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Boon Chin Heng

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Zigang Ge; Boon Chin Heng; Chao Li; Guoxin Cao; Zheng Yang
Functional biomaterials for cartilage regeneration.
Boon Chin Heng; Jian Li; William R Birch; Allen Kuan-Liang Chen; Simon Cool; Shaul Reuveny; Steve Kah-Weng Oh
Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces.
Guo Qing Tong; Xun Wu; Jun Qiang Zhang; Shan Ren Cao; Ji Cui; Boon Chin Heng; Xiu Feng Ling
Clinical outcome of fresh and vitrified-warmed blastocyst and cleavage-stage embryo transfers in ethnic Chinese ART patients.

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2012: Zigang Ge; Boon Chin Heng; Chao Li; Guoxin Cao; Zheng Yang
Functional biomaterials for cartilage regeneration.
Journal of biomedical materials research. Part A 2012;100(9):2526-36.
2012: Boon Chin Heng; Jian Li; William R Birch; Allen Kuan-Liang Chen; Simon Cool; Shaul Reuveny; Steve Kah-Weng Oh
Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces.
Stem cells and development 2012;21(10):1701-15.
2012: Guo Qing Tong; Xun Wu; Jun Qiang Zhang; Shan Ren Cao; Ji Cui; Boon Chin Heng; Xiu Feng Ling
Clinical outcome of fresh and vitrified-warmed blastocyst and cleavage-stage embryo transfers in ethnic Chinese ART patients.
Journal of ovarian research 2012;5(1):27.
2012: Weiliang Shen; Zi Yin; Jialin Chen; Weishan Chen; Xiao Chen; Boon Chin Heng; Huanhuan Liu; Hong Wei Ouyang
Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair.
Cell transplantation 2012;21(5):943-58.
2011: Boon Chin Heng; Nurulain Khamis; Aarti Assodani; Kee Woei Ng; Christiane Ruedl; Eng Chok Tan; Sijing Xiong; Xinxin Zhao; Joachim Say Chye Loo
Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles.
Archives of toxicology 2011;85(12):1517-28.
2011: Kee Woei Ng; Magdiel I Setyawati; Eng Chok Tan; Sijing Xiong; Xinxin Zhao; Wanru Fang; Boon Chin Heng; Stella P K Khoo; David T Leong; Joachim Say Chye Loo
The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles.
Biomaterials 2011;32(32):8218-25.
2011: Xinxin Zhao; Boon Chin Heng; Sijing Xiong; Jun Guo; Timothy Thatt-Yang Tan; Freddy Boey; Kee Woei Ng; Joachim Say Chye Loo
In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas.
Nanotoxicology 2011;5(2):182-94.
2011: Boon Chin Heng; Xinxin Zhao; Sijing Xiong; Kee Woei Ng; Freddy Boey; Joachim Say Chye Loo
Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format.
Archives of toxicology 2011;85(6):695-704.
2011: Sijing Xiong; Xinxin Zhao; Boon Chin Heng; Kee Woei Ng; Joachim Say Chye Loo
Cellular uptake of Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method.
Biotechnology journal 2011;6(5):501-8.
2011: Boon Chin Heng; Paula Porto Bezerra; Peter Rainer Preiser; S K Alex Law; Yun Xia; Freddy Boey; Subbu S Venkatraman
Effect of cell-seeding density on the proliferation and gene expression profile of human umbilical vein endothelial cells within ex vivo culture.
Cytotherapy 2011;13(5):606-17.
2011: Dandan Zhu; Juanjuan Zhang; Shanren Cao; Junqiang Zhang; Boon Chin Heng; Meiling Huang; Xiufeng Ling; Tao Duan; Guo Qing Tong
Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles--time for a new embryo transfer strategy?
Fertility and sterility 2011;95(5):1691-5.
2011: Yun Xia; Melissa Prawirasatya; Boon Chin Heng; Freddy Boey; Subbu S Venkatraman
Seeding density matters: extensive intercellular contact masks the surface dependence of endothelial cell-biomaterial interactions.
Journal of materials science. Materials in medicine 2011;22(2):389-96.
2010: Jia Lin Chen; Zi Yin; Wei Liang Shen; Xiao Chen; Boon Chin Heng; Xiao Hui Zou; Hong Wei Ouyang
Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles.
Biomaterials 2010;31(36):9438-51.
2010: Weiliang Shen; Xiao Chen; Jialin Chen; Zi Yin; Boon Chin Heng; Weishan Chen; Hong Wei Ouyang
The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration.
Biomaterials 2010;31(28):7239-49.
