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René Hen

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Maura Boldrini; Andrew J Dwork; René Hen; Gorazd B Rosoklija; Adrienne N Santiago; Hadassah Tamir; Victoria Arango; J John Mann
Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression.
Mazen A Kheirbek; Lindsay Tannenholz; Hongkui Zeng; Susanne E Ahmari; Nesha S Burghardt; Daniel O Costantini; Liam J Drew; André A Fenton; René Hen
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.
Melody V Wu; René Hen
The young and the restless: regulation of adult neurogenesis by Wnt signaling.

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2013: Maura Boldrini; Andrew J Dwork; René Hen; Gorazd B Rosoklija; Adrienne N Santiago; Hadassah Tamir; Victoria Arango; J John Mann
Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(6):1068-77.
2013: Mazen A Kheirbek; Lindsay Tannenholz; Hongkui Zeng; Susanne E Ahmari; Nesha S Burghardt; Daniel O Costantini; Liam J Drew; André A Fenton; René Hen
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.
Neuron 2013;77(5):955-68.
2013: Melody V Wu; René Hen
The young and the restless: regulation of adult neurogenesis by Wnt signaling.
Cell stem cell 2013;12(2):139-40.
2012: Mazen A Kheirbek; Kristen C Klemenhagen; Amar Sahay; René Hen
Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders.
Nature neuroscience 2012;15(12):1613-20.
2012: Maurizio Fava; Fred H Gage; René Hen; Andrew A Nierenberg; Steven D Targum; Pamela C Wedel; Leo S Bleicher; Todd A Carter; Carrolee Barlow
An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery.
Journal of psychiatric research 2012;46(12):1553-63.
2012: Maura Boldrini; Andrew J Dwork; René Hen; J John Mann; Gorazd Rosoklija; Mark D Underwood; Victoria Arango
Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression.
Biological psychiatry 2012;72(7):562-71.
2012: Nesha S Burghardt; René Hen; Eun Hye Park; André A Fenton
Adult-born hippocampal neurons promote cognitive flexibility in mice.
Hippocampus 2012;22(9):1795-808.
2012: Mazen A Kheirbek; Lindsay Tannenholz; René Hen
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(25):8696-702.
2012: Christine A Denny; René Hen; Daniel M Schachter; Nesha S Burghardt; Michael R Drew
4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning.
Hippocampus 2012;22(5):1188-201.
2012: David H Gire; René Hen; Abigail A Mulligan; Kenji F Tanaka; Jennifer D Whitesell; Joseph D Zak; Kevin M Franks; Nathan E Schoppa
Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(9):2964-75.
2011: Benjamin Adam Samuels; Amanda Williams; Erik H F Wong; Jin Zhou; Denis J David; Reto Gadient; Alain Michel Gardier; Eduardo David Leonardo; René Hen
Modeling treatment-resistant depression.
Neuropharmacology 2011;61(3):408-13.
2011: Amar Sahay; Kimberly N Scobie; Alexis S Hill; Colin M O'Carroll; Mazen A Kheirbek; Nesha S Burghardt; André A Fenton; Alex Dranovsky; René Hen
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.
Nature 2011;472(7344):466-70.
2011: Jesse W Richardson-Jones; Thanh H Nguyen; Sheryl G Beck; Caryne P Craige; Denis J David; Alex Dranovsky; Alain M Gardier; Bruno P Guiard; René Hen; Hank F Kung; E David Leonardo
Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(16):6008-18.
2011: Benjamin A Samuels; René Hen
Neurogenesis and affective disorders.
The European journal of neuroscience 2011;33(6):1152-9.
2011: Nao Chuhma; Kenji F Tanaka; René Hen; Stephen Rayport
Functional connectome of the striatal medium spiny neuron.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(4):1183-92.
2010: Denis J David; Jingwen Wang; Benjamin Adam Samuels; Quentin Rainer; Indira David; Alain M Gardier; René Hen
Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2010;16(5):578-91.
