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Hans Hengartner

Research Profile

Living Beings

Disorders

Lymphocytic Choriomeningitis

Anatomy

Chemicals & Drugs

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Neutralization Tests

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Admar Verschoor; Rolf M Zinkernagel; Patricia Graef; Hans Hengartner; Steffen Massberg; Alexander A Navarini; Michael Neuenhahn; Bernhard Nieswandt; Ann Plaumann; Amelie Seidlmeier; Dirk H Busch
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
Philipp A Lang; Mike Recher; Nadine Honke; Stefanie Scheu; Stephanie Borkens; Nicole Gailus; Caroline Krings; Andreas Meryk; Andreas Kulawik; Luisa Cervantes-Barragan; Nico van Rooijen; Ulrich Kalinke; Burkhard Ludewig; Hans Hengartner; Nicola Harris; Dieter Häussinger; Pamela S Ohashi; Rolf M Zinkernagel; Karl S Lang
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.
Alexander A Navarini; Malgorzata Krzyzowska; Karl S Lang; Edit Horvath; Hans Hengartner; Marek G Niemialtowski; Rolf M Zinkernagel
Long-lasting immunity by early infection of maternal-antibody-protected infants.

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All Publications

2011: Admar Verschoor; Rolf M Zinkernagel; Patricia Graef; Hans Hengartner; Steffen Massberg; Alexander A Navarini; Michael Neuenhahn; Bernhard Nieswandt; Ann Plaumann; Amelie Seidlmeier; Dirk H Busch
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
Nature immunology 2011;12(12):1194-201.
2010: Philipp A Lang; Mike Recher; Nadine Honke; Stefanie Scheu; Stephanie Borkens; Nicole Gailus; Caroline Krings; Andreas Meryk; Andreas Kulawik; Luisa Cervantes-Barragan; Nico van Rooijen; Ulrich Kalinke; Burkhard Ludewig; Hans Hengartner; Nicola Harris; Dieter Häussinger; Pamela S Ohashi; Rolf M Zinkernagel; Karl S Lang
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.
Hepatology (Baltimore, Md.) 2010;52(1):25-32.
2010: Alexander A Navarini; Malgorzata Krzyzowska; Karl S Lang; Edit Horvath; Hans Hengartner; Marek G Niemialtowski; Rolf M Zinkernagel
Long-lasting immunity by early infection of maternal-antibody-protected infants.
European journal of immunology 2010;40(1):113-6.
2009: Alexander A Navarini; Karl S Lang; Admar Verschoor; Mike Recher; Annelies S Zinkernagel; Victor Nizet; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7107-12.
2009: Markus B Geuking; Jacqueline Weber; Marie Dewannieux; Elieser Gorelik; Thierry Heidmann; Hans Hengartner; Rolf M Zinkernagel; Lars Hangartner
Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.
Science (New York, N.Y.) 2009;323(5912):393-6.
2008: Kathy D McCoy; Maaike Stoel; Rebecca Stettler; Patrick Merky; Katja Fink; Beatrice M Senn; Corinne Schaer; Joanna Massacand; Bernhard Odermatt; Hans C Oettgen; Rolf M Zinkernagel; Nicolaas A Bos; Hans Hengartner; Andrew J Macpherson; Nicola L Harris
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.
Cell host & microbe 2008;4(4):362-73.
2008: Philipp A Lang; Claudio Contaldo; Panco Georgiev; Ashraf Mohammad El-Badry; Mike Recher; Michael O Kurrer; Luisa Cervantes-Barragan; Burkhard Ludewig; Thomas Calzascia; Beatrice Bolinger; Doron Merkler; Bernhard Odermatt; Michael Bader; Rolf Graf; Pierre-Alain Clavien; Ahmed N Hegazy; Max Löhning; Nicola L Harris; Pamela S Ohashi; Hans Hengartner; Rolf M Zinkernagel; Karl S Lang
Aggravation of viral hepatitis by platelet-derived serotonin.
Nature medicine 2008;14(7):756-61.
2008: Max Löhning; Ahmed N Hegazy; Daniel D Pinschewer; Dorothea Busse; Karl S Lang; Thomas Höfer; Andreas Radbruch; Rolf M Zinkernagel; Hans Hengartner
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.
The Journal of experimental medicine 2008;205(1):53-61.
2008: Katja Fink; Raphaël M Zellweger; Jacqueline Weber; Nataly Manjarrez-Orduño; Martin Holdener; Beatrice M Senn; Hans Hengartner; Rolf M Zinkernagel; Andrew J Macpherson
Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.
European journal of immunology 2008;38(1):90-101.
2007: Mike Recher; Karl S Lang; Alexander A Navarini; Lukas Hunziker; Philipp A Lang; Katja Fink; Stefan Freigang; Panco Georgiev; Lars Hangartner; Raphaël M Zellweger; Andreas Bergthaler; Ahmed N Hegazy; Bruno Eschli; Alexandre Theocharides; Lukas T Jeker; Doron Merkler; Bernhard Odermatt; Martin Hersberger; Hans Hengartner; Rolf M Zinkernagel
Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.
Nature medicine 2007;13(11):1316-23.
2007: Katja Fink; Nataly Manjarrez-Orduño; Anita Schildknecht; Jacqueline Weber; Beatrice M Senn; Rolf M Zinkernagel; Hans Hengartner
B cell activation state-governed formation of germinal centers following viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5877-85.
2007: Bruno Eschli; Raphaël M Zellweger; Alexander Wepf; Karl S Lang; Katharina Quirin; Jacqueline Weber; Rolf M Zinkernagel; Hans Hengartner
Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus.
Journal of virology 2007;81(21):11650-7.
2007: Karl S Lang; Alexander A Navarini; Mike Recher; Philipp A Lang; Mathias Heikenwalder; Bärbel Stecher; Andreas Bergthaler; Bernhard Odermatt; Shizuo Akira; Kenya Honda; Hans Hengartner; Rolf M Zinkernagel
MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.
European journal of immunology 2007;37(9):2434-40.
2007: Stefan Freigang; Bruno Eschli; Nicola Harris; Markus Geuking; Katharina Quirin; Sabrina Schrempf; Raphaël M Zellweger; Jacqueline Weber; Hans Hengartner; Rolf M Zinkernagel
A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13426-31.
2007: Veronika Pochanke; Samuel Koller; Régine Dayer; Sarah Hatak; Burkhard Ludewig; Rolf M Zinkernagel; Hans Hengartner; Kathy D McCoy
Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE.
European journal of immunology 2007;37(5):1275-84.
2007: Elke Scandella; Katja Fink; Tobias Junt; Beatrice M Senn; Evelyn Lattmann; Reinhold Förster; Hans Hengartner; Burkhard Ludewig
Dendritic cell-independent B cell activation during acute virus infection: a role for early CCR7-driven B-T helper cell collaboration.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1468-76.
2007: Karl S Lang; Ahmed N Hegazy; Philipp A Lang; Bruno Eschli; Max Löhning; Hans Hengartner; Rolf M Zinkernagel; Mike Recher
"Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.
PloS one 2007;2(11):e1162.
2006: Raphaël M Zellweger; Lars Hangartner; Jacqueline Weber; Rolf M Zinkernagel; Hans Hengartner
Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection.
European journal of immunology 2006;36(12):3175-85.
2006: Alexander A Navarini; Mike Recher; Karl S Lang; Panco Georgiev; Susanne Meury; Andreas Bergthaler; Lukas Flatz; Jacques Bille; Regine Landmann; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15535-9.
2006: Marianne M Martinic; Maries van den Broek; Thomas Rülicke; Christoph Huber; Bernhard Odermatt; Walter Reith; Edit Horvath; Raphaël M Zellweger; Katja Fink; Mike Recher; Bruno Eschli; Hans Hengartner; Rolf M Zinkernagel
Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14435-40.
2006: Karl S Lang; Panco Georgiev; Mike Recher; Alexander A Navarini; Andreas Bergthaler; Mathias Heikenwalder; Nicola L Harris; Tobias Junt; Bernhard Odermatt; Pierre-Alain Clavien; Hanspeter Pircher; Shizuo Akira; Hans Hengartner; Rolf M Zinkernagel
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
The Journal of clinical investigation 2006;116(9):2456-63.