2010: Boon Chin Heng; Gautom Kumar Das; Xinxin Zhao; Lwin-Lwin Ma; Timothy Thatt-Yang Tan; Kee Woei Ng; Joachim Say Chye Loo
Comparative cytotoxicity evaluation of lanthanide nanomaterials on mouse and human cell lines with metabolic and DNA-quantification assays.
Biointerphases 2010;5(3):FA88-97.
2010: Boon Chin Heng; Paula Porto Bezerra; Qing Rui Meng; Desmond Wai-Loon Chin; KOH LI BUAY; Hai Li; Hua Zhang; Peter Rainer Preiser; Freddy Boey; Subbu S Venkatraman
Adhesion, proliferation, and gene expression profile of human umbilical vein endothelial cells cultured on bilayered polyelectrolyte coatings composed of glycosaminoglycans.
Biointerphases 2010;5(3):FA53-62.
2010: Boon Chin Heng; Xinxin Zhao; Sijing Xiong; Kee Woei Ng; Freddy Boey; Joachim Say Chye Loo
Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2010;48(6):1762-6.
2010: Gautom Kumar Das; Boon Chin Heng; Sui-Choon Ng; Tim White; Joachim Say Chye Loo; Loyola D'Silva; Parasuraman Padmanabhan; Kishore K Bhakoo; Subramanian Tamil Selvan; Timothy Thatt Yang Tan
Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging.
Langmuir : the ACS journal of surfaces and colloids 2010;26(11):8959-65.
2010: Jun Qiang Zhang; Xiu Ling Li; Yuzhu Peng; Xirong Guo; Boon Chin Heng; Guo Qing Tong
Reduction in exposure of human embryos outside the incubator enhances embryo quality and blastulation rate.
Reproductive biomedicine online 2010;20(4):510-5.
2010: Abdul Jalil Rufaihah; Husnain Khawaja Haider; Boon Chin Heng; Lei Ye; Ru San Tan; Wei Seong Toh; Xian Feng Tian; Eugene Kwang-Wei Sim; tong cao
Therapeutic angiogenesis by transplantation of human embryonic stem cell-derived CD133+ endothelial progenitor cells for cardiac repair.
Regenerative medicine 2010;5(2):231-44.
2010: Boon Chin Heng; Mark Richards; Zigang Ge; Yimin Shu
Induced adult stem (iAS) cells and induced transit amplifying progenitor (iTAP) cells-a possible alternative to induced pluripotent stem (iPS) cells?
Journal of tissue engineering and regenerative medicine 2010;4(2):159-62.
2010: Shi-you Zhou; Zhao-lian Xie; Ou Xiao; Xiao-ru Yang; Boon Chin Heng; Yasufumi Sato
Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1.
Molecular vision 2010;16():1389-98.
2009: Xiu Feng Ling; Jun Qiang Zhang; Shan Ren Cao; Jie Chen; Yuzhu Peng; Xirong Guo; Boon Chin Heng; Guo Qing Tong; Xinru Wang
Effect of cryotop vitrification on preimplantation developmental competence of murine morula and blastocyst stage embryos.
Reproductive biomedicine online 2009;19(5):708-13.
2009: Junqiang Zhang; Ji Cui; Xiufeng Ling; Xiuling Li; Yuzhu Peng; Xirong Guo; Boon Chin Heng; Guo Qing Tong
Vitrification of mouse embryos at 2-cell, 4-cell and 8-cell stages by cryotop method.
Journal of assisted reproduction and genetics 2009;26(11-12):621-8.
2009: Boon Chin Heng
Effect of Rho-associated kinase (ROCK) inhibitor Y-27632 on the post-thaw viability of cryopreserved human bone marrow-derived mesenchymal stem cells.
Tissue & cell 2009;41(5):376-80.
2009: Saji George; Boon Chin Heng; Kumar Jayaseelan Vinoth; Anil kishen; tong cao
Comparison of the response of human embryonic stem cells and their differentiated progenies to oxidative stress.
Photomedicine and laser surgery 2009;27(4):669-74.
2009: Boon Chin Heng; Mark Richards; Yimin Shu; philip Gribbon
Induced pluripotent stem cells: a new tool for toxicology screening?
Archives of toxicology 2009;83(7):641-4.
2009: Zigang Ge; Xianfeng Tian; Boon Chin Heng; Victor Fan; Jin-Fei Yeo; tong cao
Histological evaluation of osteogenesis of 3D-printed poly-lactic-co-glycolic acid (PLGA) scaffolds in a rabbit model.
Biomedical materials (Bristol, England) 2009;4(2):021001.
