Barbara Hempstead

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Greenberg Michael E; Xu Baoji; Lu Bai; Hempstead Barbara L
New insights in the biology of BDNF synthesis and release: implications in CNS function.
Hempstead Barbara L
Commentary: Regulating proNGF action: multiple targets for therapeutic intervention.
Yang Feng; Je Hyun-Soo; Ji Yuanyuan; Nagappan Guhan; Hempstead Barbara; Lu Bai
Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses.

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2009: Greenberg Michael E; Xu Baoji; Lu Bai; Hempstead Barbara L
New insights in the biology of BDNF synthesis and release: implications in CNS function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12764-7.
2009: Hempstead Barbara L
Commentary: Regulating proNGF action: multiple targets for therapeutic intervention.
Neurotoxicity research 2009;16(3):255-60.
2009: Yang Feng; Je Hyun-Soo; Ji Yuanyuan; Nagappan Guhan; Hempstead Barbara; Lu Bai
Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses.
The Journal of cell biology 2009;185(4):727-41.
2009: Nagappan Guhan; Zaitsev Eugene; Senatorov Vladimir V; Yang Jianmin; Hempstead Barbara L; Lu Bai
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1267-72.
2008: Volosin Marta; Trotter Christy; Cragnolini Andrea; Kenchappa Rajappa S; Light Matthew; Hempstead Barbara L; Carter Bruce D; Friedman Wilma J
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(39):9870-9.
2008: Truzzi Francesca; Marconi Alessandra; Lotti Roberta; Dallaglio Katiuscia; French Lars E; Hempstead Barbara L; Pincelli Carlo
Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.
The Journal of investigative dermatology 2008;128(8):2031-40.
2008: Bath Kevin G; Mandairon Nathalie; Jing Deqiang; Rajagopal Rithwick; Kapoor Ruchi; Chen Zhe-Yu; Khan Tanvir; Proenca Catia C; Kraemer Rosemary; Cleland Thomas A; Hempstead Barbara L; Chao Moses V; Lee Francis S
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(10):2383-93.
2007: Jansen Pernille; Giehl Klaus; Nyengaard Jens R; Teng Kenneth; Lioubinski Oleg; Sjoegaard Susanne S; Breiderhoff Tilman; Gotthardt Michael; Lin Fuyu; Eilers Andreas; Petersen Claus M; Lewin Gary R; Hempstead Barbara L; Willnow Thomas E; Nykjaer Anders
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Nature neuroscience 2007;10(11):1449-57.
2007: Johnston Angela L M; Lun Xueqing; Rahn Jennifer J; Liacini Abdelhamid; Wang Limei; Hamilton Mark G; Parney Ian F; Hempstead Barbara L; Robbins Stephen M; Forsyth Peter A; Senger Donna L
The p75 neurotrophin receptor is a central regulator of glioma invasion.
PLoS biology 2007;5(8):e212.
2007: Kermani Pouneh; Hempstead Barbara
Brain-derived neurotrophic factor: a newly described mediator of angiogenesis.
Trends in cardiovascular medicine 2007;17(4):140-3.
2007: Domeniconi Marco; Hempstead Barbara L; Chao Moses V
Pro-NGF secreted by astrocytes promotes motor neuron cell death.
Molecular and cellular neurosciences 2007;34(2):271-9.
2006: Turner Brian A; Sparrow Janet; Cai Bolin; Monroe Julie; Mikawa Takashi; Hempstead Barbara L
TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions.
Developmental biology 2006;299(2):455-65.
2006: Chen Zhe-Yu; Jing Deqiang; Bath Kevin G; Ieraci Alessandro; Khan Tanvir; Siao Chia-Jen; Herrera Daniel G; Toth Miklos; Yang Chingwen; McEwen Bruce S; Hempstead Barbara L; Lee Francis S
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.
Science (New York, N.Y.) 2006;314(5796):140-3.
2006: Ruan Jia; Hyjek Elizabeth; Kermani Pouneh; Christos Paul J; Hooper Andrea T; Coleman Morton; Hempstead Barbara; Leonard John P; Chadburn Amy; Rafii Shahin
Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5622-31.