2006: Veronika Pochanke; Sarah Hatak; Hans Hengartner; Rolf M Zinkernagel; Kathy D McCoy
Induction of IgE and allergic-type responses in fur mite-infested mice.
European journal of immunology 2006;36(9):2434-45.
2006: Lars Hangartner; Raphaël M Zellweger; Mattia Giobbi; Jacqueline Weber; Bruno Eschli; Kathy D McCoy; Nicola Harris; Mike Recher; Rolf M Zinkernagel; Hans Hengartner
Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread.
The Journal of experimental medicine 2006;203(8):2033-42.
2006: Katja Fink; Karl S Lang; Nataly Manjarrez-Orduño; Tobias Junt; Beatrice M Senn; Martin Holdener; Shizuo Akira; Rolf M Zinkernagel; Hans Hengartner
Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.
European journal of immunology 2006;36(8):2094-105.
2006: Rolf M Zinkernagel; Hans Hengartner
Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological memory'.
Immunological reviews 2006;211():310-9.
2006: Bruno Eschli; Katharina Quirin; Alexander Wepf; Jacqueline Weber; Rolf M Zinkernagel; Hans Hengartner
Identification of an N-terminal trimeric coiled-coil core within arenavirus glycoprotein 2 permits assignment to class I viral fusion proteins.
Journal of virology 2006;80(12):5897-907.
2006: Kathy D McCoy; Nicola L Harris; Philipp Diener; Sarah Hatak; Bernhard Odermatt; Lars Hangartner; Beatrice M Senn; Benjamin J Marsland; Markus B Geuking; Hans Hengartner; Andrew J Macpherson; Rolf M Zinkernagel
Natural IgE production in the absence of MHC Class II cognate help.
Immunity 2006;24(3):329-39.
2006: Lars Hangartner; Rolf M Zinkernagel; Hans Hengartner
Antiviral antibody responses: the two extremes of a wide spectrum.
Nature reviews. Immunology 2006;6(3):231-43.
2006: Weldy V Bonilla; Markus B Geuking; Peter Aichele; Burkhard Ludewig; Hans Hengartner; Rolf M Zinkernagel
Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire.
The Journal of clinical investigation 2006;116(1):156-62.
2005: Tobias Junt; Katja Fink; Reinhold Förster; Beatrice M Senn; Martin Lipp; Masamichi Muramatsu; Rolf M Zinkernagel; Burkhard Ludewig; Hans Hengartner
CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7109-16.
2005: Karl S Lang; Mike Recher; Alexander A Navarini; Stefan Freigang; Nicola L Harris; Maries van den Broek; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5524-31.
2005: Karl S Lang; Mike Recher; Alexander A Navarini; Nicola L Harris; Max Löhning; Tobias Junt; Hans Christian Probst; Hans Hengartner; Rolf M Zinkernagel
Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation.
European journal of immunology 2005;35(3):738-45.
2005: Karl S Lang; Mike Recher; Tobias Junt; Alexander A Navarini; Nicola L Harris; Stefan Freigang; Bernhard Odermatt; Curdin Conrad; Lars M Ittner; Stefan Bauer; Sanjiv A Luther; Satoshi Uematsu; Shizuo Akira; Hans Hengartner; Rolf M Zinkernagel
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Nature medicine 2005;11(2):138-45.
2004: Tobias Junt; Elke Scandella; Reinhold Förster; Philippe Krebs; Stefan Krautwald; Martin Lipp; Hans Hengartner; Burkhard Ludewig
Impact of CCR7 on priming and distribution of antiviral effector and memory CTL.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6684-93.
2004: Daniel D Pinschewer; Mar Perez; Eswaraka Jeetendra; Thomas Bächi; Edit Horvath; Hans Hengartner; Michael A Whitt; Juan Carlos de la Torre; Rolf M Zinkernagel
Kinetics of protective antibodies are determined by the viral surface antigen.
The Journal of clinical investigation 2004;114(7):988-93.
2004: Mike Recher; Karl S Lang; Lukas Hunziker; Stefan Freigang; Bruno Eschli; Nicola L Harris; Alexander A Navarini; Beatrice M Senn; Katja Fink; Marius Lötscher; Lars Hangartner; Raphaël M Zellweger; Martin Hersberger; Alexandre Theocharides; Hans Hengartner; Rolf M Zinkernagel
Deliberate removal of T cell help improves virus-neutralizing antibody production.
Nature immunology 2004;5(9):934-42.
2004: Marianne M Martinic; Benedita Rocha; Kathy D McCoy; Hans Hengartner; Rolf M Zinkernagel
Role of TCR-restricting MHC density and thymic environment on selection and survival of cells expressing low-affinity T cell receptors.
European journal of immunology 2004;34(4):1041-9.
2003: Stefan Freigang; Denise Egger; Kurt Bienz; Hans Hengartner; Rolf M Zinkernagel
Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13477-82.
2003: Lars Hangartner; Beatrice M Senn; Birgit Ledermann; Ulrich Kalinke; Peter Seiler; Etienne Bucher; Raphaël M Zellweger; Katja Fink; Bernhard Odermatt; Kurt Bürki; Rolf M Zinkernagel; Hans Hengartner
Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12883-8.
2003: Lukas Hunziker; Adrian Ciurea; Mike Recher; Hans Hengartner; Rolf M Zinkernagel
Public versus personal serotypes of a viral quasispecies.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6015-20.
2003: Beatrice M Senn; Constantino López-Macías; Ulrich Kalinke; Alain Lamarre; armando isibasi; Rolf M Zinkernagel; Hans Hengartner
Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.
European journal of immunology 2003;33(4):950-61.
2003: Lukas Hunziker; Mike Recher; Andrew J Macpherson; Adrian Ciurea; Stefan Freigang; Hans Hengartner; Rolf M Zinkernagel
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections.
Nature immunology 2003;4(4):343-9.
2003: Marianne M Martinic; Thomas Rülicke; Alana Althage; Bernhard Odermatt; Matthias Höchli; Alain Lamarre; Tilman Dumrese; Daniel E Speiser; Diego Kyburz; Hans Hengartner; Rolf M Zinkernagel
Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1861-6.
2002: Lukas Hunziker; Mike Recher; Adrian Ciurea; Marianne M Martinic; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Antagonistic variant virus prevents wild-type virus-induced lethal immunopathology.
The Journal of experimental medicine 2002;196(8):1039-46.
2002: Stephan Oehen; Bernhard Odermatt; Urs Karrer; Hans Hengartner; Rolf M Zinkernagel; Constantino López-Macías
Marginal zone macrophages and immune responses against viruses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1453-8.
2002: Tobias Junt; Hideki Nakano; Tilman Dumrese; Terutaka Kakiuchi; Bernhard Odermatt; Rolf M Zinkernagel; Hans Hengartner; Burkhard Ludewig
Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6032-40.
2002: Marcus Pericin; Alana Althage; Stefan Freigang; Hans Hengartner; Eric Rolland; philippe Dupraz; Bernard Thorens; Patrick Aebischer; Rolf M Zinkernagel
Allogeneic beta-islet cells correct diabetes and resist immune rejection.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8203-6.
2002: Burkhard Ludewig; Rolf M Zinkernagel; Hans Hengartner
Arterial inflammation and atherosclerosis.
Trends in cardiovascular medicine 2002;12(4):154-9.
2002: Weldy V Bonilla; Daniel D Pinschewer; Paul Klenerman; Valentin Rousson; Mirella Gaboli; Pier P Pandolfi; Rolf M Zinkernagel; Maria Salvato; Hans Hengartner
Effects of promyelocytic leukemia protein on virus-host balance.
Journal of virology 2002;76(8):3810-8.
2001: Rolf M Zinkernagel; Hans Hengartner
Regulation of the immune response by antigen.
Science (New York, N.Y.) 2001;293(5528):251-3.
2001: Adrian Ciurea; Lukas Hunziker; Marianne M Martinic; Annette Oxenius; Hans Hengartner; Rolf M Zinkernagel
CD4+ T-cell-epitope escape mutant virus selected in vivo.
Nature medicine 2001;7(7):795-800.