2009: Boon Chin Heng; Mark Richards; Tong Cao
Are stem cells inherently more prone to cryopreservation-induced apoptosis compared to ordinary somatic cells?
Human reproduction (Oxford, England) 2009;24(2):492; author reply 492-3.
2009: Boon Chin Heng
Should patients diagnosed with polycystic ovary syndrome (PCOS) participate in compensated egg sharing in return for subsidized fertility treatment?
Human reproduction and genetic ethics 2009;15(1):4-6.
2009: Boon Chin Heng
Stringent regulation of oocyte donation in China.
Human reproduction (Oxford, England) 2009;24(1):14-6.
2008: Boon Chin Heng; philip Gribbon; Anthony J Day; Timothy E Hardingham
Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH.
The Journal of biological chemistry 2008;283(47):32294-301.
2008: Kumar Jayaseelan Vinoth; Boon Chin Heng; Anuradha Poonepalli; Birendranath Banerjee; Lakshmidevi Balakrishnan; Kai Lu; M Prakash Hande; tong cao
Human embryonic stem cells may display higher resistance to genotoxic stress as compared to primary explanted somatic cells.
Stem cells and development 2008;17(3):599-607.
2008: Boon Chin Heng; Wei Seong Toh; Barry Peter Pereira; Bee-Leng Tan; Xin Fu; Hua Liu; Kai Lu; Jin-Fei Yeo; tong cao
An autologous cell lysate extract from human embryonic stem cell (hESC) derived osteoblasts can enhance osteogenesis of hESC.
Tissue & cell 2008;40(3):219-28.
2008: Boon Chin Heng
Egg sharing in return for subsidized fertility treatment--ethical challenges and pitfalls.
Journal of assisted reproduction and genetics 2008;25(4):159-61.
2008: tong cao; Kai Lu; Xin Fu; Boon Chin Heng
Differentiated fibroblastic progenies of human embryonic stem cells for toxicology screening.
Cloning and stem cells 2008;10(1):1-10.
2008: Boon Chin Heng; Mark Richards
Induced Pluripotent Stem Cells (iPSC)--can direct delivery of transcription factors into the cytosol overcome the perils of permanent genetic modification?
Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy 2008;17(5):326-7; author reply 328.
2008: X-F Tian; Boon Chin Heng; Zigang Ge; K Lu; Abdul Jalil Rufaihah; V T-W Fan; Jin-Fei Yeo; tong cao
Comparison of osteogenesis of human embryonic stem cells within 2D and 3D culture systems.
Scandinavian journal of clinical and laboratory investigation 2008;68(1):58-67.
2007: Boon Chin Heng
Discarded human spermatozoa, eggs and embryos for personnel training and practice in assisted reproduction.
Reproductive biomedicine online 2007;15 Suppl 2():5-6.
2007: Boon Chin Heng
Growing surplus of frozen embryos in China offers opportunities for the development of human embryonic stem cell banking.
Regenerative medicine 2007;2(6):873-4.
2007: Boon Chin Heng; Marie-Veronique Clement; tong cao
Caspase inhibitor Z-VAD-FMK enhances the freeze-thaw survival rate of human embryonic stem cells.
Bioscience reports 2007;27(4-5):257-64.
2007: Boon Chin Heng
Proposed ethical guidelines and legislative framework for permitting gestational surrogacy in Singapore.
Reproductive biomedicine online 2007;15 Suppl 1():7-11.
2007: Guo Qing Tong; Boon Chin Heng; Soon Chye Ng
Cumulus-specific genes are transcriptionally silent following somatic cell nuclear transfer in a mouse model.
Journal of Zhejiang University. Science. B 2007;8(8):533-9.
2007: Boon Chin Heng
Regulatory safeguards needed for the travelling foreign egg donor.
Human reproduction (Oxford, England) 2007;22(8):2350-2.
2007: Boon Chin Heng
Independent counselling on embryo donation for infertility patients.
Human reproduction (Oxford, England) 2007;22(8):2346-8.
2007: Boon Chin Heng
Factors influencing the reimbursement rate of egg donation within a competitive free-market system.
Reproductive biomedicine online 2007;15(1):16-8.
2007: Boon Chin Heng
Reluctance of medical professionals in adopting natural-cycle and minimal ovarian stimulation protocols in human clinical assisted reproduction.
Reproductive biomedicine online 2007;15(1):9-11.
2007: Boon Chin Heng
Disparity in medical fees for donor- and self-freeze/thaw embryo transfer cycle: opportunistic profiteering by medical professionals and health institutions?