2006: Volosin Marta; Song Wenyu; Almeida Ramiro D; Kaplan David R; Hempstead Barbara L; Friedman Wilma J
Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7756-66.
2006: Massa Stephen M; Xie Youmei; Yang Tao; Harrington Anthony W; Kim Mi Lyang; Yoon Sung Ok; Kraemer Rosemary; Moore Laura A; Hempstead Barbara L; Longo Frank M
Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(20):5288-300.
2006: Kenchappa Rajappa S; Zampieri Niccolò; Chao Moses V; Barker Philip A; Teng Henry K; Hempstead Barbara L; Carter Bruce D
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.
Neuron 2006;50(2):219-32.
2006: Hempstead Barbara L
Dissecting the diverse actions of pro- and mature neurotrophins.
Current Alzheimer research 2006;3(1):19-24.
2005: Kraemer Rosemary; Baker Peter James; Kent K Craig; Ye Yuanfen; Han Jun Ji; Tejada Rafael; Silane Michael; Upmacis Rita; Deeb Ruba; Chen Yaoxin; Levine Daniel M; Hempstead Barbara
Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse.
Circulation 2005;112(23):3644-53.
2005: Woo Newton H; Teng Henry K; Siao Chia-Jen; Chiaruttini Cristina; Pang Petti T; Milner Teresa A; Hempstead Barbara L; Lu Bai
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression.
Nature neuroscience 2005;8(8):1069-77.
2005: Chen Zhe-Yu; Ieraci Alessandro; Teng Henry; Dall Henning; Meng Chui-Xiang; Herrera Daniel G; Nykjaer Anders; Hempstead Barbara L; Lee Francis S
Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(26):6156-66.
2005: Teng Henry K; Teng Kenneth K; Lee Ramee; Wright Saundrene; Tevar Seema; Almeida Ramiro D; Kermani Pouneh; Torkin Risa; Chen Zhe-Yu; Lee Francis S; Kraemer Rosemary T; Nykjaer Anders; Hempstead Barbara L
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(22):5455-63.
2005: Pearse Roger N; Swendeman Steven L; Li Ying; Rafii Dahlia; Hempstead Barbara L
A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival.
Blood 2005;105(11):4429-36.
2005: Zhang Fan; Cheng Joseph; Lam George; Jin David K; Vincent Loïc; Hackett Neil R; Wang Shiyang; Young Lauren M; Hempstead Barbara; Crystal Ronald G; Rafii Shahin
Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways.
Circulation research 2005;96(9):950-7.
2005: Klein Mathias; Hempstead Barbara L; Teng Kenneth K
Activation of STAT5-dependent transcription by the neurotrophin receptor Trk.
Journal of neurobiology 2005;63(2):159-71.
2005: Hempstead Barbara L
Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5645-6.
2005: Linggi Michelle S; Burke Tara L; Williams B Blairanne; Harrington Anthony; Kraemer Rosemary; Hempstead Barbara L; Yoon Sung Ok; Carter Bruce D
Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor.
The Journal of biological chemistry 2005;280(14):13801-8.
2005: Kermani Pouneh; Rafii Dahlia; Jin David K; Whitlock Paul; Schaffer Wendy; Chiang Anne; Vincent Loic; Friedrich Matthias; Shido Koji; Hackett Neil R; Crystal Ronald G; Rafii Shahin; Hempstead Barbara L
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors.
The Journal of clinical investigation 2005;115(3):653-63.
2005: Shmelkov Sergey V; Meeus Sarah; Moussazadeh Nelson; Kermani Pouneh; Rashbaum William K; Rabbany Sina Y; Hanson Marilee A; Lane William J; St Clair Ryan; Walsh Kathryn A; Dias Sergio; Jacobson Jason T; Hempstead Barbara L; Edelberg Jay M; Rafii Shahin
Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue.
Circulation 2005;111(9):1175-83.
2005: Pedraza Carlos E; Podlesniy Petar; Vidal Noemí; Arévalo Juan Carlos; Lee Ramee; Hempstead Barbara; Ferrer Isidre; Iglesias Montse; Espinet Carme
Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR.