2001: Andrew J Macpherson; Alain Lamarre; Kathy McCoy; G R Harriman; Bernhard Odermatt; G Dougan; Hans Hengartner; Rolf M Zinkernagel
IgA production without mu or delta chain expression in developing B cells.
Nature immunology 2001;2(7):625-31.
2001: Adrian F Ochsenbein; Sophie Sierro; Bernhard Odermatt; Marcus Pericin; Urs Karrer; J Hermans; S Hemmi; Hans Hengartner; Rolf M Zinkernagel
Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction.
Nature 2001;411(6841):1058-64.
2001: Burkhard Ludewig; Weldy V Bonilla; Tilman Dumrese; Bernhard Odermatt; Rolf M Zinkernagel; Hans Hengartner
Perforin-independent regulation of dendritic cell homeostasis by CD8(+) T cells in vivo: implications for adaptive immunotherapy.
European journal of immunology 2001;31(6):1772-9.
2001: Adrian Ciurea; Lukas Hunziker; Rolf M Zinkernagel; Hans Hengartner
Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model.
Immunogenetics 2001;53(3):185-9.
2001: Burkhard Ludewig; K McCoy; Marcus Pericin; Adrian F Ochsenbein; Tilman Dumrese; Bernhard Odermatt; R E Toes; C J Melief; Hans Hengartner; Rolf M Zinkernagel
Rapid peptide turnover and inefficient presentation of exogenous antigen critically limit the activation of self-reactive CTL by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3678-87.
2001: Burkhard Ludewig; M Jäggi; Tilman Dumrese; K Brduscha-Riem; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3369-76.
2001: Adrian Ciurea; Lukas Hunziker; Paul Klenerman; Hans Hengartner; Rolf M Zinkernagel
Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants.
The Journal of experimental medicine 2001;193(3):297-305.
2001: Rolf M Zinkernagel; Alain Lamarre; Adrian Ciurea; Lukas Hunziker; Adrian F Ochsenbein; Kathy D McCoy; Thomas Fehr; Martin F Bachmann; Ulrich Kalinke; Hans Hengartner
Neutralizing antiviral antibody responses.
Advances in immunology 2001;79():1-53.
2000: Adrian F Ochsenbein; Daniel D Pinschewer; Sophie Sierro; Edit Horvath; Hans Hengartner; Rolf M Zinkernagel
Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13263-8.
2000: Burkhard Ludewig; Stefan Freigang; M Jäggi; Michael O Kurrer; Y C Pei; L Vlk; Bernhard Odermatt; Rolf M Zinkernagel; Hans Hengartner
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12752-7.
2000: Maries van den Broek; Hans Hengartner
The role of perforin in infections and tumour surveillance.
Experimental physiology 2000;85(6):681-5.
2000: Urs Karrer; Alana Althage; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect.
European journal of immunology 2000;30(10):2799-807.
2000: Thomas Fehr; Constantino López-Macías; Bernhard Odermatt; R M Torres; Daniel Schubart; T L O'Keefe; Patrick Matthias; Hans Hengartner; Rolf M Zinkernagel
Correlation of anti-viral B cell responses and splenic morphology with expression of B cell-specific molecules.
International immunology 2000;12(9):1275-84.
2000: Burkhard Ludewig; F Barchiesi; Marcus Pericin; Rolf M Zinkernagel; Hans Hengartner; Reto Schwendener
In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity.
Vaccine 2000;19(1):23-32.
2000: Peter Seiler; Beatrice M Senn; Paul Klenerman; Ulrich Kalinke; Hans Hengartner; Rolf M Zinkernagel
Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.
Journal of virology 2000;74(13):5896-901.
2000: Andrew J Macpherson; D Gatto; E Sainsbury; G R Harriman; Hans Hengartner; Rolf M Zinkernagel
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.
Science (New York, N.Y.) 2000;288(5474):2222-6.
2000: KJ Maloy; C Burkhart; Tobias Junt; Bernhard Odermatt; A Oxenius; L Piali; Rolf M Zinkernagel; Hans Hengartner
CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability.
The Journal of experimental medicine 2000;191(12):2159-70.
2000: Adrian F Ochsenbein; Daniel D Pinschewer; Bernhard Odermatt; Adrian Ciurea; Hans Hengartner; Rolf M Zinkernagel
Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6296-302.
2000: Daniel D Pinschewer; Adrian F Ochsenbein; Bernhard Odermatt; Volker Brinkmann; Hans Hengartner; Rolf M Zinkernagel
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5761-70.
2000: W Barchet; Stephan Oehen; Paul Klenerman; Dominik Wodarz; Gennady Bocharov; Alun L Lloyd; Martin A Nowak; Hans Hengartner; Rolf M Zinkernagel; Stephan Ehl
Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo.
European journal of immunology 2000;30(5):1356-63.
2000: Adrian Ciurea; Paul Klenerman; Lukas Hunziker; E Horvath; Beatrice M Senn; Adrian F Ochsenbein; Hans Hengartner; Rolf M Zinkernagel
Viral persistence in vivo through selection of neutralizing antibody-escape variants.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2749-54.
2000: Burkhard Ludewig; Adrian F Ochsenbein; Bernhard Odermatt; D Paulin; Hans Hengartner; Rolf M Zinkernagel
Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease.
The Journal of experimental medicine 2000;191(5):795-804.
2000: Stephan Ehl; W Barchet; Stephan Oehen; Peter Aichele; J Hombach; Hans Hengartner; Rolf M Zinkernagel
Donor cell persistence and activation-induced unresponsiveness of peripheral CD8+ T cells.
European journal of immunology 2000;30(3):883-91.
2000: Urs Karrer; Constantino López-Macías; Annette Oxenius; Bernhard Odermatt; M F Bachmann; Ulrich Kalinke; Horst Bluethmann; Hans Hengartner; Rolf M Zinkernagel
Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):768-78.
2000: Burkhard Ludewig; KJ Maloy; C López-Macías; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Induction of optimal anti-viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs.
European journal of immunology 2000;30(1):185-96.
1999: Adrian F Ochsenbein; Thomas Fehr; C Lutz; M Suter; F Brombacher; Hans Hengartner; Rolf M Zinkernagel
Control of early viral and bacterial distribution and disease by natural antibodies.
Science (New York, N.Y.) 1999;286(5447):2156-9.
1999: Adrian F Ochsenbein; Daniel D Pinschewer; Bernhard Odermatt; M C Carroll; Hans Hengartner; Rolf M Zinkernagel
Protective T cell-independent antiviral antibody responses are dependent on complement.
The Journal of experimental medicine 1999;190(8):1165-74.
1999: Adrian Ciurea; Paul Klenerman; Lukas Hunziker; E Horvath; Bernhard Odermatt; Adrian F Ochsenbein; Hans Hengartner; Rolf M Zinkernagel
Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11964-9.
1999: Daniel D Pinschewer; Adrian F Ochsenbein; Anne B Satterthwaite; O N Witte; Hans Hengartner; Rolf M Zinkernagel
A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion.
European journal of immunology 1999;29(9):2981-7.
1999: Burkhard Ludewig; Stephan Oehen; F Barchiesi; Reto Schwendener; Hans Hengartner; Rolf M Zinkernagel
Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1839-44.
1999: Adrian F Ochsenbein; Urs Karrer; Paul Klenerman; Alana Althage; Adrian Ciurea; H Shen; J F Miller; J L Whitton; Hans Hengartner; Rolf M Zinkernagel
A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9293-8.
1999: Constantino López-Macías; Ulrich Kalinke; Marilia I Cascalho; Matthias Wabl; Hans Hengartner; Rolf M Zinkernagel; Alain Lamarre
Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses.
The Journal of experimental medicine 1999;189(11):1791-8.
1999: Burkhard Ludewig; Bernhard Odermatt; Adrian F Ochsenbein; Rolf M Zinkernagel; Hans Hengartner
Role of dendritic cells in the induction and maintenance of autoimmune diseases.
Immunological reviews 1999;169():45-54.
1999: Annette Oxenius; Marianne M Martinic; Hans Hengartner; Paul Klenerman
CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines.
Journal of virology 1999;73(5):4120-6.