2010: Jesse W Richardson-Jones; Caryne P Craige; Bruno P Guiard; Alisson Stephen; Kayla L Metzger; Hank F Kung; Alain M Gardier; Alex Dranovsky; Denis J David; Sheryl G Beck; René Hen; E David Leonardo
5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants.
Neuron 2010;65(1):40-52.
2009: Inna Gaisler-Salomon; Gretchen M Miller; Nao Chuhma; Sooyeon Lee; Hong Zhang; Farhad Ghoddoussi; Nicole Lewandowski; Stephen Fairhurst; Yvonne Wang; Agnès Conjard-Duplany; Justine Masson; Peter Balsam; René Hen; Ottavio Arancio; matthew galloway; Holly M Moore; Scott Small; Stephen Rayport
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(10):2305-22.
2009: Kimberly N Scobie; Benjamin J Hall; Scott A Wilke; Kristen C Klemenhagen; Yoshiaki Fujii-Kuriyama; Anirvan Ghosh; René Hen; Amar Sahay
Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(31):9875-87.
2009: Min-tsai Liu; Yung-Hui Kuan; Jingwen Wang; René Hen; Michael D Gershon
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(31):9683-99.
2009: Thierry Deltheil; Kenji Tanaka; Christelle Reperant; René Hen; Denis J David; Alain M Gardier
Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(7):905-15.
2008: Vijay Yadav; Je-Hwang Ryu; Nina Suda; Kenji F Tanaka; Jay A Gingrich; Günther Schütz; Francis H Glorieux; Cherie Y Chiang; Jeffrey D Zajac; Karl L Insogna; J John Mann; René Hen; Patricia Ducy; Gerard Karsenty
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.
Cell 2008;135(5):825-37.
2008: Alexandre Surget; Michael Saxe; Samuel Leman; Yadira Ibarguen-Vargas; Sylvie Chalon; Guy Griebel; René Hen; Catherine Belzung
Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal.
Biological psychiatry 2008;64(4):293-301.
2008: Jing-Wen Wang; Alex Dranovsky; René Hen
The when and where of BDNF and the antidepressant response.
Biological psychiatry 2008;63(7):640-1.
2008: Jing-Wen Wang; Denis J David; James E Monckton; Fortunato Battaglia; René Hen
Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(6):1374-84.
2008: Bruno P Guiard; Denis J P David; Thierry Deltheil; Franck CHENU; Erwan Le Maître; Thibault Renoir; Isabelle Leroux-Nicollet; Pierre Sokoloff; Laurence Lanfumey; Michel Hamon; Anne M Andrews; René Hen; Alain M Gardier
Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2008;11(1):79-92.
2008: Amar Sahay; René Hen
Hippocampal neurogenesis and depression.
Novartis Foundation symposium 2008;289():152-60; discussion 160-4, 193-5.
2008: E David Leonardo; René Hen
Anxiety as a developmental disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(1):134-40.
2008: Kerri A Holick; Daniel C Lee; René Hen; Stephanie C Dulawa
Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(2):406-17.
2007: Amy Cecilia Sanders; Ali J Hussain; René Hen; Xiaoxi Zhuang
Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(11):2321-9.
2007: Alexandra Jean; Grégory Conductier; Christine Manrique; Constantin Bouras; Philippe Berta; René Hen; Yves Charnay; Joël Bockaert; Valérie COMPAN
Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16335-40.
2007: Alex Dranovsky; René Hen
DISC1 puts the brakes on neurogenesis.
Cell 2007;130(6):981-3.
2007: Amar Sahay; René Hen
Adult hippocampal neurogenesis in depression.
Nature neuroscience 2007;10(9):1110-5.
2007: Michael R Drew; René Hen
Adult hippocampal neurogenesis as target for the treatment of depression.
CNS & neurological disorders drug targets 2007;6(3):205-18.
2007: Tarique Perera; Jeremy D Coplan; Sarah H Lisanby; Cecilia M Lipira; Mohamed Arif; Cristina Carpio; Gila Spitzer; Luca Santarelli; Bruce Scharf; René Hen; Gorazd Rosoklija; Harold A Sackeim; andrew dwork
Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(18):4894-901.