The American journal of pathology 2005;166(2):533-43.
2004: Pang Petti T; Teng Henry K; Zaitsev Eugene; Woo Newton T; Sakata Kazuko; Zhen Shushuang; Teng Kenneth K; Yung Wing-Ho; Hempstead Barbara L; Lu Bai
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.
Science (New York, N.Y.) 2004;306(5695):487-91.
2004: Srinivasan Bhooma; Roque Criselda H; Hempstead Barbara L; Al-Ubaidi Muayyad R; Roque Rouel S
Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor.
The Journal of biological chemistry 2004;279(40):41839-45.
2004: Kim Hyun; Li Qi; Hempstead Barbara L; Madri Joseph A
Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells.
The Journal of biological chemistry 2004;279(32):33538-46.
2004: Chen Zhe-Yu; Patel Paresh D; Sant Gayatree; Meng Chui-Xiang; Teng Kenneth K; Hempstead Barbara L; Lee Francis S
Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(18):4401-11.
2004: Harrington A W; Leiner B; Blechschmitt C; Arevalo J C; Lee R; Mörl K; Meyer M; Hempstead B L; Yoon S O; Giehl K M
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6226-30.
2004: Hempstead Barbara L
Sculpting organ innervation.
The Journal of clinical investigation 2004;113(6):811-3.
2004: Murray Simon S; Perez Pilar; Lee Ramee; Hempstead Barbara L; Chao Moses V
A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(11):2742-9.
2004: Nykjaer Anders; Lee Ramee; Teng Kenneth K; Jansen Pernille; Madsen Peder; Nielsen Morten S; Jacobsen Christian; Kliemannel Marco; Schwarz Elisabeth; Willnow Thomas E; Hempstead Barbara L; Petersen Claus M
Sortilin is essential for proNGF-induced neuronal cell death.
Nature 2004;427(6977):843-8.
2004: Teng K K; Hempstead B L
Neurotrophins and their receptors: signaling trios in complex biological systems.
Cellular and molecular life sciences : CMLS 2004;61(1):35-48.
2004: Ling Qi; Jacovina Andrew T; Deora Arunkumar; Febbraio Maria; Simantov Ronit; Silverstein Roy L; Hempstead Barbara; Mark Willie H; Hajjar Katherine A
Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo.
The Journal of clinical investigation 2004;113(1):38-48.
2004: Zhou Hong-Ming; Weskamp Gisela; Chesneau Valérie; Sahin Umut; Vortkamp Andrea; Horiuchi Keisuke; Chiusaroli Riccardo; Hahn Rebecca; Wilkes David; Fisher Peter; Baron Roland; Manova Katia; Basson Craig T; Hempstead Barbara; Blobel Carl P
Essential role for ADAM19 in cardiovascular morphogenesis.
Molecular and cellular biology 2004;24(1):96-104.
2003: Kraemer Rosemary; Hempstead Barbara L
Neurotrophins: novel mediators of angiogenesis.
Frontiers in bioscience : a journal and virtual library 2003;8():s1181-6.
2003: Shonukan Oluwatoyin; Bagayogo Issa; McCrea Pierre; Chao Moses; Hempstead Barbara
Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin.
Oncogene 2003;22(23):3616-23.
2002: Hempstead Barbara L; Salzer James L
Neurobiology. A glial spin on neurotrophins.
Science (New York, N.Y.) 2002;298(5596):1184-6.
2002: Beattie Michael S; Harrington Anthony W; Lee Ramee; Kim Ju Young; Boyce Sheri L; Longo Frank M; Bresnahan Jacqueline C; Hempstead Barbara L; Yoon Sung Ok
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.
Neuron 2002;36(3):375-86.
2002: Hempstead Barbara L
The many faces of p75NTR.
Current opinion in neurobiology 2002;12(3):260-7.
2002: Yu Xiaobing; Shacka John J; Eells Jeffrey B; Suarez-Quian Carlos; Przygodzki Ronald M; Beleslin-Cokic Bojana; Lin Chyuan-Sheng; Nikodem Vera M; Hempstead Barbara; Flanders Kathleen C; Costantini Frank; Noguchi Constance Tom
Erythropoietin receptor signalling is required for normal brain development.