1999: Peter Seiler; Beatrice M Senn; MA Bründler; Rolf M Zinkernagel; Hans Hengartner; Ulrich Kalinke
In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4536-41.
1999: Rolf M Zinkernagel; Oliver Planz; Stephan Ehl; M Battegay; Bernhard Odermatt; Paul Klenerman; Hans Hengartner
General and specific immunosuppression caused by antiviral T-cell responses.
Immunological reviews 1999;168():305-15.
1999: Adrian F Ochsenbein; Paul Klenerman; Urs Karrer; Burkhard Ludewig; Marcus Pericin; Hans Hengartner; Rolf M Zinkernagel
Immune surveillance against a solid tumor fails because of immunological ignorance.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2233-8.
1999: KJ Maloy; C Burkhart; G Freer; Thomas Rülicke; Hanspeter Pircher; Dwight H Kono; Argyrios N Theofilopoulos; Burkhard Ludewig; Urs Hoffmann-Rohrer; Rolf M Zinkernagel; Hans Hengartner
Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2867-74.
1999: Ulrich Steinhoff; KJ Maloy; C Burkhart; A J Clark; Thomas Rülicke; Hans Hengartner; Rolf M Zinkernagel
Variable immune response against a developmentally regulated self-antigen.
Journal of autoimmunity 1999;12(1):27-34.
1999: Annette Oxenius; Urs Karrer; Rolf M Zinkernagel; Hans Hengartner
IL-12 is not required for induction of type 1 cytokine responses in viral infections.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):965-73.
1998: G A Funk; A D Barbour; Hans Hengartner; Ulrich Kalinke
Mathematical model of a virus-neutralizing immunglobulin response.
Journal of theoretical biology 1998;195(1):41-52.
1998: Burkhard Ludewig; Bernhard Odermatt; S Landmann; Hans Hengartner; Rolf M Zinkernagel
Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue.
The Journal of experimental medicine 1998;188(8):1493-501.
1998: Awen Gallimore; J Hombach; Tilman Dumrese; Hans-Georg Rammensee; Rolf M Zinkernagel; Hans Hengartner
A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells.
European journal of immunology 1998;28(10):3301-11.
1998: Annette Oxenius; Rolf M Zinkernagel; Hans Hengartner
Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection.
Immunity 1998;9(4):449-57.
1998: Stephan Ehl; Peter Aichele; H Ramseier; W Barchet; J Hombach; Hanspeter Pircher; Hans Hengartner; Rolf M Zinkernagel
Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection.
Nature medicine 1998;4(9):1015-9.
1998: Awen Gallimore; Hans Hengartner; Rolf M Zinkernagel
Hierarchies of antigen-specific cytotoxic T-cell responses.
Immunological reviews 1998;164():29-36.
1998: Thomas Fehr; Hussein Y Naim; Martin F Bachmann; Adrian F Ochsenbein; P Spielhofer; Etienne Bucher; Hans Hengartner; Martin A Billeter; Rolf M Zinkernagel
T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses.
Nature medicine 1998;4(8):945-8.
1998: Thomas Fehr; R C Rickert; Bernhard Odermatt; J Roes; K Rajewsky; Hans Hengartner; Rolf M Zinkernagel
Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19.
The Journal of experimental medicine 1998;188(1):145-55.
1998: Awen Gallimore; K Schwarz; Maries van den Broek; Hans Hengartner; Marcus Groettrup
The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader-derived T cell epitope.
Molecular immunology 1998;35(10):581-91.
1998: D Binder; Maries van den Broek; D Kägi; H Bluethmann; J Fehr; Hans Hengartner; Rolf M Zinkernagel
Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus.
The Journal of experimental medicine 1998;187(11):1903-20.
1998: Awen Gallimore; Tilman Dumrese; Hans Hengartner; Rolf M Zinkernagel; Hans-Georg Rammensee
Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides.
The Journal of experimental medicine 1998;187(10):1647-57.
1998: Awen Gallimore; A Glithero; Andrew Godkin; A C Tissot; A Plückthun; Tim Elliott; Hans Hengartner; Rolf M Zinkernagel
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.
The Journal of experimental medicine 1998;187(9):1383-93.
1998: Burkhard Ludewig; S Ehl; Urs Karrer; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Dendritic cells efficiently induce protective antiviral immunity.
Journal of virology 1998;72(5):3812-8.
1998: Stephan Ehl; J Hombach; Peter Aichele; Thomas Rülicke; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel; Hanspeter Pircher
Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology.
The Journal of experimental medicine 1998;187(5):763-74.
1998: Peter Seiler; Ulrich Kalinke; Thomas Rülicke; Etienne Bucher; C Böse; Rolf M Zinkernagel; Hans Hengartner
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice.
Journal of virology 1998;72(3):2253-8.
1998: Peter Seiler; MA Bründler; C Zimmermann; D Weibel; M Bruns; Hans Hengartner; Rolf M Zinkernagel
Induction of protective cytotoxic T cell responses in the presence of high titers of virus-neutralizing antibodies: implications for passive and active immunization.
The Journal of experimental medicine 1998;187(4):649-54.
1998: Kevin Maloy; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1160-5.
1998: A Oxenius; Rolf M Zinkernagel; Hans Hengartner
CD4+ T-cell induction and effector functions: a comparison of immunity against soluble antigens and viral infections.
Advances in immunology 1998;70():313-67.
1998: Annette Oxenius; Martin F Bachmann; Rolf M Zinkernagel; Hans Hengartner
Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection.
European journal of immunology 1998;28(1):390-400.
1997: Stephan Ehl; Paul Klenerman; Peter Aichele; Hans Hengartner; Rolf M Zinkernagel
A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro.
European journal of immunology 1997;27(12):3404-13.
1997: P Klenerman; Hans Hengartner; Rolf M Zinkernagel
A non-retroviral RNA virus persists in DNA form.
Nature 1997;390(6657):298-301.
1997: D Kägi; B Odermatt; P Seiler; Rolf M Zinkernagel; T W Mak; Hans Hengartner
Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice.
The Journal of experimental medicine 1997;186(7):989-97.
1997: Peter Seiler; Peter Aichele; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel; Reto Schwendener
Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection.
European journal of immunology 1997;27(10):2626-33.
1997: Maries van den Broek; R Spörri; C Even; P G Plagemann; Edgar Hänseler; Hans Hengartner; Rolf M Zinkernagel
Lactate dehydrogenase-elevating virus (LDV): lifelong coexistence of virus and LDV-specific immunity.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1585-8.
1997: Martin F Bachmann; Ulrich Kalinke; Alana Althage; G Freer; C Burkhart; H Roost; M Aguet; Hans Hengartner; Rolf M Zinkernagel
The role of antibody concentration and avidity in antiviral protection.
Science (New York, N.Y.) 1997;276(5321):2024-7.
1997: Oliver Planz; Stephan Ehl; Esther Furrer; Edit Horvath; MA Bründler; Hans Hengartner; Rolf M Zinkernagel
A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6874-9.
1997: Urs Karrer; Alana Althage; Bernhard Odermatt; Charles M Roberts; S J Korsmeyer; S Miyawaki; Hans Hengartner; Rolf M Zinkernagel
On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.
The Journal of experimental medicine 1997;185(12):2157-70.
1997: Annette Oxenius; Martin F Bachmann; D Mathis; C Benoist; Rolf M Zinkernagel; Hans Hengartner
Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5717-26.
1997: Martin F Bachmann; Thomas Fehr; G Freer; Hans Hengartner; Rolf M Zinkernagel
Correlation of tolerogenicity of a viral antigen with its immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5106-11.
1997: Thomas Fehr; Martin F Bachmann; Etienne Bucher; Ulrich Kalinke; F E Di Padova; A B Lang; Hans Hengartner; Rolf M Zinkernagel
Role of repetitive antigen patterns for induction of antibodies against antibodies.
The Journal of experimental medicine 1997;185(10):1785-92.
1997: Peter Aichele; K Brduscha-Riem; Stephan Oehen; Bernhard Odermatt; Rolf M Zinkernagel; Hans Hengartner; Hanspeter Pircher
Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology.
Immunity 1997;6(5):519-29.