Human fertility (Cambridge, England) 2007;10(2):129-30.
2007: Abdul Jalil Rufaihah; Husnain Khawaja Haider; Boon Chin Heng; Lei Ye; Wei Seong Toh; Xian Feng Tian; Kai Lu; Eugene K W Sim; tong cao
Directing endothelial differentiation of human embryonic stem cells via transduction with an adenoviral vector expressing the VEGF(165) gene.
The journal of gene medicine 2007;9(6):452-61.
2007: Boon Chin Heng; Xiao Zhang
Perspectives on compensated egg-sharing in the People's Republic of China.
Reproductive biomedicine online 2007;14(5):664-5.
2007: Boon Chin Heng; Hua Liu; Zigang Ge; tong cao
Mechanical dissociation of human embryonic stem cell colonies by manual scraping after collagenase treatment is much more detrimental to cellular viability than is trypsinization with gentle pipetting.
Biotechnology and applied biochemistry 2007;47(Pt 1):33-7.
2007: Chao Peng Ye; Boon Chin Heng; Hua Liu; Wei Seong Toh; tong cao
Culture media conditioned by heat-shocked osteoblasts enhances the osteogenesis of bone marrow-derived mesenchymal stromal cells.
Cell biochemistry and function 2007;25(3):267-76.
2007: Boon Chin Heng
Legal and ethical issues in the international transaction of donor sperm and eggs.
Journal of assisted reproduction and genetics 2007;24(4):107-9.
2007: Boon Chin Heng
Disparity in medical fees for donor and self freeze-thaw embryo transfer cycle--a covert form of embryo commercialization?
Developing world bioethics 2007;7(1):49-50.
2007: Wei Seong Toh; Zheng Yang; Hua Liu; Boon Chin Heng; Eng Hin Lee; tong cao
Effects of culture conditions and bone morphogenetic protein 2 on extent of chondrogenesis from human embryonic stem cells.
Stem cells (Dayton, Ohio) 2007;25(4):950-60.
2007: Boon Chin Heng
Is it ethically justifiable to cryopreserve oocytes and ovarian tissues of healthy women not facing premature ovarian failure, but seeking to extend their biological clocks?
Human fertility (Cambridge, England) 2007;10(1):49-50.
2007: Boon Chin Heng
Oocyte cryopreservation as alternative to embryo cryopreservation - some pertinent ethical concerns.
Reproductive biomedicine online 2007;14(3):402-3.
2007: Wei Seong Toh; Zheng Yang; Boon Chin Heng; tong cao
Differentiation of human embryonic stem cells toward the chondrogenic lineage.
Methods in molecular biology (Clifton, N.J.) 2007;407():333-49.
2007: Boon Chin Heng
Can the difference in medical fees for self and donor freeze-thaw embryo transfer cycle, be in fact a cover-up for the sale of donated human embryos?
Philosophy, ethics, and humanities in medicine : PEHM 2007;2():3.
2007: Boon Chin Heng
Should embryo donation be actively encouraged and advocated for couples with only one infertile partner?
Journal of assisted reproduction and genetics 2007;24(1):57-8.
2007: Boon Chin Heng
Should fertility specialists refer local patients abroad for shared or commercialized oocyte donation?
Fertility and sterility 2007;87(1):6-7.
2006: Boon Chin Heng
Ethical issues in transnational "mail order" oocyte donation.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2006;95(3):302-4.
2006: Boon Chin Heng; Chao Peng Ye; Hua Liu; Wei Seong Toh; Abdul Jalil Rufaihah; tong cao
Kinetics of cell death of frozen-thawed human embryonic stem cell colonies is reversibly slowed down by exposure to low temperature.
Zygote (Cambridge, England) 2006;14(4):341-8.
2006: Guo Qing Tong; Boon Chin Heng; Soon Chye Ng
Exposure of mouse cumulus cell nuclei to porcine ooplasmic extract eliminates TATA box protein binding to chromatin, but has no effect on DNA methylation.
Journal of assisted reproduction and genetics 2006;23(11-12):413-9.
2006: Boon Chin Heng; Toan-Thang Phan; Hua Liu; Hong Wei Ouyang; Tong Cao
Can the therapeutic advantages of allogenic umbilical cord blood-derived stem cells and autologous bone marrow-derived mesenchymal stem cells be combined and synergized?
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2006;52(6):611-3.
2006: Boon Chin Heng
The advent of international 'mail-order' egg donation.
BJOG : an international journal of obstetrics and gynaecology 2006;113(11):1225-7.