2007: Denis J David; Kristen C Klemenhagen; K A Holick; Michael D Saxe; I Mendez; Luca Santarelli; Douglas A Craig; H Zhong; Chad J Swanson; Laxminarayan G Hegde; X I Ping; D Dong; Mohammad R Marzabadi; Christophe Gerald; René Hen
Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis.
The Journal of pharmacology and experimental therapeutics 2007;321(1):237-48.
2007: Gabriella Gobbi; Tommaso Cassano; Fatiha Radja; Maria Grazia Morgese; Vincenzo Cuomo; Luca Santarelli; René Hen; Pierre Blier
Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(5):328-38.
2007: Ana C Pereira; Dan E Huddleston; Adam Brickman; Alexander A Sosunov; René Hen; Guy M McKhann; Richard Sloan; Fred H Gage; Truman R Brown; Scott Small
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5638-43.
2007: Michael D Saxe; Gaël Malleret; Svetlana Vronskaya; Indira Mendez; A Denise R Garcia; Michael V Sofroniew; Eric R Kandel; René Hen
Paradoxical influence of hippocampal neurogenesis on working memory.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4642-6.
2007: Mark Ansorge; René Hen; Jay A Gingrich
Neurodevelopmental origins of depressive disorders.
Current opinion in pharmacology 2007;7(1):8-17.
2007: Helen E Scharfman; René Hen
Neuroscience. Is more neurogenesis always better?
Science (New York, N.Y.) 2007;315(5810):336-8.
2007: Amar Sahay; Michael R Drew; René Hen
Dentate gyrus neurogenesis and depression.
Progress in brain research 2007;163():697-722.
2007: KL Stark; C Gross; J Richardson-Jones; X Zhuang; René Hen
A novel conditional knockout strategy applied to serotonin receptors.
Handbook of experimental pharmacology 2007;(178):347-63.
2006: Michael D Saxe; Fortunato Battaglia; Jing-Wen Wang; Gaël Malleret; Denis J David; James E Monckton; A Denise R Garcia; Michael V Sofroniew; Eric R Kandel; Luca Santarelli; René Hen; Michael R Drew
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17501-6.
2006: Joshua A Gordon; René Hen
TREKing toward new antidepressants.
Nature neuroscience 2006;9(9):1081-3.
2006: Grégory Conductier; Nicole Dusticier; Guillaume Lucas; Francine Côté; Guy Debonnel; Annie Daszuta; Aline Dumuis; André Nieoullon; René Hen; Joël Bockaert; Valérie COMPAN
Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse.
The European journal of neuroscience 2006;24(4):1053-62.
2006: Noelia Weisstaub; Mingming Zhou; Alena Lira; Evelyn Lambe; Javier González-Maeso; Jean-Pierre Hornung; Etienne Sibille; Mark Underwood; Shigeyoshi Itohara; William T Dauer; Mark Ansorge; Emanuela Morelli; J John Mann; Miklos Toth; George Aghajanian; Stuart C Sealfon; René Hen; Jay A Gingrich
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.
Science (New York, N.Y.) 2006;313(5786):536-40.
2006: Alex Dranovsky; René Hen
Hippocampal neurogenesis: regulation by stress and antidepressants.
Biological psychiatry 2006;59(12):1136-43.
2006: Dar Meshi; Michael R Drew; Michael D Saxe; Mark Ansorge; Denis David; Luca Santarelli; Chara Malapani; Holly Moore; René Hen
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment.
Nature neuroscience 2006;9(6):729-31.
2006: Justine Masson; Michèle Darmon; Agnès Conjard-Duplany; Nao Chuhma; Nicole Ropert; Muriel Thoby-Brisson; Arthur S Foutz; Sandrine Parrot; Gretchen M Miller; Renée Jorisch; Jonathan Polan; Michel Hamon; René Hen; Stephen Rayport
Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4660-71.
2006: E David Leonardo; René Hen
Genetics of affective and anxiety disorders.
Annual review of psychology 2006;57():117-37.