1997: Stephan Ehl; J Hombach; Peter Aichele; Hans Hengartner; Rolf M Zinkernagel
Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model.
The Journal of experimental medicine 1997;185(7):1241-51.
1997: Rolf M Zinkernagel; Stephan Ehl; Peter Aichele; Stephan Oehen; Thomas M Kündig; Hans Hengartner
Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity.
Immunological reviews 1997;156():199-209.
1997: D Binder; J Fehr; Hans Hengartner; Rolf M Zinkernagel
Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus.
The Journal of experimental medicine 1997;185(3):517-30.
1997: Martin F Bachmann; Thomas M Kündig; Hans Hengartner; Rolf M Zinkernagel
Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):640-5.
1996: Stephan Ehl; Reto Nüesch; Takao Tanaka; M Myasaka; Hans Hengartner; Rolf M Zinkernagel
A comparison of efficacy and specificity of three NK depleting antibodies.
Journal of immunological methods 1996;199(2):149-53.
1996: Hans Hengartner
Transgenic mice to study viral pathogenesis and autoimmunity.
International journal of experimental pathology 1996;77(6):279-82.
1996: Ulrich Kalinke; Etienne Bucher; B Ernst; A Oxenius; H P Roost; Stephan Geley; Reinhard Kofler; Rolf M Zinkernagel; Hans Hengartner
The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus.
Immunity 1996;5(6):639-52.
1996: Ulrich Kalinke; A Krebber; C Krebber; Etienne Bucher; Andreas Plückthun; Rolf M Zinkernagel; Hans Hengartner
Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection.
European journal of immunology 1996;26(12):2801-6.
1996: M E van den Broek; D Kägi; F Ossendorp; René E M Toes; S Vamvakas; W K Lutz; C J Melief; Rolf M Zinkernagel; Hans Hengartner
Decreased tumor surveillance in perforin-deficient mice.
The Journal of experimental medicine 1996;184(5):1781-90.
1996: Emilia Ghelardi; C Burkhart; Sonia Senesi; Hans Hengartner; Giulia Freer
Cloning of an unidentified T-cell receptor alpha chain gene from a vesicular stomatitis virus-specific helper T-cell clone.
Immunology letters 1996;53(1):31-9.
1996: TM Kündig; Martin F Bachmann; Stephan Oehen; U W Hoffmann; J J Simard; C P Kalberer; Hanspeter Pircher; Pamela S Ohashi; Hans Hengartner; Rolf M Zinkernagel
On the role of antigen in maintaining cytotoxic T-cell memory.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9716-23.
1996: Oliver Planz; P Seiler; Hans Hengartner; Rolf M Zinkernagel
Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected].
Nature 1996;382(6593):726-9.
1996: Peter Aichele; Martin F Bachmann; Hans Hengartner; Rolf M Zinkernagel
Immunopathology or organ-specific autoimmunity as a consequence of virus infection.
Immunological reviews 1996;152():21-45.
1996: Martin F Bachmann; B Odermatt; Hans Hengartner; Rolf M Zinkernagel
Induction of long-lived germinal centers associated with persisting antigen after viral infection.
The Journal of experimental medicine 1996;183(5):2259-69.
1996: Annette Oxenius; K A Campbell; Charles R Maliszewski; T Kishimoto; H Kikutani; Hans Hengartner; Rolf M Zinkernagel; Martin F Bachmann
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.
The Journal of experimental medicine 1996;183(5):2209-18.
1996: D Kägi; B Odermatt; Pamela S Ohashi; Rolf M Zinkernagel; Hans Hengartner
Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity.
The Journal of experimental medicine 1996;183(5):2143-52.
1996: Stephan Ehl; Urs Hoffmann-Rohrer; S Nagata; Hans Hengartner; Rolf M Zinkernagel
Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2357-60.
1996: Thomas Fehr; Martin F Bachmann; Horst Bluethmann; H Kikutani; Hans Hengartner; Rolf M Zinkernagel
T-independent activation of B cells by vesicular stomatitis virus: no evidence for the need of a second signal.
Cellular immunology 1996;168(2):184-92.
1996: H P Roost; A Haag; C Burkhart; Rolf M Zinkernagel; Hans Hengartner
Mapping of the dominant neutralizing antigenic site of a virus using infected cells.
Journal of immunological methods 1996;189(2):233-42.
1996: M Battegay; Martin F Bachmann; C Burhkart; S Viville; C Benoist; D Mathis; Hans Hengartner; Rolf M Zinkernagel
Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.
Cellular immunology 1996;167(1):115-21.
1996: Rolf M Zinkernagel; Martin F Bachmann; TM Kündig; Stephan Oehen; H Pirchet; Hans Hengartner
On immunological memory.
Annual review of immunology 1996;14():333-67.
1996: D Kägi; Birgit Ledermann; K Bürki; Rolf M Zinkernagel; Hans Hengartner
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.
Annual review of immunology 1996;14():207-32.
1995: Maries van den Broek; D Kägi; Rolf M Zinkernagel; Hans Hengartner
Perforin dependence of natural killer cell-mediated tumor control in vivo.
European journal of immunology 1995;25(12):3514-6.
1995: Martin F Bachmann; Hans Hengartner; Rolf M Zinkernagel
T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction?
European journal of immunology 1995;25(12):3445-51.
1995: Annette Oxenius; Martin F Bachmann; P G Ashton-Rickardt; Susumu Tonegawa; Rolf M Zinkernagel; Hans Hengartner
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system.
European journal of immunology 1995;25(12):3402-11.
1995: Thomas Stallmach; T Ehrenstein; S Isenmann; C Müller; Hans Hengartner; D Kägi
The role of perforin-expression by granular metrial gland cells in pregnancy.
European journal of immunology 1995;25(12):3342-8.
1995: D Kägi; P Seiler; Jovan Pavlovic; Birgit Ledermann; K Bürki; Rolf M Zinkernagel; Hans Hengartner
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses.
European journal of immunology 1995;25(12):3256-62.
1995: D Brändle; K Brduscha-Riem; A C Hayday; M J Owen; Hans Hengartner; Hanspeter Pircher
T cell development and repertoire of mice expressing a single T cell receptor alpha chain.
European journal of immunology 1995;25(9):2650-5.
1995: Martin F Bachmann; H Schorle; R Kühn; Werner Muller; Hans Hengartner; Rolf M Zinkernagel; Ivan Horak
Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
Journal of virology 1995;69(8):4842-6.
1995: D Kägi; Birgit Ledermann; K Bürki; Rolf M Zinkernagel; Hans Hengartner
Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance.
Immunological reviews 1995;146():95-115.
1995: Peter Aichele; K Brduscha-Riem; Rolf M Zinkernagel; Hans Hengartner; Hanspeter Pircher
T cell priming versus T cell tolerance induced by synthetic peptides.
The Journal of experimental medicine 1995;182(1):261-6.
1995: TM Kündig; Martin F Bachmann; C DiPaolo; J J Simard; M Battegay; Heinz Lother; A Gessner; Klaus Kühlcke; Pamela S Ohashi; Hans Hengartner
Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
Science (New York, N.Y.) 1995;268(5215):1343-7.
1995: Martin F Bachmann; Annette Oxenius; Hanspeter Pircher; Hans Hengartner; P A Ashton-Richardt; Susumu Tonegawa; Rolf M Zinkernagel
TAP1-independent loading of class I molecules by exogenous viral proteins.
European journal of immunology 1995;25(6):1739-43.
1995: Giulia Freer; C Burkhart; Thomas Rülicke; Emilia Ghelardi; Urs Hoffmann-Rohrer; Hanspeter Pircher; Rolf M Zinkernagel; Hans Hengartner
Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor beta chain transgenic mouse.
European journal of immunology 1995;25(5):1410-6.
1995: U Steinhoff; U Müller; A Schertler; Hans Hengartner; M Aguet; Rolf M Zinkernagel
Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.
Journal of virology 1995;69(4):2153-8.
1995: H P Roost; Martin F Bachmann; A Haag; Ulrich Kalinke; V Pliska; Hans Hengartner; Rolf M Zinkernagel
Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1257-61.