Development (Cambridge, England) 2002;129(2):505-16.
2001: Lee R; Kermani P; Teng K K; Hempstead B L
Regulation of cell survival by secreted proneurotrophins.
Science (New York, N.Y.) 2001;294(5548):1945-8.
2001: Esposito D; Patel P; Stephens R M; Perez P; Chao M V; Kaplan D R; Hempstead B L
The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor.
The Journal of biological chemistry 2001;276(35):32687-95.
2000: Donovan M J; Lin M I; Wiegn P; Ringstedt T; Kraemer R; Hahn R; Wang S; Ibañez C F; Rafii S; Hempstead B L
Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization.
Development (Cambridge, England) 2000;127(21):4531-40.
2000: Lin M I; Das I; Schwartz G M; Tsoulfas P; Mikawa T; Hempstead B L
Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo.
Developmental biology 2000;226(2):180-91.
2000: Wang S; Bray P; McCaffrey T; March K; Hempstead B L; Kraemer R
p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells.
The American journal of pathology 2000;157(4):1247-58.
2000: Arevalo J C; Conde B; Hempstead B L; Chao M V; Martin-Zanca D; Perez P
TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor.
Molecular and cellular biology 2000;20(16):5908-16.
2000: Escalante M; Courtney J; Chin W G; Teng K K; Kim J I; Fajardo J E; Mayer B J; Hempstead B L; Birge R B
Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis.
The Journal of biological chemistry 2000;275(32):24787-97.
2000: Das I; Sparrow J R; Lin M I; Shih E; Mikawa T; Hempstead B L
Trk C signaling is required for retinal progenitor cell proliferation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(8):2887-95.
1999: Teng K K; Esposito D K; Schwartz G D; Lander H M; Hempstead B L
Activation of c-Ha-Ras by nitric oxide modulates survival responsiveness in neuronal PC12 cells.
The Journal of biological chemistry 1999;274(52):37315-20.
1997: Tessarollo L; Tsoulfas P; Donovan M J; Palko M E; Blair-Flynn J; Hempstead B L; Parada L F
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14776-81.
1997: Das I; Hempstead B L; MacLeish P R; Sparrow J R
Immunohistochemical analysis of the neurotrophins BDNF and NT-3 and their receptors trk B, trk C, and p75 in the developing chick retina.
Visual neuroscience 1997;14(5):835-42.
1997: Lander H M; Hajjar D P; Hempstead B L; Mirza U A; Chait B T; Campbell S; Quilliam L A
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction.
The Journal of biological chemistry 1997;272(7):4323-6.
1996: Lander H M; Milbank A J; Tauras J M; Hajjar D P; Hempstead B L; Schwartz G D; Kraemer R T; Mirza U A; Chait B T; Burk S C; Quilliam L A
Redox regulation of cell signalling.
Nature 1996;381(6581):380-1.
1996: Teng K K; Courtney J C; van Bergen en Henegouwen P; Birge R B; Hempstead B L
Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-Crk in PC12 cells.
Molecular and cellular neurosciences 1996;8(2-3):157-70.
1995: Teng K K; Lander H; Fajardo J E; Hanafusa H; Hempstead B L; Birge R B
v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway.
The Journal of biological chemistry 1995;270(35):20677-85.
1994: Mahadeo D; Kaplan L; Chao M V; Hempstead B L
High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.
The Journal of biological chemistry 1994;269(9):6884-91.
1994: Hempstead B L; Birge R B; Fajardo J E; Glassman R; Mahadeo D; Kraemer R; Hanafusa H
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.
Molecular and cellular biology 1994;14(3):1964-71.
1993: Horvath C M; Wolven A; Machadeo D; Huber J; Boter L; Benedetti M; Hempstead B; Chao M V
Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins.
Journal of cell science. Supplement 1993;17():223-8.
1991: Berg M M; Sternberg D W; Hempstead B L; Chao M V
The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7106-10.

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Barbara Hempstead

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