2006: E David Leonardo; J W Richardson-Jones; Etienne Sibille; Andreas Kottmann; René Hen
Molecular heterogeneity along the dorsal-ventral axis of the murine hippocampal CA1 field: a microarray analysis of gene expression.
Neuroscience 2006;137(1):177-86.
2006: Kristen C Klemenhagen; Joshua A Gordon; Denis J David; René Hen; Cornelius T Gross
Increased fear response to contextual cues in mice lacking the 5-HT1A receptor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(1):101-11.
2005: Nicola Clayton; René Hen
Neural circuits and behaviour: developmental and evolutionary perspectives.
Current opinion in neurobiology 2005;15(6):683-5.
2005: Martin B Keller; John H Krystal; René Hen; Alexander Neumeister; Naomi M Simon
Untangling depression and anxiety: clinical challenges.
The Journal of clinical psychiatry 2005;66(11):1477-84.
2005: Joshua A Gordon; Clay O Lacefield; Clifford G Kentros; René Hen
State-dependent alterations in hippocampal oscillations in serotonin 1A receptor-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(28):6509-19.
2005: Grégory Conductier; Cyril Crosson; René Hen; Joël Bockaert; Valérie COMPAN
3,4-N-methlenedioxymethamphetamine-induced hypophagia is maintained in 5-HT1B receptor knockout mice, but suppressed by the 5-HT2C receptor antagonist RS102221.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(6):1056-63.
2005: Xiaoxi Zhuang; Justine Masson; Jay A Gingrich; Stephen Rayport; René Hen
Targeted gene expression in dopamine and serotonin neurons of the mouse brain.
Journal of neuroscience methods 2005;143(1):27-32.
2005: Fiona Doetsch; René Hen
Young and excitable: the function of new neurons in the adult mammalian brain.
Current opinion in neurobiology 2005;15(1):121-8.
2005: Stephanie C Dulawa; René Hen
Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test.
Neuroscience and biobehavioral reviews 2005;29(4-5):771-83.
2004: Amit Etkin; Kristen C Klemenhagen; Joshua T Dudman; michael rogan; René Hen; Eric R Kandel; Joy Hirsch
Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces.
Neuron 2004;44(6):1043-55.
2004: Mathieu Wolff; Pierre Costet; Cornelius Gross; René Hen; Louis Segu; Marie-Christine Buhot
Age-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice.
Brain research. Molecular brain research 2004;130(1-2):39-48.
2004: Mark Ansorge; Mingming Zhou; Alena Lira; René Hen; Jay A Gingrich
Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice.
Science (New York, N.Y.) 2004;306(5697):879-81.
2004: Bassem F El-Khodor; Miriam Hernandez Dimmler; Djamel Ait Amara; Myron Hofer; René Hen; Dani Brunner
Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004;22(5-6):405-13.
2004: Cornelius Gross; René Hen
The developmental origins of anxiety.
Nature reviews. Neuroscience 2004;5(7):545-52.
2004: Stephanie C Dulawa; Kerri A Holick; Brigitta Gundersen; René Hen
Effects of chronic fluoxetine in animal models of anxiety and depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(7):1321-30.
2004: Pierre Blier; Gabriella Gobbi; Nasser Haddjeri; Luca Santarelli; Gina Mathew; René Hen
Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response.
Journal of psychiatry & neuroscience : JPN 2004;29(3):208-18.
2004: Clotilde Mannoury La Cour; Naïma Hanoun; Maxette Melfort; René Hen; Klaus-Peter Lesch; Michel Hamon; Laurence Lanfumey
GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors.
Journal of neurochemistry 2004;89(4):886-96.
2004: Prakasham Rumajogee; Daniel Vergé; Naïma Hanoun; Marie-Jeanne Brisorgueil; René Hen; Klaus-Peter Lesch; Michel Hamon; Marie-Christine Miquel
Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP.
The European journal of neuroscience 2004;19(4):937-44.
2004: Nao Chuhma; Hui Zhang; Justine Masson; Xiaoxi Zhuang; David Sulzer; René Hen; Stephen Rayport
Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(4):972-81.