1995: M Schulz; Henk-Jan Schuurman; Joanne Joergensen; C Steiner; T Meerloo; D Kägi; Hans Hengartner; Rolf M Zinkernagel; MH Schreier; K Bürki
Acute rejection of vascular heart allografts by perforin-deficient mice.
European journal of immunology 1995;25(2):474-80.
1995: Rolf M Zinkernagel; Hans Hengartner
Viral immunopathology. Introduction.
Springer seminars in immunopathology 1995;17(2-3):119-20.
1994: D Kägi; Birgit Ledermann; K Bürki; Hans Hengartner; Rolf M Zinkernagel
CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.
European journal of immunology 1994;24(12):3068-72.
1994: Martin F Bachmann; Urs Hoffmann-Rohrer; Ulrich Steinhoff; K Bürki; S Skuntz; Heinz Arnheiter; Hans Hengartner; Rolf M Zinkernagel
T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice.
European journal of immunology 1994;24(12):2966-73.
1994: Martin F Bachmann; Hans Hengartner; Rolf M Zinkernagel
Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction.
Medical microbiology and immunology 1994;183(6):315-24.
1994: Martin F Bachmann; TM Kündig; B Odermatt; Hans Hengartner; Rolf M Zinkernagel
Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3386-97.
1994: Stephan Oehen; Pamela S Ohashi; K Bürki; Hans Hengartner; Rolf M Zinkernagel; Peter Aichele
Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels.
Cellular immunology 1994;158(2):342-52.
1994: Martin F Bachmann; TM Kündig; Hans Hengartner; Rolf M Zinkernagel
Regulation of IgG antibody titers by the amount persisting of immune-complexed antigen.
European journal of immunology 1994;24(10):2567-70.
1994: Martin F Bachmann; TM Kündig; Giulia Freer; Y Li; C Y Kang; D H Bishop; Hans Hengartner; Rolf M Zinkernagel
Induction of protective cytotoxic T cells with viral proteins.
European journal of immunology 1994;24(9):2228-36.
1994: Hanspeter Pircher; Pamela S Ohashi; R L Boyd; Hans Hengartner; K Brduscha
Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules.
European journal of immunology 1994;24(9):1982-7.
1994: D Kägi; F Vignaux; Birgit Ledermann; K Bürki; V Depraetere; S Nagata; Hans Hengartner; Pierre Golstein
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
Science (New York, N.Y.) 1994;265(5171):528-30.
1994: M Battegay; Dimitrios Moskofidis; Amin Rahemtulla; Hans Hengartner; T W Mak; Rolf M Zinkernagel
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.
Journal of virology 1994;68(7):4700-4.
1994: Rolf M Zinkernagel; Hans Hengartner
T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS.
Immunology today 1994;15(6):262-8.
1994: Giulia Freer; C Burkhart; I Ciernik; Martin F Bachmann; Hans Hengartner; Rolf M Zinkernagel
Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen.
Journal of virology 1994;68(6):3650-5.
1994: Dimitrios Moskofidis; F Lechner; Hans Hengartner; Rolf M Zinkernagel
MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):4976-83.
1994: D Kägi; Birgit Ledermann; K Bürki; P Seiler; B Odermatt; K J Olsen; Eckhard R Podack; Rolf M Zinkernagel; Hans Hengartner
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice.
Nature 1994;369(6475):31-7.
1994: Martin F Bachmann; C Bast; Hans Hengartner; Rolf M Zinkernagel
Immunogenicity of a viral model vaccine after different inactivation procedures.
Medical microbiology and immunology 1994;183(2):95-104.
1994: Martin F Bachmann; TM Kündig; C P Kalberer; Hans Hengartner; Rolf M Zinkernagel
How many specific B cells are needed to protect against a virus?
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4235-41.
1994: Ulrich Steinhoff; C Burkhart; Heinz Arnheiter; Hans Hengartner; Rolf M Zinkernagel
Virus or a hapten-carrier complex can activate autoreactive B cells by providing linked T help.
European journal of immunology 1994;24(3):773-6.
1994: C Burkhart; Giulia Freer; R Castro; L Adorini; K H Wiesmüller; Rolf M Zinkernagel; Hans Hengartner
Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus.
Journal of virology 1994;68(3):1573-80.
1994: Peter Aichele; D Kyburz; Pamela S Ohashi; B Odermatt; Rolf M Zinkernagel; Hans Hengartner; Hanspeter Pircher
Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):444-8.
1994: D Brändle; S Müller; C Müller; Hans Hengartner; Hanspeter Pircher
Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection.
European journal of immunology 1994;24(1):145-51.
1994: C Burkhart; Giulia Freer; Ulrich Steinhoff; Y Li; D H Bishop; Rolf M Zinkernagel; Hans Hengartner
Localization of T helper cell epitopes in the vesicular stomatitis virus: the nucleoprotein is responsible for serotype cross-reactive T help.
Viral immunology 1994;7(3):103-11.
1994: Hans Hengartner
[Viral antigen induced autoimmunity: an animal model for diabetes mellitus type I].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():177-9.
1993: M Battegay; D Kyburz; Hans Hengartner; Rolf M Zinkernagel
Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells.
European journal of immunology 1993;23(12):3236-41.
1993: Martin F Bachmann; Urs Hoffmann-Rohrer; TM Kündig; K Bürki; Hans Hengartner; Rolf M Zinkernagel
The influence of antigen organization on B cell responsiveness.
Science (New York, N.Y.) 1993;262(5138):1448-51.
1993: M Battegay; Dimitrios Moskofidis; H Waldner; M A Bründler; W P Fung-Leung; T W Mak; Hans Hengartner; Rolf M Zinkernagel
Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5408-15.
1993: TM Kündig; H Schorle; Martin F Bachmann; Hans Hengartner; Rolf M Zinkernagel; Ivan Horak
Immune responses in interleukin-2-deficient mice.
Science (New York, N.Y.) 1993;262(5136):1059-61.
1993: D Kyburz; Peter Aichele; D E Speiser; Hans Hengartner; Rolf M Zinkernagel; Hanspeter Pircher
T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides.
European journal of immunology 1993;23(8):1956-62.
1993: Martin F Bachmann; TM Kündig; C P Kalberer; Hans Hengartner; Rolf M Zinkernagel
Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses.
Journal of virology 1993;67(7):3917-22.
1993: D Kyburz; D E Speiser; M Battegay; Hans Hengartner; Rolf M Zinkernagel
Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins.
European journal of immunology 1993;23(7):1540-5.
1993: Pamela S Ohashi; Stephan Oehen; Peter Aichele; Hanspeter Pircher; B Odermatt; P Herrera; Y Higuchi; K Buerki; Hans Hengartner; Rolf M Zinkernagel
Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5185-94.
1993: Rolf M Zinkernagel; Dimitrios Moskofidis; TM Kündig; Stephan Oehen; Hanspeter Pircher; Hans Hengartner
Effector T-cell induction and T-cell memory versus peripheral deletion of T cells.
Immunological reviews 1993;133():199-223.
1993: TM Kündig; I Castelmur; Martin F Bachmann; D Abraham; D Binder; Hans Hengartner; Rolf M Zinkernagel
Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.
Journal of virology 1993;67(6):3680-3.
1993: D Kyburz; D E Speiser; T Aebischer; Hans Hengartner; Rolf M Zinkernagel
Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5051-8.
1993: TM Kündig; Martin F Bachmann; L Lefrancois; L Puddington; Hans Hengartner; Rolf M Zinkernagel
Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4450-6.
1993: TM Kündig; Hans Hengartner; Rolf M Zinkernagel
T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2316-21.
1993: Hanspeter Pircher; K Brduscha; U Steinhoff; M Kasai; T Mizuochi; Rolf M Zinkernagel; Hans Hengartner; Bruno Kyewski; K P Müller
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells.
European journal of immunology 1993;23(3):669-74.
1993: Rolf M Zinkernagel; Hans Hengartner
Contra: CD8+ T-cell-mediated suppression without 'suppressor' T cells?
International archives of allergy and immunology 1993;100(1):8-11.
1993: TM Kündig; C P Kalberer; Hans Hengartner; Rolf M Zinkernagel
Vaccination with two different vaccinia recombinant viruses: long-term inhibition of secondary vaccination.