2006: Boon Chin Heng
Advanced maternal age as an indication for preimplantation genetic diagnosis (PGD)--the need for more judicious application in clinically assisted reproduction.
Prenatal diagnosis 2006;26(11):1051-3.
2006: Boon Chin Heng
Preimplantation genetic diagnosis (PGD) should be judiciously indicated for male-factor subfertility and ICSI patients.
Journal of andrology 2006;27(6):708-9.
2006: Boon Chin Heng; Tong Cao
Refund fertility-treatment costs for donated embryos.
Nature 2006;443(7107):26.
2006: Boon Chin Heng
Donation of surplus frozen embryos for stem cell research or fertility treatment-should medical professionals and healthcare institutions be allowed to exercise undue influence on the informed decision of their former patients?
Journal of assisted reproduction and genetics 2006;23(9-10):381-2.
2006: Guo Qing Tong; Boon Chin Heng; Lay-Geok Tan; Soon Chye Ng
Aberrant profile of gene expression in cloned mouse embryos derived from donor cumulus nuclei.
Cell and tissue research 2006;325(2):231-43.
2006: Hong Wei Ouyang; tong cao; Xiao Hui Zou; Boon Chin Heng; Ling Ling Wang; Xing Hui Song; He-feng Huang
Mesenchymal stem cell sheets revitalize nonviable dense grafts: implications for repair of large-bone and tendon defects.
Transplantation 2006;82(2):170-4.
2006: Boon Chin Heng
Regulated family balancing by equalizing the sex-ratio of gender-selected births.
Journal of assisted reproduction and genetics 2006;23(7-8):319-20.
2006: Zigang Ge; Yang Hu; Boon Chin Heng; Zheng Yang; Hongwei Ouyang; Eng Hin Lee; tong cao
Osteoarthritis and therapy.
Arthritis and rheumatism 2006;55(3):493-500.
2006: Boon Chin Heng
Delayed motherhood through oocyte and ovarian tissue cryopreservation - a perspective from Singapore.
Reproductive biomedicine online 2006;12(6):660-2.
2006: Boon Chin Heng; Chao Peng Ye; Hua Liu; Wei Seong Toh; Abdul Jalil Rufaihah; Zheng Yang; Boon-Huat Bay; Zigang Ge; Hong Wei Ouyang; Eng Hin Lee; tong cao
Loss of viability during freeze-thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis.
Journal of biomedical science 2006;13(3):433-45.
2006: Boon Chin Heng; Guo Qing Tong
Mirror exchange of donor gametes should also accommodate scientific research.
Human reproduction (Oxford, England) 2006;21(4):1100; author reply 1101.
2006: Boon Chin Heng; Hua Liu; Abdul Jalil Rufaihah; tong cao
Human embryonic stem cell (hES) colonies display a higher degree of spontaneous differentiation when passaged at lower densities.
In vitro cellular & developmental biology. Animal 2006;42(3-4):54-7.
2006: Boon Chin Heng; Tong Cao
Milieu-based versus gene-modulatory strategies for directing stem cell differentiation--A major issue of contention in transplantation medicine.
In vitro cellular & developmental biology. Animal 2006;42(3-4):51-3.
2006: Boon Chin Heng
Gender selection of embryos after PGD for other independent medical reasons--a viewpoint from Singapore.
Reproductive biomedicine online 2006;12(3):392-3.
2006: Boon Chin Heng
Alternative solutions to the current situation of oocyte donation in Singapore.
Reproductive biomedicine online 2006;12(3):286-91.
2006: Boon Chin Heng
Advances in oocyte cryopreservation technology will eventually blur the ethical and moral boundaries between compensated egg sharing and commercialized oocyte donation.
Reproductive biomedicine online 2006;12(3):280-1.
2006: Hua Liu; David M Kemeny; Boon Chin Heng; Hong Wei Ouyang; Alirio J Melendez; tong cao
The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2864-71.
2006: Boon Chin Heng
'Reproductive tourism': should locally registered fertility doctors be held accountable for channelling patients to foreign medical establishments?
Human reproduction (Oxford, England) 2006;21(3):840-2.
2006: Boon Chin Heng; Kumar Jayaseelan Vinoth; Hua Liu; M Prakash Hande; tong cao
Low temperature tolerance of human embryonic stem cells.
International journal of medical sciences 2006;3(4):124-9.
2006: Wei Seong Toh; Zheng Yang; Boon Chin Heng; tong cao
New perspectives in chondrogenic differentiation of stem cells for cartilage repair.
TheScientificWorldJournal 2006;6():361-4.
