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Leonie Ashman

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Baratali Mashkani; Adam F Odell; Ellen M Byrnes; Renate Griffith; Leonie K Ashman
Expression of biologically active human colony stimulating factor-1 in Pichia pastoris.
Ben T Copeland; Matthew J Bowman; Leonie K Ashman
Genetic ablation of the tetraspanin CD151 reduces spontaneous metastatic spread of prostate cancer in the TRAMP model.
Leonie K Ashman; Renate Griffith
Therapeutic targeting of c-KIT in cancer.

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All Publications

2013: Baratali Mashkani; Adam F Odell; Ellen M Byrnes; Renate Griffith; Leonie K Ashman
Expression of biologically active human colony stimulating factor-1 in Pichia pastoris.
Protein expression and purification 2013;88(1):93-7.
2013: Ben T Copeland; Matthew J Bowman; Leonie K Ashman
Genetic ablation of the tetraspanin CD151 reduces spontaneous metastatic spread of prostate cancer in the TRAMP model.
Molecular cancer research : MCR 2013;11(1):95-105.
2013: Leonie K Ashman; Renate Griffith
Therapeutic targeting of c-KIT in cancer.
Expert opinion on investigational drugs 2013;22(1):103-15.
2011: Leonie K Ashman
Cell line models identify different sensitivity of mutant forms of c-KIT to kinase inhibitory drugs and predict the response of patients to therapy.
Molecular cancer therapeutics 2011;10(11):2032-3.
2011: R E Vilain; Allan D Spigelman; T Dudding; Claire Groombridge; Cliff Meldrum; S Ackland; Leonie K Ashman; S G Braye; R J Scott
Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?
Clinical genetics 2011;79(6):554-60.
2010: Baratali Mashkani; Renate Griffith; Leonie K Ashman
Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
Bioorganic & medicinal chemistry 2010;18(5):1789-97.
2009: Majd B Protty; Nicholas A Watkins; Dario Colombo; Steven G Thomas; Victoria L Heath; John M J Herbert; Roy Bicknell; Yotis A Senis; Leonie K Ashman; Fedor Berditchevski; Willem H Ouwehand; Steve P Watson; Michael G Tomlinson
Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains.
The Biochemical journal 2009;417(1):391-400.
2008: R Foster; E Byrnes; Cliff Meldrum; Renate Griffith; G Ross; E Upjohn; A Braue; R Scott; G Varigos; Petranel T Ferrao; Leonie K Ashman
Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT.
The British journal of dermatology 2008;159(5):1160-9.
2008: Rosa M Baleato; Petrina L Guthrie; Marie-Claire Gubler; Leonie K Ashman; Séverine Roselli
Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane.
The American journal of pathology 2008;173(4):927-37.
2008: Sean M Geary; Allison J Cowin; Ben Copeland; Rosa M Baleato; Kaoru Miyazaki; Leonie K Ashman
The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing.
Experimental cell research 2008;314(11-12):2165-75.
2007: Sonia M Young; Antony C Cambareri; Adam F Odell; Sean M Geary; Leonie K Ashman
Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor.
Cellular signalling 2007;19(12):2572-81.
2007: Kathryn G Roberts; Adam F Odell; Ellen M Byrnes; Rosa M Baleato; Renate Griffith; Alan Bruce Lyons; Leonie K Ashman
Resistance to c-KIT kinase inhibitors conferred by V654A mutation.
Molecular cancer therapeutics 2007;6(3):1159-66.
2006: R Griffith; M N Brown; Adam McCluskey; Leonie K Ashman
Small molecule inhibitors of protein kinases in cancer- how to overcome resistance.
Mini reviews in medicinal chemistry 2006;6(10):1101-10.
2006: Nicole E Winterwood; Afshin Varzavand; Marit N Meland; Leonie K Ashman; Christopher S Stipp
A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5.
Molecular biology of the cell 2006;17(6):2707-21.
2006: Sonia M Young; Antony C Cambareri; Leonie K Ashman
Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells.
Cellular signalling 2006;18(5):608-20.
2006: Allison J Cowin; Damian Adams; Sean M Geary; Mark D Wright; Jonathan C R Jones; Leonie K Ashman
Wound healing is defective in mice lacking tetraspanin CD151.
The Journal of investigative dermatology 2006;126(3):680-9.
2005: Carleen Cullinane; Donna S Dorow; Maya Kansara; Nelly Conus; David Binns; Rodney J Hicks; Leonie K Ashman; Grant A McArthur; David M Thomas
An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development.
Cancer research 2005;65(21):9633-6.