Vaccine 1993;11(11):1154-8.
1992: Stephan Oehen; Pamela S Ohashi; Peter Aichele; K Bürki; Hans Hengartner; Rolf M Zinkernagel
Vaccination or tolerance to prevent diabetes.
European journal of immunology 1992;22(12):3149-53.
1992: Stephan Oehen; H Waldner; TM Kündig; Hans Hengartner; Rolf M Zinkernagel
Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.
The Journal of experimental medicine 1992;176(5):1273-81.
1992: D Brändle; C Müller; Thomas Rülicke; Hans Hengartner; Hanspeter Pircher
Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9529-33.
1992: Hanspeter Pircher; K P Müller; Bruno Kyewski; Hans Hengartner
Thymocytes can tolerize thymocytes by clonal deletion in vitro.
International immunology 1992;4(9):1065-9.
1992: TM Kündig; Alana Althage; Hans Hengartner; Rolf M Zinkernagel
Skin test to assess virus-specific cytotoxic T-cell activity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7757-61.
1992: D E Speiser; D Kyburz; U Stübi; Hans Hengartner; Rolf M Zinkernagel
Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):972-80.
1992: Rolf M Zinkernagel; Hans Hengartner
Virally induced immunosuppression.
Current opinion in immunology 1992;4(4):408-12.
1992: R Schneider; Hanspeter Pircher; D E Speiser; Rolf M Zinkernagel; Hans Hengartner
Kinetics of clonal deletion varies with tolerizing antigen.
Thymus 1992;20(1):5-15.
1992: Alana Althage; B Odermatt; Dimitrios Moskofidis; TM Kündig; Urs Hoffmann-Rohrer; Hans Hengartner; Rolf M Zinkernagel
Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation.
European journal of immunology 1992;22(7):1803-12.
1992: Dimitrios Moskofidis; Hanspeter Pircher; I Ciernik; B Odermatt; Hans Hengartner; Rolf M Zinkernagel
Suppression of virus-specific antibody production by CD8+ class I-restricted antiviral cytotoxic T cells in vivo.
Journal of virology 1992;66(6):3661-8.
1992: D E Speiser; Hanspeter Pircher; Pamela S Ohashi; D Kyburz; Hans Hengartner; Rolf M Zinkernagel
Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.
The Journal of experimental medicine 1992;175(5):1277-83.
1992: M Battegay; Stephan Oehen; M Schulz; Hans Hengartner; Rolf M Zinkernagel
Vaccination with a synthetic peptide modulates lymphocytic choriomeningitis virus-mediated immunopathology.
Journal of virology 1992;66(2):1199-201.
1992: Hanspeter Pircher; N Rebaï; M Groettrup; Claude Grégoire; D E Speiser; M P Happ; E Palmer; Rolf M Zinkernagel; Hans Hengartner; Bernard Malissen
Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody.
European journal of immunology 1992;22(2):399-404.
1992: Rolf M Zinkernagel; H Pircher; P S Ohashi; Hans Hengartner
T cells causing immunological disease.
Springer seminars in immunopathology 1992;14(2):105-13.
1991: T Aebischer; Dimitrios Moskofidis; Urs Hoffmann-Rohrer; Rolf M Zinkernagel; Hans Hengartner
In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11047-51.
1991: B Odermatt; M Eppler; T P Leist; Hans Hengartner; Rolf M Zinkernagel
Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8252-6.
1991: D Brändle; K Bürki; V A Wallace; Urs Hoffmann-Rohrer; Tak W Mak; B Malissen; Hans Hengartner; Hanspeter Pircher
Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition.
European journal of immunology 1991;21(9):2195-202.
1991: Rolf M Zinkernagel; Hanspeter Pircher; Pamela S Ohashi; Stephan Oehen; B Odermatt; T Mak; H Arnheiter; K Bürki; Hans Hengartner
T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease.
Immunological reviews 1991;122():133-71.
1991: Hanspeter Pircher; Urs Hoffmann-Rohrer; Dimitrios Moskofidis; Rolf M Zinkernagel; Hans Hengartner
Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.
Nature 1991;351(6326):482-5.
1991: M Battegay; S Cooper; Alana Althage; J Bänziger; Hans Hengartner; Rolf M Zinkernagel
Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates.
Journal of virological methods 1991;33(1-2):191-8.
1991: M Schulz; P Aichele; R Schneider; T H Hansen; Rolf M Zinkernagel; Hans Hengartner
Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide.
European journal of immunology 1991;21(5):1181-5.
1991: Pamela S Ohashi; Stephan Oehen; K Buerki; Hanspeter Pircher; C T Ohashi; B Odermatt; B Malissen; Rolf M Zinkernagel; Hans Hengartner
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice.
Cell 1991;65(2):305-17.
1991: M Schulz; Rolf M Zinkernagel; Hans Hengartner
Peptide-induced antiviral protection by cytotoxic T cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):991-3.
1991: Stephan Oehen; Hans Hengartner; Rolf M Zinkernagel
Vaccination for disease.
Science (New York, N.Y.) 1991;251(4990):195-8.
1990: E Rüedi; Hans Hengartner; Rolf M Zinkernagel
Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody responses.
Cellular immunology 1990;130(2):501-12.
1990: Pamela S Ohashi; Hanspeter Pircher; K Bürki; Rolf M Zinkernagel; Hans Hengartner
Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.
Nature 1990;346(6287):861-3.
1990: Hanspeter Pircher; Dimitrios Moskofidis; Urs Hoffmann-Rohrer; K Bürki; Hans Hengartner; Rolf M Zinkernagel
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.
Nature 1990;346(6285):629-33.
1990: Rolf M Zinkernagel; S Cooper; J Chambers; R A Lazzarini; Hans Hengartner; Heinz Arnheiter
Virus-induced autoantibody response to a transgenic viral antigen.
Nature 1990;345(6270):68-71.
1990: P Aichele; Hans Hengartner; Rolf M Zinkernagel; M Schulz
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.
The Journal of experimental medicine 1990;171(5):1815-20.
1990: P Groscurth; S Diener; Rolf A Stahel; L Jost; D Kägi; Hans Hengartner
Morphologic analysis of human lymphokine-activated killer (LAK) cells.
International journal of cancer. Journal international du cancer 1990;45(4):694-704.
1990: Pamela S Ohashi; V A Wallace; H Broughton; C T Ohashi; D A Ferrick; V Jost; Tak W Mak; Hans Hengartner; Hanspeter Pircher
Specific deletion of the J-C delta locus in murine alpha/beta T cell clones and studies using transgenic mice.
European journal of immunology 1990;20(3):517-22.
1990: D E Speiser; Thomas Zürcher; H Ramseier; Hans Hengartner; P Staeheli; Otto Haller; Rolf M Zinkernagel
Nuclear myxovirus-resistance protein Mx is a minor histocompatibility antigen.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):2021-5.
1990: T Aebischer; Stephan Oehen; Hans Hengartner
Preferential usage of V alpha 4 and V beta 10 T cell receptor genes by lymphocytic choriomeningitis virus glycoprotein-specific H-2Db-restricted cytotoxic T cells.
European journal of immunology 1990;20(3):523-31.
1990: Hanspeter Pircher; Pamela S Ohashi; G Miescher; R Lang; A Zikopoulos; K Bürki; Tak W Mak; H R MacDonald; Hans Hengartner
T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.
European journal of immunology 1990;20(2):417-24.
1990: M Kohler; B Rüttner; S Cooper; Hans Hengartner; Rolf M Zinkernagel
Enhanced tumor susceptibility of immunocompetent mice infected with lymphocytic choriomeningitis virus.
Cancer immunology, immunotherapy : CII 1990;32(2):117-24.
1989: D E Speiser; Rosemary K Lees; Hans Hengartner; Rolf M Zinkernagel; H Robson MacDonald
Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus.
The Journal of experimental medicine 1989;170(6):2165-70.
1989: Hanspeter Pircher; K Bürki; R Lang; Hans Hengartner; Rolf M Zinkernagel
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen.
Nature 1989;342(6249):559-61.
1989: M Schulz; P Aichele; M Vollenweider; F W Bobe; F Cardinaux; Hans Hengartner; Rolf M Zinkernagel
Major histocompatibility complex--dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease.