2006: Boon Chin Heng
Donation of surplus cryopreserved oocytes and ovarian tissue sections--should the medical institution involved in cryopreservation and storage possess exclusive rights of distribution to prospective recipients?
Medical hypotheses 2006;67(3):674-5.
2006: Boon Chin Heng; Tong Cao; Miodrag Stojkovic; Gábor Vajta
Mammalian oocyte polarity can be exploited for the automation of somatic cell nuclear transfer--in the development of a 'cloning biochip'.
Medical hypotheses 2006;67(2):420-1.
2006: Boon Chin Heng; Guo Qing Tong
Reciprocal oocyte sharing in return for altruistic sperm donation to fulfill the demands of clinical assisted reproduction and somatic cell nuclear transfer (SCNT) research.
Medical hypotheses 2006;67(1):201-2.
2006: Boon Chin Heng
Is it ethically-justifiable for fertility doctors to refer or recommend local patients to foreign clinics for oocyte donation?
Medical hypotheses 2006;66(6):1255-6.
2006: Boon Chin Heng; Guo Qing Tong; Miodrag Stojkovic
The egg-sharing model for human therapeutic cloning research: managing donor selection criteria, the proportion of shared oocytes allocated to research, and amount of financial subsidy given to the donor.
Medical hypotheses 2006;66(5):1022-4.
2006: Boon Chin Heng
Donation of supernumerary oocytes for the derivation of nuclear transfer stem cells, in return for the promise of future therapeutic benefits: ethical and moral obligations of medical professionals to the patient.
Medical hypotheses 2006;66(4):860-1.
2006: Boon Chin Heng
Egg-sharing across international borders. This may ease the shortage of donor oocytes in more economically developed countries while making fertility treatment affordable to childless couples from poorer countries.
Medical hypotheses 2006;66(2):443.
2006: Boon Chin Heng
Handing out free travel and accommodation to oocyte donors in lieu of monetary payment: is this ethically justifiable?
Medical hypotheses 2006;66(1):212-3.
2005: Boon Chin Heng
International egg-sharing to provide donor oocytes for clinical assisted reproduction and derivation of nuclear transfer stem cells.
Reproductive biomedicine online 2005;11(6):676-8.
2005: Wei Seong Toh; Hua Liu; Boon Chin Heng; Abdul Jalil Rufaihah; Chao Peng Ye; tong cao
Combined effects of TGFbeta1 and BMP2 in serum-free chondrogenic differentiation of mesenchymal stem cells induced hyaline-like cartilage formation.
Growth factors (Chur, Switzerland) 2005;23(4):313-21.
2005: Boon Chin Heng
Ethical issues in paying for long-distance travel and accommodation expenses of oocyte donors.
Reproductive biomedicine online 2005;11(5):552-3.
2005: Boon Chin Heng
Egg-sharing in return for subsidized fertility treatment: a possible solution for therapeutic cloning?
Human reproduction (Oxford, England) 2005;20(11):3258.
2005: Boon Chin Heng; Ian K McNiece; Husnain Khawaja Haider; Roy Yorke Calne; tong cao
Possible advantages of stem cell transfusion into the peripheral circulation, as opposed to localized transplantation in situ.
Stem cells and development 2005;14(4):351-3.
2005: tong cao; Boon Chin Heng; Chao Peng Ye; Hua Liu; Wei Seong Toh; Paul Robson; Pin Li; Yun Han Hong; Lawrence W Stanton
Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures.
Tissue & cell 2005;37(4):325-34.
2005: Boon Chin Heng; Yun Han Hong; tong cao
Modulating gene expression in stem cells without recombinant DNA and permanent genetic modification.
Cell and tissue research 2005;321(2):147-50.
2005: Boon Chin Heng; tong cao; Husnain Khawaja Haider; Abdul Jalil Rufaihah; Eugene K W Sim
Utilizing stem cells for myocardial repair--to differentiate or not to differentiate prior to transplantation?
Scandinavian cardiovascular journal : SCJ 2005;39(3):131-4.
2005: Boon Chin Heng; Hanry Yu; Yijun Yin; Seng Gee Lim; tong cao
Factors influencing stem cell differentiation into the hepatic lineage in vitro.
Journal of gastroenterology and hepatology 2005;20(7):975-87.
2005: Boon Chin Heng; Tong Cao
Co-transplantation of autologous adult stem cells together with differentiated derivatives of human embryonic stem cells. A novel strategy to enhance the efficacy of autologous cell-transplantation therapy?
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2005;13(3):353-6.