2004: Valérie COMPAN; Mingming Zhou; Regis Grailhe; Russell Gazzara; Renee Martin; Jay A Gingrich; Aline Dumuis; Daniela Brunner; Joël Bockaert; René Hen
Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(2):412-9.
2004: Cornelius Gross; René Hen
Genetic and environmental factors interact to influence anxiety.
Neurotoxicity research 2004;6(6):493-501.
2004: Joshua A Gordon; René Hen
Genetic approaches to the study of anxiety.
Annual review of neuroscience 2004;27():193-222.
2004: Valérie COMPAN; Yves Charnay; Nicole Dusticier; Annie Daszuta; René Hen; Joël Bockaert
[Feeding disorders in 5-HT4 receptor knockout mice].
Journal de la Société de biologie 2004;198(1):37-49.
2004: Joshua A Gordon; René Hen
The serotonergic system and anxiety.
Neuromolecular medicine 2004;5(1):27-40.
2003: Alena Lira; Mingming Zhou; Nathalie Castanon; Mark Ansorge; Joshua A Gordon; Jasmine H Francis; Maria Bradley-Moore; Josko Lira; Mark D Underwood; Victoria Arango; Hank F Kung; Myron Arms Hofer; René Hen; Jay A Gingrich
Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice.
Biological psychiatry 2003;54(10):960-71.
2003: Marie-Christine Buhot; Mathieu Wolff; Narimane Benhassine; Pierre Costet; René Hen; Louis Segu
Spatial learning in the 5-HT1B receptor knockout mouse: selective facilitation/impairment depending on the cognitive demand.
Learning & memory (Cold Spring Harbor, N.Y.) 2003;10(6):466-77.
2003: Javier González-Maeso; Tony Yuen; Barbara J Ebersole; Elisa Wurmbach; Alena Lira; Mingming Zhou; Noelia Weisstaub; René Hen; Jay A Gingrich; Stuart C Sealfon
Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8836-43.
2003: Mathieu Wolff; Narimane Benhassine; Pierre Costet; René Hen; Louis Segu; Marie-Christine Buhot
Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze.
Learning & memory (Cold Spring Harbor, N.Y.) 2003;10(5):401-9.
2003: Luca Santarelli; Michael D Saxe; Cornelius Gross; Alexandre Surget; Fortunato Battaglia; Stephanie Dulawa; Noelia Weisstaub; James T Lee; Ronald Duman; Ottavio Arancio; Catherine Belzung; René Hen
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.
Science (New York, N.Y.) 2003;301(5634):805-9.
2003: Valérie COMPAN; Kimberly Scearce-Levie; C Crosson; Annie Daszuta; René Hen
Enkephalin contributes to the locomotor stimulating effects of 3,4-methylenedioxy-N-methylamphetamine.
The European journal of neuroscience 2003;18(2):383-90.
2003: Alain M Gardier; Denis Joseph Paul David; Gaelle Jego; Cédric Przybylski; Christian Jacquot; S Durier; B Gruwez; E Douvier; Patrick Beauverie; Nicole Poisson; René Hen; Michel Bourin
Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice.
Journal of neurochemistry 2003;86(1):13-24.
2003: Marie-Christine Buhot; Mathieu Wolff; Magdaléna Savova; Gaël Malleret; René Hen; Louis Segu
Protective effect of 5-HT1B receptor gene deletion on the age-related decline in spatial learning abilities in mice.
Behavioural brain research 2003;142(1-2):135-42.
2003: Christelle Monaca; Benjamin Boutrel; René Hen; Michel Hamon; Joëlle Adrien
5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(5):850-6.
2003: Aron Weller; Ana Christina Leguisamo; Lorraine Towns; Sylvie Ramboz; Emilia Bagiella; Myron Hofer; René Hen; Dani Brunner
Maternal effects in infant and adult phenotypes of 5HT1A and 5HT1B receptor knockout mice.
Developmental psychobiology 2003;42(2):194-205.
2003: Mathieu Wolff; Magdaléna Savova; Gaël Malleret; René Hen; Louis Segu; Marie-Christine Buhot
Serotonin 1B knockout mice exhibit a task-dependent selective learning facilitation.