2005: Brett Nixon; Jonathan W Paul; Cassy M Spiller; Abigail G Attwell-Heap; Leonie K Ashman; R John Aitken
Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa.
Journal of cell science 2005;118(Pt 20):4865-77.
2005: Sabine Gesierich; Claudia Paret; Dagmar Hildebrand; Jürgen Weitz; Kaspar Zgraggen; Friedrich H Schmitz-Winnenthal; Vaclav Horejsi; Osamu Yoshie; Dorothee Herlyn; Leonie K Ashman; Margot Zöller
Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):2840-52.
2004: Jian Ang; Marijana Lijovic; Leonie K Ashman; Kathleen Kan; Albert G Frauman
CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: a new prognostic indicator?
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(11 Pt 1):1717-21.
2004: Lai-Man Lau; Janet L Wee; Mark D Wright; Gregory W Moseley; P Mark Hogarth; Leonie K Ashman; Denise E Jackson
The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function.
Blood 2004;104(8):2368-75.
2004: Rowan Foster; Renate Griffith; Petranel T Ferrao; Leonie K Ashman
Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase.
Journal of molecular graphics & modelling 2004;23(2):139-52.
2004: Mark D Wright; Sean M Geary; Stephen Fitter; Gregory W Moseley; Lai-Man Lau; Kuo-Ching Sheng; Vasso Apostolopoulos; Edouard G Stanley; Denise E Jackson; Leonie K Ashman
Characterization of mice lacking the tetraspanin superfamily member CD151.
Molecular and cellular biology 2004;24(13):5978-88.
2003: Nibedita Chattopadhyay; Zemin Wang; Leonie K Ashman; Susann M Brady-Kalnay; Jordan A Kreidberg
alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion.
The Journal of cell biology 2003;163(6):1351-62.
2003: Petranel T Ferrao; Michelle J Frost; Shoo-Peng Siah; Leonie K Ashman
Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro.
Blood 2003;102(13):4499-503.
2003: Le M Thai; Leonie K Ashman; Stacey N Harbour; P Mark Hogarth; Denise E Jackson
Physical proximity and functional interplay of PECAM-1 with the Fc receptor Fc gamma RIIa on the platelet plasma membrane.
Blood 2003;102(10):3637-45.
2003: Petranel T Ferrao; Thomas J Gonda; Leonie K Ashman
Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver.
Leukemia research 2003;27(6):547-55.
2003: Olexandr Voytyuk; Johan Lennartsson; Akira Mogi; Georgina Caruana; Sara Courtneidge; Leonie K Ashman; Lars Rönnstrand
Src family kinases are involved in the differential signaling from two splice forms of c-Kit.
The Journal of biological chemistry 2003;278(11):9159-66.
2003: L Bik To; John Bashford; Simon Durrant; J MacMillan; Anthony P Schwarer; H M Prince; John Gibson; I Lewis; BW Swart; J Marty; Trevor Rawling; Leonie K Ashman; S Charles; B Cohen
Successful mobilization of peripheral blood stem cells after addition of ancestim (stem cell factor) in patients who had failed a prior mobilization with filgrastim (granulocyte colony-stimulating factor) alone or with chemotherapy plus filgrastim.
Bone marrow transplantation 2003;31(5):371-8.
2002: Michelle J Frost; Petranel T Ferrao; Timothy P Hughes; Leonie K Ashman
Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.
Molecular cancer therapeutics 2002;1(12):1115-24.
2002: Jonathan A Fletcher; Christopher D M Fletcher; Brian P Rubin; Leonie K Ashman; Christopher L Corless; Michael C Heinrich
KIT gene mutations in gastrointestinal stromal tumors: more complex than previously recognized?
The American journal of pathology 2002;161(2):737-8; author reply 738-9.
2002: Leonie K Ashman
CD151.
Journal of biological regulators and homeostatic agents 2002;16(3):223-6.
2001: Fedor Berditchevski; Elizabeth Gilbert; Mark R Griffiths; S Fitter; Leonie K Ashman; S J Jenner
Analysis of the CD151-alpha3beta1 integrin and CD151-tetraspanin interactions by mutagenesis.
The Journal of biological chemistry 2001;276(44):41165-74.
2001: Sean M Geary; Antony C Cambareri; Paul Sincock; Stephen Fitter; Leonie K Ashman
Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies.
Tissue antigens 2001;58(3):141-53.
2001: R Chian; S Young; A Danilkovitch-Miagkova; L Rönnstrand; E Leonard; Petranel T Ferrao; Leonie K Ashman; D Linnekin
Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant.
Blood 2001;98(5):1365-73.