2005: Boon Chin Heng; Husnain Khawaja Haider; Eugene K W Sim; tong cao; Guo Qing Tong; Soon Chye Ng
Reprogramming autologous skeletal myoblasts to express cardiomyogenic function. Challenges and possible approaches.
International journal of cardiology 2005;100(3):355-62.
2005: Boon Chin Heng; tong cao
Incorporating protein transduction domains (PTD) within recombinant 'fusion' transcription factors. A novel strategy for directing stem cell differentiation?
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2005;59(3):132-4.
2005: Boon Chin Heng; Lilia L Kuleshova; Soren Müller Bested; Hua Liu; tong cao
The cryopreservation of human embryonic stem cells.
Biotechnology and applied biochemistry 2005;41(Pt 2):97-104.
2005: Boon Chin Heng; Soren Müller Bested; Swee H Chan; tong cao
A proposed design for the cryopreservation of intact and adherent human embryonic stem cell colonies.
In vitro cellular & developmental biology. Animal 2005;41(3-4):77-9.
2005: tong cao; Tzuen Yih Saw; Boon Chin Heng; Hua Liu; Adrian U J Yap; Mah-Lee Ng
Comparison of different test models for the assessment of cytotoxicity of composite resins.
Journal of applied toxicology : JAT 2005;25(2):101-8.
2005: Boon Chin Heng; tong cao; Hua Liu; Abdul Jalil Rufaihah
Reduced mitotic activity at the periphery of human embryonic stem cell colonies cultured in vitro with mitotically-inactivated murine embryonic fibroblast feeder cells.
Cell biochemistry and function 2005;23(2):141-6.
2005: Boon Chin Heng; Husnain Khawaja Haider; Eugene K W Sim; tong cao; Guo Qing Tong; Soon Chye Ng
Comments about possible use of human embryonic stem cell-derived cardiomyocytes to direct autologous adult stem cells into the cardiomyogenic lineage.
Acta cardiologica 2005;60(1):7-12.
2005: Boon Chin Heng; tong cao; Soren Müller Bested; Guo Qing Tong; Soon Chye Ng
"Waste" follicular aspirate from fertility treatment--a potential source of human germline stem cells?
Stem cells and development 2005;14(1):11-4.
2005: Boon Chin Heng; Hua Liu; tong cao
Late-adhering human embryonic stem cell clumps during serial passage can yield morphologically 'normal-looking' colonies.
Annals of clinical and laboratory science 2005;35(4):459-62.
2005: Tong Cao; Boon Chin Heng
Differentiation therapy of cancer. Potential advantages over conventional therapeutic approaches targeting death of cancer/tumor cells.
Medical hypotheses 2005;65(6):1202-3.
2005: tong cao; Boon Chin Heng
Intracellular antibodies (intrabodies) versus RNA interference for therapeutic applications.
Annals of clinical and laboratory science 2005;35(3):227-9.
2005: Boon Chin Heng
Egg-sharing in return for subsidized fertility treatment--an ethically justifiable and practical solution to overcome the shortage of donor oocytes for therapeutic cloning.
Medical hypotheses 2005;65(5):999-1000.
2005: Tong Cao; Hua Liu; Boon Chin Heng
Combining RNA interference with PTD-fusion transcription factors: a novel integrated strategy for achieving trans-differentiation of adult stem cells?
Medical hypotheses 2005;65(5):992-3.
2005: Boon Chin Heng; Husnain Khawaja Haider; tong cao
Combining transfusion of stem/progenitor cells into the peripheral circulation with localized transplantation in situ at the site of tissue/organ damage: a possible strategy to optimize the efficacy of stem cell transplantation therapy.
Medical hypotheses 2005;65(3):494-7.
2005: Boon Chin Heng; Hua Liu; Tong Cao
Scaffold implants for the controlled release of heparan sulfate (HS) and other glycosaminoglycan (GAG) species: this could facilitate the homing of adult stem cells for tissue/organ regeneration.
Medical hypotheses 2005;65(2):414-5.
2005: Boon Chin Heng; Tong Cao
Could the transit-amplifying stage of stem cell differentiation be the most suited for transplantation purposes?
Medical hypotheses 2005;65(2):412-3.
2005: Boon Chin Heng; tong cao
Immunoliposome-mediated delivery of neomycin phosphotransferase for the lineage-specific selection of differentiated/committed stem cell progenies: potential advantages over transfection with marker genes, fluorescence-activated and magnetic affinity cell-sorting.
Medical hypotheses 2005;65(2):334-6.
2005: Boon Chin Heng; Tong Cao
Making cell-permeable recombinant telomerase (trans-telomerase) through fusion of its catalytic subunit (hTERT) with protein transduction domains (PTD): a possible strategy to overcome replicative senescence during ex vivo culture of primary explanted cells.