European journal of immunology 1989;19(9):1657-67.
1989: D E Speiser; R Schneider; Hans Hengartner; H Robson MacDonald; Rolf M Zinkernagel
Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.
The Journal of experimental medicine 1989;170(2):595-600.
1989: T Leist; Alana Althage; E Haenseler; Hans Hengartner; Rolf M Zinkernagel
Major histocompatibility complex-linked susceptibility or resistance to disease caused by a noncytopathic virus varies with the disease parameter evaluated.
The Journal of experimental medicine 1989;170(1):269-77.
1989: C Müller; D Kägi; T Aebischer; B Odermatt; W Held; Eckhard R Podack; Rolf M Zinkernagel; Hans Hengartner
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
European journal of immunology 1989;19(7):1253-9.
1989: R Schneider; Rosemary K Lees; Thierry Pedrazzini; Rolf M Zinkernagel; Hans Hengartner; H Robson MacDonald
Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.
The Journal of experimental medicine 1989;169(6):2149-58.
1989: E Rüedi; M Sykes; Suzanne Ildstad; C H Chester; Alana Althage; Hans Hengartner; D H Sachs; Rolf M Zinkernagel
Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras.
Cellular immunology 1989;121(1):185-95.
1989: Hanspeter Pircher; Tak W Mak; R Lang; W Ballhausen; E Rüedi; Hans Hengartner; Rolf M Zinkernagel; K Bürki
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.
The EMBO journal 1989;8(3):719-27.
1989: M Hany; Stephan Oehen; M Schulz; Hans Hengartner; M Mackett; D H Bishop; H Overton; Rolf M Zinkernagel
Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein.
European journal of immunology 1989;19(3):417-24.
1989: Rolf M Zinkernagel; Hanspeter Pircher; M Schulz; T Leist; Stephan Oehen; Hans Hengartner
Reactivity and tolerance of virus-specific T cells.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():843-51.
1989: R Schneider; R Lees; Thierry Pedrazzini; B Odermatt; D E Speiser; Rolf M Zinkernagel; Hans Hengartner; H Robson MacDonald
Fate of potentially self-reactive T cells in neonatal mice: analysis of V beta 6+ T cells in Mlsa mice.
Thymus 1989;13(1-2):35-43.
1989: D E Speiser; E Kolb; R Schneider; Hanspeter Pircher; Hans Hengartner; H Robson MacDonald; Rolf M Zinkernagel
Tolerance to Mlsa by clonal deletion of V beta 6+ T cells in bone marrow and thymus chimeras.
Thymus 1989;13(1-2):27-33.
1989: H Robson MacDonald; D Speiser; R Lees; R Schneider; Rolf M Zinkernagel; Hans Hengartner
Positive and negative selection of the T-cell antigen receptor repertoire in nontransgenic mice.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():129-33.
1988: Hans Hengartner; B Odermatt; R Schneider; M Schreyer; G Wälle; H Robson MacDonald; Rolf M Zinkernagel
Deletion of self-reactive T cells before entry into the thymus medulla.
Nature 1988;336(6197):388-90.
1988: J Baenziger; Hans Hengartner; Rolf M Zinkernagel; P Groscurth
Distinct patterns of virus-specific T cell-mediated cytolysis of transformed versus primary target cells.
Scandinavian journal of immunology 1988;28(4):411-23.
1988: H Robson MacDonald; Hans Hengartner; Thierry Pedrazzini
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment.
Nature 1988;335(6186):174-6.
1988: Rolf M Zinkernagel; E Rüedi; Alana Althage; Hans Hengartner; G Reimann
Thymic selection of H-2-incompatible bone marrow cells in SCID mice. Differences in T help for induction of B cell IgG responses versus cytotoxic T cells.
The Journal of experimental medicine 1988;168(3):1187-92.
1988: H Robson MacDonald; Thierry Pedrazzini; R Schneider; Jacques A Louis; Rolf M Zinkernagel; Hans Hengartner
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
The Journal of experimental medicine 1988;167(6):2005-10.
1988: A Cerny; S Sutter; H Bazin; Hans Hengartner; Rolf M Zinkernagel
Clearance of lymphocytic choriomeningitis virus in antibody- and B-cell-deprived mice.
Journal of virology 1988;62(5):1803-7.
1988: H Roost; S Charan; Rita Gobet; E Rüedi; Hans Hengartner; Alana Althage; Rolf M Zinkernagel
An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus.
European journal of immunology 1988;18(4):511-8.
1988: H Robson MacDonald; R Schneider; Rosemary K Lees; R C Howe; Hans Acha-Orbea; H Festenstein; Rolf M Zinkernagel; Hans Hengartner
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
Nature 1988;332(6159):40-5.
1988: L Stitz; Hans Hengartner; Alana Althage; Rolf M Zinkernagel
An easy and rapid method to screen large numbers of antibodies against internal cellular determinants.
Journal of immunological methods 1988;106(2):211-6.
1988: A Cerny; A W Hügin; H Bazin; S Sutter; Hans Hengartner; Rolf M Zinkernagel
Anti-Listeria monocytogenes immunity in mu-suppressed mice: a comparison of treatment with conventional hyperimmune rabbit anti-mouse IgM and affinity-purified, monoclonal rat anti-mouse IgM.
Medical microbiology and immunology 1988;177(3):123-31.
1988: M Schulz; G Lienhard; F Rupp; Rolf M Zinkernagel; Hans Hengartner
Expression of T cell receptor gamma-chain in murine cytotoxic T cells: analysis of a highly transcribed nonrearranged gene cluster.
Experimental cell biology 1988;56(4):181-9.
1988: Rita Gobet; A Cerny; E Rüedi; Hans Hengartner; Rolf M Zinkernagel
The role of antibodies in natural and acquired resistance of mice to vesicular stomatitis virus.
Experimental cell biology 1988;56(4):175-80.
1986: A Cerny; C Heusser; S Sutter; A W Huegin; H Bazin; Hans Hengartner; Rolf M Zinkernagel
Generation of agammaglobulinaemic mice by prenatal and postnatal exposure to polyclonal or monoclonal anti-IgM antibodies.
Scandinavian journal of immunology 1986;24(4):437-45.
1986: Rolf M Zinkernagel; E Haenseler; T Leist; A Cerny; Hans Hengartner; Alana Althage
T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?
The Journal of experimental medicine 1986;164(4):1075-92.
1986: A Cerny; A W Huegin; S Sutter; H Bazin; Hans Hengartner; Rolf M Zinkernagel
Immunity to lymphocytic choriomeningitis virus in B cell-depleted mice: evidence for B cell and antibody-independent protection by memory T cells.
European journal of immunology 1986;16(8):913-7.
1986: A W Hügin; A Cerny; M Wrann; Hans Hengartner; Rolf M Zinkernagel
Effect of cyclosporin A on immunity to Listeria monocytogenes.
Infection and immunity 1986;52(1):12-7.
1986: S Charan; A W Huegin; A Cerny; Hans Hengartner; Rolf M Zinkernagel
Effects of cyclosporin A on humoral immune response and resistance against vesicular stomatitis virus in mice.
Journal of virology 1986;57(3):1139-44.
1985: Rolf M Zinkernagel; T Leist; Hans Hengartner; Alana Althage
Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D.
The Journal of experimental medicine 1985;162(6):2125-41.
1985: A W Huegin; A Cerny; Hans Hengartner; Rolf M Zinkernagel
Suppression by cyclosporin A of murine T-cell-mediated immunity against viruses in vivo and in vitro.
Cellular immunology 1985;90(2):464-73.
1985: A Cerny; A W Hügin; S Sutter; C H Heusser; N Bos; Shozo Izui; Hans Hengartner; Rolf M Zinkernagel
Suppression of B cell development and antibody responses in mice with polyclonal rabbit and monoclonal rat anti-IgM antibodies. I. Characterization of the suppressed state.
Experimental cell biology 1985;53(6):301-13.
1985: Lothar Stitz; Alana Althage; Hans Hengartner; Rolf M Zinkernagel
Natural killer cells vs cytotoxic T cells in the peripheral blood of virus-infected mice.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(1):598-602.