2001: Petranel T Ferrao; Paul Sincock; S Cole; Leonie K Ashman
Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia.
Leukemia research 2001;25(5):395-405.
2000: Leonie K Ashman; Petranel T Ferrao; S R Cole; Antony C Cambareri
Effects of mutant c-kit in early myeloid cells.
Leukemia & lymphoma 2000;37(1-2):233-43.
1999: Leonie K Ashman
The biology of stem cell factor and its receptor C-kit.
The international journal of biochemistry & cell biology 1999;31(10):1037-51.
1999: Georgina Caruana; Antony C Cambareri; Leonie K Ashman
Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts.
Oncogene 1999;18(40):5573-81.
1999: Leonie K Ashman; Petranel T Ferrao; S R Cole; Antony C Cambareri
Effects of mutant c-Kit in early myeloid cells.
Leukemia & lymphoma 1999;34(5-6):451-61.
1999: Mark A Gibson; David Leavesley; Leonie K Ashman
Microfibril-associated glycoprotein-2 specifically interacts with a range of bovine and human cell types via alphaVbeta3 integrin.
The Journal of biological chemistry 1999;274(19):13060-5.
1999: Paul Sincock; Stephen Fitter; Robert Parton; M C Berndt; J R Gamble; Leonie K Ashman
PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.
Journal of cell science 1999;112 ( Pt 6)():833-44.
1999: Stephen Fitter; Paul Sincock; Corina Jolliffe; Leonie K Ashman
Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion.
The Biochemical journal 1999;338 ( Pt 1)():61-70.
1998: Stephen Fitter; Michael F Seldin; Leonie K Ashman
Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms.
Biochimica et biophysica acta 1998;1398(1):75-85.
1998: Georgina Caruana; Antony C Cambareri; Thomas J Gonda; Leonie K Ashman
Transformation of NIH3T3 fibroblasts by the c-Kit receptor tyrosine kinase: effect of receptor density and ligand-requirement.
Oncogene 1998;16(2):179-90.
1997: Petranel T Ferrao; Thomas J Gonda; Leonie K Ashman
Expression of constitutively activated human c-Kit in Myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity.
Blood 1997;90(11):4539-52.
1997: Paul Sincock; Leonie K Ashman
Expression of c-Kit and functional drug efflux are correlated in de novo acute myeloid leukaemia.
Leukemia 1997;11(11):1850-7.
1997: G J Atkins; M Qiao; D R Coombe; E J Gowans; Leonie K Ashman
Hepatitis B virus binding to leucocyte plasma membranes utilizes a different region of the preS1 domain to the hepatocyte receptor binding site and does not require receptors for opsonins.
Immunology and cell biology 1997;75(3):259-66.
1997: Paul Sincock; Graham Mayrhofer; Leonie K Ashman
Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(4):515-25.
1997: Andrew C W Zannettino; G W Aylett; David Leavesley; T Pietsch; D G Chang; Paul J Simmons; Leonie K Ashman
Specificity and functional effects of antibodies to human stem cell factor.
Growth factors (Chur, Switzerland) 1997;14(1):67-79.
1996: S R Cole; G W Aylett; N L Harvey; Antony C Cambareri; Leonie K Ashman
Increased expression of c-Kit or its ligand Steel Factor is not a common feature of adult acute myeloid leukaemia.
Leukemia 1996;10(2):288-96.
1996: Andrew C W Zannettino; J R Rayner; Leonie K Ashman; Thomas J Gonda; Paul J Simmons
A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):611-20.
1995: Petranel T Ferrao; E M Macmillan; Leonie K Ashman; Thomas J Gonda
Enforced expression of full length c-Myb leads to density-dependent transformation of murine haemopoietic cells.
Oncogene 1995;11(8):1631-8.
1995: Stephen Fitter; T J Tetaz; M C Berndt; Leonie K Ashman
Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.
Blood 1995;86(4):1348-55.
1995: J J Roberts; S E Rodgers; J Drury; Leonie K Ashman; John V Lloyd
Platelet activation induced by a murine monoclonal antibody directed against a novel tetra-span antigen.
British journal of haematology 1995;89(4):853-60.
1994: L Bik To; David N Haylock; T Dowse; Paul J Simmons; S Trimboli; Leonie K Ashman; CA Juttner
A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells.
Blood 1994;84(9):2930-9.
1994: Leonie K Ashman; H J Bühring; G W Aylett; V C Broudy; C Müller
Epitope mapping and functional studies with three monoclonal antibodies to the c-kit receptor tyrosine kinase, YB5.B8, 17F11, and SR-1.
Journal of cellular physiology 1994;158(3):545-54.