Medical hypotheses 2005;65(1):199-200.
2005: Boon Chin Heng; Hua Liu; Tong Cao
Potential benefits of co-transplanting autologous adult stem cells together with human embryonic stem cells or their differentiated derivatives.
Annals of clinical and laboratory science 2005;35(1):3-6.
2005: Boon Chin Heng; Hua Liu; Tong Cao
Can the high nuclear to cytoplasmic ratio of human embryonic stem cells make them more vulnerable to physical stress encountered with bulk-passage protocols?
Medical hypotheses 2005;64(6):1242-3.
2005: Boon Chin Heng; tong cao
Making cell-permeable antibodies (Transbody) through fusion of protein transduction domains (PTD) with single chain variable fragment (scFv) antibodies: potential advantages over antibodies expressed within the intracellular environment (Intrabody).
Medical hypotheses 2005;64(6):1105-8.
2005: Boon Chin Heng; Hua Liu; tong cao
Transplanted human embryonic stem cells as biological 'catalysts' for tissue repair and regeneration.
Medical hypotheses 2005;64(6):1085-8.
2005: Boon Chin Heng; David M Kemeny; Hua Liu; tong cao
Potential applications of intracellular antibodies (intrabodies) in stem cell therapeutics.
Journal of cellular and molecular medicine 2005;9(1):191-5.
2005: Boon Chin Heng; tong cao
Incorporating protein transduction domains (PTD) within intracellular proteins associated with the 'stemness' phenotype. Novel use of such recombinant 'fusion' proteins to overcome current limitations of applying autologous adult stem cells in regenerative medicine?
Medical hypotheses 2005;64(5):992-6.
2005: Boon Chin Heng; tong cao; Hua Liu; Toan-Thang Phan
Directing stem cells into the keratinocyte lineage in vitro.
Experimental dermatology 2005;14(1):1-16.
2004: Boon Chin Heng; Tong Cao
Can RNA interference be used to expand the plasticity of autologous adult stem cells?
Journal of molecular medicine (Berlin, Germany) 2004;82(12):784-6.
2004: Boon Chin Heng; Tong Cao
The differentiation status of stem cells and their derivatives: a key consideration in transplantation medicine.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2004;50(6):626-8.
2004: Guo Qing Tong; Boon Chin Heng; N Q Chen; Wan-Yue Yip; Soon Chye Ng
Effects of elevated temperature in vivo on the maturational and developmental competence of porcine germinal vesicle stage oocytes.
Journal of animal science 2004;82(11):3175-80.
2004: Boon Chin Heng; tong cao; Guo Qing Tong; Soon Chye Ng
Potential utility of cell-permeable transcription factors to direct stem cell differentiation.
Stem cells and development 2004;13(5):460-2.
2004: Boon Chin Heng; Guo Qing Tong; Soon Chye Ng
Effects of granulosa coculture on in-vitro oocyte meiotic maturation within a putatively less competent murine model.
Theriogenology 2004;62(6):1066-92.
2004: Boon Chin Heng; Hua Liu; tong cao
Feeder cell density--a key parameter in human embryonic stem cell culture.
In vitro cellular & developmental biology. Animal 2004;40(8-9):255-7.
2004: Boon Chin Heng; tong cao; Lawrence W Stanton; Paul Robson; Bjorn Olsen
Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(9):1379-94.
2004: Boon Chin Heng; Y-J H Yu; S C Ng
Slow-cooling protocols for microcapsule cryopreservation.
Journal of microencapsulation 2004;21(4):455-67.
2004: Boon Chin Heng; Guo Qing Tong; Soon Chye Ng
Human embryonic stem cell-derived fibroblastic and epitheloid lineages as xeno-free support?
In vitro cellular & developmental biology. Animal 2004;40(5-6):129-30.
2004: Boon Chin Heng; Husnain Kh Haider; Eugene K W Sim; tong cao; Soon Chye Ng
Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro.
Cardiovascular research 2004;62(1):34-42.
2004: Boon Chin Heng; tong cao; Husnain Khawaja Haider; Dennis Zheng Ming Wang; Eugene K W Sim; Soon Chye Ng
An overview and synopsis of techniques for directing stem cell differentiation in vitro.
Cell and tissue research 2004;315(3):291-303.
2004: Boon Chin Heng; tong cao; Eng Hin Lee
Directing stem cell differentiation into the chondrogenic lineage in vitro.
Stem cells (Dayton, Ohio) 2004;22(7):1152-67.