Neuroscience letters 2003;338(1):1-4.
2003: Rebecca J Ralph-Williams; Martin P Paulus; Xiaoxi Zhuang; René Hen; Mark A Geyer
Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system.
Biological psychiatry 2003;53(4):352-9.
2003: Douglas Wahlsten; Pamela Metten; Tamara J Phillips; Stephen L Boehm; Sue Burkhart-Kasch; Janet Dorow; Sharon Doerksen; Chris Downing; Jennifer Fogarty; Kristina Rodd-Henricks; René Hen; Carrie S McKinnon; Catherine M Merrill; Cedar Nolte; Melike Schalomon; Jason P Schlumbohm; Jason R Sibert; Charlotte D Wenger; Bruce C Dudek; John C Crabbe
Different data from different labs: lessons from studies of gene-environment interaction.
Journal of neurobiology 2003;54(1):283-311.
2002: William T Dauer; Nikolai Kholodilov; Miquel Vila; Anne-Cecile Trillat; Rose E Goodchild; Kristin Larsen; Roland G W Staal; Kim Tieu; Yvonne Schmitz; Chao Annie Yuan; Marcelo Rocha; Vernice Jackson-Lewis; Steven M Hersch; David Sulzer; Serge Przedborski; Robert Burke; René Hen
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14524-9.
2002: Gabriela Rodríguez-Manzo; Carolina López-Rubalcava; René Hen; Alonso Fernández-Guasti
Participation of 5-HT(1B) receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5-HT(1B) receptor knockout mice.
British journal of pharmacology 2002;136(8):1127-34.
2002: Pascal Bonaventure; Diane Nepomuceno; Annette Kwok; Wenying Chai; Xavier Langlois; René Hen; Kimberly Stark; Nicholas I Carruthers; Timothy W Lovenberg
Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice.
The Journal of pharmacology and experimental therapeutics 2002;302(1):240-8.
2002: Benjamin Boutrel; Christelle Monaca; René Hen; Michel Hamon; Joëlle Adrien
Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(11):4686-92.
2002: Isabelle Malagié; Denis Joseph Paul David; Pascale Jolliet; René Hen; Michel Bourin; Alain M Gardier
Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT(1B) receptor knock-out mice.
European journal of pharmacology 2002;443(1-3):99-104.
2002: Elena Fiorica-Howells; René Hen; Jay A Gingrich; Zhishan Li; Michael D Gershon
5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(5):G877-93.
2002: Cornelius Gross; Xiaoxi Zhuang; Kimberly Stark; Sylvie Ramboz; Ronald Oosting; Lynn Kirby; Luca Santarelli; Sheryl Beck; René Hen
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.
Nature 2002;416(6879):396-400.
2002: Maxime Richer; René Hen; Pierre Blier
Modification of serotonin neuron properties in mice lacking 5-HT1A receptors.
European journal of pharmacology 2002;435(2-3):195-203.
2002: Luca Santarelli; Gabriella Gobbi; Pierre Blier; René Hen
Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).
The Journal of clinical psychiatry 2002;63 Suppl 11():11-7.
2002: Adriaan Bouwknecht; Theo Hijzen; Jan van der Gugten; Robert A A Maes; René Hen; Berend Olivier
5-HT(1B) receptor knockout mice show no adaptive changes in 5-HT(1A) receptor function as measured telemetrically on body temperature and heart rate responses.
Brain research bulletin 2002;57(1):93-102.
2001: A Yamamoto; René Hen; William T Dauer
The ons and offs of inducible transgenic technology: a review.
Neurobiology of disease 2001;8(6):923-32.
2001: Etienne Sibille; René Hen
Combining genetic and genomic approaches to study mood disorders.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2001;11(6):413-21.
2001: Adriaan Bouwknecht; Jan van der Gugten; Theo Hijzen; Robert A A Maes; René Hen; Berend Olivier
Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes.
Physiology & behavior 2001;74(4-5):507-16.
2001: Etienne Sibille; René Hen
Serotonin(1A) receptors in mood disorders: a combined genetic and genomic approach.