1994: Paul J Simmons; G W Aylett; Silvana Niutta; L Bik To; CA Juttner; Leonie K Ashman
c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture.
Experimental hematology 1994;22(2):157-65.
1994: Paul J Simmons; David Leavesley; J P Levesque; B W Swart; David N Haylock; L Bik To; Leonie K Ashman; CA Juttner
The mobilization of primitive hemopoietic progenitors into the peripheral blood.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():187-201; discussion 201-2.
1993: G Caruana; Leonie K Ashman; J Fujita; T J Gonda
Responses of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SLF).
Experimental hematology 1993;21(6):761-8.
1991: Leonie K Ashman; G W Aylett
Expression of CD31 epitopes on human lymphocytes: CD31 monoclonal antibodies differentiate between naive (CD45RA+) and memory (CD45RA-) CD4-positive T cells.
Tissue antigens 1991;38(5):208-12.
1991: Leonie K Ashman; G W Aylett; Antony C Cambareri; S R Cole
Different epitopes of the CD31 antigen identified by monoclonal antibodies: cell type-specific patterns of expression.
Tissue antigens 1991;38(5):199-207.
1991: Leonie K Ashman; G W Aylett; P A Mehrabani; Linda Bendall; Silvana Niutta; Antony C Cambareri; S R Cole; M C Berndt
The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen.
British journal of haematology 1991;79(2):263-70.
1991: Leonie K Ashman; Antony C Cambareri; L B To; R J Levinsky; C A Juttner
Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow.
Blood 1991;78(1):30-7.
1990: Leonie K Ashman; Antony C Cambareri; J M Eglinton
A monoclonal antibody that inhibits the action of GM-CSF on normal but not leukaemic progenitors.
Leukemia research 1990;14(7):637-44.
1989: S R Cole; G W Kriek; R M Hope; Leonie K Ashman
Transfection of genes for human cell surface antigens identified by monoclonal antibodies.
Immunology and cell biology 1989;67 ( Pt 6)():377-84.
1988: A B Lyons; S J Cooper; S R Cole; Leonie K Ashman
Human myeloid differentiation antigens identified by monoclonal antibodies to the myelomonocytic leukemia cell line RC-2A.
Pathology 1988;20(2):137-46.
1988: Leonie K Ashman; M M Roberts; S J Gadd; S J Cooper; C A Juttner
Expression of a 150-kD cell surface antigen identified by monoclonal antibody YB5.B8 is associated with poor prognosis in acute non-lymphoblastic leukaemia.
Leukemia research 1988;12(11-12):923-8.
1988: Antony C Cambareri; Leonie K Ashman; S R Cole; A B Lyons
A monoclonal antibody to a human mast cell/myeloid leukaemia-specific antigen binds to normal haemopoietic progenitor cells and inhibits colony formation in vitro.
Leukemia research 1988;12(11-12):929-39.
1987: Leonie K Ashman
The immunogenicity of tumour cells.
Immunology and cell biology 1987;65 ( Pt 4)():271-7.
1987: S R Cole; Leonie K Ashman; Peter L Ey
Biotinylation: an alternative to radioiodination for the identification of cell surface antigens in immunoprecipitates.
Molecular immunology 1987;24(7):699-705.
1987: G Mayrhofer; S J Gadd; L D Spargo; Leonie K Ashman
Specificity of a mouse monoclonal antibody raised against acute myeloid leukaemia cells for mast cells in human mucosal and connective tissues.
Immunology and cell biology 1987;65 ( Pt 3)():241-50.
1987: Deborah L White; Leonie K Ashman; G W Dart; Heddy Zola; I R Toogood; R J Kimber
The expression of mature myeloid cell differentiation markers in acute leukemia.
Pathology 1987;19(2):137-42.
1987: A B Lyons; Leonie K Ashman
Studies on the differentiation of the human myelomonocytic cell line RC-2A in response to lymphocyte-derived factors.
Leukemia research 1987;11(9):797-805.
1987: Leonie K Ashman; D White; Heddy Zola; G W Dart
Expression of the non-T ALL-associated p24 antigen on leukaemic blasts from patients with ANLL.
Leukemia research 1987;11(1):97-101.
1985: S J Gadd; Leonie K Ashman
A murine monoclonal antibody specific for a cell-surface antigen expressed by a subgroup of human myeloid leukaemias.
Leukemia research 1985;9(11):1329-36.
1983: S J Gadd; Leonie K Ashman
Binding of mouse monoclonal antibodies to human leukaemic cells via the Fc receptor: a possible source of 'false positive' reactions in specificity screening.
Clinical and experimental immunology 1983;54(3):811-8.