; P Cohn; H W Goedde; John Hempel
Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme.
Enzyme 1989;42(1):47-52.
1989: John Hempel; Ronald Lindahl
Class III aldehyde dehydrogenase from rat liver: super-family relationship to classes I and II and functional interpretations.
Progress in clinical and biological research 1989;290():3-17.
1988: D E Jones; Mark D Brennan; John Hempel; R Lindahl
Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1782-6.
1987: John Hempel; J O Höög; H Jörnvall
Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data.
FEBS letters 1987;222(1):95-8.