Behavioural pharmacology 2001;12(6-7):429-38.
2001: Alain M Gardier; B Gruwez; AC Trillat; Christian Jacquot; René Hen; Michel Bourin
Interaction between 5-HT(1A) and 5-HT(1B) receptors: effects of 8-OH-DPAT-induced hypothermia in 5-HT(1B) receptor knockout mice.
European journal of pharmacology 2001;421(3):171-5.
2001: Alain M Gardier; AC Trillat; Isabelle Malagié; D David; Martine Hascoët; Marie Claude Colombel; Pascale Jolliet; Christian Jacquot; René Hen; Michel Bourin
[5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors ].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 2001;324(5):433-41.
2001: Regis Grailhe; G W Grabtree; René Hen
Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution.
European journal of pharmacology 2001;418(3):157-67.
2001: Jay A Gingrich; René Hen
Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice.
Psychopharmacology 2001;155(1):1-10.
2001: Tommy Pattij; Theo Hijzen; Lucianne Groenink; Ronald S Oosting; Jan van der Gugten; Robert A A Maes; René Hen; Berend Olivier
Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal.
Biological psychiatry 2001;49(7):569-74.
2001: Adriaan Bouwknecht; Theo Hijzen; Jan van der Gugten; Robert A A Maes; René Hen; Berend Olivier
Absence of 5-HT(1B) receptors is associated with impaired impulse control in male 5-HT(1B) knockout mice.
Biological psychiatry 2001;49(7):557-68.
2001: Xiaoxi Zhuang; Ronald Oosting; S R Jones; R R Gainetdinov; Gary Miller; Marc G Caron; René Hen
Hyperactivity and impaired response habituation in hyperdopaminergic mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1982-7.
2001: Luca Santarelli; G Gobbi; P C Debs; E T Sibille; Pierre Blier; René Hen; M J Heath
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1912-7.
2001: Adriaan Bouwknecht; Jan van der Gugten; Theo Hijzen; Robert A A Maes; René Hen; Berend Olivier
Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal.
Psychopharmacology 2001;153(4):484-90.
2001: Isabelle Malagié; AC Trillat; Michel Bourin; Christian Jacquot; René Hen; Alain M Gardier
5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex.
Journal of neurochemistry 2001;76(3):865-71.
2001: Anneloes Dirks; Tommy Pattij; Adriaan Bouwknecht; T T Westphal; Theo Hijzen; Lucianne Groenink; Jan van der Gugten; Ronald S Oosting; René Hen; Mark A Geyer; Berend Olivier
5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response.
Behavioural brain research 2001;118(2):169-78.
2000: Adriaan Bouwknecht; Theo Hijzen; Jan van der Gugten; Anneloes Dirks; Robert A A Maes; René Hen; Mark A Geyer; Berend Olivier
Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice.
Neuroreport 2000;11(18):4097-102.
2000: Cornelius Gross; Luca Santarelli; Dani Brunner; Xiaoxi Zhuang; René Hen
Altered fear circuits in 5-HT(1A) receptor KO mice.
Biological psychiatry 2000;48(12):1157-63.
2000: N Castanon; Kimberly Scearce-Levie; J J Lucas; Beatriz A Rocha; René Hen
Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.
Pharmacology, biochemistry, and behavior 2000;67(3):559-66.
2000: Carolina López-Rubalcava; René Hen; Silvia L Cruz
Anxiolytic-like actions of toluene in the burying behavior and plus-maze tests: differences in sensitivity between 5-HT(1B) knockout and wild-type mice.
Behavioural brain research 2000;115(1):85-94.
2000: Adriaan Bouwknecht; Theo Hijzen; Jan van der Gugten; Robert A A Maes; René Hen; Berend Olivier
Ethanol intake is not elevated in male 5-HT(1B) receptor knockout mice.
European journal of pharmacology 2000;403(1-2):95-8.
2000: Xiaoxi Zhuang; L Belluscio; René Hen
G(olf)alpha mediates dopamine D1 receptor signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(16):RC91.
2000: A Yamamoto; J J Lucas; René Hen
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.
Cell 2000;101(1):57-66.
2000: Jay A Gingrich; René Hen
The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice.
Current opinion in neurobiology 2000;10(1):146-52.
1999: Alexis Evrard; AM Laporte; M Chastanet; René Hen; Michel Hamon; Joëlle Adrien
5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice.
The European journal of neuroscience 1999;11(11):3823-31.
1999: Xiaoxi Zhuang; Cornelius Gross; Luca Santarelli; Valérie COMPAN; Anne-Cecile Trillat; René Hen
Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(2 Suppl):52S-60S.
1999: Gaël Malleret; René Hen; jean-louis guillou; Louis Segu; Marie-Christine Buhot
5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):6157-68.
1999: Kimberly Scearce-Levie; J P Chen; E Gardner; René Hen
5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.
Annals of the New York Academy of Sciences 1999;868():701-15.
1999: Benjamin Boutrel; B Franc; René Hen; Michel Hamon; Joëlle Adrien
Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(8):3204-12.
1999: Regis Grailhe; Christian Waeber; S C Dulawa; J P Hornung; Xiaoxi Zhuang; D Brunner; Mark A Geyer; René Hen
Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor.
Neuron 1999;22(3):581-91.
1999: A Ghavami; KL Stark; Mark Jareb; Sylvie Ramboz; L Ségu; René Hen
Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons.
Journal of cell science 1999;112 ( Pt 6)():967-76.
1999: Kimberly Scearce-Levie; S S Viswanathan; René Hen
Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT1B receptor.
Psychopharmacology 1999;141(2):154-61.
1998: Christian Waeber; Regis Grailhe; XJ Yu; René Hen; Michael A Moskowitz
Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation.
Annals of the New York Academy of Sciences 1998;861():85-90.
1998: KL Stark; Ronald Oosting; René Hen
Inducible knockout strategies to probe the functions of 5-HT receptors.
Annals of the New York Academy of Sciences 1998;861():57-66.
1998: Sylvie Ramboz; Ronald Oosting; D A Amara; Hank F Kung; Pierre Blier; Monica Mendelsohn; J John Mann; Dani Brunner; René Hen
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14476-81.
1998: KL Stark; Ronald Oosting; René Hen
Novel strategies to probe the functions of serotonin receptors.
Biological psychiatry 1998;44(3):163-8.
1998: J J Lucas; A Yamamoto; Kimberly Scearce-Levie; F Saudou; René Hen
Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(14):5537-44.
1998: Beatriz A Rocha; Kimberly Scearce-Levie; J J Lucas; Noboru Hiroi; N Castanon; John C Crabbe; Eric J Nestler; René Hen
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.
Nature 1998;393(6681):175-8.
1998: AC Trillat; Isabelle Malagié; Michel Bourin; Christian Jacquot; René Hen; Alain M Gardier
[Homozygote mice deficient in serotonin 5-HT1B receptor and antidepressant effect of selective serotonin reuptake inhibitors].
Comptes rendus des séances de la Société de biologie et de ses filiales 1998;192(6):1139-47.
1997: D Brunner; René Hen
Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice.
Annals of the New York Academy of Sciences 1997;836():81-105.
1997: A Ghavami; Mirko Baruscotti; Richard B Robinson; René Hen
Adenovirus-mediated expression of 5-HT1B receptors in cardiac ventricle myocytes; coupling to inwardly rectifying K+ channels.
European journal of pharmacology 1997;340(2-3):259-66.
1997: AC Trillat; Isabelle Malagié; K Scearce; D Pons; M C Anmella; Christian Jacquot; René Hen; Alain M Gardier
Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies.
Journal of neurochemistry 1997;69(5):2019-25.
1997: Beatriz A Rocha; Robert Ator; M W Emmett-Oglesby; René Hen
Intravenous cocaine self-administration in mice lacking 5-HT1B receptors.
Pharmacology, biochemistry, and behavior 1997;57(3):407-12.
1997: J J Lucas; L Segu; René Hen
5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935.
Molecular pharmacology 1997;51(5):755-63.